                         SEQUENCE LISTING

<110>  Scribe Therapeutics Inc.
 
<120>  COMPOSITIONS AND METHODS FOR THE TARGETING OF BCL11A

<130>  SCRB-030/01WO 333322-2136

<150>  US 63/120,885
<151>  2020-12-03

<160>  27270 

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Unknown

<220>
<223>  Deltaproteobacteria sp.

<400>  1

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  2
<211>  978
<212>  PRT
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  2

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3
<211>  855
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  3

Met Asp Asn Ala Asn Lys Pro Ser Thr Lys Ser Leu Val Asn Thr Thr 
1               5                   10                  15      


Arg Ile Ser Asp His Phe Gly Val Thr Pro Gly Gln Val Thr Arg Val 
            20                  25                  30          


Phe Ser Phe Gly Ile Ile Pro Thr Lys Arg Gln Tyr Ala Ile Ile Glu 
        35                  40                  45              


Arg Trp Phe Ala Ala Val Glu Ala Ala Arg Glu Arg Leu Tyr Gly Met 
    50                  55                  60                  


Leu Tyr Ala His Phe Gln Glu Asn Pro Pro Ala Tyr Leu Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Tyr Glu Thr Phe Phe Lys Gly Arg Pro Val Leu Asn Gly Leu 
                85                  90                  95      


Arg Asp Ile Asp Pro Thr Ile Met Thr Ser Ala Val Phe Thr Ala Leu 
            100                 105                 110         


Arg His Lys Ala Glu Gly Ala Met Ala Ala Phe His Thr Asn His Arg 
        115                 120                 125             


Arg Leu Phe Glu Glu Ala Arg Lys Lys Met Arg Glu Tyr Ala Glu Cys 
    130                 135                 140                 


Leu Lys Ala Asn Glu Ala Leu Leu Arg Gly Ala Ala Asp Ile Asp Trp 
145                 150                 155                 160 


Asp Lys Ile Val Asn Ala Leu Arg Thr Arg Leu Asn Thr Cys Leu Ala 
                165                 170                 175     


Pro Glu Tyr Asp Ala Val Ile Ala Asp Phe Gly Ala Leu Cys Ala Phe 
            180                 185                 190         


Arg Ala Leu Ile Ala Glu Thr Asn Ala Leu Lys Gly Ala Tyr Asn His 
        195                 200                 205             


Ala Leu Asn Gln Met Leu Pro Ala Leu Val Lys Val Asp Glu Pro Glu 
    210                 215                 220                 


Glu Ala Glu Glu Ser Pro Arg Leu Arg Phe Phe Asn Gly Arg Ile Asn 
225                 230                 235                 240 


Asp Leu Pro Lys Phe Pro Val Ala Glu Arg Glu Thr Pro Pro Asp Thr 
                245                 250                 255     


Glu Thr Ile Ile Arg Gln Leu Glu Asp Met Ala Arg Val Ile Pro Asp 
            260                 265                 270         


Thr Ala Glu Ile Leu Gly Tyr Ile His Arg Ile Arg His Lys Ala Ala 
        275                 280                 285             


Arg Arg Lys Pro Gly Ser Ala Val Pro Leu Pro Gln Arg Val Ala Leu 
    290                 295                 300                 


Tyr Cys Ala Ile Arg Met Glu Arg Asn Pro Glu Glu Asp Pro Ser Thr 
305                 310                 315                 320 


Val Ala Gly His Phe Leu Gly Glu Ile Asp Arg Val Cys Glu Lys Arg 
                325                 330                 335     


Arg Gln Gly Leu Val Arg Thr Pro Phe Asp Ser Gln Ile Arg Ala Arg 
            340                 345                 350         


Tyr Met Asp Ile Ile Ser Phe Arg Ala Thr Leu Ala His Pro Asp Arg 
        355                 360                 365             


Trp Thr Glu Ile Gln Phe Leu Arg Ser Asn Ala Ala Ser Arg Arg Val 
    370                 375                 380                 


Arg Ala Glu Thr Ile Ser Ala Pro Phe Glu Gly Phe Ser Trp Thr Ser 
385                 390                 395                 400 


Asn Arg Thr Asn Pro Ala Pro Gln Tyr Gly Met Ala Leu Ala Lys Asp 
                405                 410                 415     


Ala Asn Ala Pro Ala Asp Ala Pro Glu Leu Cys Ile Cys Leu Ser Pro 
            420                 425                 430         


Ser Ser Ala Ala Phe Ser Val Arg Glu Lys Gly Gly Asp Leu Ile Tyr 
        435                 440                 445             


Met Arg Pro Thr Gly Gly Arg Arg Gly Lys Asp Asn Pro Gly Lys Glu 
    450                 455                 460                 


Ile Thr Trp Val Pro Gly Ser Phe Asp Glu Tyr Pro Ala Ser Gly Val 
465                 470                 475                 480 


Ala Leu Lys Leu Arg Leu Tyr Phe Gly Arg Ser Gln Ala Arg Arg Met 
                485                 490                 495     


Leu Thr Asn Lys Thr Trp Gly Leu Leu Ser Asp Asn Pro Arg Val Phe 
            500                 505                 510         


Ala Ala Asn Ala Glu Leu Val Gly Lys Lys Arg Asn Pro Gln Asp Arg 
        515                 520                 525             


Trp Lys Leu Phe Phe His Met Val Ile Ser Gly Pro Pro Pro Val Glu 
    530                 535                 540                 


Tyr Leu Asp Phe Ser Ser Asp Val Arg Ser Arg Ala Arg Thr Val Ile 
545                 550                 555                 560 


Gly Ile Asn Arg Gly Glu Val Asn Pro Leu Ala Tyr Ala Val Val Ser 
                565                 570                 575     


Val Glu Asp Gly Gln Val Leu Glu Glu Gly Leu Leu Gly Lys Lys Glu 
            580                 585                 590         


Tyr Ile Asp Gln Leu Ile Glu Thr Arg Arg Arg Ile Ser Glu Tyr Gln 
        595                 600                 605             


Ser Arg Glu Gln Thr Pro Pro Arg Asp Leu Arg Gln Arg Val Arg His 
    610                 615                 620                 


Leu Gln Asp Thr Val Leu Gly Ser Ala Arg Ala Lys Ile His Ser Leu 
625                 630                 635                 640 


Ile Ala Phe Trp Lys Gly Ile Leu Ala Ile Glu Arg Leu Asp Asp Gln 
                645                 650                 655     


Phe His Gly Arg Glu Gln Lys Ile Ile Pro Lys Lys Thr Tyr Leu Ala 
            660                 665                 670         


Asn Lys Thr Gly Phe Met Asn Ala Leu Ser Phe Ser Gly Ala Val Arg 
        675                 680                 685             


Val Asp Lys Lys Gly Asn Pro Trp Gly Gly Met Ile Glu Ile Tyr Pro 
    690                 695                 700                 


Gly Gly Ile Ser Arg Thr Cys Thr Gln Cys Gly Thr Val Trp Leu Ala 
705                 710                 715                 720 


Arg Arg Pro Lys Asn Pro Gly His Arg Asp Ala Met Val Val Ile Pro 
                725                 730                 735     


Asp Ile Val Asp Asp Ala Ala Ala Thr Gly Phe Asp Asn Val Asp Cys 
            740                 745                 750         


Asp Ala Gly Thr Val Asp Tyr Gly Glu Leu Phe Thr Leu Ser Arg Glu 
        755                 760                 765             


Trp Val Arg Leu Thr Pro Arg Tyr Ser Arg Val Met Arg Gly Thr Leu 
    770                 775                 780                 


Gly Asp Leu Glu Arg Ala Ile Arg Gln Gly Asp Asp Arg Lys Ser Arg 
785                 790                 795                 800 


Gln Met Leu Glu Leu Ala Leu Glu Pro Gln Pro Gln Trp Gly Gln Phe 
                805                 810                 815     


Phe Cys His Arg Cys Gly Phe Asn Gly Gln Ser Asp Val Leu Ala Ala 
            820                 825                 830         


Thr Asn Leu Ala Arg Arg Ala Ile Ser Leu Ile Arg Arg Leu Pro Asp 
        835                 840                 845             


Thr Asp Thr Pro Pro Thr Pro 
    850                 855 


<210>  4
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  4
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag agaaaccgau aaguaaaacg caucaaag                   108


<210>  5
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  5
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  6
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  6
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  7
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  7
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  8
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  8
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga                                                   80


<210>  9
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  9
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgg                                                      77


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  10
guuuacacac ucccucucau agggu                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  11
guuuacacac ucccucucau gaggu                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  12
uuuuacauac ccccucucau gggau                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  13
guuuacacac ucccucucau ggggg                                             25


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  14
ccagcgacua ugucguaugg                                                   20


<210>  15
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  15
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  16
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  16
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cgga                                                         74


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 spacer target

<400>  17
tgtggtcggg gtagcggctg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E7 spacer target

<400>  18
tcaagtccgc catgcccgaa                                                   20


<210>  19
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  19
ucuccgauaa auaagaagca ucaaag                                            26


<210>  20
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA scaffold stem loop

<400>  20
ccagcgacua ugucguaugg                                                   20


<210>  21
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA extended scaffold stem loop

<400>  21
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  22
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  22
uggagccugu gauaaaagca                                                   20


<210>  23
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  23
ugcuuuuauc acaggcucca                                                   20


<210>  24
<211>  23
<212>  RNA
<213>  Unknown

<220>
<223>  Deltaproteobacteria sp.

<400>  24
ccgauaagua aaacgcauca aag                                               23


<210>  25
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA scaffold stem loop

<400>  25
ccagcgacua ugucguagug g                                                 21


<210>  26
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA stem loop


<220>
<221>  misc_feature
<222>  (4)..(28)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(28)
<223>  individual nucleotides may be absent

<400>  26
uuunnnnnnn nnnnnnnnnn nnnnnnnnuu u                                      31


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MS2 stem loop

<400>  27
acaugaggau uacccaugu                                                    19


<210>  28
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Qbeta stem loop

<400>  28
ugcaugucua agacagca                                                     18


<210>  29
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  H1 hairpin II stem loop

<400>  29
aauccauugc acuccggauu                                                   20


<210>  30
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Uvsx stem loop

<400>  30
ccucuucgga gg                                                           12


<210>  31
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PP7 stem loop

<400>  31
aggaguuucu auggaaaccc u                                                 21


<210>  32
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  phage replication loop

<400>  32
aggugggacg accucucggu cguccuaucu                                        30


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  kissing loop a

<400>  33
ugcucgcucc guucgagca                                                    19


<210>  34
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  kissing loop b1

<400>  34
ugcucgacgc guccucgagc a                                                 21


<210>  35
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  kissing loop b2

<400>  35
ugcucguuug cggcuacgag ca                                                22


<210>  36
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  36

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  37
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  37

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Thr Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser 
            820                 825                 830         


Asp Gly Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu 
    850                 855                 860                 


Leu Ser Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu 
            900                 905                 910         


Asp Cys Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  38
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  38

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys 
        195                 200                 205             


Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn 
                245                 250                 255     


Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu 
            260                 265                 270         


Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro 
305                 310                 315                 320 


Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg Arg 
                325                 330                 335     


Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys Leu 
            340                 345                 350         


Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val Thr 
        355                 360                 365             


Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro Asn 
    370                 375                 380                 


Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys Lys 
385                 390                 395                 400 


Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys Lys 
                405                 410                 415     


Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg Ile 
            420                 425                 430         


Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu Ala 
        435                 440                 445             


Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp Leu 
    450                 455                 460                 


Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp Glu 
465                 470                 475                 480 


Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly Asp 
                485                 490                 495     


Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val Asp 
            500                 505                 510         


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
        515                 520                 525             


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
    530                 535                 540                 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
545                 550                 555                 560 


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
                565                 570                 575     


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
            580                 585                 590         


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
        595                 600                 605             


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
    610                 615                 620                 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
625                 630                 635                 640 


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
                645                 650                 655     


Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp Arg 
            660                 665                 670         


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
        675                 680                 685             


Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile Leu 
    690                 695                 700                 


Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala Ala 
705                 710                 715                 720 


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe Ala 
                725                 730                 735     


Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala Arg 
            740                 745                 750         


Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe Glu 
        755                 760                 765             


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Thr 
    770                 775                 780                 


Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
785                 790                 795                 800 


Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln 
                805                 810                 815     


Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr Ala 
            820                 825                 830         


Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly Trp 
        835                 840                 845             


Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile Thr 
    850                 855                 860                 


Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser Ala 
865                 870                 875                 880 


Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser Lys 
                885                 890                 895     


Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys Arg 
            900                 905                 910         


Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys Gly 
        915                 920                 925             


His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser 
    930                 935                 940                 


Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys Ser 
945                 950                 955                 960 


Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg Arg 
                965                 970                 975     


Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985 


<210>  39
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  39

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
            820                 825                 830         


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
        835                 840                 845             


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
865                 870                 875                 880 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
                885                 890                 895     


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
        915                 920                 925             


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  40
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  40

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala 
        915                 920     


<210>  41
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  41

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala 
        915                 920 


<210>  42
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  42

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Asn Ala Ala 
    50                  55                  60                  


Asn Asn Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala 
65                  70                  75                  80  


Ile Leu Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu 
                85                  90                  95      


Met Cys Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  43
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  43

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  44
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  44

Met Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro Ala Pro 
        35                  40                  45              


Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly Asn Glu 
    50                  55                  60                  


Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu 
65                  70                  75                  80  


Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro His Thr 
                85                  90                  95      


Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu Ile Leu 
            100                 105                 110         


Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser 
        115                 120                 125             


Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile His Val 
    130                 135                 140                 


Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile Gly Gly 
145                 150                 155                 160 


Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp Ala Cys 
                165                 170                 175     


Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu 
            180                 185                 190         


Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu 
        195                 200                 205             


Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu 
    210                 215                 220                 


Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val 
225                 230                 235                 240 


Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln Lys Leu 
                245                 250                 255     


Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe 
            260                 265                 270         


Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp 
        275                 280                 285             


Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp 
    290                 295                 300                 


Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala 
305                 310                 315                 320 


Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys 
                325                 330                 335     


Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys 
            340                 345                 350         


His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile 
        355                 360                 365             


Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu 
    370                 375                 380                 


Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu 
385                 390                 395                 400 


Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys 
                405                 410                 415     


Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp 
            420                 425                 430         


Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Arg Val Val Asp 
        435                 440                 445             


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
    450                 455                 460                 


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
465                 470                 475                 480 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
                485                 490                 495     


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
            500                 505                 510         


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
        515                 520                 525             


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
    530                 535                 540                 


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
545                 550                 555                 560 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
                565                 570                 575     


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
            580                 585                 590         


Val Asp Pro Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg 
        595                 600                 605             


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
    610                 615                 620                 


Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu 
625                 630                 635                 640 


Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys 
                645                 650                 655     


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala 
            660                 665                 670         


Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg 
        675                 680                 685             


Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu 
    690                 695                 700                 


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala 
705                 710                 715                 720 


Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
                725                 730                 735     


Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr 
            740                 745                 750         


Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp 
        755                 760                 765             


Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met 
    770                 775                 780                 


Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr 
785                 790                 795                 800 


Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu 
                805                 810                 815     


Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp 
            820                 825                 830         


Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe 
        835                 840                 845             


Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe 
    850                 855                 860                 


Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp 
865                 870                 875                 880 


Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr 
                885                 890                 895     


Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe 
            900                 905                 910         


Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
        915                 920                 925 


<210>  45
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  45

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Thr Ser Arg Ala Asn 
    50                  55                  60                  


Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu 
65                  70                  75                  80  


His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser 
                85                  90                  95      


Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys 
        195                 200                 205             


Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn 
                245                 250                 255     


Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu 
            260                 265                 270         


Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln 
                325                 330                 335     


Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
785                 790                 795                 800 


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
                805                 810                 815     


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
            820                 825                 830         


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
        835                 840                 845             


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
    850                 855                 860                 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
865                 870                 875                 880 


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
                885                 890                 895     


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
            900                 905                 910         


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
        915                 920                 925             


Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn 
    930                 935                 940                 


Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln 
945                 950                 955                 960 


Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975 


<210>  46
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  46

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Arg Val Val Asp Ile Ser Gly Phe Ser Ile Gly 
            500                 505                 510         


Ser Asp Gly His Ser Ile Gln Tyr Arg Asn Leu Leu Ala Trp Lys Tyr 
        515                 520                 525             


Leu Glu Asn Gly Lys Arg Glu Phe Tyr Leu Leu Met Asn Tyr Gly Lys 
    530                 535                 540                 


Lys Gly Arg Ile Arg Phe Thr Asp Gly Thr Asp Ile Lys Lys Ser Gly 
545                 550                 555                 560 


Lys Trp Gln Gly Leu Leu Tyr Gly Gly Gly Lys Ala Lys Val Ile Asp 
                565                 570                 575     


Leu Thr Phe Asp Pro Asp Asp Glu Gln Leu Ile Ile Leu Pro Leu Ala 
            580                 585                 590         


Phe Gly Thr Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Gly Leu Ile Lys Leu Ala Asn Gly Arg Val Ile Glu Lys 
    610                 615                 620                 


Thr Ile Tyr Asn Lys Lys Ile Gly Arg Asp Glu Pro Ala Leu Phe Val 
625                 630                 635                 640 


Ala Leu Thr Phe Glu Arg Arg Glu Val Val Asp Pro Ser Asn Ile Lys 
                645                 650                 655     


Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val 
            660                 665                 670         


Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp 
        675                 680                 685             


Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys 
    690                 695                 700                 


Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg 
705                 710                 715                 720 


Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala 
                725                 730                 735     


Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val 
            740                 745                 750         


Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly 
        755                 760                 765             


Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met 
    770                 775                 780                 


Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr 
785                 790                 795                 800 


Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn 
                805                 810                 815     


Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys 
            820                 825                 830         


Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu 
        835                 840                 845             


Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln 
    850                 855                 860                 


Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu 
865                 870                 875                 880 


Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu 
                885                 890                 895     


Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu 
            900                 905                 910         


Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln 
        915                 920                 925             


Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu 
    930                 935                 940                 


Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg 
945                 950                 955                 960 


Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu 
                965                 970                 975     


Val Trp Lys Pro Ala Val 
            980         


<210>  47
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  47

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  48
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  48

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala 
    


<210>  49
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  49

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  50
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  50

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  51
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  51

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  52
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  52

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  53
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  53

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  54
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  54

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  55
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  55

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  56
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  56

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  57
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  57

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  58
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  58

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  59
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  59

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  60
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  60

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  61
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  61

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  62
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  62

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  63
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  63

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  64
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  64

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  65
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  65

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  66
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  66

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  67
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  67

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  68
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  68

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  69
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  69

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  70
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  70

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  71
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  71

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  72
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  72

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  73
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  73

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  74
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  74

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  75
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  75

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  76
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  76

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Val 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  77
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  77

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  78
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  78

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  79
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  79

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  80
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  80

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  81
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  81

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  82
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  82

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  83
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  83

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  84
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  84

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  85
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  85

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  86
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  86

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  87
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  87

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  88
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  88

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  89
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  89

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  90
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  90

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  91
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  91

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  92
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  92

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  93
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  93

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  94
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  94

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  95
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  95

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  96
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  96

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  97
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  97

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  98
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  98

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  99
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  99

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  100
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys 
            740                 745                 750         


Asn Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg 
        755                 760                 765             


Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys 
    770                 775                 780                 


Leu Thr Arg His Met Lys Thr His Gly Gln Val Gly Lys Asp Val Tyr 
785                 790                 795                 800 


Lys Cys Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Thr Leu Glu 
                805                 810                 815     


Lys His Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile 
            820                 825                 830         


Lys Thr Glu 
        835 


<210>  101
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  101

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  102
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  102

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  103
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  103

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  104
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  104

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  105
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  105

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  106
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  106

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  107
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  107

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  108
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  108

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  109
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  109

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  110
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  110

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  111
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  111

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  112
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  112

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  113
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  113

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  114
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  114

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  115
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  115

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  116
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  116

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  117
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  117

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  118
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  118

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  119
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  119

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  120
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  120

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  121
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  121

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  122
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  122

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  123
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  123

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  124
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  124

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  125
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  125

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  126
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  126

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  127
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  127

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  128
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  128

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  129
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  129

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  130
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  130

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  131
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  131

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


<210>  132
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  132

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  133
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  133

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  134
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  134

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn His Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  135
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  135

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Ala 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  136
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  136

Arg Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Ala Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala 
225                 230                 235                 240 


Ser Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val 
                245                 250                 255     


Val Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly 
            260                 265                 270         


Lys Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His 
        275                 280                 285             


Thr Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg 
    290                 295                 300                 


Met Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp 
305                 310                 315                 320 


Asp Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu 
                325                 330                 335     


Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn 
            340                 345                 350         


Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp 
        355                 360                 365             


Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu 
    370                 375                 380                 


Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln 
385                 390                 395                 400 


Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp 
                405                 410                 415     


Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu 
            420                 425                 430         


Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp 
        435                 440                 445             


Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser 
    450                 455                 460                 


Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg 
465                 470                 475                 480 


Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro 
                485                 490                 495     


Phe Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser 
            500                 505                 510         


Lys Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys 
        515                 520                 525             


Leu Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg 
    530                 535                 540                 


Phe Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr 
545                 550                 555                 560 


Val Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe 
                565                 570                 575     


Asn Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys 
            580                 585                 590         


Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr 
        595                 600                 605             


Gly Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr 
    610                 615                 620                 


Asn Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr 
625                 630                 635                 640 


Phe Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn 
                645                 650                 655     


Leu Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu 
            660                 665                 670         


Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly 
        675                 680                 685             


Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln 
    690                 695                 700                 


Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly 
705                 710                 715                 720 


Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met 
                725                 730                 735     


Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp 
            740                 745                 750         


Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly 
        755                 760                 765             


Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp 
    770                 775                 780                 


Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  137
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  137

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Gln Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  138
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  138

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Thr Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  139
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  139

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Arg Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  140
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  140

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Tyr Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  141
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  141

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  142
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  142

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Ala Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  143
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  143

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  144
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  144

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  145
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  145

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  146
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  146

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Asn Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  147
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  147

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Trp Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  148
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  148

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Tyr Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  149
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  G quadriplex M3q

<400>  149
agggagggag ggagagg                                                      17


<210>  150
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  G quadriplex telomere basket

<400>  150
gguuaggguu aggguuagg                                                    19


<210>  151
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Sarcin-ricin loop

<400>  151
cugcucagua cgagaggaac cgcag                                             25


<210>  152
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pseudoknots

<400>  152
uacacuggga ucgcugaauu agagaucggc guccuuucau ucuauauacu uuggaguuuu       60

aaaaugucuc uaaguaca                                                     78


<210>  153
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXXC zinc/finger ribbon domain


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  153

Cys Xaa Xaa Cys 
1               


<210>  154
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  154

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Cys Met Gln Val Trp Pro Pro Ile 
    50                  55                  60                  


Gly Lys Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Pro Leu Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Ala 
                


<210>  155
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  155

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Ser 
    50                  55          


<210>  156
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  156

Met Ala Ser Ser Met Leu Ser Ser Ala Thr Met Val Ala Ser Pro Ala 
1               5                   10                  15      


Gln Ala Thr Met Val Ala Pro Phe Asn Gly Leu Lys Ser Ser Ala Ala 
            20                  25                  30          


Phe Pro Ala Thr Arg Lys Ala Asn Asn Asp Ile Thr Ser Ile Thr Ser 
        35                  40                  45              


Asn Gly Gly Arg Val Asn Cys Met Gln Val Trp Pro Pro Ile Glu Lys 
    50                  55                  60                  


Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Asp Leu Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Arg Val Asn Cys 
                85  


<210>  157
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  157

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Gln Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  158
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  158

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Trp Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  159
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  159

Met Ala Gln Ile Asn Asn Met Ala Gln Gly Ile Gln Thr Leu Asn Pro 
1               5                   10                  15      


Asn Ser Asn Phe His Lys Pro Gln Val Pro Lys Ser Ser Ser Phe Leu 
            20                  25                  30          


Val Phe Gly Ser Lys Lys Leu Lys Asn Ser Ala Asn Ser Met Leu Val 
        35                  40                  45              


Leu Lys Lys Asp Ser Ile Phe Met Gln Leu Phe Cys Ser Phe Arg Ile 
    50                  55                  60                  


Ser Ala Ser Val Ala Thr Ala Cys 
65                  70          


<210>  160
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  160

Met Ala Ala Leu Val Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu 
1               5                   10                  15      


Ser Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro 
            20                  25                  30          


Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Val Gly Ala Ser 
        35                  40                  45              


Ala Ala Pro Lys Gln Ser Arg Lys Pro His Arg Phe Asp Arg Arg Cys 
    50                  55                  60                  


Leu Ser Met Val Val 
65                  


<210>  161
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  161

Met Ala Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe 
1               5                   10                  15      


Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe 
            20                  25                  30          


Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu 
        35                  40                  45              


Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val 
    50                  55                  60                  


Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Cys 
65                  70                  75          


<210>  162
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  162

Met Ala Ser Ser Val Leu Ser Ser Ala Ala Val Ala Thr Arg Ser Asn 
1               5                   10                  15      


Val Ala Gln Ala Asn Met Val Ala Pro Phe Thr Gly Leu Lys Ser Ala 
            20                  25                  30          


Ala Ser Phe Pro Val Ser Arg Lys Gln Asn Leu Asp Ile Thr Ser Ile 
        35                  40                  45              


Ala Ser Asn Gly Gly Arg Val Gln Cys 
    50                  55          


<210>  163
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  163

Met Glu Ser Leu Ala Ala Thr Ser Val Phe Ala Pro Ser Arg Val Ala 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Leu Val Arg Ala Gly Thr Val Val Pro Thr 
            20                  25                  30          


Arg Arg Thr Ser Ser Thr Ser Gly Thr Ser Gly Val Lys Cys Ser Ala 
        35                  40                  45              


Ala Val Thr Pro Gln Ala Ser Pro Val Ile Ser Arg Ser Ala Ala Ala 
    50                  55                  60                  


Ala 
65  


<210>  164
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  164

Met Gly Ala Ala Ala Thr Ser Met Gln Ser Leu Lys Phe Ser Asn Arg 
1               5                   10                  15      


Leu Val Pro Pro Ser Arg Arg Leu Ser Pro Val Pro Asn Asn Val Thr 
            20                  25                  30          


Cys Asn Asn Leu Pro Lys Ser Ala Ala Pro Val Arg Thr Val Lys Cys 
        35                  40                  45              


Cys Ala Ser Ser Trp Asn Ser Thr Ile Asn Gly Ala Ala Ala Thr Thr 
    50                  55                  60                  


Asn Gly Ala Ser Ala Ala Ser Ser 
65                  70          


<210>  165
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enbdosomal escape polypeptide


<220>
<221>  SITE
<222>  (4)..(4)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (11)..(11)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (19)..(19)
<223>  Xaa is Lys, His or Arg

<400>  165

Gly Leu Phe Xaa Ala Leu Leu Xaa Leu Leu Xaa Ser Leu Trp Xaa Leu 
1               5                   10                  15      


Leu Leu Xaa Ala 
            20  


<210>  166
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enbdosomal escape polypeptide

<400>  166

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enbdosomal escape polypeptide

<400>  167

His His His His His His His His His 
1               5                   


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  168

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  169
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  169

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  170
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  170

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  171

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  172
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  172

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  173
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  173

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  174

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  175
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  175

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  176
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  176

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  177
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  177

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  178
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  178

Asp Arg Leu Arg Arg 
1               5   


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  179

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  180

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  181

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  182
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  182

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  183
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  183

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  184
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  184

Pro Arg Pro Arg Lys Ile Pro Arg 
1               5               


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  185

Pro Pro Arg Lys Lys Arg Thr Val Val 
1               5                   


<210>  186
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  186

Asn Leu Ser Lys Lys Lys Lys Arg Lys Arg Glu Lys 
1               5                   10          


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  187

Arg Arg Pro Ser Arg Pro Phe Arg Lys Pro 
1               5                   10  


<210>  188
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  188

Lys Arg Pro Arg Ser Pro Ser Ser 
1               5               


<210>  189
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  189

Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly Glu Asn Glu Arg 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  190
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  190

Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn 
1               5                   10      


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  191

Lys Arg Ser Phe Ser Lys Ala Phe 
1               5               


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  192

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  193
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  193

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  194
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  194

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  195
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  195

Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro Thr 
1               5                   10                  15      


<210>  196
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  196

Arg Arg Lys Lys Arg Arg Pro Arg Arg Lys Lys Arg Arg 
1               5                   10              


<210>  197
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  197

Pro Lys Lys Lys Ser Arg Lys Pro Lys Lys Lys Ser Arg Lys 
1               5                   10                  


<210>  198
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  198

His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210>  199
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  199

Gln Arg Pro Gly Pro Tyr Asp Arg Pro Gln Arg Pro Gly Pro Tyr Asp 
1               5                   10                  15      


Arg Pro 
        


<210>  200
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  200

Leu Ser Pro Ser Leu Ser Pro Leu Leu Ser Pro Ser Leu Ser Pro Leu 
1               5                   10                  15      


<210>  201
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  201

Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210>  202
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  202

Pro Lys Arg Gly Arg Gly Arg Pro Lys Arg Gly Arg Gly Arg 
1               5                   10                  


<210>  203
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  203

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  204
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  204

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  205
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  205

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  206
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  206

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  207
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  207

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  208
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  208

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  209
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  209

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  210
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  210

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  211
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  211

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  212
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  212

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  213
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein transduction domain

<400>  213

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  214
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  SITE
<222>  (6)..(10)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (11)..(15)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (16)..(20)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (21)..(25)
<223>  grouped amino acid residues may be present or absent

<400>  214

Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Ser 
            20                  25  


<210>  215
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  SITE
<222>  (7)..(12)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (13)..(18)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (19)..(24)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (25)..(30)
<223>  grouped amino acid residues may be present or absent

<400>  215

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25                  30  


<210>  216
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  SITE
<222>  (5)..(8)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (9)..(12)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (13)..(16)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (17)..(20)
<223>  grouped amino acid residues may be present or absent

<400>  216

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  217
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  217

Gly Gly Ser Gly 
1               


<210>  218
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  218

Gly Gly Ser Gly Gly 
1               5   


<210>  219
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  219

Gly Ser Gly Ser Gly 
1               5   


<210>  220
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  220

Gly Ser Gly Gly Gly 
1               5   


<210>  221
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  221

Gly Gly Gly Ser Gly 
1               5   


<210>  222
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  222

Gly Ser Ser Ser Gly 
1               5   


<210>  223
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  223

Gly Pro Gly Pro 
1               


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  224

Pro Pro Ala Pro Pro Ala 
1               5       


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  225

Pro Pro Pro Gly Pro Pro Pro 
1               5           


<210>  226
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(18)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  individual nucleotides may be absent

<400>  226
uuunnnnnnn nnnnnnnnuu u                                                 21


<210>  227
<211>  3120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40-NLS-CasX-SV40-NLS-TEV cleavage site -TwinStrep tag

<400>  227
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcttccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcagc caaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgccgtcta aaacttacct gagcaagacc ctggctcagt acaccagtaa aacctgtagt     2460

aattgcggct ttaccatcac cagcgccgat tatgaccgcg tgctggaaaa gctgaagaaa     2520

accgccaccg gctggatgac caccatcaat ggtaaagagc ttaaagtcga agggcagatt     2580

acttattaca accgttataa gcggcaaaac gtggtgaaag atctgtcggt tgagctggac     2640

cgtttgtctg aagaaagcgt gaacaatgat atcagctcct ggaccaaagg tcgttccggc     2700

gaagcgttaa gtctgttgaa aaagcgcttt agccatcgcc cggtgcagga aaaattcgtt     2760

tgcctgaact gtggcttcga aacccacgcc gacgagcaag cggcgctcaa tattgcgcgt     2820

agctggctgt tcctgcgcag ccaggaatat aaaaaatatc aaaccaacaa aacaactggc     2880

aataccgaca agcgtgcctt tgttgaaacc tggcagagct tctatcgcaa aaaactgaaa     2940

gaggtctgga aaccggcggt agcgccaaag aaaaaacgca aagtgagcga aaatctttat     3000

tttcaaggta gcgcatggag tcatcctcaa ttcgagaaag gtggaggttc tggcggtgga     3060

tcgggaggtt cagcgtggag ccacccgcag ttcgaaaaag gaaggggatc cggctgctaa     3120


<210>  228
<211>  3123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 119 variant

<400>  228
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcgtccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcaaa gaaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgtctaaaa cttacctgag caagaccctg gctcagtaca ccagtaaaac ctgtagtaat     2460

tgcggcttta ccatcaccag cgccgattat gaccgcgtgc tggaaaagct gaagaaaacc     2520

gccaccggct ggatgaccac catcaatggt aaagagctta aagtcgaagg gcagattact     2580

tattacaacc gttataagcg gcaaaacgtg gtgaaagatc tgtcggttga gctggaccgt     2640

ttgtctgaag aaagcgtgaa caatgatatc agctcctgga ccaaaggtcg ttccggcgaa     2700

gcgttaagtc tgttgaaaaa gcgctttagc catcgcccgg tgcaggaaaa attcgtttgc     2760

ctgaactgtg gcttcgaaac ccacgccgac gagcaagcgg cgctcaatat tgcgcgtagc     2820

tggctgttcc tgcgcagcca ggaatataaa aaatatcaaa ccaacaaaac aactggcaat     2880

accgacaagc gtgcctttgt tgaaacctgg cagagcttct atcgcaagaa gctgaaagag     2940

gtctggaaac cggcggtacc acctgcgcca aagaaaaaac gcaaagtgag cgaaaatctt     3000

tattttcaag gtagcgcatg gagtcatcct caattcgaga aaggtggagg ttctggcggt     3060

ggatcgggag gttcagcgtg gagccacccg cagttcgaaa aaggaagggg atccggctgc     3120

taa                                                                   3123


<210>  229
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 457 variant

<400>  229
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac aagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcc ccgaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaacccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  230
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 438 variant

<400>  230
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgaagc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  231
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 119 variant

<400>  231

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  232
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 457 variant

<400>  232

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Pro 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  233
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 438 variant

<400>  233

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  234
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7 promoter primer

<400>  234
gaaattaata cgactcacta ta                                                22


<210>  235
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg1 backbone fwd

<400>  235
gaaattaata cgactcacta taggtggcgc ttttatctca ttactttgag agccatcacc       60

agcgactatg tcgtatggg                                                    79


<210>  236
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg1 backbone rev

<400>  236
ctttgatgct tcttatttat cggatttctc tccgataaat aagcgcttta cccatacgac       60

atagtcgctg gtgatggc                                                     78


<210>  237
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg1.7.37 spacer primer

<400>  237
cggagcgaga catctcggcc ctttgatgct tcttatttat cggatttctc tccg             54


<210>  238
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2 backbone fwd

<400>  238
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaag                                           87


<210>  239
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2 backbone rev

<400>  239
ctttgatgct tcttatttat cggatttctc tccgataaat aagcgcttta cccatacgac       60

atagtcgctg gtgatggc                                                     78


<210>  240
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2.7.37 spacer primer

<400>  240
cggagcgaga catctcggcc ctttgatgct tcttatttat cggatttctc tccg             54


<210>  241
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32 backbone fwd

<400>  241
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  242
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32 backbone rev

<400>  242
ctttgatgct tccctccgaa gagggcgctt tacccatacg acatag                      46


<210>  243
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32.7.37 spacer primer

<400>  243
cggagcgaga catctcggcc ctttgatgct tccctccgaa gag                         43


<210>  244
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64 backbone fwd

<400>  244
gaaattaata cgactcacta taggtactgg cgcctttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  245
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64 backbone rev

<400>  245
ctttgatgct tcttacggac cgaagtccgt aagcgcttta cccatacgac atag             54


<210>  246
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64.7.37 spacer primer

<400>  246
cggagcgaga catctcggcc ctttgatgct tcttacggac cgaag                       45


<210>  247
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174 backbone fwd

<400>  247
gaaattaata cgactcacta taactggcgc ttttatctga ttactttgag agccatcacc       60

agcgactatg tcgtagtggg taaagct                                           87


<210>  248
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174 backbone rev

<400>  248
ctttgatgct ccctccgaag agggagcttt acccactacg acatagtcgc                  50


<210>  249
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174.7.37 spacer primer

<400>  249
cggagcgaga catctcggcc ctttgatgct ccctcc                                 36


<210>  250
<211>  127
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  250
gguggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaagggc cgagaugucu      120

cgcuccg                                                                127


<210>  251
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  251
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag ggccgagaug      120

ucucgcuccg                                                             130


<210>  252
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  252
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgccc ucuucggagg gaagcaucaa agggccgaga ugucucg                    107


<210>  253
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  253
gguacuggcg ccuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag ggccgagaug ucucgcuccg      120


<210>  254
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  254
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaagg gccgagaugu cucgcuccg                  109


<210>  255
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M target oligo

<400>  255
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  256
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M target oligo

<400>  256
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  257
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV antigenomic ribozyme

<400>  257
gggtcggcat ggcatctcca cctcctcgcg gtccgacctg ggcatccgaa ggaggacgca       60

cgtccactcg gatggctaag ggagagcca                                         89


<210>  258
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV genomic ribozyme

<400>  258
ggccggcatg gtcccagcct cctcgctggc gccggctggg caacattccg aggggaccgt       60

cccctcggta atggcgaatg ggaccc                                            86


<210>  259
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV ribozyme (v1)

<400>  259
gatggccggc atggtcccag cctcctcgct ggcgccggct gggcaacacc ttcgggtggc       60

gaatgggac                                                               69


<210>  260
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV ribozyme (v2)

<400>  260
ttttggccgg catggtccca gcctcctcgc tggcgccggc tgggcaacat gcttcggcat       60

ggcgaatggg accccggg                                                     78


<210>  261
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hatchet

<400>  261
cattcctcag aaaatgacaa acctgtgggg cgtaagtaga tcttcggatc tatgatcgtg       60

cagacgttaa aatcaggt                                                     78


<210>  262
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  env25 pistol ribozyme (with CUUCGG loop)

<400>  262
cgtggttagg gccacgttaa atagttgctt aagccctaag cgttgatctt cggatcaggt       60

gcaa                                                                    64


<210>  263
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HH15 Minimal Hammerhead ribozyme

<400>  263
gggagccccg ctgatgaggt cggggagacc gaaagggact tcggtcccta cggggctccc       60


<210>  264
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sTRSV WT viral Hammerhead ribozyme

<400>  264
cctgtcaccg gatgtgcttt ccggtctgat gagtccgtga ggacgaaaca gg               52


<210>  265
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hammerhead ribozyme

<400>  265
cgactactga tgagtccgtg aggacgaaac gagtaagctc gtctagtcgc gtgtagcgaa       60

gca                                                                     63


<210>  266
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hammerhead ribozyme, smaller scar

<400>  266
cgactactga tgagtccgtg aggacgaaac gagtaagctc gtctagtcg                   49


<210>  267
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hammerhead ribozyme, guide scaffold scar

<400>  267
ccagtactga tgagtccgtg aggacgaaac gagtaagctc gtctactggc gcttttatct       60

cat                                                                     63


<210>  268
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Twisted Sister 1

<400>  268
acccgcaagg ccgacggcat ccgccgccgc tggtgcaagt ccagccgccc cttcgggggc       60

gggcgctcat gggtaac                                                      77


<210>  269
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Env-9 Twister

<400>  269
ggcaataaag cggttacaag cccgcaaaaa tagcagagta atgtcgcgat agcgcggcat       60

taatgcagct ttattg                                                       76


<210>  270
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBMX recruiting motif

<400>  270
ccacccccac caccaccccc acccccacca ccaccc                                 36


<210>  271
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  271
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaagu ggagccugug auaaaagca                  109


<210>  272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  272
uucgggcucu gguugggggu                                                   20


<210>  273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  273
agucucuauu auuuccuugc                                                   20


<210>  274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  274
auauucaugc gcccuuucuc                                                   20


<210>  275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  275
guguuaaagg agaaaagagc                                                   20


<210>  276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  276
gcagugggcu cuuuucuccu                                                   20


<210>  277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  277
cuucaagccc acccccaccu                                                   20


<210>  278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  278
cugcugccac caccaccacu                                                   20


<210>  279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  279
gggacuacac accaccacac                                                   20


<210>  280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  280
uguuggccag gcuggucucg                                                   20


<210>  281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  281
cuugaggcca ggaguucgag                                                   20


<210>  282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  282
acuugcuuug gccucccaaa                                                   20


<210>  283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  283
ccagccgagu gugguggcuc                                                   20


<210>  284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  284
guccaaguau aaggaacccc                                                   20


<210>  285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  285
gacaccaugu aucuguccaa                                                   20


<210>  286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  286
aggucuauca gacaccaugu                                                   20


<210>  287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  287
gaagaaauag agauaaugau                                                   20


<210>  288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  288
cuauuucuuc agaugacaag                                                   20


<210>  289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  289
uuaucucuau uucuucagau                                                   20


<210>  290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  290
ucuuaaguug cuauagguag                                                   20


<210>  291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  291
uguggggaga aguggggaca                                                   20


<210>  292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  292
ugcauaugag aaaauggagg                                                   20


<210>  293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  293
guggcuucaa caccguugag                                                   20


<210>  294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  294
uguuccaugc cagaggaaag                                                   20


<210>  295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  295
uugggcaucu uguuccaugc                                                   20


<210>  296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  296
uaccaucaac acaaucuaaa                                                   20


<210>  297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  297
acacaaucua aacugcagca                                                   20


<210>  298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  298
aaacugcagc aaaaugccaa                                                   20


<210>  299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  299
aguaaacaga gaucuuggac                                                   20


<210>  300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  300
cuguuuacua gauauuuucc                                                   20


<210>  301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  301
uggacuguug agcuaaggau                                                   20


<210>  302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  302
uuagcucaac aguccaagau                                                   20


<210>  303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  303
aagcaaagag gaccucaggg                                                   20


<210>  304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  304
cugagguccu cuuugcuugg                                                   20


<210>  305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  305
cuucuuagga caauugugag                                                   20


<210>  306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  306
uagauagcac agccagagcu                                                   20


<210>  307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  307
aggauaggcu ggaggaaggg                                                   20


<210>  308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  308
augcugugcg uuggguagac                                                   20


<210>  309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  309
uuucccagug cgcauuaaca                                                   20


<210>  310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  310
gaaugucgaa gguacucugg                                                   20


<210>  311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  311
uugaagcccc agaucaauuc                                                   20


<210>  312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  312
ggggcuucaa ggaucagaau                                                   20


<210>  313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  313
auuccuacug cuuccaagaa                                                   20


<210>  314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  314
ucaugaguuc uuggaugaaa                                                   20


<210>  315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  315
aagaacucau gaggaugagc                                                   20


<210>  316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  316
uuauugguuc uccauguucu                                                   20


<210>  317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  317
acaacauaua cucacccaga                                                   20


<210>  318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  318
gggugaguau auguuguaga                                                   20


<210>  319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  319
ugagaacaug ccucuaucuc                                                   20


<210>  320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  320
cuaucuuuau ccauaucccu                                                   20


<210>  321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  321
uuauccauau cccuaccacc                                                   20


<210>  322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  322
auaucccuac caccugguac                                                   20


<210>  323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  323
cuaccaccug guacuccugu                                                   20


<210>  324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  324
gaggacagga guaccaggug                                                   20


<210>  325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  325
caaaggaggg gucaaguuuu                                                   20


<210>  326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  326
uaacuaaacu cugcugcuuu                                                   20


<210>  327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  327
uccuuccaag cccuuuaacu                                                   20


<210>  328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  328
gaaucuccuu ggcacuucag                                                   20


<210>  329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  329
ccuuggcacu ucagucaagg                                                   20


<210>  330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  330
gugcauugug accccuaggu                                                   20


<210>  331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  331
agguuucugg aaggccagaa                                                   20


<210>  332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  332
gcucuaugac aucuucugaa                                                   20


<210>  333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  333
ucugaacucu gcuuuuccca                                                   20


<210>  334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  334
cuuuggcccc uugccaccca                                                   20


<210>  335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  335
cacccccacc ccaucacgua                                                   20


<210>  336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  336
cguaacuguu uaguuaacac                                                   20


<210>  337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  337
uuuuauaucc uuccagauuu                                                   20


<210>  338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  338
uuccagauuu ccuuuacgca                                                   20


<210>  339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  339
ggaaggauau aaaaagauaa                                                   20


<210>  340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  340
auuacaaaaa caaccucaug                                                   20


<210>  341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  341
ucugagcccc gggggcaacg                                                   20


<210>  342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  342
gagccccggg ggcaacgaug                                                   20


<210>  343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  343
uugcccccgg ggcucagaug                                                   20


<210>  344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  344
gugguaugcc aggccuccca                                                   20


<210>  345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  345
ccucagccuu ucaacuuggu                                                   20


<210>  346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  346
ugggcuagga aucaggagac                                                   20


<210>  347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  347
ggagacuugg auuuccugca                                                   20


<210>  348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  348
aagucuccug auuccuagcc                                                   20


<210>  349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  349
ucuccaagcc ucguucuucu                                                   20


<210>  350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  350
uuagaaugag gagauggccc                                                   20


<210>  351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  351
ccucauucua aagaugagaa                                                   20


<210>  352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  352
ccugggccau cuccucauuc                                                   20


<210>  353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  353
uccagggauc ugcccacacc                                                   20


<210>  354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  354
cuggaagauc accugggcca                                                   20


<210>  355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  355
gcccacacca gcacggcccu                                                   20


<210>  356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  356
ccauagcaca caaugucugc                                                   20


<210>  357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  357
acacgcuaau gggcacaggu                                                   20


<210>  358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  358
cagcuaaaau ggcacagccu                                                   20


<210>  359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  359
uggggcaaca auucuuuccc                                                   20


<210>  360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  360
aggagaccuc acuuaggcuu                                                   20


<210>  361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  361
ucaaggagac cucacuuagg                                                   20


<210>  362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  362
agauauggau cccaugacac                                                   20


<210>  363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  363
ggaucaucaa ggagaccuca                                                   20


<210>  364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  364
auaucuggau caucaaggag                                                   20


<210>  365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  365
caugacaccu aaggacacau                                                   20


<210>  366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  366
agggaggcua gacuacccac                                                   20


<210>  367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  367
guggguaguc uagccucccu                                                   20


<210>  368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  368
uugaagcagg uggcaccaga                                                   20


<210>  369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  369
cuccuguuuc uaacagcagg                                                   20


<210>  370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  370
gguccacccu cuuugucuac                                                   20


<210>  371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  371
guagacaaag aggguggacc                                                   20


<210>  372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  372
cuucccugcc uguccugcuu                                                   20


<210>  373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  373
cuaauaggga acggggcucc                                                   20


<210>  374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  374
cuaucccuaa uagggaacgg                                                   20


<210>  375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  375
gagcuugugg aauuuacuuc                                                   20


<210>  376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  376
cucaauagaa guaaauucca                                                   20


<210>  377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  377
ccacuucucu cugccugucu                                                   20


<210>  378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  378
ucucuucuuu gaaaagcagc                                                   20


<210>  379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  379
ucugaacagc uugcagcauu                                                   20


<210>  380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  380
aggaacuggg cacccgucau                                                   20


<210>  381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  381
aagcggcagc ccagaacuca                                                   20


<210>  382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  382
ugcuccucuu gaagacgccc                                                   20


<210>  383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  383
gucaacaggc aaguaaguug                                                   20


<210>  384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  384
cucauguccc caugccagca                                                   20


<210>  385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  385
ggcuugaggg ucguuucggu                                                   20


<210>  386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  386
ucccucccau cauuacagca                                                   20


<210>  387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  387
uuacagcaac acacacacac                                                   20


<210>  388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  388
auagaggagg aguugagugg                                                   20


<210>  389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  389
cagggcccuu ucggacugga                                                   20


<210>  390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  390
cacauccuag ucuacacgca                                                   20


<210>  391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  391
uagucuacac gcaucaccug                                                   20


<210>  392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  392
ccugccaccc aacucguccc                                                   20


<210>  393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  393
uucuaaaugu gggcaggggc                                                   20


<210>  394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  394
uauaauuucc agaccguccu                                                   20


<210>  395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  395
gagagaaacc uuaauguuug                                                   20


<210>  396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  396
aacauuaagg uuucucucgg                                                   20


<210>  397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  397
caacgaggaa gaaaucaaac                                                   20


<210>  398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  398
ugagcuccac aagccacaaa                                                   20


<210>  399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  399
uugaggccaa aaugguguuu                                                   20


<210>  400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  400
auuuuuuaug augcagaauu                                                   20


<210>  401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  401
uaaaaaaugg auuuacaagc                                                   20


<210>  402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  402
cguugcacau gcuguacaau                                                   20


<210>  403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  403
gcaucgcguu gcacaugcug                                                   20


<210>  404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  404
ccgugagaaa cuuaacuuuu                                                   20


<210>  405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  405
uuguuuuggg agguacacau                                                   20


<210>  406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  406
gguaggggga aauucuauau                                                   20


<210>  407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  407
cacugaacaa auuaaaaaug                                                   20


<210>  408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  408
aguucugggu uucuuacuga                                                   20


<210>  409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  409
uucucuuccu ccucccuccu                                                   20


<210>  410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  410
cugaccugaa gugagacauu                                                   20


<210>  411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  411
cagcccagag aaggugagca                                                   20


<210>  412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  412
aagugauuug ggcaaauaua                                                   20


<210>  413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  413
cuuggauaag uuuuucuccu                                                   20


<210>  414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  414
gauuaucaca agcccuauuc                                                   20


<210>  415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  415
gauauauuug cccaaaucac                                                   20


<210>  416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  416
caagcccuau ucucuuucug                                                   20


<210>  417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  417
gugccaacag aaagagaaua                                                   20


<210>  418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  418
ggaaauguaa uucaccaccc                                                   20


<210>  419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  419
uugaccugga acagguuuga                                                   20


<210>  420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  420
guugcuaaac ugugcucuau                                                   20


<210>  421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  421
auuagcuuua uaaaugaagc                                                   20


<210>  422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  422
auuaacaaau aaagcuaauc                                                   20


<210>  423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  423
accugucaca ugacuaaauu                                                   20


<210>  424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  424
agagaagagu agaauaagag                                                   20


<210>  425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  425
ugacugaagc aaagagugug                                                   20


<210>  426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  426
cacagacuca cugucucauu                                                   20


<210>  427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  427
uggggaaggg ccaagaagaa                                                   20


<210>  428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  428
uuccauccuu ccaagccuca                                                   20


<210>  429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  429
uuccaagccu cauucagccc                                                   20


<210>  430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  430
gggggagcuu cagagaggaa                                                   20


<210>  431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  431
ccuggcgacu uguaccagcu                                                   20


<210>  432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  432
caugugucug ugcauuccaa                                                   20


<210>  433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  433
aaauuuuaaa ugcacuuggc                                                   20


<210>  434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  434
agccuaugga aacacuagcc                                                   20


<210>  435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  435
uuauauaagu gggcuagugu                                                   20


<210>  436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  436
ugaauaaugu gcuuacugug                                                   20


<210>  437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  437
ggagcaaacc caaauggcca                                                   20


<210>  438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  438
uuuuugaaaa ugaugcuaca                                                   20


<210>  439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  439
uuuucaaaaa cgauacucuu                                                   20


<210>  440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  440
guauaauugu agguacauuu                                                   20


<210>  441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  441
aaaaagcaaa ccacagaaca                                                   20


<210>  442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  442
uacuauaagu guuguucugu                                                   20


<210>  443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  443
uuuuaagaac uagguaguaa                                                   20


<210>  444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  444
gugcucuuag uuaugacuuu                                                   20


<210>  445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  445
aaguguuuug aguccuaaau                                                   20


<210>  446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  446
auauccaagu guuuugaguc                                                   20


<210>  447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  447
uggcuucacu gccuacuacc                                                   20


<210>  448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  448
caguuuccuu aucucucaaa                                                   20


<210>  449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  449
cucaaauggg gaaaacaguc                                                   20


<210>  450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  450
ggacaugcca gacacaauuc                                                   20


<210>  451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  451
gaaaaggaaa aaagacugaa                                                   20


<210>  452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  452
uuucagucuu uuuuccuuuu                                                   20


<210>  453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  453
uauaaaaaua ccuccuauuu                                                   20


<210>  454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  454
aaccugccau gcuacugaca                                                   20


<210>  455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  455
cagguagcag uuuguccuua                                                   20


<210>  456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  456
ugacgucuua cauuacaucu                                                   20


<210>  457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  457
ugauucuaau uccaauccac                                                   20


<210>  458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  458
ggauuuagaa auggggaagc                                                   20


<210>  459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  459
acagccagaa aauuaaaaaa                                                   20


<210>  460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  460
uuuauuuuuu aauuuucugg                                                   20


<210>  461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  461
ccagcugcug ccccacgcau                                                   20


<210>  462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  462
guuuuaaaaa augaaagcau                                                   20


<210>  463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  463
auuacuauuu uaaacgggaa                                                   20


<210>  464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  464
ugacagccaa gguagggucu                                                   20


<210>  465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  465
ucuuccugua guagaagaug                                                   20


<210>  466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  466
uccuguagua gaagaugguu                                                   20


<210>  467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  467
ucuacuacag gaagaugauu                                                   20


<210>  468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  468
ucgucuucca agacaccuuc                                                   20


<210>  469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  469
cucugaguug ggaguaggga                                                   20


<210>  470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  470
ggguggcucu ccuucuggug                                                   20


<210>  471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  471
ugacaugagu caccagaagg                                                   20


<210>  472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  472
caugacaauc ccgucccacu                                                   20


<210>  473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  473
cgucccacug gcuacaacaa                                                   20


<210>  474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  474
aaaguccuug gcccgacacu                                                   20


<210>  475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  475
ccagaaagag agaggaccug                                                   20


<210>  476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  476
caaaaaggaa aaaaaaaaaa                                                   20


<210>  477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  477
cggcucacug caacucucac                                                   20


<210>  478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  478
ugggagguga gaguugcagu                                                   20


<210>  479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  479
agugauucuc cugccucagc                                                   20


<210>  480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  480
cuugauccug ggaggugaga                                                   20


<210>  481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  481
cgucucuacu aaaaaaauac                                                   20


<210>  482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  482
uggccaacau ggugaaaucc                                                   20


<210>  483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  483
uccuggccaa cauggugaaa                                                   20


<210>  484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  484
caaucucuug accuugugau                                                   20


<210>  485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  485
cuugaccuug ugauccaccc                                                   20


<210>  486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  486
caaggucaag agauugagau                                                   20


<210>  487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  487
acccgccuca gccucccaaa                                                   20


<210>  488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  488
caguacuuug ggaggcugag                                                   20


<210>  489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  489
cuaugcuguu aucagcuugc                                                   20


<210>  490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  490
gcuugcuuuu cacauaccca                                                   20


<210>  491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  491
uuauguauug gcuggggacc                                                   20


<210>  492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  492
auuuccccca cuccccucug                                                   20


<210>  493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  493
ugugccuagc agaaaaccca                                                   20


<210>  494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  494
cacaagccac ccucugaaug                                                   20


<210>  495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  495
aguugaagag acaagcucua                                                   20


<210>  496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  496
caaauuccug gaaggcagga                                                   20


<210>  497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  497
ugccuuccag gaauuugcga                                                   20


<210>  498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  498
gagaaaggaa aagaagcaag                                                   20


<210>  499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  499
ugccccaaaa guuuaaugug                                                   20


<210>  500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  500
aucugacagc ucgcuaacuu                                                   20


<210>  501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  501
gacagcucgc uaacuuugua                                                   20


<210>  502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  502
uuuuuuuuuu cuuucccagc                                                   20


<210>  503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  503
aaaacuuuca gcucugauaa                                                   20


<210>  504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  504
gagcugaaag uuuuggauuu                                                   20


<210>  505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  505
uaucagagcu gaaaguuuug                                                   20


<210>  506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  506
aaaauuagag agaagugacc                                                   20


<210>  507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  507
uggucacuuc ucucuaauuu                                                   20


<210>  508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  508
acuauaaagc cagucaacua                                                   20


<210>  509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  509
ugcaucuacu auaaagccag                                                   20


<210>  510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  510
auuuaaauga cuuucuuagg                                                   20


<210>  511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  511
gaugccagaa guccauuuaa                                                   20


<210>  512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  512
gauacauugc cugcugcucc                                                   20


<210>  513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  513
ugaaucuauu ugaaagauaa                                                   20


<210>  514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  514
auuugaaaga uaaacacauu                                                   20


<210>  515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  515
uucaaauaga uucaagauga                                                   20


<210>  516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  516
guauuuguac aaauccaggc                                                   20


<210>  517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  517
aggccgagcu ggccaacugg                                                   20


<210>  518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  518
ccaauuucaa uaggacuuug                                                   20


<210>  519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  519
guaagacagc aguagguguc                                                   20


<210>  520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  520
cagcguuagg cccaucugua                                                   20


<210>  521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  521
uacuggaaaa gcaauuuaaa                                                   20


<210>  522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  522
caggaaaagg uucaguuuug                                                   20


<210>  523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  523
uggccuugug cagguggugg                                                   20


<210>  524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  524
cuaaccucug cauuccugca                                                   20


<210>  525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  525
agaguccaua aggggucacu                                                   20


<210>  526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  526
gacauaacau cucacaagau                                                   20


<210>  527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  527
cacaagauga gguguggcac                                                   20


<210>  528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  528
ugugagaugu uaugucugau                                                   20


<210>  529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  529
caacugugcu ggaaacuggg                                                   20


<210>  530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  530
ucaccagcca gccccaguuu                                                   20


<210>  531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  531
uagcugaagc cucaguggaa                                                   20


<210>  532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  532
aauuucccau aaaaugggac                                                   20


<210>  533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  533
gaauggcuuu cuuuuuaggg                                                   20


<210>  534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  534
cauauaauuc uuugaaaacg                                                   20


<210>  535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  535
auauggcuug cuagugcccc                                                   20


<210>  536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  536
auaugaauug uugucuugga                                                   20


<210>  537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  537
cuuccucccc aucaauauga                                                   20


<210>  538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  538
cugcccucau uaaaaaagca                                                   20


<210>  539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  539
caguugucac cuuuauguuu                                                   20


<210>  540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  540
ccugguugag acaacucgcu                                                   20


<210>  541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  541
cuugccauua gcacaugaaa                                                   20


<210>  542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  542
aaugccuuua guagggauga                                                   20


<210>  543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  543
cuacuaaagg cauuagauau                                                   20


<210>  544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  544
auaaugucaa cuucagucau                                                   20


<210>  545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  545
uacuacaucu auaaugucaa                                                   20


<210>  546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  546
augccccaag gauguuaaga                                                   20


<210>  547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  547
uuggggcaug gaucuuacua                                                   20


<210>  548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  548
uaacauccuu ggggcaugga                                                   20


<210>  549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  549
guguuagcuc ugauaagaaa                                                   20


<210>  550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  550
gagcuaacac agauuauuug                                                   20


<210>  551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  551
uggaaggaga agugaaaaga                                                   20


<210>  552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  552
aaguagggga agacagaaaa                                                   20


<210>  553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  553
aacuguguuc auuuggcaaa                                                   20


<210>  554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  554
gaacuuggcu uaggaacagg                                                   20


<210>  555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  555
aggaguugca cuuaugugca                                                   20


<210>  556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  556
cuuaauacau cuaaauucug                                                   20


<210>  557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  557
aaauucugau gaagucaaug                                                   20


<210>  558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  558
gaauuuagau guauuaaggg                                                   20


<210>  559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  559
ucaagggacu accaccaacu                                                   20


<210>  560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  560
ccaugugaac uggaaaagcu                                                   20


<210>  561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  561
aagagaagua caaaaaggca                                                   20


<210>  562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  562
uucauuuugg uuucuacuuu                                                   20


<210>  563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  563
aauuuuuaac uuucuaaggu                                                   20


<210>  564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  564
gccucuucca cccaauaugg                                                   20


<210>  565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  565
ucugaaguuu cuggcuuaua                                                   20


<210>  566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  566
uuacuguuuu guuucaagaa                                                   20


<210>  567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  567
guugacaaua cuuuuugcua                                                   20


<210>  568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  568
uuuucucuau uucaugccaa                                                   20


<210>  569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  569
ucuaguccug acuaauugaa                                                   20


<210>  570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  570
ccaccuauuu uaaaguguaa                                                   20


<210>  571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  571
uccucccacu cuuguucuua                                                   20


<210>  572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  572
acgcacauga guguaguggg                                                   20


<210>  573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  573
ugauguuacu uuaaagccau                                                   20


<210>  574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  574
agauuaagga aaguuuuuca                                                   20


<210>  575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  575
uaaaucaugc aaccugccaa                                                   20


<210>  576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  576
ugcaaccugc caaucuuguu                                                   20


<210>  577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  577
uguuguguuu uauaaacugu                                                   20


<210>  578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  578
uugggccaga aaugcucuac                                                   20


<210>  579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  579
ccuaguaaca aaugccaguu                                                   20


<210>  580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  580
cuucccauug uaaaaaaaga                                                   20


<210>  581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  581
ggcuagucau aagagaauau                                                   20


<210>  582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  582
ggcaggaaag gccuacguac                                                   20


<210>  583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  583
aggagcaugg gcaggcuggg                                                   20


<210>  584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  584
aaaucagugc caaaaccaag                                                   20


<210>  585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  585
gugccaaaac caagcccuga                                                   20


<210>  586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  586
ugaaggccau gcagaguguc                                                   20


<210>  587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  587
auggaaaagg cagaacccag                                                   20


<210>  588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  588
aacaaagucu ccggcagccc                                                   20


<210>  589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  589
ugccuacauu ucccugagug                                                   20


<210>  590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  590
cucucccucu cauguagagg                                                   20


<210>  591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  591
gugucuaauu cauucauccc                                                   20


<210>  592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  592
uccgugucua auucauucau                                                   20


<210>  593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  593
ggccuuuaau auggagccuu                                                   20


<210>  594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  594
cagcacaaac ugaccaggac                                                   20


<210>  595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  595
ccugcuuccc ccucccuucu                                                   20


<210>  596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  596
acgcaagcag ccuguuguuu                                                   20


<210>  597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  597
augcuuuuua cacuauugau                                                   20


<210>  598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  598
auaguguaaa aagcauugau                                                   20


<210>  599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  599
gcuauguaua uuuuaugaga                                                   20


<210>  600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  600
uuuucgccuu caguaacaaa                                                   20


<210>  601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  601
uuguuacuga aggcgaaaau                                                   20


<210>  602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  602
gggaguuuuu ugaucccugg                                                   20


<210>  603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  603
aaaaacuccc ugauuuuauc                                                   20


<210>  604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  604
cuggcacagu cucgccagcc                                                   20


<210>  605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  605
auccuccauc cccucuuccu                                                   20


<210>  606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  606
cucuccaucc auccuccauc                                                   20


<210>  607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  607
auguccuucc cuuuggugcc                                                   20


<210>  608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  608
cccgcuaggu aguuaaccug                                                   20


<210>  609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  609
ggaauaauua aaccacaaua                                                   20


<210>  610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  610
uaagggccaa ccugauccuu                                                   20


<210>  611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  611
gguuggcccu uaggaugugg                                                   20


<210>  612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  612
uucuccaaca auucaagucg                                                   20


<210>  613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  613
gccucucugc ucauggcgau                                                   20


<210>  614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  614
ccaugagcag agaggcagau                                                   20


<210>  615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  615
uccagaaugu uugccuagaa                                                   20


<210>  616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  616
aacuucagaa uuaacaauuc                                                   20


<210>  617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  617
gggaaagcuu ccugguggag                                                   20


<210>  618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  618
auuagggaag gcacaugagg                                                   20


<210>  619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  619
aagcagaauu gaacugaaug                                                   20


<210>  620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  620
agauuucacu gccgcuuucu                                                   20


<210>  621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  621
ugauggcugc agggucauaa                                                   20


<210>  622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  622
ggccucuguu cuaauuaaag                                                   20


<210>  623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  623
ugaggacagc ugucccuuuu                                                   20


<210>  624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  624
ccaaagcccu uuccugacaa                                                   20


<210>  625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  625
guccagcaca auguuucaca                                                   20


<210>  626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  626
ugggacagug ugaaacauug                                                   20


<210>  627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  627
uugaucacug caagggcaug                                                   20


<210>  628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  628
aagaugcaaa ugccuugggu                                                   20


<210>  629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  629
cugcaagggc augaaacacu                                                   20


<210>  630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  630
ccuuucugaa gccuaccauc                                                   20


<210>  631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  631
acuaaguaau gaaaucuaau                                                   20


<210>  632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  632
aauauuuaaa gggcaugaca                                                   20


<210>  633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  633
aguauaaacg ggugucaugc                                                   20


<210>  634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  634
auguuucaug gaagggauaa                                                   20


<210>  635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  635
cuuccaugaa acauugauua                                                   20


<210>  636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  636
uuuaugcaug ccuuuuuccu                                                   20


<210>  637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  637
ggaaaaaggc augcauaaag                                                   20


<210>  638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  638
gcacugcauu uuuuaaaugg                                                   20


<210>  639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  639
agugccucca aaauauuaag                                                   20


<210>  640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  640
uauuuaccug aacuucaccu                                                   20


<210>  641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  641
cagauaucuu uccuggagga                                                   20


<210>  642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  642
gugauauccu auuuaccuga                                                   20


<210>  643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  643
uuccuggagg auguugacca                                                   20


<210>  644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  644
ugguuccuga augacacuuu                                                   20


<210>  645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  645
aaaugauuac aguagguaaa                                                   20


<210>  646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  646
uuuugauugc uuucaguuuc                                                   20


<210>  647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  647
uaauuuacuu aaccauuuac                                                   20


<210>  648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  648
aguuguaacc acagugucau                                                   20


<210>  649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  649
cucacacggu uauuauuuuu                                                   20


<210>  650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  650
ugagugauau uaucccuuau                                                   20


<210>  651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  651
cucaugaucc cucacacggu                                                   20


<210>  652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  652
cuuaucuuua cuucucgaaa                                                   20


<210>  653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  653
uuacuucucg aaauauccau                                                   20


<210>  654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  654
auaaugcucu gucuuuauga                                                   20


<210>  655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  655
uaaagacaga gcauuaugga                                                   20


<210>  656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  656
uaauuugggu uuacuauagu                                                   20


<210>  657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  657
agaaagaggc cuauaacucu                                                   20


<210>  658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  658
cuggauggga gaaagcagca                                                   20


<210>  659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  659
agugauacug aaauaaacug                                                   20


<210>  660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  660
cucucccugu ggccauucca                                                   20


<210>  661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  661
uggcucugcu acagaagauc                                                   20


<210>  662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  662
caggucaaag cugcaaguug                                                   20


<210>  663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  663
gcuguguaug aucuuugaag                                                   20


<210>  664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  664
uacacagcgg aucucagguc                                                   20


<210>  665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  665
uugaagaguu aagaagaaug                                                   20


<210>  666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  666
acuggaacaa ugggagguaa                                                   20


<210>  667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  667
ugcauacuuc uuggccagaa                                                   20


<210>  668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  668
auucccaaau gagcaccucu                                                   20


<210>  669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  669
aaaguguuau gguaaaaagc                                                   20


<210>  670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  670
acccuggugu auuaaaauau                                                   20


<210>  671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  671
aacacugguc ugugagucua                                                   20


<210>  672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  672
uauucagcuu ggaagccaga                                                   20


<210>  673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  673
uuuaacacac cauaggagug                                                   20


<210>  674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  674
caguguuuuu ggucucacuu                                                   20


<210>  675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  675
uuucccuggg aagaacaugg                                                   20


<210>  676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  676
aguccuaccc uucgcuacag                                                   20


<210>  677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  677
uuccaacuua augccuccuu                                                   20


<210>  678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  678
ucugaggguc aacgcaguug                                                   20


<210>  679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  679
ucacaacaaa ucagaaaaac                                                   20


<210>  680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  680
aaugagauca uaggauguuc                                                   20


<210>  681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  681
cauuugaucc ucacaacaaa                                                   20


<210>  682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  682
uaggauguuc uuugaaaauu                                                   20


<210>  683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  683
uaugaucuca uuugauccuc                                                   20


<210>  684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  684
uagcucauau uuucuaggaa                                                   20


<210>  685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  685
aaacacauga ugcugaaggc                                                   20


<210>  686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  686
uguguuuaga uggcugggcg                                                   20


<210>  687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  687
ugcguggaau gcgcuuguga                                                   20


<210>  688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  688
auuuucugcc uguaguugca                                                   20


<210>  689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  689
ggaauaaaaa gcaaaggucu                                                   20


<210>  690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  690
guuuauagaa aaaccagagc                                                   20


<210>  691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  691
gcaaaaugag gccuucugug                                                   20


<210>  692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  692
cuaccucucc uucucuccug                                                   20


<210>  693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  693
agguacauuu gcccccguac                                                   20


<210>  694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  694
aucauguuag ggaaagacua                                                   20


<210>  695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  695
uguuagggaa agacuaaauu                                                   20


<210>  696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  696
agaaaacuaa uguaauauuu                                                   20


<210>  697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  697
guguuuuaau aacuguauaa                                                   20


<210>  698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  698
uuugugcuua ggguuuuuug                                                   20


<210>  699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  699
acccauggua acgugcacuu                                                   20


<210>  700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  700
uccuggaggu caaaugcuaa                                                   20


<210>  701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  701
auuuaaagca aauauauggu                                                   20


<210>  702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  702
guaauuuaag gugucaaggu                                                   20


<210>  703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  703
caguguuaga ggaaguguuu                                                   20


<210>  704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  704
guaccccuug ccacggugaa                                                   20


<210>  705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  705
ucacuucccc accucucauc                                                   20


<210>  706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  706
guucacuuaa caaguuuccu                                                   20


<210>  707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  707
ucuuaucugu ucacuuaaca                                                   20


<210>  708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  708
aggagcugug ucaacacugg                                                   20


<210>  709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  709
gaauggcaag gcuaauacca                                                   20


<210>  710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  710
ugggcaacgc cagccucaga                                                   20


<210>  711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  711
ccaauaagac aauaagaaau                                                   20


<210>  712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  712
ggcacaaacc ucccaaggug                                                   20


<210>  713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  713
auucuagaau augagagauu                                                   20


<210>  714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  714
cucauauucu agaauggaug                                                   20


<210>  715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  715
ugugaagggc uucauuauag                                                   20


<210>  716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  716
uuacaauuac cccaguuuac                                                   20


<210>  717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  717
augaaaacac uggaccucca                                                   20


<210>  718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  718
gugauggaac acagaaugga                                                   20


<210>  719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  719
cugauuaauu uugugacuca                                                   20


<210>  720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  720
aacacguagc acagauccuu                                                   20


<210>  721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  721
gugcuacgug uuggauuagg                                                   20


<210>  722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  722
uuacaguuca gccaagcaga                                                   20


<210>  723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  723
ugggcaaggg uuugaaccug                                                   20


<210>  724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  724
uuaaucauuu ccaaaacauu                                                   20


<210>  725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  725
uuuccaaaac auuccaaaug                                                   20


<210>  726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  726
ucucauuuag uucuucuaac                                                   20


<210>  727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  727
cauuuaguuc uucuaacagc                                                   20


<210>  728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  728
ugaaccagaa aacaguugaa                                                   20


<210>  729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  729
agcgguugaa ggucaaguuc                                                   20


<210>  730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  730
agaccuagac caucaaacca                                                   20


<210>  731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  731
aaccagaaac ugcucauccc                                                   20


<210>  732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  732
uguuugguua aauaauaaaa                                                   20


<210>  733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  733
guuccaugca cauucccacu                                                   20


<210>  734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  734
gacaugguga aucacaaaaa                                                   20


<210>  735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  735
caaaaagaca uuguuuucca                                                   20


<210>  736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  736
guuugccuga uuccuggccc                                                   20


<210>  737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  737
ggcaaacaga uaaaaacgug                                                   20


<210>  738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  738
uagggucucu cagaguuuua                                                   20


<210>  739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  739
aaguauuaug ugaucaaaac                                                   20


<210>  740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  740
cauaauacuu ggauugcaca                                                   20


<210>  741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  741
aaacacugaa cugcccuaau                                                   20


<210>  742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  742
aacaaaaaca cuguauuagg                                                   20


<210>  743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  743
uuuggggguc agugguguuu                                                   20


<210>  744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  744
cgaaaaaaaa aaaaagaaaa                                                   20


<210>  745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  745
gugucagagc caugauucag                                                   20


<210>  746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  746
uggcucugac acugauaagc                                                   20


<210>  747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  747
gauucaggac ucugcuccua                                                   20


<210>  748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  748
gaugcccgua ccugaaucau                                                   20


<210>  749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  749
cuugagguca ggaguuugag                                                   20


<210>  750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  750
uccagccuca gccccucaaa                                                   20


<210>  751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  751
ccauaucuua ucacuacagu                                                   20


<210>  752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  752
uaucacuaca guuuuauucu                                                   20


<210>  753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  753
cuacaguuuu auucuuuugg                                                   20


<210>  754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  754
uggaagggca augucuagaa                                                   20


<210>  755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  755
guaaauaucu uaguucucaa                                                   20


<210>  756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  756
uaguucucaa guaacgaauu                                                   20


<210>  757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  757
guggggcugu cuuucugcaa                                                   20


<210>  758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  758
acuagacucu agccuagacu                                                   20


<210>  759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  759
auuccuuuaa ccaaagccug                                                   20


<210>  760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  760
auuuagcaag uauucugggg                                                   20


<210>  761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  761
cccaaauuag uagccagcug                                                   20


<210>  762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  762
aaccugaggg uauuugugug                                                   20


<210>  763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  763
uucuagugaa uuaucaaacc                                                   20


<210>  764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  764
agagcucugg ggauccaauc                                                   20


<210>  765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  765
ccagagcucu ugaugugagc                                                   20


<210>  766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  766
aauccacucc agagcaucug                                                   20


<210>  767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  767
acuccagagc aucuggggaa                                                   20


<210>  768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  768
ggggaaaagc caccugcucc                                                   20


<210>  769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  769
cagcguguag gucuugggaa                                                   20


<210>  770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  770
agagguuugg aaauugagcc                                                   20


<210>  771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  771
cuuagaacug ggggaagcca                                                   20


<210>  772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  772
ggagugguca gaacguggag                                                   20


<210>  773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  773
cugugucuga aggggguaag                                                   20


<210>  774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  774
gcuucuucuu aguggugugu                                                   20


<210>  775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  775
cucaggacaa ucugcuucuu                                                   20


<210>  776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  776
gagacucaca cauacuuccc                                                   20


<210>  777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  777
gaucccaaaa auccaucuag                                                   20


<210>  778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  778
gauguggcug cauaaagacg                                                   20


<210>  779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  779
caaaaaucca ucuagacuca                                                   20


<210>  780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  780
aucuagacuc acuggaagaa                                                   20


<210>  781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  781
agacucacug gaagaaagca                                                   20


<210>  782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  782
guaugaaaug uaggugcaug                                                   20


<210>  783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  783
cugugaugga aagcaguggc                                                   20


<210>  784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  784
cagugaugaa uuuacauggg                                                   20


<210>  785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  785
uauguaugca aguuuuaauu                                                   20


<210>  786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  786
auugggaaua ccuaaaucau                                                   20


<210>  787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  787
gggcuagagg gaucucagag                                                   20


<210>  788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  788
cucuagcccu gaucuauugg                                                   20


<210>  789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  789
cagaguauuu gcuuguaguu                                                   20


<210>  790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  790
gguacucggu ucugcccaag                                                   20


<210>  791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  791
uuuaccaugg aguuacaugg                                                   20


<210>  792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  792
gagaaaaaua uuuuuaacaa                                                   20


<210>  793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  793
ccccugccag uaaguauauc                                                   20


<210>  794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  794
uuuccuauca agaaggagag                                                   20


<210>  795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  795
agaaggagag gacuucccug                                                   20


<210>  796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  796
cucugaguac uaggcaacga                                                   20


<210>  797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  797
gcguggcacc accuggcccu                                                   20


<210>  798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  798
cuuguuauuu ugucaucugc                                                   20


<210>  799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  799
uaaaauugug aaagaaccuu                                                   20


<210>  800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  800
guaguuuugc gaaagguucu                                                   20


<210>  801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  801
uaguuaccca uccuucugcc                                                   20


<210>  802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  802
uucugccaga gaaaagggcu                                                   20


<210>  803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  803
gagggagggg gaaacugucc                                                   20


<210>  804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  804
uugggccaau cagagggagg                                                   20


<210>  805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  805
gcucuguuca cagagugccc                                                   20


<210>  806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  806
uuuggaccuc ucuuuacuca                                                   20


<210>  807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  807
uuacaauggg gauagugaaa                                                   20


<210>  808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  808
ccauuguaaa gaugaguaaa                                                   20


<210>  809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  809
caaccgugcc ugguauggug                                                   20


<210>  810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  810
uuauuacugu ggccaguagu                                                   20


<210>  811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  811
ugacuuauuu cacagaguac                                                   20


<210>  812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  812
gacauuguaa aaucaaaaag                                                   20


<210>  813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  813
aaaagggcau ucucccuggg                                                   20


<210>  814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  814
aaacauaaau gagaaaguau                                                   20


<210>  815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  815
aucauuuucu aaggaaagcc                                                   20


<210>  816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  816
uuuucuaagg aaagccucca                                                   20


<210>  817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  817
uuuuuguuca ugugccugga                                                   20


<210>  818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  818
accccucugg ggccaaaugc                                                   20


<210>  819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  819
agagcugggc ucagcacugg                                                   20


<210>  820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  820
ccuuucuuuu auuucuucag                                                   20


<210>  821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  821
gagguaggcu guuagcugaa                                                   20


<210>  822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  822
ucugagagcc uaggagugaa                                                   20


<210>  823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  823
guauuggaag cuagaaaugc                                                   20


<210>  824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  824
aacugcuggg uucacauugc                                                   20


<210>  825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  825
ucaggucauu acaagggccu                                                   20


<210>  826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  826
uuggacagag aggaccugag                                                   20


<210>  827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  827
ugcuuugagg cuauuagaaa                                                   20


<210>  828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  828
caugaagauu cugcaagacu                                                   20


<210>  829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  829
ucaugugauc uugcuuugag                                                   20


<210>  830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  830
auaugagguu aguccauuug                                                   20


<210>  831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  831
ugggacuaug aaaauagggc                                                   20


<210>  832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  832
aaggaggcgu gguuuccuuu                                                   20


<210>  833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  833
ccaagcagca gcugcauggu                                                   20


<210>  834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  834
ucaccaagca gcagcugcau                                                   20


<210>  835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  835
gacccuagaa ugcuccacca                                                   20


<210>  836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  836
ggccaaaucc cagguuuccc                                                   20


<210>  837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  837
aaagaaggac acucuuuggu                                                   20


<210>  838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  838
uucccaugca uauuuuaaua                                                   20


<210>  839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  839
auauacagua uuguuuagug                                                   20


<210>  840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  840
gcuguagaag ugaaaguacc                                                   20


<210>  841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  841
cucuuuuuca acaucaaauu                                                   20


<210>  842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  842
aauuugcuga gauuuaggug                                                   20


<210>  843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  843
cagcaaauuu gauguugaaa                                                   20


<210>  844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  844
uggaaaaaaa ucugugggac                                                   20


<210>  845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  845
gugggacaaa cagugggacc                                                   20


<210>  846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  846
cucacagguc ccacuguuug                                                   20


<210>  847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  847
gggagagaaa aacucaguua                                                   20


<210>  848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  848
uaggcuggcc uuuccugggc                                                   20


<210>  849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  849
ugugcagcac ucagggugug                                                   20


<210>  850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  850
caguuucugg gccaguugaa                                                   20


<210>  851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  851
aacugaguuc aacuggccca                                                   20


<210>  852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  852
ucuguuuagu gucucaaaag                                                   20


<210>  853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  853
ggguaucugc aaggccucac                                                   20


<210>  854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  854
gcaaggccuc acuuccuccu                                                   20


<210>  855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  855
uauguaaccu ugacccugug                                                   20


<210>  856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  856
gagaugucuu gagggaaagg                                                   20


<210>  857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  857
cagauaucau auguaaccuu                                                   20


<210>  858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  858
cacgacaagg agcaguugac                                                   20


<210>  859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  859
gucacuaugu gcuaaaagca                                                   20


<210>  860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  860
gaaaugagag uccaguuagu                                                   20


<210>  861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  861
auccggcacc uaugggacag                                                   20


<210>  862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  862
ggcaccuaug ggacaggaag                                                   20


<210>  863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  863
ggcuccacaa accuugcugg                                                   20


<210>  864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  864
ccuuuuacuu uccugaaguu                                                   20


<210>  865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  865
guuuuuguac uuggccugcu                                                   20


<210>  866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  866
ggcuuucucu gagcaaagac                                                   20


<210>  867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  867
gugagugugu uuuauaaacu                                                   20


<210>  868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  868
cgcccccacc cccuacuccu                                                   20


<210>  869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  869
gaacuauucu cuuaauaucu                                                   20


<210>  870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  870
ugauccaagg uuuucucgga                                                   20


<210>  871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  871
agauauuaag agaauaguuc                                                   20


<210>  872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  872
aagguuuucu cggagccugg                                                   20


<210>  873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  873
gggucacucc uaagaaucca                                                   20


<210>  874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  874
aggauccaga cccaguacac                                                   20


<210>  875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  875
uggauucuua ggagugaccc                                                   20


<210>  876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  876
agacccagua cacacauauc                                                   20


<210>  877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  877
ggagcucaga uuucccacau                                                   20


<210>  878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  878
gagcuccuga uaugugugua                                                   20


<210>  879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  879
ggaagggaaa uaaagacuac                                                   20


<210>  880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  880
cacaccugua aucccagcac                                                   20


<210>  881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  881
uaaauaaaua aagucuauau                                                   20


<210>  882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  882
uguuugggcc cucaaagaau                                                   20


<210>  883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  883
ucccucccuu uuaaaaagug                                                   20


<210>  884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  884
gcucuguuaa acagcugacu                                                   20


<210>  885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  885
gucagcuguu uaacagagca                                                   20


<210>  886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  886
ucugaugaau gggaaagaaa                                                   20


<210>  887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  887
gaugaauggg aaagaaaaaa                                                   20


<210>  888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  888
gaugaucagu cagcuguuua                                                   20


<210>  889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  889
ggggggucaa ggaaggccuu                                                   20


<210>  890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  890
cguuaguuug cucauugcac                                                   20


<210>  891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  891
auucacguuu uuaaaaagau                                                   20


<210>  892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  892
uuuuaaaaac gugaauagau                                                   20


<210>  893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  893
cuccuggggc ugggcgcggu                                                   20


<210>  894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  894
uaacacuaug ggaggccaag                                                   20


<210>  895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  895
gccugucuug gccucccaua                                                   20


<210>  896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  896
cuacuaaaau acaaaaaaaa                                                   20


<210>  897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  897
gccucccggg uucaagcaau                                                   20


<210>  898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  898
cggcucauac ugcaacaucu                                                   20


<210>  899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  899
gggucguggu cuucauuucc                                                   20


<210>  900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  900
gugauugacu uuugugauca                                                   20


<210>  901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  901
cugauggaaa ugaagaccac                                                   20


<210>  902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  902
caaaagucaa ucacugaugg                                                   20


<210>  903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  903
caggaguugc auucagaugg                                                   20


<210>  904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  904
gaaugcaacu ccugugauca                                                   20


<210>  905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  905
ccacacuggg uaaccaggaa                                                   20


<210>  906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  906
ccuuccuggu uacccagugu                                                   20


<210>  907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  907
cagccuucug ccaggccaac                                                   20


<210>  908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  908
cuggugguug aggagucugg                                                   20


<210>  909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  909
agugaugaag caugacaacu                                                   20


<210>  910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  910
cuugauuuag aggcaauagg                                                   20


<210>  911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  911
uuuaaaaaag uguccugaca                                                   20


<210>  912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  912
ugcacagcuu ugggcacacc                                                   20


<210>  913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  913
caaguguccc ugaggaccag                                                   20


<210>  914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  914
ugguccucag ggacacuuga                                                   20


<210>  915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  915
uugacuccuc cugcccagag                                                   20


<210>  916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  916
gccaccugcc ccaggucccc                                                   20


<210>  917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  917
cagagcauug ccccucuccc                                                   20


<210>  918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  918
ugcuuccauc cuucaugcag                                                   20


<210>  919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  919
uucaugcagu gcaugaauaa                                                   20


<210>  920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  920
ccccagggaa uguuuaaguu                                                   20


<210>  921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  921
cugguuugcc gcaguugcug                                                   20


<210>  922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  922
agcaggcaug cugggcggac                                                   20


<210>  923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  923
gcuaagaaaa ugucagacuu                                                   20


<210>  924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  924
ccaaauguua agucugacau                                                   20


<210>  925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  925
agggaucuuu uaaaaauauu                                                   20


<210>  926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  926
cuugauggca uccccaaaug                                                   20


<210>  927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  927
uuuaaaaaua uuuuucuguu                                                   20


<210>  928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  928
uuaacagaaa aauauuuuua                                                   20


<210>  929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  929
uuucuuaccc agucugccuu                                                   20


<210>  930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  930
uuugggaaaa ggaguuugga                                                   20


<210>  931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  931
ugcaggucau uuuccccaca                                                   20


<210>  932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  932
agauguaugc ucuugcauau                                                   20


<210>  933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  933
ggauaccuuu uaccucuugg                                                   20


<210>  934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  934
agucuucugc uccccacacu                                                   20


<210>  935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  935
ggccaauguu augcauuuaa                                                   20


<210>  936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  936
gccagccuca gccucccaaa                                                   20


<210>  937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  937
ccugagguca ggaguucgag                                                   20


<210>  938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  938
uauuugucau guguaaacca                                                   20


<210>  939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  939
cagcuacugg ggagguugag                                                   20


<210>  940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  940
cuugaaccca ggaggcagag                                                   20


<210>  941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  941
ccgcucacug caaccucugc                                                   20


<210>  942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  942
auagugcaau cuccgcucac                                                   20


<210>  943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  943
auuaaagcac guagguuacu                                                   20


<210>  944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  944
aauucagagg uucuuaaccu                                                   20


<210>  945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  945
auuagcagaa uacaaguugc                                                   20


<210>  946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  946
ucuacaaauc aauuagcaga                                                   20


<210>  947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  947
auguaaauaa uuugcauucu                                                   20


<210>  948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  948
ucacacccuu uaguccccgg                                                   20


<210>  949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  949
ccuacuucuu gccugaguag                                                   20


<210>  950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  950
gacaucacuc ccagggcaug                                                   20


<210>  951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  951
cucccagggc augccccguc                                                   20


<210>  952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  952
uguucagcug ugguugucgu                                                   20


<210>  953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  953
cagaguaacc aguaggcagg                                                   20


<210>  954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  954
uuuguuuagu uaaagcucuu                                                   20


<210>  955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  955
gugccaagca ccgugcuaga                                                   20


<210>  956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  956
auaugggguu uguaagagga                                                   20


<210>  957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  957
ggacuggggc ccgcuggggc                                                   20


<210>  958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  958
gugggaguuu aggguuuuaa                                                   20


<210>  959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  959
aacacuuugu gguccuguuu                                                   20


<210>  960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  960
cucagcccac agacuuuccc                                                   20


<210>  961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  961
uaauuaugau gaagggugac                                                   20


<210>  962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  962
uaauuaagau uccccacuga                                                   20


<210>  963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  963
guaauuuaau uacuauuuau                                                   20


<210>  964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  964
ucccuucaua acccgagaag                                                   20


<210>  965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  965
cuucauaacc cgagaagcuu                                                   20


<210>  966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  966
aauucuuuaa agguuugaag                                                   20


<210>  967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  967
ugguaguaca cauaucuaau                                                   20


<210>  968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  968
gcaacccaga guguaacaga                                                   20


<210>  969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  969
guuacacucu ggguugcaga                                                   20


<210>  970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  970
cuagcuuccu uccuuuaaaa                                                   20


<210>  971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  971
cuucccuagg gagcaagagg                                                   20


<210>  972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  972
gaagauugac cauauauuaa                                                   20


<210>  973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  973
ucugaugaaa aggcugaggg                                                   20


<210>  974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  974
uuaucacgaa ucagaugccu                                                   20


<210>  975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  975
cgaaucagau gccucuucuc                                                   20


<210>  976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  976
gaugccucuu cucccaggcu                                                   20


<210>  977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  977
gauucgugau aaggaugagg                                                   20


<210>  978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  978
gugcuggcug agcugagcuu                                                   20


<210>  979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  979
aggacacucc cauugccuuc                                                   20


<210>  980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  980
uagcuucauc ccauacuggc                                                   20


<210>  981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  981
cauacuggcu gugugaucuu                                                   20


<210>  982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  982
cacagccagu augggaugaa                                                   20


<210>  983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  983
uggcugaguu acuuaaccuc                                                   20


<210>  984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  984
auauucuuua ccauggguag                                                   20


<210>  985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  985
cagggauacc ucugaagauc                                                   20


<210>  986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  986
cugugaugcu caaaagucau                                                   20


<210>  987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  987
ucagagguau cccugugaug                                                   20


<210>  988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  988
ugccauauuu cacacugaag                                                   20


<210>  989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  989
cccacacuga aagggaccca                                                   20


<210>  990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  990
aggucaauuu uaccugcuua                                                   20


<210>  991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  991
auuuaagaac aucuuccaaa                                                   20


<210>  992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  992
uccaaaacgg cagcuggucu                                                   20


<210>  993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  993
uuccagaaac cgagcaguac                                                   20


<210>  994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  994
uucacuccuc caugcauuau                                                   20


<210>  995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  995
uguuuugguc agacguauuc                                                   20


<210>  996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  996
gucccuguca ccauaguccu                                                   20


<210>  997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  997
accagggcuc aggcgaagau                                                   20


<210>  998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  998
ucgccugagc ccugguagau                                                   20


<210>  999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  999
ucaagcucug gugaccaaag                                                   20


<210>  1000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1000
agcucuggug accaaagcca                                                   20


<210>  1001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1001
cugcucucug aagccauuuc                                                   20


<210>  1002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1002
gaccgcccag guuuaauuca                                                   20


<210>  1003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1003
ccuuugaggu uucaggagau                                                   20


<210>  1004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1004
ccugaaaccu caaaggugau                                                   20


<210>  1005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1005
uccagucaau ccccaaggcc                                                   20


<210>  1006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1006
ccaaggccuc agacagccac                                                   20


<210>  1007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1007
cccuccuggg guccuguggc                                                   20


<210>  1008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1008
caugacaccu uugucaaaca                                                   20


<210>  1009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1009
gaaauguaga uuuggccugg                                                   20


<210>  1010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1010
acauuucaga uuugaaaugg                                                   20


<210>  1011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1011
aggccaaauc uacauuucag                                                   20


<210>  1012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1012
uuucaaugca uucagggugu                                                   20


<210>  1013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1013
ccucgggcuu guuuucccuu                                                   20


<210>  1014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1014
gugccuucuc uagagcccuc                                                   20


<210>  1015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1015
guuugcaacu uucuagaugu                                                   20


<210>  1016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1016
agaaaguugc aaacagauuu                                                   20


<210>  1017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1017
uuccgccugu gcagcuaaaa                                                   20


<210>  1018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1018
cucccaggcc ccagcauucu                                                   20


<210>  1019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1019
auagucuuca cuacccccuu                                                   20


<210>  1020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1020
ccuaaacuca uuuaauuaug                                                   20


<210>  1021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1021
gggggcaucu ggaaggaaag                                                   20


<210>  1022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1022
ggaaggaaag uuaauacauu                                                   20


<210>  1023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1023
aauauucauu guauaaguaa                                                   20


<210>  1024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1024
cacauacagu guaggggaag                                                   20


<210>  1025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1025
ugcauaaugg acucaugggg                                                   20


<210>  1026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1026
ccaugagucc auuaugcaag                                                   20


<210>  1027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1027
uggguugcag gagguuggcg                                                   20


<210>  1028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1028
ugcuggcucc uaccccgcca                                                   20


<210>  1029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1029
cuuuucaccc cgaggcuucg                                                   20


<210>  1030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1030
cagacacccu uugaccaaag                                                   20


<210>  1031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1031
uccuaagauu ugaggauuca                                                   20


<210>  1032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1032
uaggaagauu uuugucuggu                                                   20


<210>  1033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1033
ucaaaucuua ggaagauuuu                                                   20


<210>  1034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1034
ugaauccuca aaucuuagga                                                   20


<210>  1035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1035
aacuccgcau ggggcuuucu                                                   20


<210>  1036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1036
acaugcacca ugccaugccc                                                   20


<210>  1037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1037
cagaggacaa aacugaggcu                                                   20


<210>  1038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1038
uggcuagggg agcuuuggca                                                   20


<210>  1039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1039
uggcccacaa ccccuucuca                                                   20


<210>  1040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1040
gcuggcagca gagcucccca                                                   20


<210>  1041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1041
acauggggac aguuagcaua                                                   20


<210>  1042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1042
aauaaauggc uaaaacuuaa                                                   20


<210>  1043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1043
cacagauggc augcucccua                                                   20


<210>  1044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1044
gugagauggc acaggcaaac                                                   20


<210>  1045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1045
uacagcuuac ugcacggcua                                                   20


<210>  1046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1046
gagggacagg guaagaccga                                                   20


<210>  1047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1047
uaguugcaug uuagcauaau                                                   20


<210>  1048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1048
auuuuaucuu aguugcaugu                                                   20


<210>  1049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1049
uuugcccccu uaagaguuau                                                   20


<210>  1050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1050
cucgugggaa aggcucaugg                                                   20


<210>  1051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1051
guuuccaggg aggugcguuc                                                   20


<210>  1052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1052
cauccccaaa acacaagccc                                                   20


<210>  1053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1053
ccaaaacaca agcccuccca                                                   20


<210>  1054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1054
uucaggggag ccuguuucgu                                                   20


<210>  1055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1055
gaacaggaaa acgaaacagg                                                   20


<210>  1056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1056
uuacaguaag ccguggggaa                                                   20


<210>  1057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1057
uaccaagugc ucaaugccca                                                   20


<210>  1058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1058
aagaaaggug ggagaaagga                                                   20


<210>  1059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1059
ucucacacag aguugggggc                                                   20


<210>  1060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1060
cacacagagu ugggggcucc                                                   20


<210>  1061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1061
ucuauagugc ccagucuaug                                                   20


<210>  1062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1062
cugugcuggu ggucauaugg                                                   20


<210>  1063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1063
cucaccuguu ugccaucaau                                                   20


<210>  1064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1064
auccccuauc caggccccau                                                   20


<210>  1065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1065
ccuauccagg ccccauggcu                                                   20


<210>  1066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1066
aggccccaug gcuguuggga                                                   20


<210>  1067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1067
cugauguguc uucuaucacu                                                   20


<210>  1068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1068
gagauuccca acagccaugg                                                   20


<210>  1069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1069
cuauuguuuu gccuugucua                                                   20


<210>  1070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1070
uucagaaugu agucuuugug                                                   20


<210>  1071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1071
caaggaauau gcuaugugaa                                                   20


<210>  1072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1072
acauuguugc augcaucuca                                                   20


<210>  1073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1073
caacacauca uaugguugca                                                   20


<210>  1074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1074
uaugguugca ugcauaaagu                                                   20


<210>  1075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1075
auacacugga auauuacuca                                                   20


<210>  1076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1076
auccauacac uggaauauua                                                   20


<210>  1077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1077
caauuuguuu acccauucau                                                   20


<210>  1078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1078
acacaaagac uuguauuuaa                                                   20


<210>  1079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1079
gcuagcuaua uucccagggg                                                   20


<210>  1080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1080
cuacauaugc acucgaauga                                                   20


<210>  1081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1081
ccuugugguu uuaauuugca                                                   20


<210>  1082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1082
uuagucauua gggaaaugca                                                   20


<210>  1083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1083
uuccaugugu uuauuugcca                                                   20


<210>  1084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1084
uucgcucauu uucauugugu                                                   20


<210>  1085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1085
augcaacaca augaaaauga                                                   20


<210>  1086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1086
ggaauaaaua aagcacucuc                                                   20


<210>  1087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1087
gauguauuuu uugcaaaaac                                                   20


<210>  1088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1088
gauaaagaac uuguauccgg                                                   20


<210>  1089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1089
aaggagcugg aauaauuaga                                                   20


<210>  1090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1090
uuucaucaaa ggagcuggaa                                                   20


<210>  1091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1091
uugucaaaau ucaguuaauc                                                   20


<210>  1092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1092
uauaugcaug ggucuaucuc                                                   20


<210>  1093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1093
cuggacuuug uucuauugau                                                   20


<210>  1094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1094
auagaacaaa guccagagau                                                   20


<210>  1095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1095
ugucugucug uacacuaaca                                                   20


<210>  1096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1096
gacuucaaaa cuuguggugu                                                   20


<210>  1097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1097
guuugucaau uucaacaaaa                                                   20


<210>  1098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1098
cagcaggcuu uuuuuguuga                                                   20


<210>  1099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1099
aaaucccagc aggcuuuuuu                                                   20


<210>  1100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1100
aaucaaaauc ccagcaggcu                                                   20


<210>  1101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1101
auagucaaug caaauccaau                                                   20


<210>  1102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1102
auuucucucc cuguuauguu                                                   20


<210>  1103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1103
ugcauuuccc caugguuccu                                                   20


<210>  1104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1104
cuggcaaugc ggcugugauu                                                   20


<210>  1105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1105
cagccgcauu gccagagaua                                                   20


<210>  1106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1106
ucacgucugc cugugacucu                                                   20


<210>  1107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1107
uccucacguc ugccugugac                                                   20


<210>  1108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1108
gggaaaguug caagaucccc                                                   20


<210>  1109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1109
ugcaacuuuc ccugauugug                                                   20


<210>  1110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1110
ccagaacuug agauuucuag                                                   20


<210>  1111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1111
caaguucugg ggaucuugca                                                   20


<210>  1112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1112
cagacucuag gaacccuagc                                                   20


<210>  1113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1113
ggugaacaau cgccaaagaa                                                   20


<210>  1114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1114
ccaaagaaua gaauggaagu                                                   20


<210>  1115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1115
acuuccauuc uauucuuugg                                                   20


<210>  1116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1116
cugagaccuu ucuagcucuu                                                   20


<210>  1117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1117
ucuaguccac auuuuauaga                                                   20


<210>  1118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1118
aguccacauu uuauagauga                                                   20


<210>  1119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1119
auaaaaugug gacuagauga                                                   20


<210>  1120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1120
ggucuucugu ccucaaggcu                                                   20


<210>  1121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1121
caucuccccc cacuuuuuuu                                                   20


<210>  1122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1122
ccccccacuu uuuuuuuuuu                                                   20


<210>  1123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1123
guuggcugug ccagaaaguc                                                   20


<210>  1124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1124
gggggacuug aagaccaaau                                                   20


<210>  1125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1125
aucaacacaa gacauuauua                                                   20


<210>  1126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1126
acacaagaca uuauuaagaa                                                   20


<210>  1127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1127
aaauccccuc uauaaccaga                                                   20


<210>  1128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1128
ccucuauaac cagacucccu                                                   20


<210>  1129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1129
caccaaaaua ccugggaagg                                                   20


<210>  1130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1130
caucucacca aaauaccugg                                                   20


<210>  1131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1131
gggacauggu uuuuaaacca                                                   20


<210>  1132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1132
ucuucccugu aucuuccauu                                                   20


<210>  1133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1133
cuccugcuuu gagcaauuua                                                   20


<210>  1134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1134
uaauuuacua auuaaauugc                                                   20


<210>  1135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1135
uuuuaaagcc auuugugguu                                                   20


<210>  1136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1136
augucgcuaa uggguagcug                                                   20


<210>  1137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1137
cccucuagcc accuccccca                                                   20


<210>  1138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1138
ucccaccucc ccccuccaag                                                   20


<210>  1139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1139
uugcuguuac ccugaauggc                                                   20


<210>  1140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1140
auaguuuuca cagaagaggg                                                   20


<210>  1141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1141
cuacuacauu uuucucuguc                                                   20


<210>  1142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1142
uagaauauca uaaacuguug                                                   20


<210>  1143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1143
uaaacuguug uagauaacug                                                   20


<210>  1144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1144
acaacaguuu augauauucu                                                   20


<210>  1145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1145
ugugaaauuc ccaguuaucu                                                   20


<210>  1146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1146
aacaacccac aaggaacuga                                                   20


<210>  1147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1147
cugagaagua uuuucuaugg                                                   20


<210>  1148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1148
uauggagaaa acaucccuga                                                   20


<210>  1149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1149
gauuuuaaau caucaaguuc                                                   20


<210>  1150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1150
gauuaucuua uggagaaaac                                                   20


<210>  1151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1151
cccacccauu gucuucugug                                                   20


<210>  1152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1152
uuuugaggaa uagaauggga                                                   20


<210>  1153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1153
gauaugcauu uaucucagug                                                   20


<210>  1154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1154
gacacucaaa agaaugcaac                                                   20


<210>  1155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1155
cauuacuggg uauauaccca                                                   20


<210>  1156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1156
uuuggguaua uacccaguaa                                                   20


<210>  1157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1157
uuguuggaca uuuggguugg                                                   20


<210>  1158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1158
agucuaucau uguuggacau                                                   20


<210>  1159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1159
uuuuuuacgg cugcauagua                                                   20


<210>  1160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1160
cuauuauacu gguaggaguu                                                   20


<210>  1161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1161
uaauaacaac uacuaccaau                                                   20


<210>  1162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1162
gaaagaauau uugcaaaguu                                                   20


<210>  1163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1163
ucaccacaac ccuggggaaa                                                   20


<210>  1164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1164
agagaguuua aaccacuuag                                                   20


<210>  1165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1165
acucaacaau ggaauauuau                                                   20


<210>  1166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1166
cagcauaauu uaugacagua                                                   20


<210>  1167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1167
uuguacaugc aucugugauc                                                   20


<210>  1168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1168
gugaucgcau cuccaauuau                                                   20


<210>  1169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1169
cagaugcaug uacaaggaug                                                   20


<210>  1170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1170
caucuccaau uauuuucuua                                                   20


<210>  1171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1171
ccaauuauuu ucuuaggcua                                                   20


<210>  1172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1172
ggagacuuaa aggcguuuuc                                                   20


<210>  1173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1173
ccuugggaau augaauuggu                                                   20


<210>  1174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1174
cacacuuuaa aacacccuuu                                                   20


<210>  1175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1175
cagaugucau uuuacucaug                                                   20


<210>  1176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1176
gggauguugg gaauuuaacc                                                   20


<210>  1177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1177
ccuccuacaa ccaugaguaa                                                   20


<210>  1178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1178
ugcaaaugcu uccauuuccc                                                   20


<210>  1179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1179
accugaaacu uaauaaucau                                                   20


<210>  1180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1180
ugcuuuuaua aaacguguau                                                   20


<210>  1181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1181
aauucuggaa aagcugucuc                                                   20


<210>  1182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1182
acuuggagaa ggucauccaa                                                   20


<210>  1183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1183
uuauccacuu ggagaagguc                                                   20


<210>  1184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1184
ggcagugaaa aauauccuua                                                   20


<210>  1185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1185
uaagcuaggg cauugaaauu                                                   20


<210>  1186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1186
ucuagauggu accuaaggcc                                                   20


<210>  1187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1187
agaggauuac aguuguagug                                                   20


<210>  1188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1188
uccuuuggcc uuagguacca                                                   20


<210>  1189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1189
aaguaacuac agagaauuaa                                                   20


<210>  1190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1190
agccuauggu gugaaaaucc                                                   20


<210>  1191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1191
aaguccacuu cccuuacagu                                                   20


<210>  1192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1192
uuuugaccuc uaaaaaccau                                                   20


<210>  1193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1193
gucagagagg cuaacugcug                                                   20


<210>  1194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1194
caaaggccua acacaauaaa                                                   20


<210>  1195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1195
ggugcaagac cagcuagacc                                                   20


<210>  1196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1196
cagaagcuag uuuggaccug                                                   20


<210>  1197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1197
uuuaaauuuc aguauuuacu                                                   20


<210>  1198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1198
cugcagugcc caagcaacca                                                   20


<210>  1199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1199
cuugaggccc auuaauuugg                                                   20


<210>  1200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1200
auccaaaacc cuaugagaaa                                                   20


<210>  1201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1201
aaaacccuau gagaaacguu                                                   20


<210>  1202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1202
ucugcuuugc cacugguggu                                                   20


<210>  1203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1203
caacaacagc cacccccggg                                                   20


<210>  1204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1204
ccccgggggu ggcuguuguu                                                   20


<210>  1205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1205
cauuuaaucu ccccgggggu                                                   20


<210>  1206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1206
cuuuaaauaa aguuuauugg                                                   20


<210>  1207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1207
acuugaacaa gguauuuaac                                                   20


<210>  1208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1208
aaaccuuuuc uguucccuua                                                   20


<210>  1209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1209
cgcacagaaa ggagcgcuuu                                                   20


<210>  1210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1210
cuacuuuuag gacuccucuc                                                   20


<210>  1211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1211
auuauuucau uauuguauca                                                   20


<210>  1212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1212
ccugugucau cuguguagau                                                   20


<210>  1213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1213
guguagaugu agguaauuug                                                   20


<210>  1214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1214
acacagauga cacaggugau                                                   20


<210>  1215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1215
gccuuaauag ugacuagcuc                                                   20


<210>  1216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1216
gcuccaauuu accucugcau                                                   20


<210>  1217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1217
cacugccccc agacacaagu                                                   20


<210>  1218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1218
uuucugugcu cugagaccca                                                   20


<210>  1219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1219
caagcugggu cucagagcac                                                   20


<210>  1220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1220
ucucaagaca uggugccaag                                                   20


<210>  1221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1221
ccaaacacag cacaauauaa                                                   20


<210>  1222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1222
gacaaucacc aaacacagca                                                   20


<210>  1223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1223
aacaugcugc cuccacaugg                                                   20


<210>  1224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1224
augcucuuau uaauuaauua                                                   20


<210>  1225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1225
agcuaguaca ugguaaaguc                                                   20


<210>  1226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1226
agccacuuaa cuaguuuaag                                                   20


<210>  1227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1227
ggaaaauggc aauaaugcua                                                   20


<210>  1228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1228
auuaugaaaa aguuuucagg                                                   20


<210>  1229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1229
acaugcugac cuaccugugu                                                   20


<210>  1230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1230
acacacaucu acaugcugac                                                   20


<210>  1231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1231
gaaaauaaaa auuccccaaa                                                   20


<210>  1232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1232
cagcacuuug ggaggcagag                                                   20


<210>  1233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1233
gcccgccucu gccucccaaa                                                   20


<210>  1234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1234
ucugagguca gguguucaag                                                   20


<210>  1235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1235
gaggucaggu guucaagacc                                                   20


<210>  1236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1236
ugucucuacu aaaaaauaca                                                   20


<210>  1237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1237
uagcuacucg ggaggcugag                                                   20


<210>  1238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1238
cuugaaccug ggaggcagag                                                   20


<210>  1239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1239
cggcucacug caaccucugc                                                   20


<210>  1240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1240
caccacugca cuccaauuua                                                   20


<210>  1241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1241
uggcuauaau ucaguuuaca                                                   20


<210>  1242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1242
uaggcaguua aauucccaau                                                   20


<210>  1243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1243
cauccuaggc aguuaaauuc                                                   20


<210>  1244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1244
caaaagaugc ccaaagcugc                                                   20


<210>  1245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1245
uuugggauuc uguuuggaag                                                   20


<210>  1246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1246
uaaauuuaac auguauuggg                                                   20


<210>  1247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1247
uguuuagaaa ucauaaauuu                                                   20


<210>  1248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1248
ggucuuuuau cuuguuuaga                                                   20


<210>  1249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1249
aaucaggucu uuuaucuugu                                                   20


<210>  1250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1250
uuaagaaaaa aaaaaaaaag                                                   20


<210>  1251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1251
cuuagacaaa accugcuugu                                                   20


<210>  1252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1252
guggugagag agaaggaggu                                                   20


<210>  1253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1253
ccgaggaguc accugccaug                                                   20


<210>  1254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1254
cugaaucacc gaggagucac                                                   20


<210>  1255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1255
aagagugacc uuagaauugg                                                   20


<210>  1256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1256
guagcaggag ccaaccaauu                                                   20


<210>  1257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1257
uugcuccuuc aguucacguu                                                   20


<210>  1258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1258
agugccaugc ccagcagcca                                                   20


<210>  1259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1259
aggugcugug uuggguccag                                                   20


<210>  1260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1260
cagcucacuc cccgaccuuc                                                   20


<210>  1261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1261
ucucaaaguc agaguccuuu                                                   20


<210>  1262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1262
aggugagaug ugcuaaaucu                                                   20


<210>  1263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1263
caccuugaug guuccugaag                                                   20


<210>  1264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1264
aucugaggag aggagacuaa                                                   20


<210>  1265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1265
gaggagagga gacuaaagac                                                   20


<210>  1266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1266
gggagggguc uuuagucucc                                                   20


<210>  1267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1267
gagaauaaua aaacaacggc                                                   20


<210>  1268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1268
ugaccagaac agcaaccuca                                                   20


<210>  1269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1269
gaauucggag gggaaggcag                                                   20


<210>  1270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1270
gugccaucag cuauugcaag                                                   20


<210>  1271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1271
gcuauugcaa gcugaaugca                                                   20


<210>  1272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1272
uguagaacua ugccucacua                                                   20


<210>  1273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1273
ccccuccccc cuccauggaa                                                   20


<210>  1274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1274
aacacacucc ugccuagccc                                                   20


<210>  1275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1275
uguccuuucu ggucaugccc                                                   20


<210>  1276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1276
uaauccacgc cucuucuaac                                                   20


<210>  1277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1277
acgccucuuc uaaccgguuc                                                   20


<210>  1278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1278
ccuugcauua cuaguaauaa                                                   20


<210>  1279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1279
ggguggaggg caaggaagug                                                   20


<210>  1280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1280
cagcuugugc ccaucgauuu                                                   20


<210>  1281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1281
auuuuccuua auaagauuaa                                                   20


<210>  1282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1282
augggcacaa gcugggauua                                                   20


<210>  1283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1283
uauuaaggaa aaucgauggg                                                   20


<210>  1284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1284
cucaggacuc aggaaacaaa                                                   20


<210>  1285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1285
gccucuguca ccagcaaaua                                                   20


<210>  1286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1286
gugcugaaua cuuggcuccu                                                   20


<210>  1287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1287
ggcuuuagaa ccagaagcuc                                                   20


<210>  1288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1288
ucaugccuca gccucccaaa                                                   20


<210>  1289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1289
cuugagccca agaguucgag                                                   20


<210>  1290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1290
cuacaaaaaa uuagccgggu                                                   20


<210>  1291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1291
ccagcuacug gggaggcuga                                                   20


<210>  1292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1292
ucccaccuca gccuccccag                                                   20


<210>  1293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1293
uccugggcuc aagcaauccu                                                   20


<210>  1294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1294
uggcucacug cagccucauc                                                   20


<210>  1295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1295
uacgacugca uuccagccug                                                   20


<210>  1296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1296
caguguucac accuugcauu                                                   20


<210>  1297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1297
aaggacuuua accuucggga                                                   20


<210>  1298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1298
accggcaggg gcuggguugu                                                   20


<210>  1299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1299
uguugcuuaa agggaaaaaa                                                   20


<210>  1300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1300
aagcuggagc auaguggcac                                                   20


<210>  1301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1301
aucauagcuc acugcagccu                                                   20


<210>  1302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1302
uagcucacug cagccucaaa                                                   20


<210>  1303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1303
uagcuacuug cuugagcuga                                                   20


<210>  1304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1304
caugcuacca ugccuggcuc                                                   20


<210>  1305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1305
uucuaaaagu uucauguugu                                                   20


<210>  1306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1306
acuuuuauca uucuaaaagu                                                   20


<210>  1307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1307
uuuuaaaagc cccuauuucu                                                   20


<210>  1308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1308
aauuccgugg uugcugcuuc                                                   20


<210>  1309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1309
ccuccucaaa agaaaccuuc                                                   20


<210>  1310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1310
agaaagcacu cauaucaacc                                                   20


<210>  1311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1311
acccccggcc uuaaaauaga                                                   20


<210>  1312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1312
cacucugggg auaaaacaca                                                   20


<210>  1313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1313
ccagaguggg auaaaugacu                                                   20


<210>  1314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1314
cuaggguggg agaagugccc                                                   20


<210>  1315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1315
uaucccuagg gugggagaag                                                   20


<210>  1316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1316
ugccccgggg cuccagggcu                                                   20


<210>  1317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1317
cuucucuggc ugauacuggg                                                   20


<210>  1318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1318
gccagagaag agauggcuuu                                                   20


<210>  1319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1319
ugaaaaggaa caaggugucu                                                   20


<210>  1320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1320
cggcucacug caaccuccgc                                                   20


<210>  1321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1321
cuugaaccug ggaggcggag                                                   20


<210>  1322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1322
cagcuacuug ggaggcugag                                                   20


<210>  1323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1323
cuacugaaaa uaccaaaauu                                                   20


<210>  1324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1324
cagcacuuug ggaggccaag                                                   20


<210>  1325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1325
uuugugagua uacacuucag                                                   20


<210>  1326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1326
caccgucuac cuccaacacu                                                   20


<210>  1327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1327
uccccagcau aaauucccua                                                   20


<210>  1328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1328
ccagcauaaa uucccuaccc                                                   20


<210>  1329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1329
ccucauuaau cccuuaguaa                                                   20


<210>  1330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1330
cuuaguaauc ucuauuccau                                                   20


<210>  1331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1331
cuauuccauu uucugucucu                                                   20


<210>  1332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1332
uauaauauug cuccuuuuau                                                   20


<210>  1333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1333
ggcauaucuc auuuagcaca                                                   20


<210>  1334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1334
cauuuagcac aauguaugug                                                   20


<210>  1335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1335
auguuguagc auaugucaaa                                                   20


<210>  1336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1336
auucaucucu ucuuuucuuu                                                   20


<210>  1337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1337
cuucuuuucu uuuuuuuuuu                                                   20


<210>  1338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1338
gucucaggaa aaaaaaaaaa                                                   20


<210>  1339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1339
uaccauugca cuccagccug                                                   20


<210>  1340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1340
cagcucacug caaccuccgc                                                   20


<210>  1341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1341
cuuaagcccg ggaggcggag                                                   20


<210>  1342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1342
cuugacacca ggaguucaag                                                   20


<210>  1343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1343
gcccgccucg gccuccugaa                                                   20


<210>  1344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1344
caagcacuuc aggaggccga                                                   20


<210>  1345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1345
uuuuauggau gcuuggguug                                                   20


<210>  1346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1346
auaaaaagau gaaugaggcc                                                   20


<210>  1347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1347
gcuuaaaucc cugauuucca                                                   20


<210>  1348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1348
cugauuucca uucuuuuggc                                                   20


<210>  1349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1349
gggauuuaag cagauuucua                                                   20


<210>  1350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1350
ugaaauucca cucccaggug                                                   20


<210>  1351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1351
uaugguaagu gugcaacuuu                                                   20


<210>  1352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1352
cuguggaaaa caguuuggca                                                   20


<210>  1353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1353
ucucuacauu cuaacuaaca                                                   20


<210>  1354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1354
aaaaaagcag gcaaacacca                                                   20


<210>  1355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1355
auuaagcugg gggccuuaga                                                   20


<210>  1356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1356
cuucaguaug agguagcagc                                                   20


<210>  1357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1357
caggagagcu cccagcugcu                                                   20


<210>  1358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1358
gugaaaugga ggcaauagca                                                   20


<210>  1359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1359
ccccacagug cugcaaugag                                                   20


<210>  1360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1360
aacgagagaa agcuugucac                                                   20


<210>  1361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1361
gaaaagaauu aaagcccccc                                                   20


<210>  1362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1362
gaagcaacau acauucuguc                                                   20


<210>  1363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1363
cccguggcac agucaagccc                                                   20


<210>  1364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1364
gggcuugacu gugccacggg                                                   20


<210>  1365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1365
cuccaagugc uuccuuugaa                                                   20


<210>  1366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1366
aggcuuuaac uucaguuucc                                                   20


<210>  1367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1367
aaacuauagg agaaauagga                                                   20


<210>  1368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1368
acacauuuga augugguaau                                                   20


<210>  1369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1369
cuaauuacca cauucaaaug                                                   20


<210>  1370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1370
cacucccccg acccaucccc                                                   20


<210>  1371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1371
ccaaucuucu gcccaucuga                                                   20


<210>  1372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1372
ucugcccauc ugagagcguu                                                   20


<210>  1373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1373
gagagcguuu agaugaucug                                                   20


<210>  1374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1374
aaacgcucuc agaugggcag                                                   20


<210>  1375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1375
ucuaaacgcu cucagauggg                                                   20


<210>  1376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1376
gaugauguua auuugaacuu                                                   20


<210>  1377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1377
gaucaucuaa acgcucucag                                                   20


<210>  1378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1378
ucagaucauc uaaacgcucu                                                   20


<210>  1379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1379
aggucucugg aguaacuuac                                                   20


<210>  1380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1380
auccuaggag aggaaauuau                                                   20


<210>  1381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1381
uaggagagga aauuauccca                                                   20


<210>  1382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1382
caccaaaguu cuucuuggcc                                                   20


<210>  1383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1383
augcagaguu cacucaucac                                                   20


<210>  1384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1384
cccaggaauu acgugaggag                                                   20


<210>  1385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1385
ugucuuacuc uucguggcuu                                                   20


<210>  1386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1386
gauggaaaaa uaagacauuu                                                   20


<210>  1387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1387
gauccugucu uacucuucgu                                                   20


<210>  1388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1388
ggguuuaaaa acaaaaaaag                                                   20


<210>  1389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1389
cagcaagggu uauauuucag                                                   20


<210>  1390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1390
gaaggcuggg ugccgagcgu                                                   20


<210>  1391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1391
guuuuaucug agucuuuccc                                                   20


<210>  1392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1392
gagucuuucc cacacuuguu                                                   20


<210>  1393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1393
ccaagucuca acaaggagug                                                   20


<210>  1394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1394
aucaccaagu cucaacaagg                                                   20


<210>  1395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1395
uuuuauaaca caauuaggag                                                   20


<210>  1396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1396
uauuaaggaa auccagaccu                                                   20


<210>  1397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1397
agaccuuggc aguuuagcgg                                                   20


<210>  1398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1398
uuaggugacc uggggacccc                                                   20


<210>  1399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1399
gaguaaaugu gucucucagc                                                   20


<210>  1400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1400
cauguccuca agggcuggac                                                   20


<210>  1401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1401
cuuuccuccg cagccaacau                                                   20


<210>  1402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1402
aggugacccc ugauguuauc                                                   20


<210>  1403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1403
ggggucaccu ugauguuggc                                                   20


<210>  1404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1404
aacauagugu uagugguauu                                                   20


<210>  1405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1405
gaggucaaua gggcgcaagc                                                   20


<210>  1406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1406
cuaugcuucu ugcaauaauu                                                   20


<210>  1407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1407
uaaagguuua acccccuaaa                                                   20


<210>  1408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1408
gcguuuuagg gaggcacaug                                                   20


<210>  1409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1409
ugacucauag gucugaggag                                                   20


<210>  1410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1410
guaagccagg ugaaaugcgc                                                   20


<210>  1411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1411
uguguggacc guagagccac                                                   20


<210>  1412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1412
cacaugaguc ucuggcgggg                                                   20


<210>  1413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1413
guggagccca uggggaugac                                                   20


<210>  1414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1414
ccaugggcuc cacagaugag                                                   20


<210>  1415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1415
ucucagugac acccugagag                                                   20


<210>  1416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1416
cucaaucccg gcuugcccug                                                   20


<210>  1417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1417
cggcuugccc ugugcugcuu                                                   20


<210>  1418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1418
cuguuuuuua uagcuaaagu                                                   20


<210>  1419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1419
gaaguuggcc uaugccuuau                                                   20


<210>  1420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1420
uauaauaagg auguuaucau                                                   20


<210>  1421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1421
uuauuauaag augcaaauug                                                   20


<210>  1422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1422
uacugguuua uggcugagcu                                                   20


<210>  1423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1423
cucuggggcu agauuccccc                                                   20


<210>  1424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1424
agccccagag agauaaaaac                                                   20


<210>  1425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1425
uccagugaau gcaaacauuc                                                   20


<210>  1426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1426
cgccacaucc uccagugaau                                                   20


<210>  1427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1427
cugagggcua auaucccgcc                                                   20


<210>  1428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1428
agucugccac ugcgaagaag                                                   20


<210>  1429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1429
cugguguguu cauucucuua                                                   20


<210>  1430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1430
aaauguaaga gaaugaacac                                                   20


<210>  1431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1431
uagggaaauu augcauuuuc                                                   20


<210>  1432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1432
ucauagggaa auuaugcauu                                                   20


<210>  1433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1433
uauugcaugc aacuggcaaa                                                   20


<210>  1434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1434
uuugauugcc agcuauagaa                                                   20


<210>  1435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1435
aaagaucaua uugcaugcaa                                                   20


<210>  1436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1436
ugucauagca cuuugaaaac                                                   20


<210>  1437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1437
aaaaaaaaaa aaaaaaacaa                                                   20


<210>  1438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1438
uuagcauggg cacucuuggu                                                   20


<210>  1439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1439
cccuucuuug gaaccaagcu                                                   20


<210>  1440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1440
ucucccuucu uuggaaccaa                                                   20


<210>  1441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1441
uuucuccacc acccagcugu                                                   20


<210>  1442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1442
caaguccucu cacuugcuuc                                                   20


<210>  1443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1443
gaagcaagug agaggacuug                                                   20


<210>  1444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1444
ucugaaucaa caccgaguca                                                   20


<210>  1445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1445
gaaucaacac cgagucacag                                                   20


<210>  1446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1446
acaccgaguc acagcuagca                                                   20


<210>  1447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1447
ccaggagcag cccccugagg                                                   20


<210>  1448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1448
agagggaggu aaccaauccc                                                   20


<210>  1449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1449
uuggcugugu ugguuaaaaa                                                   20


<210>  1450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1450
uggaaaaguu ucaccugugg                                                   20


<210>  1451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1451
ucguggaaaa guuucaccug                                                   20


<210>  1452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1452
uuuaaaaaau aaucacagua                                                   20


<210>  1453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1453
caguaauagc agaaggagca                                                   20


<210>  1454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1454
gucuucccag cacacucacu                                                   20


<210>  1455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1455
augcccccua auggcaaugc                                                   20


<210>  1456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1456
uguuucuauu cucuucaagg                                                   20


<210>  1457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1457
aguauauuuu cgaagagcag                                                   20


<210>  1458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1458
cauugaauuc ugacccaagg                                                   20


<210>  1459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1459
ccucuccuac uggaaaucac                                                   20


<210>  1460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1460
guucuauaga cacaaggacc                                                   20


<210>  1461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1461
ucuccuggcc uagggggucc                                                   20


<210>  1462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1462
ucagaagcug uauucacucu                                                   20


<210>  1463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1463
ucuaguuucu guagucuuau                                                   20


<210>  1464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1464
aagaucaagg ccaguaaugu                                                   20


<210>  1465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1465
uugauaguca uuauccucua                                                   20


<210>  1466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1466
aggccaguaa ugucauugag                                                   20


<210>  1467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1467
caaugacauu acuggccuug                                                   20


<210>  1468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1468
ucauagucgu uacagaugag                                                   20


<210>  1469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1469
guaacgacua ugacgaucuc                                                   20


<210>  1470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1470
agacauaaaa aaaugccuca                                                   20


<210>  1471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1471
aucuagacau aaaaaaaugc                                                   20


<210>  1472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1472
auuuauagca caugccuauu                                                   20


<210>  1473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1473
ugguauaugu augggaagua                                                   20


<210>  1474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1474
augcaaacag gcccuuggaa                                                   20


<210>  1475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1475
cuaaaaguca uacauacuau                                                   20


<210>  1476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1476
gugccucagc aaaacauaau                                                   20


<210>  1477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1477
cacacaggcc uugcuuuccu                                                   20


<210>  1478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1478
gucacaagag aacggccggg                                                   20


<210>  1479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1479
uuagcauuua uuuacacgcu                                                   20


<210>  1480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1480
uagaguuucu cccagagcuc                                                   20


<210>  1481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1481
agcaccaaaa aggaauucuu                                                   20


<210>  1482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1482
uguuucuccu ggaagcagga                                                   20


<210>  1483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1483
cucuccccca ugccuacuau                                                   20


<210>  1484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1484
gguguccuuc ccuaucucuc                                                   20


<210>  1485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1485
ucuggugucc uucccuaucu                                                   20


<210>  1486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1486
augccuuuau uacgaaauuc                                                   20


<210>  1487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1487
aauguugugg ccaaauggca                                                   20


<210>  1488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1488
aaaaauucuu aaaucacagc                                                   20


<210>  1489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1489
cagcugggug guggcucacg                                                   20


<210>  1490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1490
cagcaccugg ggaggccaag                                                   20


<210>  1491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1491
uccugccuug gccuccccag                                                   20


<210>  1492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1492
uuugaagcca ggaguuugag                                                   20


<210>  1493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1493
ccccucaaaa aagaaguauu                                                   20


<210>  1494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1494
gagagguaca aauacuucuu                                                   20


<210>  1495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1495
gcaaaaaucu uguagcguuc                                                   20


<210>  1496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1496
uguagcguuc uauucuuuuu                                                   20


<210>  1497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1497
uuuugcuuug agacaugaua                                                   20


<210>  1498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1498
ugucucaaag caaaaugaua                                                   20


<210>  1499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1499
cuaggaacua acuggccugu                                                   20


<210>  1500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1500
uuaggcuguu uguggugugg                                                   20


<210>  1501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1501
uacaccacac cacaccacaa                                                   20


<210>  1502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1502
acccauaagg aagaacuuuu                                                   20


<210>  1503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1503
aagacuguag aagcuugaaa                                                   20


<210>  1504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1504
aaauucccca uuugugcugg                                                   20


<210>  1505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1505
uugacacauu caaauagaca                                                   20


<210>  1506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1506
uucaaugaaa caaccagugc                                                   20


<210>  1507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1507
uggaaggcac ugguuguuuc                                                   20


<210>  1508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1508
gccuucuacu ggucucuugg                                                   20


<210>  1509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1509
auuucaugcc cugcuacacu                                                   20


<210>  1510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1510
uguccauaga aaaguuuugg                                                   20


<210>  1511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1511
uuaacugacu auaagauuua                                                   20


<210>  1512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1512
uauagucagu uaaugauuau                                                   20


<210>  1513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1513
caccuggccu uucuuaaauc                                                   20


<210>  1514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1514
cagcacuuug ggaggcugag                                                   20


<210>  1515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1515
acccgccuca gccucccaaa                                                   20


<210>  1516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1516
ccugagguca ggaguucaag                                                   20


<210>  1517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1517
uguuggccag gcuggucuug                                                   20


<210>  1518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1518
uggcucacug caaccuccgc                                                   20


<210>  1519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1519
ugccauugca cucuagcuug                                                   20


<210>  1520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1520
uuuuuuuuuu uuuuuuuuug                                                   20


<210>  1521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1521
uauagucaau aacauuuucu                                                   20


<210>  1522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1522
uuucucucug ucaucuaaau                                                   20


<210>  1523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1523
aaauucuagc cugucuuuga                                                   20


<210>  1524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1524
aagacaggcu agaauuuaga                                                   20


<210>  1525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1525
cugugggccu cagagaaauu                                                   20


<210>  1526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1526
uccucugcau uccuccaguu                                                   20


<210>  1527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1527
cucacuaaug gauuaaucau                                                   20


<210>  1528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1528
auuagugaga gaugccaacu                                                   20


<210>  1529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1529
uauuacccuc uccuauuguu                                                   20


<210>  1530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1530
uagccccccc auaggaccaa                                                   20


<210>  1531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1531
cuuugaggac agggguuuga                                                   20


<210>  1532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1532
aaccccuguc cucaaaggga                                                   20


<210>  1533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1533
uguaccuauu uauaguuccc                                                   20


<210>  1534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1534
gcauaagcaa auauuuuccc                                                   20


<210>  1535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1535
ucagcauaag caaauauuuu                                                   20


<210>  1536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1536
gagaaagaua auacugcaaa                                                   20


<210>  1537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1537
uucucagauc aucagcauaa                                                   20


<210>  1538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1538
uuacuucucc uguuugcagu                                                   20


<210>  1539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1539
guuagagguc aguucagaag                                                   20


<210>  1540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1540
ccuguuacag gucucuuauc                                                   20


<210>  1541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1541
uuacaaagau uguguuccug                                                   20


<210>  1542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1542
uuguaaagau aagagaccug                                                   20


<210>  1543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1543
uugguguugu uauuuacaag                                                   20


<210>  1544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1544
auguauacuc aucccuacca                                                   20


<210>  1545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1545
cuaccauuug aaaaacaagu                                                   20


<210>  1546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1546
gugguacaca cacuuaaaac                                                   20


<210>  1547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1547
gcauuuugua aagcccacua                                                   20


<210>  1548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1548
uauuaaauaa cugguugcag                                                   20


<210>  1549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1549
gaaauugcua ccaguggaga                                                   20


<210>  1550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1550
cuuccccagc acuuaacuca                                                   20


<210>  1551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1551
acaaauauuu auuagguucc                                                   20


<210>  1552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1552
gccguauggc ucauucauuu                                                   20


<210>  1553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1553
gaggaauuca cucuccagua                                                   20


<210>  1554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1554
gaaauggaca gaaaugcaag                                                   20


<210>  1555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1555
guuuaauuag cacugcuguu                                                   20


<210>  1556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1556
uaaaaaauua acagcagugc                                                   20


<210>  1557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1557
ugaaauuuuc uuaccacuug                                                   20


<210>  1558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1558
accucauccu gaaauuuucu                                                   20


<210>  1559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1559
ugugguauag guacuauuau                                                   20


<210>  1560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1560
ucguguggua uagguacuau                                                   20


<210>  1561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1561
ggaagaagaa auaagaacau                                                   20


<210>  1562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1562
cagcacuuug ggaggccaag                                                   20


<210>  1563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1563
acccaccuug gccucccaaa                                                   20


<210>  1564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1564
ccugagguca ggaguucgag                                                   20


<210>  1565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1565
acauagugaa agcccgucuc                                                   20


<210>  1566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1566
cagcuacucu ggaggcugag                                                   20


<210>  1567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1567
gggaggcgga gguugcagug                                                   20


<210>  1568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1568
cagcucacug caaccuccgc                                                   20


<210>  1569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1569
ugccauugga cuccagccug                                                   20


<210>  1570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1570
caaaaaaaaa aaaaagaaca                                                   20


<210>  1571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1571
uuaucacugu gccuagaaca                                                   20


<210>  1572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1572
cugugccuag aacauaguaa                                                   20


<210>  1573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1573
gcuaauguuu auugagaauu                                                   20


<210>  1574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1574
uaucagcuaa uguuuauuga                                                   20


<210>  1575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1575
aggacgagaa ggguuagguu                                                   20


<210>  1576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1576
cugacugaga accuaacccu                                                   20


<210>  1577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1577
cauuucagaa acaucugggc                                                   20


<210>  1578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1578
gggccuggau cuccaggcac                                                   20


<210>  1579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1579
aggcccagau guuucugaaa                                                   20


<210>  1580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1580
ccaggcaccc gaagaaguuu                                                   20


<210>  1581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1581
cacugagggu ggcaaagcac                                                   20


<210>  1582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1582
cuuugguugu acuuuaaggu                                                   20


<210>  1583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1583
uaucacuuug guuguacuuu                                                   20


<210>  1584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1584
cuugcugcuu uuuuucugug                                                   20


<210>  1585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1585
ccguggccau caagacugga                                                   20


<210>  1586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1586
agacuggaug ucaacacucc                                                   20


<210>  1587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1587
agucuugaug gccacgggga                                                   20


<210>  1588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1588
guuuccuacc uccuacuucc                                                   20


<210>  1589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1589
uugccaugcu gacccaccug                                                   20


<210>  1590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1590
uggcuuuauc auugccaugc                                                   20


<210>  1591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1591
uaacccugag cugugggcuc                                                   20


<210>  1592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1592
ucauccugcc cccaacacau                                                   20


<210>  1593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1593
ugcccccaac acauaggccu                                                   20


<210>  1594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1594
acacaaagga ccgcuuuaaa                                                   20


<210>  1595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1595
cuuguguucc ugaguucuga                                                   20


<210>  1596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1596
gucacucuga aauagaagca                                                   20


<210>  1597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1597
uagagcccaa aggaagcuaa                                                   20


<210>  1598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1598
cuuccuaccu cucaauuggc                                                   20


<210>  1599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1599
gcagggagag agaagcagaa                                                   20


<210>  1600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1600
aaggaaauuc aggcaacuau                                                   20


<210>  1601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1601
cugggggaaa aaucaggcaa                                                   20


<210>  1602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1602
ggcaaauuac uucgucucag                                                   20


<210>  1603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1603
ucaacaggga uguuugauuu                                                   20


<210>  1604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1604
cuguugagga uggucugaga                                                   20


<210>  1605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1605
aacaucccug uugaggaugg                                                   20


<210>  1606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1606
aagggugacu ggcaagaaaa                                                   20


<210>  1607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1607
cagcacuuug ggaggccaag                                                   20


<210>  1608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1608
ccugagguca ggaguuugag                                                   20


<210>  1609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1609
cuugaaccag ggaggcagag                                                   20


<210>  1610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1610
cggcucaccg caaccucugc                                                   20


<210>  1611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1611
cgccacugca cuccagccug                                                   20


<210>  1612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1612
caaaaaaaaa aaagaaagaa                                                   20


<210>  1613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1613
uuuucuuucu uuuuuuuuuu                                                   20


<210>  1614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1614
aaauaaccaa uagcauaacc                                                   20


<210>  1615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1615
uguuagagaa uccaaauaac                                                   20


<210>  1616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1616
cauccuguua gagaauccaa                                                   20


<210>  1617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1617
aaauucaaau ucagugggug                                                   20


<210>  1618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1618
ugucuagaga auggaacaga                                                   20


<210>  1619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1619
guuccauucu cuagacaaga                                                   20


<210>  1620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1620
ccaaugacuu aagugggucu                                                   20


<210>  1621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1621
aaccaaauuc aucuccaaug                                                   20


<210>  1622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1622
auucagguug ugaccuaaau                                                   20


<210>  1623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1623
ucuccgucau aggaauacua                                                   20


<210>  1624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1624
uucugaaaug cauacuuuuc                                                   20


<210>  1625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1625
cucccuagug acccacuaaa                                                   20


<210>  1626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1626
uagccaagcu ugaaaccaca                                                   20


<210>  1627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1627
cagugugaaa aaaacaucau                                                   20


<210>  1628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1628
uagguacuuc acuuaaucuu                                                   20


<210>  1629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1629
uugggcccuu auuauucuga                                                   20


<210>  1630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1630
gaauaauaag ggcccaaaga                                                   20


<210>  1631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1631
cuaaaaugag ugauuacuag                                                   20


<210>  1632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1632
cucauuuuag agaucagaau                                                   20


<210>  1633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1633
uaguaaucac ucauuuuaga                                                   20


<210>  1634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1634
aauuuauaga aucacaagga                                                   20


<210>  1635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1635
caaggaaaau ugauucuauc                                                   20


<210>  1636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1636
auuuuccuug ugauucuaua                                                   20


<210>  1637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1637
uguauauaaa aguauucuau                                                   20


<210>  1638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1638
uauuacgaac cacauggccu                                                   20


<210>  1639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1639
uaauuuaaac uaagauagaa                                                   20


<210>  1640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1640
uaguuuaaau uaggauaucu                                                   20


<210>  1641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1641
agaagcaguc auugucuguu                                                   20


<210>  1642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1642
ugaguuccua accagcagag                                                   20


<210>  1643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1643
ccaguuauuu uggaacuucc                                                   20


<210>  1644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1644
gcuuccuuca cacuauacuc                                                   20


<210>  1645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1645
uacuauuacu uccggggaca                                                   20


<210>  1646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1646
guguccccgg aaguaauagu                                                   20


<210>  1647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1647
ucgucaaugu uaaccucacu                                                   20


<210>  1648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1648
aaaaaaaaaa aaaaucaugu                                                   20


<210>  1649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1649
ugucaacgca uacaaaaccu                                                   20


<210>  1650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1650
uucagguuuu guaugcguug                                                   20


<210>  1651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1651
gaaugcucuu ggaaacucca                                                   20


<210>  1652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1652
gcugaggucu aacugagugc                                                   20


<210>  1653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1653
uggaaucugc ugaggucuaa                                                   20


<210>  1654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1654
uuuaaagaaa acucuuaggc                                                   20


<210>  1655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1655
cugguuuuug aaacaauuau                                                   20


<210>  1656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1656
gccuguuuga gaaauaauug                                                   20


<210>  1657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1657
agcauguuga auaucagccu                                                   20


<210>  1658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1658
uggaccccaa uucuaacaga                                                   20


<210>  1659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1659
guccgggcgc gguggcuuac                                                   20


<210>  1660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1660
cagcacuuug ggaggccgag                                                   20


<210>  1661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1661
cagccacuca ggaggcugag                                                   20


<210>  1662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1662
uggcucacug caaccucuac                                                   20


<210>  1663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1663
ugccauugca cuccagccug                                                   20


<210>  1664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1664
caacaauaau aauaauaaua                                                   20


<210>  1665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1665
gaacagccca caaaaggcuu                                                   20


<210>  1666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1666
aaguggcugg gacucugucc                                                   20


<210>  1667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1667
cucugcaauc ugaaguucca                                                   20


<210>  1668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1668
gaaguuccac ucugcagaga                                                   20


<210>  1669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1669
gccagggguu cucacugugu                                                   20


<210>  1670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1670
augaauggca gaagcaggga                                                   20


<210>  1671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1671
ugguuaucca ugaauggcag                                                   20


<210>  1672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1672
ugacucauca cacagagaga                                                   20


<210>  1673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1673
cacagagaga ugucuuccca                                                   20


<210>  1674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1674
cucuguguga ugagucaaga                                                   20


<210>  1675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1675
uguauggggu uucaaaaguc                                                   20


<210>  1676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1676
cagcacuaug ggaggccuag                                                   20


<210>  1677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1677
acccuccuag gccucccaua                                                   20


<210>  1678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1678
cgagaucagg agauggagac                                                   20


<210>  1679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1679
cgugauccac ccuccuaggc                                                   20


<210>  1680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1680
ggagauggag accauccugg                                                   20


<210>  1681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1681
ccugaucucg ugauccaccc                                                   20


<210>  1682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1682
uggcuaacac ggugaaacgc                                                   20


<210>  1683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1683
acuaaaaaua caaaaaauau                                                   20


<210>  1684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1684
uccugccuca gcuucccaag                                                   20


<210>  1685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1685
cuugaaccca guaggcggag                                                   20


<210>  1686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1686
cgcucuguca cccaggcugg                                                   20


<210>  1687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1687
ucuucacugu ggagaagaac                                                   20


<210>  1688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1688
uuuauccacu ucuguuaucc                                                   20


<210>  1689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1689
acuucuguua uccucuugcc                                                   20


<210>  1690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1690
ucuugccccu uaaaaauccc                                                   20


<210>  1691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1691
cacuuuuaga gauauccacu                                                   20


<210>  1692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1692
cuaaaagugg gauuuuuaag                                                   20


<210>  1693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1693
acuuauuuac aaacugacuc                                                   20


<210>  1694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1694
ugggucuuga gacaaguuca                                                   20


<210>  1695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1695
gcaaggaguu cagcacauuu                                                   20


<210>  1696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1696
cagaaacccu aauggucuua                                                   20


<210>  1697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1697
auuaguuggg acuuccagac                                                   20


<210>  1698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1698
ggguuauuug ucauggaaaa                                                   20


<210>  1699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1699
ccuuuccccu guggcuuuuc                                                   20


<210>  1700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1700
guugguagga agaggcaacu                                                   20


<210>  1701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1701
ugggucugua uguguaagcc                                                   20


<210>  1702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1702
uuuccugugu uagcacauaa                                                   20


<210>  1703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1703
aagggaguau cuuuuccugu                                                   20


<210>  1704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1704
guuaaacaga guuuggugaa                                                   20


<210>  1705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1705
guaagagaga aagcagagaa                                                   20


<210>  1706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1706
ccaccuccau aaaguagaag                                                   20


<210>  1707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1707
cacgacuucu acuuuaugga                                                   20


<210>  1708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1708
gucccagaga gcaggugaaa                                                   20


<210>  1709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1709
uuucacuaag cuagguaauc                                                   20


<210>  1710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1710
agccagaagg uggauaggua                                                   20


<210>  1711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1711
accuucuggc uagauuaccu                                                   20


<210>  1712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1712
uaccuaucca ccuucuggcu                                                   20


<210>  1713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1713
acagcacaca ggugucugag                                                   20


<210>  1714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1714
agaagagaau uagaaacaac                                                   20


<210>  1715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1715
ccaagcagua aaaaauacca                                                   20


<210>  1716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1716
acaaacaggu gguaaaaauu                                                   20


<210>  1717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1717
cagcaaugcu cuauuccuua                                                   20


<210>  1718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1718
gaacagacaa ucacagcaau                                                   20


<210>  1719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1719
gccccaaauu uccugaugua                                                   20


<210>  1720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1720
ggaaauuugg ggcagauuuu                                                   20


<210>  1721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1721
uaaugcagac aaacaaacau                                                   20


<210>  1722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1722
ccuucuuuag gauuuaccgc                                                   20


<210>  1723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1723
uaaagaaggu gauaaauguc                                                   20


<210>  1724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1724
cugggcgagc gguaaauccu                                                   20


<210>  1725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1725
ugcaugguag ccaccaaaag                                                   20


<210>  1726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1726
uguuuuucaa auauaugcuu                                                   20


<210>  1727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1727
uaauuaaugu aguaguaaua                                                   20


<210>  1728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1728
uagcaauauc auaauuaaug                                                   20


<210>  1729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1729
aaaugcaaaa cuugggaaua                                                   20


<210>  1730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1730
gauaagcggu aaccuaguuc                                                   20


<210>  1731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1731
gauggcauaa auuuucaagg                                                   20


<210>  1732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1732
ccugcccauu ucucaaaucu                                                   20


<210>  1733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1733
guuccuccua cccacccgau                                                   20


<210>  1734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1734
gguggguagg aggaacagau                                                   20


<210>  1735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1735
uaagcagccu cauugucuua                                                   20


<210>  1736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1736
cucaugacag cgauggucca                                                   20


<210>  1737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1737
cugucaugag ugaugcccug                                                   20


<210>  1738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1738
gucccauaga gagggcccgu                                                   20


<210>  1739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1739
caaacuagca ggaugacaga                                                   20


<210>  1740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1740
ugcuaguuug ugauguuuuc                                                   20


<210>  1741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1741
gaaaacugcc acacaucuug                                                   20


<210>  1742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1742
ugagcucucu ggguacuacg                                                   20


<210>  1743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1743
uugggccaag ucacaccugu                                                   20


<210>  1744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1744
uaagcaugau uucaaacuca                                                   20


<210>  1745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1745
ugcuuaagau gccaguggcu                                                   20


<210>  1746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1746
cugaccucug agucgucuuc                                                   20


<210>  1747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1747
uacaauuggg cagggguggg                                                   20


<210>  1748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1748
aaacugaugu aaaagcagca                                                   20


<210>  1749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1749
guuuugauuu uuuguuucuu                                                   20


<210>  1750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1750
aguucaacgu caaagcagcc                                                   20


<210>  1751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1751
uuggcugcuu ugacguugaa                                                   20


<210>  1752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1752
cugaagagaa aaccagaacc                                                   20


<210>  1753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1753
ggacucccag uucugcugcu                                                   20


<210>  1754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1754
agaccccggg ccuccugcgg                                                   20


<210>  1755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1755
cagcugcucu cacgcauccc                                                   20


<210>  1756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1756
caccccugag cagagcagcg                                                   20


<210>  1757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1757
cauucccagu ccagcgcuaa                                                   20


<210>  1758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1758
gcuaaagggg ccucgacgac                                                   20


<210>  1759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1759
aacccuuucg uccaaccugc                                                   20


<210>  1760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1760
ugggcaugua ccacguucac                                                   20


<210>  1761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1761
ucuaaagcgg gagccccuaa                                                   20


<210>  1762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1762
cuaugaaaga ucugauacac                                                   20


<210>  1763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1763
uucauaggga ugguagaaaa                                                   20


<210>  1764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1764
gauacacgug cucccuugaa                                                   20


<210>  1765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1765
gaucuuucau agggauggua                                                   20


<210>  1766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1766
aaauacguuu uuccuuucug                                                   20


<210>  1767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1767
accaucgagc uguguucagc                                                   20


<210>  1768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1768
agcuguguuc agccaaguuu                                                   20


<210>  1769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1769
aguucacacg ggucauugua                                                   20


<210>  1770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1770
caugaccgua gaugacgcug                                                   20


<210>  1771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1771
acggucaugg gauaccauua                                                   20


<210>  1772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1772
cauuagcccg cuguuuaauu                                                   20


<210>  1773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1773
cguuauccca uuagcccgcu                                                   20


<210>  1774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1774
uaccaauucc cucuaugugu                                                   20


<210>  1775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1775
gaacacauag agggaauugg                                                   20


<210>  1776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1776
gcuagauggc ucaugccuuu                                                   20


<210>  1777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1777
agcagauuuu ccuaguuguc                                                   20


<210>  1778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1778
cauccucaua ucggcaaagu                                                   20


<210>  1779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1779
ucauaucggc aaaguuccca                                                   20


<210>  1780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1780
gcaaaguucc cacaauuuuu                                                   20


<210>  1781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1781
cauucucuuu uuuucagaca                                                   20


<210>  1782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1782
uaaugaggaa cacacaguua                                                   20


<210>  1783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1783
ucuccugcuu guaguacuuu                                                   20


<210>  1784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1784
caguaccuuu cagcaaacug                                                   20


<210>  1785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1785
cccgccacuu ccuuucaagu                                                   20


<210>  1786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1786
uaaugcuaga agugagaacu                                                   20


<210>  1787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1787
acagaaugcc cugggaaaaa                                                   20


<210>  1788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1788
ucucuuuguu uaggaccuac                                                   20


<210>  1789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1789
gugagaaaua gaauuugcgg                                                   20


<210>  1790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1790
ucauuugaga acaacuuaau                                                   20


<210>  1791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1791
guucagguau guagagaaca                                                   20


<210>  1792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1792
gcacgucaag ccuguuacaa                                                   20


<210>  1793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1793
ucaaguaagu uuuuguaaca                                                   20


<210>  1794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1794
uuuuuuuuua aaugaggaac                                                   20


<210>  1795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1795
ugaauucauc uuacuauugg                                                   20


<210>  1796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1796
uacuauugga aaugugcaug                                                   20


<210>  1797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1797
uaauauaaaa uaacaugcac                                                   20


<210>  1798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1798
agaacucuaa aauuuaaaau                                                   20


<210>  1799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1799
uuuauaagug auaucauguu                                                   20


<210>  1800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1800
cuuauaaaug auauuuugua                                                   20


<210>  1801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1801
uguuggcuag guucucaugu                                                   20


<210>  1802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1802
gcuucagaaa uaauauuuua                                                   20


<210>  1803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1803
gaaggcguca auaagucagg                                                   20


<210>  1804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1804
cccaguaaau uuauuuaacu                                                   20


<210>  1805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1805
aacauaaucu gugauuuauc                                                   20


<210>  1806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1806
gugauuuauc accagauguu                                                   20


<210>  1807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1807
cagauuaugu uugauuuaca                                                   20


<210>  1808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1808
ccagauguuu gcacuccucc                                                   20


<210>  1809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1809
ggugauaaau cacagauuau                                                   20


<210>  1810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1810
aauggggaau ggggaggagu                                                   20


<210>  1811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1811
accauuaauu cugucuguca                                                   20


<210>  1812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1812
ugacagacag aauuaauggu                                                   20


<210>  1813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1813
aaagcuggca uggcacuggg                                                   20


<210>  1814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1814
gucuugagca gcauuuugga                                                   20


<210>  1815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1815
aaaaugcugc ucaagacaga                                                   20


<210>  1816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1816
aaaacacaua caguauaucu                                                   20


<210>  1817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1817
uuucuaaguu cagugacaaa                                                   20


<210>  1818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1818
aguucucaag guaccgcacg                                                   20


<210>  1819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1819
uuucucagug gauuccucua                                                   20


<210>  1820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1820
acugagaaag gauguuggag                                                   20


<210>  1821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1821
uucuaaagua uaaagaaagu                                                   20


<210>  1822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1822
gaggcaagaa uaguuuuauc                                                   20


<210>  1823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1823
acacugggaa cagggacacg                                                   20


<210>  1824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1824
ugucccuguu cccaguguag                                                   20


<210>  1825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1825
cagagguaug uguuuaguaa                                                   20


<210>  1826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1826
auuugcuuua cuaaacacau                                                   20


<210>  1827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1827
guguugucac uuuuacaaau                                                   20


<210>  1828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1828
uuagaaaucu guguugucac                                                   20


<210>  1829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1829
ucugaccagc caguuagguc                                                   20


<210>  1830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1830
aggaagaccc uaucaaaaca                                                   20


<210>  1831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1831
aaacaccuaa aguaaucugu                                                   20


<210>  1832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1832
guagcaucua ggguuccugg                                                   20


<210>  1833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1833
aggguuccug ggaucucaga                                                   20


<210>  1834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1834
caggaacccu agaugcuaca                                                   20


<210>  1835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1835
cagaaccaca aggcaaacca                                                   20


<210>  1836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1836
caggaaauca guggcugauu                                                   20


<210>  1837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1837
guggcugauu ccaaagauuu                                                   20


<210>  1838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1838
gccacugauu uccugagaug                                                   20


<210>  1839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1839
uuggaaucag ccacugauuu                                                   20


<210>  1840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1840
gguuuuguuu uguuuuguuu                                                   20


<210>  1841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1841
ggaaacaaag gcaucagguu                                                   20


<210>  1842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1842
aaaaaucugg aaacaaaggc                                                   20


<210>  1843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1843
gcucuuuggu uuccauguaa                                                   20


<210>  1844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1844
uuuuuacauu auguucuaag                                                   20


<210>  1845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1845
uagaacauaa uguaaaaaag                                                   20


<210>  1846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1846
uugcuuuauc uuagaacaua                                                   20


<210>  1847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1847
uaaacuuuua uuuccuuuaa                                                   20


<210>  1848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1848
auucaaacau aagugaaaaa                                                   20


<210>  1849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1849
cuuagcagaa auccauucaa                                                   20


<210>  1850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1850
gacugaaaac accuuccauu                                                   20


<210>  1851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1851
caaacccugg acauaguuuu                                                   20


<210>  1852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1852
gaaugcccau agaaauaauc                                                   20


<210>  1853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1853
ugaaaaagac ugacuggccu                                                   20


<210>  1854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1854
aaauaaaaaa aaaaauaaaa                                                   20


<210>  1855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1855
uuuauuuuuc uuuguuuuua                                                   20


<210>  1856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1856
aauuaagugc cucuguuuug                                                   20


<210>  1857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1857
uuuacuaugg gagucacuau                                                   20


<210>  1858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1858
aaauauaaag caccauuuag                                                   20


<210>  1859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1859
uaccuucaua ugcaguaaaa                                                   20


<210>  1860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1860
cccuacauuc cagcaucuua                                                   20


<210>  1861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1861
uuuuuuguuc cuuuuuccug                                                   20


<210>  1862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1862
augugacauu cuagcaggcu                                                   20


<210>  1863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1863
guaaugucac acuuuuuugu                                                   20


<210>  1864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1864
ugccaaauua aaaaaauaua                                                   20


<210>  1865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1865
auguaccuuu uuugguagug                                                   20


<210>  1866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1866
aguguuaggc acuauaguau                                                   20


<210>  1867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1867
acaugagugu gcauuuuccu                                                   20


<210>  1868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1868
uaaaccuuuc cccaauguau                                                   20


<210>  1869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1869
aaggcauaga auuuccacua                                                   20


<210>  1870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1870
auuuaaaaau gguaguggaa                                                   20


<210>  1871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1871
uugcacugua gaagcgaaag                                                   20


<210>  1872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1872
uucauuucua uguuaagugu                                                   20


<210>  1873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1873
cauugaggag cauuuuuuaa                                                   20


<210>  1874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1874
gagcagguuu auuuuauacu                                                   20


<210>  1875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1875
cugauuagag aaaagauaca                                                   20


<210>  1876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1876
gagauacaga gguugaguau                                                   20


<210>  1877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1877
uuucucuaau cagagauaca                                                   20


<210>  1878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1878
guaucuuuuc ucuaaucaga                                                   20


<210>  1879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1879
caggcagagu caagugcuau                                                   20


<210>  1880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1880
gccccaguug guguucaaau                                                   20


<210>  1881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1881
ucuuccaugu uaacacaaau                                                   20


<210>  1882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1882
ucauuguauc aauauuagcu                                                   20


<210>  1883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1883
uuguaucaau auuagcuuau                                                   20


<210>  1884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1884
auauuagcuu auauaccugu                                                   20


<210>  1885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1885
uauuauuuuc uucuguuccc                                                   20


<210>  1886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1886
uuugauuguc cacuugacaa                                                   20


<210>  1887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1887
aaugauaaac uuuaagaccu                                                   20


<210>  1888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1888
acuugguugu caaguggaca                                                   20


<210>  1889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1889
ggaucuauuu cuuuuggugc                                                   20


<210>  1890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1890
agaucuacuu gguugucaag                                                   20


<210>  1891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1891
auuucuuuug gugccaguau                                                   20


<210>  1892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1892
ucauaaaaug aacuccuuac                                                   20


<210>  1893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1893
uuguuuaaaa aaaauaaaac                                                   20


<210>  1894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1894
guuuuguuua uaaaauuaaa                                                   20


<210>  1895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1895
uuuuuccuuu aguuuaauuu                                                   20


<210>  1896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1896
ucauuuuucc uuuaguuuaa                                                   20


<210>  1897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1897
uuuuagguag ccauuguugu                                                   20


<210>  1898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1898
augugguuuu aauagaucca                                                   20


<210>  1899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1899
augguucuuu cuacuuguua                                                   20


<210>  1900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1900
auuaaaacca caucgauggu                                                   20


<210>  1901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1901
aaggcacuca uauuuuaaaa                                                   20


<210>  1902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1902
uuugguuuua aaauaugagu                                                   20


<210>  1903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1903
auuggaaagg aagaaaaaag                                                   20


<210>  1904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1904
cuaugagcua aaugucuguc                                                   20


<210>  1905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1905
auucugucua uagaggguua                                                   20


<210>  1906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1906
aaagacuguu uuuccuccuc                                                   20


<210>  1907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1907
uguacaguuu uauuuuauaa                                                   20


<210>  1908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1908
guauggggca auacuauugc                                                   20


<210>  1909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1909
ugcauucaaa cggugagaac                                                   20


<210>  1910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1910
caugggacua gaaaaaaauc                                                   20


<210>  1911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1911
uacagggagu ggggcuggag                                                   20


<210>  1912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1912
cccuccagcc ccacucccug                                                   20


<210>  1913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1913
uuauucaaca cucgaucacu                                                   20


<210>  1914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1914
aguguugaau aaugauauaa                                                   20


<210>  1915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1915
cugugccauu uuuucaugug                                                   20


<210>  1916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1916
uacaaauuuc acauuuguaa                                                   20


<210>  1917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1917
cacuguccac aggagaagcc                                                   20


<210>  1918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1918
cggggcgcag cggcacggga                                                   20


<210>  1919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1919
cuccguccag cuccccgggc                                                   20


<210>  1920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1920
ccuuuugccu ccucgucgga                                                   20


<210>  1921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1921
cuuccuuagc uucggagacu                                                   20


<210>  1922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1922
uugagcugcc uggaggccgc                                                   20


<210>  1923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1923
cggccggggg caggucgaac                                                   20


<210>  1924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1924
agcucgagaa ggaguucgac                                                   20


<210>  1925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1925
ucuaugcggu ccgacucgcc                                                   20


<210>  1926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1926
cggagaacgg ggacgaggag                                                   20


<210>  1927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1927
gguugggguc guucucgcuc                                                   20


<210>  1928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1928
ucccccauga cggucaaguc                                                   20


<210>  1929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1929
gccccuccuc ccucccagcc                                                   20


<210>  1930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1930
auggcgggag gcuccauagc                                                   20


<210>  1931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1931
aauggcuaug gagccucccg                                                   20


<210>  1932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1932
cccgagugcc uuugacaggg                                                   20


<210>  1933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1933
cuuccgcccc caggcgcucu                                                   20


<210>  1934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1934
cuuggacccc caccgcauag                                                   20


<210>  1935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1935
agagaggcuu ccggccuggc                                                   20


<210>  1936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1936
guaucgagag aggcuuccgg                                                   20


<210>  1937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1937
ugguauucuu agcagguuaa                                                   20


<210>  1938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1938
cauggagagg uggcugggaa                                                   20


<210>  1939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1939
cuucaggacu aggugcagaa                                                   20


<210>  1940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1940
acuuagaaag cgaacacgga                                                   20


<210>  1941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1941
augaguguuc ugugcguguu                                                   20


<210>  1942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1942
uuaccugcaa aauaauacaa                                                   20


<210>  1943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1943
auguuuaauc acugaggcgg                                                   20


<210>  1944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1944
cugaggcggg caucagcaau                                                   20


<210>  1945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1945
gcaauugcuu auuuauguuc                                                   20


<210>  1946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1946
auuggaccaa uauuuacugg                                                   20


<210>  1947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1947
uccugccauu aaacucaguu                                                   20


<210>  1948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1948
aauccccaaa gcagaaaaau                                                   20


<210>  1949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1949
ccaaagcaga aaaauccuga                                                   20


<210>  1950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1950
ugaccaguuc uggcuugagg                                                   20


<210>  1951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1951
ucaagccaga acuggucagg                                                   20


<210>  1952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1952
gcuguaguuu ggggcaagcc                                                   20


<210>  1953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1953
caucuccaug ugccucuguu                                                   20


<210>  1954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1954
ccaugugccu cuguuuccuc                                                   20


<210>  1955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1955
cagcuuucua uuccccccug                                                   20


<210>  1956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1956
aaaaagggga agaaggucaa                                                   20


<210>  1957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1957
uuagggccau agaacauugu                                                   20


<210>  1958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1958
acaauuagug uguuucaggc                                                   20


<210>  1959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1959
ucccacaguc ugggguguga                                                   20


<210>  1960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1960
gugaguccca auuuugguuc                                                   20


<210>  1961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1961
caaagaaugu uuaaaaaauc                                                   20


<210>  1962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1962
gaaagaaaaa cuucauucag                                                   20


<210>  1963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1963
gaaugaaguu uuucuuucag                                                   20


<210>  1964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1964
guuaaaucug aaugaaguuu                                                   20


<210>  1965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1965
aaucuuuagg aguugucccc                                                   20


<210>  1966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1966
uuaggaguug ucccccgguc                                                   20


<210>  1967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1967
uaguuuaagg aacaguuaaa                                                   20


<210>  1968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1968
uccuccucau uguuuugaga                                                   20


<210>  1969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1969
ugcgcccucg gcugggacuc                                                   20


<210>  1970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1970
uucuguuucu uucucaacug                                                   20


<210>  1971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1971
ccccaaauga aauauuuugu                                                   20


<210>  1972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1972
ccccauauau auuuaauuua                                                   20


<210>  1973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1973
ucguccuuug gcuaccauua                                                   20


<210>  1974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1974
cugggaaguu uuguuuuucu                                                   20


<210>  1975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1975
accagggagg uuaagaguga                                                   20


<210>  1976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1976
auuauaugau gccuccauuu                                                   20


<210>  1977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1977
uauaauugau uaauuccuca                                                   20


<210>  1978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1978
cacucaauau aucucacucc                                                   20


<210>  1979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1979
cacuccuggg uaaaucucuu                                                   20


<210>  1980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1980
cuuaaacaag auuagauggu                                                   20


<210>  1981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1981
uguuuaagag auuuacccag                                                   20


<210>  1982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1982
aaucuuguuu aagagauuua                                                   20


<210>  1983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1983
uaccaucuaa ucuuguuuaa                                                   20


<210>  1984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1984
uucugccuuu uuucccccuu                                                   20


<210>  1985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1985
cauuaucugc cuauuuuugu                                                   20


<210>  1986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1986
gccuauuuuu guuugccucc                                                   20


<210>  1987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1987
gguuccaacu acaugauccu                                                   20


<210>  1988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1988
uguaguugga accagauagu                                                   20


<210>  1989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1989
ucuguggcuu ccuccuuguc                                                   20


<210>  1990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1990
agggaggaca aggaggaagc                                                   20


<210>  1991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1991
cugggugacu aucauuccua                                                   20


<210>  1992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1992
uuccuauuua gccugacgau                                                   20


<210>  1993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1993
ucaggcuaaa uaggaaugau                                                   20


<210>  1994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1994
gaguugggca aguaaaaaga                                                   20


<210>  1995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1995
uuuuacuugc ccaacucaga                                                   20


<210>  1996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1996
gacaaaucuu uuuacuugcc                                                   20


<210>  1997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1997
aaguccuuaa cacguucauc                                                   20


<210>  1998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1998
cuccaaaugc cuuaaaauua                                                   20


<210>  1999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  1999
auugaaaucc aggacuagac                                                   20


<210>  2000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2000
auguuuuaua agguaaaaua                                                   20


<210>  2001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2001
aggacuagac ucauaauuag                                                   20


<210>  2002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2002
augacuacaa uucauggcac                                                   20


<210>  2003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2003
guggcauaca gcacuacauc                                                   20


<210>  2004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2004
aggaucucau uuguauccuu                                                   20


<210>  2005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2005
uugauguagu gcuguaugcc                                                   20


<210>  2006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2006
cauuuguauc cuuucaaaaa                                                   20


<210>  2007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2007
uuucaaaaag gcuuaaauga                                                   20


<210>  2008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2008
uaaacuuuuu uucagagcca                                                   20


<210>  2009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2009
cauaacuggc ucugaaaaaa                                                   20


<210>  2010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2010
ugcuacagua uguuaacacu                                                   20


<210>  2011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2011
caguguuaac auacuguagc                                                   20


<210>  2012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2012
uccccucucu cucauacauc                                                   20


<210>  2013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2013
ggucagagaa aauggcauuu                                                   20


<210>  2014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2014
uauaaugagc auacaacaua                                                   20


<210>  2015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2015
cauuuuagua uucccaucaa                                                   20


<210>  2016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2016
acuagauauu cuagaucaug                                                   20


<210>  2017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2017
aguugauggg aauacuaaaa                                                   20


<210>  2018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2018
agaauaucua guugauggga                                                   20


<210>  2019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2019
ugagggcagc uaguguaauc                                                   20


<210>  2020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2020
uaaugucaau gagaagggcu                                                   20


<210>  2021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2021
uaacagcccu ucucauugac                                                   20


<210>  2022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2022
uuagucucaa ucguaacagc                                                   20


<210>  2023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2023
uuugcuauua guggacuggu                                                   20


<210>  2024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2024
guauuucacu cagcucaugc                                                   20


<210>  2025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2025
gugagcacug uaauauaaua                                                   20


<210>  2026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2026
auaaaugugu uacuugccau                                                   20


<210>  2027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2027
uugaugauuu agaaagacug                                                   20


<210>  2028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2028
aagauguuau gaacaaagua                                                   20


<210>  2029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2029
ucaaagaugu uaugaacaaa                                                   20


<210>  2030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2030
auuccagucu uucuaaauca                                                   20


<210>  2031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2031
auguagcccu aauuuugcca                                                   20


<210>  2032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2032
auaaaucaau guagcccuaa                                                   20


<210>  2033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2033
gaguaaauga agaauauuau                                                   20


<210>  2034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2034
acuucucaau uugagagccu                                                   20


<210>  2035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2035
ccguaaaugc ccaaugaggc                                                   20


<210>  2036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2036
aaacaauccc cguaaaugcc                                                   20


<210>  2037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2037
aaaggguuaa aaucagcuau                                                   20


<210>  2038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2038
gcuauuagcc caccuacugg                                                   20


<210>  2039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2039
caugacuuuu ucacauuggu                                                   20


<210>  2040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2040
aagccucaag auucagaaga                                                   20


<210>  2041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2041
ugaggcuuag aucacaugac                                                   20


<210>  2042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2042
acuagauugu aacucuggga                                                   20


<210>  2043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2043
aguggauaau agagcuaggc                                                   20


<210>  2044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2044
cagaguuaca aucuagugga                                                   20


<210>  2045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2045
aaugacuauc ccagaguuac                                                   20


<210>  2046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2046
guaaaaugag cauaaaaaca                                                   20


<210>  2047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2047
ggucgaaugu gaaugugagu                                                   20


<210>  2048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2048
ccccugguag uaaugaaaac                                                   20


<210>  2049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2049
gguuuguucu agagcuuucu                                                   20


<210>  2050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2050
agcucagacu uuccuaccag                                                   20


<210>  2051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2051
aacucccagc ccucaggaag                                                   20


<210>  2052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2052
cuucccucca aaaguggcuc                                                   20


<210>  2053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2053
ggggccugca uggggcugug                                                   20


<210>  2054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2054
gugaccuaac ccaggcuuag                                                   20


<210>  2055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2055
gcucccuucc cccaagcugg                                                   20


<210>  2056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2056
uagguaacaa agaguuauug                                                   20


<210>  2057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2057
ggucucaggg ugcaugcccu                                                   20


<210>  2058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2058
gaagagcagg gcaugcaccc                                                   20


<210>  2059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2059
uguaaauggu aucugaagag                                                   20


<210>  2060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2060
cccucccauc uaaaaacagu                                                   20


<210>  2061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2061
aaaaacaguc ccccuuagag                                                   20


<210>  2062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2062
ugcucuuugu uauucucucu                                                   20


<210>  2063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2063
aauuuuuauu ugaaaguaaa                                                   20


<210>  2064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2064
cugcccaccc ccuaaccuuu                                                   20


<210>  2065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2065
ugcauggcua aaagguuagg                                                   20


<210>  2066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2066
uucagaaaac auuuguauaa                                                   20


<210>  2067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2067
ccaccaccac caccaccacc                                                   20


<210>  2068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2068
ucaccaccac caccaccacc                                                   20


<210>  2069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2069
ccaccaccac caccacuacc                                                   20


<210>  2070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2070
ccaccaacac caccaucacc                                                   20


<210>  2071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2071
ccaccaccac caccaccauc                                                   20


<210>  2072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2072
ccaccaccac caccaccauc                                                   20


<210>  2073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2073
ccaccaccau caccaccacc                                                   20


<210>  2074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2074
ccgccaucac caccaccauc                                                   20


<210>  2075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2075
ccaguaccau caccgccauc                                                   20


<210>  2076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2076
cuaccaccac caccaucacc                                                   20


<210>  2077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2077
ccaccaccac cauuaccacc                                                   20


<210>  2078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2078
cuaccaccac caccaccauc                                                   20


<210>  2079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2079
ccaccaccac cauuaccacc                                                   20


<210>  2080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2080
cuaccaccac caccaccauc                                                   20


<210>  2081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2081
ccaccaccac cauuaccacc                                                   20


<210>  2082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2082
ccaccaucac caccaccacc                                                   20


<210>  2083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2083
ucaccaccau caccaccacc                                                   20


<210>  2084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2084
ccaucaucac caccaucacc                                                   20


<210>  2085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2085
ccaccaguac caucaccauc                                                   20


<210>  2086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2086
ccaucaccac caguaccauc                                                   20


<210>  2087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2087
ccaucaccau caccaccagu                                                   20


<210>  2088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2088
ccaguaccau caccaucacc                                                   20


<210>  2089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2089
cuaccaccac caccaucacc                                                   20


<210>  2090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2090
ccaccaccac cauuaccacc                                                   20


<210>  2091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2091
ccaccaccac cauuaccacc                                                   20


<210>  2092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2092
ccaccaucac caccaccacc                                                   20


<210>  2093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2093
ucaccaccau caccaccacc                                                   20


<210>  2094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2094
ccaucaucac caccaucacc                                                   20


<210>  2095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2095
ccaccaguac caucaccauc                                                   20


<210>  2096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2096
ccaucaccac caguaccauc                                                   20


<210>  2097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2097
ccaucaccau caccaccagu                                                   20


<210>  2098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2098
ccaguaccau caccaucacc                                                   20


<210>  2099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2099
cuaccaccac caccaucacc                                                   20


<210>  2100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2100
ccaccaccac cauuaccacc                                                   20


<210>  2101
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2101
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2102
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2102
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgacgcgucc ucgagcagaa gcaucaaag                              99


<210>  2103
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2103
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgcuccguuc gagcagaagc aucaaag                                97


<210>  2104
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2104
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcccu cuucggaggg aagcaucaaa g                                      91


<210>  2105
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2105
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcagga guuucuaugg aaacccugaa gcaucaaag                              99


<210>  2106
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2106
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2107
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2107
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcg cuugcgcaga agcaucaaag                                        90


<210>  2108
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2108
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2109
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2109
uacuggcgcu uuuaucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2110
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2110
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga cuucgguccg auaaauaaga agcaucaaag                 110


<210>  2111
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2111
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcacau gaggauuacc caugugaagc aucaaag                                97


<210>  2112
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2112
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucgugaga aauccgauaa auaagaagca ucaaag                     106


<210>  2113
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2113
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugca ugucuaagac agcagaagca ucaaag                                 96


<210>  2114
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2114
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccga agcaucaaag                                        90


<210>  2115
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2115
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaauc cauugcacuc cggauugaag caucaaag                               98


<210>  2116
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2116
uacuggcgcu uuucucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2117
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2117
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2118
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2118
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cguuugcggc uacgagcaga agcaucaaag                            100


<210>  2119
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2119
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagag auaaauaaga agcaucaaag                            100


<210>  2120
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2120
uacggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2121
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2121
uacuggcgcc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2122
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2122
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaucggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2123
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2123
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2124
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2124
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagaa auccgauaaa uaagaagcau caaag                      105


<210>  2125
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2125
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggagagaaau ccgauaaaua agaagcauca aag                        103


<210>  2126
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2126
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gagauaaaua agaagcauca aag                        103


<210>  2127
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2127
uacuggcgcu uuuaucucau uacuuuggag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag aguauccgau aaauaagaag caucaaag                   108


<210>  2128
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2128
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2129
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2129
agcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cggagagaaa ugccgauaaa uaagaagcau caaag                      105


<210>  2130
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2130
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaauaagaa gcaucaaag                  109


<210>  2131
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2131
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uguaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2132
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2132
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggacuucggu ccgauaaaua agcgcaucaa ag                         102


<210>  2133
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2133
uacuggcgcu uuucucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2134
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2134
guggcgcuuu uaucucauua cuuugagagc caucaccagc gacuaugucg uauggguaaa       60

gcgcuuauuu aucggagaga aauccgauaa auaagaagca ucaaag                     106


<210>  2135
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2135
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaccuuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag                 110


<210>  2136
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2136
gauggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2137
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2137
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaagaagca ucaaag                     106


<210>  2138
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2138
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaucuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2139
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2139
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aaggcuuauu uaucggagag aaauccgaua aaaagaagca ucaaag                     106


<210>  2140
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2140
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaaagaagc aucaaag                    107


<210>  2141
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2141
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2142
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2142
cggcgcuuuu cucgcauuac uuugagagcc aucaccagcg acuaugucgu auggguaaag       60

cgcuuauugu aucgagagau aaauaagaag caucaaag                               98


<210>  2143
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2143
cacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2144
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2144
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau guaucggcuu cggccgauac auaagaagca ucaaag                     106


<210>  2145
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2145
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uguaucggcu ucggccgaua cauaagaagc aucaaag                    107


<210>  2146
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2146
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggug       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2147
<211>  64
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2147
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaag                                                                    64


<210>  2148
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2148
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

ag                                                                      62


<210>  2149
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2149
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

agcgcuuauu uaucggcuuc ggccgauaaa uaagaagcau caaag                      105


<210>  2150
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2150
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuaca cugggaucgc ugaauuagag aucggcgucc uuucauucua uauacuuugg      120

aguuuuaaaa ugucucuaag uacagaagca ucaaag                                156


<210>  2151
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2151
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuucggucgu auggguaaag       60

cgcuuauuua ucggcuucgg ccgauaaaua agaagcauca aag                        103


<210>  2152
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2152
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau uuaucggcuu cggccgauaa auaagaagca ucaaag                     106


<210>  2153
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2153
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2154
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2154
uacuggcgcu uuuaucucau uacuuugaga gccaugcucc accagcgacu augucguaug       60

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              112


<210>  2155
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2155
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgggguu aggguuaggg uuagggaagc aucaaag                                97


<210>  2156
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2156
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcggaggg agggagggag agggaaagca ucaaag                                 96


<210>  2157
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2157
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcguuggg uuaggguuag gguuagggaa aagcaucaaa g                          101


<210>  2158
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2158
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccgg aagcaucaaa g                                      91


<210>  2159
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2159
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccugc ucaguacgag aggaaccgca ggaagcauca aag                        103


<210>  2160
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2160
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2161
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2161
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2162
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2162
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2163
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2163
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2164
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2164
uacuggcgcc uuuaucugca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2165
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2165
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2166
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2166
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2167
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2167
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2168
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2168
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2169
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2169
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2170
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2170
uacuggcgcc uuuaucauca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2171
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2171
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg ccggcauggu      120

cccagccucc ucgcuggcgc cggcugggca acauuccgag gggaccgucc ccucgguaau      180

ggcgaauggg accc                                                        194


<210>  2172
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2172
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2173
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2173
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga aauccgauaa auaagaagca ucaaag                     106


<210>  2174
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2174
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2175
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2175
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccgga cuucgguccg gaagcaucaa ag                                     92


<210>  2176
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2176
uacuggcgcu uuuaucggau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2177
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2177
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2178
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2178
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2179
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2179
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2180
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2180
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gucggcaugg      120

caucuccacc uccucgcggu ccgaccuggg cauccgaagg aggacgcacg uccacucgga      180

uggcuaaggg agagcca                                                     197


<210>  2181
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2181
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggcg caucaaag                                          88


<210>  2182
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2182
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaguu uuggccggca      120

uggucccagc cuccucgcug gcgccggcug ggcaacaugc uucggcaugg cgaaugggac      180

cccggg                                                                 186


<210>  2183
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2183
gauggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2184
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2184
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2185
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2185
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucuuacg gacuucgguc cguaagagca ucaaag                                 96


<210>  2186
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2186
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucggacg accucucggu cguccgagca ucaaag                                 96


<210>  2187
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2187
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc ugucaccgga      120

ugugcuuucc ggucugauga guccgugagg acgaaacagg                            160


<210>  2188
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2188
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2189
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2189
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2190
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2190
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucaggug ggacgaccuc ucggucgucc uaucugagca ucaaag                     106


<210>  2191
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2191
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagga uggccggcau      120

ggucccagcc uccucgcugg cgccggcugg gcaacaccuu cggguggcga augggac         177


<210>  2192
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2192
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2193
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2193
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguacugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2194
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2194
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgugag aaauccgaua aauaagaagc aucaaag                    107


<210>  2195
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2195
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2196
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2196
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2197
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2197
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2198
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2198
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2199
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2199
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2200
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2200
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2201
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2201
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2202
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2202
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2203
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2203
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2204
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2204
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2205
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2205
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2206
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2206
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2207
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2207
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2208
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2208
gauggccggc auggucccag ccuccucgcu ggcgccggcu gggcaacacc uucggguggc       60

gaaugggacu acuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc      120

guauggguaa agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag         177


<210>  2209
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2209
ggccggcaug gucccagccu ccucgcuggc gccggcuggg caacauuccg aggggaccgu       60

ccccucggua auggcgaaug ggacccuacu ggcgcuuuua ucucauuacu uugagagcca      120

ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau      180

aagaagcauc aaag                                                        194


<210>  2210
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2210
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagcgca ucaaag                                 96


<210>  2211
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2211
cgugguuagg gccacguuaa auaguugcuu aagcccuaag cguugaucuu cggaucaggu       60

gcaauacugg cgcuuuuauc ucauuacuuu gagagccauc accagcgacu augucguaug      120

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              172


<210>  2212
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2212
gggucggcau ggcaucucca ccuccucgcg guccgaccug ggcauccgaa ggaggacgca       60

cguccacucg gauggcuaag ggagagccau acuggcgcuu uuaucucauu acuuugagag      120

ccaucaccag cgacuauguc guauggguaa agcgcuuauu uaucggagag aaauccgaua      180

aauaagaagc aucaaag                                                     197


<210>  2213
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2213
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc aguacugaug      120

aguccgugag gacgaaacga guaagcucgu cuacuggcgc uuuuaucuca u               171


<210>  2214
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2214
uacuggcgcc uuuaucucau uacuuuagag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2215
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2215
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgu acuggcgcuu       60

uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu      120

uaucggagag aaauccgaua aauaagaagc aucaaag                               157


<210>  2216
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2216
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugcgca ucaaag                     106


<210>  2217
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2217
uacuggcgcc uuuaucucau uacuuuagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2218
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2218
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagca uuccucagaa      120

aaugacaaac cuguggggcg uaaguagauc uucggaucua ugaucgugca gacguuaaaa      180

ucaggu                                                                 186


<210>  2219
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2219
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucgcgu guagcgaagc a               171


<210>  2220
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2220
cauuccucag aaaaugacaa accugugggg cguaaguaga ucuucggauc uaugaucgug       60

cagacguuaa aaucagguua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2221
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2221
uuuuggccgg caugguccca gccuccucgc uggcgccggc ugggcaacau gcuucggcau       60

ggcgaauggg accccgggua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2222
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2222
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgc guguagcgaa       60

gcauacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2223
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2223
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gagccccgcu      120

gaugaggucg gggagaccga aagggacuuc ggucccuacg gggcuccc                   168


<210>  2224
<211>  144
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2224
ccacccccac caccaccccc acccccacca ccacccuacu ggcgcuuuua ucucauuacu       60

uugagagcca ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa      120

uccgauaaau aagaagcauc aaag                                             144


<210>  2225
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2225
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucg                               157


<210>  2226
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2226
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg ugguuagggc      120

cacguuaaau aguugcuuaa gcccuaagcg uugaucuucg gaucaggugc aa              172


<210>  2227
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2227
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg caauaaagcg      120

guuacaagcc cgcaaaaaua gcagaguaau gucgcgauag cgcggcauua augcagcuuu      180

auug                                                                   184


<210>  2228
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2228
uacuggcgcu uuuaucucau uacuauuauc ucauuacuuu gagagccauc accagcgacu       60

augucguaug gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa      120

ag                                                                     122


<210>  2229
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2229
ggcaauaaag cgguuacaag cccgcaaaaa uagcagagua augucgcgau agcgcggcau       60

uaaugcagcu uuauuguacu ggcgcuuuua ucucauuacu uugagagcca ucaccagcga      120

cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau aagaagcauc      180

aaag                                                                   184


<210>  2230
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2230
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagac ccgcaaggcc      120

gacggcaucc gccgccgcug gugcaagucc agccgccccu ucgggggcgg gcgcucaugg      180

guaac                                                                  185


<210>  2231
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2231
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aag                                                                     63


<210>  2232
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2232
gggagccccg cugaugaggu cggggagacc gaaagggacu ucggucccua cggggcuccc       60

uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua      120

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   168


<210>  2233
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2233
ccaguacuga ugaguccgug aggacgaaac gaguaagcuc gucuacuggc gcuuuuaucu       60

cauuacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2234
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2234
acccgcaagg ccgacggcau ccgccgccgc uggugcaagu ccagccgccc cuucgggggc       60

gggcgcucau ggguaacuac uggcgcuuuu aucucauuac uuugagagcc aucaccagcg      120

acuaugucgu auggguaaag cgcuuauuua ucggagagaa auccgauaaa uaagaagcau      180

caaag                                                                  185


<210>  2235
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2235
ccugucaccg gaugugcuuu ccggucugau gaguccguga ggacgaaaca gguacuggcg       60

cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg uaaagcgcuu      120

auuuaucgga gagaaauccg auaaauaaga agcaucaaag                            160


<210>  2236
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2236
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag                            100


<210>  2237
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2237
guacuggcgc uuuuaucuga uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcuccc ucuucggagg gagcaucaaa g                                      91


<210>  2238
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2238
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2239
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2239
acuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2240
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2240
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2241
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2241
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2242
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2242
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2243
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2243
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2244
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2244
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2245
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2245
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2246
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2246
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2247
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2247
acuggcgccu uuaucaucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2248
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2248
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2249
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2249
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaag                                 96


<210>  2250
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2250
acuggcacuu uuaccugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2251
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2251
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2252
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2252
acuggcccuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2253
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2253
acuggcgcuu uuaccugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2254
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2254
acuggcgcuu uuaucugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2255
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2255
acuggcaccu uuaccugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2256
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2256
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2257
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2257
acuggccccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2258
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2258
acuggcgccu uuaucugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2259
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2259
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2260
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2260
gacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2261
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2261
acuggcgccu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2262
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2262
acuggcgcau uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2263
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2263
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2264
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2264
acuggcgcuu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2265
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2265
acuggcgcau uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2266
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2266
acuggcgcuu uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2267
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2267
acuggcgcuu uuauucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2268
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2268
acggcgcuuu uaucugauua cuuugagagc caucaccagc gacuaugucg uaguggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2269
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2269
acuggcgcuu uuauaugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2270
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2270
acuggcgcuu uuaucuugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2271
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2271
acuggcgcuu uuaucugauu acuuugagag ccagcaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2272
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2272
acuggcgcug uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2273
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2273
acuggcgcuc uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2274
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2274
acuggcgcuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2275
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2275
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2276
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2276
acuggcgcuu ugaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2277
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2277
acuggcgcuu ucaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2278
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2278
acuggcgcug uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2279
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2279
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2280
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2280
acuggcgcuu uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2281
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2281
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  2282
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2282
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2283
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2283
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucaaag                               98


<210>  2284
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2284
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  2285
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2285
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2286
cuaccaccac caccaccauc                                                   20


<210>  2287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2287
ccaccaccac cauuaccacc                                                   20


<210>  2288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2288
ccaccaucac caccaccacc                                                   20


<210>  2289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2289
ucaccaccau caccaccacc                                                   20


<210>  2290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2290
ccaucaucac caccaucacc                                                   20


<210>  2291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2291
ccaccaguac caucaccauc                                                   20


<210>  2292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2292
ccaucaccac caguaccauc                                                   20


<210>  2293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2293
ccaccaccac caccaucacc                                                   20


<210>  2294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2294
ccaccaguac caucaccacc                                                   20


<210>  2295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2295
ccaccaguac caucaccacc                                                   20


<210>  2296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2296
cuaccaccac caccaucacc                                                   20


<210>  2297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2297
ccaccaccac cauuaccacc                                                   20


<210>  2298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2298
acaccaccau cuccaccacc                                                   20


<210>  2299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2299
ccaucaacac caccaucucc                                                   20


<210>  2300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2300
ccaccaguac caucaccauc                                                   20


<210>  2301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2301
ccaccaguac caucaccacc                                                   20


<210>  2302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2302
ccaucaccac caguaccauc                                                   20


<210>  2303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2303
ccaccaccac caccaucacc                                                   20


<210>  2304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2304
ccaccaguag caucaccacc                                                   20


<210>  2305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2305
ccaccaguac caucaccacc                                                   20


<210>  2306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2306
cuaccaccac caccaucacc                                                   20


<210>  2307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2307
cuaccaccac caccaccacc                                                   20


<210>  2308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2308
ccaccaccac caucacuacc                                                   20


<210>  2309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2309
ccaccaguac caucaccacc                                                   20


<210>  2310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2310
cuaccaccac caccaucacc                                                   20


<210>  2311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2311
ccaccaccac cauuaccacc                                                   20


<210>  2312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2312
ccaccacuac caccaccacc                                                   20


<210>  2313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2313
ccaccaucac caccacuacc                                                   20


<210>  2314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2314
ccaccaguac caucaccacc                                                   20


<210>  2315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2315
cuaccaccac caccaucacc                                                   20


<210>  2316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2316
ccaccaccac cacaaccacc                                                   20


<210>  2317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2317
ccaccaccac cacaaccacc                                                   20


<210>  2318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2318
ccaccaccac caccaccauc                                                   20


<210>  2319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2319
uuguaguuaa aaugugaagg                                                   20


<210>  2320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2320
aaaggaguca guuuaggguu                                                   20


<210>  2321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2321
uuagccaagg ccagaaucaa                                                   20


<210>  2322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2322
ucaaucacua gccacggagc                                                   20


<210>  2323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2323
cuagccacgg agcaagacaa                                                   20


<210>  2324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2324
cugugggucu ucuccccagg                                                   20


<210>  2325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2325
gcucccagcc uccagugagg                                                   20


<210>  2326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2326
auuuuggaag uaacuccuuc                                                   20


<210>  2327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2327
cuauacacau ggacauuugu                                                   20


<210>  2328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2328
caggcguggg gauuagagcu                                                   20


<210>  2329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2329
ccacgccugg gaugagugca                                                   20


<210>  2330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2330
gugaaagaaa cccaaaauca                                                   20


<210>  2331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2331
agcacuacag cuacaaacaa                                                   20


<210>  2332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2332
uaaaccacag gauaucacau                                                   20


<210>  2333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2333
ugugguuuau gaugcacguu                                                   20


<210>  2334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2334
cauuucaauu ccauuaaaau                                                   20


<210>  2335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2335
auuuuaaugg aauugaaaug                                                   20


<210>  2336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2336
uuacaacagc cuugcagaua                                                   20


<210>  2337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2337
gcaaggcugu uguaaugaug                                                   20


<210>  2338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2338
aacaacaaca aauaaauaag                                                   20


<210>  2339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2339
ucuuuccaca agacaauaau                                                   20


<210>  2340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2340
ccccauguuu ccaggcuacc                                                   20


<210>  2341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2341
gcaaggcugg uuuacaugca                                                   20


<210>  2342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2342
gcauuuugcu uuuugcuugg                                                   20


<210>  2343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2343
acucauuucc uaucagcauu                                                   20


<210>  2344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2344
uuuuuuaugg gacagagucc                                                   20


<210>  2345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2345
uaaauauagc augggaagag                                                   20


<210>  2346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2346
cugaaggcgc uaucauaaau                                                   20


<210>  2347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2347
ugucaacugg aaaccuuaca                                                   20


<210>  2348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2348
guguaagguu uccaguugac                                                   20


<210>  2349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2349
uccauugcuu uguauuguga                                                   20


<210>  2350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2350
uuaucuucca uugcuuugua                                                   20


<210>  2351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2351
ucaccauuuu acugcacuuu                                                   20


<210>  2352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2352
aauagucaau gaaacauuug                                                   20


<210>  2353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2353
cagugcuaca aauguuucau                                                   20


<210>  2354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2354
ggggauuuua cgguuuaugu                                                   20


<210>  2355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2355
ccagauugca caaaccaaau                                                   20


<210>  2356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2356
ugagacagac uggaggauag                                                   20


<210>  2357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2357
uccagucugu cucaagaugg                                                   20


<210>  2358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2358
auccuccagu cugucucaag                                                   20


<210>  2359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2359
ugaacuccaa accucuagaa                                                   20


<210>  2360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2360
ucaugaacuc caaaccucua                                                   20


<210>  2361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2361
aagucuguuu uucuugucuc                                                   20


<210>  2362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2362
uagaguacaa caacaacacu                                                   20


<210>  2363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2363
uguucuccuu auauagagca                                                   20


<210>  2364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2364
ugucccaacu gccuuggcug                                                   20


<210>  2365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2365
uuacccacca ggcuccuugc                                                   20


<210>  2366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2366
acagagacau uucauccucu                                                   20


<210>  2367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2367
ucucugaccc aaaacaaaau                                                   20


<210>  2368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2368
guaguaauuu uacgccacac                                                   20


<210>  2369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2369
gagaauccau cuuugcacuu                                                   20


<210>  2370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2370
aucuuugcac uuguuuuugc                                                   20


<210>  2371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2371
uugcacuugu uuuugccuca                                                   20


<210>  2372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2372
uuuucuuagg aaacacaggc                                                   20


<210>  2373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2373
cugugauccc agcauaaacg                                                   20


<210>  2374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2374
cagagauacc uggguugccu                                                   20


<210>  2375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2375
cagcauaaac gcaacaggua                                                   20


<210>  2376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2376
aaguaccugu ugcguuuaug                                                   20


<210>  2377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2377
uuguaugggg aguaucaaau                                                   20


<210>  2378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2378
aauuucaaau ucucugccac                                                   20


<210>  2379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2379
augccuagcc ccucgcauga                                                   20


<210>  2380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2380
cuuguuggca aacuugucua                                                   20


<210>  2381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2381
gguccugccg ucagcuuguu                                                   20


<210>  2382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2382
cuacaguguc uggccgugug                                                   20


<210>  2383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2383
gacuaucugg cagcauaguu                                                   20


<210>  2384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2384
ggcagcauag uuuguuuuug                                                   20


<210>  2385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2385
ucaagucugu cccuucauuu                                                   20


<210>  2386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2386
agucuguccc uucauuuuac                                                   20


<210>  2387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2387
guaaaaugaa gggacagacu                                                   20


<210>  2388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2388
guguagccau gggcaaguca                                                   20


<210>  2389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2389
ucaguguagc caugggcaag                                                   20


<210>  2390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2390
ucacauugug guuaaucauc                                                   20


<210>  2391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2391
ccugacuccu gauccagugg                                                   20


<210>  2392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2392
ggagucagga gauuaauucu                                                   20


<210>  2393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2393
aguggucuuu ccugggaauu                                                   20


<210>  2394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2394
guagaaacag gaccuucuug                                                   20


<210>  2395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2395
auuaagcagu acuuaaccgu                                                   20


<210>  2396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2396
gccuaagaag cuauuuacuu                                                   20


<210>  2397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2397
uccuucagga agagggucaa                                                   20


<210>  2398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2398
gcuggggucc ccaguuggcu                                                   20


<210>  2399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2399
auaauauucu cuuugguaag                                                   20


<210>  2400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2400
acauucccac augaacugga                                                   20


<210>  2401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2401
uagcaagaag uuaagcccua                                                   20


<210>  2402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2402
cggcuuaggc aaaguaaagu                                                   20


<210>  2403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2403
caauuaaugc uucugagcgu                                                   20


<210>  2404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2404
cuggcugggg agaaugaaag                                                   20


<210>  2405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2405
cccacuuccu agccagcaac                                                   20


<210>  2406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2406
aguuaugucc ucuuuuuuuc                                                   20


<210>  2407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2407
cuugccuaag agcacuaaca                                                   20


<210>  2408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2408
ggggugggcc ugggucugcg                                                   20


<210>  2409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2409
gcaucaccug ggaguuuguu                                                   20


<210>  2410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2410
ccugggaguu uguucaaaau                                                   20


<210>  2411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2411
gaaauugagg guggggaagc                                                   20


<210>  2412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2412
ccuggagaau uuauucaaca                                                   20


<210>  2413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2413
gcacugcugu cuuaggguaa                                                   20


<210>  2414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2414
cuaaggaucc cuccauuagg                                                   20


<210>  2415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2415
uuagggauuc ccuaagcuua                                                   20


<210>  2416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2416
cuccauuagg aaauucaggu                                                   20


<210>  2417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2417
augacagacg gaggguggaa                                                   20


<210>  2418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2418
gguccagggc cuucuuagca                                                   20


<210>  2419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2419
gucuggcaca agcugguuug                                                   20


<210>  2420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2420
uuuuucaaau gucuuacacu                                                   20


<210>  2421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2421
aagccauucc caguuugcug                                                   20


<210>  2422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2422
cacugggcuu agagcucuuu                                                   20


<210>  2423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2423
aguuuuuugg uuuccucaag                                                   20


<210>  2424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2424
caaagauucc uugacuauua                                                   20


<210>  2425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2425
uugagauguu cuugaggaaa                                                   20


<210>  2426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2426
cugggugugu aauacagcca                                                   20


<210>  2427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2427
acagguaaua cugcagauuu                                                   20


<210>  2428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2428
gcaguauuac cuguugauua                                                   20


<210>  2429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2429
uuccaacacg uuuaaugacu                                                   20


<210>  2430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2430
auguacuccu guggagaguc                                                   20


<210>  2431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2431
aaaaacauau guuuaggaaa                                                   20


<210>  2432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2432
cgugacacug ugacccccuu                                                   20


<210>  2433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2433
auucucuuuu ugaagaccca                                                   20


<210>  2434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2434
uagugucauc cauucucuuu                                                   20


<210>  2435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2435
ucaagucccu cagcucuucc                                                   20


<210>  2436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2436
ugaacguuug uaaaguaccc                                                   20


<210>  2437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2437
gauuacuagg uucaagccac                                                   20


<210>  2438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2438
gauucagaac uggaaugggu                                                   20


<210>  2439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2439
agcucuugac ccuauguuua                                                   20


<210>  2440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2440
augguaaaca uagggucaag                                                   20


<210>  2441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2441
aagugagaag aacugguauc                                                   20


<210>  2442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2442
gaguauuaua gagcaaacau                                                   20


<210>  2443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2443
guaaugaaaa ugugccagcu                                                   20


<210>  2444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2444
ucacucacag acuucuuaau                                                   20


<210>  2445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2445
cucacagacu ucuuaauuaa                                                   20


<210>  2446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2446
gaagguuaau uaagaagucu                                                   20


<210>  2447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2447
cacucucuuu uguucuagaa                                                   20


<210>  2448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2448
ugauguucuu uaaaaagugu                                                   20


<210>  2449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2449
ggauuuggua aaacagccag                                                   20


<210>  2450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2450
aaggaccaug agagaguuuc                                                   20


<210>  2451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2451
aggaaucuaa ggaccaugag                                                   20


<210>  2452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2452
aucacucauu uuaaaacucu                                                   20


<210>  2453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2453
cucauuuuaa aacucuuuuu                                                   20


<210>  2454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2454
aaaaagaguu uuaaaaugag                                                   20


<210>  2455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2455
augcuauccu cuuagagccu                                                   20


<210>  2456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2456
ucuuagagcc uugauuacuc                                                   20


<210>  2457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2457
aggcucuaag aggauagcau                                                   20


<210>  2458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2458
cuacuuccuc ccuuuauuga                                                   20


<210>  2459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2459
auaaaaaugc cagccaccaa                                                   20


<210>  2460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2460
gucaggccua aacaaaauuu                                                   20


<210>  2461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2461
ugcuuuucug aaaagcaacu                                                   20


<210>  2462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2462
uuguguugaa augcagauuu                                                   20


<210>  2463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2463
gcauuucaac acaaagaugg                                                   20


<210>  2464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2464
uucauuucaa aagguugaau                                                   20


<210>  2465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2465
uauucaaccu uuugaaauga                                                   20


<210>  2466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2466
agugaaaaua cuuugggccc                                                   20


<210>  2467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2467
ugaauuagau aaauuuuuau                                                   20


<210>  2468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2468
aauucacgau caagugaaaa                                                   20


<210>  2469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2469
aggagacuga gagggcagcu                                                   20


<210>  2470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2470
cauaccucac uaugcaaaau                                                   20


<210>  2471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2471
ugggaacaca cauuuugcau                                                   20


<210>  2472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2472
guguccgugu uuucuuugua                                                   20


<210>  2473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2473
guaccucucu caugacacac                                                   20


<210>  2474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2474
uuucucuugg cucuccaggu                                                   20


<210>  2475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2475
uagauaaaaa gaaaaagcag                                                   20


<210>  2476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2476
aggauauccu uucucuuggc                                                   20


<210>  2477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2477
uuaccugcuu uuucuuuuua                                                   20


<210>  2478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2478
aaauauugca cacugauuca                                                   20


<210>  2479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2479
gugugcaaua uuuugaugug                                                   20


<210>  2480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2480
aguugacagc ggaggauacg                                                   20


<210>  2481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2481
uccgcuguca acuggaugaa                                                   20


<210>  2482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2482
aaauaaaucc ucugaagauu                                                   20


<210>  2483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2483
ucugaagauu ucugugacau                                                   20


<210>  2484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2484
ucagaggauu uauuuagaug                                                   20


<210>  2485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2485
ucagcuuuca caagugcgua                                                   20


<210>  2486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2486
guucuguuuu ccccccaccu                                                   20


<210>  2487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2487
acacuuguuu gucugacuca                                                   20


<210>  2488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2488
auuucagaug ucucauugcc                                                   20


<210>  2489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2489
gaaauagauu auuuaagcca                                                   20


<210>  2490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2490
uaaacuggca augagacauc                                                   20


<210>  2491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2491
caauguuucu ugcacaguca                                                   20


<210>  2492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2492
ucaacuugac caucccucca                                                   20


<210>  2493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2493
acuugaccau cccuccaaau                                                   20


<210>  2494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2494
cuccaaauuu ccccucuuuc                                                   20


<210>  2495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2495
uccccauggc uuugaaaaga                                                   20


<210>  2496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2496
ucagcugagg acucagagca                                                   20


<210>  2497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2497
uguuugugug uagugggggc                                                   20


<210>  2498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2498
gagguauuua ucagguuauu                                                   20


<210>  2499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2499
gguuauuugg gagcuacuuu                                                   20


<210>  2500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2500
cugaaaguag cucccaaaua                                                   20


<210>  2501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2501
ggggaguggu ggcaguggga                                                   20


<210>  2502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2502
uuucuuucug gcccuaagug                                                   20


<210>  2503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2503
uuaaaaggag aagacuggau                                                   20


<210>  2504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2504
agucuucucc uuuuaaagau                                                   20


<210>  2505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2505
aauccagucu ucuccuuuua                                                   20


<210>  2506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2506
uggccagcuu cuagcacggc                                                   20


<210>  2507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2507
aggucaaggu caugagggga                                                   20


<210>  2508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2508
uuaggcuuag agagugagcc                                                   20


<210>  2509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2509
ggcucacucu cuaagccuaa                                                   20


<210>  2510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2510
ucaggcucac ucucuaagcc                                                   20


<210>  2511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2511
aucaucaggc ucacucucua                                                   20


<210>  2512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2512
gcauggaggg uucuuggaaa                                                   20


<210>  2513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2513
uauuugcuaa ccaacauaau                                                   20


<210>  2514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2514
cugaaauuau guugguuagc                                                   20


<210>  2515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2515
ucucugucaa guaguuaaug                                                   20


<210>  2516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2516
uuaacuacuu gacagagagg                                                   20


<210>  2517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2517
guaaacaaac acuuuaaauu                                                   20


<210>  2518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2518
uucuguaaug ugaaaaauca                                                   20


<210>  2519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2519
cucucuaauu uaucaguuuc                                                   20


<210>  2520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2520
guuuccauua augagauuuu                                                   20


<210>  2521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2521
cauuaaugga aacugauaaa                                                   20


<210>  2522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2522
augccuuugu aguuagaagg                                                   20


<210>  2523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2523
ucccuucuaa cuacaaaggc                                                   20


<210>  2524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2524
caaacacccc gaugccuccc                                                   20


<210>  2525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2525
ggguguuugu gauacguuug                                                   20


<210>  2526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2526
uuuucuucau uucucgagug                                                   20


<210>  2527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2527
ucauuuggac accuggaaag                                                   20


<210>  2528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2528
uuuggacacc uggaaagccu                                                   20


<210>  2529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2529
aauacuuaac cugggagaaa                                                   20


<210>  2530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2530
ucacagcccc augccucuuc                                                   20


<210>  2531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2531
aucuucacag ccccaugccu                                                   20


<210>  2532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2532
cauccaucuu cacagcccca                                                   20


<210>  2533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2533
uucucaucgc auccaucuuc                                                   20


<210>  2534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2534
uuugcaaacg uuugauucug                                                   20


<210>  2535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2535
aacguuugca aaugaucauu                                                   20


<210>  2536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2536
gaaucaaacg uuugcaaaug                                                   20


<210>  2537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2537
aagccagcag aacacacaac                                                   20


<210>  2538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2538
gcaucaacuc acaacaaaug                                                   20


<210>  2539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2539
acucacaaca aaugugcuuu                                                   20


<210>  2540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2540
uuucgaucgg ucuugagaaa                                                   20


<210>  2541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2541
aaaugauaau auagaggcau                                                   20


<210>  2542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2542
gucuugagaa aauacuagaa                                                   20


<210>  2543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2543
cuccccuugc cccuccaccc                                                   20


<210>  2544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2544
acauuaggca uuucuccuaa                                                   20


<210>  2545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2545
ucuacauuag gcauuucucc                                                   20


<210>  2546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2546
acccaucauc uacauuaggc                                                   20


<210>  2547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2547
cagaacuuag aguaaaauaa                                                   20


<210>  2548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2548
aacauggugu uuccaagaga                                                   20


<210>  2549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2549
ggagucucuu ggaaacacca                                                   20


<210>  2550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2550
uccaagacug gucugugcac                                                   20


<210>  2551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2551
aagacugguc ugugcacgga                                                   20


<210>  2552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2552
guccuggccu uuauggaaag                                                   20


<210>  2553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2553
uggcucacug caaccuccgc                                                   20


<210>  2554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2554
cuacaaaaaa uacaaaaauu                                                   20


<210>  2555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2555
caucucuaca aaaaauacaa                                                   20


<210>  2556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2556
caccauguug cccaggcugg                                                   20


<210>  2557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2557
ugccccaaca gucgcccugu                                                   20


<210>  2558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2558
ucgaguuccu cacugggagg                                                   20


<210>  2559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2559
cagaaguguc cugcugugga                                                   20


<210>  2560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2560
ccucacuugc cuuucuggca                                                   20


<210>  2561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2561
cuuggccaag acugucacag                                                   20


<210>  2562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2562
cucuggcaaa gucccacaga                                                   20


<210>  2563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2563
uucauuuaua ccacugacca                                                   20


<210>  2564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2564
ggaaagaguu cccugagcaa                                                   20


<210>  2565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2565
ccaauuugcu cagggaacuc                                                   20


<210>  2566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2566
gcgggcaucu ccaauuugcu                                                   20


<210>  2567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2567
uuggagcagc cucaguccag                                                   20


<210>  2568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2568
gcagaauuag uagagccaag                                                   20


<210>  2569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2569
aauguuccca gacaccucca                                                   20


<210>  2570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2570
ucaacuccuu ucuacccacc                                                   20


<210>  2571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2571
uuuugcuucc agggccucaa                                                   20


<210>  2572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2572
gugggccggu gacagagggg                                                   20


<210>  2573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2573
cagcugccau cgcacucaaa                                                   20


<210>  2574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2574
cacucaaacc cugucaggcg                                                   20


<210>  2575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2575
auguaauuca aggcaaagag                                                   20


<210>  2576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2576
gcgugggaca gguucuuuug                                                   20


<210>  2577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2577
aaagaaccug ucccacgcug                                                   20


<210>  2578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2578
gaaaaugaaa cgcuucuguc                                                   20


<210>  2579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2579
aaaaacgguu gguggaaggg                                                   20


<210>  2580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2580
gaaguugaca gguugggaca                                                   20


<210>  2581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2581
uacuuugcau uuauggccug                                                   20


<210>  2582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2582
caguggggcc uccucccggg                                                   20


<210>  2583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2583
uuuacaggcc uuuguguuac                                                   20


<210>  2584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2584
aggagaaaug gaguggagag                                                   20


<210>  2585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2585
aagucucccu guaaucagca                                                   20


<210>  2586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2586
gcauguaucu accacugguu                                                   20


<210>  2587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2587
accacugguu cuccaacuaa                                                   20


<210>  2588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2588
uaauuauuua uugaggggcu                                                   20


<210>  2589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2589
uuuacuaggg aagguuuccc                                                   20


<210>  2590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2590
ucuccugggu caaggcugac                                                   20


<210>  2591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2591
cuucacugua cuauuuuggc                                                   20


<210>  2592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2592
guaauagugu auuuacucaa                                                   20


<210>  2593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2593
gguuaaucau ucacuuucca                                                   20


<210>  2594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2594
uucacuuucc aaaugcugug                                                   20


<210>  2595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2595
gcuguagcuc uuuuaacugu                                                   20


<210>  2596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2596
uccacauuuu ccucuauucu                                                   20


<210>  2597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2597
ccuaccugca cccccaucuc                                                   20


<210>  2598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2598
cugucccaag agaaagaaca                                                   20


<210>  2599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2599
uauuuuugaa cucauaguuc                                                   20


<210>  2600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2600
gaggcaggga ggcagcuggg                                                   20


<210>  2601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2601
agugcaacuu gggugacaag                                                   20


<210>  2602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2602
ugguacagcc cagugguggc                                                   20


<210>  2603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2603
ccuugagcac agcagggcuu                                                   20


<210>  2604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2604
cauuccaggg cccuucccag                                                   20


<210>  2605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2605
ccuccccucc cagcacccca                                                   20


<210>  2606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2606
cugcuuggga caugcuggaa                                                   20


<210>  2607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2607
cugcuucauu uuuguuuuca                                                   20


<210>  2608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2608
uaggaaaagu aaaaacauuc                                                   20


<210>  2609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2609
cuguccuccu ucaccugcca                                                   20


<210>  2610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2610
aggugacagu gcuguccacg                                                   20


<210>  2611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2611
uucuuuuccc cacaugcucc                                                   20


<210>  2612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2612
cacuugugga aaaaaaaugc                                                   20


<210>  2613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2613
cacagaaugu acuaggguuc                                                   20


<210>  2614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2614
caguguccug gaaugagcuc                                                   20


<210>  2615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2615
guccaacccc uuucuuuuga                                                   20


<210>  2616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2616
aguucaucaa ggucacuucu                                                   20


<210>  2617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2617
aggucacuuc ugacucccag                                                   20


<210>  2618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2618
cucaugauuc uaucuugaga                                                   20


<210>  2619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2619
ugagagaugc aaaaugucca                                                   20


<210>  2620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2620
ugagaguuua guuugguugg                                                   20


<210>  2621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2621
gccuccuccc cacacaccuc                                                   20


<210>  2622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2622
ggaacuggag aaaagugaga                                                   20


<210>  2623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2623
ggauuuggca uuuaaaucca                                                   20


<210>  2624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2624
ugauuugugg caaaguuguc                                                   20


<210>  2625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2625
acaggaagca agaagaauag                                                   20


<210>  2626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2626
auaaauaagc agucccucua                                                   20


<210>  2627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2627
gcaaaucuau aaauaagcag                                                   20


<210>  2628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2628
cauucaucug caaaucuaua                                                   20


<210>  2629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2629
cccaacccug aaagcacacu                                                   20


<210>  2630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2630
caagguuaag aucagcuucc                                                   20


<210>  2631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2631
uaaccuuggg augcagugug                                                   20


<210>  2632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2632
gcuuccugaa aacagggcag                                                   20


<210>  2633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2633
aguuaaaugu agugugguac                                                   20


<210>  2634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2634
caugaacuga auccaguuaa                                                   20


<210>  2635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2635
ucucuuucug augacauuuu                                                   20


<210>  2636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2636
cuuucugaug acauuuuaaa                                                   20


<210>  2637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2637
gaaagagaug auuacacauu                                                   20


<210>  2638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2638
aacuagacaa auaauugcag                                                   20


<210>  2639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2639
auuauugcug caauuauuug                                                   20


<210>  2640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2640
uccagcuuga cucugcuauc                                                   20


<210>  2641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2641
uugauuggca gaguccccac                                                   20


<210>  2642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2642
augaucuucc agcuugacuc                                                   20


<210>  2643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2643
uucuuucaaa cauuacagaa                                                   20


<210>  2644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2644
uuucuguaau guuugaaaga                                                   20


<210>  2645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2645
ucauuucugu aauguuugaa                                                   20


<210>  2646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2646
gcaaaaguua gacuuaaaca                                                   20


<210>  2647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2647
gauuuacuga uaaaggcacu                                                   20


<210>  2648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2648
gauuuugagc auuuaucagc                                                   20


<210>  2649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2649
guaaaucaga uuuugagcau                                                   20


<210>  2650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2650
ugggcugaag ugcagguuuu                                                   20


<210>  2651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2651
cgcaaaguaa ucaugggcug                                                   20


<210>  2652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2652
ggcaguguga uuuauauuau                                                   20


<210>  2653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2653
cacugccuga uucuucucaa                                                   20


<210>  2654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2654
uugcaguuau ucaugggaaa                                                   20


<210>  2655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2655
acacaggcga gagaaguguu                                                   20


<210>  2656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2656
ggguuuacag ccguuuuccc                                                   20


<210>  2657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2657
cgugguagag aaauggucuu                                                   20


<210>  2658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2658
gcuccauuca ggccuuugaa                                                   20


<210>  2659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2659
augccucaaa uugggacuca                                                   20


<210>  2660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2660
auuuaaacca cuuuucaaag                                                   20


<210>  2661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2661
uugcacuggg caggggaauu                                                   20


<210>  2662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2662
cuggccaagg ucagaagacu                                                   20


<210>  2663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2663
gggacuugcc uggucucaag                                                   20


<210>  2664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2664
ucugggacuu gccuggucuc                                                   20


<210>  2665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2665
caggcaaguc cccagguaua                                                   20


<210>  2666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2666
acugcugucu augucaugug                                                   20


<210>  2667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2667
aaacacauga cauagacagc                                                   20


<210>  2668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2668
ucucuugagu uauuucugac                                                   20


<210>  2669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2669
aaugaaugag cuggcauauu                                                   20


<210>  2670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2670
acgucugcua auaugccagc                                                   20


<210>  2671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2671
aaaacagaag auguaucugg                                                   20


<210>  2672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2672
ucuguuuuag auuuuccuua                                                   20


<210>  2673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2673
ggaugcuuca gcagacaaca                                                   20


<210>  2674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2674
agauacaucu ucuguuuuag                                                   20


<210>  2675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2675
uccuucuagu gcuuugggcg                                                   20


<210>  2676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2676
gaagcuuguu agauguaaug                                                   20


<210>  2677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2677
aacaagcuuc ugauuuuuaa                                                   20


<210>  2678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2678
uuacaucuaa caagcuucug                                                   20


<210>  2679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2679
gcauugugac acuuaccgcg                                                   20


<210>  2680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2680
gagggcuuuc uaauuaacag                                                   20


<210>  2681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2681
acagcucaug cuuuugaugc                                                   20


<210>  2682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2682
aaagcaugag cugucgauag                                                   20


<210>  2683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2683
ggcuucuggg cuacagggaa                                                   20


<210>  2684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2684
gcacucacau ucagcugaaa                                                   20


<210>  2685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2685
ucuuucucau cuucucucuc                                                   20


<210>  2686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2686
ucucucucuu uaguccucaa                                                   20


<210>  2687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2687
guaaaaccua cuucccuuuc                                                   20


<210>  2688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2688
cugcuguuuc agugaaaagc                                                   20


<210>  2689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2689
ccauuccagu auaaaaccuc                                                   20


<210>  2690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2690
ccccagaccc ccagcacaua                                                   20


<210>  2691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2691
aguucaagcc aaaaagaaau                                                   20


<210>  2692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2692
ucuguggcac uuguuuagga                                                   20


<210>  2693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2693
aaauaggaaa uacaaaaaac                                                   20


<210>  2694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2694
cuugcagcca caauuucgca                                                   20


<210>  2695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2695
agaguguaau ggaagucugg                                                   20


<210>  2696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2696
cauugcauuu cauaagccag                                                   20


<210>  2697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2697
uuggcauucu ugcuggagug                                                   20


<210>  2698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2698
ucguucuugg cuagcagaug                                                   20


<210>  2699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2699
gcuagccaag aacgaagaug                                                   20


<210>  2700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2700
acucauuuaa aaagaaaaac                                                   20


<210>  2701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2701
aacgucacga agcugcugaa                                                   20


<210>  2702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2702
agguugcugg gacagcuucc                                                   20


<210>  2703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2703
ggugaagggc uacuucuggg                                                   20


<210>  2704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2704
aucuggugaa gggcuacuuc                                                   20


<210>  2705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2705
caucaccaga uagcucuugg                                                   20


<210>  2706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2706
ccagauagcu cuuggaaaua                                                   20


<210>  2707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2707
ggugauggga uccaucuggu                                                   20


<210>  2708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2708
gauucucauu uucaacaaga                                                   20


<210>  2709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2709
gaugcagcaa uguauuauuu                                                   20


<210>  2710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2710
cauuccucag ccuucuuguu                                                   20


<210>  2711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2711
uuuuaguaug uuuagggauc                                                   20


<210>  2712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2712
cuaaacauac uaaaaagauu                                                   20


<210>  2713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2713
auuuccauau cuacccaaaa                                                   20


<210>  2714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2714
acccaaaauc uccaagcccc                                                   20


<210>  2715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2715
ccaagccccu uguucuauca                                                   20


<210>  2716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2716
gcaggucaag aguagagaac                                                   20


<210>  2717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2717
auuucagaau ggagaacagc                                                   20


<210>  2718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2718
uagggagacu gguacugggg                                                   20


<210>  2719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2719
ccaguaccag ucucccuagg                                                   20


<210>  2720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2720
caagucauuc ucuggaaagg                                                   20


<210>  2721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2721
aagugagaca ccaaucacag                                                   20


<210>  2722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2722
cagcucuacu ggcccaccuu                                                   20


<210>  2723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2723
guucuuucuc auugugugag                                                   20


<210>  2724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2724
cucaaaaugu gugugugugu                                                   20


<210>  2725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2725
aagauacuga aagaaaaugg                                                   20


<210>  2726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2726
uagauuggua ggucuuuaga                                                   20


<210>  2727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2727
ggcccagaaa agccuugaaa                                                   20


<210>  2728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2728
acagaccaca gcccugugau                                                   20


<210>  2729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2729
cagggcugug gucuguggau                                                   20


<210>  2730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2730
cauguccauc acagggcugu                                                   20


<210>  2731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2731
ucuggcuuug agaugaauaa                                                   20


<210>  2732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2732
caaagccaga ggaucucaug                                                   20


<210>  2733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2733
ugcugcucau uucugugcau                                                   20


<210>  2734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2734
aucaugcugc ucauuucugu                                                   20


<210>  2735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2735
gccagcuaau ccaucaugcu                                                   20


<210>  2736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2736
ggauugggcc ugaaacuucu                                                   20


<210>  2737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2737
ugauguugag uuggcauguu                                                   20


<210>  2738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2738
aggccuuccu gagagaaguu                                                   20


<210>  2739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2739
aaugcuauca aggccuuccu                                                   20


<210>  2740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2740
cuucccaggg agacguuccc                                                   20


<210>  2741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2741
cucugucucu caaaccuggc                                                   20


<210>  2742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2742
gaacaaauua auauuuaauu                                                   20


<210>  2743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2743
uaaaauuaaa uauuaauuug                                                   20


<210>  2744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2744
gaauaaaaaa gacucgggag                                                   20


<210>  2745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2745
cccgagucuu uuuuauucug                                                   20


<210>  2746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2746
cagguuggag gcagggaaac                                                   20


<210>  2747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2747
uuccccuucc ugccuugugg                                                   20


<210>  2748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2748
uuacaugggu aaaagguuag                                                   20


<210>  2749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2749
aguuaaugua auauuuugcc                                                   20


<210>  2750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2750
augaaagagu aagauaauuu                                                   20


<210>  2751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2751
uacucuuuca uugauuaaag                                                   20


<210>  2752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2752
aauuaucuua cucuuucauu                                                   20


<210>  2753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2753
uauaaaacuc ccuaaccuau                                                   20


<210>  2754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2754
acuugcaaaa uauagguuag                                                   20


<210>  2755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2755
ccagucaggc uuucaggugu                                                   20


<210>  2756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2756
guauggaaau ugggaaaucg                                                   20


<210>  2757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2757
ucuucucaaa uguagauuau                                                   20


<210>  2758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2758
acauuugaga agacgauuuc                                                   20


<210>  2759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2759
ucccuuggga uccuucugga                                                   20


<210>  2760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2760
caagggaaga uaaucuacau                                                   20


<210>  2761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2761
uucuggaggg cuauaaauaa                                                   20


<210>  2762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2762
acauuagaua uuuaaaaaug                                                   20


<210>  2763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2763
aauguugauu aguauguucu                                                   20


<210>  2764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2764
guauucauuu uuaaauaucu                                                   20


<210>  2765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2765
gaaucuguau ucauuuuuaa                                                   20


<210>  2766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2766
uuuaguuuuc ccuuaaucug                                                   20


<210>  2767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2767
agaacaaaac aaaacaaaaa                                                   20


<210>  2768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2768
gcuaagccuu cuuuuucaug                                                   20


<210>  2769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2769
cccuuaaguu agcccuauuc                                                   20


<210>  2770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2770
accauucuau cuaaggaagc                                                   20


<210>  2771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2771
aaggaagcug cagaaaggug                                                   20


<210>  2772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2772
ggauaagaau uuggucuaaa                                                   20


<210>  2773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2773
agauuuccca uuaaagguuc                                                   20


<210>  2774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2774
gggagcugga guuggaguac                                                   20


<210>  2775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2775
gccacuaaag guuuacugac                                                   20


<210>  2776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2776
aaaccugggg aagcaauaua                                                   20


<210>  2777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2777
aauuguucau auauugcuuc                                                   20


<210>  2778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2778
auaagcauuu aauaucuaau                                                   20


<210>  2779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2779
cucucugugc uauuacuuuu                                                   20


<210>  2780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2780
uggaagaguu ugucucacgg                                                   20


<210>  2781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2781
gacuauuuca ucaaagccug                                                   20


<210>  2782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2782
aagccuguaa aagauaccug                                                   20


<210>  2783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2783
uuuacaggcu uugaugaaau                                                   20


<210>  2784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2784
ugacucaggu aucuuuuaca                                                   20


<210>  2785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2785
aguuacaauu ugacagcauu                                                   20


<210>  2786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2786
uuaaaugcug ucaaauugua                                                   20


<210>  2787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2787
caaguacugu caucuuuaaa                                                   20


<210>  2788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2788
uguuauggca uuguccuauu                                                   20


<210>  2789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2789
augaucaguu uuuguuucau                                                   20


<210>  2790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2790
uagaugacau uaccuaaaug                                                   20


<210>  2791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2791
guuuuuguuu cauuuuuugc                                                   20


<210>  2792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2792
guaucaauag ccaaagaucc                                                   20


<210>  2793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2793
auagccaaag auccaaaaac                                                   20


<210>  2794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2794
uuggcuauug auacugauuu                                                   20


<210>  2795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2795
aaaaacagcc uaaagccacu                                                   20


<210>  2796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2796
uuuuggguag caguggcuuu                                                   20


<210>  2797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2797
cggcucaccg caaucuccgc                                                   20


<210>  2798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2798
ccgccucccg gguucaagcg                                                   20


<210>  2799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2799
cuugaacccg ggaggcggag                                                   20


<210>  2800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2800
cagcuacuug ggaggcugag                                                   20


<210>  2801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2801
ccuaaggucg ggaguuugag                                                   20


<210>  2802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2802
acccaccuca gccucccaaa                                                   20


<210>  2803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2803
cagcacuuug ggaggcugag                                                   20


<210>  2804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2804
ucaaagaaaa aaaaugcugu                                                   20


<210>  2805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2805
aaauucauac aauagaggca                                                   20


<210>  2806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2806
uccaggauga caaacagcca                                                   20


<210>  2807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2807
aggaugacaa acagccacac                                                   20


<210>  2808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2808
uggaugauga ggcagcuauu                                                   20


<210>  2809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2809
caaaagaaaa uucugaguag                                                   20


<210>  2810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2810
cugcuuuccu uguucccugg                                                   20


<210>  2811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2811
ccugagcccc cgggccguuc                                                   20


<210>  2812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2812
gccccccucu caccccaucc                                                   20


<210>  2813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2813
aaaaauguuu acucaaguuc                                                   20


<210>  2814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2814
cucuuuaaua guguccuccu                                                   20


<210>  2815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2815
cagggauaug aauuuugaug                                                   20


<210>  2816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2816
cugugaucuc ucuuuaauag                                                   20


<210>  2817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2817
aaauucauau cccugugauc                                                   20


<210>  2818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2818
ucaaaaugau aaaugcuauc                                                   20


<210>  2819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2819
aaaugauaaa ugcuaucaug                                                   20


<210>  2820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2820
uuuugaugau augugacaaa                                                   20


<210>  2821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2821
ugaaacacca uccaugcccu                                                   20


<210>  2822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2822
augcccugag uaucccaaca                                                   20


<210>  2823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2823
caacauggau ggacuggagg                                                   20


<210>  2824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2824
auguugggau acucagggca                                                   20


<210>  2825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2825
gggucuguau uggucccuug                                                   20


<210>  2826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2826
agggcccauc agggucugua                                                   20


<210>  2827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2827
gcaauggggg caaaggcaaa                                                   20


<210>  2828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2828
uggaaagcuu uccuuuugcc                                                   20


<210>  2829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2829
gguuccauuc ugcuagugaa                                                   20


<210>  2830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2830
ucuagaacau auaagucaac                                                   20


<210>  2831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2831
acccccuuug cagaguccuc                                                   20


<210>  2832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2832
ccuagcaugc ugccuuuguc                                                   20


<210>  2833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2833
gaagacaaag gcagcaugcu                                                   20


<210>  2834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2834
gaguauuuca gcagcccucu                                                   20


<210>  2835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2835
cagagggcug cugaaauacu                                                   20


<210>  2836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2836
auaggauaug guccaacucc                                                   20


<210>  2837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2837
uauagaucac agagggcugc                                                   20


<210>  2838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2838
uuccagagcu ccacaaucca                                                   20


<210>  2839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2839
aacuccaauu uucuauucca                                                   20


<210>  2840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2840
aggaaaauau ucugcccaag                                                   20


<210>  2841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2841
cuuccguucu cauuuccuuc                                                   20


<210>  2842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2842
ugcucauacu ucaaggccuc                                                   20


<210>  2843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2843
aucucauccu ucuccaaccu                                                   20


<210>  2844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2844
cauccuucuc caaccucaua                                                   20


<210>  2845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2845
uucuccaacc ucauagaaca                                                   20


<210>  2846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2846
caugcaccac ucccugacuc                                                   20


<210>  2847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2847
aggccuuaca uugcugguua                                                   20


<210>  2848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2848
ugucacaugc ugugcuggua                                                   20


<210>  2849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2849
gucauuuaua ugcuauuugu                                                   20


<210>  2850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2850
uuucuguuca aaaugguaau                                                   20


<210>  2851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2851
gaagggaaau guuugugggu                                                   20


<210>  2852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2852
acuugaacuu ucagauaaaa                                                   20


<210>  2853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2853
gaaaguucaa guagauauca                                                   20


<210>  2854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2854
uuguguagca uaacauguua                                                   20


<210>  2855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2855
acccucuuua aacagccacc                                                   20


<210>  2856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2856
ucuauaugug aagcccaacu                                                   20


<210>  2857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2857
gcaaagaagu uagucucagc                                                   20


<210>  2858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2858
ucaaugcaaa aagcuaaguu                                                   20


<210>  2859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2859
aaaugagguc cuuuuuagua                                                   20


<210>  2860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2860
uuugaaaugc ucccggccag                                                   20


<210>  2861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2861
cagcacuuug ggaggccggg                                                   20


<210>  2862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2862
uccugccccg gccucccaaa                                                   20


<210>  2863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2863
ccugagguca ggaguucaag                                                   20


<210>  2864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2864
ugaacuccug accucaggug                                                   20


<210>  2865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2865
guuuggacaa cacagugaaa                                                   20


<210>  2866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2866
cagcuacucg ggaggcugag                                                   20


<210>  2867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2867
ccugccucag ccucccgagu                                                   20


<210>  2868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2868
cuugaaccug ggaggcagaa                                                   20


<210>  2869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2869
ucugccuccc agguucaagc                                                   20


<210>  2870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2870
cggcucacug caucuucugc                                                   20


<210>  2871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2871
cgccauugca uuccagcccg                                                   20


<210>  2872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2872
ccgucucacc aaaaaaagaa                                                   20


<210>  2873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2873
ucacuccgug uugagagcca                                                   20


<210>  2874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2874
cuccguguug agagccaagu                                                   20


<210>  2875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2875
auacaguccu uagcacccaa                                                   20


<210>  2876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2876
gccaaauaaa ugaaguucag                                                   20


<210>  2877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2877
gaacuucauu uauuuggcag                                                   20


<210>  2878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2878
ggagaggaag auggauguag                                                   20


<210>  2879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2879
uccucuccag auucccucuc                                                   20


<210>  2880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2880
aucuuccucu ccagauuccc                                                   20


<210>  2881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2881
ccugugcuga auuccuguaa                                                   20


<210>  2882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2882
ccgcuuaagg agaagacaua                                                   20


<210>  2883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2883
guaugucuuc uccuuaagcg                                                   20


<210>  2884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2884
cagcacuuug ggaggucaag                                                   20


<210>  2885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2885
uccugccuug accucccaaa                                                   20


<210>  2886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2886
cuggagccca ggaguucaag                                                   20


<210>  2887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2887
cuacaaaauu agccaggcau                                                   20


<210>  2888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2888
ugucaccuca gccuccugag                                                   20


<210>  2889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2889
ccuaggcuca agccauccug                                                   20


<210>  2890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2890
aggcugcagu gagcuaugaa                                                   20


<210>  2891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2891
guuuuccuag aauuccagca                                                   20


<210>  2892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2892
accauaagca gagcauuugg                                                   20


<210>  2893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2893
cagugggccu cccucucucu                                                   20


<210>  2894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2894
cagaauacaa agggcauucu                                                   20


<210>  2895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2895
aacuguacac uuaaaaugaa                                                   20


<210>  2896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2896
agauacagaa cacguccacc                                                   20


<210>  2897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2897
ugauuuuggu ggaggccaca                                                   20


<210>  2898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2898
ccuucccuaa cccucugacc                                                   20


<210>  2899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2899
uguaugaguc cauuuguaac                                                   20


<210>  2900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2900
ucuuuugugu uuaauuucuu                                                   20


<210>  2901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2901
uucugcucug uggaagaaau                                                   20


<210>  2902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2902
cagaaucauu cugcucugug                                                   20


<210>  2903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2903
auggugugga guguguuacu                                                   20


<210>  2904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2904
auucaaccua uugguugcca                                                   20


<210>  2905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2905
acacaguguc cauuguagca                                                   20


<210>  2906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2906
aaggcauuuc gagaacacag                                                   20


<210>  2907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2907
uccaggcugc cccccuccca                                                   20


<210>  2908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2908
cagcuaucug uuuggcucag                                                   20


<210>  2909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2909
guuuggcuca gcuaccaaau                                                   20


<210>  2910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2910
uauuccgaau agaaaccucu                                                   20


<210>  2911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2911
uuuccuuagu guaguggaga                                                   20


<210>  2912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2912
ggccaaauaa auuggacucu                                                   20


<210>  2913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2913
cugacccaga guccaauuua                                                   20


<210>  2914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2914
ccuugacucu ccaugcugcu                                                   20


<210>  2915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2915
aggucucaca caacacucca                                                   20


<210>  2916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2916
uaauuuccug cacugaagcu                                                   20


<210>  2917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2917
ucaucagcuu ggccauggca                                                   20


<210>  2918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2918
gcuuggccau ggcagggcug                                                   20


<210>  2919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2919
cccagcccug ccauggccaa                                                   20


<210>  2920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2920
gaggugaaca ggaagcagaa                                                   20


<210>  2921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2921
gcuuccgcca cugccugagg                                                   20


<210>  2922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2922
uagacaacaa ugcaaggggg                                                   20


<210>  2923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2923
uugagcuaca caggcuaagc                                                   20


<210>  2924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2924
cccucucuca cucuugcuua                                                   20


<210>  2925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2925
gugcauggcc ucuaaacugg                                                   20


<210>  2926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2926
ccaauacccu aaugucuuau                                                   20


<210>  2927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2927
uaugcaauuu uugccaagau                                                   20


<210>  2928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2928
uggcaaaaau ugcauaagau                                                   20


<210>  2929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2929
cacugagcuc ugggccguuu                                                   20


<210>  2930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2930
caucucacug agcucugggc                                                   20


<210>  2931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2931
aaggggacga aaaguguuca                                                   20


<210>  2932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2932
cccuaaucuc caauuggcaa                                                   20


<210>  2933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2933
ccaauuggca aagccagacu                                                   20


<210>  2934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2934
cagaaccagu cuguauugcc                                                   20


<210>  2935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2935
uuaggaauga gcuaggaguu                                                   20


<210>  2936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2936
ccaaauguuc uuucuucagc                                                   20


<210>  2937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2937
guaaaauagg aauaauaaua                                                   20


<210>  2938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2938
ggcccuuucc ccaauuccua                                                   20


<210>  2939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2939
guguucccaa cugacuugcc                                                   20


<210>  2940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2940
uaacacagua gcugguaccu                                                   20


<210>  2941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2941
gguaccagcu acuguguuag                                                   20


<210>  2942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2942
cauauaggca ccuaucaggu                                                   20


<210>  2943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2943
aucacauaua ggcaccuauc                                                   20


<210>  2944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2944
gucgggcugu ccacccaucc                                                   20


<210>  2945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2945
aauucuccau caccaagaga                                                   20


<210>  2946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2946
ccaagagagc cuuccgaaag                                                   20


<210>  2947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2947
guggccguuu gcccaggggg                                                   20


<210>  2948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2948
gaggccaaac ccuuccugga                                                   20


<210>  2949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2949
caggcuccag gaaggguuug                                                   20


<210>  2950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2950
acucuuagac auaacacacc                                                   20


<210>  2951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2951
cuuuucuggc cuauguuauu                                                   20


<210>  2952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2952
gcuaucugcu cuuacuuaug                                                   20


<210>  2953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2953
gcucuuacuu augcacaccu                                                   20


<210>  2954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2954
cuuuucagcc aucucacuac                                                   20


<210>  2955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2955
cacuacagau aacucccaag                                                   20


<210>  2956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2956
guagugagau ggcugaaaag                                                   20


<210>  2957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2957
caggaauagc acccaagguc                                                   20


<210>  2958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2958
guaccucaga guagaacccc                                                   20


<210>  2959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2959
caacaggcag agaaugucug                                                   20


<210>  2960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2960
caacacauac gugugucugu                                                   20


<210>  2961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2961
cugugguuug agaguuugga                                                   20


<210>  2962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2962
gcacauacac acaaaaggua                                                   20


<210>  2963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2963
cuucucuuug guuuguuugu                                                   20


<210>  2964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2964
agaggucacc cucauaugug                                                   20


<210>  2965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2965
auugacuuuu cacauaugag                                                   20


<210>  2966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2966
uaaagccuuc auuaucaauu                                                   20


<210>  2967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2967
ccccuccggu uauccuaaag                                                   20


<210>  2968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2968
ucuccccucc gguuauccua                                                   20


<210>  2969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2969
auuuccugca caggugcauu                                                   20


<210>  2970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2970
cagaaaacca gaaccgggaa                                                   20


<210>  2971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2971
ugacuuaagc aauggaaguc                                                   20


<210>  2972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2972
gugguagccu guguugccuc                                                   20


<210>  2973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2973
cagugguguu acugaggggc                                                   20


<210>  2974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2974
cuuugccccu caguaacacc                                                   20


<210>  2975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2975
uccucucuuc ccucuuuccu                                                   20


<210>  2976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2976
uccacuuugc ugcagguuca                                                   20


<210>  2977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2977
uugccuugaa ccugcagcaa                                                   20


<210>  2978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2978
cuccugccuu guacaacccu                                                   20


<210>  2979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2979
accccuuccu caaaucuccc                                                   20


<210>  2980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2980
cccucacugg augucacagu                                                   20


<210>  2981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2981
agugagggag auuugaggaa                                                   20


<210>  2982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2982
cuuaugacug uccaugggga                                                   20


<210>  2983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2983
ugaagacaga aauuaagugc                                                   20


<210>  2984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2984
ugaaguaauc gugaagacag                                                   20


<210>  2985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2985
ggauuccaaa gggacuauaa                                                   20


<210>  2986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2986
agauuuaucg ugaaguaauc                                                   20


<210>  2987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2987
ugcuuccuuc caugugagag                                                   20


<210>  2988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2988
cuacuccucc cccaguguug                                                   20


<210>  2989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2989
ccuaagcuag agcuagagcu                                                   20


<210>  2990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2990
uuuuguaaag aggggggaaa                                                   20


<210>  2991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2991
uuuguaaaac gaagcaucgc                                                   20


<210>  2992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2992
ccuuuaacug cucuguuuga                                                   20


<210>  2993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2993
aacagagcag uuaaaggcga                                                   20


<210>  2994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2994
agucagauuu uucagaauau                                                   20


<210>  2995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2995
gacuugauca aacagagcag                                                   20


<210>  2996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2996
aucccuagaa acuagcccuc                                                   20


<210>  2997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2997
cuagaaacua gcccucaggu                                                   20


<210>  2998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2998
uuggccugcu aaccugaggg                                                   20


<210>  2999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  2999
gucuaccugg aauguucuaa                                                   20


<210>  3000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3000
ggaaucagcu agaaacucaa                                                   20


<210>  3001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3001
gcuagaaacu caaucggcuc                                                   20


<210>  3002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3002
gcucuuacca gucacuaccu                                                   20


<210>  3003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3003
uauaauggug augauaauga                                                   20


<210>  3004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3004
ccauuauagg auauggcacu                                                   20


<210>  3005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3005
ucaccauuau aggauauggc                                                   20


<210>  3006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3006
uaauggucau uaucaucacc                                                   20


<210>  3007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3007
ucauaauggu cauuaucauc                                                   20


<210>  3008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3008
ucaucauaau ggucauuauc                                                   20


<210>  3009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3009
aguggaagcu auuauuauua                                                   20


<210>  3010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3010
uuuacuuuuu uuggaaggcc                                                   20


<210>  3011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3011
ccuuacuaua ggcacauauu                                                   20


<210>  3012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3012
gcaaagggag aaaugagaca                                                   20


<210>  3013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3013
ucagcaaagg gagaaaugag                                                   20


<210>  3014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3014
aguagagaaa ugaucaaaag                                                   20


<210>  3015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3015
uuucucuacu ggaucaucag                                                   20


<210>  3016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3016
aaaggauccu gcacauuguc                                                   20


<210>  3017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3017
uuuugaucau uucucuacug                                                   20


<210>  3018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3018
ugcacauugu ccuaaaugaa                                                   20


<210>  3019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3019
ugcagaggaa gcuugguuuc                                                   20


<210>  3020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3020
ccuggcucac uuccauccug                                                   20


<210>  3021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3021
ucggccaaug aagcgguggg                                                   20


<210>  3022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3022
cugcaacacc cugaccuuua                                                   20


<210>  3023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3023
aagaggccca uggagguggg                                                   20


<210>  3024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3024
ccccaccucc augggccucu                                                   20


<210>  3025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3025
cucuuagcag ggcuggggug                                                   20


<210>  3026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3026
ccuccacacc uccauucucc                                                   20


<210>  3027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3027
ccacgcacca cuucugugcc                                                   20


<210>  3028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3028
cuguuggcau uaucuccacg                                                   20


<210>  3029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3029
gugccgacca agcacacaag                                                   20


<210>  3030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3030
ugugugcuug gucggcacug                                                   20


<210>  3031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3031
ugugggaccc cucuguccag                                                   20


<210>  3032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3032
cagggugugc ccugagaagg                                                   20


<210>  3033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3033
uccugguacc aggaaggcaa                                                   20


<210>  3034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3034
ugguaccagg aaggcaaugg                                                   20


<210>  3035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3035
ccucugcuca gcucugccca                                                   20


<210>  3036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3036
gaccccucua ccuacucaca                                                   20


<210>  3037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3037
uaugugagua gguagagggg                                                   20


<210>  3038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3038
guaaagagaa ggaagcaggc                                                   20


<210>  3039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3039
gccugcuucc uucucuuuac                                                   20


<210>  3040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3040
auagguccaa guucguacag                                                   20


<210>  3041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3041
gagaggcuuc cuuaagccac                                                   20


<210>  3042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3042
aucagagagg cuuccuuaag                                                   20


<210>  3043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3043
ugaucaaacu cagaugacug                                                   20


<210>  3044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3044
agauuuacag guaauucaaa                                                   20


<210>  3045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3045
aacucagaug acuguccaac                                                   20


<210>  3046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3046
gaguuugauc aagauuuaca                                                   20


<210>  3047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3047
agaaacuacg uuugucuaau                                                   20


<210>  3048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3048
augccccccc accacccacc                                                   20


<210>  3049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3049
guggaaugga aaaugaagaa                                                   20


<210>  3050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3050
aaagggaaga augcuacagc                                                   20


<210>  3051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3051
cccagaaaag ccagcgagaa                                                   20


<210>  3052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3052
cccuacaaug uguuccccag                                                   20


<210>  3053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3053
ucucuggucu cggggcccaa                                                   20


<210>  3054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3054
ggccacagaa ccuaaggccu                                                   20


<210>  3055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3055
acucgccuug cacauggcug                                                   20


<210>  3056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3056
ugccuuauuc cuucaggagc                                                   20


<210>  3057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3057
cuuagaggag uuacagaaug                                                   20


<210>  3058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3058
auaaaauggg gcuaauuucc                                                   20


<210>  3059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3059
gccuauuggg ccucaggcuc                                                   20


<210>  3060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3060
gucuucucuu ccuccuaauc                                                   20


<210>  3061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3061
auaagcacca gaccucaagc                                                   20


<210>  3062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3062
uaguccugcu ugaggucuag                                                   20


<210>  3063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3063
cacuggcagg cagccucagg                                                   20


<210>  3064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3064
agggcacagc cgcaggccuc                                                   20


<210>  3065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3065
cuaccugccc ccuguccccu                                                   20


<210>  3066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3066
gucagcccac agaggcacgg                                                   20


<210>  3067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3067
ucccagcagg aacuuacauc                                                   20


<210>  3068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3068
cagcaggaac uuacaucaga                                                   20


<210>  3069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3069
gagcaggcag ccuacccaag                                                   20


<210>  3070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3070
auacacguag ucccuuccau                                                   20


<210>  3071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3071
gccuuauacc uugucuuaua                                                   20


<210>  3072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3072
aaccuggaac ucacagucgg                                                   20


<210>  3073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3073
accaaggcuu gaagugaggu                                                   20


<210>  3074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3074
uaccuaucca ccaaggcuug                                                   20


<210>  3075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3075
gucuaacuug ggagccugag                                                   20


<210>  3076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3076
agcucaucug ucuaacuugg                                                   20


<210>  3077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3077
uucaucuacc accaauuucc                                                   20


<210>  3078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3078
accaccaauu uccuggcugu                                                   20


<210>  3079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3079
uacacauuuu accagugaag                                                   20


<210>  3080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3080
gcaaccccag guuggccaua                                                   20


<210>  3081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3081
uccucuguaa aaugggagaa                                                   20


<210>  3082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3082
uuggcacauc uucugaaaca                                                   20


<210>  3083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3083
ucugaaacaa gaccuguuuc                                                   20


<210>  3084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3084
aauuuugcac uuauuuauau                                                   20


<210>  3085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3085
aagcagaaug aagguagugu                                                   20


<210>  3086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3086
auaagagcac agguaagugu                                                   20


<210>  3087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3087
uauuacaaga guguucuuca                                                   20


<210>  3088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3088
cuuccaaaua cuuuaccugg                                                   20


<210>  3089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3089
caccauugca ccccagccug                                                   20


<210>  3090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3090
cggcucacca ccucugccuc                                                   20


<210>  3091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3091
cagcuacuca ggaggcugag                                                   20


<210>  3092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3092
cuauuaaaaa uauaaacuua                                                   20


<210>  3093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3093
ccugagguca agaguuugag                                                   20


<210>  3094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3094
acccaccucg gccucccaaa                                                   20


<210>  3095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3095
cacauaaaaa uuuaagacgg                                                   20


<210>  3096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3096
uccuguuuuc ccgucuuaaa                                                   20


<210>  3097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3097
gccccucugc cucucuacau                                                   20


<210>  3098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3098
caggcuaaca gagcuucagg                                                   20


<210>  3099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3099
gaaugauaug aauauuugua                                                   20


<210>  3100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3100
uucugauagu cuugaguugc                                                   20


<210>  3101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3101
auacaaauau ucauaucauu                                                   20


<210>  3102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3102
aagcaacaau cagagaucag                                                   20


<210>  3103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3103
gagaucaggu cccuccaaau                                                   20


<210>  3104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3104
cugauuguug cuuugauaag                                                   20


<210>  3105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3105
ggucccucca aaugagcuua                                                   20


<210>  3106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3106
uaaacuguaa gcucauuugg                                                   20


<210>  3107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3107
ugcuuuguaa aagcugguga                                                   20


<210>  3108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3108
uuuuguuuca ccagcuuuua                                                   20


<210>  3109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3109
aucauuuugu uucaccagcu                                                   20


<210>  3110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3110
gcuauccauc auuuuguuuc                                                   20


<210>  3111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3111
gaaaaagucu cagccuaaua                                                   20


<210>  3112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3112
gauucagaag aguagcaggg                                                   20


<210>  3113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3113
gaugaagaag uuauucuguc                                                   20


<210>  3114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3114
gugcuagcga gaaacccccu                                                   20


<210>  3115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3115
cacacuuugu acauacaauu                                                   20


<210>  3116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3116
cagaauugua uguacaaagu                                                   20


<210>  3117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3117
cagguauugc uccuaaagaa                                                   20


<210>  3118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3118
uccuccaaca uccaaaagca                                                   20


<210>  3119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3119
aaaagcagug uucacaccca                                                   20


<210>  3120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3120
caugcuuucu aauauuaaaa                                                   20


<210>  3121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3121
cuuuucacug guauuucuua                                                   20


<210>  3122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3122
agaacauuac aacacaaaga                                                   20


<210>  3123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3123
ucaucagaga aaaacaaauu                                                   20


<210>  3124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3124
ucagagaaaa acaaauuuac                                                   20


<210>  3125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3125
gagaaaaaca aauuuaccuc                                                   20


<210>  3126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3126
gagguaaauu uguuuuucuc                                                   20


<210>  3127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3127
ugguagcaca guagagcaga                                                   20


<210>  3128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3128
ccaauugagu gcucuuucug                                                   20


<210>  3129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3129
aaagaaauaa auucuagucc                                                   20


<210>  3130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3130
cuaagagaau caagucucga                                                   20


<210>  3131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3131
agucucgagu ggguaaaaug                                                   20


<210>  3132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3132
cccuagacag cccaggccuu                                                   20


<210>  3133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3133
uaauacacac ggaauguguu                                                   20


<210>  3134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3134
gggucugucc cuuccacaca                                                   20


<210>  3135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3135
acucugcauu uguccuggca                                                   20


<210>  3136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3136
ugggacuagg agugaccagg                                                   20


<210>  3137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3137
cccuugauca uguuagcccc                                                   20


<210>  3138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3138
agggugaugu ggcuucucca                                                   20


<210>  3139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3139
uguuagcccc auucugcagc                                                   20


<210>  3140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3140
gugaauaggu ggaggagagg                                                   20


<210>  3141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3141
auuagauugc ccaaaucugg                                                   20


<210>  3142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3142
aauggauagg agggaggguu                                                   20


<210>  3143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3143
gggaaaauaa uguguggcgc                                                   20


<210>  3144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3144
ggguguuugc ugagggcuuc                                                   20


<210>  3145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3145
ucuaggcggg uuaaauuagu                                                   20


<210>  3146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3146
uggcuccuaa aucuucuagg                                                   20


<210>  3147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3147
agaauauugu cccuugcagu                                                   20


<210>  3148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3148
uuugucagag cuuuauuauu                                                   20


<210>  3149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3149
aaaccuccug aaaauugguu                                                   20


<210>  3150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3150
acgaagcagc caauaaccaa                                                   20


<210>  3151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3151
gcuagaagcc ugcuggaagc                                                   20


<210>  3152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3152
cuguucuguu uggggagucc                                                   20


<210>  3153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3153
ugcaugcgug ccgguaggca                                                   20


<210>  3154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3154
augaugaaga ugcaguaccu                                                   20


<210>  3155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3155
uugauccugc augcgugccg                                                   20


<210>  3156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3156
ucaucauuga uccugcaugc                                                   20


<210>  3157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3157
ugcagugacu aagaaaggaa                                                   20


<210>  3158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3158
gaaugcuagg auaugacaca                                                   20


<210>  3159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3159
uagcauucag auagguggcc                                                   20


<210>  3160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3160
ggacacccag aaaaaauaau                                                   20


<210>  3161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3161
ccaaggcaaa aagcaaauag                                                   20


<210>  3162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3162
gcuguauuuc caggugagca                                                   20


<210>  3163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3163
agucuugaaa uuauauagag                                                   20


<210>  3164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3164
gguacauauc ugucccugaa                                                   20


<210>  3165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3165
gucccugaaa augcuuaaaa                                                   20


<210>  3166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3166
uuuaagcauu uucagggaca                                                   20


<210>  3167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3167
aacugauucc uaucacaugc                                                   20


<210>  3168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3168
guuugaucuu uuaagcauuu                                                   20


<210>  3169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3169
caugccuccc cuaccaguga                                                   20


<210>  3170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3170
agaacuccuu auacuucugg                                                   20


<210>  3171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3171
gaaucccuag ucuaccccug                                                   20


<210>  3172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3172
cuagucuacc ccugcggcug                                                   20


<210>  3173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3173
cauuuuuuuu uugaguaagc                                                   20


<210>  3174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3174
guauccucau uacuaacagc                                                   20


<210>  3175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3175
ucauuacuaa cagcacaaug                                                   20


<210>  3176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3176
cuuucgaaug uccauugugc                                                   20


<210>  3177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3177
ucuagcuuuu uuggcuuaug                                                   20


<210>  3178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3178
gagagaaaag aagggacgga                                                   20


<210>  3179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3179
gucccuucuu uucucuccga                                                   20


<210>  3180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3180
ggaagaaugg ggugccaaag                                                   20


<210>  3181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3181
cucaucaggu agucagccga                                                   20


<210>  3182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3182
gguagucagc cgagugaggc                                                   20


<210>  3183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3183
acacagggaa caagcgggug                                                   20


<210>  3184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3184
uuuuagaaua aaucauucgu                                                   20


<210>  3185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3185
uucguggcug acucuuaaau                                                   20


<210>  3186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3186
guaauuggcc cuucccauuu                                                   20


<210>  3187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3187
cugagaacaa cucuaccuga                                                   20


<210>  3188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3188
cucccaaaac aacggugggc                                                   20


<210>  3189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3189
gcaucccgua aauacccaga                                                   20


<210>  3190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3190
cguaaauacc cagaagcaau                                                   20


<210>  3191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3191
ggcagacgaa ccaggugggg                                                   20


<210>  3192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3192
ccacagcauc uggcagacga                                                   20


<210>  3193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3193
gguuucaccc gggcugcaaa                                                   20


<210>  3194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3194
ucucgcacca ucugguuuca                                                   20


<210>  3195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3195
cucauaggca agggauguua                                                   20


<210>  3196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3196
cuugccuaug agugauucac                                                   20


<210>  3197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3197
ccuuucccag ccauccuuug                                                   20


<210>  3198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3198
uuugacaccc accauagaaa                                                   20


<210>  3199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3199
cagagagguc agaaagaaca                                                   20


<210>  3200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3200
gaggaagagu caccuucaca                                                   20


<210>  3201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3201
aaugccacca ggcccugcca                                                   20


<210>  3202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3202
gaggaacacu gucugaaguu                                                   20


<210>  3203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3203
aggacagagc uggcucagga                                                   20


<210>  3204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3204
cauuuuucca gccucaguga                                                   20


<210>  3205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3205
uuagcccucu aagcagccau                                                   20


<210>  3206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3206
gugguaaaug cugccuucgc                                                   20


<210>  3207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3207
ggcguuuagg aggaaacaug                                                   20


<210>  3208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3208
auuuuucugu cagcaaccuc                                                   20


<210>  3209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3209
cagcauuaua gacauuauuu                                                   20


<210>  3210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3210
cauuuauaag uacccaugua                                                   20


<210>  3211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3211
gguagcaauu uaauuacauu                                                   20


<210>  3212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3212
aauuuaacuu gggauccaaa                                                   20


<210>  3213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3213
caaguuaaau uagauaaugc                                                   20


<210>  3214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3214
aaacuauuga aaagcaugug                                                   20


<210>  3215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3215
caugccuuac cagucagggu                                                   20


<210>  3216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3216
caacagacag agggccaagg                                                   20


<210>  3217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3217
uuggcccucu gucuguuggg                                                   20


<210>  3218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3218
gaaaauguaa aagcacuuca                                                   20


<210>  3219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3219
aaugcuccug uaacaaagga                                                   20


<210>  3220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3220
cauaguaugc uguccuuugu                                                   20


<210>  3221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3221
auaguaauua ucccauagua                                                   20


<210>  3222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3222
gcguguguaa uaugucuuuu                                                   20


<210>  3223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3223
uauggucuuc gguguugguu                                                   20


<210>  3224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3224
guaaccccau aggaaccaac                                                   20


<210>  3225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3225
gucgugcuca guuagggcau                                                   20


<210>  3226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3226
caauaaaccu gaaauucucu                                                   20


<210>  3227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3227
caaagaacca accuaaaauu                                                   20


<210>  3228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3228
acacuugguu caggacacag                                                   20


<210>  3229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3229
ggccuucccu guguccugaa                                                   20


<210>  3230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3230
cuagcacauu accuaguugg                                                   20


<210>  3231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3231
cggaggaaag caaaguccuc                                                   20


<210>  3232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3232
uagguaaccc aagggggagc                                                   20


<210>  3233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3233
cucaagguag gccuuagguu                                                   20


<210>  3234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3234
ugaggaccaa ggagcucucc                                                   20


<210>  3235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3235
cagaagaacc agugacaggu                                                   20


<210>  3236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3236
gacuccgaaa ucacaggcuu                                                   20


<210>  3237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3237
caggcuucug gucuaaagau                                                   20


<210>  3238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3238
uuagaccaga agccugugau                                                   20


<210>  3239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3239
aacaaauugc uuucuuguuu                                                   20


<210>  3240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3240
aagccagcca aagcugagac                                                   20


<210>  3241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3241
ucauaacauc caagccagcc                                                   20


<210>  3242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3242
guuguccucu uuuccacagg                                                   20


<210>  3243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3243
uuuccuggac uucucaggac                                                   20


<210>  3244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3244
ccaauuaaca gcagcucgau                                                   20


<210>  3245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3245
agcugcuguu aauuggugau                                                   20


<210>  3246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3246
uucuggauca aaagaucaag                                                   20


<210>  3247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3247
agaaagaugc gcuuuguuuc                                                   20


<210>  3248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3248
aaagaucaag uugucuuugg                                                   20


<210>  3249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3249
uuugauccag aaagaugcgc                                                   20


<210>  3250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3250
aguugucuuu gguagcuaaa                                                   20


<210>  3251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3251
uuuuguucuu uuuccuucuc                                                   20


<210>  3252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3252
ucucagcuau aggcagucaa                                                   20


<210>  3253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3253
cagcuauagg cagucaacug                                                   20


<210>  3254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3254
gggggcuacu cucuuucccc                                                   20


<210>  3255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3255
ugaggggaaa gagaguagcc                                                   20


<210>  3256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3256
uccugaacag ggcaguaguc                                                   20


<210>  3257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3257
acugaagucc ugaaguggug                                                   20


<210>  3258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3258
ucugagcacc uccacagccu                                                   20


<210>  3259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3259
caauaaacag caauucuauu                                                   20


<210>  3260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3260
ugacuccucc cuuccuuuca                                                   20


<210>  3261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3261
caccagucag caaauccugc                                                   20


<210>  3262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3262
ugccgguuuu cccuucgaag                                                   20


<210>  3263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3263
agccccuucu cacgucccca                                                   20


<210>  3264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3264
cuugccuaaa auuugccuuc                                                   20


<210>  3265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3265
cuccuccagu ggcuuccauc                                                   20


<210>  3266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3266
cccuuggagu cagagccaaa                                                   20


<210>  3267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3267
cugcucuacg uccuucaagg                                                   20


<210>  3268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3268
ucucaaaauu cucauggcca                                                   20


<210>  3269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3269
uauuuaaaag ccuggucacc                                                   20


<210>  3270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3270
aacugccugc acgaaaauaa                                                   20


<210>  3271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3271
ucucuugcca uacuauauaa                                                   20


<210>  3272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3272
ucugucucuc cccagcuaga                                                   20


<210>  3273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3273
auaaaacugu caggcagccc                                                   20


<210>  3274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3274
aaagcuaaag ugcccccagg                                                   20


<210>  3275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3275
uggguuugag ccagauucca                                                   20


<210>  3276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3276
ggcucaaacc caagauccaa                                                   20


<210>  3277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3277
cagugugccu ggaaacgcag                                                   20


<210>  3278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3278
aauacugugc aggggcacug                                                   20


<210>  3279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3279
cagcugccuc cacggcauua                                                   20


<210>  3280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3280
gaaagcaaga auggagggag                                                   20


<210>  3281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3281
cuucuaccug agagcccggg                                                   20


<210>  3282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3282
cgggcucuca gguagaaggg                                                   20


<210>  3283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3283
uuaaguguuu uauugguaac                                                   20


<210>  3284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3284
gagggaaaua uuagcauuau                                                   20


<210>  3285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3285
gauucaaaac ugaagacuca                                                   20


<210>  3286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3286
gauuagcgcu cuguuaacuu                                                   20


<210>  3287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3287
ucacucaguc aacguauuuu                                                   20


<210>  3288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3288
cucagucaac guauuuucca                                                   20


<210>  3289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3289
guaaaaugau gaggugcuuc                                                   20


<210>  3290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3290
uuuuacugau uuauuugaaa                                                   20


<210>  3291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3291
ucccagcaau guagguguuc                                                   20


<210>  3292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3292
gcagcucccc agcuccagug                                                   20


<210>  3293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3293
gaggaaagca ggcuuccucu                                                   20


<210>  3294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3294
ggcagccacc augagcaguu                                                   20


<210>  3295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3295
gcgcaucggg cagccaccau                                                   20


<210>  3296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3296
uucauuuggg cuuguggcug                                                   20


<210>  3297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3297
ugcucucagg uauaaaggau                                                   20


<210>  3298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3298
uuuauaccug agagcaagau                                                   20


<210>  3299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3299
gucuccuucu accugccccu                                                   20


<210>  3300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3300
ucucucaaag cugccuuucu                                                   20


<210>  3301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3301
caaugcucug cagagaguac                                                   20


<210>  3302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3302
aaugcuaaau uguaaaaagu                                                   20


<210>  3303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3303
agucucacuu uuuacaauuu                                                   20


<210>  3304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3304
gccucuccuc ucagcucuaa                                                   20


<210>  3305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3305
aauuggagau gguuucaaua                                                   20


<210>  3306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3306
ccaauuagau augcaaaaug                                                   20


<210>  3307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3307
aggcaucccu acguuacuug                                                   20


<210>  3308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3308
cuacguuacu ugaaguuggu                                                   20


<210>  3309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3309
ggcgacguuc acagccuuau                                                   20


<210>  3310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3310
gaggugacuc auacuugaga                                                   20


<210>  3311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3311
gucaucagag gugacucaua                                                   20


<210>  3312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3312
auuuggagga gacacagaga                                                   20


<210>  3313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3313
cugagacguc uaagagguga                                                   20


<210>  3314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3314
cugaaccucu ccucaaaugg                                                   20


<210>  3315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3315
ugaggacuca ccaccccacu                                                   20


<210>  3316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3316
auggauaguc uagccuguga                                                   20


<210>  3317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3317
auggauuuca gugggguggu                                                   20


<210>  3318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3318
uucucaucuu ugagcggcuc                                                   20


<210>  3319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3319
uugagcggcu cuuccccaga                                                   20


<210>  3320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3320
ugacucuggg gaagagccgc                                                   20


<210>  3321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3321
ccaucaugcc ccggacucca                                                   20


<210>  3322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3322
ugccccggac uccagucucu                                                   20


<210>  3323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3323
uggagccgug ucagcugcag                                                   20


<210>  3324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3324
gccgggugcu ucuggagaug                                                   20


<210>  3325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3325
ccagaagcac ccggcagaug                                                   20


<210>  3326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3326
gggcgcuggu uucugcugug                                                   20


<210>  3327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3327
ccucaagcca gccaccccau                                                   20


<210>  3328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3328
ucauguccug ucuggaucuu                                                   20


<210>  3329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3329
agacaggaca ugaagauuug                                                   20


<210>  3330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3330
ucccaguccu gcccucucuc                                                   20


<210>  3331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3331
ucccacccuu ccaagggccu                                                   20


<210>  3332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3332
aucuccccac ucacacgcua                                                   20


<210>  3333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3333
ccccacucac acgcuaaagu                                                   20


<210>  3334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3334
cugaucagga cugaaaaaag                                                   20


<210>  3335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3335
gggaugaguc cgugcuguug                                                   20


<210>  3336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3336
ggacugaaaa aagaaaaaga                                                   20


<210>  3337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3337
caccacucuc ugggaaaaua                                                   20


<210>  3338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3338
cuggcuuguu gagaagagag                                                   20


<210>  3339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3339
agggaguuuu gcucaccaca                                                   20


<210>  3340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3340
aggucucgac ucaauccagg                                                   20


<210>  3341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3341
ucagagaagg acagacuuga                                                   20


<210>  3342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3342
ccuuguggac uuuccugaga                                                   20


<210>  3343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3343
caccaguggc cgggguguuc                                                   20


<210>  3344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3344
cagugcugag ccaugagccc                                                   20


<210>  3345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3345
gaaaauagaa uuaaauagcc                                                   20


<210>  3346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3346
cagcauuuug ggaggccgag                                                   20


<210>  3347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3347
cuacuuaaaa aaaaaaaaaa                                                   20


<210>  3348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3348
gccaggugug auggcaugca                                                   20


<210>  3349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3349
caccuggcug auuuuuuuuu                                                   20


<210>  3350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3350
cagcuacuug ggaggcugag                                                   20


<210>  3351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3351
cuugaaccug ggaggcggag                                                   20


<210>  3352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3352
cggcucauug cagccuccgc                                                   20


<210>  3353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3353
uagcacugca cuccagccug                                                   20


<210>  3354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3354
caaaaaaaaa aaaaaauuaa                                                   20


<210>  3355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3355
gaguugugca aauaaaucua                                                   20


<210>  3356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3356
aguuggucug acugucuuua                                                   20


<210>  3357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3357
auggaauuca cagccucuua                                                   20


<210>  3358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3358
ucucuuauca auggaauuca                                                   20


<210>  3359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3359
aaggucuugc auacacauac                                                   20


<210>  3360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3360
ccuuuuaaac ucauccaaga                                                   20


<210>  3361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3361
aagagccagu caaagccacc                                                   20


<210>  3362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3362
uuaggucugg gcaacacuuu                                                   20


<210>  3363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3363
ucccccacgu gcuccuuccc                                                   20


<210>  3364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3364
gcaagcagag uucacugcuu                                                   20


<210>  3365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3365
caaccccagc acuuucacuu                                                   20


<210>  3366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3366
ccagcucccu guccagggaa                                                   20


<210>  3367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3367
auucaaagcc cggucuuucu                                                   20


<210>  3368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3368
agcagcguga gcaaaguaca                                                   20


<210>  3369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3369
guacuuugcu cacgcugcuu                                                   20


<210>  3370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3370
gugguauuca cauuggcucg                                                   20


<210>  3371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3371
ccuuuuaacu aaucccagag                                                   20


<210>  3372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3372
cagagugaca ccuccuccaa                                                   20


<210>  3373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3373
ccuucuagug ggcuggaccu                                                   20


<210>  3374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3374
gugggaccca gcuaccucuc                                                   20


<210>  3375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3375
cuguccgcca cccaccacca                                                   20


<210>  3376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3376
agagucauuu ggaagccccc                                                   20


<210>  3377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3377
cccaacuuuc cagcuucccc                                                   20


<210>  3378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3378
ccacaguaag accucacagu                                                   20


<210>  3379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3379
uucucgaauu gacuuguuca                                                   20


<210>  3380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3380
aauaagggaa uauucucugg                                                   20


<210>  3381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3381
cugcuucccu uuuucauaac                                                   20


<210>  3382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3382
agccuugugg ccauaagccu                                                   20


<210>  3383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3383
caggcuuaug gccacaaggc                                                   20


<210>  3384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3384
uagagcaccc aaagcuggca                                                   20


<210>  3385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3385
uccuacacac ucacugucac                                                   20


<210>  3386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3386
uacacacuca cugucaccuc                                                   20


<210>  3387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3387
uuucugugug cuggggugag                                                   20


<210>  3388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3388
gggcuccgcu cuuccaaaac                                                   20


<210>  3389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3389
ggagaacaaa gguuuuggaa                                                   20


<210>  3390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3390
ugucuccuaa ggugcccccu                                                   20


<210>  3391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3391
uaacucaccg ucauccgggg                                                   20


<210>  3392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3392
ggggaagugg agaggaaguc                                                   20


<210>  3393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3393
caggugcccc ucucuguccu                                                   20


<210>  3394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3394
ggacaacugg gagugaaagu                                                   20


<210>  3395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3395
uugagggcag uuaaacuuuc                                                   20


<210>  3396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3396
uugucagcca ucuuugaggg                                                   20


<210>  3397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3397
agcauuccua guggacacca                                                   20


<210>  3398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3398
augaagcacu gguuuuuaaa                                                   20


<210>  3399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3399
uaguguuuuc cacauucuuu                                                   20


<210>  3400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3400
ugccauugga cucuguaguu                                                   20


<210>  3401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3401
gacuaauguu ugaguaaaag                                                   20


<210>  3402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3402
gcugguuuuc cagcucuuuu                                                   20


<210>  3403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3403
uguaacccau uuauuguuuc                                                   20


<210>  3404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3404
auuaucuugu aacccauuua                                                   20


<210>  3405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3405
augaguucag guucaggaaa                                                   20


<210>  3406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3406
cuuuccugaa ccugaacuca                                                   20


<210>  3407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3407
ccagcuuugg gcugaaaugc                                                   20


<210>  3408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3408
caucaccagc uuugggcuga                                                   20


<210>  3409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3409
cuuaugcuuc auuuuaaacc                                                   20


<210>  3410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3410
aagguagaca aaaggaagga                                                   20


<210>  3411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3411
uuccuuuugu cuaccuucga                                                   20


<210>  3412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3412
caggaaaucc uuccuuuugu                                                   20


<210>  3413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3413
gccccugaga ggguacacgu                                                   20


<210>  3414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3414
acuccauuau cuccaguuau                                                   20


<210>  3415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3415
ccaguuaucu gaauaaaaaa                                                   20


<210>  3416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3416
gaauaaaaaa gccaagcuau                                                   20


<210>  3417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3417
ccugugcugu ugcagagaau                                                   20


<210>  3418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3418
ccgauaaaag cgugggugca                                                   20


<210>  3419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3419
gugauggcug gaaugcuuuu                                                   20


<210>  3420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3420
cacauggccu cuccauggcc                                                   20


<210>  3421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3421
guaaaaugac aggguuaaug                                                   20


<210>  3422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3422
uuaacccugu cauuuuacag                                                   20


<210>  3423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3423
ucuauguaga cauagacuug                                                   20


<210>  3424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3424
augcucaaag agcugugcuu                                                   20


<210>  3425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3425
uagaagaaag cacagcucuu                                                   20


<210>  3426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3426
cagaaauuug gaaggccaca                                                   20


<210>  3427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3427
ucccucugug gccuuccaaa                                                   20


<210>  3428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3428
cagcaauuau uuuauuuuau                                                   20


<210>  3429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3429
uuucaaagaa aauauaaaau                                                   20


<210>  3430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3430
aucaaaccua gaccuaaaau                                                   20


<210>  3431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3431
aaccuagacc uaaaaucauc                                                   20


<210>  3432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3432
ucuugucuca uucccucugu                                                   20


<210>  3433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3433
ugucucauuc ccucugucaa                                                   20


<210>  3434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3434
gcugagcucu cauaauacau                                                   20


<210>  3435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3435
uagauaaagg agucacagga                                                   20


<210>  3436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3436
augauguuuu auguauuaug                                                   20


<210>  3437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3437
ugugacuccu uuaucuauga                                                   20


<210>  3438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3438
cagacauuuu aaaacuaaau                                                   20


<210>  3439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3439
gcucuaucgc agacauuuua                                                   20


<210>  3440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3440
ugaaucugcu cuaucgcaga                                                   20


<210>  3441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3441
uacaggcaua auccugaauc                                                   20


<210>  3442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3442
cacaugugaa uuuuagcuuc                                                   20


<210>  3443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3443
agagcaaugc uuccugccuu                                                   20


<210>  3444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3444
gagaaucacc acacaccaga                                                   20


<210>  3445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3445
ccacacacca gagagggcau                                                   20


<210>  3446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3446
ucagaguuca cuuaaaaguc                                                   20


<210>  3447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3447
gaguucacuu aaaaguccau                                                   20


<210>  3448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3448
agaaucagaa cgugggaugg                                                   20


<210>  3449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3449
gaacguggga uggggugccc                                                   20


<210>  3450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3450
cacguucuga uucuggaugg                                                   20


<210>  3451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3451
acgcccggcc cccaggaaug                                                   20


<210>  3452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3452
auuacuguuc aaguucaggu                                                   20


<210>  3453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3453
agcuugaccu gaacuugaac                                                   20


<210>  3454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3454
acaugguguu gcucgauggg                                                   20


<210>  3455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3455
agcaacacca uguggauggu                                                   20


<210>  3456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3456
uugcccaucg agcaacacca                                                   20


<210>  3457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3457
agaggcaguc guucaccacc                                                   20


<210>  3458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3458
gcucccuaca auccacagca                                                   20


<210>  3459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3459
acagcaaaag gagaguuccu                                                   20


<210>  3460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3460
cucuuuaaaa gaaggaacuc                                                   20


<210>  3461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3461
cucaacucuu gagagaaaau                                                   20


<210>  3462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3462
cacuucuguc cauuuucucu                                                   20


<210>  3463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3463
ugauaccagc aggaaacagg                                                   20


<210>  3464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3464
ggauugaaaa aucccacuuc                                                   20


<210>  3465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3465
acaccuuuaa ggcauuuugc                                                   20


<210>  3466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3466
aaaagaccgc aaaaugccuu                                                   20


<210>  3467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3467
ccaggcagcu gaaagucagu                                                   20


<210>  3468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3468
gcuuuuuaau gaugugaaag                                                   20


<210>  3469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3469
uuaaaaagcu gauguacuga                                                   20


<210>  3470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3470
uuaacuuuca caucauuaaa                                                   20


<210>  3471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3471
cuccuuacag guuauagaca                                                   20


<210>  3472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3472
uaggaaaaag gugacugcac                                                   20


<210>  3473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3473
cuccugaaau cugacgugcu                                                   20


<210>  3474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3474
gacgugcuuu gcaacagcag                                                   20


<210>  3475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3475
uguagauuuc ugaggccagu                                                   20


<210>  3476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3476
acaagauucc agugguucca                                                   20


<210>  3477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3477
uguauucucc uaaauuacuc                                                   20


<210>  3478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3478
cuuugucuuc acugaguuuu                                                   20


<210>  3479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3479
uuuucauagg cauugucauu                                                   20


<210>  3480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3480
auaacucagg aauucauggc                                                   20


<210>  3481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3481
aagcauagcc augaauuccu                                                   20


<210>  3482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3482
ugucacuggc aagcaauuau                                                   20


<210>  3483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3483
ucuucaaaua auucggccua                                                   20


<210>  3484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3484
uacacacauu ugugcauaaa                                                   20


<210>  3485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3485
uuggcuuucu gaauuuuuca                                                   20


<210>  3486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3486
auauaccuug ccacgcaagg                                                   20


<210>  3487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3487
aaaauaauug caaaauuauu                                                   20


<210>  3488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3488
uucacaccuc augucuugaa                                                   20


<210>  3489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3489
aaauacuguu uugcaucauu                                                   20


<210>  3490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3490
gugaguauaa auucuggagu                                                   20


<210>  3491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3491
agugccacca aauuuuuuaa                                                   20


<210>  3492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3492
agauuauaaa aguaaagagc                                                   20


<210>  3493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3493
agauuuuaaa aaauuuggug                                                   20


<210>  3494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3494
cccuucggug ggauaaugua                                                   20


<210>  3495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3495
caccgaaggg ugaugcucuu                                                   20


<210>  3496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3496
ucacagaguu uucugaggaa                                                   20


<210>  3497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3497
aaggccacuu auuuaauuuu                                                   20


<210>  3498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3498
ucacucuccu uggugcuucu                                                   20


<210>  3499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3499
aaaagagcag acaguccccc                                                   20


<210>  3500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3500
acaggaaucu gaaggggcag                                                   20


<210>  3501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3501
gaaggggcag ccagacauuc                                                   20


<210>  3502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3502
gaucagccac caaccgaacc                                                   20


<210>  3503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3503
gauggguggu auaggcagaa                                                   20


<210>  3504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3504
gccaccaacc gaaccaaaaa                                                   20


<210>  3505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3505
uuuuuucugc aaagaagggg                                                   20


<210>  3506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3506
auaucuuuuu uucugcaaag                                                   20


<210>  3507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3507
ugcuggguug acaaagguug                                                   20


<210>  3508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3508
cuuuccaaaa aguguuuaga                                                   20


<210>  3509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3509
uugagggugc cagguuacau                                                   20


<210>  3510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3510
gcuguaaacc caaguaucag                                                   20


<210>  3511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3511
ggcacuuaga uggcagcuaa                                                   20


<210>  3512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3512
aagugccuga uacuuggguu                                                   20


<210>  3513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3513
gagaguggcg cuuuuagcug                                                   20


<210>  3514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3514
caccauuccc agacccaggc                                                   20


<210>  3515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3515
gcugccugga agcugagacu                                                   20


<210>  3516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3516
agaagaacaa aauuccccuu                                                   20


<210>  3517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3517
uccaucuugu gccccagucc                                                   20


<210>  3518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3518
ugugccccag uccucccuua                                                   20


<210>  3519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3519
ccucucaggc aaaucaucuu                                                   20


<210>  3520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3520
ucuuucucua auagccaggg                                                   20


<210>  3521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3521
uucucuaaua gccagggcuc                                                   20


<210>  3522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3522
gacucugccu caugcacuga                                                   20


<210>  3523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3523
cuugucuuuu ucagugcaug                                                   20


<210>  3524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3524
cuguucuucc aggagaaugg                                                   20


<210>  3525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3525
gggaaguuca uugugaaggg                                                   20


<210>  3526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3526
caaauacuac aaaaguagag                                                   20


<210>  3527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3527
guccccaagu ccacaucuuc                                                   20


<210>  3528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3528
uccagcucca accaccacag                                                   20


<210>  3529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3529
ccucccuagc ccauuuuauu                                                   20


<210>  3530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3530
acuuaaauaa uaaaaugggc                                                   20


<210>  3531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3531
cagacgucau aucauuucau                                                   20


<210>  3532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3532
uuucaucagu aaacaccucu                                                   20


<210>  3533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3533
guaaacaccu cuguauguau                                                   20


<210>  3534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3534
caccuaaaaa uaauaaaguc                                                   20


<210>  3535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3535
gggucauguu uuggaggauc                                                   20


<210>  3536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3536
uccaaaacau gacccagaug                                                   20


<210>  3537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3537
cuuccaguga gguucaagac                                                   20


<210>  3538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3538
cacucucuaa aaagggccuu                                                   20


<210>  3539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3539
acugccccac aggcccugag                                                   20


<210>  3540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3540
ccacauccga caagcaggug                                                   20


<210>  3541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3541
gacaagcagg ugcacuccca                                                   20


<210>  3542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3542
aagacaugcu cugugaauga                                                   20


<210>  3543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3543
agucagcugu auauccaaga                                                   20


<210>  3544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3544
ugucuaaaaa uaguauuugc                                                   20


<210>  3545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3545
auagguuuua uuguagaccu                                                   20


<210>  3546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3546
gccucuggaa cuagugcucc                                                   20


<210>  3547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3547
cugugucucu cuggagcacu                                                   20


<210>  3548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3548
uucaggauau aaaauaagua                                                   20


<210>  3549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3549
ugaaagauau uaaguccaac                                                   20


<210>  3550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3550
guacacaguu acuucuuacu                                                   20


<210>  3551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3551
gguuaaaugg acuucaguaa                                                   20


<210>  3552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3552
cccuucuuua cgguucugcc                                                   20


<210>  3553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3553
aggauuccug cuugggacug                                                   20


<210>  3554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3554
uggauggcag gcuguccuuu                                                   20


<210>  3555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3555
uaguggcaaa uuuaggagca                                                   20


<210>  3556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3556
ucaauccagc gcuaugugaa                                                   20


<210>  3557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3557
agcgcuaugu gaacaacaga                                                   20


<210>  3558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3558
gaaagucugu uguucacaua                                                   20


<210>  3559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3559
ccauacuauu uaucugaaag                                                   20


<210>  3560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3560
gacuuaagca aauuaucucc                                                   20


<210>  3561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3561
aaaucugacu uaagcaaauu                                                   20


<210>  3562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3562
auguagaaac cacuuuucau                                                   20


<210>  3563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3563
auauagaagu uuuugaaagc                                                   20


<210>  3564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3564
aaucaauaua gaaguuuuug                                                   20


<210>  3565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3565
uggugaauuc uaaagacuuu                                                   20


<210>  3566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3566
auauacacac auacauaugu                                                   20


<210>  3567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3567
uaugaugaca guguugaugu                                                   20


<210>  3568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3568
uaagauaaag cauauauaca                                                   20


<210>  3569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3569
acacugucau cauaagauaa                                                   20


<210>  3570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3570
ccaaacacau caacacuguc                                                   20


<210>  3571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3571
uucauugcca ggcaaaacuu                                                   20


<210>  3572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3572
uacgagcaca caggagcuca                                                   20


<210>  3573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3573
aguaaaugaa ucaccaaggc                                                   20


<210>  3574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3574
ccaaggcaca gaaagucacu                                                   20


<210>  3575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3575
caucuuaaac uucagccaga                                                   20


<210>  3576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3576
uaaacuucag ccagagaucu                                                   20


<210>  3577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3577
cuggcugaag uuuaagaugg                                                   20


<210>  3578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3578
aaaacuuuga agucaauuau                                                   20


<210>  3579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3579
ggggugcuuu auuguuugag                                                   20


<210>  3580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3580
ucauuuauca uccgcuccca                                                   20


<210>  3581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3581
uccgcuccca uuucgcaaac                                                   20


<210>  3582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3582
gcucccauuu cgcaaacaaa                                                   20


<210>  3583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3583
auauaucaca uugugacaca                                                   20


<210>  3584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3584
cauugugaca cagcugaccg                                                   20


<210>  3585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3585
ugcauuaaca auacaacggc                                                   20


<210>  3586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3586
gccguuguau uguuaaugca                                                   20


<210>  3587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3587
uaaacuucau gucugaauac                                                   20


<210>  3588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3588
cuggcaugaa uguuaucaug                                                   20


<210>  3589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3589
ugcuuuuauu ucagguaaua                                                   20


<210>  3590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3590
uaaaaaacaa gaaaaaagaa                                                   20


<210>  3591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3591
cugguaacaa aauaaaaucu                                                   20


<210>  3592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3592
gaaacagcug auuaccagug                                                   20


<210>  3593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3593
gcuguuucug auuuugcaug                                                   20


<210>  3594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3594
ccaaaacauu auaaauuaaa                                                   20


<210>  3595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3595
auagcuucaa uaaaaaggua                                                   20


<210>  3596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3596
caagagugcc uguguccuac                                                   20


<210>  3597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3597
guugugaaau auguguuccu                                                   20


<210>  3598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3598
caugugcuca gaguaagggg                                                   20


<210>  3599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3599
aaaacuuucu uuuauuaucc                                                   20


<210>  3600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3600
ucauuaucca aaggauaacu                                                   20


<210>  3601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3601
uuauccaaag gauaacuuug                                                   20


<210>  3602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3602
aaaggauaac uuugaaugcc                                                   20


<210>  3603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3603
uuuggauaau gaugaucuaa                                                   20


<210>  3604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3604
cauucaaugc cacauauaaa                                                   20


<210>  3605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3605
gugcuaaaag ccaaugguaa                                                   20


<210>  3606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3606
auuuuuuaaa cuugguguuu                                                   20


<210>  3607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3607
uugcaaucca uuuuuuaaac                                                   20


<210>  3608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3608
caugucccag aacaggccau                                                   20


<210>  3609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3609
uguagguaaa agcauauggc                                                   20


<210>  3610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3610
gaugccuuua acaagcaaaa                                                   20


<210>  3611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3611
gaugcaacau guuuagaaga                                                   20


<210>  3612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3612
cugaauucag ucaguuaauu                                                   20


<210>  3613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3613
aaauagaagu acguuuuuga                                                   20


<210>  3614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3614
uuuaauuguu gcaagcuguu                                                   20


<210>  3615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3615
uauaaggcug gaaacuucug                                                   20


<210>  3616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3616
ccauuccauu auacugcacu                                                   20


<210>  3617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3617
uucaaauugc uggaagcaaa                                                   20


<210>  3618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3618
cgaauccaag ccuuaaucuc                                                   20


<210>  3619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3619
aagccuuaau cuccaccaua                                                   20


<210>  3620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3620
ccaccauagc uuccaucuuu                                                   20


<210>  3621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3621
uugaggcaaa ucaagaaaau                                                   20


<210>  3622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3622
agaaaauaau auucugcugu                                                   20


<210>  3623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3623
aguugcugaa uggggcucac                                                   20


<210>  3624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3624
uggggacuua gagacccacc                                                   20


<210>  3625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3625
auuuuaccua cuuuacaaga                                                   20


<210>  3626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3626
cacagcauga uacaauaagg                                                   20


<210>  3627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3627
ugcugugaga uuuugggcuc                                                   20


<210>  3628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3628
gaaaaccagg acaccugggu                                                   20


<210>  3629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3629
gugucucucu guuaacacua                                                   20


<210>  3630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3630
guaaugccca aaagaccuua                                                   20


<210>  3631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3631
ucuuccuuca uucguguuug                                                   20


<210>  3632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3632
aaaauaguuu aucauaaugc                                                   20


<210>  3633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3633
uaaugcucuc aauuggaagg                                                   20


<210>  3634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3634
gccuguagua ugaagaccuu                                                   20


<210>  3635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3635
ucuaccagaa aauaacagua                                                   20


<210>  3636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3636
uuguuauaga aaaaaccuac                                                   20


<210>  3637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3637
agaaagugaa aucauuguua                                                   20


<210>  3638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3638
agauuugauc aaauucagaa                                                   20


<210>  3639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3639
agauuuugca gaaguucagg                                                   20


<210>  3640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3640
aaucuagauu uugcagaagu                                                   20


<210>  3641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3641
aauucagaaa cuggugauuu                                                   20


<210>  3642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3642
ccaguuucug aauuugauca                                                   20


<210>  3643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3643
aaucaccagu uucugaauuu                                                   20


<210>  3644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3644
aauucagaau cccauauuuu                                                   20


<210>  3645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3645
cauauuuugg gaugaugugu                                                   20


<210>  3646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3646
caaaauaugg gauucugaau                                                   20


<210>  3647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3647
ucccaaaaua ugggauucug                                                   20


<210>  3648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3648
uuuggggaag aaagagcaaa                                                   20


<210>  3649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3649
uuaaaaggau uucaacuuca                                                   20


<210>  3650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3650
uuuuaaagau gaaaacuauu                                                   20


<210>  3651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3651
gaaguugaaa uccuuuuaaa                                                   20


<210>  3652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3652
aaucaauaaa uaaauaagac                                                   20


<210>  3653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3653
auaaauaaau aagacaaaca                                                   20


<210>  3654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3654
uuuaccauuu gggaagugua                                                   20


<210>  3655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3655
gcaguaauua auguacacuu                                                   20


<210>  3656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3656
ccccccaccc ccucugcauc                                                   20


<210>  3657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3657
cagacagcag ugcucaaaag                                                   20


<210>  3658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3658
gggacaaaug agcucugauu                                                   20


<210>  3659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3659
gagcucauuu gucccugaug                                                   20


<210>  3660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3660
gcagcgcauu uagauuagcc                                                   20


<210>  3661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3661
aaaugcgcug cagauuaaaa                                                   20


<210>  3662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3662
uugggcuaau cuaaaugcgc                                                   20


<210>  3663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3663
aauuacacua ucuuugggcu                                                   20


<210>  3664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3664
gagaggaggc cuauaaacca                                                   20


<210>  3665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3665
ucuucuuuaa cacccuccug                                                   20


<210>  3666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3666
ugacuuuuac acaguuguca                                                   20


<210>  3667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3667
gacgcauuau aggucagccc                                                   20


<210>  3668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3668
cugcccagcc aacgcauucu                                                   20


<210>  3669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3669
cuagucaaca gcauugauuu                                                   20


<210>  3670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3670
augcuguuga cuagugauaa                                                   20


<210>  3671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3671
gguugaagua gaaauacuac                                                   20


<210>  3672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3672
aacagccucu uaaccagucc                                                   20


<210>  3673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3673
aauggugaga gcaauggaaa                                                   20


<210>  3674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3674
aggcacuugg ccugaagggu                                                   20


<210>  3675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3675
aauuugugcu uaccuaacga                                                   20


<210>  3676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3676
ucagagaugu ggccugauuu                                                   20


<210>  3677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3677
gagauguggc cugauuuuca                                                   20


<210>  3678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3678
cugaugaugg ccuuuuguuu                                                   20


<210>  3679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3679
ggccacaucu cugaugaugg                                                   20


<210>  3680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3680
gugaaaauca ggccacaucu                                                   20


<210>  3681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3681
uggcuuuaga acccuucuua                                                   20


<210>  3682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3682
uuucagcuuu aucauuucag                                                   20


<210>  3683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3683
uuucagucua ggagacccag                                                   20


<210>  3684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3684
auguggguca agagcuccaa                                                   20


<210>  3685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3685
caccucaaac ucagaagaca                                                   20


<210>  3686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3686
agguugucuu cugaguuuga                                                   20


<210>  3687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3687
caaagaaguu gucggucaca                                                   20


<210>  3688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3688
aucacaaaga aguugucggu                                                   20


<210>  3689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3689
gaacagccuc ccuugguucu                                                   20


<210>  3690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3690
gauacucgcc agugcugagg                                                   20


<210>  3691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3691
gaugggagcu cugcucacuu                                                   20


<210>  3692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3692
uuugguaguu gagaagcgcc                                                   20


<210>  3693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3693
uuucaaauug gccaggcuaa                                                   20


<210>  3694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3694
aucugcaacg aaccucaggu                                                   20


<210>  3695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3695
gcaacgaacc ucaggucuug                                                   20


<210>  3696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3696
gcauguggcu uccccagagg                                                   20


<210>  3697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3697
uauggagcug uugacugcag                                                   20


<210>  3698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3698
gcuucgagga gguuuucauu                                                   20


<210>  3699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3699
uccuaagaaa caccacugcc                                                   20


<210>  3700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3700
gaauuauaca gggagggaga                                                   20


<210>  3701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3701
uaccuucaaa ggcuggggag                                                   20


<210>  3702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3702
gagaaguaaa ugccacagag                                                   20


<210>  3703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3703
agugaggguc cugagaaaca                                                   20


<210>  3704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3704
guccagaaug agccugaaau                                                   20


<210>  3705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3705
ugcuuugcaa guagucauuu                                                   20


<210>  3706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3706
ucugggaaag agaagaaugu                                                   20


<210>  3707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3707
uuuggccugc ggccgccacc                                                   20


<210>  3708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3708
aggguuaaau gacuucccug                                                   20


<210>  3709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3709
cacaacaacc ucggaaagga                                                   20


<210>  3710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3710
augugucaga cacaugguaa                                                   20


<210>  3711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3711
ccauuucaca gagaggugaa                                                   20


<210>  3712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3712
uuucaccucu cugugaaaug                                                   20


<210>  3713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3713
gaacccagag uaacuguguc                                                   20


<210>  3714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3714
caaccugcuc accccauaau                                                   20


<210>  3715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3715
uaugagagca ugugggggcg                                                   20


<210>  3716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3716
cggggcuugc cucauagggc                                                   20


<210>  3717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3717
guaaaguggg gagaaucacg                                                   20


<210>  3718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3718
gcccaagguu gcacaacuag                                                   20


<210>  3719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3719
aagagaagaa gaaaagaaag                                                   20


<210>  3720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3720
ucuuucuuuu cuucuucucu                                                   20


<210>  3721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3721
uaugucaagg gcauauuucc                                                   20


<210>  3722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3722
aggugggaga gaagacugcc                                                   20


<210>  3723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3723
augggauaaa cccagaggcc                                                   20


<210>  3724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3724
cauggauacc ugcccccgcu                                                   20


<210>  3725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3725
ugccucccuu augaggccua                                                   20


<210>  3726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3726
cauuuacuuc cccuggcuag                                                   20


<210>  3727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3727
cauuuuauau agaugugcac                                                   20


<210>  3728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3728
auauaaaaug ugauaaaauc                                                   20


<210>  3729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3729
uagacuugaa aaggcaccau                                                   20


<210>  3730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3730
uuucagacag guccccaaac                                                   20


<210>  3731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3731
caccuagggg acaccagggc                                                   20


<210>  3732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3732
caauaacuuc cugacauuuu                                                   20


<210>  3733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3733
ucccaauaac uuccugacau                                                   20


<210>  3734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3734
ucuuggccuc uuccuguguu                                                   20


<210>  3735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3735
agaacaaaac aagcccaaac                                                   20


<210>  3736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3736
guccuggguc cugcccagga                                                   20


<210>  3737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3737
uucucagcca ccgacagcuu                                                   20


<210>  3738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3738
guggaaacuc uuuuuuuuuu                                                   20


<210>  3739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3739
ggcccucggg uuacuggcgu                                                   20


<210>  3740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3740
caacuuuuuu ucccaacggc                                                   20


<210>  3741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3741
uuccuggcuu gccguuggga                                                   20


<210>  3742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3742
ucuuuccugg cuugccguug                                                   20


<210>  3743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3743
aaugcucccu ggucuuuugg                                                   20


<210>  3744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3744
aaagccuggc ccucggccaa                                                   20


<210>  3745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3745
guuaauggac aaccacaacc                                                   20


<210>  3746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3746
auuaugucug cgcuuuuccc                                                   20


<210>  3747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3747
augucuaguu uuuaggagcu                                                   20


<210>  3748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3748
ugaauagaaa gggaaaagcg                                                   20


<210>  3749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3749
aucauucugu cugcuaaacc                                                   20


<210>  3750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3750
uucugucugc uaaaccaguc                                                   20


<210>  3751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3751
gcuccggaga aggugguaaa                                                   20


<210>  3752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3752
cguuggaccc acagaaucuu                                                   20


<210>  3753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3753
uuucgacccu cucacacuaa                                                   20


<210>  3754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3754
uauccauuaa uuuacccuga                                                   20


<210>  3755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3755
auuaauuuac ccugacuugc                                                   20


<210>  3756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3756
auuuuuguuu cauuaauauu                                                   20


<210>  3757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3757
cccagaccca gugggaaaua                                                   20


<210>  3758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3758
ggguuaaggc ucggaauccu                                                   20


<210>  3759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3759
ugcaccagcg uuggaagcug                                                   20


<210>  3760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3760
aacacaccca ccgcacaauc                                                   20


<210>  3761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3761
aaucuaauua agaucaggaa                                                   20


<210>  3762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3762
aauuaagauc aggaagaaau                                                   20


<210>  3763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3763
uaauuagauu cgauugugcg                                                   20


<210>  3764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3764
ggaagaaauu ugcauuuucu                                                   20


<210>  3765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3765
cagaaguucu ucaaauuuug                                                   20


<210>  3766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3766
cacugguggu cuauuaauag                                                   20


<210>  3767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3767
uaauacccag aguggcccag                                                   20


<210>  3768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3768
guaaaccagg cagagaguaa                                                   20


<210>  3769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3769
uuaugccaag gaauuuucuu                                                   20


<210>  3770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3770
gcaaacauau ccuuaugcca                                                   20


<210>  3771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3771
aauuucagau cauguguugu                                                   20


<210>  3772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3772
gaaauuugau cagcaaacau                                                   20


<210>  3773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3773
uguguuguuc auuauuauga                                                   20


<210>  3774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3774
cacuguggca aacuguuuuu                                                   20


<210>  3775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3775
aucucacugu ggcaaacugu                                                   20


<210>  3776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3776
accuuuaaaa aaauuguacu                                                   20


<210>  3777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3777
aaaccaguua augcuuuaaa                                                   20


<210>  3778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3778
guaaauuccc ugaaaauaca                                                   20


<210>  3779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3779
uguggcuuug cauaagucuu                                                   20


<210>  3780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3780
cauuagcucc uucaaaauca                                                   20


<210>  3781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3781
acccugggua cacuagauua                                                   20


<210>  3782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3782
aguguaccca ggguagauug                                                   20


<210>  3783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3783
auuagaauga aauuuguacu                                                   20


<210>  3784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3784
uucuugcugc uucuagggcu                                                   20


<210>  3785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3785
aggaguuuug ccaugucggu                                                   20


<210>  3786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3786
caagccuuau uauucagucu                                                   20


<210>  3787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3787
uaacaaggua aaaaguaaac                                                   20


<210>  3788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3788
cuuucuugua aaguuugggg                                                   20


<210>  3789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3789
cccccuucau uccuucucuc                                                   20


<210>  3790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3790
ugcaucaccc ccuucauucc                                                   20


<210>  3791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3791
cucuccuucu aucuugcauc                                                   20


<210>  3792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3792
acagccaacg cgacugaagc                                                   20


<210>  3793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3793
ucauacuuua uguggggcug                                                   20


<210>  3794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3794
auuagauuuc aucauaucuu                                                   20


<210>  3795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3795
aauggauaau uugcuauuug                                                   20


<210>  3796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3796
uaucuuagua aagcaauuac                                                   20


<210>  3797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3797
uaguaaagca auuacaucaa                                                   20


<210>  3798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3798
agaaaaugau agugcgugug                                                   20


<210>  3799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3799
uuuucuugau guaauugcuu                                                   20


<210>  3800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3800
auuaugcaug caguuggccg                                                   20


<210>  3801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3801
cucgacacac acaaauaaaa                                                   20


<210>  3802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3802
aggggcuuuu uauuugugug                                                   20


<210>  3803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3803
cacagaugga ccccaucagu                                                   20


<210>  3804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3804
gugagaucca ggggcuuuuu                                                   20


<210>  3805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3805
guucaucuua cugccuaaaa                                                   20


<210>  3806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3806
uacugccuaa aaaguucaug                                                   20


<210>  3807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3807
agaacacaaa uaaauuauua                                                   20


<210>  3808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3808
auaccaugcu aaaagcaugc                                                   20


<210>  3809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3809
caauuuauuu ucuuucauua                                                   20


<210>  3810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3810
gaauaucagu uacacuguuc                                                   20


<210>  3811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3811
guuacacugu ucugauucug                                                   20


<210>  3812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3812
gaacagugua acugauauuc                                                   20


<210>  3813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3813
cugguuaaca agcagaauca                                                   20


<210>  3814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3814
uugguuuaug aguuuaucac                                                   20


<210>  3815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3815
auaauacagc acagguuauu                                                   20


<210>  3816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3816
caggcucuca aaaaucggaa                                                   20


<210>  3817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3817
gaaaccguua guuagcaccu                                                   20


<210>  3818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3818
uggucuccag gcucccuggg                                                   20


<210>  3819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3819
ccaaaguaua uccuggucuc                                                   20


<210>  3820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3820
aguaaguuuu cucauucagc                                                   20


<210>  3821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3821
aaaagauaaa agagucagcc                                                   20


<210>  3822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3822
uuuagaucaa guaaguuuuc                                                   20


<210>  3823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3823
aucuaaagaa gaaaccuaaa                                                   20


<210>  3824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3824
aaagaagaaa ccuaaagcau                                                   20


<210>  3825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3825
gguuccuccu uuggaggagg                                                   20


<210>  3826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3826
aacugcuaac aauaaaacug                                                   20


<210>  3827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3827
ggaagugccu caaucauaua                                                   20


<210>  3828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3828
uauacuuaaa uuuuacaguc                                                   20


<210>  3829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3829
uucucauuug gggagaagac                                                   20


<210>  3830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3830
guuuucuuuu aacguuaagu                                                   20


<210>  3831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3831
ucuugccaag uuuccuuuag                                                   20


<210>  3832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3832
uuuugcuccu uucuacuggg                                                   20


<210>  3833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3833
gaggaggaga gccacugagg                                                   20


<210>  3834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3834
uguuuugugu auuagcugcc                                                   20


<210>  3835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3835
aaagugauua acaacagcuu                                                   20


<210>  3836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3836
cuuuugauca uguuuugugu                                                   20


<210>  3837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3837
uguaaauuaa auaugucaaa                                                   20


<210>  3838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3838
cuuggugaac uuuuaaucuu                                                   20


<210>  3839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3839
ugagaagaaa aaacacugcu                                                   20


<210>  3840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3840
ucaauuuugc aagauugaaa                                                   20


<210>  3841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3841
auuuugcaag auugaaaauc                                                   20


<210>  3842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3842
ugcaaaauug augauguaaa                                                   20


<210>  3843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3843
aagaaucuug gugcuauaaa                                                   20


<210>  3844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3844
uggugcuaua aacaauuuuc                                                   20


<210>  3845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3845
ggcuggccug ucagccugcu                                                   20


<210>  3846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3846
aaaaugcaaa acaauucgca                                                   20


<210>  3847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3847
ucaaaggcua aauugcuuua                                                   20


<210>  3848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3848
guaagauuca uccaaaaagc                                                   20


<210>  3849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3849
uacugauaau uugcuaaagc                                                   20


<210>  3850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3850
aaaaagcaaa ggguuuuucu                                                   20


<210>  3851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3851
uaggaagaaa aacccuuugc                                                   20


<210>  3852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3852
uccagacuga gcuuaaacua                                                   20


<210>  3853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3853
uagccccuuu ggcuugacua                                                   20


<210>  3854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3854
ucacggacuu uguucauaaa                                                   20


<210>  3855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3855
cuaaacaugg uaauuuauca                                                   20


<210>  3856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3856
aaaacagccc agagucgcuc                                                   20


<210>  3857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3857
guucuguugg aggacuaugc                                                   20


<210>  3858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3858
acugugguau aaaaacagcu                                                   20


<210>  3859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3859
uguugcuuga gauuugccuu                                                   20


<210>  3860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3860
caagcaacag gauuugcacu                                                   20


<210>  3861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3861
gaaaggcaaa ucucaagcaa                                                   20


<210>  3862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3862
auggugaacg ggucaugcag                                                   20


<210>  3863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3863
gcugacauuc agaaaguugu                                                   20


<210>  3864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3864
caccccaguu auuagagagu                                                   20


<210>  3865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3865
ugggaaccug gauuugcagg                                                   20


<210>  3866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3866
agguucccac gauacucucu                                                   20


<210>  3867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3867
uuugcuugaa ugcuaacuca                                                   20


<210>  3868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3868
cagcuggugu gcaagucaga                                                   20


<210>  3869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3869
ccacagcaga gagcuuuugg                                                   20


<210>  3870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3870
aagaauauuc caagaaccuc                                                   20


<210>  3871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3871
acucuaggag aaagucugag                                                   20


<210>  3872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3872
uaccggaaau guggauguua                                                   20


<210>  3873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3873
acauuuccgg uaagaucaac                                                   20


<210>  3874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3874
aggaaaucgg aaagagaagg                                                   20


<210>  3875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3875
gaaagagaag ggagaaaaau                                                   20


<210>  3876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3876
cagguacuac ccccugauuu                                                   20


<210>  3877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3877
ggggguagua ccugagauuu                                                   20


<210>  3878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3878
uugggcccug cucagaaaug                                                   20


<210>  3879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3879
uuucuaauaa auguuaaaau                                                   20


<210>  3880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3880
uauccuuucu aauaaauguu                                                   20


<210>  3881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3881
acaaccaucu guaugagcca                                                   20


<210>  3882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3882
guaugagcca cagguccaca                                                   20


<210>  3883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3883
acccucauug aacucuacuc                                                   20


<210>  3884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3884
cauaucaacc cucauugaac                                                   20


<210>  3885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3885
gaauuagauu aaaaacaaaa                                                   20


<210>  3886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3886
aauucugauu ugcccuguca                                                   20


<210>  3887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3887
cuugaaggca guuaggggaa                                                   20


<210>  3888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3888
caucagaaag uaaaguggaa                                                   20


<210>  3889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3889
gaaaguaaag uggaaugcau                                                   20


<210>  3890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3890
caaggcuucc uauaugcauu                                                   20


<210>  3891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3891
gcuuggggca gccugcugcc                                                   20


<210>  3892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3892
cuauuguaca aacaaguacg                                                   20


<210>  3893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3893
acuuguaugu agaauaagau                                                   20


<210>  3894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3894
uauucuacau acaaguggau                                                   20


<210>  3895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3895
uggagcugug ugacugguag                                                   20


<210>  3896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3896
gaagaaauac auagucuuug                                                   20


<210>  3897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3897
uugaaaacaa cugcuguccu                                                   20


<210>  3898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3898
aagaguaucu uuaucagaau                                                   20


<210>  3899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3899
uuaucagaau uaaauuuuuc                                                   20


<210>  3900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3900
gaauuaaauu uuuccuuauu                                                   20


<210>  3901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3901
auaaggaaaa auuuaauucu                                                   20


<210>  3902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3902
uaaccuucuc auguuauguu                                                   20


<210>  3903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3903
uucuucagua gccaauguuc                                                   20


<210>  3904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3904
cacccuaaua uuuuaaaaaa                                                   20


<210>  3905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3905
cgugaguuuc ucuccaucac                                                   20


<210>  3906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3906
uaaaucucgu gaguuucucu                                                   20


<210>  3907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3907
uuucaguuuc caguuaaaac                                                   20


<210>  3908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3908
gggcagggga guuaaaaugg                                                   20


<210>  3909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3909
uaaaaucaug guauaccuug                                                   20


<210>  3910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3910
ugguauaccu ugaguuggug                                                   20


<210>  3911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3911
cugcaccucc ucaaacaaaa                                                   20


<210>  3912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3912
aagcuacacu uuauuucccu                                                   20


<210>  3913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3913
guuaauuuuu agggaaauaa                                                   20


<210>  3914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3914
caucuguuaa uuuuuaggga                                                   20


<210>  3915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3915
uuacauauua agaaaaugaa                                                   20


<210>  3916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3916
guuguucauu uucuuaauau                                                   20


<210>  3917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3917
gggcauuuaa auuuauauuc                                                   20


<210>  3918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3918
guggauucgc cucuaucuaa                                                   20


<210>  3919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3919
acugauuaaa aacucccauu                                                   20


<210>  3920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3920
aaaacuaaaa ucaaauugua                                                   20


<210>  3921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3921
aauuguaggu gcaauuguuc                                                   20


<210>  3922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3922
ccuucaucaa cauaccugcu                                                   20


<210>  3923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3923
acauaccugc uccagguucc                                                   20


<210>  3924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3924
gucucugcca gagaauuccc                                                   20


<210>  3925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3925
ggaaaagggu gugcaaggcg                                                   20


<210>  3926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3926
gguuuaaacu uccuguaaaa                                                   20


<210>  3927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3927
ucucaccuuu agguauauau                                                   20


<210>  3928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3928
caccuuuagg uauauauaau                                                   20


<210>  3929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3929
aucuaaagag aucaaaaagg                                                   20


<210>  3930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3930
aaagagauca aaaagggcaa                                                   20


<210>  3931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3931
cuuuagauag auaaaauacc                                                   20


<210>  3932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3932
aaaagggcaa aagauggagc                                                   20


<210>  3933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3933
uuugcccuuu uugaucucuu                                                   20


<210>  3934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3934
ugcacugcgc guugccuuag                                                   20


<210>  3935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3935
uccagcagca uugcaucaga                                                   20


<210>  3936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3936
gauccacuca caucagucuc                                                   20


<210>  3937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3937
gaugcaaugc ugcuggaaga                                                   20


<210>  3938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3938
acucacauca gucuccaggg                                                   20


<210>  3939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3939
gucuccaggg ugaaccaaga                                                   20


<210>  3940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3940
cuugguucac ccuggagacu                                                   20


<210>  3941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3941
acaaaacgua uaaagaaaaa                                                   20


<210>  3942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3942
accacaacug cuucugacag                                                   20


<210>  3943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3943
acagcuguca gaagcaguug                                                   20


<210>  3944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3944
ucuuuaaaac cucaagcaau                                                   20


<210>  3945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3945
aaaggacuuc uguaccuuca                                                   20


<210>  3946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3946
guacuagauu uaaacugaau                                                   20


<210>  3947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3947
aguacugauc uaaaggacuu                                                   20


<210>  3948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3948
ccacaaauau uuacacugua                                                   20


<210>  3949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3949
cauacuuuua acgggaaaag                                                   20


<210>  3950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3950
uuuucuucuc uuggaguugu                                                   20


<210>  3951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3951
uccuuuucuu cucuuggagu                                                   20


<210>  3952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3952
auagcgaaau gaaaacauca                                                   20


<210>  3953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3953
aaggagaaca agaauggaaa                                                   20


<210>  3954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3954
agcauuuuuc cauugcuguc                                                   20


<210>  3955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3955
aaguuuauac aauuccccag                                                   20


<210>  3956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3956
gacagggcau uuacaugcgc                                                   20


<210>  3957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3957
gagcggcacc ugagagcucc                                                   20


<210>  3958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3958
cagcagggaa uaggugagcu                                                   20


<210>  3959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3959
gaagugaccu caccaccccc                                                   20


<210>  3960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3960
uucccuugcc aaccuaacuc                                                   20


<210>  3961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3961
guuuuaaaau guaacuuauu                                                   20


<210>  3962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3962
gacuguauuu cuaaucaguu                                                   20


<210>  3963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3963
aguauacugg cuuuaauaau                                                   20


<210>  3964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3964
gccuuugguc ucuaggagca                                                   20


<210>  3965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3965
guaaauuuac cuuuguaauu                                                   20


<210>  3966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3966
uuaaacagcu ucuccccuuu                                                   20


<210>  3967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3967
auuaaauuau auagucugaa                                                   20


<210>  3968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3968
aaauugauac auaacauaaa                                                   20


<210>  3969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3969
auuuggauga cauuaaugaa                                                   20


<210>  3970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3970
agcagguuuu uauguuaugu                                                   20


<210>  3971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3971
uuuuuuuuaa uccuugaaau                                                   20


<210>  3972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3972
uugaaauaac aacacugcug                                                   20


<210>  3973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3973
gaacaagcag aaagguacua                                                   20


<210>  3974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3974
uuaguaccuu ucugcuuguu                                                   20


<210>  3975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3975
ccaagcaucu uuaguaccuu                                                   20


<210>  3976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3976
caugcuaaaa aaguggcaag                                                   20


<210>  3977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3977
agcuggaccc agccuggcac                                                   20


<210>  3978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3978
acuuugguug gucuguucac                                                   20


<210>  3979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3979
agugacgcaa ucuuggugca                                                   20


<210>  3980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3980
uggugcaucu cccuagcugu                                                   20


<210>  3981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3981
cccuagcugu gcuuucuacu                                                   20


<210>  3982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3982
caaaaaucua aaaaauguuu                                                   20


<210>  3983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3983
aaaaaauguu ucccuaggau                                                   20


<210>  3984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3984
uagggaaaca uuuuuuagau                                                   20


<210>  3985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3985
uuaauuucac acugcagcuu                                                   20


<210>  3986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3986
uuuagagucc uggaaaauca                                                   20


<210>  3987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3987
aacucgccuc cucccugagc                                                   20


<210>  3988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3988
gaaauauguu uugcacaccu                                                   20


<210>  3989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3989
uuuauaguaa aggcacaacu                                                   20


<210>  3990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3990
ccccauuccu uguuguguug                                                   20


<210>  3991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3991
ccacaucaca cacaggauga                                                   20


<210>  3992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3992
cacacaggau gaucuucaua                                                   20


<210>  3993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3993
ugugugugau guggagauug                                                   20


<210>  3994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3994
uccugugugu gauguggaga                                                   20


<210>  3995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3995
ucauaucacg uggaccuauu                                                   20


<210>  3996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3996
cguggaccua uucucaaaac                                                   20


<210>  3997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3997
uuuauaaaua auguuuugag                                                   20


<210>  3998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3998
uuucuguguc accacaaggg                                                   20


<210>  3999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  3999
caaacuucuu cagacauuac                                                   20


<210>  4000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4000
uuaggaucuu cuacauuuua                                                   20


<210>  4001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4001
uaaagauccc aaacuucuuc                                                   20


<210>  4002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4002
ucuacauuuu agauauauuu                                                   20


<210>  4003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4003
aaaauguaga agauccuaaa                                                   20


<210>  4004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4004
ugcaaucacu gugacaguuc                                                   20


<210>  4005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4005
cugugacagu ucuauuuaca                                                   20


<210>  4006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4006
aagcugccag uucacaaccu                                                   20


<210>  4007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4007
aaagacuaau guucaugaaa                                                   20


<210>  4008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4008
uagguacuua uuagaaaaca                                                   20


<210>  4009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4009
agagaguaga gaauauuguu                                                   20


<210>  4010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4010
cauaaauaaa gagaaaagaa                                                   20


<210>  4011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4011
uccaguucag ucugagcuag                                                   20


<210>  4012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4012
gaauggauac aaaaagaaaa                                                   20


<210>  4013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4013
auucugauuc ucuccuagcu                                                   20


<210>  4014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4014
aauacaauau gcuuuucaga                                                   20


<210>  4015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4015
cccuucuuua gaguaucugu                                                   20


<210>  4016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4016
gucugauaua ucauuaucua                                                   20


<210>  4017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4017
gacagauacu cuaaagaagg                                                   20


<210>  4018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4018
uuaucuaaau accagcuaua                                                   20


<210>  4019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4019
aaauaccagc uauacugucu                                                   20


<210>  4020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4020
ggguauuuaa aauuauuugc                                                   20


<210>  4021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4021
ugaacauaga cauuuauauc                                                   20


<210>  4022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4022
acaggagcag acuuuacuac                                                   20


<210>  4023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4023
uuaaauuagg uuugggcugu                                                   20


<210>  4024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4024
gacaugaugg gauaauguuu                                                   20


<210>  4025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4025
ugucagauuu gagguuuugg                                                   20


<210>  4026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4026
caucauguca gauuugaggu                                                   20


<210>  4027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4027
uccaugaaua uuucccccca                                                   20


<210>  4028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4028
uaaaauauga gacuaaaaaa                                                   20


<210>  4029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4029
gcagccuuug acuugcaguc                                                   20


<210>  4030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4030
gaggguggau auuugacaca                                                   20


<210>  4031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4031
acccucagau aucagcagcc                                                   20


<210>  4032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4032
auaugugugu caaauaucca                                                   20


<210>  4033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4033
uugaaguagu auuaauuuag                                                   20


<210>  4034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4034
caauggauca caaucacaca                                                   20


<210>  4035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4035
auugagauca uugaaguagu                                                   20


<210>  4036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4036
caaucacaca auauuuugaa                                                   20


<210>  4037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4037
cacaauauuu ugaauauuua                                                   20


<210>  4038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4038
gguugcuuuu uucauuuuau                                                   20


<210>  4039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4039
auguguacag cucauaugug                                                   20


<210>  4040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4040
acguacacau augagcugua                                                   20


<210>  4041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4041
auucaccagg uaaaaagaau                                                   20


<210>  4042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4042
ucuaaaaaau acucaguuug                                                   20


<210>  4043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4043
cagcacuuug ggaggccaag                                                   20


<210>  4044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4044
accuggcuug gccucccaaa                                                   20


<210>  4045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4045
ccugagguca ggaguucaag                                                   20


<210>  4046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4046
cagcuacuug ggaggcugag                                                   20


<210>  4047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4047
cuugaaccua ggaggcagag                                                   20


<210>  4048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4048
ugccacugca cuccagccug                                                   20


<210>  4049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4049
ugaguaaaau gguaugcauu                                                   20


<210>  4050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4050
gaaagucccg aauucuaagc                                                   20


<210>  4051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4051
uaggaagaag aucugucacu                                                   20


<210>  4052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4052
ucuuccuaag auaaauaaag                                                   20


<210>  4053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4053
gucacuguuu uauucuugcu                                                   20


<210>  4054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4054
aacuuacauc acuuuaauaa                                                   20


<210>  4055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4055
cuuuaauaaa gccuuuccua                                                   20


<210>  4056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4056
cuagaagaau guguuuggca                                                   20


<210>  4057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4057
auauaucucu uuccuuaaua                                                   20


<210>  4058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4058
cuuuccuuaa uacaaggcau                                                   20


<210>  4059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4059
acugaaugau uacuguuauu                                                   20


<210>  4060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4060
uucaguagau auuugaauug                                                   20


<210>  4061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4061
uaaaaagaaa agcagacuug                                                   20


<210>  4062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4062
cgacuucuca uaauucacag                                                   20


<210>  4063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4063
cacuuugaga ugugaccaca                                                   20


<210>  4064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4064
caaagugaga ugucaguaac                                                   20


<210>  4065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4065
ccuguuccca cccuggaacu                                                   20


<210>  4066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4066
agacuuugua auuauucaug                                                   20


<210>  4067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4067
uagacaucuu agagagcuuu                                                   20


<210>  4068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4068
uagagagcuu uucgucucag                                                   20


<210>  4069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4069
uuuaacugag acgaaaagcu                                                   20


<210>  4070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4070
aucauuuaac ugagacgaaa                                                   20


<210>  4071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4071
cuuauuuccc uacauagauu                                                   20


<210>  4072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4072
auguagggaa auaagagaua                                                   20


<210>  4073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4073
aaaugcuggg gggaaggccu                                                   20


<210>  4074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4074
aagacugaau aaccuauuug                                                   20


<210>  4075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4075
agcugcucgu uuaaaagaca                                                   20


<210>  4076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4076
uauuuacaua ucgagcugcu                                                   20


<210>  4077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4077
cgcaaguguu acuccauauu                                                   20


<210>  4078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4078
ccaaauaugg aguaacacuu                                                   20


<210>  4079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4079
aaagccuugc uaaaucacca                                                   20


<210>  4080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4080
ccgaagacga caaauccccu                                                   20


<210>  4081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4081
ccuuccgccu gcucuugcuu                                                   20


<210>  4082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4082
ugccuuacac uucuguucau                                                   20


<210>  4083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4083
ugcugggggg uaggggagau                                                   20


<210>  4084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4084
ccccuacccc ccagcaggau                                                   20


<210>  4085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4085
ucaccuacau gucacauaag                                                   20


<210>  4086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4086
accacauuua ccuuauguga                                                   20


<210>  4087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4087
gcugcuaggg aagcugcauu                                                   20


<210>  4088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4088
gagugcuauc acagaaagca                                                   20


<210>  4089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4089
cagaaagcac uaaaaaaaga                                                   20


<210>  4090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4090
uuaaaaccaa acauggcauu                                                   20


<210>  4091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4091
aauucuagag ggggagagga                                                   20


<210>  4092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4092
ccucuagacc acugaccuau                                                   20


<210>  4093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4093
auucaugaua ugcacuaccu                                                   20


<210>  4094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4094
ugaauugauu cacuggaacu                                                   20


<210>  4095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4095
accuaccacc cagcucccga                                                   20


<210>  4096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4096
cuuucuucca ucuaccuacc                                                   20


<210>  4097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4097
accaacaggc auggcauguc                                                   20


<210>  4098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4098
cagaaucugc auugacuuuu                                                   20


<210>  4099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4099
gcauugacuu uugucuaaca                                                   20


<210>  4100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4100
cuuagagaag ggaauuuaag                                                   20


<210>  4101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4101
agauacaucu gucaaaacca                                                   20


<210>  4102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4102
ugauuuuguu ugugguuuac                                                   20


<210>  4103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4103
gucaaaacca caucagagac                                                   20


<210>  4104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4104
gagacaagag agagcacaga                                                   20


<210>  4105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4105
uuuagcugag gaggcaggcu                                                   20


<210>  4106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4106
uaaagucaag gucauggugu                                                   20


<210>  4107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4107
caccacgggg cuguguuuaa                                                   20


<210>  4108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4108
gggcugacag ccaauaugga                                                   20


<210>  4109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4109
auauuggcug ucagcccgga                                                   20


<210>  4110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4110
aaggcuagcc cugaagcuca                                                   20


<210>  4111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4111
ggccaggccu ccuuaggggu                                                   20


<210>  4112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4112
ccaccuucuc auuuugaagu                                                   20


<210>  4113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4113
aaaaucgaca gauccagaga                                                   20


<210>  4114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4114
acagauccag agagaaggug                                                   20


<210>  4115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4115
gucgauuuug gauuucuuuu                                                   20


<210>  4116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4116
agagagaagg ugucugaugu                                                   20


<210>  4117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4117
gacaccuucu cucuggaucu                                                   20


<210>  4118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4118
ugccuacauc ugauucagug                                                   20


<210>  4119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4119
gauucaguga gguggaaaau                                                   20


<210>  4120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4120
gauguaggca ggauagguac                                                   20


<210>  4121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4121
uuucuguugc uuacguccag                                                   20


<210>  4122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4122
agaggaauuu gccccaaaca                                                   20


<210>  4123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4123
acgucaucua gaggaauuug                                                   20


<210>  4124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4124
ucauccucug gcgugaccug                                                   20


<210>  4125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4125
ucuggcguga ccuggaugcc                                                   20


<210>  4126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4126
aggucacgcc agaggaugac                                                   20


<210>  4127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4127
cguggagguu ggcauccagg                                                   20


<210>  4128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4128
aaucccgugg agguuggcau                                                   20


<210>  4129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4129
cgauugguga aggggaaggu                                                   20


<210>  4130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4130
agaugaaaaa agcauccaau                                                   20


<210>  4131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4131
acagcuuuuu cuaagcagag                                                   20


<210>  4132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4132
agcacaaacg gaaacaaugc                                                   20


<210>  4133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4133
ggcacugccc acaggugagg                                                   20


<210>  4134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4134
ugaccuccuc accugugggc                                                   20


<210>  4135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4135
ccuucuggag cucccaacgg                                                   20


<210>  4136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4136
ucuguaagaa uggcuucaag                                                   20


<210>  4137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4137
guaagaaugg cuucaagagg                                                   20


<210>  4138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4138
caaccccaug ccaucccacc                                                   20


<210>  4139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4139
caccacauca uguaaagugu                                                   20


<210>  4140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4140
uguaaagugu uucuaggcuu                                                   20


<210>  4141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4141
uuguacuuuu uguaugcuca                                                   20


<210>  4142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4142
accagagagc aaauuuguca                                                   20


<210>  4143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4143
ucacauaugu aaagaaaaca                                                   20


<210>  4144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4144
cauauguaaa gaaaacaguc                                                   20


<210>  4145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4145
acuuuuuuuu uuaaccaguu                                                   20


<210>  4146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4146
guuucauagg ugcaugcagu                                                   20


<210>  4147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4147
aaauaauaau caugucgcag                                                   20


<210>  4148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4148
ugucgcagca uaauucacac                                                   20


<210>  4149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4149
aagaaauacc aaaugcacgg                                                   20


<210>  4150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4150
cauuuagcua augugucuga                                                   20


<210>  4151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4151
augauauaaa aaucagaaug                                                   20


<210>  4152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4152
uagaugccac caagugcaaa                                                   20


<210>  4153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4153
gaauggucaa gcaaacacca                                                   20


<210>  4154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4154
ccagcggaug guauaacaag                                                   20


<210>  4155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4155
gcuggugauu augugugcag                                                   20


<210>  4156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4156
acuuuaccag cuucuaucau                                                   20


<210>  4157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4157
uuuuuuaagc uuccaaaggg                                                   20


<210>  4158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4158
uaugcuugcu cuaucaaaaa                                                   20


<210>  4159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4159
aaaaaaaaaa aaaaaucaca                                                   20


<210>  4160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4160
caaaauacaa aacauccagg                                                   20


<210>  4161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4161
aggaugcugc caguuaauaa                                                   20


<210>  4162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4162
uggauguuuu guauuuugug                                                   20


<210>  4163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4163
gucugaccuu cuuuagcaag                                                   20


<210>  4164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4164
aaaaauagau uuuaauuuga                                                   20


<210>  4165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4165
auuuuuugau ucucuguggc                                                   20


<210>  4166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4166
guuccaauau ucuacacuca                                                   20


<210>  4167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4167
aaaucuguuc caauauucua                                                   20


<210>  4168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4168
agugaacuca gguuaaauuu                                                   20


<210>  4169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4169
ucccccucaa uauucagccu                                                   20


<210>  4170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4170
ggaguaacuc ccagaugugc                                                   20


<210>  4171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4171
gggaguuacu ccagaucuuc                                                   20


<210>  4172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4172
cauaauuucu agccucuggu                                                   20


<210>  4173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4173
uuuggccagu auguugggca                                                   20


<210>  4174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4174
uuaauucaga caacaggaau                                                   20


<210>  4175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4175
auguguacuu aaaauccuua                                                   20


<210>  4176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4176
aacuuacuag uacauagaac                                                   20


<210>  4177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4177
uaacggugga aauaaaaaau                                                   20


<210>  4178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4178
aauaguuaaa gguaaugugg                                                   20


<210>  4179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4179
guucagucac uacauuuaga                                                   20


<210>  4180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4180
aaaccgggaa augaaguggu                                                   20


<210>  4181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4181
gcaaccucug aauuaccacu                                                   20


<210>  4182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4182
uguuauuuuc aagaacuuug                                                   20


<210>  4183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4183
ucuuguuauu uucaagaacu                                                   20


<210>  4184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4184
aauguacaga uauaaaaccu                                                   20


<210>  4185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4185
guacauuuga ucaucuuguu                                                   20


<210>  4186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4186
gucuccuugc aaaacauuug                                                   20


<210>  4187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4187
uugcugguau auuauuaaaa                                                   20


<210>  4188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4188
gacaaagugg gacacaaaga                                                   20


<210>  4189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4189
guagacuaca ccaugagaau                                                   20


<210>  4190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4190
uuucucagug gcaaucaaca                                                   20


<210>  4191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4191
acauuuccuu ucugggcauc                                                   20


<210>  4192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4192
gauaauuucu cugcauuuua                                                   20


<210>  4193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4193
gaugcccaga aaggaaaugu                                                   20


<210>  4194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4194
uccuucgccc caacaauacc                                                   20


<210>  4195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4195
aggacucccu gcuuuguagc                                                   20


<210>  4196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4196
uaauaauuag ccgcgaauuc                                                   20


<210>  4197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4197
cagucuguca cugagacauu                                                   20


<210>  4198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4198
cuuuccucuc uguguaguug                                                   20


<210>  4199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4199
uuauaggaaa uguugguaag                                                   20


<210>  4200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4200
cccuuucccc cucccccucc                                                   20


<210>  4201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4201
aggagaagga cuuggaaagc                                                   20


<210>  4202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4202
ccgcacacac cucaagcgcg                                                   20


<210>  4203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4203
caggacccgc gcuugaggug                                                   20


<210>  4204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4204
cccaaaguaa aaaguguaag                                                   20


<210>  4205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4205
cugcaaaugc auuucccccg                                                   20


<210>  4206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4206
uuaugaugau aacuauuacu                                                   20


<210>  4207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4207
uaaugaugcg ggcaggcagc                                                   20


<210>  4208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4208
ucauaaugau gcgggcaggc                                                   20


<210>  4209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4209
caacaauagu aauaguuauc                                                   20


<210>  4210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4210
cccucuucgg ccaugccccg                                                   20


<210>  4211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4211
ccccguaugu cuuuguucuu                                                   20


<210>  4212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4212
ccgggcagga ggugggggag                                                   20


<210>  4213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4213
agaaagcuca gcgaacuuga                                                   20


<210>  4214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4214
uguucugccu ccuagcgacc                                                   20


<210>  4215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4215
cgguccucag uaccaccccc                                                   20


<210>  4216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4216
ugggacacuc uaggcuggga                                                   20


<210>  4217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4217
uuccgaagaa gggccugacu                                                   20


<210>  4218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4218
gacgcggcgc gcggcggugu                                                   20


<210>  4219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4219
gcauccggcg cggccggggg                                                   20


<210>  4220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4220
ggcgcggccg ggggaguugg                                                   20


<210>  4221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4221
cucccucgcc gcucuccccc                                                   20


<210>  4222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4222
aaaauuuaaa guaagaauca                                                   20


<210>  4223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4223
uaaauugagu agggggggaa                                                   20


<210>  4224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4224
ugggaccccg agcacuucac                                                   20


<210>  4225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4225
agcgcccuua aaaugcacac                                                   20


<210>  4226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4226
gcugggugaa acucggcuuu                                                   20


<210>  4227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4227
cccacccggc gcccggcgcc                                                   20


<210>  4228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4228
ggggcugggc uggggcgcgg                                                   20


<210>  4229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4229
cgugucugaa uguuuacaag                                                   20


<210>  4230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4230
aaauccacuu ccacuuuuuu                                                   20


<210>  4231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4231
acuuccacuu uuuuugaaaa                                                   20


<210>  4232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4232
uccaaaaaau aguaagagga                                                   20


<210>  4233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4233
cccucuuccc ccaaaccccu                                                   20


<210>  4234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4234
agaaaaaaau uuacaaucac                                                   20


<210>  4235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4235
cucaucuaga aaaaaauuua                                                   20


<210>  4236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4236
cacaaucucu caucuagaaa                                                   20


<210>  4237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4237
ccacaauagu gagaaagugg                                                   20


<210>  4238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4238
uuuuuuagac uuguacucac                                                   20


<210>  4239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4239
uugcauuccu uuucgaaaag                                                   20


<210>  4240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4240
ggaaccauug ccguguaugc                                                   20


<210>  4241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4241
caucuggaac cauugccgug                                                   20


<210>  4242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4242
cuuuuaccuc gacucucgga                                                   20


<210>  4243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4243
cgagagcgcg caggacuaga                                                   20


<210>  4244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4244
ggagagccgg guuagaaaga                                                   20


<210>  4245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4245
ucaucagugc cuuuugacau                                                   20


<210>  4246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4246
gugccuuuug acauccaaaa                                                   20


<210>  4247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4247
aaaauaaauu agaaauaaua                                                   20


<210>  4248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4248
uuguauuauu ucuaauuuau                                                   20


<210>  4249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4249
ucccugcgcc aucuuuguau                                                   20


<210>  4250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4250
cucuucucuc ucucucccuc                                                   20


<210>  4251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4251
cucucucucu cucucccucu                                                   20


<210>  4252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4252
agacuccuga cguucaaguu                                                   20


<210>  4253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4253
ggggcuggac augaaaaaga                                                   20


<210>  4254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4254
uucauuuuag aguccgcgug                                                   20


<210>  4255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4255
cccgaaguug agagcugagc                                                   20


<210>  4256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4256
agccuaaguu uggagggcug                                                   20


<210>  4257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4257
gagcgccccg ccaagcgacu                                                   20


<210>  4258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4258
cucugugcuu uugcaguugc                                                   20


<210>  4259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4259
caccaccgug gucuccccgc                                                   20


<210>  4260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4260
cacgccagag ugaagcccgc                                                   20


<210>  4261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4261
cagggggugc uguugcugua                                                   20


<210>  4262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4262
ccccggcggc ggcggcggcg                                                   20


<210>  4263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4263
caguccgauu ccaaaucugg                                                   20


<210>  4264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4264
gacugcgauc uccccggcgg                                                   20


<210>  4265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4265
ggaaggaguu ggggggagag                                                   20


<210>  4266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4266
accugcagcu cagggucucg                                                   20


<210>  4267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4267
cccucuucag ucuaaagggu                                                   20


<210>  4268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4268
cgcagcccug ccggcaagcg                                                   20


<210>  4269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4269
aaaccuccuu uucuuccuua                                                   20


<210>  4270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4270
cucucaaugu ugagcaucaa                                                   20


<210>  4271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4271
caguacagcc cacaucucuc                                                   20


<210>  4272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4272
ucccgcuucu uaaacagaau                                                   20


<210>  4273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4273
cuauuccacc acagucugcu                                                   20


<210>  4274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4274
ggcucacuau uguuaccuga                                                   20


<210>  4275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4275
gaaaagcuug guucugaaag                                                   20


<210>  4276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4276
auagagaaga uauauaaaug                                                   20


<210>  4277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4277
ucucuauaga uggacuuuua                                                   20


<210>  4278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4278
uacauauaua uauauuucca                                                   20


<210>  4279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4279
ucagagcgca cacaauugug                                                   20


<210>  4280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4280
gggcugcuau cuguggcuau                                                   20


<210>  4281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4281
guggcuauuu ccaauaaaua                                                   20


<210>  4282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4282
auaaaauguu gccaguuauu                                                   20


<210>  4283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4283
gaaacaagug caauaacaua                                                   20


<210>  4284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4284
uaaaacauac auuaaaaagc                                                   20


<210>  4285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4285
ucgcugcuua ccucuccuuu                                                   20


<210>  4286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4286
uaauaugccc agggugaaau                                                   20


<210>  4287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4287
ggcuggggga ggggcgggag                                                   20


<210>  4288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4288
aaugccgaca cacagccgug                                                   20


<210>  4289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4289
cuccuggucg ucgacccccc                                                   20


<210>  4290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4290
agcagugcug agggaggggu                                                   20


<210>  4291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4291
uucuuuaaac acacauacaa                                                   20


<210>  4292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4292
cuuaaaacga cacaucuuuc                                                   20


<210>  4293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4293
auacuuacgu aauauuuuaa                                                   20


<210>  4294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4294
uuaaucaaua cuuacguaau                                                   20


<210>  4295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4295
aagugugcgc auuuaaagug                                                   20


<210>  4296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4296
ugcccgcgga ggagacgccc                                                   20


<210>  4297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4297
gaggcagaau auauacugca                                                   20


<210>  4298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4298
ccguacuuaa uagccaaguc                                                   20


<210>  4299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4299
acucaacucu aaaaauacgg                                                   20


<210>  4300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4300
auacccuaau gcagugagag                                                   20


<210>  4301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4301
uacaggauuu cauaguccuu                                                   20


<210>  4302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4302
uguaugauuu acacucucuc                                                   20


<210>  4303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4303
ucgguccgag ggcugggacu                                                   20


<210>  4304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4304
ccuggcgcga ggaacucggg                                                   20


<210>  4305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4305
uccagcucag cccgaguucc                                                   20


<210>  4306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4306
ugacagaccu uuuaacccuu                                                   20


<210>  4307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4307
uguaguuucc auccugacag                                                   20


<210>  4308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4308
uugagucuau gaagguguuu                                                   20


<210>  4309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4309
uucauucagu cauucacuua                                                   20


<210>  4310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4310
uuuccuucuu gauuuuuacu                                                   20


<210>  4311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4311
agaaggaaau gauuguauuu                                                   20


<210>  4312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4312
ucauaaaaau aaaacuuagg                                                   20


<210>  4313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4313
aaaccuaagu uuuauuuuua                                                   20


<210>  4314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4314
uugagaccca aaauacaaaa                                                   20


<210>  4315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4315
cagcacuuug ggaagccgag                                                   20


<210>  4316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4316
ucccaccucg gcuucccaaa                                                   20


<210>  4317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4317
cuugagguca ggaguucaag                                                   20


<210>  4318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4318
cuacuaaaaa uacaaaaaau                                                   20


<210>  4319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4319
cuugaaccug ggggacagag                                                   20


<210>  4320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4320
uggcucacug caaccucugu                                                   20


<210>  4321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4321
caucacugca cuccagcccg                                                   20


<210>  4322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4322
cugcacucca gcccgggcaa                                                   20


<210>  4323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4323
ucuuccacaa gcaacucccu                                                   20


<210>  4324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4324
auaccuucua caaaggcaca                                                   20


<210>  4325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4325
cucaaggagg cuccugggag                                                   20


<210>  4326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4326
uucucuccag gcucccuggg                                                   20


<210>  4327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4327
aaagaaaaag gaaaaggaaa                                                   20


<210>  4328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4328
agaggaaagu auagacuuag                                                   20


<210>  4329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4329
aagacacaga ggugcugggc                                                   20


<210>  4330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4330
gcacacagua gauguccaau                                                   20


<210>  4331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4331
acugugugcu gauuauugca                                                   20


<210>  4332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4332
aagaccauuu auuggacauc                                                   20


<210>  4333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4333
gauaaauaau aauuugauaa                                                   20


<210>  4334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4334
gauaacuuua uuaauuuauu                                                   20


<210>  4335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4335
aauuauuauu uaucagauaa                                                   20


<210>  4336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4336
uaucaccaca uacaugaaac                                                   20


<210>  4337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4337
ccacauacau gaaaccaaca                                                   20


<210>  4338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4338
aaauucuauu cauuuucccc                                                   20


<210>  4339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4339
aagccuuauu aguuuugggg                                                   20


<210>  4340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4340
ggcaacccua uuccaagagu                                                   20


<210>  4341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4341
cuuuuauguu uaaacacacu                                                   20


<210>  4342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4342
uuggugggaa ucacuuuuau                                                   20


<210>  4343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4343
uuucugagcu caccauccuu                                                   20


<210>  4344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4344
cgaauaucag agcagcugaa                                                   20


<210>  4345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4345
gagcagcuga acaaguaaca                                                   20


<210>  4346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4346
uguauuguua cuuguucagc                                                   20


<210>  4347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4347
ucuccagcag cauacauuau                                                   20


<210>  4348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4348
aauaucuucc aaauaagcca                                                   20


<210>  4349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4349
uccaaauaag ccaguaucaa                                                   20


<210>  4350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4350
auaagcuggu aucaaaugau                                                   20


<210>  4351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4351
aaugauuucu uuuuuuuuuu                                                   20


<210>  4352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4352
uuugauacca gcuuauugau                                                   20


<210>  4353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4353
aaaagcaaug uuaaaaaaaa                                                   20


<210>  4354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4354
aaacaaccaa aaauaaaagg                                                   20


<210>  4355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4355
aguuugaaau accuuuuauu                                                   20


<210>  4356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4356
uuuaccuuua gcaagggaau                                                   20


<210>  4357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4357
uaaaaacaac cuucaccuau                                                   20


<210>  4358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4358
ggucugacau uuuguacagc                                                   20


<210>  4359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4359
cauugggcug aagcuggcug                                                   20


<210>  4360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4360
guccagaugu gaacuuguuu                                                   20


<210>  4361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4361
ggacugauaa cuugaauucu                                                   20


<210>  4362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4362
aaaagcuucc ucagcugagu                                                   20


<210>  4363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4363
cucucucucc ucuuucucuc                                                   20


<210>  4364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4364
cuucuguuuc ucucucucuc                                                   20


<210>  4365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4365
gaaacuacua aaaacauucu                                                   20


<210>  4366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4366
caaagaguac uuguccaaau                                                   20


<210>  4367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4367
uggaguaugu augugugggu                                                   20


<210>  4368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4368
agacuauaug ccaaggaaug                                                   20


<210>  4369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4369
gaagguagca cagaaugcau                                                   20


<210>  4370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4370
gaggugcuuu auuuuuccuu                                                   20


<210>  4371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4371
ucuuaauccu gucuaccaac                                                   20


<210>  4372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4372
uaauccuguc uaccaacugu                                                   20


<210>  4373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4373
ugucuaccaa cuguguggua                                                   20


<210>  4374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4374
uauuucauaa aagguacagc                                                   20


<210>  4375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4375
cuugguuugu uuggaaggca                                                   20


<210>  4376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4376
ugaguuaccc aaggacugua                                                   20


<210>  4377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4377
gucaacaguc aaagucaagc                                                   20


<210>  4378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4378
aucugucaac agucaaaguc                                                   20


<210>  4379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4379
gguggaccag aguuuugaaa                                                   20


<210>  4380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4380
cccauaaaca uuaguuucau                                                   20


<210>  4381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4381
ucacccauaa acauuaguuu                                                   20


<210>  4382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4382
gccacaucau cacccauaaa                                                   20


<210>  4383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4383
uuguuuuccu caugcauaua                                                   20


<210>  4384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4384
uuaccaccac cauccuuguu                                                   20


<210>  4385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4385
ucauuaccac caccauccuu                                                   20


<210>  4386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4386
ucaucauuac caccaccauc                                                   20


<210>  4387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4387
ccaccaucau caucauuacc                                                   20


<210>  4388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4388
ccaccaccgc caccucuauc                                                   20


<210>  4389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4389
ucaccaccac cgccaccucu                                                   20


<210>  4390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4390
ucaucaccac caccgccacc                                                   20


<210>  4391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4391
ccaccaguau caucaucacc                                                   20


<210>  4392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4392
ccaucaccac caguaucauc                                                   20


<210>  4393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4393
gcacuaccuu cuccaucacc                                                   20


<210>  4394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4394
uauuucuacu gcccucuggu                                                   20


<210>  4395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4395
uucauccuau uucuacugcc                                                   20


<210>  4396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4396
uguugcuuua gaaaagccac                                                   20


<210>  4397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4397
gguggcggac aaguuaaagu                                                   20


<210>  4398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4398
agccaagguc acauuuuggu                                                   20


<210>  4399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4399
gcauucagaa aucuuuucac                                                   20


<210>  4400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4400
uuucacuuuc agaagagcag                                                   20


<210>  4401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4401
cagucagagg gaauagagga                                                   20


<210>  4402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4402
gaccaccaaa uuaggccacu                                                   20


<210>  4403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4403
aagccugugg uccucagugg                                                   20


<210>  4404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4404
uucucacuuc acaauagcuu                                                   20


<210>  4405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4405
aaacauguca ccaggcucaa                                                   20


<210>  4406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4406
cacacaaaaa aagucuuaau                                                   20


<210>  4407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4407
cucugucauc uuucuuuggc                                                   20


<210>  4408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4408
uucuuuggca gcuuaguaga                                                   20


<210>  4409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4409
cucuauucuc ccauucccag                                                   20


<210>  4410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4410
uugcacaagu ucaguuaucu                                                   20


<210>  4411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4411
gaaccuccag auuccuauaa                                                   20


<210>  4412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4412
ggagguucag auaacugaac                                                   20


<210>  4413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4413
gguccuaaga auuguuauuc                                                   20


<210>  4414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4414
uauguuugca cagugcagug                                                   20


<210>  4415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4415
aaaagcaggg accacaucuu                                                   20


<210>  4416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4416
uccaaaagca gggaccacau                                                   20


<210>  4417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4417
uauuuuguau agcccuagcu                                                   20


<210>  4418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4418
ucgcuauagg uuuagaaccg                                                   20


<210>  4419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4419
augugaggca acacagcucu                                                   20


<210>  4420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4420
ggugucagag ugaccagagc                                                   20


<210>  4421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4421
aguuuuucuc cagaaaguac                                                   20


<210>  4422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4422
augaccagac cucauuauuu                                                   20


<210>  4423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4423
gugaucaucu aucucuauca                                                   20


<210>  4424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4424
cagauaucua ugaccagacc                                                   20


<210>  4425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4425
ucuaucucua ucacaguuuu                                                   20


<210>  4426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4426
aucucuauca caguuuuuau                                                   20


<210>  4427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4427
cuaucacagu uuuuauaaug                                                   20


<210>  4428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4428
caguuuuuau aauguuuuca                                                   20


<210>  4429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4429
uggcucacug caacuucugc                                                   20


<210>  4430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4430
cagcuacuca ggagguugag                                                   20


<210>  4431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4431
cgugagguca ggaguucgag                                                   20


<210>  4432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4432
acccaccuca gucucccaaa                                                   20


<210>  4433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4433
cagcacuuug ggagacugag                                                   20


<210>  4434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4434
aggaaugaau uccacaaaua                                                   20


<210>  4435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4435
gggggaaaca auuacauguc                                                   20


<210>  4436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4436
guguauauau guguguauaa                                                   20


<210>  4437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4437
uuguauauau gucauaaaag                                                   20


<210>  4438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4438
cccaaguccu aaguuguuag                                                   20


<210>  4439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4439
uucucucccu cagcacagag                                                   20


<210>  4440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4440
aagugguuua cuuuguaagu                                                   20


<210>  4441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4441
uaucuaccau agacaaaaug                                                   20


<210>  4442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4442
accauagaca aaauguccuu                                                   20


<210>  4443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4443
gagaauugag aacaauaaaa                                                   20


<210>  4444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4444
uaacagagua acucugagag                                                   20


<210>  4445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4445
gccuccagaa uuagucucuc                                                   20


<210>  4446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4446
agaccugucu agcugguuuu                                                   20


<210>  4447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4447
cuguuugggg guguauggga                                                   20


<210>  4448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4448
guauaugcuc uugacauaug                                                   20


<210>  4449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4449
uaugucaaga gcauauacug                                                   20


<210>  4450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4450
ugaacucaga gcuuaauuag                                                   20


<210>  4451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4451
acuaauuaag cucugaguuc                                                   20


<210>  4452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4452
uuagcaaaac ccccuuaugu                                                   20


<210>  4453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4453
auaaucuuua gcaaaacccc                                                   20


<210>  4454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4454
uuugcuugua uugauuuaaa                                                   20


<210>  4455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4455
auacaagcaa aagaucuaua                                                   20


<210>  4456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4456
acucuccuuc augggaacau                                                   20


<210>  4457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4457
aacagaggca gccuccaacc                                                   20


<210>  4458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4458
uauaauuuuu uuuuaaaaga                                                   20


<210>  4459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4459
uggaauucug aagacauuac                                                   20


<210>  4460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4460
aucuuggaau ucugaagaca                                                   20


<210>  4461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4461
uuucuuucca cugauguuca                                                   20


<210>  4462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4462
guggaaagaa acgauccauc                                                   20


<210>  4463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4463
agccccuuaa augugaacau                                                   20


<210>  4464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4464
cuuuaacuua augugaccaa                                                   20


<210>  4465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4465
uacugagggu aaaauagcug                                                   20


<210>  4466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4466
ugucaaucuu acugagggua                                                   20


<210>  4467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4467
gauuuguagu aacaaccaaa                                                   20


<210>  4468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4468
gauaucaugu caaucuuacu                                                   20


<210>  4469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4469
ucuuccuucu aaaauguuua                                                   20


<210>  4470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4470
auagugacaa ucuucuuccu                                                   20


<210>  4471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4471
ggggcuuuuu ugucccuuuu                                                   20


<210>  4472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4472
uuuauuaauu uuuuuaggaa                                                   20


<210>  4473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4473
cucauuccua aaaaaauuaa                                                   20


<210>  4474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4474
ugagguacau uuuuuucaac                                                   20


<210>  4475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4475
uauuauuuca gugcaaguuu                                                   20


<210>  4476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4476
ucuuauuauu ucagugcaag                                                   20


<210>  4477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4477
cucugcuugu uacucuggcc                                                   20


<210>  4478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4478
ccuaauguua cacugagagg                                                   20


<210>  4479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4479
cccauuaguc accacagcac                                                   20


<210>  4480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4480
uucugcuugc uguuugggca                                                   20


<210>  4481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4481
auaauacugg agacauaaau                                                   20


<210>  4482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4482
ucuugauuuu gauaggcauu                                                   20


<210>  4483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4483
agaggauaaa aauaauuuuu                                                   20


<210>  4484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4484
aaaucaagag gauaaaaaua                                                   20


<210>  4485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4485
uacccuuucu augcaaaugc                                                   20


<210>  4486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4486
ugaaggaugu gcugaugauu                                                   20


<210>  4487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4487
uucaugauag uggaauucca                                                   20


<210>  4488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4488
gcacauccuu caugauagug                                                   20


<210>  4489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4489
ucagcacauc cuucaugaua                                                   20


<210>  4490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4490
caagucuauu guacuuaauu                                                   20


<210>  4491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4491
ucaccagaac cucuuucuua                                                   20


<210>  4492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4492
ugcuuccucc cuguaucuuc                                                   20


<210>  4493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4493
ucccugaaug uuccuguguc                                                   20


<210>  4494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4494
ccaacuaaag aguauaugaa                                                   20


<210>  4495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4495
cucacuaaac ugaaaccccu                                                   20


<210>  4496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4496
ccaccucaag accaaggugc                                                   20


<210>  4497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4497
uaucuccacc ucaagaccaa                                                   20


<210>  4498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4498
aaucuuaucu ccaccucaag                                                   20


<210>  4499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4499
uaauugaaau uacacccaga                                                   20


<210>  4500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4500
ggcauccaga accaaacagg                                                   20


<210>  4501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4501
agaaccaaac aggccugagu                                                   20


<210>  4502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4502
ucuuugugga agcuguccau                                                   20


<210>  4503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4503
gucaagaagg gcugaaagaa                                                   20


<210>  4504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4504
aagguauccu uggaacucag                                                   20


<210>  4505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4505
uuggaacuca gagccaauaa                                                   20


<210>  4506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4506
aaagguacac uacacauuug                                                   20


<210>  4507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4507
uaagcaaaga acaaaugugu                                                   20


<210>  4508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4508
uuuaaaaccc uaguuccaug                                                   20


<210>  4509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4509
auuggguggc uuuuccucgc                                                   20


<210>  4510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4510
gcauagacuu acuuauucau                                                   20


<210>  4511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4511
auuuucaagg aaucagggac                                                   20


<210>  4512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4512
gggacuuagu ccuauaacuu                                                   20


<210>  4513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4513
uaaaacaaaa caaaaacaaa                                                   20


<210>  4514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4514
uugcaaggaa gcaugaaauu                                                   20


<210>  4515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4515
uauaggagca gugacuaaua                                                   20


<210>  4516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4516
uuuuucaugu uuuaaaggag                                                   20


<210>  4517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4517
uccuuuaaaa caugaaaaag                                                   20


<210>  4518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4518
caggaaccug caggaggcac                                                   20


<210>  4519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4519
cucagaaauu ugcauauuua                                                   20


<210>  4520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4520
cagguugucc aagaaaggga                                                   20


<210>  4521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4521
aaaugcuucu gaauuuuauu                                                   20


<210>  4522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4522
gguuaauaug ugaaauaaau                                                   20


<210>  4523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4523
ggaaauuugc uuuuaucuca                                                   20


<210>  4524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4524
caaacccuuu aaagaugcau                                                   20


<210>  4525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4525
uuaaaggguu ugagauaaaa                                                   20


<210>  4526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4526
cuauguaaca ugcaucuuua                                                   20


<210>  4527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4527
uggugaguuu uuuuuuuuuu                                                   20


<210>  4528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4528
caaacaccau uuucaaagaa                                                   20


<210>  4529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4529
uuagguaacc ucuaggaaau                                                   20


<210>  4530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4530
auuaaaggaa aauuuuguga                                                   20


<210>  4531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4531
aaauguccag ucuacacuau                                                   20


<210>  4532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4532
gauggccaua gcucuauagu                                                   20


<210>  4533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4533
gauuucaaug ugccuaacuu                                                   20


<210>  4534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4534
guaauagagu gacuauagag                                                   20


<210>  4535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4535
uaauaugaaa aucuguaaua                                                   20


<210>  4536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4536
uauuauucug uucugucagc                                                   20


<210>  4537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4537
caggucugaa uuauaucaua                                                   20


<210>  4538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4538
aauggguuga ggaggagucc                                                   20


<210>  4539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4539
gagcaaggac uccuccucaa                                                   20


<210>  4540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4540
aaucacaaaa acuguuaaaa                                                   20


<210>  4541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4541
caaaaacugu uaaaacuugu                                                   20


<210>  4542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4542
caucaaauca cauacacuuu                                                   20


<210>  4543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4543
aaucacauac acuuuuauug                                                   20


<210>  4544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4544
cauacacuuu uauugaaauu                                                   20


<210>  4545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4545
auuucaacuu uagaauuuaa                                                   20


<210>  4546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4546
agaguuuuua auguacaccu                                                   20


<210>  4547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4547
aggcuugccu ugguggcuca                                                   20


<210>  4548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4548
uccccaaggc cccacacucc                                                   20


<210>  4549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4549
guuuuaggaa uauaagcucu                                                   20


<210>  4550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4550
caccguggcu acauacugaa                                                   20


<210>  4551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4551
gaauauggaa aagaaguaca                                                   20


<210>  4552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4552
uuacagcuac agcaaagugg                                                   20


<210>  4553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4553
gcaccaucca ggaaucuugu                                                   20


<210>  4554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4554
aggaaucuug uauccugugu                                                   20


<210>  4555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4555
uguauccugu guguugagcu                                                   20


<210>  4556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4556
uguguguuga gcucugaccu                                                   20


<210>  4557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4557
accaguuucu cucccuuucu                                                   20


<210>  4558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4558
auuucuaauu aguucugccu                                                   20


<210>  4559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4559
cgauauuaau gguaccaacc                                                   20


<210>  4560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4560
ggaucuauuu cuaauuaguu                                                   20


<210>  4561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4561
cucuauauga ucaggagaau                                                   20


<210>  4562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4562
uauagaguga ugggugcuug                                                   20


<210>  4563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4563
ggagaauuuu uaaaccccua                                                   20


<210>  4564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4564
auugaaucaa gagacuguuu                                                   20


<210>  4565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4565
agagacuguu ugaucuuauc                                                   20


<210>  4566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4566
aacagucucu ugauucaaua                                                   20


<210>  4567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4567
uaucugcauc ugugagcuga                                                   20


<210>  4568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4568
gcaucuguga gcugacuguc                                                   20


<210>  4569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4569
gugagcugac ugucaaccug                                                   20


<210>  4570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4570
ucuauaguag cuguaucaag                                                   20


<210>  4571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4571
auaguagcug uaucaagcug                                                   20


<210>  4572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4572
agcugggaug aucuguuaau                                                   20


<210>  4573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4573
cagcuugaua cagcuacuau                                                   20


<210>  4574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4574
ucccagcuug auacagcuac                                                   20


<210>  4575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4575
guuaauucua aauuuauuaa                                                   20


<210>  4576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4576
uguuuaaucu aguguagccc                                                   20


<210>  4577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4577
aguguagccc gcauuuauuu                                                   20


<210>  4578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4578
uucuuuaaga uauggcugug                                                   20


<210>  4579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4579
uaaagaagga uuuagucuug                                                   20


<210>  4580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4580
uaaugaaacc cacauuagcu                                                   20


<210>  4581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4581
auagccuguu aggguagcca                                                   20


<210>  4582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4582
gacauccaua gccuguuagg                                                   20


<210>  4583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4583
caggcacucu ccuaggcuga                                                   20


<210>  4584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4584
guuagaggac uccuucccuu                                                   20


<210>  4585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4585
gucuuucugg cuuuggacca                                                   20


<210>  4586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4586
auaaggauca gcuauugcug                                                   20


<210>  4587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4587
uuauugauuc agaaguuuga                                                   20


<210>  4588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4588
gcuauugcug gaaugaauga                                                   20


<210>  4589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4589
uucauuccag caauagcuga                                                   20


<210>  4590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4590
gaagacagac uaacauauua                                                   20


<210>  4591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4591
uuuuuuuauc ugaagacaga                                                   20


<210>  4592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4592
aucucuucua cuugcccauu                                                   20


<210>  4593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4593
cuucuacuug cccauuacug                                                   20


<210>  4594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4594
guaaugggca aguagaagag                                                   20


<210>  4595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4595
acauauucau agcuuuucuu                                                   20


<210>  4596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4596
ggcacguggu uaccaaaaaa                                                   20


<210>  4597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4597
cucuaaugua gccuaauaac                                                   20


<210>  4598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4598
gaaugcuaaa auuguuauua                                                   20


<210>  4599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4599
cuucaucuga augcuaaaau                                                   20


<210>  4600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4600
aauagaaaag gcagucacag                                                   20


<210>  4601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4601
aaucuaauag aaaaggcagu                                                   20


<210>  4602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4602
cugccucgaa ggcacccacu                                                   20


<210>  4603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4603
aucugugagg cugcuaccga                                                   20


<210>  4604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4604
gugaggcugc uaccgacuca                                                   20


<210>  4605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4605
ggugccagcc ugcuuuccac                                                   20


<210>  4606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4606
auguugacua ugaagcaaaa                                                   20


<210>  4607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4607
aggcagaacg gagcgccucg                                                   20


<210>  4608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4608
uuuccauaua cugaaaugug                                                   20


<210>  4609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4609
agccucuuau gcaaucauaa                                                   20


<210>  4610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4610
uaaaucuaca uaggagucuu                                                   20


<210>  4611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4611
acauaggagu cuugugauuu                                                   20


<210>  4612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4612
caagacuccu auguagauuu                                                   20


<210>  4613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4613
aaucacaaga cuccuaugua                                                   20


<210>  4614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4614
uuggagguga augaaauauc                                                   20


<210>  4615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4615
cuguugggag ggagaaaaaa                                                   20


<210>  4616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4616
agcuuccugc uugcugaaug                                                   20


<210>  4617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4617
uucagcaagc aggaagcuug                                                   20


<210>  4618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4618
aggauuugug ugugugugug                                                   20


<210>  4619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4619
uagauaaaag ccagugaguu                                                   20


<210>  4620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4620
accaaagcaa cggauaguau                                                   20


<210>  4621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4621
guugcuuugg uagauuuuua                                                   20


<210>  4622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4622
aagauaccaa aaucaaaucu                                                   20


<210>  4623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4623
uugauacuau ccguugcuuu                                                   20


<210>  4624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4624
aaucugacuu gaauauccua                                                   20


<210>  4625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4625
gacuugaaua uccuacaucu                                                   20


<210>  4626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4626
uacaucucca cacccauccu                                                   20


<210>  4627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4627
ccacacccau ccucauuaug                                                   20


<210>  4628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4628
ucauuaugca uuucuagaua                                                   20


<210>  4629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4629
agaaaugcau aaugaggaug                                                   20


<210>  4630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4630
aucuagaaau gcauaaugag                                                   20


<210>  4631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4631
cugaauucug accccuuuuu                                                   20


<210>  4632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4632
agaggggaga gauaaagagg                                                   20


<210>  4633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4633
cuccccucuu gaugguuaaa                                                   20


<210>  4634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4634
guuucucucu ccucuguguc                                                   20


<210>  4635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4635
uuaccucucu cuguuuggca                                                   20


<210>  4636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4636
gcuucucucc ucccuaggcc                                                   20


<210>  4637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4637
ggagaaggag acguucgugu                                                   20


<210>  4638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4638
cccacuagag uacacagaug                                                   20


<210>  4639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4639
guguacucua gugggugauc                                                   20


<210>  4640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4640
ggggcugggu gguaaagagg                                                   20


<210>  4641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4641
gcacucaaca cuuugucauu                                                   20


<210>  4642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4642
ugccccaucc ucuccaucgc                                                   20


<210>  4643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4643
ucuccaucgc ucccaaccac                                                   20


<210>  4644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4644
cucccaacca ccgcgcgccc                                                   20


<210>  4645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4645
ggucuacgac gauuuuuucc                                                   20


<210>  4646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4646
ucguagaccg gauguuucca                                                   20


<210>  4647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4647
ggcaguauuu gcugcccugc                                                   20


<210>  4648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4648
gaggcagggc agcaaauacu                                                   20


<210>  4649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4649
gagacaagag gcgcccagga                                                   20


<210>  4650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4650
ugggcgccuc uugucucaga                                                   20


<210>  4651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4651
ccaggauggg aaccucaagc                                                   20


<210>  4652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4652
uggggauuac augagcucau                                                   20


<210>  4653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4653
uaaggggcuu gagguuccca                                                   20


<210>  4654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4654
uggucuuuuu cuuuuuucuu                                                   20


<210>  4655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4655
gaagcaacuu gugccaugca                                                   20


<210>  4656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4656
agcgcucucc auggcacugc                                                   20


<210>  4657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4657
acguggguuu gcagguuccu                                                   20


<210>  4658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4658
gcaauuacuu uggauauuuc                                                   20


<210>  4659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4659
aaaguaauug cagauugcgg                                                   20


<210>  4660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4660
gggagggagu ggaagaaacu                                                   20


<210>  4661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4661
uacuugagau cucuaaucuu                                                   20


<210>  4662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4662
caaguaggau cugggaggga                                                   20


<210>  4663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4663
cuaaucuuuc aacuuggguc                                                   20


<210>  4664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4664
uucaacuugg gucucuguuu                                                   20


<210>  4665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4665
aagagaaaga aaaaaaaaga                                                   20


<210>  4666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4666
aggaacaaua ggcauguaaa                                                   20


<210>  4667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4667
cccuauaaag cucagaaccu                                                   20


<210>  4668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4668
uccuuuaaua aaauuaauua                                                   20


<210>  4669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4669
guuuaugcaa uaugacagcc                                                   20


<210>  4670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4670
cuggugacuc aacagcgucu                                                   20


<210>  4671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4671
ucacaucaua agcuuauacu                                                   20


<210>  4672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4672
uaagcuuaua cuuccugccc                                                   20


<210>  4673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4673
aauggggcag gaaguauaag                                                   20


<210>  4674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4674
ugggcggcac cgugauccgg                                                   20


<210>  4675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4675
cggugccgcc caggaucaaa                                                   20


<210>  4676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4676
gggucugguu uuuguuugac                                                   20


<210>  4677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4677
cgggguucug cacaauugga                                                   20


<210>  4678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4678
guauauuccc auugccagac                                                   20


<210>  4679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4679
uagaguggau auuuucuuga                                                   20


<210>  4680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4680
acucuaggau gcaccggagg                                                   20


<210>  4681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4681
gcuuagaaau cacauucuau                                                   20


<210>  4682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4682
cauucuauga aauccaauau                                                   20


<210>  4683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4683
aauaugccuu cucaagagcg                                                   20


<210>  4684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4684
cuguguauuc cuuaauugcc                                                   20


<210>  4685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4685
ccuaggaauu cuaaugucau                                                   20


<210>  4686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4686
ccuuggauuu uguucaacau                                                   20


<210>  4687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4687
aaggugauaa uauaaaaaaa                                                   20


<210>  4688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4688
auguugaaca aaauccaagg                                                   20


<210>  4689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4689
agaaacguau agcauaugua                                                   20


<210>  4690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4690
auuucuauac auaugcuaua                                                   20


<210>  4691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4691
uaucuauuuc uauacauaug                                                   20


<210>  4692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4692
aaacaaauuc cauaaaagag                                                   20


<210>  4693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4693
aaaucaaaac aaauuccaua                                                   20


<210>  4694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4694
auagauagua aaaagaauga                                                   20


<210>  4695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4695
auagaucuaa aucaaaacaa                                                   20


<210>  4696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4696
aagauguuua ucacuuuaau                                                   20


<210>  4697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4697
uagauucagu guaauucaca                                                   20


<210>  4698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4698
cuuuaauauu acacuuccua                                                   20


<210>  4699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4699
gaaaguuugg ggacuauucc                                                   20


<210>  4700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4700
uauguuccuc uccaaaccug                                                   20


<210>  4701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4701
acacuucaca uaaaauguuu                                                   20


<210>  4702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4702
caaaaauauu ugucucuaac                                                   20


<210>  4703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4703
ugaaacagau ucucccagcu                                                   20


<210>  4704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4704
guuucaagau guuugcuuuu                                                   20


<210>  4705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4705
cuaauucuca gacugcucuc                                                   20


<210>  4706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4706
gagagcaguc ugagaauuag                                                   20


<210>  4707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4707
guguaaguuc cccaauucuc                                                   20


<210>  4708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4708
guacaauaug uuuuuaaaac                                                   20


<210>  4709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4709
ccaucugcuc aaauggggga                                                   20


<210>  4710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4710
gcucaaaugg gggaaaacca                                                   20


<210>  4711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4711
uaaaaaaaaa agaggugaga                                                   20


<210>  4712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4712
aaagauucag guucuagugc                                                   20


<210>  4713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4713
uuugauagaa ccuauguaag                                                   20


<210>  4714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4714
gcuuagcuuu guuuaucagg                                                   20


<210>  4715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4715
ggacucuaag ucccuggguu                                                   20


<210>  4716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4716
acccagggac uuagaguccu                                                   20


<210>  4717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4717
uaucaaccca gggacuuaga                                                   20


<210>  4718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4718
ucugggagug gggagaaaag                                                   20


<210>  4719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4719
aauagauaaa uagauacaaa                                                   20


<210>  4720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4720
auuugauagu ugugcuuuuc                                                   20


<210>  4721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4721
auuuaucuau uugauaguug                                                   20


<210>  4722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4722
caauucuuug uaucuauuua                                                   20


<210>  4723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4723
uaucuuuuug ugggaaagaa                                                   20


<210>  4724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4724
uuuuguggga aagaaaguag                                                   20


<210>  4725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4725
accuaccuac uuucuuuccc                                                   20


<210>  4726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4726
gccauucagg gcuauugaaa                                                   20


<210>  4727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4727
acaacugcuu ucaauagccc                                                   20


<210>  4728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4728
aggacccagu ggaacuuacu                                                   20


<210>  4729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4729
guauucugcu guuucuucug                                                   20


<210>  4730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4730
ucuaggaugu accaaguugu                                                   20


<210>  4731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4731
aggauguacc aaguuguaag                                                   20


<210>  4732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4732
uagaugaucu guauucugcu                                                   20


<210>  4733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4733
uuacaacuug guacauccua                                                   20


<210>  4734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4734
ucauugcuug aauccuuaca                                                   20


<210>  4735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4735
ucuucauugc uugaauccuu                                                   20


<210>  4736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4736
ucuauuacac ccccuguacc                                                   20


<210>  4737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4737
gauggagagg caaauguacu                                                   20


<210>  4738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4738
gaucuucuau uacacccccu                                                   20


<210>  4739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4739
uaggcuucca caugacagau                                                   20


<210>  4740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4740
gucaugugga agccuaggau                                                   20


<210>  4741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4741
acuuguuuua ucugucaugu                                                   20


<210>  4742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4742
uaaaaauaaa gaaauucaau                                                   20


<210>  4743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4743
cagaauaaua ugauguauuu                                                   20


<210>  4744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4744
uauuauucug ugauuaauag                                                   20


<210>  4745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4745
ucuccucccu ggacagucag                                                   20


<210>  4746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4746
uggugccaau gucuguuuau                                                   20


<210>  4747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4747
aaaagccaga aauuuguaag                                                   20


<210>  4748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4748
cccuuugcca gggggaggga                                                   20


<210>  4749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4749
uuuggcucac ucuucccucc                                                   20


<210>  4750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4750
ccgucacugu ucaguuucag                                                   20


<210>  4751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4751
uuccaggggc cugggaauuu                                                   20


<210>  4752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4752
uguuggaguu ggguagaaga                                                   20


<210>  4753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4753
gcugcucucu uucuacucaa                                                   20


<210>  4754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4754
aaacaaaagu agcagcugcc                                                   20


<210>  4755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4755
cucuaaacuu auagaauauu                                                   20


<210>  4756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4756
gaaaacugug ucacauguug                                                   20


<210>  4757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4757
ugccugaugu agcugaagca                                                   20


<210>  4758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4758
ggcaagaugc agcccccaaa                                                   20


<210>  4759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4759
uccugucacu ccacugugcu                                                   20


<210>  4760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4760
cuaggcaaag gaaaaccauu                                                   20


<210>  4761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4761
uuucauuugc auaugggcca                                                   20


<210>  4762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4762
ucucuuucau aauugacgau                                                   20


<210>  4763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4763
ucaauuauga aagagaagau                                                   20


<210>  4764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4764
ucgucaauua ugaaagagaa                                                   20


<210>  4765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4765
gaagcaucau cgucaauuau                                                   20


<210>  4766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4766
ccaucagaag caucaucguc                                                   20


<210>  4767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4767
uguguaugua aauagaaauc                                                   20


<210>  4768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4768
ucucauagaa agucuacucu                                                   20


<210>  4769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4769
uucccugugg gggccccaaa                                                   20


<210>  4770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4770
cucuucucca ccucuaggaa                                                   20


<210>  4771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4771
ucaaguguuu cuuccuagag                                                   20


<210>  4772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4772
cauucauuca gcauccacua                                                   20


<210>  4773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4773
acuauaugca caaccuuuug                                                   20


<210>  4774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4774
ucuuuuaaaa aaugaaccca                                                   20


<210>  4775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4775
cuauuugggu ucauuuuuua                                                   20


<210>  4776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4776
uuguuuucuc aauaucucua                                                   20


<210>  4777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4777
aaugaaagag uaacaauugc                                                   20


<210>  4778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4778
guuaaccggu uggaugguga                                                   20


<210>  4779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4779
aaccgguuaa cagauagcaa                                                   20


<210>  4780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4780
cuggugcaau aaagcuaagu                                                   20


<210>  4781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4781
uuuaaaauua gauucuguuu                                                   20


<210>  4782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4782
aauuuuaaag gauuuuuaau                                                   20


<210>  4783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4783
aguagaaaau aacaguauga                                                   20


<210>  4784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4784
ucauaagggc ugccagcauu                                                   20


<210>  4785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4785
uguaucuugg cugcuaaaau                                                   20


<210>  4786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4786
uggcugcuaa aaucacugca                                                   20


<210>  4787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4787
cugcaggcug aaucuuguca                                                   20


<210>  4788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4788
ugucauacag gaggagauuu                                                   20


<210>  4789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4789
ccuccuguau gacaagauuc                                                   20


<210>  4790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4790
ugcuccaugc ccuggacuga                                                   20


<210>  4791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4791
cagcuaaggu gugcuaagaa                                                   20


<210>  4792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4792
cagaucggaa cccaguucuc                                                   20


<210>  4793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4793
gggaucacag cuaaggugug                                                   20


<210>  4794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4794
gaacccaguu cucuugagaa                                                   20


<210>  4795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4795
aguaacucaa aaauuucucu                                                   20


<210>  4796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4796
uguaagagaa auuuuugagu                                                   20


<210>  4797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4797
cacauaaaua uauauuuuaa                                                   20


<210>  4798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4798
auuguaaaca uacagcagaa                                                   20


<210>  4799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4799
cuuaauaaga augagcaaaa                                                   20


<210>  4800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4800
aguuauauaa acacacauuc                                                   20


<210>  4801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4801
gcaaauauua uguaauacau                                                   20


<210>  4802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4802
acuuugauau caaaauugaa                                                   20


<210>  4803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4803
aaguggaugu acuguauauu                                                   20


<210>  4804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4804
aaauugaaca ccuauggucu                                                   20


<210>  4805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4805
gacuuaaauu cuuacuucca                                                   20


<210>  4806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4806
aacaguaaaa gcuuucaugu                                                   20


<210>  4807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4807
gccuucacuu uaucuguuua                                                   20


<210>  4808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4808
guuuagggua uuauuuuaau                                                   20


<210>  4809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4809
auauaccaau uuacauuaaa                                                   20


<210>  4810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4810
uauccauaua ccaauuuaca                                                   20


<210>  4811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4811
cagaaauaua gcuauuuaug                                                   20


<210>  4812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4812
ucuuuugcua gcuguacuuu                                                   20


<210>  4813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4813
cuuuuuaguu gaacuagaag                                                   20


<210>  4814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4814
uuggcaaaaa uuaaaaagua                                                   20


<210>  4815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4815
acuuaaaaug uaaaagcauc                                                   20


<210>  4816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4816
cuaucuaaga aacaaguuua                                                   20


<210>  4817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4817
aagaaacaag uuuaauaguu                                                   20


<210>  4818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4818
cacucaaauu gccauauacu                                                   20


<210>  4819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4819
aaugguuuau uuauuaauaa                                                   20


<210>  4820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4820
auguuucugc uuaauaaacu                                                   20


<210>  4821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4821
aguuuauuaa gcagaaacau                                                   20


<210>  4822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4822
aagggaaaau uagaaagugu                                                   20


<210>  4823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4823
aauuauguau uuauuuuguc                                                   20


<210>  4824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4824
gaaaccaagu uuccuuuugc                                                   20


<210>  4825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4825
guaauaucug aaaccaaguu                                                   20


<210>  4826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4826
cuuugguguc uaaucuguaa                                                   20


<210>  4827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4827
auuuccauuu guguuuauaa                                                   20


<210>  4828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4828
acuauguucu uauaaacaca                                                   20


<210>  4829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4829
gugcuggagg uaagggagcc                                                   20


<210>  4830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4830
gcucaaaggc ccuggauucu                                                   20


<210>  4831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4831
agggccuuug agcugauacc                                                   20


<210>  4832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4832
aaccgcugcc cuaaagccag                                                   20


<210>  4833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4833
uggggccagg cuaaccccug                                                   20


<210>  4834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4834
cuacagaaga aaucacauaa                                                   20


<210>  4835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4835
cauaaacugg ccugcgguug                                                   20


<210>  4836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4836
aagcccccca accgcaggcc                                                   20


<210>  4837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4837
ucuaagcccc ccaaccgcag                                                   20


<210>  4838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4838
caugauaugc uguucccuga                                                   20


<210>  4839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4839
ugagaugggg aaggucaauu                                                   20


<210>  4840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4840
uaaguaguuu caacuaagca                                                   20


<210>  4841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4841
agaguucuca ugaggaacau                                                   20


<210>  4842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4842
gaaauguugc aggcuucugg                                                   20


<210>  4843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4843
ccagaagccu gcaacauuuc                                                   20


<210>  4844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4844
uccuuuuauu cugcacugcu                                                   20


<210>  4845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4845
uuuaaggcuu auagguaauu                                                   20


<210>  4846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4846
uaauuaccua uaagccuuaa                                                   20


<210>  4847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4847
cagcacuuug ggaggccgag                                                   20


<210>  4848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4848
cuuuucacau ugauuuuggc                                                   20


<210>  4849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4849
augugaaaag agaugaaagu                                                   20


<210>  4850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4850
guuagaagaa aaacaacaga                                                   20


<210>  4851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4851
cccuagcaug uuugcacaau                                                   20


<210>  4852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4852
gaccuuaaca uuccaagcuu                                                   20


<210>  4853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4853
ugcaagcgaa uucucucaaa                                                   20


<210>  4854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4854
ucuuggagag uuuauguuuc                                                   20


<210>  4855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4855
uuuuguaaaa cagaaauccu                                                   20


<210>  4856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4856
auucuucgca uaaauaagag                                                   20


<210>  4857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4857
caaguccuau uucugccucc                                                   20


<210>  4858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4858
uuggcaucaa aaagcaacuu                                                   20


<210>  4859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4859
aaaagcaacu uucgagugag                                                   20


<210>  4860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4860
uuuccucccc ucucacucga                                                   20


<210>  4861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4861
aaauauugag cccuaccaac                                                   20


<210>  4862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4862
ggaagguugc uuuacauacc                                                   20


<210>  4863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4863
caaugucuau uuaaaugugc                                                   20


<210>  4864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4864
augaauguuu acuucaauga                                                   20


<210>  4865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4865
cucugcccga gucagucagu                                                   20


<210>  4866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4866
agcccacaca gugucuuugc                                                   20


<210>  4867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4867
ccuuuugaca gucauucuua                                                   20


<210>  4868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4868
cacaccuacu aaauuuucau                                                   20


<210>  4869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4869
auuucaggca uaaauggauu                                                   20


<210>  4870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4870
auuuaugccu gaaauagaua                                                   20


<210>  4871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4871
ccacacugaa auguuucaac                                                   20


<210>  4872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4872
ggaagcacag aucggauuuu                                                   20


<210>  4873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4873
gugcuuccag aucuccacac                                                   20


<210>  4874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4874
gauuuuggag cugaccuggg                                                   20


<210>  4875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4875
caguuuuuuc aauuauugua                                                   20


<210>  4876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4876
uugaaaagua uuaccaaauc                                                   20


<210>  4877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4877
caugcuaggg cacauucaau                                                   20


<210>  4878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4878
aggucuuaaa ccacuguuca                                                   20


<210>  4879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4879
cacauaugua gaauguuaaa                                                   20


<210>  4880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4880
uaaaaucccu gcuaaagcag                                                   20


<210>  4881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4881
cugcuaaagc agggccugcu                                                   20


<210>  4882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4882
caagcuuuag uaguucagac                                                   20


<210>  4883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4883
gucugaacua cuaaagcuug                                                   20


<210>  4884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4884
accuauuaau auuaauuguc                                                   20


<210>  4885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4885
cacgggagau gggugggcac                                                   20


<210>  4886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4886
cccgugugau aaugccacau                                                   20


<210>  4887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4887
ggguuuuggc agguauuaga                                                   20


<210>  4888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4888
aauaccugcc aaaacccaga                                                   20


<210>  4889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4889
aagggauuac uuggcucagg                                                   20


<210>  4890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4890
cuuugauuac aucuaauacc                                                   20


<210>  4891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4891
ccaggggaaa agaaacaaaa                                                   20


<210>  4892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4892
cuuuuuguuu uuguuucuuu                                                   20


<210>  4893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4893
aucucuuuuu guuuuuguuu                                                   20


<210>  4894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4894
uugugggcug uccauccauc                                                   20


<210>  4895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4895
uauugcccua cagcugaggu                                                   20


<210>  4896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4896
agaaauagac cuguaagugc                                                   20


<210>  4897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4897
ggguucuggu accucaagaa                                                   20


<210>  4898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4898
ucaggguucu gguaccucaa                                                   20


<210>  4899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4899
gagcaaaagu ugaacauaaa                                                   20


<210>  4900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4900
ucagagcaaa aguugaacau                                                   20


<210>  4901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4901
ugugccuguu acacccgaaa                                                   20


<210>  4902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4902
augcuguaug ugaaucuuua                                                   20


<210>  4903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4903
uuauaaaauu uuacugucaa                                                   20


<210>  4904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4904
ggccuccccc gcggggcggu                                                   20


<210>  4905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4905
ugcggccuga gcuggacacu                                                   20


<210>  4906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4906
ugguauuuuu auucauugua                                                   20


<210>  4907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4907
agaauauuua gugauguagu                                                   20


<210>  4908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4908
cuaaauauuc uugaucaugg                                                   20


<210>  4909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4909
ggaacgucac aaaggaaagu                                                   20


<210>  4910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4910
auucuaacuu gguacauggc                                                   20


<210>  4911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4911
aggcucuggu aauuggaagu                                                   20


<210>  4912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4912
acaacaaggc ccaacucugu                                                   20


<210>  4913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4913
ggagagacuc uuuaagcacc                                                   20


<210>  4914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4914
uaaagaagac gugaucugca                                                   20


<210>  4915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4915
cgucuucuuu augaucagga                                                   20


<210>  4916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4916
gcaugccaaa uggaaaaagc                                                   20


<210>  4917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4917
gauuugggga gcaggagagc                                                   20


<210>  4918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4918
gaugcuuugc uccaagcagg                                                   20


<210>  4919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4919
uuggcuccug acacggccaa                                                   20


<210>  4920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4920
uccaguuccu uaacuacccc                                                   20


<210>  4921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4921
ucucuuuuga ggggagagaa                                                   20


<210>  4922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4922
agagugcaaa gggcuucccc                                                   20


<210>  4923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4923
ccaucgagag ugcaaagggc                                                   20


<210>  4924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4924
augaagcuuc ucagccuugc                                                   20


<210>  4925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4925
cuccgccgcg ggacugguuu                                                   20


<210>  4926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4926
uaagagcuau uuuagaaaac                                                   20


<210>  4927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4927
gccuugagcu caccucuggg                                                   20


<210>  4928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4928
aucagccuug agcucaccuc                                                   20


<210>  4929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4929
gcagccuuug gaagggacag                                                   20


<210>  4930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4930
auuugcacac cgcucccucu                                                   20


<210>  4931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4931
ccuccaaauc aauuugcaca                                                   20


<210>  4932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4932
auggcucggg gcgcggcccc                                                   20


<210>  4933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4933
gugacacggc agcgagccgg                                                   20


<210>  4934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4934
ucuccaaauc gauucacaca                                                   20


<210>  4935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4935
auucacacac cauuccuccu                                                   20


<210>  4936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4936
auuuggagag gaucagugac                                                   20


<210>  4937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4937
gacauggcag gugugcugag                                                   20


<210>  4938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4938
guuucucuga cuccuugccu                                                   20


<210>  4939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4939
caucuguuuc ucugacuccu                                                   20


<210>  4940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4940
ucauaccucu cucugacucu                                                   20


<210>  4941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4941
gcuggcucug aagaguccac                                                   20


<210>  4942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4942
uaauauauuu cucuuuauac                                                   20


<210>  4943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4943
uucaaaaacc ggcauuuuua                                                   20


<210>  4944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4944
ugagggaaac cauuucugug                                                   20


<210>  4945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4945
ucaguuauaa auaggaaaca                                                   20


<210>  4946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4946
uccagggagc uuuucaaaga                                                   20


<210>  4947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4947
agaaaucuuc cagggagcuu                                                   20


<210>  4948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4948
acuaaaaguu uuuaacgauc                                                   20


<210>  4949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4949
uuaaaaacuu uuaguugauu                                                   20


<210>  4950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4950
uuuaauccug cuuuugucug                                                   20


<210>  4951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4951
ugcuuuuguc ugcucuugag                                                   20


<210>  4952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4952
agauucuucc acaggcagag                                                   20


<210>  4953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4953
ugauuucagu ggcucaagag                                                   20


<210>  4954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4954
cuuugguucu cugccugugg                                                   20


<210>  4955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4955
cuucucauuu guaaaaggga                                                   20


<210>  4956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4956
acccacaacc cacagagaga                                                   20


<210>  4957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4957
uuaaacauuu gcaagagcaa                                                   20


<210>  4958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4958
gcaggggcuu guucaucuuu                                                   20


<210>  4959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4959
cauucaucau gaacacuuca                                                   20


<210>  4960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4960
ugaacacuuc aauucuauca                                                   20


<210>  4961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4961
gaccuucaug gcccuucuca                                                   20


<210>  4962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4962
ugauaaaccc auugcaagua                                                   20


<210>  4963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4963
ggauguaacc cuauuuuaug                                                   20


<210>  4964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4964
uaaaucaaaa augcgucuaa                                                   20


<210>  4965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4965
aaaaugcguc uaauauaccu                                                   20


<210>  4966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4966
gugagcuaua aaaugggugc                                                   20


<210>  4967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4967
gcaauaauau cugugagcua                                                   20


<210>  4968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4968
gcugacucau uucacuggug                                                   20


<210>  4969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4969
uacauuccac agaggugaca                                                   20


<210>  4970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4970
uugaaggcug acaaucuguc                                                   20


<210>  4971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4971
gucugguuca uugcuauucu                                                   20


<210>  4972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4972
aagaaaaacc caggaccuga                                                   20


<210>  4973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4973
gguccugggu uuuucuucga                                                   20


<210>  4974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4974
aaauuggaaa gaaagaaguc                                                   20


<210>  4975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4975
uguugucugu gaaaaaggcu                                                   20


<210>  4976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4976
uauacuuaga aaugccuaaa                                                   20


<210>  4977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4977
guucuaacaa uuuuuuggug                                                   20


<210>  4978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4978
auuuaucagu ucuaacaauu                                                   20


<210>  4979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4979
ugcaacuuua cugaauccau                                                   20


<210>  4980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4980
guuggccauu uguauauauu                                                   20


<210>  4981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4981
cucaucauca uaaucagaga                                                   20


<210>  4982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4982
ucauaaucag agaaaugcaa                                                   20


<210>  4983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4983
uaaucagaga aaugcaaauc                                                   20


<210>  4984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4984
gagaaaugca aaucaaaacc                                                   20


<210>  4985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4985
aaaccauaau gagauaucau                                                   20


<210>  4986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4986
cauuaugguu uugauuugca                                                   20


<210>  4987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4987
uccaugucac cccaguuaaa                                                   20


<210>  4988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4988
augucacccc aguuaaaaug                                                   20


<210>  4989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4989
aaaagacagg gaauaaugga                                                   20


<210>  4990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4990
auuauucccu gucuuuuuga                                                   20


<210>  4991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4991
uagccagcau ccauuauucc                                                   20


<210>  4992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4992
ggugcgggca ccauucagaa                                                   20


<210>  4993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4993
cauagccuug ucugaaaugu                                                   20


<210>  4994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4994
ucauggcuca aaguucuuca                                                   20


<210>  4995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4995
uggcucaaag uucuucaaaa                                                   20


<210>  4996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4996
acagcugugu cucagagacc                                                   20


<210>  4997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4997
gauauccccc ucaugccuuu                                                   20


<210>  4998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4998
gauccacagc ugugucucag                                                   20


<210>  4999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  4999
cccucaugcc uuugacaucu                                                   20


<210>  5000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5000
gagcaagaga uauuggagcu                                                   20


<210>  5001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5001
cuugcucaga ugucaaaggc                                                   20


<210>  5002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5002
uuuugugaca ggggagucau                                                   20


<210>  5003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5003
cuugcucuga aauuuaucug                                                   20


<210>  5004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5004
gaagucaaaa ggaguggguu                                                   20


<210>  5005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5005
agaaguuuga uggccgagag                                                   20


<210>  5006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5006
uuaggucaca uagaccuucu                                                   20


<210>  5007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5007
uuguucuuug aaagaaaaac                                                   20


<210>  5008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5008
ugcagacagc cccagggguc                                                   20


<210>  5009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5009
ugaccccugg ggcugucugc                                                   20


<210>  5010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5010
augauuagug aauuagugac                                                   20


<210>  5011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5011
uugauuaacu uuauauccug                                                   20


<210>  5012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5012
ugcauggaga aagaaaagga                                                   20


<210>  5013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5013
aguguuuauu uuacuuauuu                                                   20


<210>  5014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5014
ucaaguguuu auuuuacuua                                                   20


<210>  5015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5015
uaucacacag gcuugguuac                                                   20


<210>  5016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5016
cacaggcuug guuacagaaa                                                   20


<210>  5017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5017
gaaucuacac ugggguccac                                                   20


<210>  5018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5018
acacuggggu ccacaaacag                                                   20


<210>  5019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5019
acaaugaccu uauuuccaaa                                                   20


<210>  5020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5020
cuucaaacuc ucugcuaguu                                                   20


<210>  5021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5021
gcagggcugg uuccuucuga                                                   20


<210>  5022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5022
agguaucagc agggcugguu                                                   20


<210>  5023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5023
ugggcuucua gccuccagag                                                   20


<210>  5024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5024
gacucaaaau gugaauaguu                                                   20


<210>  5025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5025
cuaagaaaau uagggcaaaa                                                   20


<210>  5026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5026
uggcuccagu uuugcccuaa                                                   20


<210>  5027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5027
uugagcacgu auauccagga                                                   20


<210>  5028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5028
uguauaggag caugaucuca                                                   20


<210>  5029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5029
ugcuccuaua caugauccuu                                                   20


<210>  5030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5030
caggaaggcu uccaguuuuc                                                   20


<210>  5031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5031
guugcuacuu ccuccuaugc                                                   20


<210>  5032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5032
gcaaugcaua ggaggaagua                                                   20


<210>  5033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5033
uuccugugga auuuggacua                                                   20


<210>  5034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5034
ucaaaauguc aguaacuauu                                                   20


<210>  5035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5035
ccauuuaucc aacuacuagu                                                   20


<210>  5036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5036
aacuacuagu gaccaagcac                                                   20


<210>  5037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5037
ggaaauaugc cuuuuaguca                                                   20


<210>  5038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5038
gaaaucagga aauaugccuu                                                   20


<210>  5039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5039
uagagaauag gagggcugag                                                   20


<210>  5040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5040
uugcagggcu gugugcagca                                                   20


<210>  5041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5041
cuucugagca gaguccugag                                                   20


<210>  5042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5042
uuccaaguag cuggaguaca                                                   20


<210>  5043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5043
caaggugccu uguucuguaa                                                   20


<210>  5044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5044
caaauccaca caagaagcaa                                                   20


<210>  5045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5045
acacaagaag caacaaggac                                                   20


<210>  5046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5046
cucaagguca cccaacuggg                                                   20


<210>  5047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5047
cacugcucgu ggaauaaauu                                                   20


<210>  5048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5048
caugaauuua uuccacgagc                                                   20


<210>  5049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5049
uaggaaacug ccuaucccau                                                   20


<210>  5050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5050
uggaggacua ucuuaggaaa                                                   20


<210>  5051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5051
uguucugcua uugauguccu                                                   20


<210>  5052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5052
auagcagaac augaucaugg                                                   20


<210>  5053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5053
ccuccucuug aaagugggau                                                   20


<210>  5054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5054
cacuuucaag aggaggggau                                                   20


<210>  5055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5055
cggaagaaac gucucauaac                                                   20


<210>  5056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5056
cacggugucu guacaucugg                                                   20


<210>  5057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5057
ucucacggug ucuguacauc                                                   20


<210>  5058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5058
guacaauaag caagauaggg                                                   20


<210>  5059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5059
ugcuuauugu acugaugagu                                                   20


<210>  5060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5060
auuuguuuuu guugagaccu                                                   20


<210>  5061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5061
ccaugcccag cuaauuuuug                                                   20


<210>  5062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5062
cuacugaaaa agaaagacaa                                                   20


<210>  5063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5063
cagcacuuug ggagucugag                                                   20


<210>  5064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5064
cuuuguauga cugucucucc                                                   20


<210>  5065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5065
ucuagcuuaa uggagagaca                                                   20


<210>  5066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5066
uggaagacaa gaauacuccu                                                   20


<210>  5067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5067
cauucaacaa acacuugguc                                                   20


<210>  5068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5068
cuaucaaacu uuuguuugau                                                   20


<210>  5069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5069
aacuuuuguu ugauuaaaaa                                                   20


<210>  5070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5070
aacaaaaguu ugauagagau                                                   20


<210>  5071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5071
uuaaucuagu ucuacuccca                                                   20


<210>  5072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5072
aguucuacuc ccaagaggaa                                                   20


<210>  5073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5073
aaauuccucu ugggaguaga                                                   20


<210>  5074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5074
uucugccucu gcuaguuuug                                                   20


<210>  5075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5075
guggaauuuc uguagaaguu                                                   20


<210>  5076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5076
caguuccgcu uuucaaugaa                                                   20


<210>  5077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5077
gugugcccaa auguaaaagg                                                   20


<210>  5078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5078
acuuucuagg aaucuccagu                                                   20


<210>  5079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5079
ccagucuggc uggggacacu                                                   20


<210>  5080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5080
uaaauaauag uguccccagc                                                   20


<210>  5081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5081
ucuuuuaaaa uaucuuccag                                                   20


<210>  5082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5082
uuuaaaauau cuuccagccu                                                   20


<210>  5083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5083
uccagccucu gcucagguaa                                                   20


<210>  5084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5084
uauccugacc aaccaugaac                                                   20


<210>  5085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5085
ugaccaacca ugaacguauu                                                   20


<210>  5086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5086
caaaagcauu gggaaaauuu                                                   20


<210>  5087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5087
aauuacaggg cagcaaaugu                                                   20


<210>  5088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5088
uccugaauuu cucagcuaaa                                                   20


<210>  5089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5089
uuucuaacgc uucccuuuuu                                                   20


<210>  5090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5090
cuguagccuc uacucuucgg                                                   20


<210>  5091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5091
gcucugacaa gauccagcuc                                                   20


<210>  5092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5092
ugucagagca gauuuucugu                                                   20


<210>  5093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5093
agcucgacaa gauuguguuc                                                   20


<210>  5094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5094
ugucgagcug gaucuuguca                                                   20


<210>  5095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5095
ccaggaacac aaucuugucg                                                   20


<210>  5096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5096
uucccucauu uaucugucau                                                   20


<210>  5097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5097
gucaucucac uuucuagguc                                                   20


<210>  5098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5098
cacuuucuag gucacaucau                                                   20


<210>  5099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5099
uuuccuagca ucuaaagugu                                                   20


<210>  5100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5100
aaaguguugu cuguuuauau                                                   20


<210>  5101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5101
acagguucuu ugaaaacaag                                                   20


<210>  5102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5102
uccggaaaca cagacagccc                                                   20


<210>  5103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5103
cugagggcug ucuguguuuc                                                   20


<210>  5104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5104
uuuuuggggg acacaauuca                                                   20


<210>  5105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5105
auauaaggua acauucugag                                                   20


<210>  5106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5106
cuaauaauau uaguuuccua                                                   20


<210>  5107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5107
ucauuguaaa gcaaagucac                                                   20


<210>  5108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5108
uccuccugcc caccagacuu                                                   20


<210>  5109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5109
acuuauacau aaauauauaa                                                   20


<210>  5110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5110
ucuacuuaua cauaaauaua                                                   20


<210>  5111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5111
cauuuguguc cguauauguu                                                   20


<210>  5112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5112
uaggggcuua acaaauauuu                                                   20


<210>  5113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5113
cauuuguggg ggaucaggaa                                                   20


<210>  5114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5114
cccacaaaug ggauucuaca                                                   20


<210>  5115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5115
ggaagcuucc cagagaccua                                                   20


<210>  5116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5116
auugcacuuu aggucucugg                                                   20


<210>  5117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5117
gauguccucu gauuaaacag                                                   20


<210>  5118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5118
gauauugcuu guuaagguau                                                   20


<210>  5119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5119
gaggacauca gauauugcuu                                                   20


<210>  5120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5120
agguaucugc aggguugguu                                                   20


<210>  5121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5121
gcaggguugg uuccuucuug                                                   20


<210>  5122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5122
gguuuccuuc cuagguauaa                                                   20


<210>  5123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5123
aaguuuuauu auuguuuggg                                                   20


<210>  5124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5124
caccauguuc ccacccuggg                                                   20


<210>  5125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5125
uuauuuuacu acuuucagua                                                   20


<210>  5126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5126
gcuacauauu aagugugaca                                                   20


<210>  5127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5127
cuauugucac acuuaauaug                                                   20


<210>  5128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5128
uaaaauauuu auuugaaacu                                                   20


<210>  5129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5129
cgugaaucau cagaaaauca                                                   20


<210>  5130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5130
ucagaaaauc acaaauauga                                                   20


<210>  5131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5131
gaaaaucaca aauaugaauu                                                   20


<210>  5132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5132
caaauaugaa uuuuaaauaa                                                   20


<210>  5133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5133
uuugauucau ugaauuuuug                                                   20


<210>  5134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5134
aaggauagga auaugaguuc                                                   20


<210>  5135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5135
uguagggcag gaguuaagag                                                   20


<210>  5136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5136
ccugucuuuu auuugccccc                                                   20


<210>  5137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5137
cagagaaagc uuccuagaac                                                   20


<210>  5138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5138
uuuuucaaua auuuuuacuc                                                   20


<210>  5139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5139
cauuuauuuc ucugaacauu                                                   20


<210>  5140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5140
cagagcacau aagcacagac                                                   20


<210>  5141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5141
ggugaccuuu ggaacuuuca                                                   20


<210>  5142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5142
aggaaagugg accacaaacc                                                   20


<210>  5143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5143
ugagaggcau uucuuaagaa                                                   20


<210>  5144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5144
aaaacuaaaa acaaaaccag                                                   20


<210>  5145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5145
uuggaaacuc aaauugacuu                                                   20


<210>  5146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5146
ucauccuugg aaacucaaau                                                   20


<210>  5147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5147
ucuuucuuua gcaaauaugu                                                   20


<210>  5148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5148
gccaguuagu uuuaaauuuc                                                   20


<210>  5149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5149
gguauaugag gagaaaaugc                                                   20


<210>  5150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5150
cuuuuguggu ggugcuuguc                                                   20


<210>  5151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5151
gccuuaacuc uugaauucuu                                                   20


<210>  5152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5152
uaaugcaguu uuaucagccu                                                   20


<210>  5153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5153
caccugccca agugugggag                                                   20


<210>  5154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5154
uucuauuuug agaaaggcaa                                                   20


<210>  5155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5155
gcuucuugga ucucugggag                                                   20


<210>  5156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5156
aagaagcaga uguuagaggg                                                   20


<210>  5157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5157
cugggaggcu cagaaacugg                                                   20


<210>  5158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5158
ccuaagcacc uuuauggaug                                                   20


<210>  5159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5159
auaaaggugc uuaggggauu                                                   20


<210>  5160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5160
uaauucaaga aauuaaucgg                                                   20


<210>  5161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5161
aauacauaua ucuguaggug                                                   20


<210>  5162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5162
guagguguuu uaaagacaau                                                   20


<210>  5163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5163
uccaaaccca ccaucuuccc                                                   20


<210>  5164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5164
ucccaaacca ggccuauuaa                                                   20


<210>  5165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5165
auucugaaac auuguuuguu                                                   20


<210>  5166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5166
cauggcaugu gcagcuaaau                                                   20


<210>  5167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5167
uggaccaaaa gcccaacugg                                                   20


<210>  5168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5168
ccuaaaauga cggcuuccca                                                   20


<210>  5169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5169
gagucugaaa gcugaaggcc                                                   20


<210>  5170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5170
cuaaaauggg gauagcggcc                                                   20


<210>  5171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5171
ccauuuuaga gaugaaggca                                                   20


<210>  5172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5172
augccuucuu uagacaucag                                                   20


<210>  5173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5173
gggagccagg auuggcuuua                                                   20


<210>  5174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5174
uggcucccug augucuaaag                                                   20


<210>  5175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5175
guuuguguuu uaaguccaga                                                   20


<210>  5176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5176
uuucaauugg cuuaaaaauc                                                   20


<210>  5177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5177
ccaaccugau cuucucuacc                                                   20


<210>  5178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5178
gguuggagau uuaaauggaa                                                   20


<210>  5179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5179
ucucuaccaa guuccagagc                                                   20


<210>  5180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5180
uucuauaugu cccaccaggg                                                   20


<210>  5181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5181
accuccacuu cugacuggcu                                                   20


<210>  5182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5182
aauccaccuc cacuucugac                                                   20


<210>  5183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5183
cuauuuccag uccacaucca                                                   20


<210>  5184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5184
uacaaaucau aaaaauaagc                                                   20


<210>  5185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5185
uaaaaauaag caagaucauc                                                   20


<210>  5186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5186
ucuucugguu ucuuccuacu                                                   20


<210>  5187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5187
ucaucagugu caaaaaucca                                                   20


<210>  5188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5188
ucagugucaa aaauccaagg                                                   20


<210>  5189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5189
gugucaaaaa uccaagggga                                                   20


<210>  5190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5190
aaggggaggg aaugggagcu                                                   20


<210>  5191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5191
auuuuagaac auuuuuauua                                                   20


<210>  5192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5192
ccacaaucaa uuuuagaaca                                                   20


<210>  5193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5193
agaauauaua cagaauuccu                                                   20


<210>  5194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5194
ucuuuggaaa aauaauucaa                                                   20


<210>  5195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5195
uuucaugugc uuauuggcca                                                   20


<210>  5196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5196
uucuaaugac uagugguguu                                                   20


<210>  5197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5197
aaaccacaau gagauaccac                                                   20


<210>  5198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5198
cauugugguu uugauuugca                                                   20


<210>  5199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5199
ccagaaaacu cuuuucauuu                                                   20


<210>  5200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5200
aucuccagaa aacucuuuuc                                                   20


<210>  5201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5201
cagcacuuug ggaggccuag                                                   20


<210>  5202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5202
accugccuag gccucccaaa                                                   20


<210>  5203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5203
caugagguca ggaguucgag                                                   20


<210>  5204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5204
cauuccauuu ccuucaauua                                                   20


<210>  5205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5205
caauaaaucc auuucaaaga                                                   20


<210>  5206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5206
auuucaaaga aaacucaggg                                                   20


<210>  5207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5207
cugaguuuuc uuugaaaugg                                                   20


<210>  5208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5208
guucuuuuac uugacuaucc                                                   20


<210>  5209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5209
auauuuguua ugacaguuac                                                   20


<210>  5210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5210
cugccacuaa caaccucuuu                                                   20


<210>  5211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5211
gaauuccuuc aguuuccugc                                                   20


<210>  5212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5212
aaucagaauu ccuucaguuu                                                   20


<210>  5213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5213
uuggcaaagu ugaagauuga                                                   20


<210>  5214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5214
ucaacuuugc caaggaucaa                                                   20


<210>  5215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5215
uccuucucac ucucaaucuu                                                   20


<210>  5216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5216
guggaaagcu gagaaggcug                                                   20


<210>  5217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5217
cauguuauua auuuaacgua                                                   20


<210>  5218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5218
auuauugcca cauugacuaa                                                   20


<210>  5219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5219
cucacucagu gacuuaccca                                                   20


<210>  5220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5220
aaacauagaa aagguacagc                                                   20


<210>  5221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5221
aaacacaucu aaacauagaa                                                   20


<210>  5222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5222
uacugaauac ugcaggcaac                                                   20


<210>  5223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5223
caugcuauac acauuuggag                                                   20


<210>  5224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5224
gcaacauaaa cucuguaccc                                                   20


<210>  5225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5225
cacauaagua gaaucauaua                                                   20


<210>  5226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5226
uauaauaucu guucuucugu                                                   20


<210>  5227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5227
guucuucugu gucugguuua                                                   20


<210>  5228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5228
ucaaacaguu aaacauagaa                                                   20


<210>  5229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5229
gccaccuguu uucuacagcg                                                   20


<210>  5230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5230
cauugugguu uugauuugca                                                   20


<210>  5231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5231
uuucaugugu uuauugguca                                                   20


<210>  5232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5232
ucuuugaaaa acugucuauu                                                   20


<210>  5233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5233
acacacagag cuguucuauu                                                   20


<210>  5234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5234
ggaacaagug cugcauuuug                                                   20


<210>  5235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5235
aaaaaaaaaa aacugaaaag                                                   20


<210>  5236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5236
caggcuaauu uucuuacuaa                                                   20


<210>  5237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5237
gcguuuucca uauccuauua                                                   20


<210>  5238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5238
uauuaaauac aagcuaagca                                                   20


<210>  5239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5239
ugucauggag aaaugcuugc                                                   20


<210>  5240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5240
ccaccggaac caugcugggu                                                   20


<210>  5241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5241
ccaucagcag caacuacaag                                                   20


<210>  5242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5242
gcagcaacua caagaagugg                                                   20


<210>  5243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5243
uauaauuuuu agccacuucu                                                   20


<210>  5244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5244
ugaagauuca gacuugauca                                                   20


<210>  5245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5245
ucaggauggu ugugacauau                                                   20


<210>  5246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5246
agucugaauc uucaggaugg                                                   20


<210>  5247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5247
acacuugaag ggaaugaagc                                                   20


<210>  5248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5248
ugggacgauu uacuccagug                                                   20


<210>  5249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5249
ucccaggaua augguuaccu                                                   20


<210>  5250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5250
gacagagagg aaccuguuuu                                                   20


<210>  5251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5251
cuccaucuga cagagaggaa                                                   20


<210>  5252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5252
aacaaaauga uuuugugucu                                                   20


<210>  5253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5253
uuuuguugga uaaaaguauu                                                   20


<210>  5254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5254
accccaugag gcagcccgug                                                   20


<210>  5255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5255
caaugaaccu guuuucauua                                                   20


<210>  5256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5256
agcaauucuc cugccucagc                                                   20


<210>  5257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5257
cagcaguuug ggaggcugag                                                   20


<210>  5258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5258
cuuuaagaau aaaugcuagc                                                   20


<210>  5259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5259
ccugacauag cugucucauu                                                   20


<210>  5260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5260
gccuacaaag aaagaguguu                                                   20


<210>  5261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5261
ggcccagucu caaacuuggu                                                   20


<210>  5262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5262
ugcaugagga cauuggugau                                                   20


<210>  5263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5263
ccaauguccu caugcaggau                                                   20


<210>  5264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5264
uuucuuauca ccaauguccu                                                   20


<210>  5265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5265
aauguaacuu aaauaacaaa                                                   20


<210>  5266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5266
ucauuuuaca acagcuccuu                                                   20


<210>  5267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5267
accucacacu uucucuucac                                                   20


<210>  5268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5268
gcacuaauua agccuugaaa                                                   20


<210>  5269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5269
guuauugaac uaccucugca                                                   20


<210>  5270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5270
gcuuugacua aaaacagaau                                                   20


<210>  5271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5271
ucagcuuuga cuaaaaacag                                                   20


<210>  5272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5272
uuucagugcu uauucucagu                                                   20


<210>  5273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5273
aucuuuucag ugcuuauucu                                                   20


<210>  5274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5274
cugcuguccu ggagugauac                                                   20


<210>  5275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5275
cuccaggaca gcagggaucu                                                   20


<210>  5276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5276
ugcuuguacu aaccacuuuu                                                   20


<210>  5277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5277
uuuucuguca ugguuuaaaa                                                   20


<210>  5278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5278
cccaugaguc cuuacugagc                                                   20


<210>  5279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5279
agcacugggc ucuguccagg                                                   20


<210>  5280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5280
cacacccacc augggcucug                                                   20


<210>  5281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5281
caggcccuaa ucccacaccc                                                   20


<210>  5282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5282
uuguggggag caaggaaaaa                                                   20


<210>  5283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5283
cuuuacuguu aauugucaua                                                   20


<210>  5284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5284
auuauguuau uauuaaaaag                                                   20


<210>  5285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5285
uaaccacucu ucuggugcac                                                   20


<210>  5286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5286
ucagccucuc agaugaucau                                                   20


<210>  5287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5287
gagaggcuga agauagugga                                                   20


<210>  5288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5288
ucugagaggc ugaagauagu                                                   20


<210>  5289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5289
uggcaucagu uaaaauuggg                                                   20


<210>  5290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5290
ucaaaugagu uucacccaau                                                   20


<210>  5291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5291
ccuuuuaaag cauuguacuc                                                   20


<210>  5292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5292
ugguuuuucc augucuguuc                                                   20


<210>  5293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5293
uugaguaacg uuggauauug                                                   20


<210>  5294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5294
aacguuacuc aaggauauug                                                   20


<210>  5295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5295
uucagaagac cugugaguug                                                   20


<210>  5296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5296
gucacugugu gacucccagg                                                   20


<210>  5297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5297
gugguuggag aagccuggga                                                   20


<210>  5298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5298
aggcauuuac cugaugaaug                                                   20


<210>  5299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5299
gguaaaugcc uugauuacuu                                                   20


<210>  5300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5300
uuucaaauac aucuagcaca                                                   20


<210>  5301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5301
agcacauucc cauuaagcca                                                   20


<210>  5302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5302
ccaaaauaaa ugcaccuugc                                                   20


<210>  5303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5303
aaaaugaaau gaauuugaaa                                                   20


<210>  5304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5304
uaggugaauu agacauucaa                                                   20


<210>  5305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5305
ccugccugug aaauaaugga                                                   20


<210>  5306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5306
ugaguuuggc auuggaaaug                                                   20


<210>  5307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5307
cuaacuugac ucugggcuca                                                   20


<210>  5308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5308
ccugugcaga aaggaguggg                                                   20


<210>  5309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5309
uacuuauuuu acucugcuau                                                   20


<210>  5310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5310
aaaaaacaaa aaacaaaaaa                                                   20


<210>  5311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5311
uggccauuua accuaaucua                                                   20


<210>  5312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5312
uaucuuguac aaauugagug                                                   20


<210>  5313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5313
uguacaaauu gagugccucu                                                   20


<210>  5314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5314
gcagacagag gcacucaauu                                                   20


<210>  5315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5315
aaagcuuuuc agaauaugca                                                   20


<210>  5316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5316
uaaguguaga cagacaucuc                                                   20


<210>  5317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5317
caugugucuu gcuaagcaca                                                   20


<210>  5318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5318
aaaaggugcu gcaccuuuug                                                   20


<210>  5319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5319
cgaauuuaga guuuaguuua                                                   20


<210>  5320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5320
auauuucaaa guguaccccc                                                   20


<210>  5321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5321
uucugggggg uacacuuuga                                                   20


<210>  5322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5322
ucuuccaccc acuggcugau                                                   20


<210>  5323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5323
gccagugggu ggaagaggau                                                   20


<210>  5324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5324
cuuuaguuuc agcuuugauc                                                   20


<210>  5325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5325
aagcugaaac uaaagugauu                                                   20


<210>  5326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5326
cuguuaaaau gcaaauaccu                                                   20


<210>  5327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5327
gcccuuuaca guccaccgag                                                   20


<210>  5328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5328
aagaaaagca uuagcugaac                                                   20


<210>  5329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5329
uucuacugaa agauaauuca                                                   20


<210>  5330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5330
uucaguagaa ugauagcuug                                                   20


<210>  5331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5331
ucaggguuca gccuuucugu                                                   20


<210>  5332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5332
guuccuaaau ugcauaguau                                                   20


<210>  5333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5333
cauuuacauu uuauauacua                                                   20


<210>  5334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5334
caccacucuu aaauuauuau                                                   20


<210>  5335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5335
cacucuucca aaugaauuuu                                                   20


<210>  5336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5336
accucacaga gauuagugau                                                   20


<210>  5337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5337
cugugaggua gaucccacuc                                                   20


<210>  5338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5338
cuaaucucug ugagguagau                                                   20


<210>  5339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5339
uguauuuuua augaauauca                                                   20


<210>  5340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5340
auaggagaaa ccccaugaca                                                   20


<210>  5341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5341
aauuugauua aacugugcuu                                                   20


<210>  5342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5342
aauuagaugg ugggcuaugu                                                   20


<210>  5343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5343
uuaaaacagc cugcaauaau                                                   20


<210>  5344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5344
uuuuaaggcu auugaacuaa                                                   20


<210>  5345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5345
aagugagcua auuuuucuua                                                   20


<210>  5346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5346
aaucaaagug agcuaauuuu                                                   20


<210>  5347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5347
aauagaauca aaucaaagug                                                   20


<210>  5348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5348
uacaauccca gccagcuaac                                                   20


<210>  5349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5349
cagccagcua acugcuagaa                                                   20


<210>  5350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5350
uuaauaacca uucauuuaug                                                   20


<210>  5351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5351
agccugacau gcucauccga                                                   20


<210>  5352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5352
gaggagcugg gcuguagcaa                                                   20


<210>  5353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5353
ucccuuucua cgacuaggaa                                                   20


<210>  5354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5354
ccucuccucu cccuccccuu                                                   20


<210>  5355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5355
aaggcucugu cuugcuucuc                                                   20


<210>  5356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5356
gucuacauuu gggagaagcu                                                   20


<210>  5357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5357
cagcaggaga gguuggcuca                                                   20


<210>  5358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5358
ggguguccca gggagcuucc                                                   20


<210>  5359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5359
gccucagucu ucuuugcaga                                                   20


<210>  5360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5360
cuuucccugg ugaaaagcca                                                   20


<210>  5361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5361
gagaguuggu gugauacugc                                                   20


<210>  5362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5362
caccaacucu cagaucacuu                                                   20


<210>  5363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5363
gaagaaagag acaaacuggg                                                   20


<210>  5364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5364
auuuucuuua agucuuuccc                                                   20


<210>  5365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5365
aaugaauaau ucacuaaaug                                                   20


<210>  5366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5366
acagcgacag cucugaguaa                                                   20


<210>  5367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5367
acuaaccauu acuacuccuu                                                   20


<210>  5368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5368
agaaauauuu ccucucccuu                                                   20


<210>  5369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5369
aaugaaaaag cccuguauuu                                                   20


<210>  5370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5370
cacgagacua auucacacca                                                   20


<210>  5371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5371
gaugguuuua ccagggguuu                                                   20


<210>  5372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5372
gaucucacga gacuaauuca                                                   20


<210>  5373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5373
uccucauucu cucuuugccu                                                   20


<210>  5374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5374
auguaagaug gaacuuucuc                                                   20


<210>  5375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5375
uacauggaug gcagcaggca                                                   20


<210>  5376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5376
cagacaaccc aacacuuuuu                                                   20


<210>  5377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5377
ugugcgugca ugcacguauu                                                   20


<210>  5378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5378
acucccccaa ccuaccccuu                                                   20


<210>  5379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5379
agggucuucu agguucaccu                                                   20


<210>  5380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5380
ccaaauaugu aauucuugau                                                   20


<210>  5381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5381
agaauuacau auuuggagau                                                   20


<210>  5382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5382
uccaauugga auuaaaaauu                                                   20


<210>  5383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5383
aaauguaggu caaguaauuu                                                   20


<210>  5384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5384
ucugacucug uuuuugagca                                                   20


<210>  5385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5385
gcagcagcug uuucaagaac                                                   20


<210>  5386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5386
caaauccagu uguuuuaaca                                                   20


<210>  5387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5387
aguuguuuua acagaaaaua                                                   20


<210>  5388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5388
cagucugcca cuuucccaua                                                   20


<210>  5389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5389
cauaaauuuu ccacuuuaaa                                                   20


<210>  5390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5390
cuuuacccca guuuuuaggg                                                   20


<210>  5391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5391
aucucuuuac cccaguuuuu                                                   20


<210>  5392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5392
gcgguuuugg acccaaaaug                                                   20


<210>  5393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5393
caacagguuu ccuguaugug                                                   20


<210>  5394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5394
cuguugacac auacucaauu                                                   20


<210>  5395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5395
uuuccaauag guccuggcug                                                   20


<210>  5396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5396
cagaaaguug ggacaaagga                                                   20


<210>  5397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5397
aaugcaguua aaaggcacuu                                                   20


<210>  5398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5398
ccaggcccua agccauaauc                                                   20


<210>  5399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5399
gaaaaugcac cguggcucua                                                   20


<210>  5400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5400
ucugaaaaug caccguggcu                                                   20


<210>  5401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5401
acaagucagu cccugccggu                                                   20


<210>  5402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5402
ucuggccuua ccggcaggga                                                   20


<210>  5403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5403
uauaagugug ucauuuuuca                                                   20


<210>  5404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5404
aguucugcuu cuccaagauu                                                   20


<210>  5405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5405
cauccaguuc ugcuucucca                                                   20


<210>  5406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5406
uaauugagua agcagacaca                                                   20


<210>  5407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5407
auuauguagu acacuguuag                                                   20


<210>  5408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5408
agcucacaga agacugcugc                                                   20


<210>  5409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5409
aucaagcuca cagaagacug                                                   20


<210>  5410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5410
gcuacaauga cauggcaaag                                                   20


<210>  5411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5411
auacccccuu uuguaccuaa                                                   20


<210>  5412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5412
uauuuuauug ccuucaagcu                                                   20


<210>  5413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5413
ugccagucga cucagaagaa                                                   20


<210>  5414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5414
cuuggggacu agagcuguga                                                   20


<210>  5415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5415
cagcucuagu ccccaaggga                                                   20


<210>  5416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5416
uaauauguuu aauuuuauca                                                   20


<210>  5417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5417
cacuucauca ucaauaaagc                                                   20


<210>  5418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5418
ucaauaaagc aauuacacau                                                   20


<210>  5419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5419
auaaagcaau uacacauauc                                                   20


<210>  5420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5420
gaucuaauuu aauucucuca                                                   20


<210>  5421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5421
gauaugugua auugcuuuau                                                   20


<210>  5422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5422
aauuuaauuc ucucacuaac                                                   20


<210>  5423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5423
uucccucauu acaaaaaacc                                                   20


<210>  5424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5424
augcuacugu uuugguguug                                                   20


<210>  5425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5425
cuaguuacca uauaaacccu                                                   20


<210>  5426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5426
agauaaaaga gacucacccu                                                   20


<210>  5427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5427
ugaucacuag uuaccauaua                                                   20


<210>  5428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5428
uguugcucca uuauucuuaa                                                   20


<210>  5429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5429
caugguccaa cauggcugcu                                                   20


<210>  5430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5430
cauaaauucu aaccaauagg                                                   20


<210>  5431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5431
aaaacucuuc ugguugcaag                                                   20


<210>  5432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5432
cuugcaacca gaagaguuuu                                                   20


<210>  5433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5433
aaccacaugg cucagucuca                                                   20


<210>  5434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5434
uucccaggca gguucucuuu                                                   20


<210>  5435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5435
ccucugcugg accagaguug                                                   20


<210>  5436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5436
uugagccaau cauggugucu                                                   20


<210>  5437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5437
uggugucucu gacuggccug                                                   20


<210>  5438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5438
caagggggga cgagaguggu                                                   20


<210>  5439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5439
uguugacguu ugaucccuga                                                   20


<210>  5440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5440
cuuaguauag uacuuacuuc                                                   20


<210>  5441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5441
ucacccccug uccccuaggc                                                   20


<210>  5442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5442
caacccaugc agaagcaucu                                                   20


<210>  5443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5443
gacugaagag uuuagugaac                                                   20


<210>  5444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5444
gaaaguccau aagaacuaaa                                                   20


<210>  5445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5445
uccaaaaguc uccauuggug                                                   20


<210>  5446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5446
cccucaaaaa gucugugcaa                                                   20


<210>  5447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5447
ccucuccuuc agaucauggu                                                   20


<210>  5448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5448
gaaggagagg ugauuugucu                                                   20


<210>  5449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5449
uggugagauu caauaauuuu                                                   20


<210>  5450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5450
caccaugauc ugaaggagag                                                   20


<210>  5451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5451
cuaaauaaau aaauaaaauu                                                   20


<210>  5452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5452
cagcacuuug ggaggcugag                                                   20


<210>  5453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5453
guaaucccag cacuuuggga                                                   20


<210>  5454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5454
uuauuggcca ggcgcguggc                                                   20


<210>  5455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5455
uucaaaguaa aaauagaggg                                                   20


<210>  5456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5456
uugcuauuuu aucuuucaaa                                                   20


<210>  5457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5457
cagcugugag guguagggaa                                                   20


<210>  5458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5458
gacccuccac aucuauagag                                                   20


<210>  5459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5459
auagagguac aucugcaauu                                                   20


<210>  5460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5460
gcaauugaga ugcauaucac                                                   20


<210>  5461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5461
uucuuauaag ugauaugcau                                                   20


<210>  5462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5462
augugaccug ugaugacaaa                                                   20


<210>  5463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5463
caggucacau ggauuaaagu                                                   20


<210>  5464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5464
cacggcuagu aacuauuaac                                                   20


<210>  5465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5465
cuuccuuuuu auaggugagg                                                   20


<210>  5466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5466
gcguaagcac acacugugug                                                   20


<210>  5467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5467
guguuugauu aaccuucgac                                                   20


<210>  5468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5468
aacacagaug ggggaaaugu                                                   20


<210>  5469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5469
guugugacua ggccaagagg                                                   20


<210>  5470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5470
uaacaaaaaa aauuaaacag                                                   20


<210>  5471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5471
uguuaacuuu agucacaauu                                                   20


<210>  5472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5472
aucuuguuaa cuuuagucac                                                   20


<210>  5473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5473
uggcugcaca uuaaaaucac                                                   20


<210>  5474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5474
ccugcagagc uuuaaaaacu                                                   20


<210>  5475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5475
gaaucaccug cagagcuuua                                                   20


<210>  5476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5476
gagauuucaa aacucuauca                                                   20


<210>  5477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5477
ccgauucuga gucccggcua                                                   20


<210>  5478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5478
gaacuugaca aaugacagca                                                   20


<210>  5479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5479
gaaagcagcu ucccccgagg                                                   20


<210>  5480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5480
uguagcauau auuuuggagc                                                   20


<210>  5481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5481
acugucaaaa gacaaaaauu                                                   20


<210>  5482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5482
aaacucaaau ccacugucaa                                                   20


<210>  5483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5483
uuugaagguu uuuauccaaa                                                   20


<210>  5484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5484
agcucgcuga auaugcuggg                                                   20


<210>  5485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5485
ugcaaaaugg cccagcauau                                                   20


<210>  5486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5486
ccuuggccau auguuguguu                                                   20


<210>  5487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5487
auccccuugg ccauauguug                                                   20


<210>  5488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5488
gucucaugcg ccucauaauu                                                   20


<210>  5489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5489
acauugucuu uuaaugacag                                                   20


<210>  5490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5490
ggauguguga gggcuggcgg                                                   20


<210>  5491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5491
agaucaacau ugucuuuuaa                                                   20


<210>  5492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5492
gccucauuau guacggguca                                                   20


<210>  5493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5493
cuguucaggg acaccagacu                                                   20


<210>  5494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5494
caccugguug cagaguuucc                                                   20


<210>  5495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5495
ucucaccugg uugcagaguu                                                   20


<210>  5496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5496
caacgcaaua uugaaucauc                                                   20


<210>  5497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5497
gauaaauccu aacuggugag                                                   20


<210>  5498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5498
gauagaaugu gagggaauuu                                                   20


<210>  5499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5499
uaacugguga gagcacaaca                                                   20


<210>  5500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5500
uaaaucaacc ggacuuuacu                                                   20


<210>  5501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5501
accggacuuu acuuccagcu                                                   20


<210>  5502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5502
ugcaguuauu uucuuuccca                                                   20


<210>  5503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5503
gggaaagaaa auaacugcaa                                                   20


<210>  5504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5504
caucugggaa agaaaauaac                                                   20


<210>  5505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5505
gcuguggaca uuaaccauug                                                   20


<210>  5506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5506
uacagacaga agacuccaga                                                   20


<210>  5507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5507
gcauuugaau ggcucugaga                                                   20


<210>  5508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5508
uuuuucauua uuguaguuuu                                                   20


<210>  5509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5509
caucuccucu gccucuaaca                                                   20


<210>  5510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5510
ccucugccuc uaacauuuca                                                   20


<210>  5511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5511
ggcccuggau uuuacauagc                                                   20


<210>  5512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5512
agggccugau uggaaggcuu                                                   20


<210>  5513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5513
cucauaaggu gaaugcuugu                                                   20


<210>  5514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5514
ugguauuuug cauuucuaaa                                                   20


<210>  5515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5515
cagaagaguc agcauuuggg                                                   20


<210>  5516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5516
gccuucacac cucccuuuaa                                                   20


<210>  5517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5517
gucauggcag cccauccagc                                                   20


<210>  5518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5518
agcucuguuc ucagggagcu                                                   20


<210>  5519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5519
gcugcuaaag uuagcucccu                                                   20


<210>  5520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5520
gcuggcggag uuugacacag                                                   20


<210>  5521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5521
ugagaacuaa ucaucccccu                                                   20


<210>  5522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5522
ucccccuacu uuccuaacgu                                                   20


<210>  5523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5523
cccuacuuuc cuaacgugua                                                   20


<210>  5524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5524
aaguuaacaa gcaguccuau                                                   20


<210>  5525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5525
ggagcccauc uucugacuuc                                                   20


<210>  5526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5526
ucugacuuca aaauaaauaa                                                   20


<210>  5527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5527
uuuuuauuua uuuugaaguc                                                   20


<210>  5528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5528
gaguuauaga aaaucuuuuu                                                   20


<210>  5529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5529
ucaccuuucu ccaaauaaag                                                   20


<210>  5530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5530
ccucaagugg uuaaaagguu                                                   20


<210>  5531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5531
cugagucgag cucacaugug                                                   20


<210>  5532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5532
uuucgcuguu uguuagaagu                                                   20


<210>  5533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5533
uaguaauuua ucuuauuuau                                                   20


<210>  5534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5534
uauuuauuuu ccuaaaaagu                                                   20


<210>  5535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5535
cauuguuaua ggggccaaga                                                   20


<210>  5536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5536
uaauagcccc auuuaaaauu                                                   20


<210>  5537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5537
cugcuuagcu gcaacaccgu                                                   20


<210>  5538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5538
ggagaccaau cacugcuuag                                                   20


<210>  5539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5539
ccaaaaccuc caacuuucaa                                                   20


<210>  5540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5540
ucacaaaugc auugugcagc                                                   20


<210>  5541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5541
uguggcacca aaauaagggu                                                   20


<210>  5542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5542
aaacccuuau uuuggugcca                                                   20


<210>  5543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5543
aaucuaaacc cuuauuuugg                                                   20


<210>  5544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5544
gggacaggua gcaaauuugc                                                   20


<210>  5545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5545
uucagcuuug aucugcuucc                                                   20


<210>  5546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5546
aagcugaaug aucugggaca                                                   20


<210>  5547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5547
gcuuccaaca agucuuagga                                                   20


<210>  5548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5548
acgucuuuaa ggaacuauuu                                                   20


<210>  5549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5549
ggaauucaaa gaaccuuuaa                                                   20


<210>  5550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5550
caggcuuuca auguggggcu                                                   20


<210>  5551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5551
ucagagccga ggccccuacc                                                   20


<210>  5552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5552
gagccgaggc cccuacccca                                                   20


<210>  5553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5553
cucaccuucc uucauuucag                                                   20


<210>  5554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5554
uguuucaaug acucugcugc                                                   20


<210>  5555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5555
ugcuccaaga uaguaaacuu                                                   20


<210>  5556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5556
uggagcauga ugcauuguca                                                   20


<210>  5557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5557
uacagagguc augagaaaaa                                                   20


<210>  5558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5558
aguggagguu agcaaacugu                                                   20


<210>  5559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5559
uccaagcacu guaaaagcac                                                   20


<210>  5560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5560
aagcacugua aaagcacaaa                                                   20


<210>  5561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5561
uuugugcuuu uacagugcuu                                                   20


<210>  5562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5562
ucgggcucag uuuauuauaa                                                   20


<210>  5563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5563
guaaaacauc uuuuugacag                                                   20


<210>  5564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5564
uuuugacagu gucuuuuuaa                                                   20


<210>  5565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5565
ugugcuaccu cuccuuuaag                                                   20


<210>  5566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5566
uccccccuca cuuucccaca                                                   20


<210>  5567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5567
ccccucacuu ucccacacgu                                                   20


<210>  5568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5568
ucuuguguac gugugggaaa                                                   20


<210>  5569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5569
ccaucgccuc ucugcaugcc                                                   20


<210>  5570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5570
ccucucugca ugccagagac                                                   20


<210>  5571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5571
uucucaguag ucucguuucu                                                   20


<210>  5572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5572
aggaacaauu cugccgugaa                                                   20


<210>  5573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5573
ugaguuaaug uuacuugcag                                                   20


<210>  5574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5574
uuuuauuugu auuuccuggg                                                   20


<210>  5575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5575
ucuuuuuauu uguauuuccu                                                   20


<210>  5576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5576
gugacucuug agagcauuug                                                   20


<210>  5577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5577
aagguuugag cuauaguuag                                                   20


<210>  5578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5578
uagaaaaauc caagguuuga                                                   20


<210>  5579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5579
uaccucucuc ccacaguaau                                                   20


<210>  5580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5580
uacgguuuaa ccacccagga                                                   20


<210>  5581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5581
caagaagcuc aggguucaca                                                   20


<210>  5582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5582
uauccccaaa aggaaagaca                                                   20


<210>  5583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5583
ccaaaaggaa agacaaguua                                                   20


<210>  5584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5584
cacauucuuu aacuugucuu                                                   20


<210>  5585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5585
cugcuuuugu guauuccagu                                                   20


<210>  5586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5586
acaauacuuu ggaggguuag                                                   20


<210>  5587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5587
gcugaauaaa uauugagggg                                                   20


<210>  5588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5588
uaauaacccc ucaauauuua                                                   20


<210>  5589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5589
ucuauuuugu auuggaauca                                                   20


<210>  5590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5590
acuuauugug uacaauauau                                                   20


<210>  5591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5591
aaaagucaaa aauaaaagcu                                                   20


<210>  5592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5592
cuggcugggg agcuuuuauu                                                   20


<210>  5593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5593
uuaugcuuca acucagguac                                                   20


<210>  5594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5594
uccuggcccu cgugcaugcu                                                   20


<210>  5595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5595
agugacuugc agcucugugg                                                   20


<210>  5596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5596
uagcacuuug ggaagccaag                                                   20


<210>  5597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5597
gcccaccuug gcuucccaaa                                                   20


<210>  5598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5598
cuugagcuca gaaguuugag                                                   20


<210>  5599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5599
caagggaaag uguggcaaaa                                                   20


<210>  5600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5600
ucuguguugc caccucccgu                                                   20


<210>  5601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5601
ggugaccgca cauguuucua                                                   20


<210>  5602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5602
ccccaaguca uuaggcuggu                                                   20


<210>  5603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5603
aagagaaagg agaguggagc                                                   20


<210>  5604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5604
auguacagcu ccacucuccu                                                   20


<210>  5605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5605
ucuucggaga ccccaaaggu                                                   20


<210>  5606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5606
gugccagcca caaaacuuau                                                   20


<210>  5607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5607
gcguauagaa cauuccacua                                                   20


<210>  5608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5608
acgaccauga gaggguuguc                                                   20


<210>  5609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5609
gggacugcua ucuacgacca                                                   20


<210>  5610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5610
accggaggcc aauuaaaaga                                                   20


<210>  5611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5611
aaauauuucc acuucgcuca                                                   20


<210>  5612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5612
auuuugagcg aaguggaaau                                                   20


<210>  5613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5613
caggacuguu uggaauccau                                                   20


<210>  5614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5614
cugagaaucc caggacuguu                                                   20


<210>  5615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5615
uuuagauuuu cugcuuaaaa                                                   20


<210>  5616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5616
aaaagauggu cuagcuagga                                                   20


<210>  5617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5617
uggggugugg agaggaggag                                                   20


<210>  5618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5618
aaauuaauaa guacccuauc                                                   20


<210>  5619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5619
uauuaaagau aaugaauuuu                                                   20


<210>  5620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5620
uuaauaggau uucuuuacua                                                   20


<210>  5621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5621
acaguggucg cagcuuugug                                                   20


<210>  5622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5622
ucuucuccuc auguugaguu                                                   20


<210>  5623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5623
gaagggagug ucccugaagg                                                   20


<210>  5624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5624
uuguguuuuu cuuucuccuu                                                   20


<210>  5625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence ATCN PAM

<400>  5625
aggccaauuu uuuauuucuu                                                   20


<210>  5626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5626
aacgcagcau cugugccagg                                                   20


<210>  5627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5627
cucugcucuc uguggagucc                                                   20


<210>  5628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5628
gcucucugug gaguccucca                                                   20


<210>  5629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5629
cuguggaguc cuccacccac                                                   20


<210>  5630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5630
guggaguccu ccacccacgc                                                   20


<210>  5631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5631
acagagagca gagggagcag                                                   20


<210>  5632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5632
acccacgccc acgcccaggc                                                   20


<210>  5633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5633
gguugggggu gggguagccu                                                   20


<210>  5634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5634
guucacauca uucgggcucu                                                   20


<210>  5635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5635
gcagguggca gggagggggg                                                   20


<210>  5636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5636
cugccaccug cagagcccug                                                   20


<210>  5637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5637
ccccucccug ccaccugcag                                                   20


<210>  5638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5638
auuauuuccu ugcgugugca                                                   20


<210>  5639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5639
caagcauaaa caauccaguc                                                   20


<210>  5640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5640
uuuaacacug augcugggua                                                   20


<210>  5641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5641
uuucuccuuu aacacugaug                                                   20


<210>  5642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5642
cccucccagg uucaagcaau                                                   20


<210>  5643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5643
cucccagguu caagcaauuc                                                   20


<210>  5644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5644
cagguucaag caauucuccu                                                   20


<210>  5645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5645
ugccucagcc ucacaaguau                                                   20


<210>  5646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5646
gccucacaag uaucugggac                                                   20


<210>  5647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5647
caaguaucug ggacuacaca                                                   20


<210>  5648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5648
acuaaaaaua caaaaauuag                                                   20


<210>  5649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5649
aacuccuggc cucaagugau                                                   20


<210>  5650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5650
uggccucaag ugauccacuu                                                   20


<210>  5651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5651
agugauccac uugcuuuggc                                                   20


<210>  5652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5652
caaaguucug gaauuacagu                                                   20


<210>  5653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5653
cgacuguaau uccagaacuu                                                   20


<210>  5654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5654
gcuggagaug ucagaguuau                                                   20


<210>  5655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5655
agccgagugu gguggcucac                                                   20


<210>  5656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5656
gacaucucca gccgagugug                                                   20


<210>  5657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5657
gcaacuuccu aguuacauga                                                   20


<210>  5658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5658
auuucuuuga ccuucagcuu                                                   20


<210>  5659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5659
auuucuucag augacaagcu                                                   20


<210>  5660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5660
uaaguugcua uagguaggga                                                   20


<210>  5661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5661
ugugucccca cuucucccca                                                   20


<210>  5662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5662
ccacaugauu ugaacauguu                                                   20


<210>  5663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5663
ccggaccucc auuuucucau                                                   20


<210>  5664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5664
ggaccuccau uuucucauau                                                   20


<210>  5665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5665
auuuucucau augcaagaug                                                   20


<210>  5666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5666
uaugcaagau gagaagguug                                                   20


<210>  5667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5667
ucuugcauau gagaaaaugg                                                   20


<210>  5668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5668
accuucucau cuugcauaug                                                   20


<210>  5669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5669
acgguguuga agccacugau                                                   20


<210>  5670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5670
ggcauggaac aagaugccca                                                   20


<210>  5671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5671
guuuacuaga uauuuuccug                                                   20


<210>  5672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5672
acaguccaag aucucuguuu                                                   20


<210>  5673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5673
ucccuugaga cuggcaagug                                                   20


<210>  5674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5674
agggaagaga cuauccuuag                                                   20


<210>  5675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5675
cuugccaguc ucaagggaag                                                   20


<210>  5676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5676
uugcuuggau uagaacaaaa                                                   20


<210>  5677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5677
gggauaggag aggaaugagu                                                   20


<210>  5678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5678
uaucccugag guccucuuug                                                   20


<210>  5679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5679
ccuaucccug agguccucuu                                                   20


<210>  5680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5680
uuccucuccu aucccugagg                                                   20


<210>  5681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5681
cauuacuacc uccuaaguca                                                   20


<210>  5682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5682
uaagucaggc uuucagaauc                                                   20


<210>  5683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5683
ucuuaggaca auugugaggg                                                   20


<210>  5684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5684
caauuguccu aagaagagau                                                   20


<210>  5685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5685
uaacuuguca ugcugcuuca                                                   20


<210>  5686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5686
agccuauccu agauagcaca                                                   20


<210>  5687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5687
ggcugugcua ucuaggauag                                                   20


<210>  5688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5688
cucaugcuca aaauccuuuc                                                   20


<210>  5689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5689
caugcucaaa auccuuuccc                                                   20


<210>  5690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5690
ugcucaaaau ccuuucccag                                                   20


<210>  5691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5691
aaauccuuuc ccagugcgca                                                   20


<210>  5692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5692
uucuucccuc cacccagagu                                                   20


<210>  5693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5693
acccagagua ccuucgacau                                                   20


<210>  5694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5694
ggguggaggg aagaacgagu                                                   20


<210>  5695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5695
uccucaugag uucuuggaug                                                   20


<210>  5696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5696
ugaguucuug gaugaaauag                                                   20


<210>  5697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5697
ugaggaugag cuucuuggaa                                                   20


<210>  5698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5698
cuauuucauc caagaacuca                                                   20


<210>  5699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5699
cuggagaauu ucaagaagaa                                                   20


<210>  5700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5700
agugaguggg aacucccuau                                                   20


<210>  5701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5701
agcacaugcu caggaaucuu                                                   20


<210>  5702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5702
ggaaucuuua uugguucucc                                                   20


<210>  5703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5703
auguucuauu gaauuaaaaa                                                   20


<210>  5704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5704
aacugacagu caauacaauc                                                   20


<210>  5705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5705
cccagauucc cacccuacua                                                   20


<210>  5706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5706
ggauuagcag gggacuaggc                                                   20


<210>  5707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5707
aucucuaucu uuauccauau                                                   20


<210>  5708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5708
aucuuuaucc auaucccuac                                                   20


<210>  5709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5709
uguccuccga uugucaaaac                                                   20


<210>  5710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5710
gauugucaaa acuugacccc                                                   20


<210>  5711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5711
uuugagauuu auuucaaauc                                                   20


<210>  5712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5712
aaggaggggu caaguuuuga                                                   20


<210>  5713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5713
gcugcuuucc cuaauucuau                                                   20


<210>  5714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5714
uuccaagccc uuuaacuccu                                                   20


<210>  5715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5715
uguguuucuu guuuuucccu                                                   20


<210>  5716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5716
uuggcacuuc agucaagggu                                                   20


<210>  5717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5717
aaguguaccc uugacugaag                                                   20


<210>  5718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5718
auggccuuau guucuccaag                                                   20


<210>  5719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5719
auaauuccua aaugcuaugg                                                   20


<210>  5720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5720
cucaauaauu ccuaaaugcu                                                   20


<210>  5721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5721
cgaaggucca ugucuuggcu                                                   20


<210>  5722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5722
aagguccaug ucuuggcugu                                                   20


<210>  5723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5723
uguguuuugu acaacagcca                                                   20


<210>  5724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5724
uccaguucug gccuuccaga                                                   20


<210>  5725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5725
augacaucuu cugaacucug                                                   20


<210>  5726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5726
gcuuuuccca aaucccuuug                                                   20


<210>  5727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5727
cccccacccc aucacguaac                                                   20


<210>  5728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5728
ugcaagcuac uguuugugua                                                   20


<210>  5729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5729
caaaucaauu acaaaaacaa                                                   20


<210>  5730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5730
ccagcugcag ugaaauugcu                                                   20


<210>  5731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5731
caacacagca auuucacugc                                                   20


<210>  5732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5732
uuuaugcccu acuaugccua                                                   20


<210>  5733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5733
gggcuaggca cauaaaaaug                                                   20


<210>  5734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5734
aguccugccu ggagcugaaa                                                   20


<210>  5735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5735
aggcaggacu ggagaagguu                                                   20


<210>  5736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5736
aacgugugag gagaggcccu                                                   20


<210>  5737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5737
cacguuggag cuguaaguag                                                   20


<210>  5738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5738
ucacacguug gagcuguaag                                                   20


<210>  5739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5739
ccucacacgu uggagcugua                                                   20


<210>  5740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5740
cacuuccuca gacacauuuu                                                   20


<210>  5741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5741
cuuccucaga cacauuuuua                                                   20


<210>  5742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5742
gacacauuuu uagagaauca                                                   20


<210>  5743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5743
aaaaaugugu cugaggaagu                                                   20


<210>  5744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5744
gaugauucuc uaaaaaugug                                                   20


<210>  5745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5745
caucaccuca gccuuucaac                                                   20


<210>  5746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5746
gccuuucaac uuggugggag                                                   20


<210>  5747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5747
caccaaguug aaaggcugag                                                   20


<210>  5748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5748
cccaccaagu ugaaaggcug                                                   20


<210>  5749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5749
ugauuccuag cccaugauau                                                   20


<210>  5750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5750
acaagacacu cauccucucc                                                   20


<210>  5751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5751
uccucuccaa gccucguucu                                                   20


<210>  5752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5752
ccaagccucg uucuucucau                                                   20


<210>  5753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5753
aagccucguu cuucucaucu                                                   20


<210>  5754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5754
uucuucucau cuuuagaaug                                                   20


<210>  5755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5755
ucuuuagaau gaggagaugg                                                   20


<210>  5756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5756
uucuaaagau gagaagaacg                                                   20


<210>  5757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5757
ucauucuaaa gaugagaaga                                                   20


<210>  5758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5758
gccagucccu uccagccuca                                                   20


<210>  5759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5759
gcugugcaga cauugugugc                                                   20


<210>  5760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5760
uccccauagc acacaauguc                                                   20


<210>  5761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5761
cccuggaccu gugcccauua                                                   20


<210>  5762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5762
ugcaauguug ugugacugug                                                   20


<210>  5763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5763
ggggcccggg ccuguggccc                                                   20


<210>  5764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5764
ugacuuacca ggaaaggcua                                                   20


<210>  5765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5765
cuuaggcuuc ucuugacuua                                                   20


<210>  5766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5766
uugaugaucc agauauggau                                                   20


<210>  5767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5767
cuagaugugu ccuuaggugu                                                   20


<210>  5768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5768
cacucacauc cuugaagcag                                                   20


<210>  5769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5769
cucacauccu ugaagcaggu                                                   20


<210>  5770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5770
cauccuugaa gcagguggca                                                   20


<210>  5771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5771
ugggaaccac acaauucccc                                                   20


<210>  5772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5772
gugggggaau uccucuccau                                                   20


<210>  5773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5773
ccauuccucu cugcccgacu                                                   20


<210>  5774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5774
auuccucucu gcccgacugc                                                   20


<210>  5775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5775
cugcccgacu gcccuccuca                                                   20


<210>  5776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5776
gcccgacugc ccuccucacc                                                   20


<210>  5777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5777
ucaccugcuu ccaccugcug                                                   20


<210>  5778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5778
ccugcuucca ccugcuguua                                                   20


<210>  5779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5779
uguuucuaac agcaggugga                                                   20


<210>  5780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5780
ccuguuucua acagcaggug                                                   20


<210>  5781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5781
aagaccaucu gguccacccu                                                   20


<210>  5782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5782
uugucuacag auucagaaac                                                   20


<210>  5783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5783
guuucugaau cuguagacaa                                                   20


<210>  5784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5784
ggacucaguu ucugaaucug                                                   20


<210>  5785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5785
cuggacucag uuucugaauc                                                   20


<210>  5786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5786
cucuggacuc aguuucugaa                                                   20


<210>  5787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5787
cuuggggcau gcagcugccu                                                   20


<210>  5788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5788
ggcagcugca ugccccaagu                                                   20


<210>  5789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5789
cucaggcagc ugcaugcccc                                                   20


<210>  5790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5790
acacgucuca gagaagccag                                                   20


<210>  5791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5791
gagaagccag ccagggcucc                                                   20


<210>  5792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5792
gagacguguu gaguggcuug                                                   20


<210>  5793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5793
cuucccccuu cuggaggccg                                                   20


<210>  5794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5794
agaaggggga agggagcccu                                                   20


<210>  5795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5795
cgacucaggg aacagggugg                                                   20


<210>  5796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5796
acucagggaa caggguggga                                                   20


<210>  5797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5797
gggaacaggg ugggaaagcu                                                   20


<210>  5798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5798
gggggagcag ccaggaacac                                                   20


<210>  5799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5799
cccugagaag cuuucccacc                                                   20


<210>  5800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5800
guucucugca ccaguggcga                                                   20


<210>  5801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5801
gcaccagugg cgaaggcugg                                                   20


<210>  5802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5802
gggggcuuaa uguggguaua                                                   20


<210>  5803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5803
ucccugccug uccugcuuac                                                   20


<210>  5804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5804
caguuccagc cugaacacug                                                   20


<210>  5805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5805
uaacaauagc uuuuuuuugu                                                   20


<210>  5806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5806
aucccuaaua gggaacgggg                                                   20


<210>  5807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5807
gaucucuauc ccuaauaggg                                                   20


<210>  5808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5808
auagaaguaa auuccacaag                                                   20


<210>  5809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5809
cugccugucu aaauccucuc                                                   20


<210>  5810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5810
gccugucuaa auccucucuu                                                   20


<210>  5811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5811
cuucuuugaa aagcagcuca                                                   20


<210>  5812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5812
ucuuugaaaa gcagcucaga                                                   20


<210>  5813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5813
gagcugccuc uuucuugaag                                                   20


<210>  5814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5814
gagcugcuuu ucaaagaaga                                                   20


<210>  5815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5815
uucuugaagc cuuccuugcc                                                   20


<210>  5816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5816
auccucugaa cagcuugcag                                                   20


<210>  5817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5817
gaacagcuug cagcauuucc                                                   20


<210>  5818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5818
ugaaggaaau gcugcaagcu                                                   20


<210>  5819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5819
ugacgggugc ccaguuccuu                                                   20


<210>  5820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5820
ggcacaugcg uaaucuaagc                                                   20


<210>  5821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5821
ugaagacgcc cagccuuugg                                                   20


<210>  5822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5822
ucuugaagac gcccagccuu                                                   20


<210>  5823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5823
gcagcccacg gcccagcaga                                                   20


<210>  5824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5824
ccccaaagga cagcgaagcc                                                   20


<210>  5825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5825
ugaaaugcuu guuucuccug                                                   20


<210>  5826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5826
ugucagacau cccucauguc                                                   20


<210>  5827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5827
uguccccaug ccagcacccc                                                   20


<210>  5828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5828
ccguggaacu gccugggggu                                                   20


<210>  5829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5829
ccccguggaa cugccugggg                                                   20


<210>  5830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5830
ucuccccgug gaacugccug                                                   20


<210>  5831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5831
gccaccuuac acuccucucc                                                   20


<210>  5832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5832
agccugaugc caguuccaga                                                   20


<210>  5833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5833
acacugccuc acggaccagg                                                   20


<210>  5834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5834
cggaccaggu gcagcacagc                                                   20


<210>  5835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5835
cucccaucau uacagcaaca                                                   20


<210>  5836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5836
caucauuaca gcaacacaca                                                   20


<210>  5837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5837
uguuuuuccc ucuuuggcug                                                   20


<210>  5838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5838
uuggcugccc cugaagccua                                                   20


<210>  5839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5839
acuccuccuc uauggauaug                                                   20


<210>  5840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5840
uccucuaugg auauguucgg                                                   20


<210>  5841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5841
ucuauggaua uguucggaca                                                   20


<210>  5842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5842
auggauaugu ucggacaugu                                                   20


<210>  5843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5843
aguccgaaag ggcccuggga                                                   20


<210>  5844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5844
cauccuaguc uacacgcauc                                                   20


<210>  5845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5845
ucccccaggg acucccucca                                                   20


<210>  5846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5846
cuccagcucu gggaaaggcc                                                   20


<210>  5847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5847
agcucuggga aaggccaggu                                                   20


<210>  5848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5848
gggaaaggcc aggugacagc                                                   20


<210>  5849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5849
cacaccggcu cuggugugga                                                   20


<210>  5850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5850
caccggcucu gguguggaga                                                   20


<210>  5851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5851
gguguggaga ggggucagag                                                   20


<210>  5852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5852
acaccagagc cggugugaga                                                   20


<210>  5853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5853
ccacaccaga gccgguguga                                                   20


<210>  5854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5854
gaccccucuc cacaccagag                                                   20


<210>  5855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5855
guuucugguu uuacuuacuc                                                   20


<210>  5856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5856
cggaagcccc ugcccacauu                                                   20


<210>  5857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5857
gauuauuauu gaccaggacg                                                   20


<210>  5858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5858
cggauuauua uugaccagga                                                   20


<210>  5859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5859
uugugauuug uggcuugugg                                                   20


<210>  5860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5860
acaagccaca aaucacaacg                                                   20


<210>  5861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5861
agaucuuuga ggccaaaaug                                                   20


<210>  5862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5862
aagaucuuga gcuccacaag                                                   20


<210>  5863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5863
agucugcccc cgccuggccc                                                   20


<210>  5864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5864
gcuggggcca ggcgggggca                                                   20


<210>  5865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5865
ggaaaccucc uuggcaacgg                                                   20


<210>  5866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5866
uuggcaacgg cuaagggucu                                                   20


<210>  5867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5867
cagugacauu aacccagcca                                                   20


<210>  5868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5868
ggaauauuac auguguggaa                                                   20


<210>  5869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5869
cggugauguu aacacauccg                                                   20


<210>  5870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5870
caaaacaagg auauucaaaa                                                   20


<210>  5871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5871
auuauuugca ucaaguucug                                                   20


<210>  5872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5872
uguguuuuug uuucacaagc                                                   20


<210>  5873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5873
uuacccuacc cccagccaac                                                   20


<210>  5874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5874
cuccuuaccc uacccccagc                                                   20


<210>  5875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5875
ucccuccuua cccuaccccc                                                   20


<210>  5876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5876
uccuccuccc uccuuacccu                                                   20


<210>  5877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5877
cuucagguca gagauuagaa                                                   20


<210>  5878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5878
gaccugaagu gagacauuga                                                   20


<210>  5879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5879
gugugaacag ggcaccugcu                                                   20


<210>  5880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5880
ccuucucugg gcugugauuu                                                   20


<210>  5881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5881
gggcugugau uuccugcucc                                                   20


<210>  5882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5882
agcaccagcg ugcuucagca                                                   20


<210>  5883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5883
gucaaugcug aagcacgcug                                                   20


<210>  5884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5884
ucugucaaug cugaagcacg                                                   20


<210>  5885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5885
uucuguuggc acugaucggg                                                   20


<210>  5886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5886
agugccauag uccauggagu                                                   20


<210>  5887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5887
auggacuaug gcacuggagg                                                   20


<210>  5888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5888
auucuucugc cuugacauaa                                                   20


<210>  5889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5889
uauucuacuc uucucuugau                                                   20


<210>  5890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5890
ucucuugaug gucggcuggc                                                   20


<210>  5891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5891
ugauggucgg cuggcugacc                                                   20


<210>  5892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5892
uugcuucagu caggauggca                                                   20


<210>  5893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5893
cugucucauu cuucaacuac                                                   20


<210>  5894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5894
uucuucaacu acaccaccuc                                                   20


<210>  5895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5895
cgccuaagcc ucguucuucu                                                   20


<210>  5896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5896
uucuucuugg cccuucccca                                                   20


<210>  5897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5897
ccaaccccuu cccuccaucu                                                   20


<210>  5898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5898
aaccccuucc cuccaucuuu                                                   20


<210>  5899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5899
aucuuuccau ccuuccaagc                                                   20


<210>  5900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5900
uucagcccca guuccucucu                                                   20


<210>  5901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5901
cugaagcucc cccugauacc                                                   20


<210>  5902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5902
gaagcucccc cugauaccuu                                                   20


<210>  5903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5903
cccugauacc uuccaccccu                                                   20


<210>  5904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5904
cagaccuccc ugcucucuac                                                   20


<210>  5905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5905
cugcucucua cacaccugua                                                   20


<210>  5906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5906
cuacacaccu guagugcucc                                                   20


<210>  5907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5907
acacaccugu agugcuccca                                                   20


<210>  5908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5908
cagcauaugc caccagcuuu                                                   20


<210>  5909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5909
ccacucuugu aaaccugugg                                                   20


<210>  5910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5910
acucuuguaa accuguggga                                                   20


<210>  5911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5911
uguaaaccug ugggagggcc                                                   20


<210>  5912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5912
cacagguuua caagagugga                                                   20


<210>  5913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5913
ugugucugug cauuccaaag                                                   20


<210>  5914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5914
uaggcauucu uuggaaugca                                                   20


<210>  5915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5915
aagugcaaca cccucuuagg                                                   20


<210>  5916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5916
ccaaacaggc aaguauuuau                                                   20


<210>  5917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5917
aaccuaccag ucccucuucc                                                   20


<210>  5918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5918
uccaggcauc uagccuaugg                                                   20


<210>  5919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5919
uuuaaacaua caucuuuaua                                                   20


<210>  5920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5920
acaauagcag uagcaacaac                                                   20


<210>  5921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5921
caacaauagc aguagcaaca                                                   20


<210>  5922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5922
agauuuuugc uauuauaaac                                                   20


<210>  5923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5923
uccuucuggc cauuuggguu                                                   20


<210>  5924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5924
uaguuaugac uuuaugcugc                                                   20


<210>  5925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5925
aaacacuugg auauugaucc                                                   20


<210>  5926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5926
cguagguagu aggcagugaa                                                   20


<210>  5927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5927
agaaaauuac uuaacaucuc                                                   20


<210>  5928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5928
guuuccuuau cucucaaaug                                                   20


<210>  5929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5929
caaaugggga aaacagucau                                                   20


<210>  5930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5930
aauggggaaa acagucauau                                                   20


<210>  5931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5931
gaggacuggc acagggacua                                                   20


<210>  5932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5932
gaggcaauau gacuguuuuc                                                   20


<210>  5933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5933
uuuagucccu gugccagucc                                                   20


<210>  5934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5934
ggagagacaa auuaggagaa                                                   20


<210>  5935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5935
agaggaaacc acuguuaaca                                                   20


<210>  5936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5936
ccagaggaaa ccacuguuaa                                                   20


<210>  5937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5937
uaauuugucu cuccagagga                                                   20


<210>  5938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5938
uauuugucag uagcauggca                                                   20


<210>  5939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5939
gguagcaguu uguccuuaug                                                   20


<210>  5940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5940
gcaaccccac aacaugcuga                                                   20


<210>  5941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5941
auuuuucagc auguuguggg                                                   20


<210>  5942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5942
cuuucaccug gcaaaauccu                                                   20


<210>  5943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5943
ucuuccaaga caccuuccca                                                   20


<210>  5944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5944
agucugcagc auucucuccc                                                   20


<210>  5945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5945
cccuacuccc aacucagaga                                                   20


<210>  5946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5946
cuacucccaa cucagagaga                                                   20


<210>  5947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5947
caacucagag agauucucug                                                   20


<210>  5948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5948
gagagauucu cugcccuccc                                                   20


<210>  5949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5949
gaguugggag uagggagaga                                                   20


<210>  5950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5950
cugaguuggg aguagggaga                                                   20


<210>  5951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5951
gcccucccgc aucugggugg                                                   20


<210>  5952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5952
cgcaucuggg uggcucuccu                                                   20


<210>  5953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5953
ccuucuggug acucauguca                                                   20


<210>  5954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5954
uucuggugac ucaugucaug                                                   20


<210>  5955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5955
ugucaugauu uaacauaagc                                                   20


<210>  5956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5956
ggggccuugg guggugcuua                                                   20


<210>  5957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5957
acacucuggg gccuugggug                                                   20


<210>  5958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5958
uguucuccac acucuggggc                                                   20


<210>  5959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5959
cugccucagg uuucuguguc                                                   20


<210>  5960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5960
gccucagguu ucuguguccu                                                   20


<210>  5961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5961
gguuucugug uccuccacca                                                   20


<210>  5962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5962
accacaucuc augacaaucc                                                   20


<210>  5963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5963
ugacaauccc gucccacugg                                                   20


<210>  5964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5964
aggccucccc accauagccc                                                   20


<210>  5965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5965
ccaccauagc cccacacucu                                                   20


<210>  5966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5966
ccaccagguc cucucucuuu                                                   20


<210>  5967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5967
accagguccu cucucuuucu                                                   20


<210>  5968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5968
cucuuucugg ggaugcaguc                                                   20


<210>  5969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5969
cuuucugggg augcagucag                                                   20


<210>  5970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5970
uucuggggau gcagucagac                                                   20


<210>  5971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5971
gccagucuga cugcaucccc                                                   20


<210>  5972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5972
accuuuugcu cuccauugcu                                                   20


<210>  5973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5973
ccauugcuua cuuuuuuuuu                                                   20


<210>  5974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5974
auugcuuacu uuuuuuuuuu                                                   20


<210>  5975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5975
aaaaggaaaa aaaaaaaaaa                                                   20


<210>  5976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5976
aucucaaaaa ggaaaaaaaa                                                   20


<210>  5977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5977
gucaccaggc uggagugcag                                                   20


<210>  5978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5978
agccugguga cagaguaaga                                                   20


<210>  5979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5979
gcucacugca acucucaccu                                                   20


<210>  5980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5980
cugcaacucu caccucccag                                                   20


<210>  5981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5981
caccucccag gaucaaguga                                                   20


<210>  5982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5982
ccucccagga ucaagugauu                                                   20


<210>  5983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5983
caggaucaag ugauucuccu                                                   20


<210>  5984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5984
ugccucagcc ucccaaguag                                                   20


<210>  5985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5985
gccucccaag uagcugggac                                                   20


<210>  5986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5986
caaguagcug ggacuacagg                                                   20


<210>  5987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5987
gcuaauuuuu guauuuuuuu                                                   20


<210>  5988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5988
acuaaaaaaa uacaaaaauu                                                   20


<210>  5989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5989
aucucuugac cuugugaucc                                                   20


<210>  5990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5990
ugaccuugug auccacccgc                                                   20


<210>  5991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5991
gccucccaaa guacugggau                                                   20


<210>  5992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5992
caaaguacug ggauuacagg                                                   20


<210>  5993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5993
cgccuguaau cccaguacuu                                                   20


<210>  5994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5994
cuuuuguggc cacuuucccc                                                   20


<210>  5995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5995
augcuguuau cagcuugcuu                                                   20


<210>  5996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5996
cgcuauuccu ucaggccaac                                                   20


<210>  5997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5997
cuauuccuuc aggccaacuu                                                   20


<210>  5998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5998
ccucugcacc ccucauccug                                                   20


<210>  5999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  5999
gcaccccuca uccugugccu                                                   20


<210>  6000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6000
uccugugccu agcagaaaac                                                   20


<210>  6001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6001
gaauggguag agcuugucuc                                                   20


<210>  6002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6002
acccauucag aggguggcuu                                                   20


<210>  6003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6003
ucaacuggau cgcaaauucc                                                   20


<210>  6004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6004
gauugggcau gaguggagug                                                   20


<210>  6005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6005
ugcccaaucu gagaaaggaa                                                   20


<210>  6006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6006
acucaugccc aaucugagaa                                                   20


<210>  6007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6007
acuccacuca ugcccaaucu                                                   20


<210>  6008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6008
aagccuuugc uccacuccac                                                   20


<210>  6009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6009
acuccaagcc uuugcuccac                                                   20


<210>  6010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6010
gccuucccuc aacuccaagc                                                   20


<210>  6011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6011
cuccgccuuc ccucaacucc                                                   20


<210>  6012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6012
cuaacuuugu auggcaacac                                                   20


<210>  6013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6013
gauaagauga auuuucucaa                                                   20


<210>  6014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6014
aaagccaaua auuccacaug                                                   20


<210>  6015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6015
ucuaaaauua gagagaagug                                                   20


<210>  6016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6016
aauuuuagau gagccaugug                                                   20


<210>  6017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6017
cuaauuuuag augagccaug                                                   20


<210>  6018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6018
aauucccuaa gaaagucauu                                                   20


<210>  6019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6019
agggcauuuc ugucccugcc                                                   20


<210>  6020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6020
gccuggauuu guacaaauac                                                   20


<210>  6021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6021
ucaauuuccu uguuuagaaa                                                   20


<210>  6022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6022
auuuccuugu uuagaaacac                                                   20


<210>  6023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6023
aauuucaaua ggacuuuguu                                                   20


<210>  6024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6024
cagcuccucc agccccaacg                                                   20


<210>  6025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6025
gcuccuccag ccccaacgug                                                   20


<210>  6026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6026
uccagcccca acgugcuugc                                                   20


<210>  6027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6027
agccccaacg ugcuugccau                                                   20


<210>  6028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6028
uaaacagcug cagccuggac                                                   20


<210>  6029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6029
gcguuaggcc caucuguaag                                                   20


<210>  6030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6030
cugagcaggc cccgugcuac                                                   20


<210>  6031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6031
gggagugugg guccguguau                                                   20


<210>  6032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6032
aaccucugca uuccugcagg                                                   20


<210>  6033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6033
gcauuccugc agggguccuc                                                   20


<210>  6034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6034
ggguaacucu gccccccacc                                                   20


<210>  6035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6035
gccccccacc caguuaguga                                                   20


<210>  6036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6036
ggauugggug uuugguagcc                                                   20


<210>  6037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6037
ggcuaccaaa cacccaaucc                                                   20


<210>  6038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6038
gcuggccaua ggaaacucag                                                   20


<210>  6039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6039
caagaugagg uguggcacaa                                                   20


<210>  6040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6040
ucuugugaga uguuaugucu                                                   20


<210>  6041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6041
ccagccagcc ccaguuucca                                                   20


<210>  6042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6042
uccccauagu ucucaaaggu                                                   20


<210>  6043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6043
aagguuauag aacccccuuc                                                   20


<210>  6044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6044
uucagcaaua gucuucccug                                                   20


<210>  6045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6045
cccuauauug ucaacacauc                                                   20


<210>  6046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6046
guggaauacc ccauccaauu                                                   20


<210>  6047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6047
cacugacccu aaaaagaaag                                                   20


<210>  6048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6048
cugacccuaa aaagaaagcc                                                   20


<210>  6049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6049
ucaacauucc cauuuuaauu                                                   20


<210>  6050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6050
aagacaacaa uucauauuga                                                   20


<210>  6051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6051
ccaucaauau gaauuguugu                                                   20


<210>  6052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6052
uggaauaaug uccuuaaaaa                                                   20


<210>  6053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6053
cuuggaauaa uguccuuaaa                                                   20


<210>  6054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6054
gucaggugca guggacuuaa                                                   20


<210>  6055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6055
ugacaucucu gcccucauua                                                   20


<210>  6056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6056
gcccucauua aaaaagcaua                                                   20


<210>  6057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6057
uuaaaaaagc auaucacagu                                                   20


<210>  6058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6058
caugcaugca ugcucaacgc                                                   20


<210>  6059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6059
acgccaaaaa uccgagagga                                                   20


<210>  6060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6060
accaggggau aguaaaggcu                                                   20


<210>  6061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6061
ucagcagcac cacuuacgca                                                   20


<210>  6062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6062
gguagguaaa uggucccucc                                                   20


<210>  6063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6063
ugcagucuug uucacacugu                                                   20


<210>  6064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6064
gcaaauuaac agugugaaca                                                   20


<210>  6065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6065
aggacugugc aaacaccggu                                                   20


<210>  6066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6066
gauaagaaau ccacuagagu                                                   20


<210>  6067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6067
uuccaagauu cagaauugua                                                   20


<210>  6068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6068
gcaguuaugg aaaaugacua                                                   20


<210>  6069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6069
ccuagggacc aucagaacuu                                                   20


<210>  6070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6070
uagggaccau cagaacuugg                                                   20


<210>  6071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6071
ccaaacaccu ugagaacuuc                                                   20


<210>  6072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6072
aaacaccuug agaacuucau                                                   20


<210>  6073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6073
agguguuugg agagccuguu                                                   20


<210>  6074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6074
uugaucccuu aauacaucua                                                   20


<210>  6075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6075
gacaccuuca uugacuucau                                                   20


<210>  6076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6076
agggacuacc accaacuuag                                                   20


<210>  6077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6077
augugaacug gaaaagcuaa                                                   20


<210>  6078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6078
acuuaucaaa gagaaguaca                                                   20


<210>  6079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6079
uugauaagug gaguuaacau                                                   20


<210>  6080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6080
auuaugaaaa guagaaacca                                                   20


<210>  6081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6081
caauaucauu cauuuugguu                                                   20


<210>  6082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6082
gcugggguuu ccugaauuua                                                   20


<210>  6083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6083
uccacccaau augguaguug                                                   20


<210>  6084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6084
ugacuucccc uuucuuucau                                                   20


<210>  6085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6085
cuggccuccu gacuuccccu                                                   20


<210>  6086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6086
cagguccucc cuggccuccu                                                   20


<210>  6087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6087
cuggccuccc agguccuccc                                                   20


<210>  6088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6088
ucccuggccu cccagguccu                                                   20


<210>  6089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6089
uccucccugg ccucccaggu                                                   20


<210>  6090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6090
aauaaguaaa ucuguugaca                                                   20


<210>  6091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6091
uuacucuaau aaguaaaucu                                                   20


<210>  6092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6092
auuucaugcc aaaguuaggc                                                   20


<210>  6093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6093
agcguccugg uaaaggagac                                                   20


<210>  6094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6094
uuuaccagga cgcuggagaa                                                   20


<210>  6095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6095
agggucuguc uaccuuuugg                                                   20


<210>  6096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6096
ucuccagggu cugucuaccu                                                   20


<210>  6097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6097
uuacaccucu ucuccagggu                                                   20


<210>  6098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6098
aguccugacu aauugaaagu                                                   20


<210>  6099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6099
ucauucaagg gauuuucccc                                                   20


<210>  6100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6100
gugagcaauc cccaccuauu                                                   20


<210>  6101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6101
cugagcucuu cauucaaggg                                                   20


<210>  6102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6102
cacucuuguu cuuagucacu                                                   20


<210>  6103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6103
uguucuuagu cacuugagcc                                                   20


<210>  6104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6104
agugacuaag aacaagagug                                                   20


<210>  6105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6105
ugugcgugga ugcagaaaau                                                   20


<210>  6106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6106
cacaguuuau aaaacacaac                                                   20


<210>  6107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6107
acugcuccca caguuuauaa                                                   20


<210>  6108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6108
uaguaacaaa ugccaguucu                                                   20


<210>  6109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6109
auaccacuug accucuuaaa                                                   20


<210>  6110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6110
uaaacaaggc ccuacaaaua                                                   20


<210>  6111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6111
auuucuuuuu uuacaauggg                                                   20


<210>  6112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6112
uaugacuagc cugauggagc                                                   20


<210>  6113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6113
aucaggcuag ucauaagaga                                                   20


<210>  6114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6114
uugauggcau ccaaaucagu                                                   20


<210>  6115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6115
gcauggccuu caggaucaau                                                   20


<210>  6116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6116
ccuggguucu gccuuuucca                                                   20


<210>  6117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6117
gcucgccugg guucugccuu                                                   20


<210>  6118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6118
aagcacagcu gcugcagacg                                                   20


<210>  6119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6119
ggcagcccuc ucugcauaaa                                                   20


<210>  6120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6120
cugcauaaag aacauggaau                                                   20


<210>  6121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6121
gcauaaagaa cauggaaucg                                                   20


<210>  6122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6122
gggaaaugua ggcacgauuc                                                   20


<210>  6123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6123
gcccuagcug ucccucuaca                                                   20


<210>  6124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6124
acaugagagg gagagggaug                                                   20


<210>  6125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6125
uguagaggga cagcuagggc                                                   20


<210>  6126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6126
cauguagagg gacagcuagg                                                   20


<210>  6127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6127
cucucaugua gagggacagc                                                   20


<210>  6128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6128
cccucucaug uagagggaca                                                   20


<210>  6129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6129
gacagccagc cauuaauuac                                                   20


<210>  6130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6130
cugacagcca gccauuaauu                                                   20


<210>  6131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6131
aaaaugacuc ucugacagcc                                                   20


<210>  6132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6132
gccguugaag gcuccauauu                                                   20


<210>  6133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6133
auauuaaagg ccggauccca                                                   20


<210>  6134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6134
cucucuaaau gguaggagug                                                   20


<210>  6135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6135
cuaaauggua ggagugacgu                                                   20


<210>  6136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6136
aaaugguagg agugacgugg                                                   20


<210>  6137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6137
uaccauuuag agagggaguu                                                   20


<210>  6138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6138
cuucuugccc caggugccca                                                   20


<210>  6139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6139
ugcuuccccc ucccuucuug                                                   20


<210>  6140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6140
uucgccaucu ccugcuuccc                                                   20


<210>  6141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6141
aaaccuccuu cgccaucucc                                                   20


<210>  6142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6142
acuuccccuc uaaaccuccu                                                   20


<210>  6143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6143
gaagucaguu ugccguaaug                                                   20


<210>  6144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6144
ugucagaacu cugaagucag                                                   20


<210>  6145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6145
cuuuccgccc ccuaauaagc                                                   20


<210>  6146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6146
uaaaauauac auagcagauc                                                   20


<210>  6147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6147
cugauuuuau cuuuguuacu                                                   20


<210>  6148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6148
ccagccauuc uuuugguacu                                                   20


<210>  6149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6149
auccauccuc cauccccucu                                                   20


<210>  6150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6150
ccauccaucc uccauccccu                                                   20


<210>  6151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6151
aucccucucc auccauccuc                                                   20


<210>  6152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6152
uccaucccuc uccauccauc                                                   20


<210>  6153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6153
agcuggcuca uuuccaugaa                                                   20


<210>  6154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6154
uuuccaugaa ggugggcagc                                                   20


<210>  6155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6155
cucugccugc cgccagugcc                                                   20


<210>  6156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6156
gccugccgcc agugccacca                                                   20


<210>  6157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6157
guugguggca cuggcggcag                                                   20


<210>  6158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6158
cgcuagguag uuaaccugca                                                   20


<210>  6159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6159
aaauggugca uaugguaacc                                                   20


<210>  6160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6160
aacaauucaa gucgggugaa                                                   20


<210>  6161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6161
cggcucguuc uauuugugca                                                   20


<210>  6162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6162
uucuauuugu gcaaguccua                                                   20


<210>  6163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6163
cugcucaugg cgauccucca                                                   20


<210>  6164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6164
gcucauggcg auccuccaga                                                   20


<210>  6165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6165
uggcgauccu ccagaauguu                                                   20


<210>  6166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6166
agaauguuug ccuagaaucg                                                   20


<210>  6167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6167
gaauuguuaa uucugaaguu                                                   20


<210>  6168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6168
accaggaagc uuucccagau                                                   20


<210>  6169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6169
caauaggaau aaauuacuuc                                                   20


<210>  6170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6170
auaggaauaa auuacuuccc                                                   20


<210>  6171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6171
ugugccuucc cuaauagaua                                                   20


<210>  6172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6172
uaucuauuag ggaaggcaca                                                   20


<210>  6173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6173
aggaagccuc uuaucuauua                                                   20


<210>  6174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6174
auagaaagcc cacaccccgg                                                   20


<210>  6175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6175
auaaaucuaa gcagaauuga                                                   20


<210>  6176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6176
guucuaauua aagugggcaa                                                   20


<210>  6177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6177
uccgguucua guagggcugg                                                   20


<210>  6178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6178
accagcuugc uagcucuucc                                                   20


<210>  6179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6179
ugacuccuuu cucccccacc                                                   20


<210>  6180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6180
uuucuccccc acccccaucc                                                   20


<210>  6181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6181
cccaccccca uccugaggac                                                   20


<210>  6182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6182
ggaugggggu gggggagaaa                                                   20


<210>  6183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6183
uuauggacac aaguguuuca                                                   20


<210>  6184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6184
gcuggcucuu uauggacaca                                                   20


<210>  6185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6185
cauagaccca cuacugugca                                                   20


<210>  6186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6186
caaaacucac ccuuucacau                                                   20


<210>  6187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6187
gaggucauga aguucaaugg                                                   20


<210>  6188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6188
gagugaaugu gaaaggguga                                                   20


<210>  6189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6189
auugaacuuc augaccucag                                                   20


<210>  6190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6190
uucuaccccu uuguuuucuc                                                   20


<210>  6191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6191
uauuuggcau gccaguggcc                                                   20


<210>  6192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6192
aaaauauuaa guagaggguc                                                   20


<210>  6193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6193
acuuaauauu uuggaggcac                                                   20


<210>  6194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6194
cuaagugcua uauuacugac                                                   20


<210>  6195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6195
agauggaguc uugcucuguc                                                   20


<210>  6196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6196
aggaaagaua ucugugauau                                                   20


<210>  6197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6197
ucuguccuuu gcaacauacu                                                   20


<210>  6198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6198
gaaugaauca cagguacuuu                                                   20


<210>  6199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6199
ucaacuuaug gaauagugaa                                                   20


<210>  6200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6200
acuuauggaa uagugaagac                                                   20


<210>  6201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6201
acaguagaca uugcauuuga                                                   20


<210>  6202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6202
uaauggcuac augaaggucc                                                   20


<210>  6203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6203
cacgguuauu auuuuuguuu                                                   20


<210>  6204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6204
ugaucccuca cacgguuauu                                                   20


<210>  6205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6205
aaauauccau aaugcucugu                                                   20


<210>  6206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6206
gucuuuauga ugcaaaagaa                                                   20


<210>  6207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6207
uuaaagaacu auuauuuuuu                                                   20


<210>  6208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6208
acaugaaaca ucuuaauuug                                                   20


<210>  6209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6209
gugucaaugg aaagcuaccu                                                   20


<210>  6210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6210
uucuagauau uuucauuuca                                                   20


<210>  6211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6211
cuguggccau uccagggucc                                                   20


<210>  6212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6212
cccuguggcc auuccagggu                                                   20


<210>  6213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6213
cucccugugg ccauuccagg                                                   20


<210>  6214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6214
guaucucucu cccuguggcc                                                   20


<210>  6215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6215
uucuuccugg cuccguaucu                                                   20


<210>  6216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6216
aaucuuggcu cugcuacaga                                                   20


<210>  6217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6217
ggucaaagcu gcaaguuguu                                                   20


<210>  6218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6218
ucaaagauca uacacagcgg                                                   20


<210>  6219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6219
uucuucuuaa cucuucaaag                                                   20


<210>  6220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6220
cauuguucca guggaucaug                                                   20


<210>  6221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6221
uuugggaaug gauucuggcc                                                   20


<210>  6222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6222
gcgucucaca gaaaagagug                                                   20


<210>  6223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6223
cagaaaagag uguaccuaaa                                                   20


<210>  6224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6224
uuucugugag acgcagaggu                                                   20


<210>  6225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6225
uccuaggaau uggcuuuuua                                                   20


<210>  6226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6226
uaggaauugg cuuuuuacca                                                   20


<210>  6227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6227
uaagacuagc ucuuuaagcu                                                   20


<210>  6228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6228
uuaagcuguu acagccacuu                                                   20


<210>  6229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6229
gguugcauau aaaaguggcu                                                   20


<210>  6230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6230
uauggugugu uaaaagauuu                                                   20


<210>  6231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6231
uuugcugacc ucuuccucau                                                   20


<210>  6232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6232
uccucaucuc aguguuuuug                                                   20


<210>  6233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6233
ucucaguguu uuuggucuca                                                   20


<210>  6234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6234
guguuuuugg ucucacuucu                                                   20


<210>  6235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6235
uucuuccuau cguuucccug                                                   20


<210>  6236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6236
ucucccaggu gaaaguccuc                                                   20


<210>  6237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6237
caggugaaag uccucgucag                                                   20


<210>  6238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6238
ucagcaccug aaucauggag                                                   20


<210>  6239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6239
ugccaagaaa aguaugggua                                                   20


<210>  6240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6240
gcucaugcca agaaaaguau                                                   20


<210>  6241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6241
cagguuuuug caagucugcc                                                   20


<210>  6242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6242
gguuuuugca agucugccug                                                   20


<210>  6243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6243
gggugggcug agauuucugu                                                   20


<210>  6244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6244
uccuugacuc ugggugggcu                                                   20


<210>  6245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6245
uuucugcaau aacccucuuc                                                   20


<210>  6246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6246
ccaaguaucc uuccaacuua                                                   20


<210>  6247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6247
aagugcugug cuugggccac                                                   20


<210>  6248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6248
gagggucaac gcaguugccc                                                   20


<210>  6249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6249
gaggauauug aacuacagca                                                   20


<210>  6250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6250
caacaaauca gaaaaacagg                                                   20


<210>  6251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6251
uuugauccuc acaacaaauc                                                   20


<210>  6252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6252
guucugugua auucuuguuu                                                   20


<210>  6253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6253
aaacuaccau ccuagcucau                                                   20


<210>  6254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6254
uauuuucuag gaagccuaua                                                   20


<210>  6255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6255
uaaagccuuc auuguuucug                                                   20


<210>  6256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6256
cgcccagcca ucuaaacaca                                                   20


<210>  6257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6257
ucaccagccc ucacaagcgc                                                   20


<210>  6258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6258
ccagcccuca caagcgcauu                                                   20


<210>  6259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6259
caagcgcauu ccacgcagga                                                   20


<210>  6260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6260
uucuaaacau gcaacuacag                                                   20


<210>  6261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6261
gguuuuucua uaaacagauu                                                   20


<210>  6262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6262
cuucaggggc cacggagggg                                                   20


<210>  6263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6263
guggccccug aagggagcuc                                                   20


<210>  6264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6264
accccuccgu ggccccugaa                                                   20


<210>  6265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6265
gccaaccuuc cuccaccccu                                                   20


<210>  6266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6266
ucaaauagag cagcugcacu                                                   20


<210>  6267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6267
auuugaagag gaaguugggg                                                   20


<210>  6268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6268
uuuugcugau uuuuuuuuuu                                                   20


<210>  6269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6269
gucucagcca aggcgccuac                                                   20


<210>  6270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6270
gccaaggcgc cuacuucggg                                                   20


<210>  6271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6271
cagggguugc ccgaaguagg                                                   20


<210>  6272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6272
ugcccugucc cccaccuaga                                                   20


<210>  6273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6273
aaagaaacau auuaaugccu                                                   20


<210>  6274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6274
gaaguggcac caggaagcaa                                                   20


<210>  6275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6275
gacuugcuuc cuggugccac                                                   20


<210>  6276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6276
cagaaggugu aagcggaaac                                                   20


<210>  6277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6277
uucuggacaa uguccaaacc                                                   20


<210>  6278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6278
ugucuaugca cacacacaca                                                   20


<210>  6279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6279
ccugucuaug cacacacaca                                                   20


<210>  6280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6280
uucucuccug ucuaugcaca                                                   20


<210>  6281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6281
ccuucucucc ugucuaugca                                                   20


<210>  6282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6282
accucuccuu cucuccuguc                                                   20


<210>  6283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6283
aucucuaccu cuccuucucu                                                   20


<210>  6284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6284
gaauaaauac uggaggggua                                                   20


<210>  6285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6285
aguauuuauu cagagaaauu                                                   20


<210>  6286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6286
uaccccucca guauuuauuc                                                   20


<210>  6287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6287
ucuccuaccc cuccaguauu                                                   20


<210>  6288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6288
uuaauugcuu gacauauuuc                                                   20


<210>  6289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6289
ucuauaagaa uucacuuuca                                                   20


<210>  6290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6290
auaagaauuc acuuucauag                                                   20


<210>  6291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6291
uucacccaaa uguguaugca                                                   20


<210>  6292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6292
acagcaacau cuuuugugcu                                                   20


<210>  6293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6293
aggaagaugu uuauuugaag                                                   20


<210>  6294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6294
auuggguuaa ugaauguggc                                                   20


<210>  6295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6295
cuaacggggc uguucaagac                                                   20


<210>  6296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6296
cguggaacac ugaaguuaca                                                   20


<210>  6297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6297
guuuacucac guggaacacu                                                   20


<210>  6298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6298
accaccgugc cucaguuuac                                                   20


<210>  6299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6299
ccaccaccgu gccucaguuu                                                   20


<210>  6300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6300
gaaugaggua uaggaucugg                                                   20


<210>  6301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6301
uucugagaaa aguuacucuc                                                   20


<210>  6302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6302
uuucauuugg ggcaaagaca                                                   20


<210>  6303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6303
uugguuuugg aacuuaucug                                                   20


<210>  6304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6304
aaacacugac accaauuuuc                                                   20


<210>  6305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6305
aacacuggga uaggaagguu                                                   20


<210>  6306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6306
uuccaauaag cgaguagccg                                                   20


<210>  6307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6307
cuuauuggaa ugagucaaag                                                   20


<210>  6308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6308
cuuccccacc ucucauccca                                                   20


<210>  6309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6309
uucuuucugg aagagaugcu                                                   20


<210>  6310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6310
ucauucuuuc uggaagagau                                                   20


<210>  6311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6311
uaucuguuca cuuaacaagu                                                   20


<210>  6312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6312
uggaucugaa uggcaaggcu                                                   20


<210>  6313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6313
gaaccacaau uacaaucgcc                                                   20


<210>  6314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6314
ucuuuggccc agguuguuga                                                   20


<210>  6315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6315
uuggcccagg uuguugaguu                                                   20


<210>  6316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6316
acaaccuggg ccaaagagga                                                   20


<210>  6317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6317
auuauuguuu auaaagaaaa                                                   20


<210>  6318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6318
uuguugcauc aggcacaaac                                                   20


<210>  6319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6319
caaggugcau gcucucagcc                                                   20


<210>  6320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6320
uauucuagaa uggauggaca                                                   20


<210>  6321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6321
cauauucuag aauggaugga                                                   20


<210>  6322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6322
auuuauagau gagaaaacug                                                   20


<210>  6323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6323
augacuuaac ugagucacaa                                                   20


<210>  6324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6324
guuaagucau ggagguccag                                                   20


<210>  6325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6325
gacugaagac agacgucugc                                                   20


<210>  6326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6326
ugaucagaag gcaagcagac                                                   20


<210>  6327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6327
uucuaggagc aaugacagga                                                   20


<210>  6328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6328
uagaaggagg cccagacagg                                                   20


<210>  6329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6329
ugucauugcu ccuagaagga                                                   20


<210>  6330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6330
uuuaguucuu cuaacagccc                                                   20


<210>  6331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6331
acuauguccu uucaacuguu                                                   20


<210>  6332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6332
uugaacuuga ccuucaaccg                                                   20


<210>  6333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6333
ugcauuuggu aauaauauau                                                   20


<210>  6334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6334
gagagacccu aagaugccag                                                   20


<210>  6335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6335
gaguuuuaac cagugggcca                                                   20


<210>  6336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6336
cagaguuuua accagugggc                                                   20


<210>  6337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6337
aaaaaaaaaa aaagaaaaag                                                   20


<210>  6338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6338
gacacugaua agcagguccc                                                   20


<210>  6339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6339
gcuccuaacu gcggacucca                                                   20


<210>  6340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6340
uaacugcgga cuccagagag                                                   20


<210>  6341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6341
agagagcuua guaagaacuu                                                   20


<210>  6342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6342
ggaguccgca guuaggagca                                                   20


<210>  6343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6343
cuggaguccg caguuaggag                                                   20


<210>  6344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6344
ccauguugcc caggcugguc                                                   20


<210>  6345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6345
aacuccugac cucaagagau                                                   20


<210>  6346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6346
ugaccucaag agauccucca                                                   20


<210>  6347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6347
agagauccuc cagccucagc                                                   20


<210>  6348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6348
ugaggucagg aguuugagac                                                   20


<210>  6349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6349
agccucagcc ccucaaagug                                                   20


<210>  6350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6350
gccccucaaa gugcugggau                                                   20


<210>  6351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6351
aagugcuggg auuauaggca                                                   20


<210>  6352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6352
uaaagagacu ccucccucuc                                                   20


<210>  6353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6353
uuaugagcca aaagaauaaa                                                   20


<210>  6354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6354
ucccucucau uaaaauacaa                                                   20


<210>  6355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6355
cucucauuaa aauacaaauc                                                   20


<210>  6356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6356
cauuaaaaua caaaucuugg                                                   20


<210>  6357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6357
uuaaaauaca aaucuuggaa                                                   20


<210>  6358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6358
aguaacgaau uagcagaaaa                                                   20


<210>  6359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6359
uuuccauuuu cugcuaauuc                                                   20


<210>  6360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6360
guagagacuu ggcaauaccc                                                   20


<210>  6361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6361
aucugugggg cugucuuucu                                                   20


<210>  6362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6362
agccuagacu cuuuaaucca                                                   20


<210>  6363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6363
uaacaauagc aguacaucaa                                                   20


<210>  6364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6364
caaauuagua gccagcugau                                                   20


<210>  6365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6365
gguuugauaa uucacuagaa                                                   20


<210>  6366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6366
gaaucauucu agugaauuau                                                   20


<210>  6367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6367
ggaaggcgcu augcuuguga                                                   20


<210>  6368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6368
uuugaaguuu auuuccacuc                                                   20


<210>  6369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6369
uauguuaugu gcuugaaccc                                                   20


<210>  6370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6370
guacagucuc auauguuaug                                                   20


<210>  6371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6371
caguacaguc ucauauguua                                                   20


<210>  6372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6372
caucaagagc ucuggggauc                                                   20


<210>  6373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6373
ugaugugagc ccgcaggcuu                                                   20


<210>  6374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6374
ggggauccaa uccacuccag                                                   20


<210>  6375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6375
agagcaucug gggaaaagcc                                                   20


<210>  6376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6376
ggaguggauu ggauccccag                                                   20


<210>  6377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6377
auuuccaaac cucuggauug                                                   20


<210>  6378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6378
ggauugagac aucucuuaga                                                   20


<210>  6379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6379
auccagaggu uuggaaauug                                                   20


<210>  6380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6380
uagaacuggg ggaagccaag                                                   20


<210>  6381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6381
ugauuagaag cuuggcuucc                                                   20


<210>  6382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6382
acguucugac cacuccugau                                                   20


<210>  6383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6383
gcccgcuucc cggucccagc                                                   20


<210>  6384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6384
uccgcccgcu ucccgguccc                                                   20


<210>  6385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6385
ccuccgcccg cuucccgguc                                                   20


<210>  6386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6386
gcuggcacac acagcaugcc                                                   20


<210>  6387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6387
ugugcuccga ccuaaacaau                                                   20


<210>  6388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6388
gaccuaaaca augagcguaa                                                   20


<210>  6389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6389
uuguuuaggu cggagcacag                                                   20


<210>  6390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6390
acaggguccu gcaggagguc                                                   20


<210>  6391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6391
ugcaggaccc uguggagggc                                                   20


<210>  6392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6392
gaaacaagac cuccugcagg                                                   20


<210>  6393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6393
guuuaaccag agcagaccca                                                   20


<210>  6394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6394
gguuaaacag aggccccccu                                                   20


<210>  6395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6395
gcggggcaaa guugacauac                                                   20


<210>  6396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6396
guuguucuag aauuucaaac                                                   20


<210>  6397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6397
ggacaaucug cuucuucuua                                                   20


<210>  6398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6398
cuuuuguucu ucaauaaauc                                                   20


<210>  6399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6399
ucuuuuucuu ucccucacuu                                                   20


<210>  6400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6400
gauaauucuc uucuuuuucu                                                   20


<210>  6401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6401
cacauacuuc ccuuuccucc                                                   20


<210>  6402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6402
ugucuggccu aaggagaaca                                                   20


<210>  6403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6403
uuaggccaga caggaggaaa                                                   20


<210>  6404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6404
cuccccaacg gaaaggccuc                                                   20


<210>  6405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6405
ccaacggaaa ggccucaaaa                                                   20


<210>  6406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6406
aaacacugac auuuugcuuu                                                   20


<210>  6407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6407
gaaaaagcaa aaugucagug                                                   20


<210>  6408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6408
cuggaagaaa gcaggcggcg                                                   20


<210>  6409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6409
cccugacccu gccgccgccu                                                   20


<210>  6410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6410
cccccugacc cugccgccgc                                                   20


<210>  6411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6411
cucccccuga cccugccgcc                                                   20


<210>  6412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6412
ccucuucccu ucugacucac                                                   20


<210>  6413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6413
aaagccaaau uccagccuug                                                   20


<210>  6414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6414
caaaguaaaa gaauaguaac                                                   20


<210>  6415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6415
gaguaagagc cagaacucuu                                                   20


<210>  6416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6416
gagccuuccu accagucacc                                                   20


<210>  6417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6417
uacucagagc cuuccuacca                                                   20


<210>  6418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6418
uuggccucag guuuuuccca                                                   20


<210>  6419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6419
gguuuuuccc auguaaauuc                                                   20


<210>  6420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6420
gcugcgcauu ggaaaugcca                                                   20


<210>  6421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6421
agcccugauc uauugggaau                                                   20


<210>  6422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6422
gaguauuugc uuguaguugc                                                   20


<210>  6423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6423
gagaucccuc uagcccugau                                                   20


<210>  6424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6424
guucugccca agaagcaauu                                                   20


<210>  6425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6425
gcuuccuacc aggugacccc                                                   20


<210>  6426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6426
cugcuuccua ccaggugacc                                                   20


<210>  6427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6427
cucugcuucc uaccagguga                                                   20


<210>  6428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6428
augguaaaug auucucucuc                                                   20


<210>  6429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6429
gauauacuua cuggcagggg                                                   20


<210>  6430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6430
ccugccagua aguauaucug                                                   20


<210>  6431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6431
uucuugauag gaaaggauga                                                   20


<210>  6432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6432
ccuucuugau aggaaaggau                                                   20


<210>  6433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6433
ggcagggaag uccucuccuu                                                   20


<210>  6434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6434
gagagauaca uacuccaggg                                                   20


<210>  6435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6435
gaguacuagg caacgagcag                                                   20


<210>  6436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6436
cugaguacua ggcaacgagc                                                   20


<210>  6437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6437
agggccaggu ggugccacgc                                                   20


<210>  6438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6438
ggcagaagga uggguaacua                                                   20


<210>  6439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6439
ugaacugaac uggacaguuu                                                   20


<210>  6440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6440
cucugauugg cccaaggauu                                                   20


<210>  6441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6441
gauuggccca aggauuggca                                                   20


<210>  6442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6442
ggggcacucu gugaacagag                                                   20


<210>  6443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6443
gugaacagag cugaugagaa                                                   20


<210>  6444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6444
guucacagag ugccccugag                                                   20


<210>  6445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6445
ucagcucugu ucacagagug                                                   20


<210>  6446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6446
cucuaugagc cccuccaacu                                                   20


<210>  6447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6447
cuaugagccc cuccaacuaa                                                   20


<210>  6448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6448
augagccccu ccaacuaaaa                                                   20


<210>  6449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6449
uagagagagu cuguucucau                                                   20


<210>  6450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6450
aacuaaaagc ugccccuacc                                                   20


<210>  6451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6451
cuuuacucau cuuuacaaug                                                   20


<210>  6452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6452
uuacucaucu uuacaauggg                                                   20


<210>  6453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6453
ucuuuacaau ggggauagug                                                   20


<210>  6454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6454
ucagacuguu uuaagaauua                                                   20


<210>  6455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6455
gacuguuuua agaauuaagu                                                   20


<210>  6456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6456
gaaaauugua cucugugaaa                                                   20


<210>  6457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6457
gugaaauaag ucaggaucug                                                   20


<210>  6458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6458
cugggaaaua gcuagcagcu                                                   20


<210>  6459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6459
uaguggcaaa uuccagacuu                                                   20


<210>  6460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6460
uuuauguuuu gauuuaugaa                                                   20


<210>  6461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6461
aggcacauga acaaaaauga                                                   20


<210>  6462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6462
ggggccaaau gccugacuug                                                   20


<210>  6463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6463
agauuuaucu accccucugg                                                   20


<210>  6464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6464
gcacugggac ccaaagguca                                                   20


<210>  6465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6465
agaauccccu uucuuuuauu                                                   20


<210>  6466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6466
gaucuucuga gagccuagga                                                   20


<210>  6467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6467
gaagaucuga gguaggcugu                                                   20


<210>  6468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6468
cagaagaucu gagguaggcu                                                   20


<210>  6469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6469
gcauuucuag cuuccaauac                                                   20


<210>  6470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6470
uuuuugcucg aggcugggaa                                                   20


<210>  6471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6471
aggcugggaa caugugagag                                                   20


<210>  6472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6472
agcaaaaaug agguaucugu                                                   20


<210>  6473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6473
guuuccuacc aucuauacag                                                   20


<210>  6474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6474
agccucaguu uccuaccauc                                                   20


<210>  6475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6475
cuagccucag uuuccuacca                                                   20


<210>  6476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6476
gcccuuuacc acugugucac                                                   20


<210>  6477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6477
ucauuuccau cuucagguca                                                   20


<210>  6478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6478
guccaaggau uuaguuggcu                                                   20


<210>  6479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6479
cuguccaagg auuuaguugg                                                   20


<210>  6480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6480
gguccucucu guccaaggau                                                   20


<210>  6481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6481
accuugaguc accuugcagu                                                   20


<210>  6482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6482
gugcuuggcu ggaagccuuu                                                   20


<210>  6483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6483
aagcaagauc acaugaagau                                                   20


<210>  6484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6484
aaaaaaaaaa aaaaaagaaa                                                   20


<210>  6485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6485
uauugauccu gggacuauga                                                   20


<210>  6486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6486
aaaaagucca aauuuaguau                                                   20


<210>  6487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6487
ugcaaaggac aagcuuccuc                                                   20


<210>  6488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6488
uccauugaaa ggaaaggaag                                                   20


<210>  6489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6489
auugaaagga aaggaaggga                                                   20


<210>  6490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6490
cuuccuuucc uuucaaugga                                                   20


<210>  6491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6491
caggccagca gcugagauaa                                                   20


<210>  6492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6492
cggaagguga gagagggaga                                                   20


<210>  6493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6493
ccuuccguga ggcaggaagc                                                   20


<210>  6494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6494
caccuuccgu gaggcaggaa                                                   20


<210>  6495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6495
cucaccuucc gugaggcagg                                                   20


<210>  6496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6496
cucucucacc uuccgugagg                                                   20


<210>  6497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6497
cccucucuca ccuuccguga                                                   20


<210>  6498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6498
cucucccucu cucaccuucc                                                   20


<210>  6499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6499
gcauucgugg caguuauuca                                                   20


<210>  6500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6500
ccgcauucgu ggcaguuauu                                                   20


<210>  6501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6501
uuugauaaau accaugcagc                                                   20


<210>  6502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6502
cccuggugga gcauucuagg                                                   20


<210>  6503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6503
accagggcga gaccaucauc                                                   20


<210>  6504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6504
guaaacaucu gacccuagaa                                                   20


<210>  6505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6505
uuggugacac cugaaaauua                                                   20


<210>  6506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6506
caagccacgc aaaagcaggu                                                   20


<210>  6507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6507
uuuucaacau caaauuugcu                                                   20


<210>  6508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6508
gcaaauuuga uguugaaaaa                                                   20


<210>  6509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6509
ccuaaaucuc agcaaauuug                                                   20


<210>  6510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6510
caggucccac uguuuguccc                                                   20


<210>  6511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6511
cugaucacuc acagguccca                                                   20


<210>  6512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6512
cccugaucac ucacaggucc                                                   20


<210>  6513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6513
cacugaccag caagucaagc                                                   20


<210>  6514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6514
guggguagcc cuggccaucc                                                   20


<210>  6515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6515
gcugguccug ugugguggaa                                                   20


<210>  6516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6516
cucuggguua aaugugaaug                                                   20


<210>  6517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6517
cuggguuaaa ugugaauggc                                                   20


<210>  6518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6518
ggguuaaaug ugaauggcuc                                                   20


<210>  6519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6519
gaaauacaug cuagaaguuc                                                   20


<210>  6520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6520
ggguguggaa auuccauuuu                                                   20


<210>  6521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6521
ccacacccca gugguucauc                                                   20


<210>  6522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6522
aauacuuucu ccccacaccc                                                   20


<210>  6523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6523
guuucugggc caguugaacu                                                   20


<210>  6524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6524
guuggauccu cuguuuagug                                                   20


<210>  6525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6525
guuuaguguc ucaaaagcca                                                   20


<210>  6526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6526
aaagccaaaa ucaggguauc                                                   20


<210>  6527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6527
ucuagcuugu ccagguugcu                                                   20


<210>  6528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6528
agccacaaga aaccgaauuc                                                   20


<210>  6529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6529
gauaucauau guaaccuuga                                                   20


<210>  6530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6530
agacaucuca gauaucauau                                                   20


<210>  6531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6531
cgacaaggag caguugacag                                                   20


<210>  6532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6532
uugucgugag auucccaccu                                                   20


<210>  6533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6533
cuugcugguu ugcuuuuagc                                                   20


<210>  6534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6534
uguuuuagcu gaagaacguu                                                   20


<210>  6535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6535
auuuucuuuu cuuaacguuc                                                   20


<210>  6536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6536
uucgagguac uguuuacuga                                                   20


<210>  6537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6537
aaagagaacu ccauuuucuu                                                   20


<210>  6538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6538
guaaacagua ccucgaaaga                                                   20


<210>  6539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6539
uuuugcaccu caguaaacag                                                   20


<210>  6540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6540
cauuuugcac cucaguaaac                                                   20


<210>  6541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6541
ugguuucuug uguuuggguc                                                   20


<210>  6542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6542
ugcuggaccc aaacacaaga                                                   20


<210>  6543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6543
acuccugcug gacccaaaca                                                   20


<210>  6544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6544
caacuccugc uggacccaaa                                                   20


<210>  6545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6545
gaauggccau gcuggggggu                                                   20


<210>  6546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6546
aauguguaaa gucuugcaca                                                   20


<210>  6547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6547
acaaaccuug cuggcuuccu                                                   20


<210>  6548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6548
gcauuaauua acuucaggaa                                                   20


<210>  6549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6549
acucagcauu aauuaacuuc                                                   20


<210>  6550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6550
gagcaaagac uccacauuuu                                                   20


<210>  6551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6551
gagaaagccu gaucaguuuu                                                   20


<210>  6552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6552
acauuuuacc cauaaagcca                                                   20


<210>  6553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6553
cagcuaggcc ugaccugcau                                                   20


<210>  6554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6554
guaccuccca gcuaggccug                                                   20


<210>  6555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6555
uucugguguu ucccuucugg                                                   20


<210>  6556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6556
ccgaugggcc cuuggggcac                                                   20


<210>  6557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6557
aagucagucu guuuuuguac                                                   20


<210>  6558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6558
ucuaucucgc ccccaccccc                                                   20


<210>  6559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6559
aucucgcccc cacccccuac                                                   20


<210>  6560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6560
cccccacccc cuacuccugc                                                   20


<210>  6561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6561
ugcccaaguu acauuauggg                                                   20


<210>  6562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6562
cauauuuccu aaaaggucca                                                   20


<210>  6563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6563
cuuuccuuug gaaaaagccc                                                   20


<210>  6564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6564
uaauaucuug auccaagguu                                                   20


<210>  6565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6565
gagccuggug cuguagccua                                                   20


<210>  6566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6566
gagaaaaccu uggaucaaga                                                   20


<210>  6567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6567
uuguucaagc aaccccuuug                                                   20


<210>  6568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6568
gcaacgggca gugaggccuc                                                   20


<210>  6569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6569
cugcccguug cugaggccug                                                   20


<210>  6570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6570
gcucccaggc ccuggacagc                                                   20


<210>  6571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6571
caggcccugg acagccucca                                                   20


<210>  6572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6572
agaacauccg ggucacuccu                                                   20


<210>  6573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6573
uaagaaucca ggauccagac                                                   20


<210>  6574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6574
ugauaugugu guacuggguc                                                   20


<210>  6575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6575
gauuucccac aucaggaagg                                                   20


<210>  6576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6576
caccuguaau cccagcacuu                                                   20


<210>  6577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6577
aucguaaaua aauaaagucu                                                   20


<210>  6578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6578
aagaauauag acuuuauuua                                                   20


<210>  6579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6579
uuuuuuuguu uuuguuuuug                                                   20


<210>  6580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6580
cgaaauuacu uuaaucugcu                                                   20


<210>  6581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6581
aaauuacuuu aaucugcucu                                                   20


<210>  6582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6582
guuaaacagc ugacugauca                                                   20


<210>  6583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6583
gaaaggccuu ccuugacccc                                                   20


<210>  6584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6584
auguguccuu caguuuccag                                                   20


<210>  6585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6585
acuguucacc uguuuaacuc                                                   20


<210>  6586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6586
uccuccacug uucaccuguu                                                   20


<210>  6587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6587
aaagcucuuc cuccacuguu                                                   20


<210>  6588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6588
auggugccug ccucaaaagc                                                   20


<210>  6589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6589
ggacccuuca gucuucucca                                                   20


<210>  6590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6590
uggucuuugc cugugguggu                                                   20


<210>  6591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6591
cagggugcag cuuuguccaa                                                   20


<210>  6592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6592
gggugcagcu uuguccaagu                                                   20


<210>  6593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6593
uugcacuugg acaaagcugc                                                   20


<210>  6594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6594
ccuggggcug ggcgcggugg                                                   20


<210>  6595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6595
uggggcuggg cgcgguggcu                                                   20


<210>  6596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6596
cgccuguaau ccuaacacua                                                   20


<210>  6597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6597
cauaguguua ggauuacagg                                                   20


<210>  6598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6598
ggcaaucugc cugucuuggc                                                   20


<210>  6599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6599
ggaguucgag accacccugg                                                   20


<210>  6600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6600
ugagcucagg caaucugccu                                                   20


<210>  6601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6601
aacuccugag cucaggcaau                                                   20


<210>  6602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6602
acuaaaauac aaaaaaaaua                                                   20


<210>  6603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6603
uggguagcug ggacuauaug                                                   20


<210>  6604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6604
gccuccuggg uagcugggac                                                   20


<210>  6605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6605
cggguucaag caauucuuau                                                   20


<210>  6606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6606
uacugcaaca ucugccuccc                                                   20


<210>  6607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6607
gcucauacug caacaucugc                                                   20


<210>  6608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6608
aucucggcuc auacugcaac                                                   20


<210>  6609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6609
agacugagug acacaacaag                                                   20


<210>  6610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6610
gucuggagua caguggcuca                                                   20


<210>  6611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6611
gccucaaaaa aaaaaaaaaa                                                   20


<210>  6612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6612
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  6613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6613
cccuagaacu ccuguuguuc                                                   20


<210>  6614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6614
cuagaacucc uguuguuccu                                                   20


<210>  6615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6615
uguuguuccu ggagcucuga                                                   20


<210>  6616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6616
aggaacaaca ggaguucuag                                                   20


<210>  6617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6617
gagaaacgug guuugaaaag                                                   20


<210>  6618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6618
gagcuccagg aacaacagga                                                   20


<210>  6619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6619
gguuggcccu uuucaaacca                                                   20


<210>  6620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6620
ugugaucaca aaagucaauc                                                   20


<210>  6621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6621
gcaaaccauc ugaaugcaac                                                   20


<210>  6622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6622
ggcagacacg aaagagaaug                                                   20


<210>  6623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6623
uucgugucug ccagagcaac                                                   20


<210>  6624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6624
cauucucuuu cgugucugcc                                                   20


<210>  6625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6625
agaacugugu cuguguuucu                                                   20


<210>  6626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6626
gcaaaguagc aaauccccac                                                   20


<210>  6627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6627
uuccugguua cccagugugg                                                   20


<210>  6628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6628
ucuccuuccu gguuacccag                                                   20


<210>  6629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6629
ccggaaggcc acacucaucu                                                   20


<210>  6630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6630
uccugagggg cgcuucaggc                                                   20


<210>  6631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6631
ggaagagcgg gucucaccgg                                                   20


<210>  6632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6632
ggugccugaa gcgccccuca                                                   20


<210>  6633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6633
cucaugacuc ccucagccaa                                                   20


<210>  6634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6634
ugacucccuc agccaaucuc                                                   20


<210>  6635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6635
cucagccaau cucagccuuc                                                   20


<210>  6636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6636
gccaaucuca gccuucugcc                                                   20


<210>  6637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6637
gccuucugcc aggccaacca                                                   20


<210>  6638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6638
ucaaccacca gagauuagaa                                                   20


<210>  6639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6639
accaccagag auuagaagaa                                                   20


<210>  6640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6640
ggugguugag gagucugguu                                                   20


<210>  6641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6641
aaaucaagug augaagcaug                                                   20


<210>  6642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6642
ggacaaaucg uuuaaaaaag                                                   20


<210>  6643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6643
ggaagaaugu guucacaaac                                                   20


<210>  6644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6644
agugucccug aggaccagga                                                   20


<210>  6645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6645
gggacacuug agaugggugu                                                   20


<210>  6646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6646
uccugcccag aggaagcuuc                                                   20


<210>  6647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6647
ugcccagagg aagcuuccag                                                   20


<210>  6648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6648
gggcaggagg agucaaagau                                                   20


<210>  6649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6649
aguggcuguu gggcuguggu                                                   20


<210>  6650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6650
gugagaaucg gccaccugcc                                                   20


<210>  6651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6651
cagagacccc acuucccuuu                                                   20


<210>  6652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6652
agcucucuuc acagacccug                                                   20


<210>  6653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6653
cuucacagac ccugaguggg                                                   20


<210>  6654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6654
ucacagaccc ugagugggga                                                   20


<210>  6655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6655
gggucuguga agagagcugg                                                   20


<210>  6656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6656
ccacucaggg ucugugaaga                                                   20


<210>  6657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6657
ccccacucag ggucugugaa                                                   20


<210>  6658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6658
gugauuuauu cauccugcuu                                                   20


<210>  6659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6659
uucauuuauu caugcacugc                                                   20


<210>  6660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6660
gcugaaagga aaauaaaaaa                                                   20


<210>  6661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6661
uauucccuuc uuuuuuauuu                                                   20


<210>  6662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6662
aauaaaugac caagaagcaa                                                   20


<210>  6663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6663
ugggcugugg ugcuuaaugg                                                   20


<210>  6664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6664
uuccauuaag caccacagcc                                                   20


<210>  6665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6665
gcaacugcgg caaaccaggg                                                   20


<210>  6666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6666
uuugugaagg uacuuugugu                                                   20


<210>  6667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6667
gucaucauua acagaaaaau                                                   20


<210>  6668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6668
acccucaguc aucauuaaca                                                   20


<210>  6669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6669
uucuccaccc ucagucauca                                                   20


<210>  6670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6670
uucucuuucu ccacccucag                                                   20


<210>  6671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6671
aguuucccuu cuauuuuuca                                                   20


<210>  6672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6672
ucuguugaac aguacagaag                                                   20


<210>  6673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6673
guugaacagu acagaagcag                                                   20


<210>  6674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6674
uuuucccaaa ugauccuuuc                                                   20


<210>  6675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6675
auguaaaauc cugcagguca                                                   20


<210>  6676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6676
uggcuugugg ggaaaaugac                                                   20


<210>  6677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6677
ugcauaucca gucuucugcu                                                   20


<210>  6678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6678
ccacacuuaa augcauaaca                                                   20


<210>  6679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6679
cgccuguaau uccaacacuu                                                   20


<210>  6680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6680
caaaguguug gaauuacagg                                                   20


<210>  6681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6681
gccucccaaa guguuggaau                                                   20


<210>  6682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6682
ggugaucugc cagccucagc                                                   20


<210>  6683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6683
ugaccucagg ugaucugcca                                                   20


<210>  6684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6684
aacuccugac cucaggugau                                                   20


<210>  6685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6685
gaauucaugc acuccucugc                                                   20


<210>  6686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6686
ucugcuccca ggaaaaaccu                                                   20


<210>  6687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6687
gcucccagga aaaaccuugg                                                   20


<210>  6688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6688
caggaaaaac cuugguuuac                                                   20


<210>  6689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6689
ccaguagcug ggauuacagg                                                   20


<210>  6690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6690
accuccccag uagcugggau                                                   20


<210>  6691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6691
ugccucaacc uccccaguag                                                   20


<210>  6692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6692
uggguucaag ugauucuccu                                                   20


<210>  6693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6693
gccuccuggg uucaagugau                                                   20


<210>  6694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6694
cugcaaccuc ugccuccugg                                                   20


<210>  6695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6695
gcucacugca accucugccu                                                   20


<210>  6696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6696
aauuagacca gcaguucuca                                                   20


<210>  6697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6697
accagaggca auuucacccu                                                   20


<210>  6698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6698
gguugagaac ugcuggucua                                                   20


<210>  6699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6699
ugcccaaaau gucaacagug                                                   20


<210>  6700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6700
gcacuguuga cauuuugggc                                                   20


<210>  6701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6701
gaauuagaug gugaguuucu                                                   20


<210>  6702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6702
ccaucuaauu cagagguucu                                                   20


<210>  6703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6703
gagcaaggau aucccauuuc                                                   20


<210>  6704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6704
gagaaacuca ccaucuaauu                                                   20


<210>  6705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6705
ggguucccgg ggacuaaagg                                                   20


<210>  6706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6706
ggcaagaagu aggugauuau                                                   20


<210>  6707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6707
cagggcaugc cccgucccag                                                   20


<210>  6708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6708
gggauugugg cccaggacuc                                                   20


<210>  6709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6709
gaacucagcu gaacaugcuu                                                   20


<210>  6710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6710
uggaauuggg cugcucugaa                                                   20


<210>  6711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6711
agcuucuagc acggugcuug                                                   20


<210>  6712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6712
uacaaacccc auauggauuc                                                   20


<210>  6713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6713
ggagggggug ggggucaaug                                                   20


<210>  6714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6714
ugagaaaggg aauccauaug                                                   20


<210>  6715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6715
cacagauguc agucuggcug                                                   20


<210>  6716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6716
gaaaggcugu ccacucccug                                                   20


<210>  6717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6717
cugucugaga auaaacagga                                                   20


<210>  6718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6718
gacagggagu ggacagccuu                                                   20


<210>  6719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6719
cacacacaca cacacacaca                                                   20


<210>  6720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6720
cacacacaca cacacacaca                                                   20


<210>  6721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6721
cucacacaca cacacacaca                                                   20


<210>  6722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6722
cucucacaca cacacacaca                                                   20


<210>  6723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6723
cucucucaca cacacacaca                                                   20


<210>  6724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6724
gaggucagca gaggcucagc                                                   20


<210>  6725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6725
gaguuaagga agucucucuc                                                   20


<210>  6726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6726
gcugaccucu gaguuaagga                                                   20


<210>  6727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6727
gcccugccca ccucagcccc                                                   20


<210>  6728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6728
gcccccacac accaaucccu                                                   20


<210>  6729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6729
gcccacagac uuucccagga                                                   20


<210>  6730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6730
guccgccucu uccuccccca                                                   20


<210>  6731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6731
uccuccccca cacccuucca                                                   20


<210>  6732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6732
cccacacccu uccagaugcu                                                   20


<210>  6733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6733
aauuucaaac uuccuggagu                                                   20


<210>  6734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6734
aggaaguuug aaauuggagu                                                   20


<210>  6735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6735
gaacuccagg aaguuugaaa                                                   20


<210>  6736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6736
gguuaugaag ggaugauaaa                                                   20


<210>  6737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6737
ggguugcaga ucuugguagu                                                   20


<210>  6738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6738
cuaaaaugug uuuacccuga                                                   20


<210>  6739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6739
cuagggaagg gauuuuuuuc                                                   20


<210>  6740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6740
ugcucccuag ggaagggauu                                                   20


<210>  6741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6741
ucuugcuccc uagggaaggg                                                   20


<210>  6742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6742
auauaccugc ccuccucuug                                                   20


<210>  6743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6743
caauauaccu gcccuccucu                                                   20


<210>  6744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6744
aagcugaccu uuaacccuca                                                   20


<210>  6745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6745
gccuuuucau cagaagauug                                                   20


<210>  6746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6746
gcuuaauaua uggucaaucu                                                   20


<210>  6747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6747
uccuuaucac gaaucagaug                                                   20


<210>  6748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6748
ucucccaggc uggcuucagu                                                   20


<210>  6749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6749
caggcuggcu ucaguccaga                                                   20


<210>  6750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6750
gcucagccag cacagauagu                                                   20


<210>  6751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6751
gccagcacag auaguguucc                                                   20


<210>  6752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6752
cauugccuuc aaaaugcagg                                                   20


<210>  6753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6753
gccaagauca cacagccagu                                                   20


<210>  6754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6754
cugaagguca auuucuucau                                                   20


<210>  6755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6755
gaaggucaau uucuucaugu                                                   20


<210>  6756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6756
ucugacauau aaauaggaau                                                   20


<210>  6757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6757
gacauauaaa uaggaauuca                                                   20


<210>  6758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6758
uaagaaugug uggcuucccc                                                   20


<210>  6759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6759
aaagucauga aacuuguugg                                                   20


<210>  6760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6760
gaagaucuug ccauauuuca                                                   20


<210>  6761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6761
cccagacuuc agugugaaau                                                   20


<210>  6762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6762
ugcuacuuca caaguucuaa                                                   20


<210>  6763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6763
cacacugaaa gggacccaaa                                                   20


<210>  6764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6764
uaaaaauuug ggucccuuuc                                                   20


<210>  6765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6765
acucuuaaaa auuugggucc                                                   20


<210>  6766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6766
augcauuaug gaauccuucc                                                   20


<210>  6767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6767
uccaugcauu auggaauccu                                                   20


<210>  6768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6768
ggcgaagauc aucaagcucu                                                   20


<210>  6769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6769
ggugaccaaa gccagaggug                                                   20


<210>  6770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6770
ggcuuugguc accagagcuu                                                   20


<210>  6771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6771
gggccgcaga aaugaaaggu                                                   20


<210>  6772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6772
cugaagccau uucaaaugca                                                   20


<210>  6773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6773
gaagccauuu caaaugcauc                                                   20


<210>  6774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6774
aaggugauga auuaaaccug                                                   20


<210>  6775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6775
ugaaaccuca aaggugauga                                                   20


<210>  6776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6776
ggucugcagc ccagggucgg                                                   20


<210>  6777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6777
ccuucaagga cacaggcacg                                                   20


<210>  6778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6778
cccuccccgc auccuccagu                                                   20


<210>  6779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6779
ccgcauccuc cagucaaucc                                                   20


<210>  6780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6780
agucaauccc caaggccuca                                                   20


<210>  6781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6781
gacagccaca ggaccccagg                                                   20


<210>  6782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6782
ugggguccug uggcugucug                                                   20


<210>  6783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6783
ugugccuggu caggccuguc                                                   20


<210>  6784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6784
agggcuucuc augccaccac                                                   20


<210>  6785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6785
ugccaccaca uuaaaaaaaa                                                   20


<210>  6786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6786
gacuugcuuu ucguaaacca                                                   20


<210>  6787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6787
cagacuugcu uuucguaaac                                                   20


<210>  6788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6788
gaggacaguc cccaagguac                                                   20


<210>  6789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6789
gaguugccuu cccacccaga                                                   20


<210>  6790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6790
gaacugcgaa cacugaccuu                                                   20


<210>  6791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6791
ccccugcucc cccauuucaa                                                   20


<210>  6792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6792
cccauuucaa aucugaaaug                                                   20


<210>  6793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6793
aaccaggacu gaacguuugc                                                   20


<210>  6794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6794
gaccccggca uuguaucauu                                                   20


<210>  6795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6795
uuauuucuaa acaccacuau                                                   20


<210>  6796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6796
aacccaaguc ucaaauguaa                                                   20


<210>  6797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6797
aauguaagag aauuuucacu                                                   20


<210>  6798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6798
uacauuugag acuuggguug                                                   20


<210>  6799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6799
ucgggcuugu uuucccuuca                                                   20


<210>  6800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6800
ggcuuguuuu cccuucacuc                                                   20


<210>  6801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6801
ccuuauucau uccauguccu                                                   20


<210>  6802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6802
uuauucauuc cauguccuug                                                   20


<210>  6803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6803
agagcccucc uuuuuaaaac                                                   20


<210>  6804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6804
agagaaggca cugauauaua                                                   20


<210>  6805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6805
uuuuuaaaac agcacaagaa                                                   20


<210>  6806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6806
cuuaaggugc cuucuugugc                                                   20


<210>  6807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6807
cucagacgca ggacaccucc                                                   20


<210>  6808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6808
gacgcaggac accuccucca                                                   20


<210>  6809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6809
uccagcugaa aaacuagauu                                                   20


<210>  6810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6810
agcugaaaaa cuagauucug                                                   20


<210>  6811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6811
caggccccag cauucuagcc                                                   20


<210>  6812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6812
uaaacucauu uaauuauguc                                                   20


<210>  6813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6813
uuuaauuaug uccagaguaa                                                   20


<210>  6814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6814
ggacauaauu aaaugaguuu                                                   20


<210>  6815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6815
uggggaucau ggguugcagg                                                   20


<210>  6816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6816
ugcaacccau gauccccaug                                                   20


<210>  6817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6817
uaccccgcca accuccugca                                                   20


<210>  6818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6818
uagcaugucu gggugaaucc                                                   20


<210>  6819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6819
cugucuccua gcaugucugg                                                   20


<210>  6820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6820
gggugaaaag ggauuaguga                                                   20


<210>  6821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6821
cuaaucccuu uucaccccga                                                   20


<210>  6822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6822
ucacuaaucc cuuuucaccc                                                   20


<210>  6823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6823
ggaaucucag acacccuuug                                                   20


<210>  6824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6824
gacacccuuu gaccaaaguu                                                   20


<210>  6825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6825
ugggaacuuu ggucaaaggg                                                   20


<210>  6826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6826
aaucuuagga agauuuuugu                                                   20


<210>  6827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6827
gucugcuuuu aaaaggaauc                                                   20


<210>  6828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6828
cuccccaauc aaacuccgca                                                   20


<210>  6829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6829
ccaaucaaac uccgcauggg                                                   20


<210>  6830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6830
gcauggggcu uucuuccucu                                                   20


<210>  6831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6831
accugucuga caggggaaag                                                   20


<210>  6832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6832
ucccaaauuc cccuucugag                                                   20


<210>  6833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6833
caaauucccc uucugagaag                                                   20


<210>  6834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6834
gaaggggaau uugggaggag                                                   20


<210>  6835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6835
uaccccuucu cagaagggga                                                   20


<210>  6836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6836
uuccuuuuug ucuacaagca                                                   20


<210>  6837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6837
acacuugaca ggcugugugg                                                   20


<210>  6838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6838
uggugacuga agccagccuc                                                   20


<210>  6839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6839
guuuuguccu cugugaugug                                                   20


<210>  6840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6840
gugaugugag gacuugagca                                                   20


<210>  6841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6841
caucacagag gacaaaacug                                                   20


<210>  6842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6842
aguccucaca ucacagagga                                                   20


<210>  6843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6843
ccuagccagg auacucuaca                                                   20


<210>  6844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6844
acaauugcac accccuggcu                                                   20


<210>  6845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6845
ccagggaacu uuaccuccug                                                   20


<210>  6846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6846
uggugagaag ggguuguggg                                                   20


<210>  6847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6847
ccaggaggua aaguucccug                                                   20


<210>  6848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6848
gcugccagca gaucuuggcc                                                   20


<210>  6849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6849
ccagcauggg ccauuaaucc                                                   20


<210>  6850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6850
cacuuaacaa uuaaguuuua                                                   20


<210>  6851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6851
cagauggcau gcucccuaau                                                   20


<210>  6852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6852
cuaauccuac agcuuacugc                                                   20


<210>  6853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6853
gauggugucu agccgugcag                                                   20


<210>  6854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6854
gucuuacccu gucccucgga                                                   20


<210>  6855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6855
ugcucaccuc ccaguuggcc                                                   20


<210>  6856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6856
ccucccaguu ggccccacac                                                   20


<210>  6857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6857
caguuggccc cacaccaugc                                                   20


<210>  6858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6858
gguccuggug aggccacuug                                                   20


<210>  6859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6859
ccaggaccug agugugcaug                                                   20


<210>  6860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6860
uaagggggca aaagaucccu                                                   20


<210>  6861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6861
ugggaaaggc ucaugguaag                                                   20


<210>  6862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6862
ugguaagaga acgcaccucc                                                   20


<210>  6863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6863
uaccaugagc cuuucccacg                                                   20


<210>  6864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6864
cuggaaacag augucuuggu                                                   20


<210>  6865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6865
cauaaaucau ucaggggagc                                                   20


<210>  6866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6866
ccugaaugau uuaugggagg                                                   20


<210>  6867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6867
aggccaaaag cacugccaca                                                   20


<210>  6868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6868
agcaacucca cacuucccca                                                   20


<210>  6869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6869
aguguggcag ugcuuuuggc                                                   20


<210>  6870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6870
acacuucccc acggcuuacu                                                   20


<210>  6871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6871
gccugugggc agaacccugg                                                   20


<210>  6872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6872
uccuuugcca auccuaccaa                                                   20


<210>  6873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6873
uuugccaauc cuaccaagug                                                   20


<210>  6874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6874
augcccaccc acguuggucu                                                   20


<210>  6875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6875
uuucucccac cuuucuugga                                                   20


<210>  6876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6876
caccuuucuu ggaucaucuc                                                   20


<210>  6877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6877
cacagaguug ggggcuccag                                                   20


<210>  6878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6878
gugugagaug auccaagaaa                                                   20


<210>  6879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6879
aggucccauu uuuuaucuuc                                                   20


<210>  6880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6880
gguuugggca uucucucuga                                                   20


<210>  6881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6881
cugacucuaa cuugcguugu                                                   20


<210>  6882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6882
gacucuaacu ugcguuguuu                                                   20


<210>  6883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6883
aacuugcguu guuuguuuca                                                   20


<210>  6884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6884
cuccacauug uauuuucugu                                                   20


<210>  6885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6885
ccacauugua uuuucuguag                                                   20


<210>  6886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6886
acauuguauu uucuguaguc                                                   20


<210>  6887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6887
uucaauugcg cacuuacagu                                                   20


<210>  6888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6888
caccuguuug ccaucaaucc                                                   20


<210>  6889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6889
ccuguuugcc aucaaucccc                                                   20


<210>  6890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6890
gaugugucuu cuaucacuau                                                   20


<210>  6891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6891
agacaaggca aaacaauagu                                                   20


<210>  6892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6892
aggaauaugc uaugugaaag                                                   20


<210>  6893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6893
acacaucaua ugguugcaug                                                   20


<210>  6894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6894
uuuuagagcu gaguaauauu                                                   20


<210>  6895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6895
aaaaagagcu gaaguacuga                                                   20


<210>  6896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6896
gcucuaaaaa gagcugaagu                                                   20


<210>  6897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6897
uuuccccugg gaauauagcu                                                   20


<210>  6898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6898
gcaauuuauc ugcuagcuau                                                   20


<210>  6899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6899
aaugaucaaa auuaaaaaga                                                   20


<210>  6900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6900
uugugguuuu aauuugcauu                                                   20


<210>  6901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6901
uuuucauugu guugcauuga                                                   20


<210>  6902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6902
aaagucaaua guaagaaauc                                                   20


<210>  6903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6903
caaaagucaa uaguaagaaa                                                   20


<210>  6904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6904
cagucugucu ugucuuuuua                                                   20


<210>  6905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6905
uuugaugaaa agauugcccu                                                   20


<210>  6906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6906
ggacuuuguu cuauugaucc                                                   20


<210>  6907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6907
aaauguguuu uucuuuuuca                                                   20


<210>  6908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6908
cccuguuaug uuuuaagcuc                                                   20


<210>  6909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6909
cuguuauguu uuaagcuccu                                                   20


<210>  6910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6910
uggaggacaa ggaaccuauc                                                   20


<210>  6911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6911
aggagcuuaa aacauaacag                                                   20


<210>  6912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6912
ggaaccaugg ggaaaugcaa                                                   20


<210>  6913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6913
ggcaaugcgg cugugauugg                                                   20


<210>  6914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6914
ccgcccccaa ucacagccgc                                                   20


<210>  6915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6915
cuuggcuuuc acccuccccg                                                   20


<210>  6916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6916
cgcuuggcuu ucacccuccc                                                   20


<210>  6917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6917
cucgcuuggc uuucacccuc                                                   20


<210>  6918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6918
acaccauucc uugccuucug                                                   20


<210>  6919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6919
cgucugccug ugacucuaca                                                   20


<210>  6920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6920
uggcuggugu cauguauucu                                                   20


<210>  6921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6921
ggagaggcca guuuucuucu                                                   20


<210>  6922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6922
cgagucacca cuuccuugug                                                   20


<210>  6923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6923
cccgagucac cacuuccuug                                                   20


<210>  6924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6924
uagccaaggu cacuguuuca                                                   20


<210>  6925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6925
aguucugggg aucuugcaac                                                   20


<210>  6926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6926
aggaacccua gcuuguccua                                                   20


<210>  6927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6927
uucuagaagg aagcuaaagu                                                   20


<210>  6928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6928
gagaucaucu aguccacauu                                                   20


<210>  6929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6929
gagaccuuuc uagcucuuuc                                                   20


<210>  6930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6930
ucuauaaaau guggacuaga                                                   20


<210>  6931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6931
gucuuuccag uucuuguuuu                                                   20


<210>  6932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6932
gugaccucag ucuuuccagu                                                   20


<210>  6933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6933
aggcuguuga ccuuuuggcu                                                   20


<210>  6934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6934
ccccacuuuu uuuuuuuuuu                                                   20


<210>  6935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6935
ccugucuguc accagagcca                                                   20


<210>  6936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6936
ugucugucac cagagccauu                                                   20


<210>  6937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6937
ggugacagac aggagaggac                                                   20


<210>  6938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6938
aguucuguga cguaaauggc                                                   20


<210>  6939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6939
uagaagucaa ucaguuggcu                                                   20


<210>  6940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6940
uccuuuccug ugcaucuauc                                                   20


<210>  6941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6941
uuuccugugc aucuaucaac                                                   20


<210>  6942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6942
ucaaaauccc cucuauaacc                                                   20


<210>  6943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6943
auaaccagac ucccuuuccc                                                   20


<210>  6944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6944
cuuucccugc cauuugcuuc                                                   20


<210>  6945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6945
ccaaaauacc ugggaaggcc                                                   20


<210>  6946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6946
agaaacaaac uuuuucugaa                                                   20


<210>  6947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6947
cugccagaag caggaauuac                                                   20


<210>  6948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6948
uuuguaauuc cugcuucugg                                                   20


<210>  6949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6949
gguuccugga agacucaaaa                                                   20


<210>  6950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6950
aaacucagug agccuggaac                                                   20


<210>  6951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6951
gugagccugg aacugacccu                                                   20


<210>  6952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6952
cugaguuuug agucuuccag                                                   20


<210>  6953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6953
gcuuaucucu ccugcuuuga                                                   20


<210>  6954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6954
ccugcuuuga gcaauuuaau                                                   20


<210>  6955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6955
ugcuuugagc aauuuaauua                                                   20


<210>  6956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6956
aagcaggaga gauaagcaga                                                   20


<210>  6957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6957
cucuagccac cucccccacc                                                   20


<210>  6958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6958
agccaccucc cccacccacg                                                   20


<210>  6959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6959
cccacccacg uccuaaucuu                                                   20


<210>  6960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6960
ccccuccaag gagaaccaua                                                   20


<210>  6961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6961
aaggagaacc auacugucuu                                                   20


<210>  6962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6962
uuggaggggg gaggugggaa                                                   20


<210>  6963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6963
aagacaagac aguaugguuc                                                   20


<210>  6964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6964
auuugcaugg aaauguggca                                                   20


<210>  6965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6965
ggacacucaa uuugcaugga                                                   20


<210>  6966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6966
auggcugagu ugcuggagua                                                   20


<210>  6967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6967
gccauggaga aaguccgggc                                                   20


<210>  6968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6968
agcaacucag ccauggagaa                                                   20


<210>  6969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6969
ucugugaaaa cuauggaugc                                                   20


<210>  6970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6970
auuaccuaca aauggcaucc                                                   20


<210>  6971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6971
gcauauuuuu cuaauuauca                                                   20


<210>  6972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6972
gucuccaaaa uaugccccca                                                   20


<210>  6973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6973
aaaauaugcc cccauccuag                                                   20


<210>  6974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6974
aggggccccc agccacuagc                                                   20


<210>  6975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6975
auggcuagug gcugggggcc                                                   20


<210>  6976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6976
guuccucaau ggcuaguggc                                                   20


<210>  6977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6977
auccaacaac ccacaaggaa                                                   20


<210>  6978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6978
gggauguuuu cuccauaaga                                                   20


<210>  6979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6979
auaagauaau cagauuuuaa                                                   20


<210>  6980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6980
cagaagacaa ugggugggcg                                                   20


<210>  6981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6981
ccaucgccca cccauugucu                                                   20


<210>  6982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6982
cuucucacca ucgcccaccc                                                   20


<210>  6983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6983
acucacuucu caccaucgcc                                                   20


<210>  6984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6984
aaaagauagc uacuaacaua                                                   20


<210>  6985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6985
cucacaauuu gucuacaagg                                                   20


<210>  6986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6986
caauuugucu acaaggaaau                                                   20


<210>  6987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6987
aaagaaugca accauuuguc                                                   20


<210>  6988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6988
ucuguaccua ugaccuggaa                                                   20


<210>  6989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6989
cagcaggaag gggguuucca                                                   20


<210>  6990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6990
uccuuuuuua cggcugcaua                                                   20


<210>  6991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6991
aaaauuggua guaguuguua                                                   20


<210>  6992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6992
ccacaacccu ggggaaaaaa                                                   20


<210>  6993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6993
ggauuuuuuu ccccaggguu                                                   20


<210>  6994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6994
cuggauuuuu uuccccaggg                                                   20


<210>  6995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6995
gacaugugcu aacugccuac                                                   20


<210>  6996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6996
gcucugacau gugcuaacug                                                   20


<210>  6997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6997
ucucucuugu auuugcuuau                                                   20


<210>  6998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6998
acaauggaau auuaugcagc                                                   20


<210>  6999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  6999
aauuauuuuc uuaggcuaga                                                   20


<210>  7000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7000
agccuaagaa aauaauugga                                                   20


<210>  7001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7001
agugcucuag ccuaagaaaa                                                   20


<210>  7002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7002
ucuagugcuc uagccuaaga                                                   20


<210>  7003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7003
cgaugccagu ugccaaauug                                                   20


<210>  7004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7004
uugggaauau gaauugguac                                                   20


<210>  7005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7005
cacuuuaaaa cacccuuucc                                                   20


<210>  7006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7006
uugaguuccg cacaaaggcc                                                   20


<210>  7007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7007
aggaguuguu ccuuuaaaca                                                   20


<210>  7008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7008
gaaccccugu gaaccauggg                                                   20


<210>  7009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7009
gcccaugguu cacagggguu                                                   20


<210>  7010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7010
ugguuguagg aggagauuca                                                   20


<210>  7011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7011
uacaaccaug aguaaaauga                                                   20


<210>  7012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7012
uccuacaacc augaguaaaa                                                   20


<210>  7013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7013
agaaaggacc auacacguuu                                                   20


<210>  7014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7014
aaguggauaa ggauauuuuu                                                   20


<210>  7015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7015
uuguguaugu guauagaaau                                                   20


<210>  7016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7016
uucucuuugu guauguguau                                                   20


<210>  7017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7017
cuccuucucu uuguguaugu                                                   20


<210>  7018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7018
gcucccuccu ucucuuugug                                                   20


<210>  7019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7019
uucugggugg cuaaauauuu                                                   20


<210>  7020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7020
ucuuucuggg uggcuaaaua                                                   20


<210>  7021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7021
agaugguacc uaaggccaaa                                                   20


<210>  7022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7022
accccaauuu guuaugcauu                                                   20


<210>  7023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7023
uccaauucac aaaggaaaau                                                   20


<210>  7024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7024
cucuuccaau ucacaaagga                                                   20


<210>  7025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7025
cccucuucca auucacaaag                                                   20


<210>  7026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7026
cucccucuuc caauucacaa                                                   20


<210>  7027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7027
guaguuacuu ggauuuucac                                                   20


<210>  7028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7028
aaaaaccaua ccacgcaggc                                                   20


<210>  7029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7029
gacugaugca gggcauuuca                                                   20


<210>  7030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7030
cugacugaug cagggcauuu                                                   20


<210>  7031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7031
aaggccuaac acaauaaacu                                                   20


<210>  7032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7032
cccagccccu augccugugu                                                   20


<210>  7033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7033
ggcauaccag cauggcugcc                                                   20


<210>  7034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7034
agagauaaac auggacaucc                                                   20


<210>  7035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7035
ugaggcccau uaauuugguu                                                   20


<210>  7036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7036
uaggguuuug gauggauguc                                                   20


<210>  7037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7037
gcuuugccac ugguggugac                                                   20


<210>  7038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7038
ccgggggugg cuguuguugc                                                   20


<210>  7039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7039
aagugguauu guguggcuuc                                                   20


<210>  7040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7040
accccacaac uuccaaccuc                                                   20


<210>  7041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7041
ccuguccaac ugcagagcac                                                   20


<210>  7042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7042
uguccaacug cagagcacua                                                   20


<210>  7043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7043
uuaaauaaag uuuauuggca                                                   20


<210>  7044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7044
gaaguugcca auaaacuuua                                                   20


<210>  7045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7045
gcuucucaga aguugccaau                                                   20


<210>  7046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7046
gaaaaccaac cugacaccga                                                   20


<210>  7047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7047
gugucagguu gguuuucaga                                                   20


<210>  7048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7048
ucaaccaaug aaacaccugc                                                   20


<210>  7049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7049
uuucugugcg ugaucaaaac                                                   20


<210>  7050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7050
ugggaacaca gggcuuuuaa                                                   20


<210>  7051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7051
acuuuuagga cuccucucau                                                   20


<210>  7052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7052
ucucauuauu auuucaucaa                                                   20


<210>  7053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7053
cauuauuauu ucaucaauua                                                   20


<210>  7054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7054
uuauuauuuc aucaauuauu                                                   20


<210>  7055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7055
uugacagcaa uuuccacaug                                                   20


<210>  7056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7056
ccccucccag uucuccuucu                                                   20


<210>  7057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7057
caguucuccu ucuggacuua                                                   20


<210>  7058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7058
uucuggacuu agagcuaguc                                                   20


<210>  7059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7059
aaguccagaa ggagaacugg                                                   20


<210>  7060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7060
cacguucauc ugccuuaaua                                                   20


<210>  7061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7061
ucacuauuug aggguugaaa                                                   20


<210>  7062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7062
aauagugaag agggugguuu                                                   20


<210>  7063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7063
agguaguuau aauugaaccu                                                   20


<210>  7064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7064
aagcagguga ccuugcaaag                                                   20


<210>  7065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7065
aauuuaccuc ugcaucucac                                                   20


<210>  7066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7066
gcaucucacu gcccccagac                                                   20


<210>  7067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7067
cugcccccag acacaaguuc                                                   20


<210>  7068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7068
ucucuauuca ugguuccugc                                                   20


<210>  7069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7069
auucaugguu ccugcaaauc                                                   20


<210>  7070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7070
gagacccagc uugagauccu                                                   20


<210>  7071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7071
gagcacagaa aagauuugca                                                   20


<210>  7072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7072
agcugggucu cagagcacag                                                   20


<210>  7073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7073
caagacaugg ugccaagccu                                                   20


<210>  7074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7074
agacauggug ccaagccucu                                                   20


<210>  7075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7075
ccagcugaca uauucucccu                                                   20


<210>  7076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7076
agcugacaua uucucccuuc                                                   20


<210>  7077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7077
cuucccugaa uucauauagc                                                   20


<210>  7078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7078
uaaauuagca cuuaauuaca                                                   20


<210>  7079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7079
aaggggaaga aucagacaau                                                   20


<210>  7080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7080
gugugcucua aggggaagaa                                                   20


<210>  7081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7081
acauggggca cucugugugc                                                   20


<210>  7082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7082
ucaaacaugc ugccuccaca                                                   20


<210>  7083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7083
auuaauauuu cuuaaauuaa                                                   20


<210>  7084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7084
uauuaauuaa uuaauuuaag                                                   20


<210>  7085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7085
aaaauccaug cucuuauuaa                                                   20


<210>  7086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7086
auaaagguca ucuagcuagu                                                   20


<210>  7087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7087
aaugucuuua ucuggaaaau                                                   20


<210>  7088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7088
aagccaugua gcauuauugc                                                   20


<210>  7089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7089
caguugcuca aguggagagc                                                   20


<210>  7090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7090
aguggagagc auguucuuua                                                   20


<210>  7091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7091
acuugagcaa cugugaggug                                                   20


<210>  7092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7092
ccacuugagc aacugugagg                                                   20


<210>  7093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7093
gugggcacuu ggcaggggua                                                   20


<210>  7094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7094
ggaauacaaa cugguuuaga                                                   20


<210>  7095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7095
acauuuccca aauuguauua                                                   20


<210>  7096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7096
cagcuguaau cccagcacuu                                                   20


<210>  7097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7097
caaagugcug ggauuacagc                                                   20


<210>  7098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7098
gccucccaaa gugcugggau                                                   20


<210>  7099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7099
gaugauccgc ccgccucugc                                                   20


<210>  7100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7100
acuaaaaaau acaaaaauua                                                   20


<210>  7101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7101
ggaggcugag acaggagaau                                                   20


<210>  7102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7102
cgaguagcua ugauuuuugg                                                   20


<210>  7103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7103
gccucccgag uagcuaugau                                                   20


<210>  7104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7104
ugucucagcc ucccgaguag                                                   20


<210>  7105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7105
cagguucaag cgauucuccu                                                   20


<210>  7106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7106
gccucccagg uucaagcgau                                                   20


<210>  7107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7107
cugcaaccuc ugccucccag                                                   20


<210>  7108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7108
gcucacugca accucugccu                                                   20


<210>  7109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7109
aauuuaggca acagaguaag                                                   20


<210>  7110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7110
guugccuaaa uuggagugca                                                   20


<210>  7111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7111
gucucaaaaa uaaaauaaac                                                   20


<210>  7112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7112
aaaauaaaau aaacuaaaau                                                   20


<210>  7113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7113
auuuguguuu guaaacugaa                                                   20


<210>  7114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7114
gcauucuaag cuauauuuca                                                   20


<210>  7115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7115
gccucguaaa uacucccagc                                                   20


<210>  7116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7116
uaaauacucc cagccuaaug                                                   20


<210>  7117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7117
cagccuaaug acucaaugcc                                                   20


<210>  7118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7118
augcccccaa acagccccug                                                   20


<210>  7119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7119
ugaccaaguu gggacccugc                                                   20


<210>  7120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7120
uuccccugac uggccugcac                                                   20


<210>  7121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7121
uucucucuca ccacagauug                                                   20


<210>  7122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7122
cucaccacag auugcucaug                                                   20


<210>  7123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7123
caccacagau ugcucauggc                                                   20


<210>  7124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7124
ccacagauug cucauggcag                                                   20


<210>  7125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7125
uggcagguga cuccucggug                                                   20


<210>  7126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7126
ucggugauuc agggaugccu                                                   20


<210>  7127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7127
gugauucagg gaugccuccu                                                   20


<210>  7128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7128
ugugccucug ccugguggcu                                                   20


<210>  7129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7129
gccugguggc uucguaccug                                                   20


<210>  7130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7130
ggguggccag guacgaagcc                                                   20


<210>  7131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7131
cagacgcccc uccuggguuc                                                   20


<210>  7132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7132
uggguucucu uccagugaga                                                   20


<210>  7133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7133
uccagugaga guccuguaga                                                   20


<210>  7134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7134
cuggaagaga acccaggagg                                                   20


<210>  7135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7135
cacuggaaga gaacccagga                                                   20


<210>  7136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7136
uagauucuac aggacucuca                                                   20


<210>  7137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7137
ugcuacagau gagaaaacua                                                   20


<210>  7138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7138
ucuguagcag gagccaacca                                                   20


<210>  7139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7139
gggucuuagu uuucucaucu                                                   20


<210>  7140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7140
ucucuggguc uuaguuuucu                                                   20


<210>  7141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7141
uucaguucac guucuucucu                                                   20


<210>  7142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7142
aauccuugcu ccuucaguuc                                                   20


<210>  7143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7143
cgggcucuaa uccuugcucc                                                   20


<210>  7144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7144
gcagcccccu cccugagaca                                                   20


<210>  7145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7145
cugagacacu ccugucagcu                                                   20


<210>  7146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7146
gggagggggc ugcugagguu                                                   20


<210>  7147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7147
ugucagcuca cauggggagu                                                   20


<210>  7148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7148
cauggggagu aggaggaguu                                                   20


<210>  7149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7149
ccaugugagc ugacaggagu                                                   20


<210>  7150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7150
uacuccccau gugagcugac                                                   20


<210>  7151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7151
uccuacuccc caugugagcu                                                   20


<210>  7152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7152
cugccagcgc uccugccagc                                                   20


<210>  7153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7153
ugccagcucg ucucaucuca                                                   20


<210>  7154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7154
ucucaucuca gcucacuccc                                                   20


<210>  7155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7155
ucucagcuca cuccccgacc                                                   20


<210>  7156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7156
gcucacuccc cgaccuucca                                                   20


<210>  7157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7157
cuccccgacc uuccauccuc                                                   20


<210>  7158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7158
ccgaccuucc auccucucaa                                                   20


<210>  7159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7159
caaagucaga guccuuucuu                                                   20


<210>  7160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7160
aagucagagu ccuuucuuca                                                   20


<210>  7161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7161
gacuuugaga ggauggaagg                                                   20


<210>  7162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7162
ccuugauggu uccugaagaa                                                   20


<210>  7163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7163
gauagauuua gcacaucuca                                                   20


<210>  7164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7164
ucagauagau uuagcacauc                                                   20


<210>  7165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7165
ccucagauag auuuagcaca                                                   20


<210>  7166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7166
ucuccucaga uagauuuagc                                                   20


<210>  7167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7167
cagauaaucu gagaauaaua                                                   20


<210>  7168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7168
gauuaucugg gaggggucuu                                                   20


<210>  7169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7169
uuccuucagu aggccguugu                                                   20


<210>  7170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7170
aaagagggca ucugaauucg                                                   20


<210>  7171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7171
uuugagguug cuguucuggu                                                   20


<210>  7172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7172
gaauucagau gcccucuuuu                                                   20


<210>  7173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7173
ccugccuucc ccuccgaauu                                                   20


<210>  7174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7174
ggaguggccc agagacucca                                                   20


<210>  7175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7175
ugaggcuggc cagcuccccu                                                   20


<210>  7176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7176
gggccacucc ugaggcuggc                                                   20


<210>  7177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7177
auucaucagu gccaucagcu                                                   20


<210>  7178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7178
cuagccugac ccagcacuca                                                   20


<210>  7179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7179
cacccugccc uuccaagaaa                                                   20


<210>  7180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7180
ccccuccaug gaaggguuag                                                   20


<210>  7181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7181
auggaagggu uaggaccagc                                                   20


<210>  7182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7182
agccugagca cugcaagagc                                                   20


<210>  7183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7183
ggcuagagcu gguccuaacc                                                   20


<210>  7184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7184
ugcagugcuc aggcuagagc                                                   20


<210>  7185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7185
auucccacac ucaccccaca                                                   20


<210>  7186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7186
ccccacaaca uccaacacac                                                   20


<210>  7187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7187
ugccuagccc ucagcaugug                                                   20


<210>  7188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7188
gcaugugucu aaacccaggc                                                   20


<210>  7189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7189
uucugcagac uucccuuggg                                                   20


<210>  7190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7190
ucuaaccggu ucuguggccu                                                   20


<210>  7191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7191
aacaaacccc cggacugcuc                                                   20


<210>  7192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7192
cagccucagu uuacuucucu                                                   20


<210>  7193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7193
gccucaguuu acuucucuga                                                   20


<210>  7194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7194
guuuacuucu cugagaaauu                                                   20


<210>  7195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7195
gagaaauuag ggcaauagca                                                   20


<210>  7196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7196
gagaaguaaa cugaggcuga                                                   20


<210>  7197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7197
augccaccca gguauugcua                                                   20


<210>  7198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7198
uuuugucucu augccaccca                                                   20


<210>  7199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7199
ucaaacuuaa aaguauuugu                                                   20


<210>  7200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7200
uugcauuacu aguaauaaua                                                   20


<210>  7201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7201
acccagauau uuacucagaa                                                   20


<210>  7202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7202
gaauuuucag agaauucccc                                                   20


<210>  7203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7203
gaaaauucug aguaaauauc                                                   20


<210>  7204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7204
uucuuccaag gugcuuggua                                                   20


<210>  7205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7205
ugcugcucaa auucccuugu                                                   20


<210>  7206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7206
aauucccuug uaguuaaucc                                                   20


<210>  7207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7207
caggacucag gaaacaaaac                                                   20


<210>  7208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7208
ggacucagga aacaaaaccg                                                   20


<210>  7209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7209
ggaaacaaaa ccguuuggua                                                   20


<210>  7210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7210
gucaccagca aauauaugcu                                                   20


<210>  7211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7211
gugcuaccug agagcaaauc                                                   20


<210>  7212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7212
gguagcacug agcauauauu                                                   20


<210>  7213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7213
cagguagcac ugagcauaua                                                   20


<210>  7214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7214
ucugcacugg uuucagaaug                                                   20


<210>  7215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7215
gcacugguuu cagaauguaa                                                   20


<210>  7216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7216
aaaguaaagg gacuucagaa                                                   20


<210>  7217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7217
agaacuggcc ucaaaaguaa                                                   20


<210>  7218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7218
uacaguuugg gaggcugagg                                                   20


<210>  7219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7219
caaacuguag gaguacaggu                                                   20


<210>  7220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7220
gccucccaaa cuguaggagu                                                   20


<210>  7221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7221
ugccucagcc ucccaaacug                                                   20


<210>  7222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7222
agggauccuc augccucagc                                                   20


<210>  7223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7223
ugggcucaag ggauccucau                                                   20


<210>  7224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7224
aacucuuggg cucaagggau                                                   20


<210>  7225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7225
guauguugcc caggcuggcc                                                   20


<210>  7226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7226
acaaaaaauu agccgggugu                                                   20


<210>  7227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7227
ccaguagcug gggauagcca                                                   20


<210>  7228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7228
gccuccccag uagcugggga                                                   20


<210>  7229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7229
caccucagcc uccccaguag                                                   20


<210>  7230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7230
agcaauccuc ccaccucagc                                                   20


<210>  7231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7231
ugggcucaag caauccuccc                                                   20


<210>  7232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7232
uccuccuggg cucaagcaau                                                   20


<210>  7233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7233
cugcagccuc auccuccugg                                                   20


<210>  7234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7234
gucacccagg cuggaaugca                                                   20


<210>  7235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7235
guuuuauuuu auuuuuaaga                                                   20


<210>  7236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7236
uggcaacaaa caaaacaugu                                                   20


<210>  7237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7237
gcuuuaucuc aguguucaca                                                   20


<210>  7238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7238
guguucacac cuugcauucc                                                   20


<210>  7239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7239
guucgguccc gaagguuaaa                                                   20


<210>  7240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7240
acuaucuugu ugcuuaaagg                                                   20


<210>  7241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7241
uuuuucccuu uaagcaacaa                                                   20


<210>  7242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7242
cuuuuuuccc uuuaagcaac                                                   20


<210>  7243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7243
ucucuuuuuu cccuuuaagc                                                   20


<210>  7244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7244
gccagccuua gucccuuuuu                                                   20


<210>  7245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7245
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  7246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7246
gucucaaaaa aaaaaaaaaa                                                   20


<210>  7247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7247
cucugucauc caagcuggag                                                   20


<210>  7248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7248
gucauccaag cuggagcaua                                                   20


<210>  7249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7249
agcuuggaug acagagcgag                                                   20


<210>  7250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7250
cugcagccuc aaagucuuca                                                   20


<210>  7251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7251
aagucuucag cucaagcaag                                                   20


<210>  7252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7252
agcaaguagc uaagauuaca                                                   20


<210>  7253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7253
aaguccaagu uugaaagcca                                                   20


<210>  7254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7254
caguaaagag cugggcccca                                                   20


<210>  7255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7255
uuacugugag uuugugacau                                                   20


<210>  7256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7256
cuaccuuggg gcccagcucu                                                   20


<210>  7257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7257
caucauuuua aaagccccua                                                   20


<210>  7258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7258
cuuuugaaua auuuuuaagc                                                   20


<210>  7259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7259
aauuauauuc ucacuuuuga                                                   20


<210>  7260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7260
uccucaaaag aaaccuucca                                                   20


<210>  7261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7261
ucaaaagaaa ccuuccacua                                                   20


<210>  7262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7262
aaagaaaccu uccacuaaag                                                   20


<210>  7263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7263
aagggcgcag uucaucaaga                                                   20


<210>  7264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7264
uaucaacccc cggccuuaaa                                                   20


<210>  7265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7265
ggggauaaaa cacauaaaua                                                   20


<210>  7266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7266
cacccuaggg auaugauccu                                                   20


<210>  7267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7267
agggcugcug ccaugcagua                                                   20


<210>  7268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7268
ucucuggcug auacugggac                                                   20


<210>  7269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7269
ggcugauacu gggacaguuu                                                   20


<210>  7270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7270
ugcagggaaa cugucccagu                                                   20


<210>  7271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7271
ggccccagag aaugccucuc                                                   20


<210>  7272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7272
ggggccugag acuccugcag                                                   20


<210>  7273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7273
cuucccagca cuaagguaug                                                   20


<210>  7274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7274
ucccagcacu aagguaugcg                                                   20


<210>  7275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7275
gcccaagggg ucgcauaccu                                                   20


<210>  7276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7276
cccagagaca ccuuguuccu                                                   20


<210>  7277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7277
cagagacacc uuguuccuuu                                                   20


<210>  7278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7278
gggagagguc cagguggugc                                                   20


<210>  7279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7279
cuucuuccuu ugccuccuuu                                                   20


<210>  7280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7280
ucuuccuuug ccuccuuuuu                                                   20


<210>  7281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7281
uuuuuugcuu uuguuuguuc                                                   20


<210>  7282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7282
agaaaaaaaa aaaaaaaaaa                                                   20


<210>  7283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7283
gucucaagaa aaaaaaaaaa                                                   20


<210>  7284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7284
cucuugucac ccaggcugga                                                   20


<210>  7285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7285
ugucacccag gcuggacugc                                                   20


<210>  7286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7286
gcucacugca accuccgccu                                                   20


<210>  7287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7287
cugcaaccuc cgccucccag                                                   20


<210>  7288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7288
gccucccagg uucaagcgau                                                   20


<210>  7289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7289
cagguucaag cgauucucgu                                                   20


<210>  7290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7290
ugccucagcc ucccaaguag                                                   20


<210>  7291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7291
gccucccaag uagcugggau                                                   20


<210>  7292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7292
caaguagcug ggauuacagg                                                   20


<210>  7293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7293
acugaaaaua ccaaaauuaa                                                   20


<210>  7294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7294
uguccucaag ugaccuuggc                                                   20


<210>  7295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7295
agugaccuug gccucccaaa                                                   20


<210>  7296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7296
caaagugcug agauuacagg                                                   20


<210>  7297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7297
gcacuuuggg aggccaaggu                                                   20


<210>  7298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7298
ugccuguaau cucagcacuu                                                   20


<210>  7299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7299
caaaugauua aaaugguaaa                                                   20


<210>  7300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7300
ucccaccguc uaccuccaac                                                   20


<210>  7301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7301
aacacuuuuu caucaucccc                                                   20


<210>  7302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7302
ccuuccccau ccccucauua                                                   20


<210>  7303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7303
uuaaucccuu aguaaucucu                                                   20


<210>  7304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7304
auuccauuuu cugucucuau                                                   20


<210>  7305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7305
augaauuuac ccaguauagg                                                   20


<210>  7306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7306
uggaagugga aucauauaau                                                   20


<210>  7307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7307
uuuuauaucu ggcauaucuc                                                   20


<210>  7308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7308
uuuagcacaa uguaugugag                                                   20


<210>  7309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7309
cauacauugu gcuaaaugag                                                   20


<210>  7310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7310
cauuuuguuu auccauucau                                                   20


<210>  7311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7311
ucuuuucuuu uuuuuuuuuu                                                   20


<210>  7312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7312
ggaaaaaaaa aaaaaaaaaa                                                   20


<210>  7313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7313
gucacccagg cuggagugca                                                   20


<210>  7314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7314
agccugggug acagagggaa                                                   20


<210>  7315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7315
gcucacugca accuccgccu                                                   20


<210>  7316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7316
cugcaaccuc cgccucccgg                                                   20


<210>  7317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7317
gccucccggg cuuaagugau                                                   20


<210>  7318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7318
cgggcuuaag ugauucucgu                                                   20


<210>  7319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7319
ugccucagcc uccugaguag                                                   20


<210>  7320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7320
gccuccugag uagcuggaau                                                   20


<210>  7321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7321
ugaguagcug gaauuacagg                                                   20


<210>  7322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7322
ggaggcugag gcacgagaau                                                   20


<210>  7323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7323
acuaaaaaua uaaaaauuag                                                   20


<210>  7324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7324
uggugucaag ugaucugccc                                                   20


<210>  7325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7325
gccuccugaa gugcuuggga                                                   20


<210>  7326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7326
ugaagugcuu gggauuacag                                                   20


<210>  7327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7327
ugccuguaau cccaagcacu                                                   20


<210>  7328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7328
uucaucuuuu uauggaugcu                                                   20


<210>  7329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7329
cguucauagc aguauuaguc                                                   20


<210>  7330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7330
cagguguaua gccaaaagaa                                                   20


<210>  7331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7331
aaaaguugca cacuuaccau                                                   20


<210>  7332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7332
aucuucucua cauucuaacu                                                   20


<210>  7333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7333
acauucuaac uaacacuugu                                                   20


<210>  7334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7334
aucaaaaaaa gcaggcaaac                                                   20


<210>  7335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7335
accuccauca aaaaaagcag                                                   20


<210>  7336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7336
gugaauuggc ugugacaaua                                                   20


<210>  7337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7337
uuuagcuauu gucacagcca                                                   20


<210>  7338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7338
uacugaagag auguuuccua                                                   20


<210>  7339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7339
ucaguaugag guagcagccu                                                   20


<210>  7340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7340
ggugacaaac uuaggaaaca                                                   20


<210>  7341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7341
ccggugacaa acuuaggaaa                                                   20


<210>  7342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7342
aagacaauaa guugguucgg                                                   20


<210>  7343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7343
gagaaaaaaa cagucuacag                                                   20


<210>  7344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7344
gagaaguuca agucuucugc                                                   20


<210>  7345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7345
cacacuacug aaagcucuac                                                   20


<210>  7346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7346
acccugggga ccuggcuuga                                                   20


<210>  7347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7347
ggagagcucc cagcugcucu                                                   20


<210>  7348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7348
ugagauaaca cagcuaguua                                                   20


<210>  7349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7349
ccugagauaa cacagcuagu                                                   20


<210>  7350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7350
cagcugcucu gagucucagu                                                   20


<210>  7351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7351
gagucucagu cucucaauca                                                   20


<210>  7352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7352
gagcagcugg gagcucuccu                                                   20


<210>  7353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7353
gucucucaau cagugaaaug                                                   20


<210>  7354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7354
caaucaguga aauggaggca                                                   20


<210>  7355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7355
aucagugaaa uggaggcaau                                                   20


<210>  7356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7356
auuucacuga uugagagacu                                                   20


<210>  7357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7357
uugcagcacu guggggcgau                                                   20


<210>  7358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7358
uuggaugcuc auugcagcac                                                   20


<210>  7359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7359
cguuggaugc ucauugcagc                                                   20


<210>  7360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7360
cgccuccucc aaaagccagg                                                   20


<210>  7361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7361
uccaaaagcc agggacugcu                                                   20


<210>  7362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7362
aaaagccagg gacugcuuca                                                   20


<210>  7363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7363
aggacugcug cuccagcauu                                                   20


<210>  7364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7364
agcauuuccg gcagcugcug                                                   20


<210>  7365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7365
aucugggcuu gacugugcca                                                   20


<210>  7366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7366
cucagagaga ggcacccagg                                                   20


<210>  7367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7367
gagagaggca cccagggcuc                                                   20


<210>  7368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7368
gagggaggcc cuugcuccau                                                   20


<210>  7369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7369
cugagggagg cccuugcucc                                                   20


<210>  7370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7370
cucugaggga ggcccuugcu                                                   20


<210>  7371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7371
cccuucaaag gaagcacuug                                                   20


<210>  7372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7372
aagugcuucc uuugaagggu                                                   20


<210>  7373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7373
aaggucacac aggaaacuga                                                   20


<210>  7374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7374
uauaguuuag auccaggcuu                                                   20


<210>  7375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7375
uauuucuccu auaguuuaga                                                   20


<210>  7376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7376
cccgacccau ccccaaucuu                                                   20


<210>  7377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7377
gaugggcaga agauugggga                                                   20


<210>  7378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7378
cagaugggca gaagauuggg                                                   20


<210>  7379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7379
agcguuuuga aguucaaauu                                                   20


<210>  7380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7380
agagaccugg augcaugugg                                                   20


<210>  7381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7381
ggaguaacuu acuuuuguuu                                                   20


<210>  7382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7382
uaggauggau uuuauuuucc                                                   20


<210>  7383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7383
ccuaggaugg auuuuauuuu                                                   20


<210>  7384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7384
gggcaucuau gcagaguuca                                                   20


<210>  7385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7385
gcauagaugc ccagagguaa                                                   20


<210>  7386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7386
ucacccagga auuacgugag                                                   20


<210>  7387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7387
cguaauuccu gggugaugag                                                   20


<210>  7388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7388
ucacguaauu ccugggugau                                                   20


<210>  7389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7389
ucguggcuuc ccuuguagca                                                   20


<210>  7390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7390
aauuaauaaa gcccuaagag                                                   20


<210>  7391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7391
uagggcuuua uuaauuggag                                                   20


<210>  7392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7392
uuuguaugaa auaaucuggg                                                   20


<210>  7393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7393
acuuugcauu cuucaauaaa                                                   20


<210>  7394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7394
gcaaggguua uauuucaguc                                                   20


<210>  7395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7395
cugugacgua agcuaggccc                                                   20


<210>  7396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7396
uggcuaagag gagagacuuc                                                   20


<210>  7397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7397
uagccaggag ucugggggcc                                                   20


<210>  7398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7398
ucuuagccag gagucugggg                                                   20


<210>  7399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7399
ccucuuagcc aggagucugg                                                   20


<210>  7400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7400
gcacccagcc uucugaucag                                                   20


<210>  7401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7401
gauaaaacug aucagaaggc                                                   20


<210>  7402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7402
ugguuuugcu ggggugcacu                                                   20


<210>  7403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7403
ccugguuuug cuggggugca                                                   20


<210>  7404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7404
uuguugagac uuggugauug                                                   20


<210>  7405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7405
acaaggagug aagacacgga                                                   20


<210>  7406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7406
acccagccuu ugugggguaa                                                   20


<210>  7407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7407
ccuaauugug uuauaaaaag                                                   20


<210>  7408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7408
uaauuguguu auaaaaagau                                                   20


<210>  7409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7409
gccccgcuaa acugccaagg                                                   20


<210>  7410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7410
cccagucugc cucaagguua                                                   20


<210>  7411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7411
agguuaacug aguuucauca                                                   20


<210>  7412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7412
guuaaccuug aggcagacug                                                   20


<210>  7413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7413
ggccccuucc cucuccuccc                                                   20


<210>  7414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7414
ccucccugcu gucccuaacu                                                   20


<210>  7415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7415
ucccugcugu cccuaacuuu                                                   20


<210>  7416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7416
cugcuguccc uaacuuucac                                                   20


<210>  7417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7417
ucaggaggug gcugguggcc                                                   20


<210>  7418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7418
ugaagaguga aaguuaggga                                                   20


<210>  7419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7419
agaaauaggc caccagccac                                                   20


<210>  7420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7420
ccagaaauag gccaccagcc                                                   20


<210>  7421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7421
ugggcuugag ccaacgccau                                                   20


<210>  7422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7422
agcccaagag gacgcuaugg                                                   20


<210>  7423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7423
gauggcguug gcucaagccc                                                   20


<210>  7424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7424
cagcaaacau cucauguccu                                                   20


<210>  7425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7425
gcaaacaucu cauguccuca                                                   20


<210>  7426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7426
uguccucaag ggcuggacau                                                   20


<210>  7427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7427
agggcuggac aucccuuucc                                                   20


<210>  7428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7428
gcagccaaca ucaaggugac                                                   20


<210>  7429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7429
gaugcauccc uaugcuucuu                                                   20


<210>  7430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7430
aaucauaaag guuuaacccc                                                   20


<210>  7431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7431
uuuuuagggg guuaaaccuu                                                   20


<210>  7432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7432
cuuaauucuu caaacccugc                                                   20


<210>  7433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7433
uaauucuuca aacccugcaa                                                   20


<210>  7434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7434
uucaccauuu agggcuugca                                                   20


<210>  7435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7435
ugcagugguc agaggguagg                                                   20


<210>  7436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7436
gaccacugca ugagccccuc                                                   20


<210>  7437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7437
caaguucaug ugccucccua                                                   20


<210>  7438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7438
cuaaaacgca gaucgugacu                                                   20


<210>  7439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7439
uaggucugag gagggagggg                                                   20


<210>  7440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7440
gaccuaugag ucacgaucug                                                   20


<210>  7441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7441
ucagaccuau gagucacgau                                                   20


<210>  7442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7442
cuccucagac cuaugaguca                                                   20


<210>  7443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7443
guggcucuac gguccacaca                                                   20


<210>  7444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7444
acgguccaca cacgauccca                                                   20


<210>  7445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7445
ugugggaucg uguguggacc                                                   20


<210>  7446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7446
ggcggggagc ucccuucacc                                                   20


<210>  7447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7447
ccgccagaga cucauguggg                                                   20


<210>  7448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7448
cuucacccag aacccccagg                                                   20


<210>  7449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7449
ccuggggguu cugggugaag                                                   20


<210>  7450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7450
gaagccuucc ucaccugggg                                                   20


<210>  7451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7451
cagaagccuu ccucaccugg                                                   20


<210>  7452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7452
gcccccucuc agaagccuuc                                                   20


<210>  7453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7453
gcucugcccc cucucagaag                                                   20


<210>  7454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7454
ucuguggagc ccauggggau                                                   20


<210>  7455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7455
acagaugagg acaccggccc                                                   20


<210>  7456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7456
agguggucau ccccaugggc                                                   20


<210>  7457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7457
gugugucucc agguggucau                                                   20


<210>  7458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7458
cagugacacc cugagaggga                                                   20


<210>  7459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7459
gugacacccu gagagggaau                                                   20


<210>  7460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7460
gggugucacu gagaggaugc                                                   20


<210>  7461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7461
caggguguca cugagaggau                                                   20


<210>  7462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7462
aggguggcag gaaggccacu                                                   20


<210>  7463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7463
uucccugggu ggcacaaaca                                                   20


<210>  7464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7464
uggggaagug cgucuucucc                                                   20


<210>  7465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7465
ucuccaaacc acaggcucac                                                   20


<210>  7466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7466
ccaaaccaca ggcucacaag                                                   20


<210>  7467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7467
aaaccacagg cucacaagca                                                   20


<210>  7468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7468
caagcagacc agcucaagug                                                   20


<210>  7469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7469
agugaaguuc cugcaaugac                                                   20


<210>  7470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7470
gcaggggccg gaaaagcagg                                                   20


<210>  7471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7471
cagcaggggc cggaaaagca                                                   20


<210>  7472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7472
gggaccccuc ucagcagggg                                                   20


<210>  7473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7473
cagggacccc ucucagcagg                                                   20


<210>  7474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7474
cucagggacc ccucucagca                                                   20


<210>  7475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7475
uggaccucuc ucagggaccc                                                   20


<210>  7476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7476
cccacccgga gccaacucgc                                                   20


<210>  7477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7477
ggguggggga ggcugggguu                                                   20


<210>  7478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7478
ccuccagcac acgggcgcug                                                   20


<210>  7479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7479
agcacacggg cgcugugccu                                                   20


<210>  7480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7480
cagccuaagc caggaaagaa                                                   20


<210>  7481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7481
aauuuaagug ucagcguaca                                                   20


<210>  7482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7482
caauuaucuc ucaaucccgg                                                   20


<210>  7483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7483
caaucccggc uugcccugug                                                   20


<210>  7484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7484
aucccggcuu gcccugugcu                                                   20


<210>  7485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7485
cccucguuuu aaguacauug                                                   20


<210>  7486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7486
uuuuaaguac auugugcaua                                                   20


<210>  7487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7487
auuugcaucu uauaauaagg                                                   20


<210>  7488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7488
gccauaaacc aguaugauaa                                                   20


<210>  7489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7489
uuaguuuuua ucucucuggg                                                   20


<210>  7490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7490
cuggggcuag auucccccuc                                                   20


<210>  7491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7491
ggggcuagau ucccccucau                                                   20


<210>  7492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7492
ugaguucaau auaaguccau                                                   20


<210>  7493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7493
ugagggggaa ucuagcccca                                                   20


<210>  7494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7494
uaaggguguu aauguuaaca                                                   20


<210>  7495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7495
ccaaagugua cagaauguuu                                                   20


<210>  7496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7496
agugaaugca aacauucugu                                                   20


<210>  7497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7497
gugauagcug ugguugcuca                                                   20


<210>  7498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7498
uaagugaaag gaguugaguc                                                   20


<210>  7499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7499
uuucacuuau gagcaaccac                                                   20


<210>  7500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7500
acuccuuuca cuuaugagca                                                   20


<210>  7501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7501
uugcacugag acauaaucuc                                                   20


<210>  7502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7502
gugcaaagag gugaaaaagg                                                   20


<210>  7503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7503
gguguguuca uucucuuaca                                                   20


<210>  7504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7504
uacauuuaga uuaauuauaa                                                   20


<210>  7505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7505
ggaaaaugca uaauuucccu                                                   20


<210>  7506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7506
ugguuguuuu uuuuuuuuuu                                                   20


<210>  7507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7507
cuucuuugga accaagcuga                                                   20


<210>  7508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7508
uaucaucucc cuucuuugga                                                   20


<210>  7509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7509
ccuaucaucu cccuucuuug                                                   20


<210>  7510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7510
cccucuccua ucaucucccu                                                   20


<210>  7511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7511
accacccagc uguguuaggc                                                   20


<210>  7512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7512
uacccucugu acaggcccaa                                                   20


<210>  7513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7513
guacaggccc aacacacaug                                                   20


<210>  7514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7514
aguccucuca cuugcuucag                                                   20


<210>  7515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7515
cacuugcuuc agauuuucca                                                   20


<210>  7516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7516
cuugcuucag auuuuccaag                                                   20


<210>  7517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7517
acugcagcca uacaccccgg                                                   20


<210>  7518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7518
gggguguaug gcugcaguag                                                   20


<210>  7519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7519
guguugauuc agaugauucc                                                   20


<210>  7520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7520
ccuugcuggc aguggcugaa                                                   20


<210>  7521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7521
uugcuggcag uggcugaaau                                                   20


<210>  7522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7522
gggggcugcu ccuggggauu                                                   20


<210>  7523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7523
uggggauugg uuaccucccu                                                   20


<210>  7524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7524
cucuagauac ugggcuccau                                                   20


<210>  7525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7525
agauacuggg cuccauccuu                                                   20


<210>  7526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7526
auccuuggcu guguugguua                                                   20


<210>  7527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7527
gcugguaacg acacuugguu                                                   20


<210>  7528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7528
uguccuucga ggucucucuc                                                   20


<210>  7529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7529
aaggacagga gcccuccgcu                                                   20


<210>  7530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7530
cuccaggucu ccacagguga                                                   20


<210>  7531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7531
ccaggucucc acaggugaaa                                                   20


<210>  7532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7532
aggucuccac aggugaaacu                                                   20


<210>  7533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7533
acaggugaaa cuuuuccacg                                                   20


<210>  7534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7534
uucugcuauu acugugauua                                                   20


<210>  7535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7535
aacccauccg ucuucccagc                                                   20


<210>  7536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7536
cugggcaagu ugguaacccc                                                   20


<210>  7537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7537
guguguuuua aaacuaaaau                                                   20


<210>  7538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7538
ucaaggccuc cuacgucucu                                                   20


<210>  7539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7539
uacgucucuc ugaccucuac                                                   20


<210>  7540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7540
cugaccucua cccucugcuc                                                   20


<210>  7541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7541
gaccucuacc cucugcucuu                                                   20


<210>  7542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7542
acccucugcu cuucgaaaau                                                   20


<210>  7543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7543
gcucuucgaa aauauacugg                                                   20


<210>  7544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7544
ucgaaaauau acuggaugug                                                   20


<210>  7545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7545
caaccccaaa aggcucaaag                                                   20


<210>  7546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7546
accccaaaag gcucaaaguc                                                   20


<210>  7547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7547
aagucuugua gcuuaauuac                                                   20


<210>  7548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7548
guguugcaaa uggaaaggua                                                   20


<210>  7549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7549
uacuggaaau cacauugaau                                                   20


<210>  7550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7550
ccuacuggaa aucacauuga                                                   20


<210>  7551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7551
agcccacccc acaucuguuc                                                   20


<210>  7552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7552
uggccuaggg gguccuugug                                                   20


<210>  7553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7553
ccuggccuag gggguccuug                                                   20


<210>  7554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7554
aggagaagag ugggagccca                                                   20


<210>  7555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7555
uggaguuaaa gguaaaggcu                                                   20


<210>  7556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7556
ucuccuggag uuaaagguaa                                                   20


<210>  7557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7557
cacucuucuc cuggaguuaa                                                   20


<210>  7558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7558
gggcucccac ucuucuccug                                                   20


<210>  7559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7559
gaagcuguau ucacucuggg                                                   20


<210>  7560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7560
aguuucugua gucuuauccu                                                   20


<210>  7561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7561
augacauuac uggccuugau                                                   20


<210>  7562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7562
ucuguaacga cuaugacgau                                                   20


<210>  7563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7563
ugggcaaaau ggaaaagaac                                                   20


<210>  7564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7564
gcaaaacaua aucacuaaaa                                                   20


<210>  7565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7565
ucaugucagc acaaggcuua                                                   20


<210>  7566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7566
cagacuucau cucacacagg                                                   20


<210>  7567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7567
cacaggccuu gcuuuccucc                                                   20


<210>  7568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7568
cuguccccac ucaaggucua                                                   20


<210>  7569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7569
aggucuauac cucacuuuuu                                                   20


<210>  7570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7570
cuuuuucauu acacuuuacu                                                   20


<210>  7571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7571
cacugaaaua uaguaaagug                                                   20


<210>  7572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7572
gcuauuacca ggacgcccca                                                   20


<210>  7573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7573
ggggaacacu uccaugugug                                                   20


<210>  7574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7574
gacgccuccc ggccguucuc                                                   20


<210>  7575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7575
cggccguucu cuugugacug                                                   20


<210>  7576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7576
ugugacugau ccuuagcauu                                                   20


<210>  7577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7577
uaggccaccg uccugaggug                                                   20


<210>  7578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7578
ggacgguggc cuaggagcaa                                                   20


<210>  7579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7579
gcaaugccca cccugcaaca                                                   20


<210>  7580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7580
ugugaccugc cauggccaca                                                   20


<210>  7581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7581
acuccuguga ccugccaugg                                                   20


<210>  7582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7582
guggucucca cuccugugac                                                   20


<210>  7583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7583
gggagaaacu cuaggaugaa                                                   20


<210>  7584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7584
cagagcucug uggucuccac                                                   20


<210>  7585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7585
aggaugaaau agagaguuug                                                   20


<210>  7586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7586
auuucauccu agaguuucuc                                                   20


<210>  7587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7587
cuauuucauc cuagaguuuc                                                   20


<210>  7588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7588
uggaagcagg acuagucuau                                                   20


<210>  7589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7589
cccaugccua cuauccuguu                                                   20


<210>  7590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7590
cccccaugcc uacuauccug                                                   20


<210>  7591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7591
cucccccaug ccuacuaucc                                                   20


<210>  7592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7592
auuuuugaaa ugcaagcucc                                                   20


<210>  7593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7593
aagagaguga agccccagcc                                                   20


<210>  7594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7594
uggagcuugc auuucaaaaa                                                   20


<210>  7595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7595
cuuggagcuu gcauuucaaa                                                   20


<210>  7596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7596
gcacaaagua aggcagugca                                                   20


<210>  7597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7597
uauuuguaaa aguuacauua                                                   20


<210>  7598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7598
cgccuauaau cccagcaccu                                                   20


<210>  7599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7599
ccaggugcug ggauuauagg                                                   20


<210>  7600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7600
ugccuuggcc uccccaggug                                                   20


<210>  7601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7601
uggcuucaaa ugauccuccu                                                   20


<210>  7602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7602
aacuccuggc uucaaaugau                                                   20


<210>  7603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7603
ccucaaaaaa gaaguauuug                                                   20


<210>  7604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7604
aaaaagaagu auuuguaccu                                                   20


<210>  7605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7605
cugaucugca aaaaucuugu                                                   20


<210>  7606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7606
gaucugcaaa aaucuuguag                                                   20


<210>  7607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7607
aagcaaaaug auaaaccuaa                                                   20


<210>  7608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7608
uuaagcacuu aacacuuuag                                                   20


<210>  7609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7609
aggucuuuau cuuuaggcug                                                   20


<210>  7610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7610
uggcuuguuu ugaauucccu                                                   20


<210>  7611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7611
uccaaaacuu uucuauggac                                                   20


<210>  7612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7612
cuccuguaau cccagcacuu                                                   20


<210>  7613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7613
uguaauccca gcacuuuggg                                                   20


<210>  7614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7614
caaagugcug ggauuacagg                                                   20


<210>  7615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7615
gccucccaaa gugcugggau                                                   20


<210>  7616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7616
ggcgauccac ccgccucagc                                                   20


<210>  7617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7617
ugaccucagg cgauccaccc                                                   20


<210>  7618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7618
acuaaaaaua caaaaaauua                                                   20


<210>  7619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7619
ggaggcugag gcaggagaau                                                   20


<210>  7620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7620
cgaguagcug gaauuacagg                                                   20


<210>  7621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7621
gccucccgag uagcuggaau                                                   20


<210>  7622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7622
ugccucagcc ucccgaguag                                                   20


<210>  7623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7623
cagguuccag caauucuccu                                                   20


<210>  7624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7624
gccucccagg uuccagcaau                                                   20


<210>  7625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7625
cugcaaccuc cgccucccag                                                   20


<210>  7626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7626
agcuugggca acaagaguga                                                   20


<210>  7627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7627
uguugcccaa gcuagagugc                                                   20


<210>  7628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7628
gucucaaaaa aaaaaaaaaa                                                   20


<210>  7629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7629
aaaaaaaaaa aaaaaaaaag                                                   20


<210>  7630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7630
auaacauggc cccaaauuag                                                   20


<210>  7631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7631
uccugccaua cuggucuggu                                                   20


<210>  7632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7632
agacacugca guacugccuu                                                   20


<210>  7633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7633
cugucaucua aauucuagcc                                                   20


<210>  7634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7634
gucaucuaaa uucuagccug                                                   20


<210>  7635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7635
gugggccuca gagaaauuau                                                   20


<210>  7636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7636
gagaaauuau cuuccucugc                                                   20


<210>  7637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7637
gaggcccaca gagauguuag                                                   20


<210>  7638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7638
gcauuccucc aguuggcauc                                                   20


<210>  7639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7639
aguuggcauc ucucacuaau                                                   20


<210>  7640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7640
cacuaaugga uuaaucauau                                                   20


<210>  7641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7641
cuaauggauu aaucauauua                                                   20


<210>  7642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7642
ccuauuguua ugugcuuuua                                                   20


<210>  7643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7643
uauuguuaug ugcuuuuaug                                                   20


<210>  7644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7644
aagggauuac aguugguccu                                                   20


<210>  7645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7645
aggcacgugg ggaacuauaa                                                   20


<210>  7646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7646
ugcacacugu aggcuggggg                                                   20


<210>  7647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7647
gaucaucagc auaagcaaau                                                   20


<210>  7648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7648
uguuugcagu auuaucuuuc                                                   20


<210>  7649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7649
aacugauuac cugccacuaa                                                   20


<210>  7650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7650
uaucuuuaca aagauugugu                                                   20


<210>  7651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7651
uucuaaauca uugguguugu                                                   20


<210>  7652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7652
cauauuuggc ccaguccuuc                                                   20


<210>  7653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7653
ucccuaccau uugaaaaaca                                                   20


<210>  7654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7654
ggaaugaaug ggaacguuau                                                   20


<210>  7655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7655
ggcccuuugc cugggacugc                                                   20


<210>  7656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7656
ccguaccagc uuaacugcaa                                                   20


<210>  7657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7657
acugguagca auuucugaug                                                   20


<210>  7658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7658
uugcaucccu uccccagcac                                                   20


<210>  7659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7659
gcagguugca uauagcagga                                                   20


<210>  7660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7660
uucauuuguu caaucaacaa                                                   20


<210>  7661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7661
aucugccgua uggcucauuc                                                   20


<210>  7662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7662
aguauucucc aucugccgua                                                   20


<210>  7663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7663
ccaguauucu ccaucugccg                                                   20


<210>  7664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7664
gauaugccuc acaaaaccau                                                   20


<210>  7665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7665
caaaaccaua ccgguccucc                                                   20


<210>  7666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7666
cagcaucaga aauggacaga                                                   20


<210>  7667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7667
auagucugca gaaccagagc                                                   20


<210>  7668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7668
gguucugcag acuauggagc                                                   20


<210>  7669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7669
aagcaaaacc acuuugaaua                                                   20


<210>  7670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7670
gcauuggcau uacaaguggu                                                   20


<210>  7671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7671
uccugaaauu uucuuaccac                                                   20


<210>  7672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7672
uaguaucuac cucauccuga                                                   20


<210>  7673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7673
accuuuugac uccuaguauc                                                   20


<210>  7674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7674
caaccucuac cuuuugacuc                                                   20


<210>  7675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7675
cuaagcuuaa guagaaugaa                                                   20


<210>  7676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7676
aagcuuaagu agaaugaaaa                                                   20


<210>  7677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7677
augcauguuc uuauuucuuc                                                   20


<210>  7678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7678
cgucuguaau cccagcacuu                                                   20


<210>  7679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7679
caaagugcug ggauuacaga                                                   20


<210>  7680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7680
ggugauccac ccaccuuggc                                                   20


<210>  7681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7681
ugaccucagg ugauccaccc                                                   20


<210>  7682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7682
aacuccugac cucaggugau                                                   20


<210>  7683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7683
acuaaaaaua uaaaaauuag                                                   20


<210>  7684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7684
ggaggcugag guaggagaau                                                   20


<210>  7685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7685
agaguagcug ggauuauagg                                                   20


<210>  7686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7686
gccuccagag uagcugggau                                                   20


<210>  7687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7687
uaccucagcc uccagaguag                                                   20


<210>  7688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7688
cggauucaag caauucuccu                                                   20


<210>  7689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7689
gccucccgga uucaagcaau                                                   20


<210>  7690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7690
cugcaaccuc cgccucccgg                                                   20


<210>  7691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7691
gcucacugca accuccgccu                                                   20


<210>  7692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7692
agccugggca acaauagcaa                                                   20


<210>  7693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7693
aucucaaaaa aaaaaaaaag                                                   20


<210>  7694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7694
aaaaaaaaaa aaagaacaug                                                   20


<210>  7695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7695
auaaacauua gcugauauga                                                   20


<210>  7696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7696
uuaccaagcu cugggcaguc                                                   20


<210>  7697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7697
gggcagucug ccaaucaagg                                                   20


<210>  7698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7698
uccuugauug gcagacugcc                                                   20


<210>  7699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7699
gucagagauc acauuucaga                                                   20


<210>  7700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7700
gacugagaac cuaacccuuc                                                   20


<210>  7701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7701
aggcacccga agaaguuugg                                                   20


<210>  7702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7702
gugagaugcc gaggcccugu                                                   20


<210>  7703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7703
cugagggugg caaagcacca                                                   20


<210>  7704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7704
gcaucucacu gaggguggca                                                   20


<210>  7705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7705
augcuacccu ccagcaggaa                                                   20


<210>  7706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7706
agcaggaaaa ggggugaaga                                                   20


<210>  7707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7707
ucaccccuuu uccugcugga                                                   20


<210>  7708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7708
gggugcaucu uaucacuuug                                                   20


<210>  7709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7709
agucccaaga ggccggaaca                                                   20


<210>  7710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7710
ugggacugga guguugacau                                                   20


<210>  7711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7711
cacugcugug acuguugcgu                                                   20


<210>  7712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7712
uacuucccag cagcacgcaa                                                   20


<210>  7713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7713
gaaaaaggaa ggacacaauc                                                   20


<210>  7714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7714
cucugaaaaa ggaaggacac                                                   20


<210>  7715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7715
uucugcaugu gacacauuca                                                   20


<210>  7716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7716
ggguuaugau cuuggcuuua                                                   20


<210>  7717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7717
gagaacagca ccauuuacca                                                   20


<210>  7718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7718
gagcccacag cucaggguua                                                   20


<210>  7719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7719
uccugccccc aacacauagg                                                   20


<210>  7720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7720
gacacaggcc uauguguugg                                                   20


<210>  7721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7721
cagagaagcu gaaaaauaaa                                                   20


<210>  7722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7722
gagaagcuga aaaauaaaaa                                                   20


<210>  7723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7723
gagagcacau uuucuuuucc                                                   20


<210>  7724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7724
uuuuauuuuu cagcuucucu                                                   20


<210>  7725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7725
uguguuccug aguucugagc                                                   20


<210>  7726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7726
ggaacacaag agauuuuucu                                                   20


<210>  7727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7727
gaacucagga acacaagaga                                                   20


<210>  7728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7728
cccaaagcuc agaacucagg                                                   20


<210>  7729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7729
ucagaaacuc acccaaagcu                                                   20


<210>  7730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7730
gaaauagaag caugaguaac                                                   20


<210>  7731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7731
ugcuucuauu ucagagugac                                                   20


<210>  7732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7732
aagauuugca guuacucaug                                                   20


<210>  7733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7733
uccuaccucu caauuggcuu                                                   20


<210>  7734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7734
caauuggcuu ucuacguauu                                                   20


<210>  7735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7735
auuggcuuuc uacguauucu                                                   20


<210>  7736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7736
ucuagaauac guagaaagcc                                                   20


<210>  7737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7737
cugcugauuu gucccucuuc                                                   20


<210>  7738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7738
cccugcugau uugucccucu                                                   20


<210>  7739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7739
cucccugcug auuugucccu                                                   20


<210>  7740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7740
cgcugccauu ucugaaccuu                                                   20


<210>  7741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7741
gaccauccuc aacagggaug                                                   20


<210>  7742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7742
acagggaugu uugauuugcu                                                   20


<210>  7743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7743
gugaggcuuc ccgcugucuu                                                   20


<210>  7744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7744
cugagcaaca gcaaaucaaa                                                   20


<210>  7745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7745
uauuucaggg agggcuuugc                                                   20


<210>  7746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7746
cugaaauagg agaaagacag                                                   20


<210>  7747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7747
aaacagcugc ugcgcacagc                                                   20


<210>  7748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7748
guggccauuu cuuuucuugc                                                   20


<210>  7749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7749
cgccuguaau cccagcacuu                                                   20


<210>  7750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7750
caaagugcug ggauuacagg                                                   20


<210>  7751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7751
ggugauucgc ccaccuuggc                                                   20


<210>  7752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7752
ugaccucagg ugauucgccc                                                   20


<210>  7753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7753
aacuccugac cucaggugau                                                   20


<210>  7754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7754
auuucuacua aaaauacaaa                                                   20


<210>  7755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7755
ggaggcugag gcaggggaau                                                   20


<210>  7756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7756
ugaguagcug gaacuacagg                                                   20


<210>  7757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7757
gccuccugag uagcuggaac                                                   20


<210>  7758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7758
cugguucaag ugauuccccu                                                   20


<210>  7759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7759
gccucccugg uucaagugau                                                   20


<210>  7760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7760
ccgcaaccuc ugccucccug                                                   20


<210>  7761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7761
gcucaccgca accucugccu                                                   20


<210>  7762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7762
agccugggag acagggugag                                                   20


<210>  7763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7763
caggcuggag ugcaguggcg                                                   20


<210>  7764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7764
cccugucucc caggcuggag                                                   20


<210>  7765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7765
aucucaaaaa aaaaaaagaa                                                   20


<210>  7766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7766
aaaaaaaaaa agaaagaaaa                                                   20


<210>  7767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7767
aacaggaugu gauguggcau                                                   20


<210>  7768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7768
uauaucuugu cuagagaaug                                                   20


<210>  7769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7769
agacaagaua uaagagaaac                                                   20


<210>  7770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7770
caaucuguuc cauucucuag                                                   20


<210>  7771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7771
aaugacuuaa gugggucuca                                                   20


<210>  7772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7772
ucaaaccaaa uucaucucca                                                   20


<210>  7773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7773
cagcaauucu uggucuccag                                                   20


<210>  7774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7774
gcaauucuug gucuccaggu                                                   20


<210>  7775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7775
agguuuauuu cuaccguugg                                                   20


<210>  7776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7776
aacgguagaa auaaaccugg                                                   20


<210>  7777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7777
gucauaggaa uacuauuuua                                                   20


<210>  7778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7778
cuagugaccc acuaaauuca                                                   20


<210>  7779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7779
cccuagugac ccacuaaauu                                                   20


<210>  7780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7780
ugugcaaagg aauucaagug                                                   20


<210>  7781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7781
cagcuccugu gcaaaggaau                                                   20


<210>  7782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7782
gccacuaacu gugugguuuc                                                   20


<210>  7783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7783
aaaaugagug auuacuagga                                                   20


<210>  7784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7784
uuuuagagau cagaauaaua                                                   20


<210>  7785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7785
caggaaguac uuaagcuuua                                                   20


<210>  7786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7786
cuuccaguaa aauccagaag                                                   20


<210>  7787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7787
aggggaaugc aaacugaaga                                                   20


<210>  7788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7788
ucaguuugca uuccccugga                                                   20


<210>  7789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7789
ccuaggcagu cagaggaaag                                                   20


<210>  7790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7790
uaggcaguca gaggaaagaa                                                   20


<210>  7791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7791
gacugccuag gagagacagu                                                   20


<210>  7792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7792
gcugguuagg aacucaagau                                                   20


<210>  7793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7793
agaugaacuc uugaagaagg                                                   20


<210>  7794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7794
ugaagaagga aggugugcuu                                                   20


<210>  7795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7795
aaauuccuca aaucugcuuc                                                   20


<210>  7796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7796
aaucugcuuc cuucacacua                                                   20


<210>  7797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7797
aaaaggaguc aaagcuaugu                                                   20


<210>  7798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7798
uuuuggagua uagugugaag                                                   20


<210>  7799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7799
cuaucaaaaa aaaaaaaaaa                                                   20


<210>  7800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7800
uggaaacucc aagcaaaagu                                                   20


<210>  7801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7801
aagcaaaagu gcccagaaaa                                                   20


<210>  7802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7802
guuagaccuc agcagauucc                                                   20


<210>  7803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7803
gcagauucca agauugcacu                                                   20


<210>  7804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7804
uugccuaaga guuuucuuua                                                   20


<210>  7805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7805
uaggcaagga gugcaaucuu                                                   20


<210>  7806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7806
aacaggcuga uauucaacau                                                   20


<210>  7807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7807
aagccccugc agcacccagc                                                   20


<210>  7808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7808
cccaucaugg accccaauuc                                                   20


<210>  7809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7809
caucauggac cccaauucua                                                   20


<210>  7810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7810
caaagugcug ggauuacagg                                                   20


<210>  7811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7811
gccucccaaa gugcugggau                                                   20


<210>  7812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7812
ugaggucagg aguucgagac                                                   20


<210>  7813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7813
ugagccaccu gccucggccu                                                   20


<210>  7814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7814
ugaccucaug agccaccugc                                                   20


<210>  7815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7815
aacuccugac cucaugagcc                                                   20


<210>  7816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7816
acuaaaaaua caaaaauuag                                                   20


<210>  7817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7817
ggaggcugag gcaggagaac                                                   20


<210>  7818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7818
ugaguggcug ggauuacagg                                                   20


<210>  7819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7819
gccuccugag uggcugggau                                                   20


<210>  7820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7820
ugccucagcc uccugagugg                                                   20


<210>  7821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7821
cggguucaag ugguucuccu                                                   20


<210>  7822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7822
accucccggg uucaaguggu                                                   20


<210>  7823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7823
cugcaaccuc uaccucccgg                                                   20


<210>  7824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7824
agccugggca auagagugag                                                   20


<210>  7825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7825
auugcccagg cuggagugca                                                   20


<210>  7826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7826
cucuauugcc caggcuggag                                                   20


<210>  7827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7827
aucucaacaa uaauaauaau                                                   20


<210>  7828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7828
acaauaauaa uaauaauaau                                                   20


<210>  7829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7829
uccauccaag uggcugggac                                                   20


<210>  7830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7830
auccaagugg cugggacucu                                                   20


<210>  7831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7831
guccucuagu cugugcucau                                                   20


<210>  7832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7832
agucugugcu caugucaggc                                                   20


<210>  7833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7833
ugucaggcaa ccaauuuauc                                                   20


<210>  7834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7834
cugcaaucug aaguuccacu                                                   20


<210>  7835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7835
gcaaucugaa guuccacucu                                                   20


<210>  7836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7836
gcagagagga cacagugaga                                                   20


<210>  7837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7837
gcagagugga acuucagauu                                                   20


<210>  7838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7838
cugcagagug gaacuucaga                                                   20


<210>  7839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7839
cuguguccuc ucugcagagu                                                   20


<210>  7840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7840
caaaucugcc agggguucuc                                                   20


<210>  7841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7841
ucccugcuuc ugccauucau                                                   20


<210>  7842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7842
ucacacagag agaugucuuc                                                   20


<210>  7843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7843
gugugaugag ucaagaucau                                                   20


<210>  7844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7844
cugugugaug agucaagauc                                                   20


<210>  7845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7845
ccuggccuag ggcuagacuu                                                   20


<210>  7846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7846
aaucccagca cuaugggagg                                                   20


<210>  7847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7847
cauagugcug ggauuagagg                                                   20


<210>  7848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7848
uaggccuccc auagugcugg                                                   20


<210>  7849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7849
ugauccaccc uccuaggccu                                                   20


<210>  7850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7850
ugaucucgug auccacccuc                                                   20


<210>  7851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7851
aucuccugau cucgugaucc                                                   20


<210>  7852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7852
gcuucccaag uagcugggac                                                   20


<210>  7853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7853
ugccucagcu ucccaaguag                                                   20


<210>  7854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7854
gccuacuggg uucaagggau                                                   20


<210>  7855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7855
ccacaaccuc cgccuacugg                                                   20


<210>  7856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7856
gcucaccaca accuccgccu                                                   20


<210>  7857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7857
agccugggug acagagcgag                                                   20


<210>  7858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7858
gucacccagg cuggagugca                                                   20


<210>  7859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7859
cucugucacc caggcuggag                                                   20


<210>  7860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7860
aaacaaacag aacaaaaaga                                                   20


<210>  7861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7861
acagugaaga ggauaaaaca                                                   20


<210>  7862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7862
ucacugugga gaagaacccc                                                   20


<210>  7863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7863
ugccccuuaa aaaucccacu                                                   20


<210>  7864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7864
aaaaguggga uuuuuaaggg                                                   20


<210>  7865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7865
gagaagaaau auauaaaaag                                                   20


<210>  7866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7866
gagucaguuu guaaauaagu                                                   20


<210>  7867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7867
agacccagga uuguuguuuc                                                   20


<210>  7868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7868
cuuuggaagu ggugucacuc                                                   20


<210>  7869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7869
uucuaggcau cagcaaggag                                                   20


<210>  7870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7870
uugcugaugc cuagaaagag                                                   20


<210>  7871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7871
cuaaaugugc ugaacuccuu                                                   20


<210>  7872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7872
gccuaugugu ugcugaaaca                                                   20


<210>  7873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7873
cugccccaug cucugccuau                                                   20


<210>  7874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7874
cccugcccca ugcucugccu                                                   20


<210>  7875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7875
ugcaaucagg guuauuuguc                                                   20


<210>  7876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7876
uugccaucac cuuuccccug                                                   20


<210>  7877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7877
cuuucucagu gcacacaucu                                                   20


<210>  7878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7878
gugcacacau cuguugguag                                                   20


<210>  7879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7879
uccuaccaac agaugugugc                                                   20


<210>  7880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7880
gcaugccuuu accaaaggcc                                                   20


<210>  7881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7881
cuuugaucag uuaaacagag                                                   20


<210>  7882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7882
guuuaacuga ucaaagggag                                                   20


<210>  7883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7883
ggacaagaaa ccagaaaacc                                                   20


<210>  7884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7884
gcuuucucuc uuacugaugu                                                   20


<210>  7885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7885
cuuacugaug uggccucugg                                                   20


<210>  7886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7886
uacugaugug gccucuggca                                                   20


<210>  7887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7887
ggcaagcccu uaaccuuggu                                                   20


<210>  7888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7888
aucuccaccu ccauaaagua                                                   20


<210>  7889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7889
accuccauaa aguagaaguc                                                   20


<210>  7890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7890
auaaaguaga agucgugaga                                                   20


<210>  7891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7891
cgacuucuac uuuauggagg                                                   20


<210>  7892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7892
gggacagauc ucacgacuuc                                                   20


<210>  7893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7893
cugggacaga ucucacgacu                                                   20


<210>  7894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7894
ugcauuauuu caccugcucu                                                   20


<210>  7895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7895
gacaccugug ugcuguagau                                                   20


<210>  7896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7896
auuauugaca aaccuauuuu                                                   20


<210>  7897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7897
ucuggaucuc caagcaguaa                                                   20


<210>  7898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7898
aagcaguaaa aaauaccaaa                                                   20


<210>  7899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7899
guuugguauu uuuuacugcu                                                   20


<210>  7900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7900
auuccuuaga aauuagugcc                                                   20


<210>  7901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7901
uauaauuucc ccccucuaaa                                                   20


<210>  7902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7902
aaaaucugcc ccaaauuucc                                                   20


<210>  7903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7903
cccagugaug uucuuuccua                                                   20


<210>  7904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7904
uugaaaauuu augccaucug                                                   20


<210>  7905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7905
uacaucuccu gcccauuucu                                                   20


<210>  7906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7906
ugcccauuuc ucaaaucugu                                                   20


<210>  7907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7907
aaucuguucc uccuacccac                                                   20


<210>  7908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7908
uacccacccg augggugucu                                                   20


<210>  7909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7909
uugucuuaua agcauuaaaa                                                   20


<210>  7910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7910
aacauuuauu gugucaaugu                                                   20


<210>  7911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7911
ugcgcauuuc cacaauacag                                                   20


<210>  7912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7912
ugacagcgau gguccacggg                                                   20


<210>  7913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7913
cuaugggacu gauucacugu                                                   20


<210>  7914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7914
augggacuga uucacuguuc                                                   20


<210>  7915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7915
gcaggacucu gucuucgcac                                                   20


<210>  7916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7916
gucuucgcac aacggcuucu                                                   20


<210>  7917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7917
aagaagccgu ugugcgaaga                                                   20


<210>  7918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7918
gaacuuaagg gcucucgagc                                                   20


<210>  7919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7919
cgagcuucca uccgaaaacu                                                   20


<210>  7920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7920
agcuuccauc cgaaaacugc                                                   20


<210>  7921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7921
agagcccuua aguucugaga                                                   20


<210>  7922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7922
agaugugugg caguuuucgg                                                   20


<210>  7923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7923
cuggguacua cgccgaaugg                                                   20


<210>  7924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7924
ggguacuacg ccgaaugggg                                                   20


<210>  7925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7925
uucuagguuc uucacacacc                                                   20


<210>  7926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7926
aaccucuuuc uagguucuuc                                                   20


<210>  7927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7927
gucuccaacc ucuuucuagg                                                   20


<210>  7928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7928
ucugucucca accucuuucu                                                   20


<210>  7929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7929
aacuagcuuu uuaaaaauua                                                   20


<210>  7930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7930
accugugguu gguuuaaguu                                                   20


<210>  7931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7931
gccuccccuc cccaaguauc                                                   20


<210>  7932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7932
ccuccccaag uaucucugac                                                   20


<210>  7933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7933
ccaaguaucu cugaccucug                                                   20


<210>  7934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7934
gaccucugag ucgucuuccc                                                   20


<210>  7935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7935
gagucgucuu cccaugccuc                                                   20


<210>  7936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7936
gaggucagag auacuugggg                                                   20


<210>  7937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7937
cucccuuccg uccccccaag                                                   20


<210>  7938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7938
cuuccguccc cccaaggagg                                                   20


<210>  7939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7939
uuggggggac ggaagggagg                                                   20


<210>  7940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7940
ggacacaccu ggaaggaaac                                                   20


<210>  7941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7941
gucauaaggg caaguguuuc                                                   20


<210>  7942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7942
accaaaggac uguuucuuac                                                   20


<210>  7943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7943
ucaaccaaag gacuguuucu                                                   20


<210>  7944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7944
ccucaaccaa aggacuguuu                                                   20


<210>  7945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7945
cgcucuccuc aaccaaagga                                                   20


<210>  7946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7946
cccgcucucc ucaaccaaag                                                   20


<210>  7947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7947
cucucccgcu cuccucaacc                                                   20


<210>  7948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7948
ucccucuccc gcucuccuca                                                   20


<210>  7949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7949
aaauaauaau aaaauuauaa                                                   20


<210>  7950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7950
uguaaaucau uggcugcuuu                                                   20


<210>  7951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7951
gaagagaaaa ccagaaccca                                                   20


<210>  7952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7952
ucagagauuu guucgccucu                                                   20


<210>  7953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7953
uuuggguucu gguuuucucu                                                   20


<210>  7954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7954
caaauugcac caaaaacugc                                                   20


<210>  7955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7955
aauugcacca aaaacugccu                                                   20


<210>  7956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7956
cuucuucccu ucaccauugc                                                   20


<210>  7957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7957
gggguuccuc ccuugcugug                                                   20


<210>  7958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7958
cuugcugugg acauugacuu                                                   20


<210>  7959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7959
caguucugcu gcuucaaguc                                                   20


<210>  7960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7960
gcacauccgg acucccaguu                                                   20


<210>  7961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7961
uccucggcac auccggacuc                                                   20


<210>  7962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7962
uugccauggc gacccgaagc                                                   20


<210>  7963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7963
ucuccccuga cuuggcgccg                                                   20


<210>  7964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7964
ccccugacuu ggcgccgcag                                                   20


<210>  7965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7965
ccugacuugg cgccgcagga                                                   20


<210>  7966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7966
ugcggcgcca agucagggga                                                   20


<210>  7967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7967
gcugcucuca cgcaucccac                                                   20


<210>  7968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7968
cacgcauccc accccugagc                                                   20


<210>  7969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7969
cgcaucccac cccugagcag                                                   20


<210>  7970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7970
ggggugggau gcgugagagc                                                   20


<210>  7971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7971
gcucaggggu gggaugcgug                                                   20


<210>  7972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7972
gcugcucugc ucaggggugg                                                   20


<210>  7973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7973
gcccaggucu ccgcugcucu                                                   20


<210>  7974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7974
acgacaguga cuuagcgcug                                                   20


<210>  7975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7975
cgcuuuagag gauacuuggg                                                   20


<210>  7976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7976
aaagcgggag ccccuaaacc                                                   20


<210>  7977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7977
cuugaaauag uuuuugccac                                                   20


<210>  7978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7978
augguugauc caaauacguu                                                   20


<210>  7979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7979
aguacaauga cccgugugaa                                                   20


<210>  7980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7980
uucccauuug gaagggagga                                                   20


<210>  7981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7981
cuuccaaaug ggaaagagac                                                   20


<210>  7982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7982
auuucccagc gucaucuacg                                                   20


<210>  7983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7983
cuauuuccca gcgucaucua                                                   20


<210>  7984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7984
cucuauuucc cagcgucauc                                                   20


<210>  7985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7985
cucucuauuu cccagcguca                                                   20


<210>  7986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7986
uucucucucu cuauuuccca                                                   20


<210>  7987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7987
cuuucucucu cucuauuucc                                                   20


<210>  7988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7988
cucuuucucu cucucuauuu                                                   20


<210>  7989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7989
cucucuuucu cucucucuau                                                   20


<210>  7990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7990
cucucucuuu cucucucucu                                                   20


<210>  7991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7991
cucucucucu uucucucucu                                                   20


<210>  7992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7992
cucucucucu cuuucucucu                                                   20


<210>  7993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7993
cucucucucu cucuuucucu                                                   20


<210>  7994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7994
gccuuuaggg gaauggggcu                                                   20


<210>  7995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7995
ugcuguaugu aguaaauuaa                                                   20


<210>  7996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7996
uuaucccauu agcccgcugu                                                   20


<210>  7997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7997
agggcugcua uagcuaugaa                                                   20


<210>  7998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7998
auguguucug auguccauuu                                                   20


<210>  7999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  7999
aacaaugggu ucguuuauuu                                                   20


<210>  8000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8000
uaaagcccug cauauuuccc                                                   20


<210>  8001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8001
ugccuuuuaa aaguuagcag                                                   20


<210>  8002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8002
accugcuugg aaaaauguuu                                                   20


<210>  8003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8003
caaccugcuu ggaaaaaugu                                                   20


<210>  8004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8004
gccaauccca uccucauauc                                                   20


<210>  8005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8005
uaucggcaaa guucccacaa                                                   20


<210>  8006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8006
uuuuuucaga caacuuccca                                                   20


<210>  8007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8007
auugucccug ggccuggugu                                                   20


<210>  8008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8008
uuacgauucu guuacuccau                                                   20


<210>  8009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8009
guacacacau gaacaugacu                                                   20


<210>  8010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8010
uuucccccuc cguacacaca                                                   20


<210>  8011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8011
cucagucucu gugagcaaag                                                   20


<210>  8012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8012
gucucuguga gcaaaguacu                                                   20


<210>  8013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8013
gugagcaaag uacuacaagc                                                   20


<210>  8014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8014
cagagacuga gggaggaaau                                                   20


<210>  8015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8015
ugcuuguagu acuuugcuca                                                   20


<210>  8016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8016
ccugcuugua guacuuugcu                                                   20


<210>  8017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8017
ggccccaucc ucuccugcuu                                                   20


<210>  8018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8018
acuccuuuuc aggaaggccc                                                   20


<210>  8019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8019
uuuucaggaa ggcccgaaau                                                   20


<210>  8020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8020
uuuccuuauu ucuccaauug                                                   20


<210>  8021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8021
aauuggaauu auaccuaagc                                                   20


<210>  8022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8022
cgccacuucc uuucaaguuc                                                   20


<210>  8023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8023
cuucuagcau uaugauuaua                                                   20


<210>  8024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8024
acuacuucac acuuucugcc                                                   20


<210>  8025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8025
cuucuuagca accuuuguaa                                                   20


<210>  8026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8026
uuguuuagga ccuacaaaaa                                                   20


<210>  8027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8027
cuuuguuuag gaccuacaaa                                                   20


<210>  8028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8028
uuccugaacc cauuugcuau                                                   20


<210>  8029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8029
uccagugccu auauuaccuc                                                   20


<210>  8030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8030
cagauuuuaa accagaaacu                                                   20


<210>  8031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8031
aaugaagauu aaaaagaaca                                                   20


<210>  8032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8032
acauaccuga acugaugcuu                                                   20


<210>  8033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8033
aguaaguuuu uguaacaggc                                                   20


<210>  8034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8034
uaaaauccuc aaguaaguuu                                                   20


<210>  8035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8035
uuuaaaaaaa aaagaucaug                                                   20


<210>  8036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8036
aaaauuuaaa aucuuaauau                                                   20


<210>  8037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8037
uguuucuauu guucaucagc                                                   20


<210>  8038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8038
ugacuuauug acgccuucug                                                   20


<210>  8039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8039
caguaaauuu auuuaacuuu                                                   20


<210>  8040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8040
uccccauucc ccauuugauu                                                   20


<210>  8041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8041
ccauucccca uuugauuuaa                                                   20


<210>  8042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8042
uagcguaauu agguuuugca                                                   20


<210>  8043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8043
guauaugcug cucuuagcgu                                                   20


<210>  8044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8044
uagcuccuaa uaaaagagua                                                   20


<210>  8045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8045
uaauaaaaga guaauaggga                                                   20


<210>  8046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8046
uuuauuagga gcuaugagug                                                   20


<210>  8047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8047
gugugucccu auuacucuuu                                                   20


<210>  8048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8048
acccuauuaa auguccauaa                                                   20


<210>  8049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8049
agacagauag aaauaauucc                                                   20


<210>  8050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8050
aaaacugaau ccaaaaugcu                                                   20


<210>  8051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8051
agguaccgca cgcccacccc                                                   20


<210>  8052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8052
uauguaauau ucuccaacau                                                   20


<210>  8053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8053
aacauccuuu cucaguggau                                                   20


<210>  8054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8054
guggauuccu cuagccccac                                                   20


<210>  8055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8055
agccccacuc ucuccuuccc                                                   20


<210>  8056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8056
cuccuuccca cccaaacugg                                                   20


<210>  8057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8057
ccuucccacc caaacuggcu                                                   20


<210>  8058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8058
uucccaccca aacuggcuuu                                                   20


<210>  8059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8059
gauaaaaggc augacaugaa                                                   20


<210>  8060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8060
caggcacuag ggcauaagaa                                                   20


<210>  8061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8061
guucuuaugc ccuagugccu                                                   20


<210>  8062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8062
gugauaucgu gucccuguuc                                                   20


<210>  8063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8063
gaaccacaag gcaaaccacu                                                   20


<210>  8064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8064
ggaaaucagu ggcugauucc                                                   20


<210>  8065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8065
cucuuuuuuu cucccucuuu                                                   20


<210>  8066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8066
cuuuuuuucu cccucuuuuu                                                   20


<210>  8067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8067
uuuuuucucc cucuuuuuua                                                   20


<210>  8068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8068
cucuuuuuua aacaaaacaa                                                   20


<210>  8069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8069
uuuuuaaaca aaacaaaaca                                                   20


<210>  8070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8070
uaacaaaaua accccacuuu                                                   20


<210>  8071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8071
uacauggaaa ccaaagagcu                                                   20


<210>  8072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8072
uugguuucca uguaagaguc                                                   20


<210>  8073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8073
cauccuugcu uuaucuuaga                                                   20


<210>  8074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8074
uagcagaaau ccauucaaac                                                   20


<210>  8075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8075
aucucuuagc agaaauccau                                                   20


<210>  8076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8076
aacccuggac auaguuuuaa                                                   20


<210>  8077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8077
uaaaaccugu uauuuucuug                                                   20


<210>  8078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8078
guaaauuacu ugcaagaaaa                                                   20


<210>  8079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8079
uuugacacac ucuguaaauu                                                   20


<210>  8080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8080
guuuugaaca gggcacauaa                                                   20


<210>  8081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8081
cauaguaaaa gauaaaauuu                                                   20


<210>  8082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8082
uuaauaugcu uugcauauga                                                   20


<210>  8083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8083
cccaaaccgc cauuauaugg                                                   20


<210>  8084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8084
ucuguaaugu cacacuuuuu                                                   20


<210>  8085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8085
cuuuuuuuuu uuuuugaagc                                                   20


<210>  8086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8086
uuuuuuuuuu uuugaagcau                                                   20


<210>  8087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8087
uaaaagguau caauguaccu                                                   20


<210>  8088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8088
uguugauucc uaugcuaaaa                                                   20


<210>  8089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8089
ucagguugua aaaaaaaaaa                                                   20


<210>  8090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8090
auagucaagu aaauggcugg                                                   20


<210>  8091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8091
ucaaugagau uguguucaau                                                   20


<210>  8092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8092
augagauugu guucaauuuu                                                   20


<210>  8093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8093
uugaggagca uuuuuuaaaa                                                   20


<210>  8094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8094
gauaggacaa uuaagugcac                                                   20


<210>  8095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8095
accucuguau cucugauuag                                                   20


<210>  8096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8096
guaucucuga uuagagaaaa                                                   20


<210>  8097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8097
gauuagagaa aagauacaga                                                   20


<210>  8098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8098
aaucagagau acagagguug                                                   20


<210>  8099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8099
gccugugaua ucuguaucuu                                                   20


<210>  8100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8100
uccauguuaa cacaaauagc                                                   20


<210>  8101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8101
cuaaaaguug uacuucauuu                                                   20


<210>  8102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8102
uaaaauucuu ucucuucuuu                                                   20


<210>  8103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8103
ucuuuuuuua agaaugucac                                                   20


<210>  8104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8104
gucaaaccuu auugucagcc                                                   20


<210>  8105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8105
uccuuucaau augguauaca                                                   20


<210>  8106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8106
uuacuagugu auuuaauugc                                                   20


<210>  8107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8107
caccaggagc aaaguagcuu                                                   20


<210>  8108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8108
ccaggagcaa aguagcuuuu                                                   20


<210>  8109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8109
uggugagagc uuaaaagaaa                                                   20


<210>  8110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8110
caacaauggc uaccuaaaaa                                                   20


<210>  8111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8111
cccaaugcug aauuaagcua                                                   20


<210>  8112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8112
uauuuuaaaa ccaaaugaua                                                   20


<210>  8113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8113
aaaggguuaa auguaucaau                                                   20


<210>  8114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8114
uagagauuuu uuuucagugc                                                   20


<210>  8115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8115
augagcuaaa ugucugucuc                                                   20


<210>  8116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8116
auagacagaa uagauagcac                                                   20


<210>  8117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8117
ucacguuaua aaauaaaacu                                                   20


<210>  8118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8118
cguuauaaaa uaaaacugua                                                   20


<210>  8119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8119
cucucucucu uuuucucuca                                                   20


<210>  8120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8120
cucucucuuu uucucucaga                                                   20


<210>  8121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8121
cucucuuuuu cucucagaac                                                   20


<210>  8122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8122
cucuuuuucu cucagaacgg                                                   20


<210>  8123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8123
cuuuuucucu cagaacggaa                                                   20


<210>  8124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8124
uuuucucuca gaacggaacu                                                   20


<210>  8125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8125
cagaacggaa cuggaaacag                                                   20


<210>  8126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8126
gaacggaacu ggaaacagca                                                   20


<210>  8127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8127
gcaacgaauu agggacaauu                                                   20


<210>  8128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8128
ugugcaauaa uuuacauguu                                                   20


<210>  8129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8129
aaguuugcgu aaaaugcaau                                                   20


<210>  8130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8130
ccguuugaau gcaugaucug                                                   20


<210>  8131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8131
cauauucuua gcuucguuac                                                   20


<210>  8132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8132
uauucuuagc uucguuacuu                                                   20


<210>  8133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8133
cuguaggauu uuuuucuagu                                                   20


<210>  8134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8134
agccccacuc ccuguaggau                                                   20


<210>  8135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8135
ccuuccccau cgcccuccag                                                   20


<210>  8136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8136
caccugacac ccccuuuuuc                                                   20


<210>  8137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8137
cucccaccug acacccccuu                                                   20


<210>  8138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8138
cucacuccca ccugacaccc                                                   20


<210>  8139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8139
auucaguuuu uauaucauua                                                   20


<210>  8140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8140
aucacugugc cauuuuuuca                                                   20


<210>  8141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8141
aggguacugu acacgcuaaa                                                   20


<210>  8142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8142
ccaggcacau gaaaacgcau                                                   20


<210>  8143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8143
gggcacaggc auaguugcac                                                   20


<210>  8144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8144
cauuuauaag gccuuucgcc                                                   20


<210>  8145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8145
uguggacagu gagauugcua                                                   20


<210>  8146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8146
cuguccacag gagaagccac                                                   20


<210>  8147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8147
caagugucgc ugcgucugcc                                                   20


<210>  8148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8148
uuugagcugg gccugcccgg                                                   20


<210>  8149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8149
aaagagggca gacgcagcga                                                   20


<210>  8150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8150
cuccacuucc cgugccgcug                                                   20


<210>  8151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8151
acuucccgug ccgcugcgcc                                                   20


<210>  8152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8152
gggcgcagcg gcacgggaag                                                   20


<210>  8153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8153
guccagcucc ccgggcggug                                                   20


<210>  8154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8154
ccgggcggug uggagaagcg                                                   20


<210>  8155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8155
acaccgcccg gggagcugga                                                   20


<210>  8156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8156
cguucuccga ggagugcucc                                                   20


<210>  8157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8157
gaggagugcu ccgacgagga                                                   20


<210>  8158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8158
gagaacggga guuugcgcuu                                                   20


<210>  8159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8159
ucggagaacg ggaguuugcg                                                   20


<210>  8160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8160
gacgaggagg caaaaggcga                                                   20


<210>  8161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8161
ucggagcacu ccucggagaa                                                   20


<210>  8162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8162
ucgucggagc acuccucgga                                                   20


<210>  8163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8163
agacaaucgc cuuuugccuc                                                   20


<210>  8164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8164
gaagcuaagg aagggaucuu                                                   20


<210>  8165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8165
aagaucccuu ccuuagcuuc                                                   20


<210>  8166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8166
aggcagcuca aagaucccuu                                                   20


<210>  8167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8167
ccggcuacgc ggccuccagg                                                   20


<210>  8168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8168
caguggcucg ccggcuacgc                                                   20


<210>  8169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8169
guguugggca ucgcggccgg                                                   20


<210>  8170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8170
uucucgagcu ugaugcgcuu                                                   20


<210>  8171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8171
agcuugaugc gcuuagagaa                                                   20


<210>  8172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8172
agaaggaguu cgaccugccc                                                   20


<210>  8173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8173
aagcgcauca agcucgagaa                                                   20


<210>  8174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8174
gcgagcuggg gcugcccagc                                                   20


<210>  8175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8175
cugagccccu ucucuaagcg                                                   20


<210>  8176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8176
gggggccugu ccaaaaagcu                                                   20


<210>  8177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8177
cccggggagc agccgcggcc                                                   20


<210>  8178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8178
ccgggcgagu cggccucggg                                                   20


<210>  8179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8179
ccggccaccg agucuucguc                                                   20


<210>  8180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8180
guggccggcg agucggaccg                                                   20


<210>  8181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8181
gccucggcca gguggccgcg                                                   20


<210>  8182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8182
gccagguggc cgcgcuuaug                                                   20


<210>  8183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8183
cccaggaccu gguggaaggc                                                   20


<210>  8184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8184
cugaagugcu gcauggagcu                                                   20


<210>  8185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8185
augcagcacu ucagcgaggc                                                   20


<210>  8186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8186
gcuccaugca gcacuucagc                                                   20


<210>  8187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8187
cgucgcccac gcccacgacc                                                   20


<210>  8188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8188
ucgcccacgc ccacgaccgc                                                   20


<210>  8189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8189
cggggcgcgg ucgugggcgu                                                   20


<210>  8190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8190
ugguggcgcg ccgccuccag                                                   20


<210>  8191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8191
aggcucagcc cgaagccgua                                                   20


<210>  8192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8192
gcccgaagcc guaguccacc                                                   20


<210>  8193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8193
cgcucuccgu cagcuccucc                                                   20


<210>  8194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8194
cucuccguca gcuccuccuc                                                   20


<210>  8195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8195
ccgucagcuc cuccuccucc                                                   20


<210>  8196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8196
gucagcuccu ccuccuccuc                                                   20


<210>  8197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8197
uccuccuccu cuuccuccuc                                                   20


<210>  8198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8198
uccuccucuu ccuccucuuc                                                   20


<210>  8199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8199
uccucuuccu ccucuucuuc                                                   20


<210>  8200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8200
ucuuccuccu cuucuuccuc                                                   20


<210>  8201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8201
uccuccucuu cuuccucuuc                                                   20


<210>  8202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8202
ucuucuuccu cuuccucguc                                                   20


<210>  8203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8203
ucuuccucuu ccucgucguc                                                   20


<210>  8204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8204
uccucgucgu ccuccucuuc                                                   20


<210>  8205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8205
ucguccuccu cuuccuccuc                                                   20


<210>  8206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8206
ucuuccuccu cguccccguu                                                   20


<210>  8207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8207
uccuccucgu ccccguucuc                                                   20


<210>  8208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8208
ucguccccgu ucuccgggau                                                   20


<210>  8209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8209
uccccguucu ccgggaucag                                                   20


<210>  8210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8210
gggaucaggu uggggucguu                                                   20


<210>  8211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8211
cucuugaacu uggccaccac                                                   20


<210>  8212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8212
ugaacuuggc caccacggac                                                   20


<210>  8213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8213
aguccguggu ggccaaguuc                                                   20


<210>  8214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8214
ccggaacccg gcaccagcga                                                   20


<210>  8215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8215
accgccagcu ccccggaacc                                                   20


<210>  8216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8216
ccaccgccag cuccccggaa                                                   20


<210>  8217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8217
cccguguggc ugcgccggug                                                   20


<210>  8218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8218
gaaauuugaa cgucuugccg                                                   20


<210>  8219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8219
caugacuugg acuugaccgg                                                   20


<210>  8220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8220
cagcccccgg ucaaguccaa                                                   20


<210>  8221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8221
cucccagccc ccggucaagu                                                   20


<210>  8222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8222
ucccucccag cccccgguca                                                   20


<210>  8223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8223
gcaauccgcc ccuccucccu                                                   20


<210>  8224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8224
ucugcaaucc gccccuccuc                                                   20


<210>  8225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8225
cuccucugca auccgccccu                                                   20


<210>  8226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8226
cuaagucucc uagagaaauc                                                   20


<210>  8227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8227
aagucuccua gagaaaucca                                                   20


<210>  8228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8228
uagagaaauc cauggcggga                                                   20


<210>  8229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8229
aggagacuua gagagcuggc                                                   20


<210>  8230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8230
cgccauggau uucucuagga                                                   20


<210>  8231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8231
auagccauug gauucaaccg                                                   20


<210>  8232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8232
ggugaugggu ggccagggcc                                                   20


<210>  8233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8233
uccgccccca ggcgcucuau                                                   20


<210>  8234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8234
augcgguggg gguccaagug                                                   20


<210>  8235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8235
gugguggacu aaacaggggg                                                   20


<210>  8236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8236
cccccuguuu aguccaccac                                                   20


<210>  8237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8237
cucgauacug auccugguau                                                   20


<210>  8238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8238
cgauacugau ccugguauuc                                                   20


<210>  8239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8239
auacugaucc ugguauucuu                                                   20


<210>  8240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8240
augggauuca uauugcagac                                                   20


<210>  8241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8241
ccaugggauu cauauugcag                                                   20


<210>  8242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8242
uggauuaaga aucuacuuag                                                   20


<210>  8243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8243
ugcaacacgc acagaacacu                                                   20


<210>  8244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8244
ucuuuaccug caaaauaaua                                                   20


<210>  8245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8245
gugauuaaac auugauguug                                                   20


<210>  8246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8246
agccuucccu gcccccaccc                                                   20


<210>  8247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8247
accccaaggc cuaagcccuc                                                   20


<210>  8248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8248
cugaccuacc cccugugccu                                                   20


<210>  8249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8249
gacgugccag gcacaggggg                                                   20


<210>  8250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8250
guucuagaaa uuuuauaucc                                                   20


<210>  8251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8251
agccagaacu ggucaggauu                                                   20


<210>  8252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8252
acaaaugucu ucuaaacuuu                                                   20


<210>  8253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8253
ucuccaugug ccucuguuuc                                                   20


<210>  8254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8254
augugccucu guuuccuccu                                                   20


<210>  8255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8255
guuuccuccu uguuaaguga                                                   20


<210>  8256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8256
uuguuaagug agaaacuugg                                                   20


<210>  8257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8257
cuuaacaagg aggaaacaga                                                   20


<210>  8258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8258
augaaauguu ugccuauuua                                                   20


<210>  8259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8259
cuacaauguu cuauggcccu                                                   20


<210>  8260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8260
uuuuaacaau aucaacaauu                                                   20


<210>  8261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8261
cauuuuaaca auaucaacaa                                                   20


<210>  8262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8262
uaaaauacuu ccguggaaaa                                                   20


<210>  8263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8263
caccccagac ugugggagga                                                   20


<210>  8264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8264
cacagucugg ggugugagaa                                                   20


<210>  8265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8265
cugauccucc cacagucugg                                                   20


<210>  8266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8266
aagaauguuu aaaaaaucug                                                   20


<210>  8267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8267
uaaagauugg auacagccua                                                   20


<210>  8268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8268
uaacuuuucc agacuugcau                                                   20


<210>  8269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8269
uccuaacuuu uccagacuug                                                   20


<210>  8270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8270
gccugcugcc ugucauggcg                                                   20


<210>  8271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8271
uccucauugu uuugagaggc                                                   20


<210>  8272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8272
ucauuguuuu gagaggcuaa                                                   20


<210>  8273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8273
uuguuuugag aggcuaacaa                                                   20


<210>  8274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8274
aaacaaugag gaggaggaua                                                   20


<210>  8275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8275
caaaacaaug aggaggagga                                                   20


<210>  8276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8276
gcugggacuc agcuccaguu                                                   20


<210>  8277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8277
gcuccaguug agaaagaaac                                                   20


<210>  8278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8278
aguugagaaa gaaacagaaa                                                   20


<210>  8279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8279
acuggagcug agucccagcc                                                   20


<210>  8280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8280
ggccaguagc caagccgucu                                                   20


<210>  8281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8281
agacggcuug gcuacuggcc                                                   20


<210>  8282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8282
ccagacggcu uggcuacugg                                                   20


<210>  8283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8283
uggguucuuu ucagcaaggg                                                   20


<210>  8284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8284
ccaaaugaaa uauuuuguga                                                   20


<210>  8285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8285
ccauauauau uuaauuuagc                                                   20


<210>  8286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8286
uccuuuggcu accauuacuu                                                   20


<210>  8287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8287
uccucguccu uuggcuacca                                                   20


<210>  8288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8288
gggaaguuuu guuuuucuca                                                   20


<210>  8289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8289
guuauauuuu aaggcuuuuu                                                   20


<210>  8290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8290
uucuuuuaaa agaagggcug                                                   20


<210>  8291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8291
ugcagcccuu cuuuuaaaag                                                   20


<210>  8292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8292
cugguagauu uuuuuuuuuu                                                   20


<210>  8293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8293
uaaccucccu gguagauuuu                                                   20


<210>  8294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8294
cucuuaaccu cccugguaga                                                   20


<210>  8295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8295
uucucacucu uaaccucccu                                                   20


<210>  8296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8296
auuuagcaag ucagaaagaa                                                   20


<210>  8297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8297
ggagccccca aacacuggua                                                   20


<210>  8298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8298
ugagaagacc cugccggcuu                                                   20


<210>  8299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8299
cucaagcacu ugucuaaaua                                                   20


<210>  8300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8300
agcacuuguc uaaauaaugg                                                   20


<210>  8301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8301
ugcccugacc uuguaauuua                                                   20


<210>  8302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8302
auauaucuca cuccugggua                                                   20


<210>  8303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8303
cuccugggua aaucucuuaa                                                   20


<210>  8304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8304
uggguaaauc ucuuaaacaa                                                   20


<210>  8305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8305
uaaacaagau uagaugguaa                                                   20


<210>  8306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8306
ucucuucaaa gggaaauaaa                                                   20


<210>  8307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8307
cuucaaaggg aaauaaaaag                                                   20


<210>  8308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8308
ucaaagggaa auaaaaagcu                                                   20


<210>  8309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8309
augaagcuuu uuauuucccu                                                   20


<210>  8310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8310
guggcuuccu ccuuguccuc                                                   20


<210>  8311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8311
uuguccuccc uagaucucug                                                   20


<210>  8312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8312
cuagaucucu gggugacuau                                                   20


<210>  8313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8313
gggugacuau cauuccuauu                                                   20


<210>  8314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8314
gaucgucagg cuaaauagga                                                   20


<210>  8315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8315
aaaugccuua aaauuauauu                                                   20


<210>  8316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8316
uaauuagugg ugcugguuuc                                                   20


<210>  8317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8317
uuuguauccu uucaaaaagg                                                   20


<210>  8318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8318
uuuaagccuu uuugaaagga                                                   20


<210>  8319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8319
gggcagcaaa auaaaaugga                                                   20


<210>  8320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8320
gaaaaaaagu uuaggaugcu                                                   20


<210>  8321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8321
ccucucucuc auacaucagg                                                   20


<210>  8322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8322
cucucauaca ucaggucaga                                                   20


<210>  8323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8323
cucauacauc aggucagaga                                                   20


<210>  8324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8324
cauacaucag gucagagaaa                                                   20


<210>  8325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8325
uacaucaggu cagagaaaau                                                   20


<210>  8326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8326
gaccugaugu augagagaga                                                   20


<210>  8327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8327
uuauaagaua aaaugccauu                                                   20


<210>  8328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8328
ugaucuagaa uaucuaguug                                                   20


<210>  8329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8329
uugacauuau gauuacacua                                                   20


<210>  8330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8330
aucguaacag cccuucucau                                                   20


<210>  8331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8331
auguaaucuu uagucucaau                                                   20


<210>  8332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8332
ccauguaauc uuuagucuca                                                   20


<210>  8333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8333
cuccauguaa ucuuuagucu                                                   20


<210>  8334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8334
gcucaugccg guguaccaua                                                   20


<210>  8335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8335
ugccggugua ccauauuaua                                                   20


<210>  8336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8336
cagauucuaa auuccuaaac                                                   20


<210>  8337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8337
gaugaaaauc aacuucucaa                                                   20


<210>  8338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8338
auuugagagc cucauugggc                                                   20


<210>  8339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8339
aauugagaag uugauuuuca                                                   20


<210>  8340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8340
caaauugaga aguugauuuu                                                   20


<210>  8341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8341
uugggcauuu acggggauug                                                   20


<210>  8342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8342
aaaucaaaac aauccccgua                                                   20


<210>  8343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8343
aguuccuaug cuuaggggcc                                                   20


<210>  8344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8344
agauucagaa gaacaaggag                                                   20


<210>  8345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8345
uuguucuucu gaaucuugag                                                   20


<210>  8346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8346
gaccuccuug uucuucugaa                                                   20


<210>  8347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8347
agucucagac cuccuuguuc                                                   20


<210>  8348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8348
auuauccacu agauuguaac                                                   20


<210>  8349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8349
gggauaguca uuugauuucu                                                   20


<210>  8350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8350
gagucuugga auuccuaucu                                                   20


<210>  8351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8351
gagaaaucaa augacuaucc                                                   20


<210>  8352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8352
uuuuacagau aggaauucca                                                   20


<210>  8353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8353
guaaacuauc aggucgaaug                                                   20


<210>  8354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8354
cauucacauu cgaccugaua                                                   20


<210>  8355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8355
guaauuaauc accccuggua                                                   20


<210>  8356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8356
ggaagccguu cggggugugu                                                   20


<210>  8357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8357
uuuuggccug gguuaaggcc                                                   20


<210>  8358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8358
aguuaaagag caggggugac                                                   20


<210>  8359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8359
uuaacuagag ccuccuuuug                                                   20


<210>  8360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8360
gcugugugcc agucaccccu                                                   20


<210>  8361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8361
uagcacuucc cuguggccac                                                   20


<210>  8362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8362
ggaagccagg ggcagcaggu                                                   20


<210>  8363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8363
agaacaaacc ugaugcccau                                                   20


<210>  8364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8364
uaaauugguc cugccagcag                                                   20


<210>  8365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8365
cuuuguggga aggugggaga                                                   20


<210>  8366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8366
caccuuccca caaagggagg                                                   20


<210>  8367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8367
cccaccuucc cacaaaggga                                                   20


<210>  8368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8368
gacuuuccua ccagucaaau                                                   20


<210>  8369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8369
cagcccucag gaagaccagg                                                   20


<210>  8370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8370
ggaagaccag gcugaagacc                                                   20


<210>  8371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8371
gucuucagcc uggucuuccu                                                   20


<210>  8372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8372
caacuccacc cuccucugaa                                                   20


<210>  8373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8373
acuccacccu ccucugaacu                                                   20


<210>  8374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8374
acccuccucu gaacugcuca                                                   20


<210>  8375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8375
ucugaacugc ucaacucccu                                                   20


<210>  8376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8376
gaacugcuca acucccuucu                                                   20


<210>  8377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8377
acucccuucu aucccuuccc                                                   20


<210>  8378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8378
cuucuauccc uucccuccaa                                                   20


<210>  8379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8379
aaaaguggcu ccguuuccac                                                   20


<210>  8380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8380
guuuccacag ccccaugcag                                                   20


<210>  8381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8381
uguugcuggg ggcaucuggg                                                   20


<210>  8382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8382
ccuguugcug ggggcaucug                                                   20


<210>  8383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8383
ccccacccag ccagcaugca                                                   20


<210>  8384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8384
ccacccagcc agcaugcagg                                                   20


<210>  8385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8385
cgguuucuag ucccugcaug                                                   20


<210>  8386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8386
uaaaccuucu gcaaucugug                                                   20


<210>  8387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8387
cuucccccaa gcugggccua                                                   20


<210>  8388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8388
ucugcucccu ucccccaagc                                                   20


<210>  8389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8389
ggaccugagg gcuuaugaaa                                                   20


<210>  8390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8390
gguccugagg gcuggguggu                                                   20


<210>  8391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8391
uuguuaccua ggauuaccua                                                   20


<210>  8392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8392
uagguaaucc uagguaacaa                                                   20


<210>  8393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8393
gggugcaugc ccugcucuuc                                                   20


<210>  8394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8394
ucagauacca uuuacaagau                                                   20


<210>  8395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8395
cucccaucua aaaacagucc                                                   20


<210>  8396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8396
caucuaaaaa cagucccccu                                                   20


<210>  8397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8397
aagggggacu guuuuuagau                                                   20


<210>  8398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8398
ggcaucuugc ucuuuguuau                                                   20


<210>  8399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8399
uuguuauucu cucuccauga                                                   20


<210>  8400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8400
cuccaugacc uuuuuccuuu                                                   20


<210>  8401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8401
ccaugaccuu uuuccuuuuc                                                   20


<210>  8402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8402
augaccuuuu uccuuuucuu                                                   20


<210>  8403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8403
guguaggaac acaugguaug                                                   20


<210>  8404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8404
cuugaacaag uaaauggugg                                                   20


<210>  8405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8405
accaccacca uuaccaccac                                                   20


<210>  8406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8406
acuaucacca ccaccaccac                                                   20


<210>  8407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8407
aaaaccagga gaaaaauuag                                                   20


<210>  8408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8408
ugguuuuaga gaaaaaugca                                                   20


<210>  8409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8409
ggaauaaccc uaaacugacu                                                   20


<210>  8410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8410
uuuugauucu ggccuuggcu                                                   20


<210>  8411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8411
uuuaggacuu uggguauagu                                                   20


<210>  8412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8412
uguggccuca uuuaggacuu                                                   20


<210>  8413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8413
agaggcacag gcaucuucaa                                                   20


<210>  8414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8414
ggagcccauu uuauuacugg                                                   20


<210>  8415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8415
guggcuagug auugaagaug                                                   20


<210>  8416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8416
ccagggucuu gucuugcucc                                                   20


<210>  8417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8417
ucccuguggg ucuucucccc                                                   20


<210>  8418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8418
cagccuccag ugaggaaaga                                                   20


<210>  8419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8419
agugaggaaa gaaaaagggg                                                   20


<210>  8420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8420
cuggaggcug ggagcugaua                                                   20


<210>  8421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8421
ccuuuuucuu uccucacugg                                                   20


<210>  8422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8422
ggggcugagu ggagugggga                                                   20


<210>  8423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8423
gccccagagg gacuucuucc                                                   20


<210>  8424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8424
acucagcccc agagggacuu                                                   20


<210>  8425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8425
ccacuccacu cagccccaga                                                   20


<210>  8426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8426
cuuggcagcc gcuccccacu                                                   20


<210>  8427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8427
uucaguacuu aaaaaguaag                                                   20


<210>  8428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8428
ucucuauaca cauggacauu                                                   20


<210>  8429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8429
auacacaugg acauuuguag                                                   20


<210>  8430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8430
acuuacaaau acccugcggg                                                   20


<210>  8431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8431
ucccaggcgu ggggauuaga                                                   20


<210>  8432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8432
aauccccacg ccugggauga                                                   20


<210>  8433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8433
augugcagaa cgaggggagg                                                   20


<210>  8434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8434
uucugcacau ggagcucuaa                                                   20


<210>  8435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8435
ccucguucug cacauggagc                                                   20


<210>  8436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8436
uccccucguu cugcacaugg                                                   20


<210>  8437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8437
ccuccccucg uucugcacau                                                   20


<210>  8438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8438
agugcagaag uuuaucugug                                                   20


<210>  8439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8439
ucuuuuguuu caggccuugg                                                   20


<210>  8440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8440
ccacucuucu uuuguuucag                                                   20


<210>  8441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8441
gggaaauaac ucaccacucu                                                   20


<210>  8442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8442
ccuuuccuaa aacaaacccu                                                   20


<210>  8443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8443
ccccuuuccu aaaacaaacc                                                   20


<210>  8444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8444
uuuccuauca gcauuuugcu                                                   20


<210>  8445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8445
gucccauaaa aaacgauuca                                                   20


<210>  8446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8446
gucccucugc cccccucuuc                                                   20


<210>  8447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8447
gccccccucu ucccaugcua                                                   20


<210>  8448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8448
ucccaugcua uauuuaugau                                                   20


<210>  8449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8449
guccagaaau gcccagguuu                                                   20


<210>  8450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8450
agaauccugu caacuggaaa                                                   20


<210>  8451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8451
caauacaaag caauggaaga                                                   20


<210>  8452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8452
ggugaagaca agugacuucu                                                   20


<210>  8453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8453
cacuaauaaa augaaucuaa                                                   20


<210>  8454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8454
gugcuacaaa uguuucauug                                                   20


<210>  8455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8455
aaaaaaucuc agugcuacaa                                                   20


<210>  8456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8456
ucucaaaaaa aucucagugc                                                   20


<210>  8457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8457
ucuagcuaac uaaccaugua                                                   20


<210>  8458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8458
agcuaacuaa ccauguagcu                                                   20


<210>  8459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8459
agauggacag cuacaugguu                                                   20


<210>  8460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8460
agucugucuc aagauggaca                                                   20


<210>  8461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8461
ugcaccaucu auccuccagu                                                   20


<210>  8462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8462
guguguucua gagguuugga                                                   20


<210>  8463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8463
agaacacaca gagcgucucc                                                   20


<210>  8464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8464
aaaccucuag aacacacaga                                                   20


<210>  8465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8465
ccaaucauca ugaacuccaa                                                   20


<210>  8466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8466
cgcccucccc aaucaucaug                                                   20


<210>  8467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8467
uaauauuaag cuaauggaaa                                                   20


<210>  8468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8468
aggauagcag gucucaagug                                                   20


<210>  8469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8469
aguguaaaau acauccuguu                                                   20


<210>  8470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8470
uuauauagag cacacugcca                                                   20


<210>  8471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8471
auauaaggag aacaggaugu                                                   20


<210>  8472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8472
uugcgaaagg aaaucuuguc                                                   20


<210>  8473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8473
gcagcacacc aucguuaccc                                                   20


<210>  8474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8474
uacacagaca gcauaggucu                                                   20


<210>  8475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8475
gcaggccugg uaacagcaga                                                   20


<210>  8476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8476
ggcuaggugg ugcuuccacc                                                   20


<210>  8477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8477
guagauguuc ucaggcuagg                                                   20


<210>  8478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8478
cugacccaaa acaaaauaaa                                                   20


<210>  8479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8479
gacccaaaac aaaauaaaca                                                   20


<210>  8480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8480
auucacuuga cguaaacagu                                                   20


<210>  8481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8481
caauucacuu gacguaaaca                                                   20


<210>  8482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8482
uugaaaaaua ccaugacaaa                                                   20


<210>  8483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8483
gauuucucau ugaaaaauac                                                   20


<210>  8484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8484
gccguucacu aaguuugcug                                                   20


<210>  8485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8485
gugaucccag cauaaacgca                                                   20


<210>  8486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8486
ccauacaagg auccaaguac                                                   20


<210>  8487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8487
gccacuuacu cugggaagag                                                   20


<210>  8488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8488
gggaagagac ccugaagugc                                                   20


<210>  8489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8489
ucccagagua aguggcagag                                                   20


<210>  8490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8490
agcaagaaau gggagaacug                                                   20


<210>  8491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8491
cauuucuugc uggaggccug                                                   20


<210>  8492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8492
caugaaucuc uuguuggcaa                                                   20


<210>  8493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8493
uguuggcaaa cuugucuaca                                                   20


<210>  8494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8494
acagugucug gccguguggc                                                   20


<210>  8495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8495
cuuugccaca cggccagaca                                                   20


<210>  8496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8496
ucugacuauc uggcagcaua                                                   20


<210>  8497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8497
guuuccccau cuguaaaaug                                                   20


<210>  8498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8498
uggccucagu uuccccaucu                                                   20


<210>  8499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8499
ugacuccuga uccagugguc                                                   20


<210>  8500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8500
ugauccagug gucuuuccug                                                   20


<210>  8501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8501
uccccccugc ugcuccugcc                                                   20


<210>  8502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8502
ugccgugguc uucacugccc                                                   20


<210>  8503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8503
cccaagacgg uuaaguacug                                                   20


<210>  8504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8504
caauuggaaa acaaggccug                                                   20


<210>  8505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8505
gcugccuggg ccuccuggcc                                                   20


<210>  8506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8506
uggccucacc uuugcugugu                                                   20


<210>  8507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8507
ccuuugcugu guucacccuc                                                   20


<210>  8508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8508
accucugcuu ccccugcaga                                                   20


<210>  8509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8509
gcuuccccug cagaauuaga                                                   20


<210>  8510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8510
caaagacagu gugcuuuuuu                                                   20


<210>  8511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8511
cccuugcauu uaucuuccuu                                                   20


<210>  8512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8512
uccugaagga agauaaaugc                                                   20


<210>  8513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8513
uugguaagua aaaucgacau                                                   20


<210>  8514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8514
cuagggcuua acuucuugcu                                                   20


<210>  8515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8515
gaagcauuaa uugugauacu                                                   20


<210>  8516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8516
aggagcagcu cugccuuccc                                                   20


<210>  8517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8517
aguuugacgc ucagaagcau                                                   20


<210>  8518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8518
ucgaguuuga cgcucagaag                                                   20


<210>  8519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8519
gccuucccag gccaaggugg                                                   20


<210>  8520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8520
uuuuccccac cuuggccugg                                                   20


<210>  8521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8521
accaggggca gcuccuuuuc                                                   20


<210>  8522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8522
ucuuuuccca ccuucgcuuu                                                   20


<210>  8523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8523
ccagccagag augggcucug                                                   20


<210>  8524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8524
ggcuggggag aaugaaagcg                                                   20


<210>  8525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8525
gguugcuggc uaggaagugg                                                   20


<210>  8526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8526
uuuuuucuuu guuagugcuc                                                   20


<210>  8527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8527
uaggcaagug auucucacag                                                   20


<210>  8528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8528
cagcgcagac ccaggcccac                                                   20


<210>  8529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8529
caggugaugc ugaucggggg                                                   20


<210>  8530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8530
gacuuacuga aucagaaauu                                                   20


<210>  8531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8531
auuucugauu caguaagucu                                                   20


<210>  8532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8532
aggugauucu caugcacacu                                                   20


<210>  8533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8533
ugcacacuca agcugaauca                                                   20


<210>  8534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8534
agcugaauca gcacugcugu                                                   20


<210>  8535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8535
gcccagggaa uuucaaagcu                                                   20


<210>  8536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8536
uggcccaugg gucucugccc                                                   20


<210>  8537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8537
uguccaggac ccaccuccuu                                                   20


<210>  8538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8538
uuuaggacug gaacagucaa                                                   20


<210>  8539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8539
auuaggaaau ucagguucca                                                   20


<210>  8540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8540
gucugucauu gauaaggaca                                                   20


<210>  8541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8541
ccaucagguc cagggccuuc                                                   20


<210>  8542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8542
aucaggucca gggccuucuu                                                   20


<210>  8543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8543
ugcuaagaag gcccuggacc                                                   20


<210>  8544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8544
cugcuuccau uaaagccgac                                                   20


<210>  8545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8545
uguuucccuu ucuggucucu                                                   20


<210>  8546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8546
caaaugggac acauuucccu                                                   20


<210>  8547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8547
aaugggacac auuucccuuu                                                   20


<210>  8548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8548
aucuuuuuuc aaaugucuua                                                   20


<210>  8549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8549
cuagacccag uauuuccacu                                                   20


<210>  8550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8550
agacccagua uuuccacuug                                                   20


<210>  8551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8551
gaaaugccuu acacauuauu                                                   20


<210>  8552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8552
uauuuuucag guuucauuaa                                                   20


<210>  8553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8553
uugucaaaag uugguaccca                                                   20


<210>  8554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8554
aagcccagug ggauguuccu                                                   20


<210>  8555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8555
agaacaucuc aaagauuccu                                                   20


<210>  8556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8556
aagauuccuu gacuauuaac                                                   20


<210>  8557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8557
caaagcaguc auuaaacgug                                                   20


<210>  8558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8558
ccacaggagu acauagaugu                                                   20


<210>  8559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8559
acaggaguac auagaugugu                                                   20


<210>  8560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8560
uguggagagu ccugugguuu                                                   20


<210>  8561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8561
caaacacaua ugcaugcaca                                                   20


<210>  8562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8562
cauauacaca cacaugaaca                                                   20


<210>  8563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8563
cugaaaaaaa aaaaaaaaca                                                   20


<210>  8564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8564
acugcuuuug ugccugucuc                                                   20


<210>  8565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8565
ugacacugug acccccuuuc                                                   20


<210>  8566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8566
uuuugaagac ccagggugaa                                                   20


<210>  8567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8567
ucauaguguc auccauucuc                                                   20


<210>  8568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8568
ucaucauagu gucauccauu                                                   20


<210>  8569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8569
auauugguga caggccaaaa                                                   20


<210>  8570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8570
agucccucag cucuuccaug                                                   20


<210>  8571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8571
gcucuuccau guaccaccuu                                                   20


<210>  8572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8572
uccauguacc accuucuaga                                                   20


<210>  8573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8573
gacuagcugc acuguuguua                                                   20


<210>  8574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8574
agcucagacu agcugcacug                                                   20


<210>  8575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8575
ugacccuaug uuuaccauag                                                   20


<210>  8576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8576
cuuagauucu cugacuuauc                                                   20


<210>  8577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8577
gacuuaucag aguauuauag                                                   20


<210>  8578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8578
gauaagucag agaaucuaag                                                   20


<210>  8579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8579
auaauacucu gauaagucag                                                   20


<210>  8580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8580
agucacaggc auagcuaaug                                                   20


<210>  8581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8581
cagacuucuu aauuaaccuu                                                   20


<210>  8582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8582
cuuuuguucu agaaaugagc                                                   20


<210>  8583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8583
uuuguucuag aaaugagcau                                                   20


<210>  8584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8584
uuucuagaac aaaagagagu                                                   20


<210>  8585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8585
cucauggucc uuagauuccu                                                   20


<210>  8586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8586
caugguccuu agauuccuug                                                   20


<210>  8587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8587
ugguccuuag auuccuugau                                                   20


<210>  8588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8588
uuuuaaaacu cuuuuuugau                                                   20


<210>  8589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8589
uuuuugauca augcuauccu                                                   20


<210>  8590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8590
uagagccuug auuacucaaa                                                   20


<210>  8591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8591
aagaggauag cauugaucaa                                                   20


<210>  8592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8592
aacaacaggu uacuaacuuc                                                   20


<210>  8593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8593
uaaaagguga aguuaguaac                                                   20


<210>  8594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8594
uccuaggcuu uuucucaaua                                                   20


<210>  8595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8595
uaggcuuuuu cucaauaaag                                                   20


<210>  8596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8596
auaaagggag gaaguagaga                                                   20


<210>  8597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8597
cuuuauugag aaaaagccua                                                   20


<210>  8598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8598
acuuccuccc uuuauugaga                                                   20


<210>  8599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8599
aauaauauuc uuuggcucug                                                   20


<210>  8600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8600
gggcccaaag uauuuucacu                                                   20


<210>  8601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8601
uagauaaguu ccgccauucu                                                   20


<210>  8602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8602
gucuccuaga uaaguuccgc                                                   20


<210>  8603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8603
cagucuccua gauaaguucc                                                   20


<210>  8604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8604
cuaugcaaaa uguguguucc                                                   20


<210>  8605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8605
caugcauuca uucaaccucu                                                   20


<210>  8606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8606
ugcauucauu caaccucuca                                                   20


<210>  8607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8607
caugcauuca uucaacaaau                                                   20


<210>  8608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8608
ugcauucauu caacaaauau                                                   20


<210>  8609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8609
guaaauauuu guugaaugaa                                                   20


<210>  8610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8610
cacagcaggc uucauuuagu                                                   20


<210>  8611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8611
acccccaugu agaaagugug                                                   20


<210>  8612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8612
ugacacacuu ucuacauggg                                                   20


<210>  8613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8613
caugacacac uuucuacaug                                                   20


<210>  8614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8614
cucaugacac acuuucuaca                                                   20


<210>  8615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8615
ucuguaccuc ucucaugaca                                                   20


<210>  8616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8616
uccuuugaau uuccauagca                                                   20


<210>  8617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8617
cuuccaaaug gaaauaauuu                                                   20


<210>  8618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8618
cucccuucca aauggaaaua                                                   20


<210>  8619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8619
cccucccuuc caaauggaaa                                                   20


<210>  8620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8620
cucccucccu uccaaaugga                                                   20


<210>  8621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8621
uucccaaagc cucucucccu                                                   20


<210>  8622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8622
uaaguuuucc ucuuucccaa                                                   20


<210>  8623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8623
agguuuaacu cauaaguuuu                                                   20


<210>  8624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8624
ccagguuuaa cucauaaguu                                                   20


<210>  8625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8625
uggcucucca gguuuaacuc                                                   20


<210>  8626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8626
aagcaucuuu accugcuuuu                                                   20


<210>  8627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8627
cuaagcaucu uuaccugcuu                                                   20


<210>  8628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8628
gugcccaccu ugggcuuugc                                                   20


<210>  8629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8629
gcugucaacu ggaugaauca                                                   20


<210>  8630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8630
gaagauuucu gugacaucuu                                                   20


<210>  8631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8631
ugugaaacuc caugaagguu                                                   20


<210>  8632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8632
augaagguuc aucuguucug                                                   20


<210>  8633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8633
auuguuucuu cccccaauga                                                   20


<210>  8634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8634
gagucagaca aacaaguguu                                                   20


<210>  8635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8635
gaggaauaaa acauaguaaa                                                   20


<210>  8636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8636
cuggcuuaaa uaaucuauuu                                                   20


<210>  8637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8637
uugccaguuu aagaugggcu                                                   20


<210>  8638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8638
auguuucuug cacagucauu                                                   20


<210>  8639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8639
ucaaucauca acuugaccau                                                   20


<210>  8640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8640
aaauuucccc ucuuucuucu                                                   20


<210>  8641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8641
uucuucuuuu caaagccaug                                                   20


<210>  8642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8642
ccauggcuuu gaaaagaaga                                                   20


<210>  8643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8643
ugcucugagu ccucagcuga                                                   20


<210>  8644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8644
gaguccucag cugaggaucu                                                   20


<210>  8645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8645
gagcaggagu aagggcaccc                                                   20


<210>  8646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8646
gcugaggauc uuguuugugu                                                   20


<210>  8647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8647
gcugaggacu cagagcagga                                                   20


<210>  8648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8648
cccugccccc acuacacaca                                                   20


<210>  8649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8649
auccgaggua uuuaucaggu                                                   20


<210>  8650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8650
gauagaggca aggcuacacc                                                   20


<210>  8651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8651
caaauaaccu gauaaauacc                                                   20


<210>  8652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8652
gaaaguagcu cccaaauaac                                                   20


<210>  8653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8653
auguauuccc acugccacca                                                   20


<210>  8654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8654
ccggauucuu uucuuccuuu                                                   20


<210>  8655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8655
ggagagacug cuagaggaaa                                                   20


<210>  8656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8656
agaggaacaa gucccugcuu                                                   20


<210>  8657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8657
ccagaggaac aagucccugc                                                   20


<210>  8658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8658
agcagucucu ccagaggaac                                                   20


<210>  8659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8659
gccacucacc agcuguuucg                                                   20


<210>  8660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8660
ccagcuguuu cgugacuuug                                                   20


<210>  8661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8661
uuuuaaagau ggaaacacuu                                                   20


<210>  8662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8662
cuccugccuc ccaugcaagu                                                   20


<210>  8663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8663
ccugccuccc augcaagucc                                                   20


<210>  8664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8664
ugccucccau gcaaguccag                                                   20


<210>  8665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8665
caugcaaguc caggccuccu                                                   20


<210>  8666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8666
uuuggaccaa ccaagagacc                                                   20


<210>  8667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8667
ugguuggucc aaaggaggcc                                                   20


<210>  8668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8668
ugaccuugac cuggaugagg                                                   20


<210>  8669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8669
uccaggucaa ggucaugagg                                                   20


<210>  8670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8670
ucauccaggu caaggucaug                                                   20


<210>  8671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8671
uauaaggccc uccucaucca                                                   20


<210>  8672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8672
ccuauaaggc ccuccucauc                                                   20


<210>  8673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8673
aagccuaagg auuagccugg                                                   20


<210>  8674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8674
cuaagccuaa ggauuagccu                                                   20


<210>  8675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8675
cucucuaagc cuaaggauua                                                   20


<210>  8676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8676
ugggacacag ucuugcaaag                                                   20


<210>  8677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8677
gacauguaaa cuuugcaaga                                                   20


<210>  8678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8678
uugaagcuca gacauguaaa                                                   20


<210>  8679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8679
ggacacaccu agguuuccuc                                                   20


<210>  8680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8680
uuggcucagg acacaccuag                                                   20


<210>  8681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8681
gaccuucagu cucauuggcu                                                   20


<210>  8682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8682
guggcucaug ccagaagucc                                                   20


<210>  8683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8683
ugccagaagu ccaguagcaa                                                   20


<210>  8684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8684
gccucaugcc agagccuggc                                                   20


<210>  8685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8685
ugccagagcc uggcacccau                                                   20


<210>  8686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8686
ggcaugaggc cgagcuuugc                                                   20


<210>  8687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8687
caaaggcaca cacaggacuc                                                   20


<210>  8688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8688
aagaaaaggg aguccucucc                                                   20


<210>  8689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8689
cuuuucuuag aguccugugu                                                   20


<210>  8690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8690
ccccagccac cacaaaccag                                                   20


<210>  8691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8691
ccagccacca caaaccagga                                                   20


<210>  8692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8692
caccacaccc caucagcaug                                                   20


<210>  8693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8693
augcugaugg gguguggugg                                                   20


<210>  8694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8694
gaaauuaugu ugguuagcaa                                                   20


<210>  8695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8695
uugaaaauug gcagggcuuc                                                   20


<210>  8696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8696
cugucaagua guuaaugauc                                                   20


<210>  8697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8697
gucaaguagu uaaugaucug                                                   20


<210>  8698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8698
cccacugaau uuaaaguguu                                                   20


<210>  8699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8699
cuauuuaaag aaacccugug                                                   20


<210>  8700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8700
cuaauuuauc aguuuccauu                                                   20


<210>  8701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8701
aauuuaucag uuuccauuaa                                                   20


<210>  8702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8702
uuaauggaaa cugauaaauu                                                   20


<210>  8703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8703
acugcaaucc augccuuugu                                                   20


<210>  8704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8704
cugccccacu cgagaaauga                                                   20


<210>  8705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8705
agaaaugaag aaaaggaugg                                                   20


<210>  8706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8706
aguggggcag ggaggcaucg                                                   20


<210>  8707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8707
cagguuaagu auuagauacc                                                   20


<210>  8708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8708
gguaucuaau acuuaaccug                                                   20


<210>  8709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8709
guugaaaaug cguauuucac                                                   20


<210>  8710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8710
uccugaaugc ucaguugaaa                                                   20


<210>  8711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8711
ucgcauccau cuucacagcc                                                   20


<210>  8712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8712
ggcagguguu aucagaauca                                                   20


<210>  8713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8713
gcucuggcag guguuaucag                                                   20


<210>  8714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8714
caaauuacuc ugaagaccac                                                   20


<210>  8715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8715
gaagaccacc ccaagccuuu                                                   20


<210>  8716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8716
caacaaaugu gcuuuaugcc                                                   20


<210>  8717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8717
auauuaucau uucgaucggu                                                   20


<210>  8718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8718
agaccgaucg aaaugauaau                                                   20


<210>  8719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8719
acccauguuu gguuuucuuu                                                   20


<210>  8720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8720
ccuugccccu ccacccaugu                                                   20


<210>  8721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8721
uaaugcuauc ccuccccuug                                                   20


<210>  8722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8722
aaguucuggg auacaugugc                                                   20


<210>  8723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8723
uggaaacacc auguuugauu                                                   20


<210>  8724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8724
ugauguuuug uucgugggca                                                   20


<210>  8725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8725
cagcaccacu gccccuguuu                                                   20


<210>  8726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8726
cacagcacca cugccccugu                                                   20


<210>  8727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8727
cuugucucuc acagcaccac                                                   20


<210>  8728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8728
ccacucccuu gucucucaca                                                   20


<210>  8729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8729
accuggccgg gcugcagugu                                                   20


<210>  8730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8730
gugcacagac cagucuugga                                                   20


<210>  8731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8731
gucaggccuc ccccaaggcc                                                   20


<210>  8732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8732
cccaaggcca acaagcccag                                                   20


<210>  8733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8733
gggcuuguug gccuuggggg                                                   20


<210>  8734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8734
ucugggcuug uuggccuugg                                                   20


<210>  8735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8735
aacucuagcc cuucuuaagg                                                   20


<210>  8736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8736
agcccuucuu aaggaagcac                                                   20


<210>  8737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8737
auuaaaaaaa aaaaaaaaaa                                                   20


<210>  8738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8738
cucuguugcc caggcuggag                                                   20


<210>  8739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8739
guugcccagg cuggagugca                                                   20


<210>  8740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8740
agccugggca acagagugag                                                   20


<210>  8741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8741
cugcaaccuc cgccucccga                                                   20


<210>  8742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8742
gccucccgag uucaagcagu                                                   20


<210>  8743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8743
cgaguucaag caguccuccu                                                   20


<210>  8744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8744
ggaggcggag guugcaguga                                                   20


<210>  8745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8745
ugccucagcu cucaaguagc                                                   20


<210>  8746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8746
gcucucaagu agcuaggacu                                                   20


<210>  8747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8747
caaguagcua ggacuacagg                                                   20


<210>  8748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8748
aguagcuagg acuacaggca                                                   20


<210>  8749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8749
acaaaaaaua caaaaauuag                                                   20


<210>  8750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8750
ccauguugcc caggcugggu                                                   20


<210>  8751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8751
ccucacaucc ugccccaaca                                                   20


<210>  8752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8752
ucacauccug ccccaacagu                                                   20


<210>  8753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8753
cauccugccc caacagucgc                                                   20


<210>  8754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8754
uuccacaggg cgacuguugg                                                   20


<210>  8755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8755
ccucccagug aggaacucga                                                   20


<210>  8756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8756
cagugaggaa cucgaagauc                                                   20


<210>  8757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8757
cugggaggug aggcuaauac                                                   20


<210>  8758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8758
aagaucucag aaguguccug                                                   20


<210>  8759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8759
gaaguguccu gcuguggaca                                                   20


<210>  8760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8760
cuguccacag caggacacuu                                                   20


<210>  8761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8761
cacugccacc ucagggccgc                                                   20


<210>  8762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8762
gggccgcggc agaaaccugu                                                   20


<210>  8763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8763
ucacuugccu uucuggcacu                                                   20


<210>  8764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8764
cuugccuuuc uggcacuauu                                                   20


<210>  8765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8765
auagugccag aaaggcaagu                                                   20


<210>  8766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8766
gugacagucu uggccaagag                                                   20


<210>  8767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8767
uggccaagac ugucacagag                                                   20


<210>  8768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8768
gaaucucuug gccaagacug                                                   20


<210>  8769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8769
agaauuaaaa ccuauuaugu                                                   20


<210>  8770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8770
guguuaacca uaggacauaa                                                   20


<210>  8771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8771
gaaauuauga gaacuaauuu                                                   20


<210>  8772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8772
uaauuucuga gcagcucugu                                                   20


<210>  8773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8773
accaaaaaaa auggucuagc                                                   20


<210>  8774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8774
aacauuucuu caggaauaaa                                                   20


<210>  8775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8775
cgccugaggu gaggcugaau                                                   20


<210>  8776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8776
ccugagguga ggcugaauga                                                   20


<210>  8777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8777
ggcgagaggg cagccuaguu                                                   20


<210>  8778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8778
ccucaggcga gagggcagcc                                                   20


<210>  8779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8779
uucauucagc cucaccucag                                                   20


<210>  8780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8780
ggugcugcga ggccaggccu                                                   20


<210>  8781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8781
cagcaccaga gcgcuccuuc                                                   20


<210>  8782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8782
ucccaugacg gcaaguccuu                                                   20


<210>  8783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8783
caugacggca aguccuucuu                                                   20


<210>  8784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8784
gcccggggca ugcugcagcu                                                   20


<210>  8785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8785
gcagugccuc agcaccuucc                                                   20


<210>  8786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8786
gcaccuuccc gccucccagg                                                   20


<210>  8787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8787
caggcacaca gcagcccagc                                                   20


<210>  8788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8788
guccucaucu cucuggcaaa                                                   20


<210>  8789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8789
ucucucuggc aaagucccac                                                   20


<210>  8790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8790
cuggcaaagu cccacagaac                                                   20


<210>  8791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8791
ggcaaagucc cacagaacaa                                                   20


<210>  8792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8792
ucccuggcuu uuuacccaau                                                   20


<210>  8793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8793
cuggcuuuuu acccaauuuc                                                   20


<210>  8794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8794
uuccagauug gucaguggua                                                   20


<210>  8795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8795
gggaacucuu uccagauugg                                                   20


<210>  8796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8796
aauuugcuca gggaacucuu                                                   20


<210>  8797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8797
aaugauggca gguuguaucu                                                   20


<210>  8798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8798
guccagccau gggguguggc                                                   20


<210>  8799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8799
acuaauucug cugauuccau                                                   20


<210>  8800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8800
uauggaauca gcagaauuag                                                   20


<210>  8801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8801
aagcuccucc aaccaacagc                                                   20


<210>  8802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8802
uccaaccaac agcacaacau                                                   20


<210>  8803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8803
aaccaacagc acaacaucuu                                                   20


<210>  8804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8804
uuucuaccca ccuagcaggu                                                   20


<210>  8805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8805
gccuauggac accuggccuc                                                   20


<210>  8806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8806
gcgggcacag cggccacaca                                                   20


<210>  8807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8807
gggucccacc guggugugug                                                   20


<210>  8808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8808
aaacaaaaaa uggucuccgg                                                   20


<210>  8809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8809
cuaagacugc uugggaaaug                                                   20


<210>  8810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8810
aagacugcuu gggaaaugag                                                   20


<210>  8811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8811
uuucccaagc agucuuagag                                                   20


<210>  8812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8812
caggucuagc auuuccacgc                                                   20


<210>  8813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8813
ggucuagcau uuccacgcag                                                   20


<210>  8814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8814
ugguugggac ugcguggaaa                                                   20


<210>  8815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8815
ggucagccuc augguuggga                                                   20


<210>  8816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8816
cucaggucua cuaggaacag                                                   20


<210>  8817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8817
caggucuacu aggaacagga                                                   20


<210>  8818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8818
ggucuacuag gaacaggaaa                                                   20


<210>  8819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8819
cccuuaacaa gccccucagg                                                   20


<210>  8820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8820
cuuaacaagc cccucaggcu                                                   20


<210>  8821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8821
ggcugaaauc cuuuugcuuc                                                   20


<210>  8822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8822
accuucuacu gcuggguaga                                                   20


<210>  8823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8823
gucaccggcc cacagaucuc                                                   20


<210>  8824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8824
gcugccaucg cacucaaacc                                                   20


<210>  8825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8825
aacccuguca ggcgguggag                                                   20


<210>  8826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8826
accgccugac aggguuugag                                                   20


<210>  8827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8827
ccaccgccug acaggguuug                                                   20


<210>  8828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8828
uugaaaccgc gucagccugc                                                   20


<210>  8829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8829
ugccccagcu cuaaugcaau                                                   20


<210>  8830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8830
aaugcaauaa aaugucuuuu                                                   20


<210>  8831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8831
uugccuugaa uuacauugau                                                   20


<210>  8832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8832
uuaaaauggu gacagacccu                                                   20


<210>  8833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8833
ggcucaaacc uggcauguaa                                                   20


<210>  8834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8834
aaccuggcau guaagguauc                                                   20


<210>  8835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8835
cuuccaccaa ccguuuuuug                                                   20


<210>  8836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8836
ccauaaauca aaaaacgguu                                                   20


<210>  8837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8837
uccccauaaa ucaaaaaacg                                                   20


<210>  8838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8838
acucagcuuu cucacucaaa                                                   20


<210>  8839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8839
gcuuucucac ucaaaagcug                                                   20


<210>  8840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8840
cucaaaagcu gcuuuuguua                                                   20


<210>  8841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8841
aaagcugcuu uuguuaaauc                                                   20


<210>  8842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8842
uggcugacuu uggcggcucc                                                   20


<210>  8843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8843
uccggugugg agcaagcugu                                                   20


<210>  8844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8844
gguguggagc aagcugugga                                                   20


<210>  8845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8845
acaccggagg agccgccaaa                                                   20


<210>  8846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8846
cggggaaguc cacagcuugc                                                   20


<210>  8847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8847
ucccggggaa guccacagcu                                                   20


<210>  8848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8848
guggggccuc cucccgggga                                                   20


<210>  8849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8849
gcaccaagga cagcgaggag                                                   20


<210>  8850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8850
cuguccuugg ugcagagugg                                                   20


<210>  8851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8851
ucgcuguccu uggugcagag                                                   20


<210>  8852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8852
acccccaccu uccccccucc                                                   20


<210>  8853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8853
uccaccccca ccuucccccc                                                   20


<210>  8854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8854
agcuccucca cccccaccuu                                                   20


<210>  8855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8855
cuucugaacc uggcucucca                                                   20


<210>  8856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8856
ucugaaccug gcucuccacu                                                   20


<210>  8857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8857
ccacuccauu ucuccuggau                                                   20


<210>  8858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8858
acuccauuuc uccuggaucc                                                   20


<210>  8859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8859
auuucuccug gauccaaguc                                                   20


<210>  8860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8860
uggauccaag ucucccugua                                                   20


<210>  8861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8861
cuguaaucag cauguaucua                                                   20


<210>  8862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8862
aacuaaaagu ucaaggcuuc                                                   20


<210>  8863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8863
guggucuacc ucugacuguc                                                   20


<210>  8864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8864
gacuguccag caccaugcug                                                   20


<210>  8865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8865
ucuuugccca gcauggugcu                                                   20


<210>  8866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8866
auaaauaauu aggauucaag                                                   20


<210>  8867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8867
aacaggaaga aaaguucacu                                                   20


<210>  8868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8868
ccaacaggaa gaaaaguuca                                                   20


<210>  8869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8869
auggccuggu ccuuccagcc                                                   20


<210>  8870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8870
uugguuagug aaucauuuac                                                   20


<210>  8871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8871
gggucagccu ugacccagga                                                   20


<210>  8872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8872
ugggucaagg cugacccaga                                                   20


<210>  8873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8873
ccugggucaa ggcugaccca                                                   20


<210>  8874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8874
augguuguua uggacaauca                                                   20


<210>  8875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8875
uuuaacugug uaauuacaca                                                   20


<210>  8876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8876
auuacuaguc ugggucccuu                                                   20


<210>  8877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8877
cucaauuugu uuuagcaauc                                                   20


<210>  8878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8878
caauuuguuu uagcaauccu                                                   20


<210>  8879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8879
auuuguuuua gcaauccucc                                                   20


<210>  8880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8880
acauuuuccu cuauucucau                                                   20


<210>  8881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8881
auucucaucc ccuaccugca                                                   20


<210>  8882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8882
uccccuaccu gcacccccau                                                   20


<210>  8883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8883
gucccaagag aaagaacagu                                                   20


<210>  8884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8884
ugggacagag augggggugc                                                   20


<210>  8885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8885
gcuugaauaa uccuauuuuu                                                   20


<210>  8886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8886
uaguucuaaa uaguuuuugc                                                   20


<210>  8887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8887
acuaaaaggg cuuaaaaaua                                                   20


<210>  8888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8888
caggucuagc uuccuagccu                                                   20


<210>  8889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8889
cugccucaga ugcagggaga                                                   20


<210>  8890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8890
gaugcaggga gaacaccugc                                                   20


<210>  8891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8891
cugcaucuga ggcagggagg                                                   20


<210>  8892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8892
gggaagaaag aaggcaaagc                                                   20


<210>  8893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8893
aggagauuga ggcuucccag                                                   20


<210>  8894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8894
uugagcacag cagggcuuug                                                   20


<210>  8895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8895
aucuccuuga gcacagcagg                                                   20


<210>  8896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8896
ccucccagca ccccauuccc                                                   20


<210>  8897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8897
cagcacccca uucccaaacc                                                   20


<210>  8898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8898
gcuugggaca ugcuggaagg                                                   20


<210>  8899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8899
ucuugccuuc cagcaugucc                                                   20


<210>  8900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8900
cuucuugccu uccagcaugu                                                   20


<210>  8901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8901
uugaaaacaa aaaugaagca                                                   20


<210>  8902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8902
cugucuccca cgaccuacac                                                   20


<210>  8903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8903
gucucccacg accuacacca                                                   20


<210>  8904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8904
cacgaccuac accaggcccu                                                   20


<210>  8905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8905
gcuuugcggc uuuaacgcac                                                   20


<210>  8906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8906
caggagucag agggucaccc                                                   20


<210>  8907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8907
ggagucagag ggucacccag                                                   20


<210>  8908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8908
ugagagcaug uguaugugcu                                                   20


<210>  8909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8909
gacuccugag agcaugugua                                                   20


<210>  8910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8910
uucaccugcc agcuuguggg                                                   20


<210>  8911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8911
uagccagggg ccagcgugga                                                   20


<210>  8912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8912
auuuccaugg cucgugaauu                                                   20


<210>  8913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8913
ugaauuuuuu ugucuuguuu                                                   20


<210>  8914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8914
acccccuaca ucuuucuuuu                                                   20


<210>  8915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8915
agcacauaca acucagggcu                                                   20


<210>  8916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8916
gggcuccagu guuuuaaggg                                                   20


<210>  8917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8917
aguguuuuaa gggcauuuuu                                                   20


<210>  8918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8918
cuuguggaaa aaaaaugccc                                                   20


<210>  8919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8919
caccaucaca cagaauguac                                                   20


<210>  8920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8920
cccaccauca cacagaaugu                                                   20


<210>  8921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8921
uuccaggaca cugugauggu                                                   20


<210>  8922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8922
gcaugcucuc ugggaaguga                                                   20


<210>  8923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8923
cugggaagug aauugggaaa                                                   20


<210>  8924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8924
gggaagugaa uugggaaagu                                                   20


<210>  8925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8925
acacacagac agccccaugg                                                   20


<210>  8926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8926
agcucaggaa acccaccuag                                                   20


<210>  8927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8927
ggaaacccac cuagguauag                                                   20


<210>  8928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8928
auaccuaggu ggguuuccug                                                   20


<210>  8929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8929
ggaaccucug gucuguucua                                                   20


<210>  8930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8930
ggucuguucu aguccugcug                                                   20


<210>  8931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8931
acugggaaac aucaguccaa                                                   20


<210>  8932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8932
caggaagaga ggcagaccug                                                   20


<210>  8933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8933
uccugggagu cagaagugac                                                   20


<210>  8934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8934
cuuccuggga gucagaagug                                                   20


<210>  8935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8935
aaccacccgc cccuuaacag                                                   20


<210>  8936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8936
caugauucua ucuugagagu                                                   20


<210>  8937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8937
ugauucuauc uugagaguuu                                                   20


<210>  8938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8938
agauagaauc augagagaug                                                   20


<210>  8939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8939
caagauagaa ucaugagaga                                                   20


<210>  8940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8940
aaccaaacua aacucucaag                                                   20


<210>  8941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8941
aaaacuaaac uccaaccaaa                                                   20


<210>  8942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8942
uccuccauua aaaaaaaaaa                                                   20


<210>  8943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8943
auuaaaaaaa aaaauuggag                                                   20


<210>  8944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8944
aauuuuuuuu uuuaauggag                                                   20


<210>  8945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8945
gugaacagga aacagaaaua                                                   20


<210>  8946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8946
uucuguccgc uccgugaaca                                                   20


<210>  8947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8947
acugcacacc cuccuucugu                                                   20


<210>  8948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8948
uccacugcac acccuccuuc                                                   20


<210>  8949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8949
ccacacaccu ccuccacugc                                                   20


<210>  8950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8950
uccccacaca ccuccuccac                                                   20


<210>  8951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8951
auguaucagc cuccucccca                                                   20


<210>  8952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8952
gcuccaugua ucagccuccu                                                   20


<210>  8953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8953
gcucugcucc auguaucagc                                                   20


<210>  8954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8954
aguuccggau auucucggcu                                                   20


<210>  8955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8955
cuuuucucca guuccggaua                                                   20


<210>  8956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8956
auuucucacu uuucuccagu                                                   20


<210>  8957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8957
guaugccugg ugcccaggaa                                                   20


<210>  8958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8958
auucuucuug cuuccugugg                                                   20


<210>  8959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8959
uucaucugca aaucuauaaa                                                   20


<210>  8960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8960
cguaugugaa ggagcaauuc                                                   20


<210>  8961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8961
uucacauacg cgagaagugc                                                   20


<210>  8962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8962
auaauuaagu aucacccaac                                                   20


<210>  8963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8963
aaaauucuau uuugaaggac                                                   20


<210>  8964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8964
uucugaugac auuuuaaaua                                                   20


<210>  8965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8965
gcuaucaauu auugcugcaa                                                   20


<210>  8966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8966
gccaaucaau gaucuuccag                                                   20


<210>  8967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8967
aaaucugauu uacugauaaa                                                   20


<210>  8968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8968
caaaguaauc augggcugaa                                                   20


<210>  8969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8969
aacaucucgc aaaguaauca                                                   20


<210>  8970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8970
aacuacccac acuauccuug                                                   20


<210>  8971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8971
uccaacuacc cacacuaucc                                                   20


<210>  8972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8972
ccuguguuga uucuccucca                                                   20


<210>  8973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8973
cgccuguguu gauucuccuc                                                   20


<210>  8974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8974
uuaaugcuac acuuccugaa                                                   20


<210>  8975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8975
aauauauauc ccgugguaga                                                   20


<210>  8976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8976
accacgggau auauauuaga                                                   20


<210>  8977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8977
auucaggccu uugaaaagug                                                   20


<210>  8978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8978
aauugggacu caaauucccc                                                   20


<210>  8979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8979
aauuccccug cccagugcaa                                                   20


<210>  8980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8980
agucuucuga ccuuggccag                                                   20


<210>  8981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8981
ggcaaguccc cagguauagc                                                   20


<210>  8982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8982
guccaaggca gaacccaaau                                                   20


<210>  8983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8983
gacccugugg aaugcugcag                                                   20


<210>  8984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8984
agagaggaug cucgucccca                                                   20


<210>  8985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8985
ugaguuauuu cugacaacug                                                   20


<210>  8986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8986
cuugaguuau uucugacaac                                                   20


<210>  8987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8987
uccccaggaa acaucaaaug                                                   20


<210>  8988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8988
uucauuugau guuuccuggg                                                   20


<210>  8989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8989
cccaaagcac uagaaggagg                                                   20


<210>  8990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8990
uucuagugcu uugggcgagu                                                   20


<210>  8991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8991
cuuuuuuucu uuccuucuuu                                                   20


<210>  8992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8992
uuuauaaugg uucaguuuca                                                   20


<210>  8993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8993
uagcuucugu uaaaaaucag                                                   20


<210>  8994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8994
uacgcgguaa gugucacaau                                                   20


<210>  8995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8995
aauuuagagc uccucuguua                                                   20


<210>  8996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8996
aaauuagagu aaagcuguuc                                                   20


<210>  8997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8997
ucuguuaauu agaaagcccu                                                   20


<210>  8998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8998
guuaauuaga aagcccucag                                                   20


<210>  8999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  8999
gauuuucugc aaaugcaggu                                                   20


<210>  9000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9000
ugcuuuugau gcuucgucug                                                   20


<210>  9001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9001
uagaagggca acccaacaac                                                   20


<210>  9002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9002
gacaguguca gaaaaugcag                                                   20


<210>  9003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9003
cauucagcug aaaauagcuc                                                   20


<210>  9004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9004
aauuccaacc cucucucccc                                                   20


<210>  9005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9005
cucccccugc cuccucucuu                                                   20


<210>  9006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9006
cccccugccu ccucucuucc                                                   20


<210>  9007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9007
cccugccucc ucucuucccc                                                   20


<210>  9008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9008
ucucuucccc uuuuccuccu                                                   20


<210>  9009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9009
cuuccccuuu uccuccuuuc                                                   20


<210>  9010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9010
uccccuuuuc cuccuuucua                                                   20


<210>  9011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9011
uuucuacuuc cuugccucuc                                                   20


<210>  9012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9012
cuuucuccaa ccucuguuuc                                                   20


<210>  9013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9013
uucuccaacc ucuguuucca                                                   20


<210>  9014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9014
aaccucuguu uccagcaucu                                                   20


<210>  9015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9015
guuuccagca ucuucuuucu                                                   20


<210>  9016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9016
ucuucucucu cuuuaguccu                                                   20


<210>  9017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9017
cucuuuaguc cucaacaacu                                                   20


<210>  9018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9018
cuuuaguccu caacaacugg                                                   20


<210>  9019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9019
uuaguccuca acaacugggg                                                   20


<210>  9020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9020
acaacugggg uccucugcug                                                   20


<210>  9021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9021
gcugucaaaa acagccacau                                                   20


<210>  9022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9022
ccccucccug ccuuuuaaau                                                   20


<210>  9023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9023
ccucccugcc uuuuaaauaa                                                   20


<210>  9024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9024
cugccuuuua aauaauauuu                                                   20


<210>  9025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9025
ccaggugcgg cugcugaccg                                                   20


<210>  9026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9026
gccucaccag gugcggcugc                                                   20


<210>  9027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9027
cguguuuuuu cuuaagagaa                                                   20


<210>  9028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9028
uaagaaaaaa cacgugagcc                                                   20


<210>  9029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9029
aaauuccccc uucucuuaag                                                   20


<210>  9030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9030
uucuuuuuuu gccccccucc                                                   20


<210>  9031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9031
uucuccuucu uuuuuugccc                                                   20


<210>  9032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9032
cuuucuccuu cuuuuuuugc                                                   20


<210>  9033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9033
agaaaaaaug cacaugggcu                                                   20


<210>  9034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9034
agugguuaac cuuuccucuc                                                   20


<210>  9035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9035
gcccaugugc auuuuuucuc                                                   20


<210>  9036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9036
aauuauggga auucucacuu                                                   20


<210>  9037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9037
cuuaggaaca ccucauuaug                                                   20


<210>  9038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9038
uuauggaaca uaugugcugg                                                   20


<210>  9039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9039
ccagaccccc agcacauaug                                                   20


<210>  9040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9040
caucucccca gacccccagc                                                   20


<210>  9041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9041
aaauuuuauc aaguucaagc                                                   20


<210>  9042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9042
guggcacuug uuuaggacuu                                                   20


<210>  9043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9043
ccaccaccac caaggcauag                                                   20


<210>  9044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9044
ggaugacugc auuuauuugc                                                   20


<210>  9045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9045
aaggccagac uuccauuaca                                                   20


<210>  9046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9046
ucccauugca uuucauaagc                                                   20


<210>  9047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9047
ccccaccuca ucccauugca                                                   20


<210>  9048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9048
caccccaccu caucccauug                                                   20


<210>  9049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9049
acccuaccug gucacugugc                                                   20


<210>  9050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9050
agcaagaaug ccaaggauag                                                   20


<210>  9051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9051
acggccaugu ugcugucauc                                                   20


<210>  9052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9052
augccuuuaa gcuaacugca                                                   20


<210>  9053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9053
caccguucug uuuuugcagu                                                   20


<210>  9054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9054
uuuauauucu accuauaagg                                                   20


<210>  9055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9055
uuuaaaaaga aaaacccucc                                                   20


<210>  9056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9056
auccaacguc acgaagcugc                                                   20


<210>  9057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9057
uaucuagguu gcugggacag                                                   20


<210>  9058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9058
ccccagaaua gcaagcguug                                                   20


<210>  9059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9059
ggacugucaa acacagucua                                                   20


<210>  9060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9060
gcccguaguu cacaaggggc                                                   20


<210>  9061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9061
acccagagaa ggcaaguguu                                                   20


<210>  9062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9062
ggguugagcu cagcccguag                                                   20


<210>  9063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9063
uggaaauaau acauugcugc                                                   20


<210>  9064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9064
uuuucaacaa gaaggcugag                                                   20


<210>  9065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9065
gccuucuugu ugaaaaugag                                                   20


<210>  9066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9066
uuccucagcc uucuuguuga                                                   20


<210>  9067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9067
aaccuucugc ucugguucuc                                                   20


<210>  9068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9068
gguucuccuc ucccccacca                                                   20


<210>  9069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9069
ucucccccac cacacguaca                                                   20


<210>  9070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9070
cccccaccac acguacaaaa                                                   20


<210>  9071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9071
cccaccacac guacaaaaaa                                                   20


<210>  9072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9072
aagccccuug uucuaucagc                                                   20


<210>  9073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9073
ugaccugcug auagaacaag                                                   20


<210>  9074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9074
acucuugacc ugcugauaga                                                   20


<210>  9075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9075
auucugaaau ggauuugacu                                                   20


<210>  9076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9076
cuaggauguc uugccuuuca                                                   20


<210>  9077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9077
uuuccagaga augacuugug                                                   20


<210>  9078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9078
ggaaaggagc caugguccac                                                   20


<210>  9079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9079
cuccuacaca ucaaagugag                                                   20


<210>  9080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9080
ccuacacauc aaagugagac                                                   20


<210>  9081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9081
uacacaucaa agugagacac                                                   20


<210>  9082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9082
cuuugaugug uaggagagag                                                   20


<210>  9083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9083
acuggcccac cuugccccac                                                   20


<210>  9084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9084
aauuuggcaa cuuugccucc                                                   20


<210>  9085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9085
uucucacaca augagaaaga                                                   20


<210>  9086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9086
cacaaugaga aagaacggau                                                   20


<210>  9087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9087
uugugugaga aggaggcaaa                                                   20


<210>  9088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9088
uagaauuugg cuauccguuc                                                   20


<210>  9089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9089
cuucaguacu uaacuacaca                                                   20


<210>  9090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9090
aaaugugugu gugugugccu                                                   20


<210>  9091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9091
caaaaugugu gugugugugc                                                   20


<210>  9092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9092
uguccaucac agggcugugg                                                   20


<210>  9093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9093
ggcuuugaga ugaauaaugc                                                   20


<210>  9094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9094
aagccagagg aucucauguc                                                   20


<210>  9095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9095
uuucugugca uuauucaucu                                                   20


<210>  9096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9096
acaucaggau ugggccugaa                                                   20


<210>  9097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9097
caggaaggcc uugauagcau                                                   20


<210>  9098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9098
ggaaggccuu gauagcauua                                                   20


<210>  9099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9099
gucaaccauc uaaugcuauc                                                   20


<210>  9100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9100
gucacacugu aauaccucug                                                   20


<210>  9101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9101
gacucuguca cacuguaaua                                                   20


<210>  9102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9102
gacugugggc ucagacucug                                                   20


<210>  9103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9103
cugggaaggg auguggucau                                                   20


<210>  9104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9104
acacccuggg aagacuacug                                                   20


<210>  9105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9105
gucucucaaa ccuggccaug                                                   20


<210>  9106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9106
caaaccuggc cauggcucag                                                   20


<210>  9107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9107
aaccuggcca uggcucagcc                                                   20


<210>  9108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9108
gcccacgccc uuucauguau                                                   20


<210>  9109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9109
ggagauucaa agcgaaggca                                                   20


<210>  9110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9110
cgagucuuuu uuauucugau                                                   20


<210>  9111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9111
uuuaagucua acguugcuau                                                   20


<210>  9112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9112
uaaaugccug aauagcaacg                                                   20


<210>  9113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9113
cugugucuag cgcuccuaaa                                                   20


<210>  9114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9114
aaccugugau uugccacaag                                                   20


<210>  9115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9115
uucauugauu aaaggcaaaa                                                   20


<210>  9116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9116
cuaaccuaua uuuugcaagu                                                   20


<210>  9117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9117
ucaugcuaau gucagcagag                                                   20


<210>  9118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9118
gcugacauua gcaugaagag                                                   20


<210>  9119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9119
agucaggcuu ucaggugucu                                                   20


<210>  9120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9120
guguguggca uuguggggug                                                   20


<210>  9121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9121
cggugugugg cauugugggg                                                   20


<210>  9122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9122
cccugcugaa uuuucuuuuu                                                   20


<210>  9123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9123
aauguagauu aucuucccuu                                                   20


<210>  9124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9124
agaaggaucc caagggaaga                                                   20


<210>  9125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9125
ggcaaccaca ccagccuuua                                                   20


<210>  9126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9126
uuaaaggcug gugugguugc                                                   20


<210>  9127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9127
cuuauuuaug agcagcagaa                                                   20


<210>  9128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9128
uaaauaaggg agugggaaau                                                   20


<210>  9129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9129
ugcuuuuuac auucugcugc                                                   20


<210>  9130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9130
ucaaccauuc uaucuaagga                                                   20


<210>  9131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9131
ucauauauuu agaccaaauu                                                   20


<210>  9132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9132
aacuccagcu cccugauaac                                                   20


<210>  9133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9133
agcucccuga uaacaucugc                                                   20


<210>  9134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9134
cugauaacau cugccacuaa                                                   20


<210>  9135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9135
agaauggagc ccucaucuaa                                                   20


<210>  9136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9136
auucuagagu ugggaaaacc                                                   20


<210>  9137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9137
ucuaaaccug gggaagcaau                                                   20


<210>  9138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9138
cugugcuauu acuuuugacc                                                   20


<210>  9139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9139
gugcuauuac uuuugaccug                                                   20


<210>  9140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9140
uuauguagaa acauuuaaau                                                   20


<210>  9141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9141
uccaggauaa uuuaaauguu                                                   20


<210>  9142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9142
cgggcuguuc aaagaguguu                                                   20


<210>  9143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9143
uugaacagcc cgugagacaa                                                   20


<210>  9144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9144
uguuccuaga aggaaaggaa                                                   20


<210>  9145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9145
ucauguuccu agaaggaaag                                                   20


<210>  9146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9146
gguaucuuuu acaggcuuug                                                   20


<210>  9147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9147
aagaauucag acugugagag                                                   20


<210>  9148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9148
cagucugaau ucuuggagac                                                   20


<210>  9149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9149
cacagucuga auucuuggag                                                   20


<210>  9150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9150
uuggugcagu gggaauugcc                                                   20


<210>  9151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9151
cugguuccuc uccucugucc                                                   20


<210>  9152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9152
ccucuguccu uggcaaucca                                                   20


<210>  9153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9153
ucuguccuug gcaauccagu                                                   20


<210>  9154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9154
guccuuggca auccaguuac                                                   20


<210>  9155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9155
aguacuguca ucuuuaaaug                                                   20


<210>  9156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9156
gugcuacuua uacaauucac                                                   20


<210>  9157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9157
gaaacaaaaa acaaacaaac                                                   20


<210>  9158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9158
accucagaaa caaaaaacaa                                                   20


<210>  9159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9159
uguugcccgg gcuggagugc                                                   20


<210>  9160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9160
agcccgggca acaagagcga                                                   20


<210>  9161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9161
gcucaccgca aucuccgccu                                                   20


<210>  9162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9162
ccgcaaucuc cgccucccgg                                                   20


<210>  9163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9163
gccucccggg uucaagcgau                                                   20


<210>  9164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9164
cggguucaag cgauucuccu                                                   20


<210>  9165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9165
ugccucagcc ucccaaguag                                                   20


<210>  9166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9166
gccucccaag uagcugggau                                                   20


<210>  9167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9167
caaguagcug ggauuauagg                                                   20


<210>  9168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9168
accaaaaaua cagaaauuag                                                   20


<210>  9169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9169
auguugguca ggcuggucuc                                                   20


<210>  9170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9170
aacucccgac cuuaggugau                                                   20


<210>  9171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9171
cgaccuuagg ugauccaccc                                                   20


<210>  9172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9172
gccucccaaa gugcugggau                                                   20


<210>  9173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9173
caaagugcug ggauuauagg                                                   20


<210>  9174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9174
aaagcaacag uuuaauuggg                                                   20


<210>  9175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9175
cagugugaau uuaguuaggu                                                   20


<210>  9176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9176
cacaguguga auuuaguuag                                                   20


<210>  9177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9177
uuccauuucu uuuaugucau                                                   20


<210>  9178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9178
auuguaugaa uuuggauaug                                                   20


<210>  9179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9179
gcuuccuaac uaauuucugc                                                   20


<210>  9180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9180
uagaagcccu uauuucuugg                                                   20


<210>  9181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9181
ucauccagga ugacaaacag                                                   20


<210>  9182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9182
aaagaaaauu cugaguagaa                                                   20


<210>  9183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9183
gaauuuucuu uugagauagg                                                   20


<210>  9184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9184
ucuacucaga auuuucuuuu                                                   20


<210>  9185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9185
guuagaauuu caaaugucag                                                   20


<210>  9186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9186
aggacacucu gggucacuag                                                   20


<210>  9187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9187
gggucacuag caucucugcu                                                   20


<210>  9188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9188
gcuuuccuug uucccuggcu                                                   20


<210>  9189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9189
ucuccugagc ccccgggccg                                                   20


<210>  9190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9190
ugagcccccg ggccguucuc                                                   20


<210>  9191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9191
ggagaugagc cagggaacaa                                                   20


<210>  9192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9192
uuuccaacug ucuauuuacu                                                   20


<210>  9193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9193
caccccaucc aaaaauguuu                                                   20


<210>  9194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9194
ccccauccaa aaauguuuac                                                   20


<210>  9195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9195
aguucaggcu agcuuaauaa                                                   20


<210>  9196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9196
ugcuuugggg guuauuaagc                                                   20


<210>  9197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9197
uuaauagugu ccuccugcuu                                                   20


<210>  9198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9198
cuuuaauagu guccuccugc                                                   20


<210>  9199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9199
gggcauggau gguguuucau                                                   20


<210>  9200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9200
aguccaucca uguugggaua                                                   20


<210>  9201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9201
uccaguccau ccauguuggg                                                   20


<210>  9202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9202
ccuccagucc auccauguug                                                   20


<210>  9203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9203
ccaucugcaa ugggggcaaa                                                   20


<210>  9204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9204
auauuaguaa cagacccaug                                                   20


<210>  9205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9205
uacaauaucu gguuccauuc                                                   20


<210>  9206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9206
auccucuaga acauauaagu                                                   20


<210>  9207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9207
agaacauaua agucaacagg                                                   20


<210>  9208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9208
ccuguugacu uauauguucu                                                   20


<210>  9209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9209
gcaugaaggg uauaacagag                                                   20


<210>  9210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9210
guuauacccu ucaugccgag                                                   20


<210>  9211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9211
uccacccccu uugcagaguc                                                   20


<210>  9212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9212
gcaaaggggg uggaugaguu                                                   20


<210>  9213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9213
cuuaacaucc ccuagcaugc                                                   20


<210>  9214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9214
gaucagaaga caaaggcagc                                                   20


<210>  9215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9215
gugaucuaua ggauaugguc                                                   20


<210>  9216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9216
uuaagccauc auuccagagc                                                   20


<210>  9217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9217
ggaaugaugg cuuaaggagu                                                   20


<210>  9218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9218
acaauccaac uccaauuuuc                                                   20


<210>  9219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9219
aauuuucuau uccagucuua                                                   20


<210>  9220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9220
uuuccuuccu ggcuuuucuu                                                   20


<210>  9221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9221
uaccuccugg aauccugcuc                                                   20


<210>  9222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9222
uggaauccug cucauacuuc                                                   20


<210>  9223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9223
uacuucaagg ccucaaugaa                                                   20


<210>  9224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9224
augaaggucu accuagucac                                                   20


<210>  9225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9225
uccuucucca accucauaga                                                   20


<210>  9226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9226
aaccucauag aacacucauc                                                   20


<210>  9227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9227
uagaacacuc aucccaugca                                                   20


<210>  9228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9228
ucccaugcac cacucccuga                                                   20


<210>  9229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9229
cugacucaua ucuaggccuu                                                   20


<210>  9230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9230
uaucuaggcc uuacauugcu                                                   20


<210>  9231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9231
augccucuaa uuaauuucau                                                   20


<210>  9232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9232
aauuaauuuc auguguuccc                                                   20


<210>  9233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9233
uugggaacac augaaauuaa                                                   20


<210>  9234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9234
uucuccuacu ugcuucuauu                                                   20


<210>  9235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9235
uacuugcuuc uauuauauuu                                                   20


<210>  9236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9236
uuaaacagcc accccacacc                                                   20


<210>  9237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9237
aggguguggg guggcuguuu                                                   20


<210>  9238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9238
ucuccagggu gugggguggc                                                   20


<210>  9239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9239
gucagacuuu accaaccugg                                                   20


<210>  9240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9240
auagcugacu uucaaccaug                                                   20


<210>  9241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9241
gccaccugcg cauccucaau                                                   20


<210>  9242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9242
augcaaaaag cuaaguucua                                                   20


<210>  9243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9243
uuuugaugcc agagggcagc                                                   20


<210>  9244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9244
ggcaucaaaa ugagguccuu                                                   20


<210>  9245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9245
cggccaggcg cuguggcuca                                                   20


<210>  9246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9246
caccuguaau cccagcacuu                                                   20


<210>  9247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9247
caaagugcug ggauuacagg                                                   20


<210>  9248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9248
ugccccggcc ucccaaagug                                                   20


<210>  9249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9249
ggugauccuc cugccccggc                                                   20


<210>  9250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9250
ugaccucagg ugauccuccu                                                   20


<210>  9251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9251
acuaaaaaua caaaauuagc                                                   20


<210>  9252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9252
gcuacucggg aggcugaggc                                                   20


<210>  9253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9253
ggaggcugag gcaggagauc                                                   20


<210>  9254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9254
cgaguagcug agauuacagg                                                   20


<210>  9255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9255
gccucccgag uagcugagau                                                   20


<210>  9256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9256
ugccucagcc ucccgaguag                                                   20


<210>  9257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9257
cagguucaag cgaucuccug                                                   20


<210>  9258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9258
cugcaucuuc ugccucccag                                                   20


<210>  9259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9259
gcucacugca ucuucugccu                                                   20


<210>  9260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9260
uguugcccgg gcuggaaugc                                                   20


<210>  9261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9261
gucucaccaa aaaaagaaaa                                                   20


<210>  9262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9262
ccaaaaaaag aaaaaagaaa                                                   20


<210>  9263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9263
ccucaguucu ccaggcuggg                                                   20


<210>  9264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9264
guucuccagg cugggcugac                                                   20


<210>  9265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9265
aggcugggcu gacugcccac                                                   20


<210>  9266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9266
guguugagag ccaaguggcc                                                   20


<210>  9267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9267
acacggagug augaugccua                                                   20


<210>  9268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9268
caacacggag ugaugaugcc                                                   20


<210>  9269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9269
auuuccaagg uauuuagcgu                                                   20


<210>  9270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9270
caauuuccaa gguauuuagc                                                   20


<210>  9271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9271
agauucccuc ucaauuucca                                                   20


<210>  9272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9272
ccagauuccc ucucaauuuc                                                   20


<210>  9273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9273
cuuuacagga auucagcaca                                                   20


<210>  9274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9274
ugugcugaau uccuguaaag                                                   20


<210>  9275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9275
gcuuaaggag aagacauacu                                                   20


<210>  9276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9276
uuaagcggag augcuaacaa                                                   20


<210>  9277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9277
gucuuauuca ucaguauguc                                                   20


<210>  9278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9278
cgccuguaau cccagcacuu                                                   20


<210>  9279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9279
ccuguaaucc cagcacuuug                                                   20


<210>  9280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9280
caaagugcug ggauuacagg                                                   20


<210>  9281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9281
ugccuugacc ucccaaagug                                                   20


<210>  9282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9282
agugauccuc cugccuugac                                                   20


<210>  9283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9283
ugggcuccag ugauccuccu                                                   20


<210>  9284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9284
cuguugccca ggcuggucuu                                                   20


<210>  9285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9285
aucucuacaa aauuagccag                                                   20


<210>  9286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9286
acaaaauuag ccaggcaugg                                                   20


<210>  9287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9287
ggaggcugag gugacaggau                                                   20


<210>  9288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9288
ugaguagcug ggacgacagg                                                   20


<210>  9289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9289
gccuccugag uagcugggac                                                   20


<210>  9290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9290
agccauccug ucaccucagc                                                   20


<210>  9291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9291
uaggcucaag ccauccuguc                                                   20


<210>  9292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9292
cugcagccuu gaucuccuag                                                   20


<210>  9293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9293
agccuaggca acacagcgag                                                   20


<210>  9294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9294
cuguguugcc uaggcuagag                                                   20


<210>  9295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9295
aaaacaaaca aacaaacaaa                                                   20


<210>  9296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9296
cuccccuuuu uacuuuuuga                                                   20


<210>  9297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9297
ccuuuuuacu uuuugaagcc                                                   20


<210>  9298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9298
ccuugcucuc uccuuccuca                                                   20


<210>  9299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9299
cuccuuccuc acauacucac                                                   20


<210>  9300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9300
ccuuccucac auacucacca                                                   20


<210>  9301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9301
uuccucacau acucaccagu                                                   20


<210>  9302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9302
cauacucacc aguacucaug                                                   20


<210>  9303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9303
ccaguacuca ugcgcuucuc                                                   20


<210>  9304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9304
ugcgcuucuc agacccaaau                                                   20


<210>  9305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9305
gacccaaaug cucugcuuau                                                   20


<210>  9306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9306
gcuuauggug gauaacccca                                                   20


<210>  9307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9307
gugggccucc cucucucucu                                                   20


<210>  9308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9308
cucucucucu cucucucucu                                                   20


<210>  9309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9309
cucucucucu cucucucucu                                                   20


<210>  9310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9310
cucucucucu cucucucucu                                                   20


<210>  9311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9311
cucucucucu cucucucucu                                                   20


<210>  9312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9312
cucucucucu cucucucugu                                                   20


<210>  9313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9313
cucucucucu cucucuguca                                                   20


<210>  9314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9314
cucucucucu cucugucauu                                                   20


<210>  9315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9315
cucucucucu cugucauuac                                                   20


<210>  9316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9316
cucucucucu gucauuacca                                                   20


<210>  9317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9317
cucucucugu cauuaccaac                                                   20


<210>  9318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9318
cucucuguca uuaccaacuu                                                   20


<210>  9319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9319
cucugucauu accaacuucu                                                   20


<210>  9320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9320
cugucauuac caacuucuau                                                   20


<210>  9321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9321
gucauuacca acuucuauaa                                                   20


<210>  9322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9322
gaauacaaag ggcauucuca                                                   20


<210>  9323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9323
uuucccugaa auguacuuug                                                   20


<210>  9324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9324
agccgucuuu caggguagca                                                   20


<210>  9325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9325
agacucuagc cgucuuucag                                                   20


<210>  9326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9326
ucaagacucu agccgucuuu                                                   20


<210>  9327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9327
aguggugggu guuuuguuuu                                                   20


<210>  9328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9328
accaaaauca agauacagaa                                                   20


<210>  9329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9329
ugccccuuug cugucaaucc                                                   20


<210>  9330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9330
gaccccuucc uucuaaccac                                                   20


<210>  9331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9331
acacuguggu gguagguggg                                                   20


<210>  9332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9332
uacaggauau cgucuuuugu                                                   20


<210>  9333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9333
guggaagaaa uuaaacacaa                                                   20


<210>  9334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9334
acaccaugga ugaaucccag                                                   20


<210>  9335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9335
uucauucuuc uacuguugag                                                   20


<210>  9336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9336
acaguagaag aaugaaagag                                                   20


<210>  9337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9337
uagguaaaca ucuaaggcau                                                   20


<210>  9338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9338
aaaugccuua gauguuuacc                                                   20


<210>  9339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9339
aaaccuuuuc uguguucucg                                                   20


<210>  9340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9340
aacucaaaac cuuuucugug                                                   20


<210>  9341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9341
cuggacucaa acucaaaacc                                                   20


<210>  9342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9342
uuuugucauc cuccaggcug                                                   20


<210>  9343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9343
aggcugcccc ccucccaccc                                                   20


<210>  9344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9344
caccccauuc ccuggagagu                                                   20


<210>  9345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9345
agggaauggg gugggagggg                                                   20


<210>  9346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9346
ccagggaaug gggugggagg                                                   20


<210>  9347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9347
aaacccuaua ucccagcuau                                                   20


<210>  9348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9348
gcuaccaaau gucauccuau                                                   20


<210>  9349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9349
ccacuacacu aaggaaauga                                                   20


<210>  9350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9350
acuacacuaa ggaaaugaug                                                   20


<210>  9351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9351
ucccaucauu uccuuagugu                                                   20


<210>  9352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9352
gggucagaga uaacuuaagu                                                   20


<210>  9353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9353
gacccagagu ccaauuuauu                                                   20


<210>  9354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9354
gaacaccaca cuuaaguuau                                                   20


<210>  9355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9355
uaggacuccg aacaccacac                                                   20


<210>  9356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9356
gaaauggacu uaguugaccu                                                   20


<210>  9357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9357
cccauuagca gcauggagag                                                   20


<210>  9358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9358
augcugcuaa ugggggaggu                                                   20


<210>  9359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9359
ccaugcugcu aaugggggag                                                   20


<210>  9360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9360
uugacucucc augcugcuaa                                                   20


<210>  9361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9361
cacaacacuc cagggaggca                                                   20


<210>  9362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9362
agggaggcag cugcugccca                                                   20


<210>  9363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9363
cuggaguguu gugugagacc                                                   20


<210>  9364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9364
cccuccccca uccucaucag                                                   20


<210>  9365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9365
cccauccuca ucagcuuggc                                                   20


<210>  9366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9366
ucagcuuggc cauggcaggg                                                   20


<210>  9367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9367
gaucccccag cccugccaug                                                   20


<210>  9368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9368
cccagggguc cuucugcuuc                                                   20


<210>  9369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9369
agugggacca gagcugagug                                                   20


<210>  9370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9370
ggucccacug gaggcccugu                                                   20


<210>  9371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9371
gcucuggucc cacuggaggc                                                   20


<210>  9372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9372
ggcaguggcg gaagcugauu                                                   20


<210>  9373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9373
ccguaccuuc cuuuaaucag                                                   20


<210>  9374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9374
acuccccgua ccuuccuuua                                                   20


<210>  9375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9375
cccuugcauu guugucuaag                                                   20


<210>  9376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9376
guucuguuuu cuucaguuuc                                                   20


<210>  9377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9377
guuuauugcc aguagugguc                                                   20


<210>  9378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9378
cuguuuauug ccaguagugg                                                   20


<210>  9379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9379
cccauggggc uucacuuucu                                                   20


<210>  9380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9380
gguuucuuaa guaauguagg                                                   20


<210>  9381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9381
aggauguauu uauugcccua                                                   20


<210>  9382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9382
ugcuuagccu guguagcuca                                                   20


<210>  9383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9383
cucuugcuua gccuguguag                                                   20


<210>  9384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9384
cacucuugcu uagccugugu                                                   20


<210>  9385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9385
cucacucuug cuuagccugu                                                   20


<210>  9386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9386
cauguggccu gucagcauca                                                   20


<210>  9387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9387
cccauguggc cugucagcau                                                   20


<210>  9388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9388
cagcccacgu cuucccacuc                                                   20


<210>  9389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9389
cagcucccag cccacgucuu                                                   20


<210>  9390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9390
ucugugcaug gccucuaaac                                                   20


<210>  9391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9391
aaacugggca gugaccaugg                                                   20


<210>  9392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9392
ccacucugga ccuggguugc                                                   20


<210>  9393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9393
ggaccugggu ugccccucug                                                   20


<210>  9394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9394
guaaacaagg agguuguaau                                                   20


<210>  9395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9395
uuguuuacag aggggcaacc                                                   20


<210>  9396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9396
aauacccuaa ugucuuauaa                                                   20


<210>  9397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9397
caucuuggca aaaauugcau                                                   20


<210>  9398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9398
ccauacuccc aucuuggcaa                                                   20


<210>  9399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9399
ccccauacuc ccaucuuggc                                                   20


<210>  9400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9400
ucucucccca uacucccauc                                                   20


<210>  9401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9401
gggccguuuc cacucuucuc                                                   20


<210>  9402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9402
gugagaugag auaucaaagg                                                   20


<210>  9403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9403
cugagcucug ggccguuucc                                                   20


<210>  9404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9404
ucucacugag cucugggccg                                                   20


<210>  9405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9405
cuaaucucca auuggcaaag                                                   20


<210>  9406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9406
aauuggcaaa gccagacuug                                                   20


<210>  9407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9407
uagcucauuc cuaaugauuu                                                   20


<210>  9408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9408
uuccuaauga uuuaucacca                                                   20


<210>  9409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9409
uccguaaaau aggaauaaua                                                   20


<210>  9410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9410
uuuuauuuuc auacaaaccc                                                   20


<210>  9411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9411
aggaacuuua caaauacgca                                                   20


<210>  9412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9412
gcucuaggaa cuuuacaaau                                                   20


<210>  9413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9413
gagcuuguga acuaaaaugc                                                   20


<210>  9414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9414
gagcacuuac ucugcucuag                                                   20


<210>  9415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9415
ugguauuuau uaguuacacc                                                   20


<210>  9416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9416
gcagaaacaa aguuaucagg                                                   20


<210>  9417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9417
cuuuucccuu uucuucugac                                                   20


<210>  9418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9418
cccuuuuccc uuuucuucug                                                   20


<210>  9419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9419
cccugacguc auauucuuuu                                                   20


<210>  9420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9420
uaauugucca uuuuucaucu                                                   20


<210>  9421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9421
ucauaauugu ccauuuuuca                                                   20


<210>  9422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9422
ccuccucaua auuguccauu                                                   20


<210>  9423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9423
ccccuccuca uaauugucca                                                   20


<210>  9424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9424
uuuacaauuu ugggagucca                                                   20


<210>  9425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9425
caaaauugua aaggagguga                                                   20


<210>  9426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9426
augggaauga aauaauuugu                                                   20


<210>  9427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9427
aucaccaaga gagccuuccg                                                   20


<210>  9428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9428
uggugaugga gaauuggauu                                                   20


<210>  9429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9429
cuuggugaug gagaauugga                                                   20


<210>  9430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9430
uucggaaggc ucucuuggug                                                   20


<210>  9431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9431
aucgguggcc guuugcccag                                                   20


<210>  9432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9432
ccaucggugg ccguuugccc                                                   20


<210>  9433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9433
ucuaccccac ccacgccccc                                                   20


<210>  9434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9434
gauuagggug ggggcguggg                                                   20


<210>  9435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9435
aggaaggguu uggccucuga                                                   20


<210>  9436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9436
uagacauaac acaccagggu                                                   20


<210>  9437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9437
uuucuggccu auguuauuac                                                   20


<210>  9438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9438
uacuuaugca caccuggggc                                                   20


<210>  9439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9439
augccccagg ugugcauaag                                                   20


<210>  9440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9440
cuacagauaa cucccaaguc                                                   20


<210>  9441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9441
caaguccugu cuagcugccu                                                   20


<210>  9442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9442
gaguagaacc cccuauaaac                                                   20


<210>  9443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9443
gagguacuga uggaccuugg                                                   20


<210>  9444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9444
gccuguugug augcuuacau                                                   20


<210>  9445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9445
aaccacaggg aucacaacac                                                   20


<210>  9446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9446
caaaccacag ggaucacaac                                                   20


<210>  9447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9447
aaacucucaa accacaggga                                                   20


<210>  9448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9448
augggcccuc aaucagcaca                                                   20


<210>  9449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9449
aucagcacau acacacaaaa                                                   20


<210>  9450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9450
aagacaggca auucaauacc                                                   20


<210>  9451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9451
caugguggca aggguuuuug                                                   20


<210>  9452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9452
gccccaggcu cccauggugg                                                   20


<210>  9453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9453
aaauggugcu gucauuuuuc                                                   20


<210>  9454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9454
gaaaaaugac agcaccauuu                                                   20


<210>  9455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9455
cagaaaaaug acagcaccau                                                   20


<210>  9456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9456
aaauuacaag gguguuuuca                                                   20


<210>  9457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9457
ggaaaagaga acaaacaaac                                                   20


<210>  9458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9458
uuuccagagc ugcaguaugu                                                   20


<210>  9459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9459
uugguuuguu uguucucuuu                                                   20


<210>  9460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9460
ggaucccuuc ucuuugguuu                                                   20


<210>  9461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9461
uaugugaaaa gucaauugau                                                   20


<210>  9462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9462
gguuauccua aagccuucau                                                   20


<210>  9463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9463
ccuccgguua uccuaaagcc                                                   20


<210>  9464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9464
ugggacaagg cauucuguaa                                                   20


<210>  9465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9465
cacccugucc cccaucugug                                                   20


<210>  9466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9466
guaacaccac ugggaugguc                                                   20


<210>  9467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9467
uagggcuauc ccuuugcccc                                                   20


<210>  9468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9468
aguucugccc uggacacuug                                                   20


<210>  9469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9469
gccugggaaa ugguuucaca                                                   20


<210>  9470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9470
gucucugccu gggaaauggu                                                   20


<210>  9471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9471
ggucagcucu ggacacacag                                                   20


<210>  9472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9472
ggacacacag caaaagugag                                                   20


<210>  9473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9473
cuuuugcugu guguccagag                                                   20


<210>  9474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9474
gaacucacuu uugcugugug                                                   20


<210>  9475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9475
uuccugcuuc aggcuacucu                                                   20


<210>  9476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9476
ucccucuuuc cugcuucagg                                                   20


<210>  9477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9477
cuucccucuu uccugcuuca                                                   20


<210>  9478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9478
ucucuucccu cuuuccugcu                                                   20


<210>  9479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9479
aauccuugcc uugaaccugc                                                   20


<210>  9480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9480
uccagaaggg guaacugucu                                                   20


<210>  9481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9481
ccaggcucuu ccagaagggg                                                   20


<210>  9482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9482
ccugccuugu acaacccucu                                                   20


<210>  9483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9483
ugccuuguac aacccucucu                                                   20


<210>  9484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9484
cuccucaccg acuuucucuc                                                   20


<210>  9485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9485
ccucaccgac uuucucuccc                                                   20


<210>  9486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9486
ucaccgacuu ucucucccag                                                   20


<210>  9487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9487
ccgacuuucu cucccagcag                                                   20


<210>  9488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9488
cccagcagcc agcaggggcc                                                   20


<210>  9489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9489
cagcagccag caggggccug                                                   20


<210>  9490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9490
agguuccacu gugagugcuc                                                   20


<210>  9491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9491
caguggaacc uagaguggga                                                   20


<210>  9492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9492
cucucucucu cucucucacu                                                   20


<210>  9493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9493
cucucucucu cucucacuau                                                   20


<210>  9494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9494
cucucucucu cucacuaugc                                                   20


<210>  9495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9495
cucucucucu cacuaugcuc                                                   20


<210>  9496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9496
cucucucuca cuaugcuccc                                                   20


<210>  9497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9497
cucucucacu augcucccaa                                                   20


<210>  9498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9498
cucucacuau gcucccaaga                                                   20


<210>  9499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9499
cucacuaugc ucccaagagg                                                   20


<210>  9500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9500
cacuaugcuc ccaagaggag                                                   20


<210>  9501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9501
cuaugcuccc aagaggaguc                                                   20


<210>  9502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9502
caagaggagu cuuacaucaa                                                   20


<210>  9503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9503
ugggagcaua gugagagaga                                                   20


<210>  9504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9504
ucuugggagc auagugagag                                                   20


<210>  9505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9505
aaucucccuc acuggauguc                                                   20


<210>  9506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9506
cucacuggau gucacaguca                                                   20


<210>  9507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9507
cuggauguca cagucauagg                                                   20


<210>  9508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9508
uaugacuguc cauggggaaa                                                   20


<210>  9509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9509
ucucuuauga cuguccaugg                                                   20


<210>  9510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9510
cacauggaag gaagcaagau                                                   20


<210>  9511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9511
cauggaagga agcaagaucu                                                   20


<210>  9512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9512
acuccucccc caguguugag                                                   20


<210>  9513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9513
ucccccagug uugaguggac                                                   20


<210>  9514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9514
cccaguguug aguggacagg                                                   20


<210>  9515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9515
acacuggggg aggaguagag                                                   20


<210>  9516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9516
cuguccacuc aacacugggg                                                   20


<210>  9517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9517
agcuuagggg augcuagcua                                                   20


<210>  9518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9518
agcucuagcu uaggggaugc                                                   20


<210>  9519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9519
agcucuagcu cuagcuuagg                                                   20


<210>  9520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9520
agcaaagucc uuccaugcag                                                   20


<210>  9521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9521
uuaaguguuu acaggucauu                                                   20


<210>  9522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9522
agcucauuaa guguuuacag                                                   20


<210>  9523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9523
uuacaaaagg augcacagug                                                   20


<210>  9524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9524
guuugaucaa gucagauuuu                                                   20


<210>  9525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9525
gguuagcagg ccaaggauau                                                   20


<210>  9526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9526
uauauccuug gccugcuaac                                                   20


<210>  9527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9527
cauauauccu uggccugcua                                                   20


<210>  9528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9528
ugaauugaau uagaacauuc                                                   20


<210>  9529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9529
aucggcucuu accagucacu                                                   20


<210>  9530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9530
uaccagucac uaccuacguc                                                   20


<210>  9531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9531
ggaaggugca aagugccauc                                                   20


<210>  9532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9532
uacucuucuc uuucucugaa                                                   20


<210>  9533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9533
ucucuuucuc ugaacuauca                                                   20


<210>  9534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9534
uucucugaac uaucaccuua                                                   20


<210>  9535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9535
gaacuaucac cuuacuauag                                                   20


<210>  9536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9536
guggccucuu uugucucauu                                                   20


<210>  9537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9537
uuugucucau uucucccuuu                                                   20


<210>  9538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9538
uuucucccuu ugcugaugau                                                   20


<210>  9539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9539
cuuugcugau gauccaguag                                                   20


<210>  9540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9540
acuggaucau cagcaaaggg                                                   20


<210>  9541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9541
gcaggaugga agugagccag                                                   20


<210>  9542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9542
cuuccauccu gcagaggaag                                                   20


<210>  9543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9543
cccuucuauc accuggcuca                                                   20


<210>  9544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9544
gccaaugaag cggugggucc                                                   20


<210>  9545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9545
gcaacacccu gaccuuuaug                                                   20


<210>  9546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9546
uggauuuugu gcauagcaau                                                   20


<210>  9547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9547
augggccucu uggauuuugu                                                   20


<210>  9548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9548
ccaccuccau gggccucuug                                                   20


<210>  9549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9549
ucuccccacc uccaugggcc                                                   20


<210>  9550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9550
agagcagggg ucuucucuuu                                                   20


<210>  9551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9551
ugagggucug ccaggugggu                                                   20


<210>  9552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9552
uugggggagg acaucacucu                                                   20


<210>  9553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9553
cccaaagaga agaccccugc                                                   20


<210>  9554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9554
uagcagggcu ggggugaguc                                                   20


<210>  9555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9555
ccccagcccu gcuaagagug                                                   20


<210>  9556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9556
cagacuuuug acucacccca                                                   20


<210>  9557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9557
auucucccag acuuuugacu                                                   20


<210>  9558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9558
acaccuccau ucucccagac                                                   20


<210>  9559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9559
auguagacgg guguguggcu                                                   20


<210>  9560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9560
uuaaggugac ccagcagccc                                                   20


<210>  9561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9561
acgcaccacu ucugugccca                                                   20


<210>  9562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9562
ucugacaggc ccugcugguu                                                   20


<210>  9563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9563
caggacaugc agcagugugu                                                   20


<210>  9564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9564
cuaccgcgac cccuaucagu                                                   20


<210>  9565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9565
guccagccca gccugggugu                                                   20


<210>  9566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9566
gggcacaccc ugugaucuug                                                   20


<210>  9567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9567
ccaccuucuc agggcacacc                                                   20


<210>  9568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9568
cagccuccaa gcauugcauc                                                   20


<210>  9569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9569
aagcauugca ucauccuggu                                                   20


<210>  9570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9570
ggcaccugca uuuguuuuuc                                                   20


<210>  9571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9571
gcccagcaca cuaagccuau                                                   20


<210>  9572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9572
gcucugccca gcacacuaag                                                   20


<210>  9573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9573
gcucagcucu gcccagcaca                                                   20


<210>  9574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9574
accuacucac auaagaucag                                                   20


<210>  9575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9575
cauaagauca guaaagagaa                                                   20


<210>  9576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9576
uuacugaucu uaugugagua                                                   20


<210>  9577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9577
ucugccugcu uccuucucuu                                                   20


<210>  9578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9578
ccuugucacc ucaucugccu                                                   20


<210>  9579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9579
cugguuucuc cccuugucac                                                   20


<210>  9580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9580
gaggagcuag agacuugugg                                                   20


<210>  9581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9581
gagaacuggc agucuggcug                                                   20


<210>  9582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9582
ucagagaacu ggcagucugg                                                   20


<210>  9583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9583
agcuccucag agaacuggca                                                   20


<210>  9584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9584
cugauggaug uacuaauaug                                                   20


<210>  9585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9585
gauggaugua cuaauaugua                                                   20


<210>  9586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9586
gaugacuguc caacucaucc                                                   20


<210>  9587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9587
uccagaaacu acguuugucu                                                   20


<210>  9588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9588
ucaaugcccc cccaccaccc                                                   20


<210>  9589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9589
caucaaugcc cccccaccac                                                   20


<210>  9590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9590
cuggcuuuuc ugggagauca                                                   20


<210>  9591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9591
cagaaaagcc agcgagaaau                                                   20


<210>  9592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9592
ggucucgggg cccaagccaa                                                   20


<210>  9593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9593
gggcccaagc caaagagcug                                                   20


<210>  9594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9594
uuggcuuggg ccccgagacc                                                   20


<210>  9595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9595
agcucuuugg cuugggcccc                                                   20


<210>  9596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9596
accaggccuu agguucugug                                                   20


<210>  9597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9597
ccuugcacau ggcugucuug                                                   20


<210>  9598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9598
cacagagcug caggggugug                                                   20


<210>  9599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9599
gugggaguga cggaagggcg                                                   20


<210>  9600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9600
agcacugugg cccagaaggg                                                   20


<210>  9601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9601
ugaaggaaua aggcacgaug                                                   20


<210>  9602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9602
ugggaaaggu ugcacauucu                                                   20


<210>  9603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9603
ucuaagugau auuucuuccc                                                   20


<210>  9604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9604
aagugauauu ucuucccagg                                                   20


<210>  9605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9605
uuaucuauaa aauggggcua                                                   20


<210>  9606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9606
ggcucuuuau cuauaaaaug                                                   20


<210>  9607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9607
uguguagcug acuuuagagu                                                   20


<210>  9608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9608
aaagucagcu acacaugagu                                                   20


<210>  9609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9609
uucaacgucc cacuuucuca                                                   20


<210>  9610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9610
agacaguguu ugccacgggc                                                   20


<210>  9611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9611
aaccccucau accuccccac                                                   20


<210>  9612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9612
uaccucccca ccaaccccau                                                   20


<210>  9613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9613
ccaccaaccc caugcaggug                                                   20


<210>  9614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9614
cugacaccug caugggguug                                                   20


<210>  9615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9615
ccggaccaaa gggguggaca                                                   20


<210>  9616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9616
accuugagug gagaggcugc                                                   20


<210>  9617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9617
agguugagcg guuuccuuca                                                   20


<210>  9618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9618
acucaagguu gagcgguuuc                                                   20


<210>  9619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9619
ccacucaagg uugagcgguu                                                   20


<210>  9620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9620
gggcagcacc ugggccacag                                                   20


<210>  9621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9621
uuccacaugc uguggcccag                                                   20


<210>  9622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9622
gccaucuguc uucucuuccu                                                   20


<210>  9623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9623
uccuccuaau ccauaagcac                                                   20


<210>  9624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9624
uaauccauaa gcaccagacc                                                   20


<210>  9625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9625
agccccaugu gcagcuccgg                                                   20


<210>  9626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9626
ggaagcugcu agaccucaag                                                   20


<210>  9627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9627
agcaggacua agauucggag                                                   20


<210>  9628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9628
gaaucuuagu ccugcuugag                                                   20


<210>  9629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9629
ccgaaucuua guccugcuug                                                   20


<210>  9630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9630
cuccgaaucu uaguccugcu                                                   20


<210>  9631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9631
ucccaggcag gccagcccag                                                   20


<210>  9632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9632
caggcaggcc agcccaggug                                                   20


<210>  9633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9633
ccugggcugg ccugccuggg                                                   20


<210>  9634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9634
agccaggcac ucaccccacu                                                   20


<210>  9635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9635
ccccacugcc aggcuguuua                                                   20


<210>  9636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9636
uagcuggugu uugucuccug                                                   20


<210>  9637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9637
ugucugcucu acuguagcuc                                                   20


<210>  9638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9638
acuguagcuc ccucccuccu                                                   20


<210>  9639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9639
cucccuccuc uccuccuuuc                                                   20


<210>  9640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9640
cuccucuccu ccuuucgguc                                                   20


<210>  9641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9641
ucuccuccuu ucgguccucu                                                   20


<210>  9642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9642
ccuccuuucg guccucugcc                                                   20


<210>  9643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9643
uccuuucggu ccucugccca                                                   20


<210>  9644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9644
uuucgguccu cugcccaggc                                                   20


<210>  9645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9645
gcccaggccu gccugaggcu                                                   20


<210>  9646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9646
ggcaggccug ggcagaggac                                                   20


<210>  9647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9647
cuggcaggca gccucaggca                                                   20


<210>  9648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9648
gugcccaggg caaagcccug                                                   20


<210>  9649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9649
gggcacccua gcccucagug                                                   20


<210>  9650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9650
cacacagguc cugugcugcc                                                   20


<210>  9651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9651
cacacacagg uccugugcug                                                   20


<210>  9652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9652
agaccaccgc ucucacacac                                                   20


<210>  9653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9653
caagaccacc gcucucacac                                                   20


<210>  9654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9654
ccgccugggc uugacuuguc                                                   20


<210>  9655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9655
ccugcccuau cccuaccugc                                                   20


<210>  9656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9656
gcuuccccgc caccauuaac                                                   20


<210>  9657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9657
gugggcugac agaugugccu                                                   20


<210>  9658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9658
gaaggcacau cugucagccc                                                   20


<210>  9659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9659
cugcccuucu cugaaggcac                                                   20


<210>  9660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9660
ggccaggccc ccagcugcuc                                                   20


<210>  9661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9661
gauguaaguu ccugcuggga                                                   20


<210>  9662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9662
uggguaggcu gccugcucug                                                   20


<210>  9663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9663
uuccuucccu ggcucuuggg                                                   20


<210>  9664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9664
ccuuccuucc cuggcucuug                                                   20


<210>  9665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9665
ggggcucucc uuccuucccu                                                   20


<210>  9666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9666
ucaggacagg guucagagcu                                                   20


<210>  9667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9667
ggacaggguu cagagcuagg                                                   20


<210>  9668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9668
gaacccuguc cugaggaguu                                                   20


<210>  9669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9669
guguagcagc caccagccua                                                   20


<210>  9670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9670
accaguuaag guauaagaca                                                   20


<210>  9671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9671
cagucggggc accucacuuc                                                   20


<210>  9672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9672
cuucaagccu ugguggauag                                                   20


<210>  9673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9673
ggcucccaag uuagacagau                                                   20


<210>  9674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9674
caaguuagac agaugagcug                                                   20


<210>  9675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9675
ucugucuaac uugggagccu                                                   20


<210>  9676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9676
cagacacaca gccaggaaau                                                   20


<210>  9677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9677
uuaaccucuc caagccucag                                                   20


<210>  9678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9678
ccaagccuca guuucuucac                                                   20


<210>  9679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9679
aagccucagu uucuucacug                                                   20


<210>  9680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9680
guuucuucac ugguaaaaug                                                   20


<210>  9681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9681
uuuaacuagu uccaucagca                                                   20


<210>  9682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9682
ucuguaaaau gggagaaccc                                                   20


<210>  9683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9683
guaaaauggg agaacccuga                                                   20


<210>  9684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9684
cauuuuacag aggaggaugc                                                   20


<210>  9685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9685
gccgaccuca ugguugacuc                                                   20


<210>  9686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9686
ugguugacuc acucagcaac                                                   20


<210>  9687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9687
cucagcaaca gaggucucca                                                   20


<210>  9688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9688
gcaacagagg ucuccacagg                                                   20


<210>  9689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9689
guugcugagu gagucaacca                                                   20


<210>  9690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9690
acaggagccc ugcccacaug                                                   20


<210>  9691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9691
uguggagacc ucuguugcug                                                   20


<210>  9692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9692
ugugggcagg gcuccugugg                                                   20


<210>  9693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9693
uuccauuuug uucuggcaag                                                   20


<210>  9694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9694
uucccugccc ucaaggagcu                                                   20


<210>  9695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9695
aggagcucac aguccagugg                                                   20


<210>  9696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9696
uugagggcag ggaaugaggc                                                   20


<210>  9697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9697
caguccagug gcucugucuu                                                   20


<210>  9698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9698
gucuuuaaua ucuauaagag                                                   20


<210>  9699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9699
uauagauauu aaagacagag                                                   20


<210>  9700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9700
uguaauauga uuaaucacuu                                                   20


<210>  9701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9701
uucgggugcu ucccugagug                                                   20


<210>  9702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9702
gggaagcacc cgaaagagaa                                                   20


<210>  9703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9703
ugccacucag ggaagcaccc                                                   20


<210>  9704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9704
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  9705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9705
gucucaaaaa aaaaaaaaaa                                                   20


<210>  9706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9706
uguugcccag gcuggggugc                                                   20


<210>  9707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9707
gcucaccacc ucugccuccu                                                   20


<210>  9708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9708
ccaccucugc cuccuggguu                                                   20


<210>  9709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9709
gccuccuggg uucaagcaau                                                   20


<210>  9710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9710
uggguucaag caauucuccu                                                   20


<210>  9711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9711
ucccucagcc uccugaguag                                                   20


<210>  9712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9712
cucagccucc ugaguagcug                                                   20


<210>  9713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9713
gccuccugag uagcugggau                                                   20


<210>  9714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9714
ugaguagcug ggauuacagg                                                   20


<210>  9715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9715
ggaggcugag ggaggagaau                                                   20


<210>  9716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9716
auuaaaaaua uaaacuuagc                                                   20


<210>  9717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9717
ucucuauuaa aaauauaaac                                                   20


<210>  9718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9718
auguugguca ggcuggucuc                                                   20


<210>  9719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9719
aacucuugac cucaggugau                                                   20


<210>  9720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9720
ugaccucagg ugaucuaccc                                                   20


<210>  9721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9721
ggugaucuac ccaccucggc                                                   20


<210>  9722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9722
gccucccaaa gugcuggaau                                                   20


<210>  9723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9723
caaagugcug gaauuacaga                                                   20


<210>  9724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9724
cgucuguaau uccagcacuu                                                   20


<210>  9725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9725
ucucacauaa aaauuuaaga                                                   20


<210>  9726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9726
cauaaaaauu uaagacggga                                                   20


<210>  9727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9727
gaaugcaucu uccuguuuuc                                                   20


<210>  9728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9728
gccucucuac auuccaaaac                                                   20


<210>  9729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9729
cuacauucca aaacagccuu                                                   20


<210>  9730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9730
acauuccaaa acagccuuuu                                                   20


<210>  9731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9731
ggcuaacaga gcuucaggga                                                   20


<210>  9732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9732
guuagccuga gauuucaccu                                                   20


<210>  9733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9733
cugaagcucu guuagccuga                                                   20


<210>  9734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9734
cuccacagag aagcuguacc                                                   20


<210>  9735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9735
acagagaagc uguaccacca                                                   20


<210>  9736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9736
guggagugag gcauauuuuu                                                   20


<210>  9737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9737
guuuuccagg acuucuggug                                                   20


<210>  9738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9738
caguuuucca ggacuucugg                                                   20


<210>  9739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9739
agacuaucag aaugauauga                                                   20


<210>  9740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9740
gauuguugcu uugauaagua                                                   20


<210>  9741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9741
aaaugagcuu acaguuuaug                                                   20


<210>  9742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9742
uuuggaggga ccugaucucu                                                   20


<210>  9743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9743
gcaaaucugc uauccaucau                                                   20


<210>  9744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9744
aaagucaggg aguagguaaa                                                   20


<210>  9745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9745
cugacuuugg agcucagcaa                                                   20


<210>  9746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9746
cuccuggcuc uccucuacau                                                   20


<210>  9747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9747
uggcucuccu cuacauucug                                                   20


<210>  9748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9748
ccucuacauu cugugagcaa                                                   20


<210>  9749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9749
ucuacauucu gugagcaaac                                                   20


<210>  9750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9750
acauucugug agcaaacgga                                                   20


<210>  9751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9751
cagaauguag aggagagcca                                                   20


<210>  9752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9752
gccuaauaaa acugcacaga                                                   20


<210>  9753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9753
ucugaaucug augaagaagu                                                   20


<210>  9754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9754
cuagcacaga uuugagcucu                                                   20


<210>  9755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9755
aaucugugcu agcgagaaac                                                   20


<210>  9756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9756
gccaucacac acuuuguaca                                                   20


<210>  9757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9757
gguauugcuc cuaaagaaag                                                   20


<210>  9758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9758
uaaagaaaga gccagcuucc                                                   20


<210>  9759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9759
uucuuuagga gcaauaccug                                                   20


<210>  9760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9760
uaucuuccuc caacauccaa                                                   20


<210>  9761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9761
aacauccaaa agcaguguuc                                                   20


<210>  9762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9762
uuucacuggu auuucuuaaa                                                   20


<210>  9763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9763
uuguguugua auguucuuga                                                   20


<210>  9764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9764
gaugaugauu gaaaacaguu                                                   20


<210>  9765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9765
gaucauggua gcacaguaga                                                   20


<210>  9766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9766
acugugcuac caugaucaga                                                   20


<210>  9767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9767
uucugcucua cugugcuacc                                                   20


<210>  9768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9768
auuggugauc aaaagaaaua                                                   20


<210>  9769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9769
ccuggucaca uaguuucugg                                                   20


<210>  9770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9770
aagagaauca agucucgagu                                                   20


<210>  9771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9771
uagagauuaa guaccucccc                                                   20


<210>  9772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9772
aguggguaaa augagcuggg                                                   20


<210>  9773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9773
agacuugauu cucuuagaga                                                   20


<210>  9774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9774
uuuuacccac ucgagacuug                                                   20


<210>  9775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9775
uuccccagcu cauuuuaccc                                                   20


<210>  9776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9776
cugguucacu ccuuccccag                                                   20


<210>  9777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9777
cagaagacac agccagacuu                                                   20


<210>  9778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9778
uguccaaaca ccuccuuguc                                                   20


<210>  9779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9779
uugucuuuua aggccugggc                                                   20


<210>  9780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9780
aagccaguag ccaucccccu                                                   20


<210>  9781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9781
gcauuugucc uggcaauggg                                                   20


<210>  9782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9782
cauugccagg acaaaugcag                                                   20


<210>  9783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9783
uuccugcucc cauugccagg                                                   20


<210>  9784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9784
aaaccugguc acuccuaguc                                                   20


<210>  9785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9785
uagucccaag auggagaagc                                                   20


<210>  9786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9786
aucuugggac uaggagugac                                                   20


<210>  9787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9787
ggaggcucug accaggugga                                                   20


<210>  9788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9788
ugaggcugca gaauggggcu                                                   20


<210>  9789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9789
gaccaggugg aaagccagaa                                                   20


<210>  9790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9790
ugguuggacc ccauucuggc                                                   20


<210>  9791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9791
uugcagccac cugccuuuuc                                                   20


<210>  9792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9792
cuucuccagg cauugugacu                                                   20


<210>  9793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9793
aggcauugug acuuuuuauu                                                   20


<210>  9794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9794
uggaaugccu guccaggcug                                                   20


<210>  9795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9795
gagcacugca acaauuuucu                                                   20


<210>  9796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9796
gaggaagcaa uagccuacug                                                   20


<210>  9797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9797
ggacccucuc cuccaccuau                                                   20


<210>  9798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9798
ccuccaccua uucacagaug                                                   20


<210>  9799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9799
uccaccuauu cacagauggg                                                   20


<210>  9800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9800
accuauucac agauggggca                                                   20


<210>  9801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9801
cuccuaucca uuagauugcc                                                   20


<210>  9802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9802
uauccauuag auugcccaaa                                                   20


<210>  9803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9803
ggucugagug cagaccaagc                                                   20


<210>  9804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9804
gaccugagcg ccacacauua                                                   20


<210>  9805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9805
caauaccagu ggcucuuuca                                                   20


<210>  9806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9806
uucaggcuua caaagccuug                                                   20


<210>  9807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9807
guccugggua ggaacugcug                                                   20


<210>  9808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9808
gcaaacaccc agauggcccu                                                   20


<210>  9809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9809
uggaaaccua uagcugccag                                                   20


<210>  9810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9810
caaaauguca cauuucccug                                                   20


<210>  9811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9811
uaaaucuucu aggcggguua                                                   20


<210>  9812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9812
gacaaaagau ccagaauauu                                                   20


<210>  9813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9813
ugaaaauugg uuauuggcug                                                   20


<210>  9814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9814
uuccuuuccu gcauuucuug                                                   20


<210>  9815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9815
gcccccucgu uccuuuccug                                                   20


<210>  9816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9816
cugcccccuc guuccuuucc                                                   20


<210>  9817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9817
gugucuuuca uucccucucu                                                   20


<210>  9818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9818
aagccaugua ggcuuccagc                                                   20


<210>  9819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9819
gaaugugccg cucgaagcca                                                   20


<210>  9820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9820
gaagaguacc acucagccga                                                   20


<210>  9821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9821
ucagaguucu cagaaugugc                                                   20


<210>  9822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9822
gccgacacug cccccaugac                                                   20


<210>  9823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9823
ucuuugacuc acacuugccu                                                   20


<210>  9824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9824
uugacucaca cuugccuggc                                                   20


<210>  9825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9825
cacuugccug gcaggacucc                                                   20


<210>  9826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9826
ccaaacagaa cagagaugcu                                                   20


<210>  9827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9827
guucuguuug gggaguccug                                                   20


<210>  9828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9828
gccgggcaca agagagcagg                                                   20


<210>  9829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9829
ugugcccggc ugagcaucuc                                                   20


<210>  9830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9830
cuugugcccg gcugagcauc                                                   20


<210>  9831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9831
ugcugcacug ugguuucccc                                                   20


<210>  9832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9832
gccuuuucag uggguggcug                                                   20


<210>  9833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9833
ucugccuuuu cagugggugg                                                   20


<210>  9834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9834
uggccagccu gcucucccaa                                                   20


<210>  9835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9835
cccaaagaag gaauaacaga                                                   20


<210>  9836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9836
caaagaagga auaacagaac                                                   20


<210>  9837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9837
gacuacuucu gguuuguaaa                                                   20


<210>  9838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9838
cacuucaaga agaacauugg                                                   20


<210>  9839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9839
gcaucgggac acccagaaaa                                                   20


<210>  9840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9840
aaggcaaaaa gcaaauagca                                                   20


<210>  9841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9841
uucugcuauu ugcuuuuugc                                                   20


<210>  9842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9842
gucucugucu cccccaagcc                                                   20


<210>  9843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9843
gucuccccca agcccuccua                                                   20


<210>  9844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9844
cccaagcccu ccuagucaga                                                   20


<210>  9845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9845
uagucagaac guucucucag                                                   20


<210>  9846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9846
cagcauuuca gcagguacug                                                   20


<210>  9847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9847
gcauuucagc agguacugcu                                                   20


<210>  9848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9848
ccuggaaaua cagcugaugu                                                   20


<210>  9849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9849
guaaauacau cagcuguauu                                                   20


<210>  9850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9850
auauaauuuc aagacuugau                                                   20


<210>  9851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9851
cuauauaauu ucaagacuug                                                   20


<210>  9852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9852
ccuaccagug agcgcccacc                                                   20


<210>  9853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9853
cugguagggg aggcauguga                                                   20


<210>  9854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9854
aaacuauuaa aacagagcgu                                                   20


<210>  9855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9855
guuuuaauag uuuggagcaa                                                   20


<210>  9856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9856
uuauacuucu ggguccaccc                                                   20


<210>  9857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9857
ugcagccgca gggguagacu                                                   20


<210>  9858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9858
cuaagcuuca acuacccuuu                                                   20


<210>  9859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9859
aagcuucaac uacccuuucu                                                   20


<210>  9860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9860
ugccucuuca caggguuacu                                                   20


<210>  9861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9861
ucacaggguu acucaugagg                                                   20


<210>  9862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9862
ugaggugagu cucaauuuga                                                   20


<210>  9863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9863
ugaguaaccc ugugaagagg                                                   20


<210>  9864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9864
ccucaugagu aacccuguga                                                   20


<210>  9865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9865
auuugacaau acuccucaaa                                                   20


<210>  9866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9866
ucaaagggcu uacucaaaaa                                                   20


<210>  9867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9867
aagggcuuac ucaaaaaaaa                                                   20


<210>  9868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9868
aaaaaaaaau gugauuuuau                                                   20


<210>  9869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9869
uuacuaacag cacaauggac                                                   20


<210>  9870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9870
agcuuuuuug gcuuaugaaa                                                   20


<210>  9871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9871
gauccucuag cuuuuuuggc                                                   20


<210>  9872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9872
ccgauccucu agcuuuuuug                                                   20


<210>  9873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9873
gaaacggcuu caaggguguc                                                   20


<210>  9874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9874
aacacauuuc accuacaagu                                                   20


<210>  9875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9875
ucagguaguc agccgaguga                                                   20


<210>  9876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9876
gcugacuacc ugaugaguga                                                   20


<210>  9877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9877
cucggcugac uaccugauga                                                   20


<210>  9878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9878
uuuaccuucu uguccaaccc                                                   20


<210>  9879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9879
cucccucaaa ugcauaccuc                                                   20


<210>  9880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9880
cccucaaaug cauaccuccu                                                   20


<210>  9881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9881
cucaaaugca uaccuccuuc                                                   20


<210>  9882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9882
aaugcauacc uccuucucuu                                                   20


<210>  9883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9883
uucucuuucc uccagcuccc                                                   20


<210>  9884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9884
uuccuccagc ucccuaagcu                                                   20


<210>  9885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9885
agcucccuaa gcuguuguuc                                                   20


<210>  9886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9886
cuaagcuguu guucagggca                                                   20


<210>  9887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9887
ucaggcugcc agagcaagag                                                   20


<210>  9888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9888
ggcagccuga agagcugucu                                                   20


<210>  9889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9889
ugcucuggca gccugaagag                                                   20


<210>  9890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9890
cuugcucugg cagccugaag                                                   20


<210>  9891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9891
acaugcauuc ccaccucccg                                                   20


<210>  9892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9892
cggaagcagg ggacacagcu                                                   20


<210>  9893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9893
gugacggagg guggguaacc                                                   20


<210>  9894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9894
gucacagagu ggccagcugu                                                   20


<210>  9895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9895
cuaccugggu cuaucauuuu                                                   20


<210>  9896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9896
accugggucu aucauuuuag                                                   20


<210>  9897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9897
uaaaugggaa gggccaauua                                                   20


<210>  9898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9898
gagaacaacu cuaccugagg                                                   20


<210>  9899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9899
gagauaucug uaauuggccc                                                   20


<210>  9900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9900
accugaggga gggggaaauc                                                   20


<210>  9901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9901
gguagaguug uucucagaga                                                   20


<210>  9902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9902
cucagguaga guuguucuca                                                   20


<210>  9903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9903
caaaacaacg gugggcagaa                                                   20


<210>  9904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9904
acagcaucug gcagacgaac                                                   20


<210>  9905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9905
caccaucugg uuucacccgg                                                   20


<210>  9906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9906
uaggcaaggg auguuagcac                                                   20


<210>  9907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9907
gugauuucua uggugggugu                                                   20


<210>  9908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9908
cugugauuuc uauggugggu                                                   20


<210>  9909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9909
cacuuucucu gagggcaugg                                                   20


<210>  9910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9910
gagggcaugg aggggaggca                                                   20


<210>  9911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9911
gagaaagugg gagugcuggc                                                   20


<210>  9912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9912
augcccucag agaaaguggg                                                   20


<210>  9913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9913
ccuccaugcc cucagagaaa                                                   20


<210>  9914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9914
ggccuccuca uuuaauucuc                                                   20


<210>  9915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9915
ucauuuaauu cucucugcau                                                   20


<210>  9916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9916
uuuaauucuc ucugcaucag                                                   20


<210>  9917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9917
cugcaucaga ggaagaguca                                                   20


<210>  9918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9918
gcaucagagg aagagucacc                                                   20


<210>  9919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9919
gaugcagaga gaauuaaaug                                                   20


<210>  9920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9920
uccucugaug cagagagaau                                                   20


<210>  9921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9921
gauccaggac agagcuggcu                                                   20


<210>  9922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9922
guccuggauc ugaggaacac                                                   20


<210>  9923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9923
ggacgccaca ugggucaacc                                                   20


<210>  9924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9924
gguugaccca uguggcgucc                                                   20


<210>  9925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9925
gacccuccaa ggugacaaag                                                   20


<210>  9926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9926
aaggugacaa agaccucacu                                                   20


<210>  9927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9927
cuagacugua ucucauuuuu                                                   20


<210>  9928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9928
uuuuuccagc cucagugagc                                                   20


<210>  9929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9929
gugagccggc cccagcuggc                                                   20


<210>  9930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9930
cugaggcugg aaaaaugaga                                                   20


<210>  9931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9931
gcaugccagc uggggccggc                                                   20


<210>  9932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9932
aagcagccau gcacaaaggc                                                   20


<210>  9933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9933
cuaagaaaac gaccgugccc                                                   20


<210>  9934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9934
uaaauggcga aggcagcauu                                                   20


<210>  9935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9935
uaaacgccug auauauaucc                                                   20


<210>  9936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9936
aauaaugucu auaaugcuga                                                   20


<210>  9937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9937
gcauuauaga cauuauuuga                                                   20


<210>  9938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9938
gcaaaacuac cuuuccgccu                                                   20


<210>  9939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9939
guucaucaca ugccuuacca                                                   20


<210>  9940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9940
guuacgccaa cauguuuaua                                                   20


<210>  9941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9941
auuaugaacu aacucuaauu                                                   20


<210>  9942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9942
aauuuuuguu cugaaauacu                                                   20


<210>  9943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9943
gucuguuggg auauuauguu                                                   20


<210>  9944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9944
ucuagcucug cagaaugcaa                                                   20


<210>  9945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9945
gcagaaugca aagcaagaca                                                   20


<210>  9946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9946
cuuccuuccu uccuuccuuc                                                   20


<210>  9947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9947
cucccuuccu uccuuccuuc                                                   20


<210>  9948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9948
cucccucccu uccuuccuuc                                                   20


<210>  9949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9949
ccucccuccc ucccuuccuu                                                   20


<210>  9950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9950
ccuccccucc cucccucccu                                                   20


<210>  9951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9951
ccuccccucc ccucccuccc                                                   20


<210>  9952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9952
ccuccccucc ccuccccucc                                                   20


<210>  9953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9953
ccuccccucc ccuccccucc                                                   20


<210>  9954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9954
ccuccccucc ccuccccucc                                                   20


<210>  9955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9955
ccuccccucc ccuccccucc                                                   20


<210>  9956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9956
ccuccccucc ccuccccucc                                                   20


<210>  9957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9957
ccuccccucc ccuccccucc                                                   20


<210>  9958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9958
ccuccccucc ccuccccucc                                                   20


<210>  9959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9959
ccuccccucc ccuccccucc                                                   20


<210>  9960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9960
ccuccccucc ccuccccucc                                                   20


<210>  9961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9961
ccuccccucc ccuccccucc                                                   20


<210>  9962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9962
ccuccccucc ccuccccucc                                                   20


<210>  9963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9963
cuucccuucc cuucccuucc                                                   20


<210>  9964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9964
cucccuuccc uucccuuccc                                                   20


<210>  9965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9965
uucccucccu cccuucccuu                                                   20


<210>  9966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9966
uguugacuug aagcugcuuc                                                   20


<210>  9967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9967
aaaacaucug aaaauguaaa                                                   20


<210>  9968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9968
caagaaauga ggacaggcaa                                                   20


<210>  9969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9969
agaaaugagg acaggcaagg                                                   20


<210>  9970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9970
uuucuugaga gacuccaaaa                                                   20


<210>  9971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9971
cugcauaaca gagucucuua                                                   20


<210>  9972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9972
guuaugcagu gagcuguuga                                                   20


<210>  9973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9973
uacacagggc ugccuccgca                                                   20


<210>  9974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9974
gcaccugagc ugagcuugcu                                                   20


<210>  9975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9975
ggugcggagg cagcccugug                                                   20


<210>  9976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9976
gcucaggugc ggaggcagcc                                                   20


<210>  9977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9977
ccgcacccgu cgccccccac                                                   20


<210>  9978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9978
uguaacaaag gacagcauac                                                   20


<210>  9979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9979
guuagggcau uauccguaac                                                   20


<210>  9980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9980
caugucaugg ugcuuacugc                                                   20


<210>  9981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9981
ugucauggug cuuacugccc                                                   20


<210>  9982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9982
acuacuuuug uuugugaaag                                                   20


<210>  9983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9983
aagaaccaac cuaaaauucu                                                   20


<210>  9984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9984
uaguuuuuau uuguguaauu                                                   20


<210>  9985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9985
aacucaucca cacuugguuc                                                   20


<210>  9986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9986
uccacacuug guucaggaca                                                   20


<210>  9987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9987
uucacaucag gccuucccug                                                   20


<210>  9988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9988
ucuuucacau caggccuucc                                                   20


<210>  9989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9989
gucuccucuu ucacaucagg                                                   20


<210>  9990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9990
cugcaggggc cacaggagca                                                   20


<210>  9991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9991
uguggccccu gcagggagug                                                   20


<210>  9992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9992
gggacccggc ugcagugcuu                                                   20


<210>  9993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9993
cagcaacugg caacccccug                                                   20


<210>  9994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9994
caguugcauu ccuuugccaa                                                   20


<210>  9995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9995
ucagaacagg aaaaguccag                                                   20


<210>  9996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9996
gggauguaaa gcauuuggca                                                   20


<210>  9997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9997
gguacuaugg caaacuggcc                                                   20


<210>  9998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9998
uuggccaguu ugccauagua                                                   20


<210>  9999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  9999
uagcaacgcu ucucuuuggc                                                   20


<210>  10000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10000
gcuuggccca ggaagaagcu                                                   20


<210>  10001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10001
gcuacagggg ccgugggaau                                                   20


<210>  10002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10002
agcuauuccc acggccccug                                                   20


<210>  10003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10003
gggaaaugca caggccucca                                                   20


<210>  10004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10004
uuggcgacag ggcuggaccu                                                   20


<210>  10005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10005
ucucugagcu cccccuuggg                                                   20


<210>  10006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10006
gagcuccccc uuggguuacc                                                   20


<210>  10007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10007
gagaagaguc caggcugcca                                                   20


<210>  10008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10008
cccuuggguu accuaugauu                                                   20


<210>  10009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10009
ucuggaauca uagguaaccc                                                   20


<210>  10010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10010
auggugcugg cuuugccaca                                                   20


<210>  10011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10011
guccccucua uggugcuggc                                                   20


<210>  10012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10012
agguaggccu uagguuuccc                                                   20


<210>  10013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10013
ggauucaaaa gacaccuuaa                                                   20


<210>  10014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10014
uugguccuca ggauucaaaa                                                   20


<210>  10015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10015
ccuaugacaa ggaaccuguc                                                   20


<210>  10016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10016
uaugacaagg aaccugucac                                                   20


<210>  10017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10017
aggcuuuagc aaucacagaa                                                   20


<210>  10018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10018
uccaaagaaa aguggcucag                                                   20


<210>  10019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10019
aaagaaaagu ggcucagaca                                                   20


<210>  10020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10020
gacagaaaca cugacucuua                                                   20


<210>  10021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10021
uauuucucau cagacuccga                                                   20


<210>  10022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10022
ucagacuccg aaaucacagg                                                   20


<210>  10023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10023
gaaaucacag gcuucugguc                                                   20


<210>  10024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10024
gcuugaaucu uuagaccaga                                                   20


<210>  10025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10025
gcuuuggcug gcuuggaugu                                                   20


<210>  10026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10026
uaacauccaa gccagccaaa                                                   20


<210>  10027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10027
aauggaaaag uaaaaaaauu                                                   20


<210>  10028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10028
gcacucuccu uucaaggaaa                                                   20


<210>  10029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10029
ccuuucaagg aaaaaggcuc                                                   20


<210>  10030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10030
uuucaaggaa aaaggcucua                                                   20


<210>  10031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10031
augugccagc ccacuucuuu                                                   20


<210>  10032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10032
cuuuccccau uucuggaaag                                                   20


<210>  10033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10033
ucccuuuccc cauuucugga                                                   20


<210>  10034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10034
uccucccuuu ccccauuucu                                                   20


<210>  10035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10035
uuuccacagg uucuccuccu                                                   20


<210>  10036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10036
gguccacggu uagccccugg                                                   20


<210>  10037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10037
gcugugcuca gguccacggu                                                   20


<210>  10038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10038
gaaaacgguu cuguggaagc                                                   20


<210>  10039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10039
cugccacgug ucuugugcuu                                                   20


<210>  10040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10040
cacugccacg ugucuugugc                                                   20


<210>  10041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10041
ggacucucac ugccacgugu                                                   20


<210>  10042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10042
auggucuacc ugagaccuga                                                   20


<210>  10043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10043
gguagaccau cgagcugcug                                                   20


<210>  10044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10044
ggucucaggu agaccaucga                                                   20


<210>  10045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10045
guuguucuuu agcuaccaaa                                                   20


<210>  10046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10046
uaaucuuuuu guucuuuuuc                                                   20


<210>  10047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10047
uccuaaucuu uuuguucuuu                                                   20


<210>  10048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10048
uccuccuaau cuuuuuguuc                                                   20


<210>  10049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10049
ccaaagaacu cgacuuaaau                                                   20


<210>  10050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10050
acuuaaauca ucucagcuau                                                   20


<210>  10051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10051
gcuauaggca gucaacuggg                                                   20


<210>  10052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10052
ccgaacagcc acaaucgggg                                                   20


<210>  10053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10053
gaacagccac aaucgggggg                                                   20


<210>  10054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10054
cuuuccccuc acgaucuucc                                                   20


<210>  10055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10055
uuccccucac gaucuuccug                                                   20


<210>  10056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10056
cgaucuuccu gaacagggca                                                   20


<210>  10057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10057
uucaccacuu caggacuuca                                                   20


<210>  10058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10058
gagcaccucc acagccuuuc                                                   20


<210>  10059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10059
gaggaugggu gugucugggg                                                   20


<210>  10060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10060
acagccuuuc uggcccaucc                                                   20


<210>  10061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10061
cagucaccga gccacacauu                                                   20


<210>  10062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10062
gugacuggga gaauagaauu                                                   20


<210>  10063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10063
ucccuuccuu ucauacaacc                                                   20


<210>  10064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10064
cuuccuuuca uacaacccau                                                   20


<210>  10065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10065
cguccccacc acccuggucc                                                   20


<210>  10066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10066
cuuucccaug cuugagucuc                                                   20


<210>  10067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10067
agcaugggaa agugaggcag                                                   20


<210>  10068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10068
aaaugcggcc caagagacuc                                                   20


<210>  10069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10069
ugggccgcau uuugagacuc                                                   20


<210>  10070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10070
cuggaagcgc aagucauaug                                                   20


<210>  10071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10071
ggaagcgcaa gucauaugac                                                   20


<210>  10072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10072
uccaguggcu uccaucuccc                                                   20


<210>  10073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10073
aguggcuucc aucucccuug                                                   20


<210>  10074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10074
cuuggaguca gagccaaaaa                                                   20


<210>  10075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10075
aagggagaug gaagccacug                                                   20


<210>  10076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10076
gacuccaagg gagauggaag                                                   20


<210>  10077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10077
acguccuuca aggagccagc                                                   20


<210>  10078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10078
uugaaggacg uagagcaggg                                                   20


<210>  10079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10079
ucuccuccuc cuccugcacu                                                   20


<210>  10080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10080
ccuccuccuc cugcacucuu                                                   20


<210>  10081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10081
uccuccuccu gcacucuuuc                                                   20


<210>  10082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10082
uccuccugca cucuuuccac                                                   20


<210>  10083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10083
uccugcacuc uuuccacucu                                                   20


<210>  10084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10084
ugcacucuuu ccacucugac                                                   20


<210>  10085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10085
uuccacucug accucagggc                                                   20


<210>  10086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10086
gaccucaggg ccccuugcuc                                                   20


<210>  10087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10087
gggccccuug cuccuccucc                                                   20


<210>  10088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10088
uccuccagua gccaggcgua                                                   20


<210>  10089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10089
uccaguagcc aggcguauua                                                   20


<210>  10090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10090
aguagccagg cguauuacac                                                   20


<210>  10091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10091
gcucucuaca cacucuuccu                                                   20


<210>  10092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10092
cuacacacuc uuccuggaac                                                   20


<210>  10093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10093
acacacucuu ccuggaacca                                                   20


<210>  10094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10094
uccuggaacc aucuucucaa                                                   20


<210>  10095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10095
aaauucucau ggccaacuuc                                                   20


<210>  10096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10096
uggccaacuu ccucaccucu                                                   20


<210>  10097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10097
ccucuuugga gccuuugcuu                                                   20


<210>  10098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10098
uuggagccuu ugcuucucau                                                   20


<210>  10099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10099
aaagagguga ggaaguuggc                                                   20


<210>  10100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10100
uugggccuuc ccuaauuauc                                                   20


<210>  10101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10101
uccccaccuu auuuucgugc                                                   20


<210>  10102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10102
ugccauacua uauaauucac                                                   20


<210>  10103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10103
ccccagcuag aaagggggug                                                   20


<210>  10104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10104
ccagcuagaa agggggugcc                                                   20


<210>  10105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10105
uguggcaccc ccuuucuagc                                                   20


<210>  10106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10106
cugcucuugu ggcacccccu                                                   20


<210>  10107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10107
uucauuuuuc aacaaauauu                                                   20


<210>  10108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10108
uggcaguuug gaauugugaa                                                   20


<210>  10109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10109
augccauauc uauaaaacug                                                   20


<210>  10110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10110
aacccaagau ccaaagcuaa                                                   20


<210>  10111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10111
gggccugugg ggaaaaugga                                                   20


<210>  10112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10112
ucccuguggg ucucagggcc                                                   20


<210>  10113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10113
auuuacauua uaaugcaaaa                                                   20


<210>  10114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10114
accccuccau uuacauuaua                                                   20


<210>  10115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10115
ugucaagggu ucccccaaac                                                   20


<210>  10116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10116
accuaagccu uaggaaagac                                                   20


<210>  10117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10117
agaaagaggg gcugagagcc                                                   20


<210>  10118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10118
uucuagaggc uccaccuaag                                                   20


<210>  10119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10119
gccccucuuu cuagaggcuc                                                   20


<210>  10120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10120
cagccccucu uucuagaggc                                                   20


<210>  10121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10121
uccccaggcu cucagccccu                                                   20


<210>  10122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10122
gaguucuucc cacuggggcu                                                   20


<210>  10123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10123
gaggaacugc uggugguugg                                                   20


<210>  10124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10124
gugugccugg aaacgcaguu                                                   20


<210>  10125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10125
uauccaauac ugugcagggg                                                   20


<210>  10126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10126
acggcauuac ucucccucca                                                   20


<210>  10127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10127
cccuccauuc uugcuuucag                                                   20


<210>  10128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10128
cuccauucuu gcuuucagau                                                   20


<210>  10129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10129
auucuugcuu ucagauucuc                                                   20


<210>  10130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10130
cuccuccugg caggggcacu                                                   20


<210>  10131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10131
uccuggcagg ggcacugggg                                                   20


<210>  10132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10132
uggcaggggc acuggggagg                                                   20


<210>  10133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10133
ccagugcccc ugccaggagg                                                   20


<210>  10134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10134
ugcccucccc agugccccug                                                   20


<210>  10135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10135
ccugcccucc ccagugcccc                                                   20


<210>  10136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10136
uucucuccug cccuccccag                                                   20


<210>  10137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10137
gguagaaggg auuugucccu                                                   20


<210>  10138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10138
cagguagaag ggauuugucc                                                   20


<210>  10139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10139
ccaguaggca auaacaagga                                                   20


<210>  10140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10140
uuguuauugc cuacugggga                                                   20


<210>  10141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10141
ccaauuuggg aaguaauguc                                                   20


<210>  10142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10142
acucuuuucc guuaccaaua                                                   20


<210>  10143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10143
uuuccguuac caauaaaaca                                                   20


<210>  10144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10144
gauuucugac aguucuuuuu                                                   20


<210>  10145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10145
guuaacuuaa aauagcccca                                                   20


<210>  10146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10146
aagagcuaca cucuacauaa                                                   20


<210>  10147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10147
uugagucuuc aguuuugaau                                                   20


<210>  10148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10148
acauaacugc acuauuaaug                                                   20


<210>  10149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10149
gucaacguau uuuccaagcc                                                   20


<210>  10150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10150
ccugccccuu agugucuuac                                                   20


<210>  10151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10151
aagcuuucaa cacucuguuu                                                   20


<210>  10152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10152
guuucuauga aggcaagggu                                                   20


<210>  10153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10153
aacccuugcc uucauagaaa                                                   20


<210>  10154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10154
cuccaacccu ugccuucaua                                                   20


<210>  10155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10155
ucauuuuacu gauuuauuug                                                   20


<210>  10156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10156
gcuacgccca guggcccagg                                                   20


<210>  10157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10157
cacuaaggua uccucccagc                                                   20


<210>  10158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10158
cuaagguauc cucccagcaa                                                   20


<210>  10159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10159
cagcaaugua gguguucaaa                                                   20


<210>  10160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10160
uggcguaaua cuugcucggc                                                   20


<210>  10161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10161
gccaaagaca uaguaacgcu                                                   20


<210>  10162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10162
aaaaugaaua ugugugcagc                                                   20


<210>  10163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10163
uuagccuucc aaguuguuug                                                   20


<210>  10164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10164
agugcuccuu agccuuccaa                                                   20


<210>  10165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10165
ccagcuccag ugcuccuuag                                                   20


<210>  10166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10166
ccaccccugg agagcaguca                                                   20


<210>  10167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10167
agggguggug agcacagggg                                                   20


<210>  10168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10168
ccaggggugg ugagcacagg                                                   20


<210>  10169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10169
gacugcucuc cagggguggu                                                   20


<210>  10170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10170
cugacugcuc uccaggggug                                                   20


<210>  10171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10171
gauguuuuaa aggaagccac                                                   20


<210>  10172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10172
agguggcuuc cuuuaaaaca                                                   20


<210>  10173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10173
ugguggcugc ccgaugcgcu                                                   20


<210>  10174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10174
gaaucauuca uuugggcuug                                                   20


<210>  10175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10175
gccacaagcc caaaugaaug                                                   20


<210>  10176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10176
cuuggccugu guccuugagc                                                   20


<210>  10177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10177
aggacacagg ccaagggagg                                                   20


<210>  10178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10178
cagguauaaa ggaucugucu                                                   20


<210>  10179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10179
gguauaaagg aucugucucc                                                   20


<210>  10180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10180
uucuaccugc cccugugcca                                                   20


<210>  10181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10181
ccucucaaau gagaaaggca                                                   20


<210>  10182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10182
caaaugagaa aggcagcuuu                                                   20


<210>  10183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10183
aaugagaaag gcagcuuuga                                                   20


<210>  10184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10184
uuugagaggc gagugugugu                                                   20


<210>  10185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10185
aagcugccuu ucucauuuga                                                   20


<210>  10186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10186
caaagcugcc uuucucauuu                                                   20


<210>  10187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10187
cucaaagcug ccuuucucau                                                   20


<210>  10188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10188
ccucccaacc cagaaccuau                                                   20


<210>  10189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10189
caacccagaa ccuaucacaa                                                   20


<210>  10190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10190
gcagagagua caugcucaac                                                   20


<210>  10191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10191
gcagagcauu gugauagguu                                                   20


<210>  10192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10192
cugcagagca uugugauagg                                                   20


<210>  10193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10193
acaaauccaa ugcuaaauug                                                   20


<210>  10194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10194
cuuuuuacaa uuuagcauug                                                   20


<210>  10195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10195
ccucucagcu cuaaauuauu                                                   20


<210>  10196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10196
ucucagcucu aaauuauuug                                                   20


<210>  10197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10197
cagcucuaaa uuauuugguc                                                   20


<210>  10198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10198
gcucuaaauu auuuggucua                                                   20


<210>  10199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10199
aaauuauuug gucuaaagaa                                                   20


<210>  10200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10200
auuuugcaua ucuaauugga                                                   20


<210>  10201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10201
aauuagauau gcaaaaugga                                                   20


<210>  10202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10202
uuuagugucu caaguaugag                                                   20


<210>  10203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10203
aguaugaguc accucugaug                                                   20


<210>  10204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10204
uacuugagac acuaaaagag                                                   20


<210>  10205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10205
gaugacggau aggagaacaa                                                   20


<210>  10206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10206
uauccgucau cagaggugac                                                   20


<210>  10207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10207
aaauggaugc caugugggug                                                   20


<210>  10208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10208
uccaaaugga ugccaugugg                                                   20


<210>  10209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10209
gugucuccuc caaauggaug                                                   20


<210>  10210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10210
uuucucugug ucuccuccaa                                                   20


<210>  10211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10211
uagacgucuc agagauuaac                                                   20


<210>  10212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10212
gagauuaaca uuuucucaaa                                                   20


<210>  10213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10213
gagacgucua agaggugaaa                                                   20


<210>  10214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10214
aaaaugaaca cacagagcaa                                                   20


<210>  10215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10215
guguguucau uuuugagaaa                                                   20


<210>  10216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10216
ucagcuguug cucugugugu                                                   20


<210>  10217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10217
gguuaccccc ugagaaaggc                                                   20


<210>  10218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10218
ggggguaacc agagguggug                                                   20


<210>  10219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10219
gccuuucuca ggggguaacc                                                   20


<210>  10220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10220
aauggugacu guucuggggg                                                   20


<210>  10221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10221
ucaaauggug acuguucugg                                                   20


<210>  10222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10222
ccucaaaugg ugacuguucu                                                   20


<210>  10223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10223
ugaucccuga accucuccuc                                                   20


<210>  10224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10224
ccaccccacu gaaauccaug                                                   20


<210>  10225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10225
caggcuagac uauccaugga                                                   20


<210>  10226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10226
ucuuugagcg gcucuucccc                                                   20


<210>  10227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10227
aagaugagaa agauaaagua                                                   20


<210>  10228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10228
uccccagagu caggaugacu                                                   20


<210>  10229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10229
ggggaagagc cgcucaaaga                                                   20


<210>  10230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10230
cacuagguuu cagguacauc                                                   20


<210>  10231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10231
cuagguuuca gguacauccc                                                   20


<210>  10232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10232
agucucugca gcugacacgg                                                   20


<210>  10233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10233
gcagcugaca cggcuccaag                                                   20


<210>  10234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10234
aagaugcuaa auaugagaca                                                   20


<210>  10235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10235
uauuuagcau cuuggagccg                                                   20


<210>  10236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10236
uugucucaua uuuagcaucu                                                   20


<210>  10237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10237
ugggacuaaa uuccuugucc                                                   20


<210>  10238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10238
uucuagugcc acuccuggga                                                   20


<210>  10239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10239
cucaggagcc aucugccggg                                                   20


<210>  10240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10240
ggagccaucu gccgggugcu                                                   20


<210>  10241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10241
ugagggagca gggacuccuu                                                   20


<210>  10242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10242
agaagcaccc ggcagauggc                                                   20


<210>  10243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10243
acgccccacu ugaggcuguc                                                   20


<210>  10244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10244
aguggggcgu ggaggcagca                                                   20


<210>  10245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10245
agccagccac cccaugggaa                                                   20


<210>  10246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10246
agccagaacu ccugcugcuu                                                   20


<210>  10247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10247
ugcugcuucu cucuuugugg                                                   20


<210>  10248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10248
cuuuguggag caaaucuuca                                                   20


<210>  10249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10249
uuguggagca aaucuucaug                                                   20


<210>  10250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10250
acaaagagag aagcagcagg                                                   20


<210>  10251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10251
cucuucugaa ucuucccacc                                                   20


<210>  10252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10252
cuucugaauc uucccacccu                                                   20


<210>  10253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10253
ucugaaucuu cccacccuuc                                                   20


<210>  10254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10254
ccacucacac gcuaaaguaa                                                   20


<210>  10255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10255
cacgcuaaag uaaaugaaua                                                   20


<210>  10256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10256
ucccugauca ggacugaaaa                                                   20


<210>  10257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10257
caucacacca cucucuggga                                                   20


<210>  10258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10258
cugggaaaau agaacugagu                                                   20


<210>  10259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10259
gggaaaauag aacugagucc                                                   20


<210>  10260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10260
guucuauuuu cccagagagu                                                   20


<210>  10261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10261
agcacugggc acagcugggu                                                   20


<210>  10262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10262
cucuucucaa caagccagag                                                   20


<210>  10263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10263
cuucucaaca agccagagau                                                   20


<210>  10264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10264
ucucaacaag ccagagauuc                                                   20


<210>  10265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10265
acaagccaga gauucucugc                                                   20


<210>  10266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10266
ggcuuguuga gaagagagag                                                   20


<210>  10267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10267
gccuuccaga caggcaccuc                                                   20


<210>  10268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10268
augaagagaa gcuguuccug                                                   20


<210>  10269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10269
ucauggaggu gccugucugg                                                   20


<210>  10270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10270
ccacaagcca ggaacagcuu                                                   20


<210>  10271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10271
cuggauugag ucgagaccug                                                   20


<210>  10272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10272
auccagggag uuuugcucac                                                   20


<210>  10273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10273
acucaaucca gggaguuuug                                                   20


<210>  10274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10274
agguucacag uccuaaaucc                                                   20


<210>  10275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10275
gagaaggaca gacuugaggg                                                   20


<210>  10276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10276
gaggauuuag gacugugaac                                                   20


<210>  10277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10277
agucuguccu ucucugagga                                                   20


<210>  10278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10278
gcccaugcca ggccaccugu                                                   20


<210>  10279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10279
gagccacacc agccaucucc                                                   20


<210>  10280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10280
gaguccuugu gugcugccuc                                                   20


<210>  10281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10281
uuguggacuu uccugagagc                                                   20


<210>  10282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10282
ggaaagucca caaggagaug                                                   20


<210>  10283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10283
caggaaaguc cacaaggaga                                                   20


<210>  10284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10284
aagcacucuc ugagaggcuu                                                   20


<210>  10285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10285
cugagaggcu uccaggcugg                                                   20


<210>  10286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10286
gagaggcuuc caggcuggag                                                   20


<210>  10287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10287
gagagugcuu ggagcacugc                                                   20


<210>  10288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10288
cagagagugc uuggagcacu                                                   20


<210>  10289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10289
agccuggaag ccucucagag                                                   20


<210>  10290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10290
gagaggcuuc caggcugggc                                                   20


<210>  10291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10291
gagcuccagc cuggaagccu                                                   20


<210>  10292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10292
cagagcucca gccuggaagc                                                   20


<210>  10293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10293
agccaugugg uggaaacugg                                                   20


<210>  10294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10294
gcacugcgau cccaccagug                                                   20


<210>  10295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10295
uggcucagca cugcgauccc                                                   20


<210>  10296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10296
aagucuuggg acugcccaga                                                   20


<210>  10297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10297
caccuguaau cucagcauuu                                                   20


<210>  10298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10298
gcauuuuggg aggccgaggc                                                   20


<210>  10299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10299
caaaaugcug agauuacagg                                                   20


<210>  10300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10300
gccucccaaa augcugagau                                                   20


<210>  10301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10301
ggugacccac acgccucggc                                                   20


<210>  10302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10302
ugaccucagg ugacccacac                                                   20


<210>  10303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10303
acuuaaaaaa aaaaaaaaaa                                                   20


<210>  10304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10304
caaguagcug ggauuauagg                                                   20


<210>  10305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10305
gccucccaag uagcugggau                                                   20


<210>  10306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10306
ugccucagcc ucccaaguag                                                   20


<210>  10307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10307
cagguucaag ugauucuccu                                                   20


<210>  10308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10308
gccucccagg uucaagugau                                                   20


<210>  10309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10309
uugcagccuc cgccucccag                                                   20


<210>  10310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10310
gcucauugca gccuccgccu                                                   20


<210>  10311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10311
agccugggcg acagagcgag                                                   20


<210>  10312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10312
gucgcccagg cuggagugca                                                   20


<210>  10313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10313
cucugucgcc caggcuggag                                                   20


<210>  10314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10314
aucucaaaaa aaaaaaaaaa                                                   20


<210>  10315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10315
aaaaaaaaaa aaaauuaaau                                                   20


<210>  10316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10316
cccacccaau uuaauuuuuu                                                   20


<210>  10317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10317
gauuuuuuuc cuaagaaacu                                                   20


<210>  10318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10318
uauggugccu uacccuuuca                                                   20


<210>  10319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10319
uaucaaugga auucacagcc                                                   20


<210>  10320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10320
cuuaucaaug gaauucacag                                                   20


<210>  10321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10321
aauaucaaag gucuugcaua                                                   20


<210>  10322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10322
uuucuuuuuu uuuuuuucuu                                                   20


<210>  10323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10323
cuuuucuuuu uuuuuuuuuc                                                   20


<210>  10324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10324
gucucucuuu ucuuuuuuuu                                                   20


<210>  10325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10325
cugucucucu uuucuuuuuu                                                   20


<210>  10326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10326
cucugucucu cuuuucuuuu                                                   20


<210>  10327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10327
cucucugucu cucuuuucuu                                                   20


<210>  10328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10328
cucucucugu cucucuuuuc                                                   20


<210>  10329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10329
cucucucucu gucucucuuu                                                   20


<210>  10330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10330
uccaagagcc agucaaagcc                                                   20


<210>  10331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10331
uggaugaguu uaaaagguga                                                   20


<210>  10332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10332
gccguucucc cucuggugag                                                   20


<210>  10333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10333
cucuggugag acaggcucua                                                   20


<210>  10334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10334
ggugagacag gcucuagcuu                                                   20


<210>  10335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10335
ccagagggag aacggcugag                                                   20


<210>  10336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10336
agcuuguuuc cagaaugcca                                                   20


<210>  10337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10337
aggggacccc cuaacuccaa                                                   20


<210>  10338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10338
aaaguguugc ccagaccuaa                                                   20


<210>  10339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10339
cccacgugcu ccuuccccaa                                                   20


<210>  10340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10340
uuccccaaca cuggcuucca                                                   20


<210>  10341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10341
ccuggaagcc aguguugggg                                                   20


<210>  10342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10342
cucaccugga agccaguguu                                                   20


<210>  10343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10343
gcuugcagau ucugucucgc                                                   20


<210>  10344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10344
ccagggagga agggggaaau                                                   20


<210>  10345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10345
cuggggagaa agugaaaaag                                                   20


<210>  10346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10346
caccuucccu ggacagggag                                                   20


<210>  10347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10347
cuguccaggg aaggugugag                                                   20


<210>  10348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10348
guucaaucaa gcagcgugag                                                   20


<210>  10349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10349
cgcugcuuga uugaacagag                                                   20


<210>  10350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10350
ugcccuccaa aagguuauaa                                                   20


<210>  10351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10351
aaaagguuau aauuugagga                                                   20


<210>  10352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10352
aauuauaacc uuuuggaggg                                                   20


<210>  10353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10353
ucaaauuaua accuuuugga                                                   20


<210>  10354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10354
uccucaaauu auaaccuuuu                                                   20


<210>  10355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10355
uggguguauu uucuccuccu                                                   20


<210>  10356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10356
gggauuaguu aaaaggggau                                                   20


<210>  10357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10357
uccaaagaaa gccaaguugc                                                   20


<210>  10358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10358
aaagaaagcc aaguugcuga                                                   20


<210>  10359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10359
gucagcaacu uggcuuucuu                                                   20


<210>  10360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10360
ccaggccauu uuucuaggua                                                   20


<210>  10361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10361
uucuaguggg cuggaccucc                                                   20


<210>  10362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10362
auaaauaucu gugggaccca                                                   20


<210>  10363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10363
cugaaacaca gcccagugcu                                                   20


<210>  10364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10364
gaaacacagc ccagugcuuu                                                   20


<210>  10365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10365
cugccugaaa gcacugggcu                                                   20


<210>  10366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10366
guccgccacc caccaccacu                                                   20


<210>  10367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10367
caucucuguc cgccacccac                                                   20


<210>  10368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10368
ugaucaccca acuuuccagc                                                   20


<210>  10369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10369
agucaggggc agaaaugggg                                                   20


<210>  10370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10370
caggccacuc aacccacugu                                                   20


<210>  10371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10371
acccacugug aggucuuacu                                                   20


<210>  10372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10372
caguggguug aguggccugg                                                   20


<210>  10373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10373
guaaucccca caguaagacc                                                   20


<210>  10374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10374
aauugacuug uucacuuccu                                                   20


<210>  10375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10375
gggcaccgcu gggccaacac                                                   20


<210>  10376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10376
guggguguug gcccagcggu                                                   20


<210>  10377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10377
aggguauuug uauuccagga                                                   20


<210>  10378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10378
ucucaccacu ucaauuaugu                                                   20


<210>  10379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10379
ccacuucaau uaugucuuca                                                   20


<210>  10380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10380
ugccagcuuu gggugcucua                                                   20


<210>  10381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10381
aagaugcuuu cccaugucug                                                   20


<210>  10382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10382
cugucaccuc uccucacccc                                                   20


<210>  10383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10383
ccucacccca gcacacagaa                                                   20


<210>  10384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10384
ucaccccagc acacagaaaa                                                   20


<210>  10385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10385
ccccagcaca cagaaaagau                                                   20


<210>  10386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10386
uauuauuaaa acacagguuu                                                   20


<210>  10387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10387
aaaaagacuu ggcucugcug                                                   20


<210>  10388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10388
gcuggcucac agggaaucug                                                   20


<210>  10389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10389
cagggaaucu gggcuccgcu                                                   20


<210>  10390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10390
gcucuuccaa aaccuuuguu                                                   20


<210>  10391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10391
uccaaaaccu uuguucucca                                                   20


<210>  10392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10392
agaugucagu gcaaaguuau                                                   20


<210>  10393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10393
cccccugagc uaacuuaccg                                                   20


<210>  10394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10394
cccugagcua acuuaccgag                                                   20


<210>  10395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10395
gggggagagc uguucauaac                                                   20


<210>  10396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10396
guaaguuagc ucagggggag                                                   20


<210>  10397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10397
cuuacugcuc gguaaguuag                                                   20


<210>  10398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10398
cuauauuucu cagccuccau                                                   20


<210>  10399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10399
gccuccauga agucgucacu                                                   20


<210>  10400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10400
augaagucgu cacugggaga                                                   20


<210>  10401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10401
cagugacgac uucauggagg                                                   20


<210>  10402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10402
cccagugacg acuucaugga                                                   20


<210>  10403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10403
ucucccagug acgacuucau                                                   20


<210>  10404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10404
uggcuccucu cccagugacg                                                   20


<210>  10405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10405
cucuuggcuc cucucccagu                                                   20


<210>  10406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10406
uaaggugccc ccucccucuu                                                   20


<210>  10407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10407
ccgucauccg gggaagugga                                                   20


<210>  10408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10408
acuuccccgg augacgguga                                                   20


<210>  10409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10409
ccacuucccc ggaugacggu                                                   20


<210>  10410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10410
ugucaggagu ggagagcuaa                                                   20


<210>  10411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10411
ugacacgagu ucccugacuu                                                   20


<210>  10412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10412
acuccugaca cgaguucccu                                                   20


<210>  10413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10413
ccacuccuga cacgaguucc                                                   20


<210>  10414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10414
auauggacaa ggacagagag                                                   20


<210>  10415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10415
guccuugucc auauugagcu                                                   20


<210>  10416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10416
cuguccuugu ccauauugag                                                   20


<210>  10417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10417
caucccaggu gccccucucu                                                   20


<210>  10418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10418
caguuguccu gaugccacau                                                   20


<210>  10419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10419
aagauggcug acaaagaucu                                                   20


<210>  10420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10420
gcuugguguc cacuaggaau                                                   20


<210>  10421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10421
ugcucagcuu gguguccacu                                                   20


<210>  10422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10422
uauguccugc uugcuuuuuu                                                   20


<210>  10423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10423
guaguuauca gacuaauguu                                                   20


<210>  10424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10424
aacauuaguc ugauaacuac                                                   20


<210>  10425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10425
uuuacucaaa cauuagucug                                                   20


<210>  10426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10426
uuagaaucug cugguuuucc                                                   20


<210>  10427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10427
cuuuagaauc ugcugguuuu                                                   20


<210>  10428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10428
uggaucuauu aucuuguaac                                                   20


<210>  10429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10429
uuccugaacc ugaacucaug                                                   20


<210>  10430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10430
gccacuucuu cuuccuaaau                                                   20


<210>  10431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10431
ucaccagcuu ugggcugaaa                                                   20


<210>  10432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10432
ggaaugaaga ggaaaugggu                                                   20


<210>  10433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10433
ucauuccaga gacgacaaag                                                   20


<210>  10434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10434
aucgcaggaa auccuuccuu                                                   20


<210>  10435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10435
caaucgcagg aaauccuucc                                                   20


<210>  10436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10436
ccacccuagu ucuauuuuua                                                   20


<210>  10437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10437
uccucaccac ccuaguucua                                                   20


<210>  10438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10438
agaauuggcc agcccaaccu                                                   20


<210>  10439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10439
ggggcagaug gcccuccaga                                                   20


<210>  10440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10440
caggggcaga uggcccucca                                                   20


<210>  10441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10441
aucuacucca uuaucuccag                                                   20


<210>  10442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10442
auuaucucca guuaucugaa                                                   20


<210>  10443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10443
aguuaucuga auaaaaaagc                                                   20


<210>  10444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10444
caaagugugg cccuucuggg                                                   20


<210>  10445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10445
gcccuuuuuc ggggcugguc                                                   20


<210>  10446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10446
gcaacagcac aggugauugg                                                   20


<210>  10447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10447
ccagguuagc acugccacaa                                                   20


<210>  10448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10448
ucaacaaagc uccaguuaag                                                   20


<210>  10449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10449
aguuaagaaa agcauuccag                                                   20


<210>  10450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10450
gcaaagcaca ugcgggccac                                                   20


<210>  10451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10451
ggcuccugcu ggccauggag                                                   20


<210>  10452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10452
ugcuggccau ggagaggcca                                                   20


<210>  10453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10453
auggccagca ggagccagag                                                   20


<210>  10454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10454
ccauggccag caggagccag                                                   20


<210>  10455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10455
gggccaaguc uaccacugcc                                                   20


<210>  10456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10456
ggcacucacu ccccucuuag                                                   20


<210>  10457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10457
cuccccucuu agccucaacc                                                   20


<210>  10458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10458
ccucuuagcc ucaaccuuuc                                                   20


<210>  10459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10459
uagccucaac cuuucucauc                                                   20


<210>  10460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10460
accuuucuca ucuguaaaau                                                   20


<210>  10461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10461
ucuguaaaau gacaggguua                                                   20


<210>  10462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10462
auaaguauuc acuuuggcuu                                                   20


<210>  10463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10463
aagagcugug cuuucuucua                                                   20


<210>  10464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10464
uugagcauag auaguuuccu                                                   20


<210>  10465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10465
gaaacucuug ucgacuagag                                                   20


<210>  10466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10466
ugucgacuag aggaacaaga                                                   20


<210>  10467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10467
agucgacaag aguuucugag                                                   20


<210>  10468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10468
aaaacccaau uuuaggggag                                                   20


<210>  10469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10469
ccuaaaauug gguuuuagag                                                   20


<210>  10470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10470
uccccuaaaa uuggguuuua                                                   20


<210>  10471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10471
ccuccccuaa aauuggguuu                                                   20


<210>  10472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10472
ggccuucaag uaauuaauuu                                                   20


<210>  10473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10473
gaaauuugga aggccacaga                                                   20


<210>  10474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10474
guggccuucc aaauuucuga                                                   20


<210>  10475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10475
uagcuucaag caaucuuccc                                                   20


<210>  10476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10476
acaaaaagcu uaauaaauaa                                                   20


<210>  10477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10477
gcaauuauuu uauuuuauuu                                                   20


<210>  10478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10478
uucccucugu caacaucugc                                                   20


<210>  10479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10479
gucaacaucu gcugagcucu                                                   20


<210>  10480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10480
gcagauguug acagagggaa                                                   20


<210>  10481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10481
cauaauacau aaaacaucau                                                   20


<210>  10482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10482
uaauacauaa aacaucauag                                                   20


<210>  10483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10483
uuuaucuaug auguuuuaug                                                   20


<210>  10484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10484
gagaauuugg cuacuacuua                                                   20


<210>  10485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10485
gagucugcuu caugacaggc                                                   20


<210>  10486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10486
aucgcagaca uuuuaaaacu                                                   20


<210>  10487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10487
ccugcauuua aauaugaaua                                                   20


<210>  10488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10488
uuauucauau uuaaaugcag                                                   20


<210>  10489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10489
cucuuuauuc auauuuaaau                                                   20


<210>  10490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10490
caugugccau uuuuaccugg                                                   20


<210>  10491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10491
agaucugaga aucaccacac                                                   20


<210>  10492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10492
gaucuagagc aaugcuuccu                                                   20


<210>  10493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10493
gguguguggu gauucucaga                                                   20


<210>  10494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10494
cuggugugug gugauucuca                                                   20


<210>  10495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10495
caugcccucu cuggugugug                                                   20


<210>  10496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10496
gcuggguuug ugugucaccu                                                   20


<210>  10497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10497
acguucucug cuggguuugu                                                   20


<210>  10498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10498
uucucaacgu ucucugcugg                                                   20


<210>  10499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10499
uaaaacucuu ucucaacguu                                                   20


<210>  10500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10500
ucaucagagu ucacuuaaaa                                                   20


<210>  10501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10501
gaugaugagu aggcucuuaa                                                   20


<210>  10502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10502
ucaauuacug uucaaguuca                                                   20


<210>  10503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10503
augggcaaag aucaagaggc                                                   20


<210>  10504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10504
ugaucuuugc ccaucgagca                                                   20


<210>  10505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10505
cuacaaucca cagcaaaagg                                                   20


<210>  10506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10506
uuuugcugug gauuguaggg                                                   20


<210>  10507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10507
ccuuuugcug uggauuguag                                                   20


<210>  10508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10508
uuaaaagaag gaacucuccu                                                   20


<210>  10509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10509
caacucuuga gagaaaaugg                                                   20


<210>  10510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10510
acucuugaga gaaaauggac                                                   20


<210>  10511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10511
ugagagaaaa uggacagaag                                                   20


<210>  10512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10512
agaguugaga gaugugugcc                                                   20


<210>  10513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10513
caagaguuga gagaugugug                                                   20


<210>  10514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10514
cuguuuccug cugguaucag                                                   20


<210>  10515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10515
gguagguacu accaaaccaa                                                   20


<210>  10516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10516
caaguacacc aggaaccccu                                                   20


<210>  10517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10517
gguucccuuu cuugccccgc                                                   20


<210>  10518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10518
gucuaugggu aucaacaccu                                                   20


<210>  10519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10519
auauugagag acauaaaaca                                                   20


<210>  10520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10520
auauggaggu uauagaauca                                                   20


<210>  10521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10521
caauauggag guuauagaau                                                   20


<210>  10522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10522
aggcagcuga aagucaguac                                                   20


<210>  10523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10523
uuacagguua uagacacauu                                                   20


<210>  10524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10524
ccuuacaggu uauagacaca                                                   20


<210>  10525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10525
ugcugcagag aaaaaauaag                                                   20


<210>  10526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10526
gcagcaugag ugcagucacc                                                   20


<210>  10527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10527
cuugccugcc ugccugccug                                                   20


<210>  10528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10528
uguaaggaaa gaaggcaggc                                                   20


<210>  10529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10529
ugaaaucuga cgugcuuugc                                                   20


<210>  10530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10530
aguggucaac uuacugcugu                                                   20


<210>  10531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10531
cuuucuccag uggucaacuu                                                   20


<210>  10532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10532
gaaaucuaca agauuccagu                                                   20


<210>  10533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10533
cagcugcaug ugucagaaca                                                   20


<210>  10534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10534
cagucacauc cuguauucuc                                                   20


<210>  10535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10535
uaaauuacuc caaugacaaa                                                   20


<210>  10536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10536
aaugacaaag aaaacucagu                                                   20


<210>  10537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10537
gugaagacaa agagaucguu                                                   20


<210>  10538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10538
uugucuucac ugaguuuucu                                                   20


<210>  10539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10539
ggaauucaug gcuaugcuug                                                   20


<210>  10540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10540
cuagacuugg aguguuaaaa                                                   20


<210>  10541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10541
agacuuggag uguuaaaagu                                                   20


<210>  10542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10542
aagucuagag agaauuaucc                                                   20


<210>  10543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10543
ccucucucug gcaggagaau                                                   20


<210>  10544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10544
cucuggcagg agaaucaugu                                                   20


<210>  10545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10545
cuggcaggag aaucauguca                                                   20


<210>  10546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10546
ggcaggagaa ucaugucacu                                                   20


<210>  10547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10547
ugccagagag aggggagaau                                                   20


<210>  10548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10548
ucaaauaauu cggccuaaau                                                   20


<210>  10549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10549
ugcauaaaua auuuugcaau                                                   20


<210>  10550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10550
aaaguuccca ggcaaauggg                                                   20


<210>  10551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10551
uuaauuuuca cccuuacaau                                                   20


<210>  10552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10552
ucugcagguu uuguuuauuu                                                   20


<210>  10553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10553
aaauaaacaa aaccugcaga                                                   20


<210>  10554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10554
ugucuugaaa aaaaaaguga                                                   20


<210>  10555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10555
cugauuagua augcauuaug                                                   20


<210>  10556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10556
agaauuuaua cucacugauu                                                   20


<210>  10557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10557
gacuccagaa uuuauacuca                                                   20


<210>  10558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10558
uuacuuuuau aaucuagauu                                                   20


<210>  10559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10559
uucuuauaaa cggaaugcga                                                   20


<210>  10560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10560
cagaguuuuc ugaggaaaau                                                   20


<210>  10561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10561
gugaggauaa uuucuccuuc                                                   20


<210>  10562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10562
gaaaacucug ugaggauaau                                                   20


<210>  10563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10563
gacucaacac uaugaggcau                                                   20


<210>  10564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10564
acacuaugag gcauaagguc                                                   20


<210>  10565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10565
uaguguugag ucagagcaaa                                                   20


<210>  10566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10566
uuggugcuuc ugugguugug                                                   20


<210>  10567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10567
ccuuggugcu ucugugguug                                                   20


<210>  10568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10568
uuuugaugca aauaucuuca                                                   20


<210>  10569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10569
aguggguucc caccgguguu                                                   20


<210>  10570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10570
guacacaacc uuugucaacc                                                   20


<210>  10571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10571
auuucauccc uuuccaaaaa                                                   20


<210>  10572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10572
ccauuucauc ccuuuccaaa                                                   20


<210>  10573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10573
cacacacaca cacacacaca                                                   20


<210>  10574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10574
cacaaauccu ugagggugcc                                                   20


<210>  10575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10575
aggauuugug ugagugugug                                                   20


<210>  10576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10576
cagauaacug agugacacuu                                                   20


<210>  10577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10577
gauaacugag ugacacuugc                                                   20


<210>  10578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10578
guuaucugag aguggcgcuu                                                   20


<210>  10579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10579
gugugaagcg agagagagcg                                                   20


<210>  10580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10580
cuucacacag aggcuauuau                                                   20


<210>  10581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10581
cgcuucacac agaggcuauu                                                   20


<210>  10582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10582
cucgcuucac acagaggcua                                                   20


<210>  10583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10583
cucucgcuuc acacagaggc                                                   20


<210>  10584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10584
gguuuuacaa aauguccgcu                                                   20


<210>  10585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10585
gcuuccaggc agcagauacg                                                   20


<210>  10586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10586
gccguaucug cugccuggaa                                                   20


<210>  10587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10587
ucucugccgu aucugcugcc                                                   20


<210>  10588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10588
ccugugacgg gcugcacgaa                                                   20


<210>  10589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10589
gcaauugcca cucugcuccc                                                   20


<210>  10590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10590
gcucccuuuc aucuuccauc                                                   20


<210>  10591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10591
cuuucaucuu ccaucuugug                                                   20


<210>  10592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10592
cuuaaaggga aggcugcuua                                                   20


<210>  10593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10593
gaaagaaggg gacaaagaac                                                   20


<210>  10594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10594
cagaaagaag gggacaaaga                                                   20


<210>  10595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10595
ucucaggcaa aucaucuuuc                                                   20


<210>  10596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10596
caggcaaauc aucuuucucu                                                   20


<210>  10597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10597
ggcaaaucau cuuucucuaa                                                   20


<210>  10598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10598
aauagccagg gcucaaaugg                                                   20


<210>  10599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10599
aauggccaaa gaaagguccc                                                   20


<210>  10600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10600
cguggcuggu aguguuauga                                                   20


<210>  10601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10601
ccacgaggca cagaggcacc                                                   20


<210>  10602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10602
uggugagggu caggaagaag                                                   20


<210>  10603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10603
gugccucgug gugaggguca                                                   20


<210>  10604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10604
agcaaacgcc acaucugacu                                                   20


<210>  10605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10605
gccucaugca cugaaaaaga                                                   20


<210>  10606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10606
ugcacugaaa aagacaaggg                                                   20


<210>  10607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10607
guucuuccag gagaaugggg                                                   20


<210>  10608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10608
uggaagaaca gagaucccuu                                                   20


<210>  10609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10609
agucuuguau cugggaaguu                                                   20


<210>  10610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10610
cagguacuuu cuugcccaua                                                   20


<210>  10611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10611
gagccaaacc cuuggugaag                                                   20


<210>  10612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10612
gagguagcaa ggggacaagu                                                   20


<210>  10613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10613
ccaccaguca ggcaauaccu                                                   20


<210>  10614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10614
accagucagg caauaccuuu                                                   20


<210>  10615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10615
aauacuacaa aaguagagag                                                   20


<210>  10616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10616
acuuuuguag uauuugagau                                                   20


<210>  10617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10617
cuacuuuugu aguauuugag                                                   20


<210>  10618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10618
aaccaccaca gcucacaguc                                                   20


<210>  10619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10619
cagucauucu ugucuucugu                                                   20


<210>  10620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10620
cuagcccauu uuauuauuua                                                   20


<210>  10621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10621
guauguauuu uuuaaacaua                                                   20


<210>  10622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10622
uuuuuuuucu uuuaaauaca                                                   20


<210>  10623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10623
ccuauuuggu aauacgggac                                                   20


<210>  10624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10624
gaaauacuuc uuuccaucug                                                   20


<210>  10625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10625
aaaacaugac ccagauggaa                                                   20


<210>  10626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10626
cuggaaggga uccuccaaaa                                                   20


<210>  10627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10627
gaagcuuuuc uuggcagcuu                                                   20


<210>  10628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10628
cuaaaaaggg ccuuguguaa                                                   20


<210>  10629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10629
aaaaagggcc uuguguaaag                                                   20


<210>  10630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10630
ugccccuugc aguccuuugc                                                   20


<210>  10631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10631
gagagucucu gugacagucc                                                   20


<210>  10632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10632
gagggugcau ucagcccuga                                                   20


<210>  10633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10633
cagagggugc auucagcccu                                                   20


<210>  10634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10634
gugacagucc ucccacaucg                                                   20


<210>  10635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10635
cacaucgacu gccccacagg                                                   20


<210>  10636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10636
gggccugugg ggcagucgau                                                   20


<210>  10637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10637
cucacucccc accauguggc                                                   20


<210>  10638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10638
cuccccacca uguggcccau                                                   20


<210>  10639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10639
ccaccaugug gcccaucacc                                                   20


<210>  10640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10640
caguguucag aacuggaauu                                                   20


<210>  10641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10641
uggacgguuc ugcacagaau                                                   20


<210>  10642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10642
gugaaugaau ucugugcaga                                                   20


<210>  10643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10643
ugccugcaga accuugaccu                                                   20


<210>  10644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10644
aaaagcauuu ugaccuuauc                                                   20


<210>  10645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10645
cugucucuaa aagcauuuug                                                   20


<210>  10646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10646
ggaacuagug cuccagagag                                                   20


<210>  10647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10647
agagagacac agagauugaa                                                   20


<210>  10648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10648
ggagcacuag uuccagaggc                                                   20


<210>  10649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10649
cuggagcacu aguuccagag                                                   20


<210>  10650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10650
gugucucucu ggagcacuag                                                   20


<210>  10651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10651
guagacucug uggguaaaag                                                   20


<210>  10652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10652
guggguaaaa gcuuguugga                                                   20


<210>  10653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10653
gcaucugguu aaauggacuu                                                   20


<210>  10654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10654
uggcagaacc guaaagaagg                                                   20


<210>  10655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10655
cuucuuuacg guucugccau                                                   20


<210>  10656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10656
agguugcaac acguguugcc                                                   20


<210>  10657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10657
acucagggga ggcacaaagg                                                   20


<210>  10658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10658
ggggaggcac aaaggacagc                                                   20


<210>  10659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10659
ccugaguuga gaagacuggu                                                   20


<210>  10660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10660
uaaauuugcc acuaugaucc                                                   20


<210>  10661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10661
auccagcgcu augugaacaa                                                   20


<210>  10662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10662
auacuauuua ucugaaaguc                                                   20


<210>  10663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10663
cucucucccu uucuacacac                                                   20


<210>  10664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10664
cucucccuuu cuacacacac                                                   20


<210>  10665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10665
cucccuuucu acacacacac                                                   20


<210>  10666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10666
cccuuucuac acacacacag                                                   20


<210>  10667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10667
cuuucuacac acacacaggc                                                   20


<210>  10668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10668
uuuugaaaaa aaaaaaaauc                                                   20


<210>  10669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10669
aguaagcaaa aucauucauu                                                   20


<210>  10670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10670
aguuuugccu ggcaaugaau                                                   20


<210>  10671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10671
uaugauuucu aaauguauuu                                                   20


<210>  10672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10672
ugugugcucg uaugauuucu                                                   20


<210>  10673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10673
aucaaguaaa ugaaucacca                                                   20


<210>  10674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10674
uauuuggcuu aaauaaauua                                                   20


<210>  10675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10675
ggcugaaguu uaagauggga                                                   20


<210>  10676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10676
ccauuaucag gggugcuuua                                                   20


<210>  10677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10677
auuaucaggg gugcuuuauu                                                   20


<210>  10678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10678
aacaauaaag caccccugau                                                   20


<210>  10679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10679
caaacaauaa agcaccccug                                                   20


<210>  10680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10680
ggaccacagg aacuagugug                                                   20


<210>  10681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10681
aguuuucaca cuaguuccug                                                   20


<210>  10682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10682
cauuucgcaa acaaaauaug                                                   20


<210>  10683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10683
cuaaugcggu cagcuguguc                                                   20


<210>  10684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10684
uauuguguug ugcaaaugua                                                   20


<210>  10685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10685
cccaccucuu auuguguugu                                                   20


<210>  10686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10686
ucucccccac cucuuauugu                                                   20


<210>  10687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10687
cuucuccccc accucuuauu                                                   20


<210>  10688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10688
ggcaugaaug uuaucaugcu                                                   20


<210>  10689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10689
acuuuccccu uccauuauua                                                   20


<210>  10690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10690
ggggggcugc cauucauucg                                                   20


<210>  10691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10691
gguaacaaaa uaaaaucuua                                                   20


<210>  10692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10692
ucuaucucug guaacaaaau                                                   20


<210>  10693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10693
guaagggcac ugguaaucag                                                   20


<210>  10694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10694
uuaauuuaua auguuuuggg                                                   20


<210>  10695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10695
agagugccug uguccuacaa                                                   20


<210>  10696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10696
ugagaucuau agcuucaaua                                                   20


<210>  10697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10697
gagcacaugg gauaauaaaa                                                   20


<210>  10698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10698
gaguaagggg caaaugaauc                                                   20


<210>  10699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10699
uucaaugcca cauauaaaug                                                   20


<210>  10700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10700
auuuaugcug ucuucaacac                                                   20


<210>  10701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10701
guuaguguug aagacagcau                                                   20


<210>  10702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10702
cucuguuagu guugaagaca                                                   20


<210>  10703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10703
cccucuguua guguugaaga                                                   20


<210>  10704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10704
agggacucag cauauguagg                                                   20


<210>  10705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10705
gcauauguag gcuaugucca                                                   20


<210>  10706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10706
guauggacau agccuacaua                                                   20


<210>  10707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10707
caaaagcugg uuucucugua                                                   20


<210>  10708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10708
ucccaaaagc ugguuucucu                                                   20


<210>  10709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10709
uuccuccucc caaaagcugg                                                   20


<210>  10710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10710
aaguuugcuu uuuugggcaa                                                   20


<210>  10711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10711
aaagaaugua auguguauuu                                                   20


<210>  10712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10712
aucuuuuaau uguugcaagc                                                   20


<210>  10713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10713
accauagcuu ccaucuuuga                                                   20


<210>  10714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10714
aagauggaag cuauggugga                                                   20


<210>  10715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10715
ccugcaaaga cagcagaaua                                                   20


<210>  10716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10716
cugcuauuuu uuggaaucua                                                   20


<210>  10717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10717
aaguccccau gauguucuag                                                   20


<210>  10718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10718
cuucaccugu uagcauuugu                                                   20


<210>  10719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10719
cagcaugaua caauaagggu                                                   20


<210>  10720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10720
cuguuaacac uaaaagucaa                                                   20


<210>  10721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10721
guuaacacua aaagucaaag                                                   20


<210>  10722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10722
ccccaaacca gucuugguaa                                                   20


<210>  10723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10723
auggcuuuca cagaagggua                                                   20


<210>  10724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10724
caauuggaag gucuucauac                                                   20


<210>  10725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10725
auuggaaggu cuucauacua                                                   20


<210>  10726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10726
accagaaaau aacaguaucu                                                   20


<210>  10727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10727
cacccugaac uucugcaaaa                                                   20


<210>  10728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10728
cccugaacuu cugcaaaauc                                                   20


<210>  10729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10729
uucuucccca aaagauuuuu                                                   20


<210>  10730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10730
auacaucuaa ucaauaaaua                                                   20


<210>  10731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10731
uaugcaucuc cccccacccc                                                   20


<210>  10732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10732
ccccaccccc ucugcaucgc                                                   20


<210>  10733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10733
gcaucgcaga cagcagugcu                                                   20


<210>  10734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10734
aaaggguccg caaaauaaaa                                                   20


<210>  10735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10735
uuugucccug augcaaauua                                                   20


<210>  10736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10736
gauuuuaauc ugcagcgcau                                                   20


<210>  10737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10737
ucucggauua ugaaacaaua                                                   20


<210>  10738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10738
cggauuauga aacaauacca                                                   20


<210>  10739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10739
gauuaugaaa caauaccaag                                                   20


<210>  10740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10740
ugacauagac acacugcacu                                                   20


<210>  10741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10741
cugcgcuaau cucugcccag                                                   20


<210>  10742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10742
gcccagccaa cgcauucuua                                                   20


<210>  10743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10743
uccaacagcc ucuuaaccag                                                   20


<210>  10744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10744
uaaccagucc acugccccuc                                                   20


<210>  10745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10745
gaggucuccc cgguuauggc                                                   20


<210>  10746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10746
gaggggcagu ggacugguua                                                   20


<210>  10747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10747
ccgguuaugg cuuugcuaaa                                                   20


<210>  10748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10748
caccauucga uauuuauugu                                                   20


<210>  10749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10749
ccauucgaua uuuauuguag                                                   20


<210>  10750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10750
ugggacauca aauuugugcu                                                   20


<210>  10751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10751
gaugauggcc uuuuguuucu                                                   20


<210>  10752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10752
ucccuugaaa aucagugaaa                                                   20


<210>  10753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10753
cacccccuag uuuuccuucu                                                   20


<210>  10754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10754
cucgcacccc cuaguuuucc                                                   20


<210>  10755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10755
uagacugaaa ugauaaagcu                                                   20


<210>  10756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10756
uaguuuuauu ugcugggucu                                                   20


<210>  10757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10757
uccaggguga caagggagaa                                                   20


<210>  10758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10758
cuugucaccc uggaagagaa                                                   20


<210>  10759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10759
ugacccaagg guauguagag                                                   20


<210>  10760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10760
acauacccuu gggucaagag                                                   20


<210>  10761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10761
ucauugucuc uacauacccu                                                   20


<210>  10762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10762
uggcccucuu cauugucucu                                                   20


<210>  10763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10763
ccccuucucu uggcccucuu                                                   20


<210>  10764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10764
auugaggacg uccaugcccc                                                   20


<210>  10765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10765
auggagguca ugcaagcccu                                                   20


<210>  10766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10766
gucccggggc auggacgucc                                                   20


<210>  10767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10767
aaagcuucac uuuuacuucg                                                   20


<210>  10768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10768
ugacccacau ggauucucag                                                   20


<210>  10769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10769
gcagccaccu ccaucccacc                                                   20


<210>  10770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10770
aucccaccuc aaacucagaa                                                   20


<210>  10771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10771
aacucagaag acaaccugga                                                   20


<210>  10772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10772
gaagacaacc uggaugugac                                                   20


<210>  10773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10773
cuugguucua gcagaaggac                                                   20


<210>  10774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10774
cuugguaagu ccuucugcua                                                   20


<210>  10775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10775
gcucacuugg uaaguccuuc                                                   20


<210>  10776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10776
cauccgauac ucgccagugc                                                   20


<210>  10777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10777
ccagugcuga ggccaacucu                                                   20


<210>  10778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10778
gcacuggcga guaucggaug                                                   20


<210>  10779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10779
uccacuccuc ccacggggcc                                                   20


<210>  10780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10780
ucccacgggg ccuccgcaug                                                   20


<210>  10781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10781
cacggggccu ccgcaugaag                                                   20


<210>  10782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10782
gcaugaagua ggcgcuucuc                                                   20


<210>  10783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10783
acuaccaaau gauucugaaa                                                   20


<210>  10784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10784
caguggaggu cuauguuagc                                                   20


<210>  10785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10785
guggaggucu auguuagccu                                                   20


<210>  10786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10786
acugagagaa uuucagaauc                                                   20


<210>  10787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10787
auccuuucaa auuggccagg                                                   20


<210>  10788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10788
ggucuugcuu cagcaaauau                                                   20


<210>  10789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10789
acaggcugcc cugacgcuau                                                   20


<210>  10790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10790
cagucacucc acaggcugcc                                                   20


<210>  10791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10791
cccagucacu ccacaggcug                                                   20


<210>  10792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10792
ggggaagcca caugcggauc                                                   20


<210>  10793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10793
auaugauccg cauguggcuu                                                   20


<210>  10794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10794
aguuuccagc augccuuccg                                                   20


<210>  10795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10795
ucgaagcaga uuaugacccc                                                   20


<210>  10796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10796
aagcagauua ugacccccca                                                   20


<210>  10797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10797
cucacacuca gucucucccu                                                   20


<210>  10798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10798
cacucagucu cucccucccu                                                   20


<210>  10799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10799
gucucucccu cccuguauaa                                                   20


<210>  10800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10800
cccucccugu auaauucuga                                                   20


<210>  10801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10801
cucccuguau aauucugauu                                                   20


<210>  10802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10802
cuguauaauu cugauucucc                                                   20


<210>  10803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10803
ccagccuuug aagguacgau                                                   20


<210>  10804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10804
gaucguaccu ucaaaggcug                                                   20


<210>  10805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10805
guggcauuua cuucucggau                                                   20


<210>  10806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10806
ccacuucuua aaaguccgag                                                   20


<210>  10807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10807
gacuuuuaag aaguggugag                                                   20


<210>  10808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10808
uucagcccac ugcagucucc                                                   20


<210>  10809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10809
ugaccaagcc acacacaaac                                                   20


<210>  10810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10810
ucccucuguu ucucaggacc                                                   20


<210>  10811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10811
cucuguuucu caggacccuc                                                   20


<210>  10812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10812
guuucucagg acccucacuu                                                   20


<210>  10813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10813
ggacccucac uugauuucag                                                   20


<210>  10814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10814
cuugauuuca ggcucauucu                                                   20


<210>  10815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10815
uucuggacag auggggaaau                                                   20


<210>  10816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10816
gugcuccuuc aauaugccca                                                   20


<210>  10817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10817
uucaauaugc ccagaacugg                                                   20


<210>  10818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10818
aguucugggc auauugaagg                                                   20


<210>  10819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10819
uucccagaag auugaaaaac                                                   20


<210>  10820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10820
cauggguucu guggucaagu                                                   20


<210>  10821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10821
ggugcuggac aguugucccu                                                   20


<210>  10822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10822
ucaguacguu ugcagcuuuc                                                   20


<210>  10823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10823
gcuaccucuu caguacguuu                                                   20


<210>  10824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10824
gggaagucau uuaacccuug                                                   20


<210>  10825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10825
ucuaccaaau gaggcuaaug                                                   20


<210>  10826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10826
accaaaugag gcuaauggga                                                   20


<210>  10827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10827
uuugguagag gaggaaauug                                                   20


<210>  10828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10828
cauuagccuc auuugguaga                                                   20


<210>  10829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10829
gaaaggaaac acucccauua                                                   20


<210>  10830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10830
agaauugcug uugucauuau                                                   20


<210>  10831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10831
gggggcugca ccuccagaau                                                   20


<210>  10832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10832
cuccgggggc ugcaccucca                                                   20


<210>  10833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10833
uuuacuucuc acauggacuc                                                   20


<210>  10834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10834
cauggacucu augagguaag                                                   20


<210>  10835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10835
augagguaag ggaccuugag                                                   20


<210>  10836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10836
uagaguccau gugagaagua                                                   20


<210>  10837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10837
aggucccuua ccucauagag                                                   20


<210>  10838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10838
auuucacaga gaggugaaau                                                   20


<210>  10839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10839
gugaaaugga gauaacucaa                                                   20


<210>  10840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10840
cugugaaaug gagauaacuc                                                   20


<210>  10841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10841
gacucuccca accagcuagc                                                   20


<210>  10842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10842
cccaaccagc uagcaguaac                                                   20


<210>  10843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10843
caaccagcua gcaguaacau                                                   20


<210>  10844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10844
ggguucagau uucuauguua                                                   20


<210>  10845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10845
cguaaggcaa cacacgucua                                                   20


<210>  10846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10846
uaaggcaaca cacgucuaug                                                   20


<210>  10847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10847
ccauagacgu guguugccuu                                                   20


<210>  10848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10848
ccccauagac guguguugcc                                                   20


<210>  10849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10849
cacccacgag ggagcugcca                                                   20


<210>  10850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10850
ugggugggag uccccucucc                                                   20


<210>  10851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10851
cucgugggug ggaguccccu                                                   20


<210>  10852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10852
uuauguuucu gguggcagcu                                                   20


<210>  10853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10853
gggucucauu auguuucugg                                                   20


<210>  10854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10854
uuagaccccc accugcccug                                                   20


<210>  10855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10855
ucucucaucc caaccugcuc                                                   20


<210>  10856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10856
caucccaacc ugcucacccc                                                   20


<210>  10857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10857
ucccaaccug cucaccccau                                                   20


<210>  10858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10858
ccccauaaug ggggaacuac                                                   20


<210>  10859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10859
aaguaguucc cccauuaugg                                                   20


<210>  10860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10860
uggggucuca aaguaguucc                                                   20


<210>  10861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10861
uggcuuggaa cugugugcuc                                                   20


<210>  10862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10862
uuacuauuac gguuaugacu                                                   20


<210>  10863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10863
gugcugggca caugguaaaa                                                   20


<210>  10864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10864
cauaggaugc ucaaaggccc                                                   20


<210>  10865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10865
uaggaugcuc aaaggcccua                                                   20


<210>  10866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10866
aaggcccuau gaggcaagcc                                                   20


<210>  10867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10867
uagggccuuu gagcauccua                                                   20


<210>  10868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10868
ccacuuuaca gauugaggaa                                                   20


<210>  10869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10869
aucuguaaag uggggagaau                                                   20


<210>  10870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10870
gcuuccucaa ucuguaaagu                                                   20


<210>  10871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10871
gccuaaacca uuuuauuucg                                                   20


<210>  10872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10872
uugauuacac gaaauaaaau                                                   20


<210>  10873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10873
uucugucccu ccucccuuuc                                                   20


<210>  10874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10874
ucccuuucuu accagcucag                                                   20


<210>  10875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10875
cuuucuuacc agcucagguu                                                   20


<210>  10876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10876
gguuacaaag acaucuaggu                                                   20


<210>  10877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10877
caccuagaug ucuuuguaac                                                   20


<210>  10878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10878
cccaccuaga ugucuuugua                                                   20


<210>  10879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10879
aagggcuugg cugaguuggc                                                   20


<210>  10880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10880
gccaagcccu uagaggcagu                                                   20


<210>  10881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10881
cgcccgccaa cucagccaag                                                   20


<210>  10882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10882
ggguuuaucc cauggauacc                                                   20


<210>  10883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10883
uuuucuagua gcaaauaaaa                                                   20


<210>  10884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10884
cuuaugaggc cuagccaggg                                                   20


<210>  10885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10885
uaagggaggc aggauuuccu                                                   20


<210>  10886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10886
ucugguggga acuagaacau                                                   20


<210>  10887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10887
ggugggaacu agaacaugcc                                                   20


<210>  10888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10888
ugccaguuag uaacagggaa                                                   20


<210>  10889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10889
ugccacaagu ggcgaaguaa                                                   20


<210>  10890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10890
uuuaaugugc agucuuugcc                                                   20


<210>  10891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10891
ugcuugccaa cauucauaua                                                   20


<210>  10892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10892
uccuguguuu uuuaguuuau                                                   20


<210>  10893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10893
auuuucuuau cuucuuggcc                                                   20


<210>  10894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10894
aacaagagca ccuuuucccc                                                   20


<210>  10895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10895
uguuagaggc gcagccuuuc                                                   20


<210>  10896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10896
agaaaggcca ggggugggga                                                   20


<210>  10897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10897
aggaaggcuc aagaaaggcc                                                   20


<210>  10898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10898
gccaccgaca gcuuaauuca                                                   20


<210>  10899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10899
uuuuuuuuuu uuuuuuuaaa                                                   20


<210>  10900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10900
uggugcagug ggguggggcg                                                   20


<210>  10901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10901
cacaccuggu cgccugaaca                                                   20


<210>  10902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10902
caccuggucg ccugaacaca                                                   20


<210>  10903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10903
gguuacuggc guuaucacaa                                                   20


<210>  10904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10904
acugguucag aggagggaaa                                                   20


<210>  10905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10905
gaaccaguug aggccagucu                                                   20


<210>  10906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10906
ucugaaccag uugaggccag                                                   20


<210>  10907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10907
auuuuuuccc uccucugaac                                                   20


<210>  10908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10908
uuuuuuuuuu auuuuuuauu                                                   20


<210>  10909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10909
cuggucuuuu ggcuaaaggc                                                   20


<210>  10910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10910
caucuaaagc cuggcccucg                                                   20


<210>  10911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10911
ucuaaagccu ggcccucggc                                                   20


<210>  10912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10912
gccaaguuca ucuguuaaug                                                   20


<210>  10913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10913
cccaccuccc acuaccccuc                                                   20


<210>  10914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10914
cacuaccccu ccugagucuu                                                   20


<210>  10915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10915
ugagucuucu cuguucuccu                                                   20


<210>  10916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10916
ggagggguag ugggaggugg                                                   20


<210>  10917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10917
guucuccuac cucuuucgag                                                   20


<210>  10918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10918
uaccucuuuc gagcuccuaa                                                   20


<210>  10919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10919
uucgagcucc uaaaaacuag                                                   20


<210>  10920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10920
aaagagguag gagaacagag                                                   20


<210>  10921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10921
uaaaaacuag acaucgauua                                                   20


<210>  10922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10922
cuggccaugg uguagccaga                                                   20


<210>  10923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10923
cccuggccau gguguagcca                                                   20


<210>  10924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10924
caauguacaa uuuucccuuu                                                   20


<210>  10925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10925
uucccucuug ccacuaaccu                                                   20


<210>  10926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10926
ugccacuaac cucuuuucuu                                                   20


<210>  10927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10927
uuucuuuacc accuucuccg                                                   20


<210>  10928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10928
ggagcagaug gacuugacca                                                   20


<210>  10929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10929
ggagaaggug guaaagaaaa                                                   20


<210>  10930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10930
uggcaaccuc agaaauuaga                                                   20


<210>  10931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10931
gaaauuagag aaaaaaaaaa                                                   20


<210>  10932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10932
aauuucugag guugccagga                                                   20


<210>  10933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10933
uuuuuuuuuu uucucuaauu                                                   20


<210>  10934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10934
uggcuacccu acuccggucc                                                   20


<210>  10935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10935
gguccagguu uuucuccucc                                                   20


<210>  10936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10936
ucccucugug uugcccgacg                                                   20


<210>  10937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10937
cucuguguug cccgacgguc                                                   20


<210>  10938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10938
guguugcccg acgguccugc                                                   20


<210>  10939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10939
cacacuaaca cuaaaccaga                                                   20


<210>  10940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10940
cacuaacacu aaaccagaaa                                                   20


<210>  10941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10941
uuugcguucu gcaagaauau                                                   20


<210>  10942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10942
cuuaaaauau ucuugcagaa                                                   20


<210>  10943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10943
uuugaccauu uguaguuaua                                                   20


<210>  10944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10944
cauuugacca uuuguaguua                                                   20


<210>  10945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10945
aaaaaauauu aauaaaauac                                                   20


<210>  10946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10946
auacacuuug gcaggacuca                                                   20


<210>  10947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10947
gaccaaccac uaccauuaaa                                                   20


<210>  10948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10948
agagcguguu uuggcagugc                                                   20


<210>  10949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10949
ugaguuuaau gguagugguu                                                   20


<210>  10950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10950
uggugguguc ugcacagggc                                                   20


<210>  10951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10951
uccuaaccac ccucucugcc                                                   20


<210>  10952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10952
cugccggccg cagcuguucu                                                   20


<210>  10953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10953
gccggccgca gcuguucugu                                                   20


<210>  10954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10954
aaggacaaau gaaauccccc                                                   20


<210>  10955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10955
agacuagggc accaugagca                                                   20


<210>  10956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10956
uggugcccua gucuugaguu                                                   20


<210>  10957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10957
gaauccugca ccagcguugg                                                   20


<210>  10958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10958
acaacacuca gccucacgcc                                                   20


<210>  10959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10959
gccucacgcc ucaccccagc                                                   20


<210>  10960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10960
cgccucaccc cagcacuccc                                                   20


<210>  10961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10961
ccccagcacu cccugccucu                                                   20


<210>  10962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10962
cugccucugc cccucccccc                                                   20


<210>  10963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10963
gccccucccc ccaaauccaa                                                   20


<210>  10964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10964
ccccaaaucc aacacaccca                                                   20


<210>  10965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10965
aaauuugaag aacuucugug                                                   20


<210>  10966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10966
gcuaauuauu ucccucauuu                                                   20


<210>  10967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10967
uuuugcauuu caaggcacaa                                                   20


<210>  10968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10968
cugguggucu auuaauaguu                                                   20


<210>  10969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10969
aaacuucaaa cuauuaauag                                                   20


<210>  10970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10970
ggguauuaug auuugguuuc                                                   20


<210>  10971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10971
cugccugguu uacugauuua                                                   20


<210>  10972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10972
gccugguuua cugauuuaca                                                   20


<210>  10973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10973
cuguggcaaa cuguuuuuca                                                   20


<210>  10974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10974
acucccuuua aguacuucga                                                   20


<210>  10975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10975
cuuuaaguac uucgaaaaac                                                   20


<210>  10976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10976
uucaaaauca uguggcuuug                                                   20


<210>  10977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10977
uuagcuccuu caaaaucaug                                                   20


<210>  10978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10978
auuauauaac aaucuacccu                                                   20


<210>  10979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10979
auauaagcag aaguuuccag                                                   20


<210>  10980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10980
gcuauaauaa cacuuuacau                                                   20


<210>  10981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10981
uccaugcuca cguuuuuaac                                                   20


<210>  10982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10982
augcucacgu uuuuaacucu                                                   20


<210>  10983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10983
cguuuuuaac ucuaauacug                                                   20


<210>  10984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10984
aauacuguaa ucuuucuugc                                                   20


<210>  10985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10985
uggauagacu gaauaauaag                                                   20


<210>  10986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10986
cccaaacuuu acaagaaagg                                                   20


<210>  10987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10987
cccccaaacu uuacaagaaa                                                   20


<210>  10988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10988
cucccccaaa cuuuacaaga                                                   20


<210>  10989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10989
cucuccccca aacuuuacaa                                                   20


<210>  10990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10990
cucucucccc caaacuuuac                                                   20


<210>  10991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10991
ucucucucuc ccccaaacuu                                                   20


<210>  10992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10992
ccucucucuc ucccccaaac                                                   20


<210>  10993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10993
uucucuccuc ucucucuccc                                                   20


<210>  10994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10994
cuuucucucc ucucucucuc                                                   20


<210>  10995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10995
uucuaucuug caucaccccc                                                   20


<210>  10996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10996
ccuucuaucu ugcaucaccc                                                   20


<210>  10997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10997
cuccuucuau cuugcaucac                                                   20


<210>  10998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10998
acugcccacu cagccccaca                                                   20


<210>  10999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  10999
gccccacaua aaguaugaag                                                   20


<210>  11000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11000
ggccaacugc augcauaauu                                                   20


<210>  11001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11001
gacuucacag ccuuuggucu                                                   20


<210>  11002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11002
ccgacuucac agccuuuggu                                                   20


<210>  11003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11003
acacacacaa auaaaaagcc                                                   20


<210>  11004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11004
cagauggacc ccaucaguuc                                                   20


<210>  11005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11005
gagguuaaaa uuauaguuau                                                   20


<210>  11006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11006
gagggaccua gcacugcccu                                                   20


<210>  11007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11007
uaaaccaaag augaacauca                                                   20


<210>  11008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11008
caaaaaucgg aaaccguuag                                                   20


<210>  11009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11009
aaaaucggaa accguuaguu                                                   20


<210>  11010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11010
uguaccuuga gggagacacu                                                   20


<210>  11011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11011
agguacacga gugcccuggu                                                   20


<210>  11012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11012
cucaagguac acgagugccc                                                   20


<210>  11013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11013
cagugucucc cucaagguac                                                   20


<210>  11014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11014
cugggcuccc agugucuccc                                                   20


<210>  11015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11015
aggcucccug ggcucccagu                                                   20


<210>  11016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11016
ucaccaaagu auauccuggu                                                   20


<210>  11017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11017
ccucaucacc aaaguauauc                                                   20


<210>  11018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11018
gagcagcagc ugaaugagaa                                                   20


<210>  11019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11019
gagcuacaau guguccuccc                                                   20


<210>  11020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11020
uucagcugcu gcucugagcu                                                   20


<210>  11021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11021
uuuaucuuuu agaucaagua                                                   20


<210>  11022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11022
uccaaaggag gaaccugaug                                                   20


<210>  11023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11023
aaaggaggaa ccugaugucu                                                   20


<210>  11024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11024
uuuggaggag ggaaggcuac                                                   20


<210>  11025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11025
auguaucugg aagugccuca                                                   20


<210>  11026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11026
aucauauacu uaaauuuuac                                                   20


<210>  11027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11027
ccaaaugaga acgauuucca                                                   20


<210>  11028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11028
uuuggggaga agacuguaaa                                                   20


<210>  11029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11029
agguuagacu ucuaauuccu                                                   20


<210>  11030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11030
auucacuaaa ggaaacuugg                                                   20


<210>  11031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11031
uuucuacugg ggcaucugag                                                   20


<210>  11032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11032
gaugccccag uagaaaggag                                                   20


<210>  11033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11033
ucagaugccc caguagaaag                                                   20


<210>  11034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11034
uccucagaug ccccaguaga                                                   20


<210>  11035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11035
ccuccucaga ugccccagua                                                   20


<210>  11036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11036
guggcucucc uccucagaug                                                   20


<210>  11037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11037
uucauuaaug uaauuugcau                                                   20


<210>  11038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11038
uggugaacuu uuaaucuuga                                                   20


<210>  11039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11039
agauuaaaag uucaccaaga                                                   20


<210>  11040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11040
uucagcaggc ugacaggcca                                                   20


<210>  11041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11041
uuugaauuuu aagcacuucu                                                   20


<210>  11042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11042
uuuuuuuaau gcaaaauugu                                                   20


<210>  11043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11043
gucuggaaga uauuacaauu                                                   20


<210>  11044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11044
auguuuaguu uaagcucagu                                                   20


<210>  11045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11045
guuuguaucu uagccccuuu                                                   20


<210>  11046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11046
uaagggcuua guuuuaugaa                                                   20


<210>  11047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11047
aaacauggua auuuaucaaa                                                   20


<210>  11048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11048
gggcuguuuu ugauaaauua                                                   20


<210>  11049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11049
uaggcaauac ugcauagucc                                                   20


<210>  11050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11050
aacagaacag auuaacacga                                                   20


<210>  11051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11051
uguuaaucug uucuguugga                                                   20


<210>  11052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11052
acccuuccaa aaagccuuuu                                                   20


<210>  11053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11053
aguugucucu ccuguguaaa                                                   20


<210>  11054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11054
ccuguguaaa cauccacugu                                                   20


<210>  11055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11055
uguguaaaca uccacugugg                                                   20


<210>  11056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11056
aagccaauga aaaagcuguu                                                   20


<210>  11057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11057
uuucuugcug guuucccuuu                                                   20


<210>  11058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11058
ugugcuucuc cuuucuugcu                                                   20


<210>  11059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11059
cuccugugcu ucuccuuucu                                                   20


<210>  11060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11060
cccuccugug cuucuccuuu                                                   20


<210>  11061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11061
ucucccuccu gugcuucucc                                                   20


<210>  11062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11062
gaaguaaacc agaccuugcu                                                   20


<210>  11063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11063
ucagaaguaa accagaccuu                                                   20


<210>  11064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11064
agcaacagga uuugcacucc                                                   20


<210>  11065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11065
auucggcacc agccgcauuu                                                   20


<210>  11066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11066
aauaacuggg gugggauggu                                                   20


<210>  11067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11067
cuaauaacug gggugggaug                                                   20


<210>  11068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11068
agacuaguaa uuggaaagcc                                                   20


<210>  11069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11069
caccuugcua accuccugac                                                   20


<210>  11070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11070
ugacauuuaa aaaauucuag                                                   20


<210>  11071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11071
uccucuuccu cccaacccca                                                   20


<210>  11072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11072
ucuuccuccc aaccccaacc                                                   20


<210>  11073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11073
uccucccaac cccaaccucu                                                   20


<210>  11074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11074
caaccccaac cucuccaacc                                                   20


<210>  11075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11075
ccaacccagg ugaaagcaag                                                   20


<210>  11076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11076
aacccaggug aaagcaagaa                                                   20


<210>  11077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11077
gcuggugugc aagucagacu                                                   20


<210>  11078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11078
gucugacuug cacaccagcu                                                   20


<210>  11079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11079
acugcuagac ccaaaagcuc                                                   20


<210>  11080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11080
cugcuguggg gauuucauuu                                                   20


<210>  11081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11081
gcugugggga uuucauuuga                                                   20


<210>  11082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11082
cuccgcaccc uucucccccu                                                   20


<210>  11083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11083
ccgcacccuu cucccccucu                                                   20


<210>  11084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11084
gcacccuucu cccccucucu                                                   20


<210>  11085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11085
cccucucucc cccagccuca                                                   20


<210>  11086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11086
cucccccagc cucagacuuu                                                   20


<210>  11087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11087
cccccagccu cagacuuucu                                                   20


<210>  11088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11088
cccagccuca gacuuucucc                                                   20


<210>  11089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11089
gacuuucucc uagaguugau                                                   20


<210>  11090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11090
uagaguugau cuuaccggaa                                                   20


<210>  11091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11091
aggagaaagu cugaggcugg                                                   20


<210>  11092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11092
uuccgauuuc cuugauaaca                                                   20


<210>  11093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11093
cuucucuuuc cgauuuccuu                                                   20


<210>  11094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11094
gguacuaccc ccugauuucu                                                   20


<210>  11095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11095
cuuauccuug ggcccugcuc                                                   20


<210>  11096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11096
uauccuuggg cccugcucag                                                   20


<210>  11097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11097
gaaaugugcc acauuuuaac                                                   20


<210>  11098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11098
gcauccuauc cuuucuaaua                                                   20


<210>  11099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11099
uacagauggu uguggaugug                                                   20


<210>  11100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11100
acaugaguag aguucaauga                                                   20


<210>  11101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11101
uguagaguaa cauuaguguc                                                   20


<210>  11102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11102
acucauguag aguaacauua                                                   20


<210>  11103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11103
uugaacucua cucauguaga                                                   20


<210>  11104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11104
guaguguagc auugguuucu                                                   20


<210>  11105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11105
aauagggaaa aucacuugaa                                                   20


<210>  11106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11106
aggcuuccua uaugcauucc                                                   20


<210>  11107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11107
uuaaauacaa uaccuauaua                                                   20


<210>  11108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11108
uaucugcuug gggcagccug                                                   20


<210>  11109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11109
ccuccuaucu gcuuggggca                                                   20


<210>  11110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11110
gggucccccu ccccuccuau                                                   20


<210>  11111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11111
auuguacaaa caaguacgug                                                   20


<210>  11112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11112
aagaucagaa gaaauacaua                                                   20


<210>  11113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11113
aauguuuuag uuaaaaggac                                                   20


<210>  11114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11114
uggaucuuug aaaacaacug                                                   20


<210>  11115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11115
uuaacauaac aaaaacauaa                                                   20


<210>  11116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11116
uguuauguuu uuguuauguu                                                   20


<210>  11117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11117
aucacacccu aauauuuuaa                                                   20


<210>  11118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11118
ccaucacacc cuaauauuuu                                                   20


<210>  11119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11119
cgagauuuaa gauuuaacau                                                   20


<210>  11120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11120
ugaguuucuc uccaucacac                                                   20


<210>  11121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11121
ccugccccga uccuuucagu                                                   20


<210>  11122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11122
ccauuuuaac uccccugccc                                                   20


<210>  11123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11123
gugaaccauu uacuccccau                                                   20


<210>  11124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11124
agguauacca ugauuuuaug                                                   20


<210>  11125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11125
uucaccaacu caagguauac                                                   20


<210>  11126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11126
uaguuuuuug agguuuguuu                                                   20


<210>  11127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11127
aaaaacuaag agaaccaaac                                                   20


<210>  11128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11128
aacaaaaaca aaccucaaaa                                                   20


<210>  11129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11129
ucaaacaaaa acaaaccuca                                                   20


<210>  11130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11130
auauuuaaaa uguacaggaa                                                   20


<210>  11131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11131
aacauaagaa uccaagcuac                                                   20


<210>  11132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11132
ccuuucuauu ugcuuuuuga                                                   20


<210>  11133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11133
cauuaaaaua aagaauggaa                                                   20


<210>  11134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11134
aucuaaaacu aaaaucaaau                                                   20


<210>  11135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11135
cuguuguuag cauugccaau                                                   20


<210>  11136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11136
uugugaguga ccaaaggucc                                                   20


<210>  11137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11137
caaugaguuu uuguuuguau                                                   20


<210>  11138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11138
agguucccac ugggaauucu                                                   20


<210>  11139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11139
ggcagagacu gauucaguuc                                                   20


<210>  11140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11140
gccagagaau ucccaguggg                                                   20


<210>  11141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11141
ccucuuuuac aggaaguuua                                                   20


<210>  11142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11142
uuuacaggaa guuuaaaccu                                                   20


<210>  11143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11143
ccuuuaggua uauauaauuu                                                   20


<210>  11144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11144
gagaacuugg uauuuuaucu                                                   20


<210>  11145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11145
gagugcuaaa caacaaauua                                                   20


<210>  11146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11146
uuagauagau aaaauaccaa                                                   20


<210>  11147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11147
aucuuuugcc cuuuuugauc                                                   20


<210>  11148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11148
cuccaucuuu ugcccuuuuu                                                   20


<210>  11149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11149
gcucgcucca ucuuuugccc                                                   20


<210>  11150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11150
ggugcauacg ucaaucgugc                                                   20


<210>  11151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11151
aaggcaacgc gcagugcacg                                                   20


<210>  11152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11152
ucuaaggcaa cgcgcagugc                                                   20


<210>  11153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11153
caucagucuc cagggugaac                                                   20


<210>  11154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11154
agggugaacc aagagaugac                                                   20


<210>  11155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11155
ugguucaccc uggagacuga                                                   20


<210>  11156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11156
agcaaugugg acucaaaaau                                                   20


<210>  11157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11157
aaaauauaau ggugaaauau                                                   20


<210>  11158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11158
cucucucucu cucucugugu                                                   20


<210>  11159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11159
cucucucucu cucugugugu                                                   20


<210>  11160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11160
cucucucucu cugugugugu                                                   20


<210>  11161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11161
cucucucucu gugugugugu                                                   20


<210>  11162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11162
cucucucugu gugugugugu                                                   20


<210>  11163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11163
cucucugugu gugugugugu                                                   20


<210>  11164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11164
cucugugugu gugugugugu                                                   20


<210>  11165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11165
cugugugugu gugugugugu                                                   20


<210>  11166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11166
gugugugugu gugugugugu                                                   20


<210>  11167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11167
uuccccauua cacacacaca                                                   20


<210>  11168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11168
cuuuguucaa aucacauacu                                                   20


<210>  11169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11169
auaccagcac augcaaaaaa                                                   20


<210>  11170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11170
caauucacca ccagaauuuu                                                   20


<210>  11171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11171
gccaccuccc aauucaccac                                                   20


<210>  11172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11172
ccaacucugc caccucccaa                                                   20


<210>  11173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11173
aagagaagaa aaggaugaug                                                   20


<210>  11174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11174
uggaguuguc uccccaacuc                                                   20


<210>  11175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11175
uuugaucuau agcgaaauga                                                   20


<210>  11176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11176
auaugccaca guuuccauuc                                                   20


<210>  11177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11177
gcaucugaca gggcauuuac                                                   20


<210>  11178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11178
gaugggcgca uguaaaugcc                                                   20


<210>  11179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11179
ggugccgcuc agaugggcgc                                                   20


<210>  11180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11180
caggugccgc ucagaugggc                                                   20


<210>  11181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11181
uccaaggugc aguaacugug                                                   20


<210>  11182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11182
aaggugcagu aacugugcgc                                                   20


<210>  11183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11183
ccuauucccu gcugggauca                                                   20


<210>  11184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11184
ccacccccca ugccucaaau                                                   20


<210>  11185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11185
aauccuuccc uugccaaccu                                                   20


<210>  11186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11186
augccauugc agaaugacga                                                   20


<210>  11187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11187
uucgucauuc ugcaauggca                                                   20


<210>  11188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11188
gaaauagacc ccaaguuacu                                                   20


<210>  11189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11189
cuaugcauuu uuaaaacauu                                                   20


<210>  11190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11190
cugcuuuuua cuggccagcu                                                   20


<210>  11191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11191
auuugaagcc aguaaacauc                                                   20


<210>  11192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11192
aggagcacau guagagagcu                                                   20


<210>  11193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11193
uagagaccaa aggcagauuu                                                   20


<210>  11194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11194
acaugugcuc cuagagacca                                                   20


<210>  11195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11195
cuacaugugc uccuagagac                                                   20


<210>  11196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11196
aguagcaaua auaugguucg                                                   20


<210>  11197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11197
aauuaauuag gucauguugu                                                   20


<210>  11198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11198
auacccuggu cguaaagggg                                                   20


<210>  11199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11199
ccuuuacgac caggguauag                                                   20


<210>  11200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11200
uaccuaggua aaugggcauc                                                   20


<210>  11201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11201
uugguucuuu ucuccuaccu                                                   20


<210>  11202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11202
cuccuugguu cuuuucuccu                                                   20


<210>  11203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11203
cucccuccuu gguucuuuuc                                                   20


<210>  11204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11204
aaguuagaau cuuuuuuuuu                                                   20


<210>  11205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11205
ugcuaaaaaa guggcaaggu                                                   20


<210>  11206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11206
cuagcugugc uuucuacuuc                                                   20


<210>  11207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11207
uuuauuaaac auuuucauug                                                   20


<210>  11208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11208
augaaaaugu uuaauaaagg                                                   20


<210>  11209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11209
cacauuagcc aaacuacaug                                                   20


<210>  11210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11210
aaaagaugcc auuaauaagc                                                   20


<210>  11211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11211
ccuccucccu gagcugaagg                                                   20


<210>  11212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11212
ucccugagcu gaagguugcc                                                   20


<210>  11213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11213
cugagcugaa gguugccugu                                                   20


<210>  11214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11214
gggaggaggc gaguuggaug                                                   20


<210>  11215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11215
acaauuauau gccacauuca                                                   20


<210>  11216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11216
uagugaaugu ggcauauaau                                                   20


<210>  11217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11217
guguuuauuc ugugaaagcu                                                   20


<210>  11218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11218
cguucucugu guuuauucug                                                   20


<210>  11219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11219
gcuccuguuc uugaagugaa                                                   20


<210>  11220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11220
uguucuugaa gugaauacau                                                   20


<210>  11221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11221
ugcuguuaca gacaguuaau                                                   20


<210>  11222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11222
acaucacaca caggaugauc                                                   20


<210>  11223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11223
aaacauuauu uauaaaagau                                                   20


<210>  11224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11224
aucaugcaau cacugugaca                                                   20


<210>  11225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11225
uucuaagaca aauuguaaau                                                   20


<210>  11226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11226
gacauuguac uuugacaaaa                                                   20


<210>  11227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11227
gucuuauuua caaauacagc                                                   20


<210>  11228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11228
caguuucaug aacauuaguc                                                   20


<210>  11229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11229
caaacauagg cucccuauga                                                   20


<210>  11230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11230
cuaugaaaau ccuagguacu                                                   20


<210>  11231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11231
acucucugga uuuugaaggu                                                   20


<210>  11232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11232
cuggauuuug aagguaagua                                                   20


<210>  11233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11233
ggauuuugaa gguaaguaaa                                                   20


<210>  11234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11234
uuauuuaugu gauucugaau                                                   20


<210>  11235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11235
uuuacaauua caccauaagg                                                   20


<210>  11236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11236
aguucagucu gagcuaggag                                                   20


<210>  11237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11237
gacugaacug gaggauguau                                                   20


<210>  11238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11238
uagcucagac ugaacuggag                                                   20


<210>  11239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11239
ccuagcucag acugaacugg                                                   20


<210>  11240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11240
uaaaaguaaa ucaaauacaa                                                   20


<210>  11241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11241
cuucuuuaga guaucugucu                                                   20


<210>  11242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11242
aaagaaggga gauauaguaa                                                   20


<210>  11243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11243
uuaaaaucau gaacauagac                                                   20


<210>  11244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11244
uguugauaua uaacauuuuu                                                   20


<210>  11245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11245
agucucucaa aaagcuaacu                                                   20


<210>  11246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11246
caaaaagcua acuuuaugac                                                   20


<210>  11247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11247
aaaagcuaac uuuaugacag                                                   20


<210>  11248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11248
aaucugacau gaugggauaa                                                   20


<210>  11249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11249
uauuuuauga uggggggaaa                                                   20


<210>  11250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11250
gacugcaagu caaaggcugc                                                   20


<210>  11251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11251
gauaucagca gccuuugacu                                                   20


<210>  11252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11252
auggaucaca aucacacaau                                                   20


<210>  11253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11253
uauguguacg uggaugaagu                                                   20


<210>  11254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11254
cccacuucau ccacguacac                                                   20


<210>  11255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11255
aaaaaauacu caguuugggc                                                   20


<210>  11256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11256
guuugggcca ggugcggucg                                                   20


<210>  11257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11257
agccuguaau cccagcacuu                                                   20


<210>  11258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11258
caaagugcug ggauuacagg                                                   20


<210>  11259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11259
ggugauccac cuggcuuggc                                                   20


<210>  11260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11260
ugaccucagg ugauccaccu                                                   20


<210>  11261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11261
acugaaaaua caaaaaacua                                                   20


<210>  11262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11262
caaguagcug ggauuacagg                                                   20


<210>  11263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11263
gccucccaag uagcugggau                                                   20


<210>  11264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11264
ugccucagcc ucccaaguag                                                   20


<210>  11265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11265
uagguucaag cgauucuccu                                                   20


<210>  11266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11266
gccuccuagg uucaagcgau                                                   20


<210>  11267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11267
cugcaaccuc ugccuccuag                                                   20


<210>  11268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11268
agccugggca acaagagcaa                                                   20


<210>  11269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11269
uguugcccag gcuggagugc                                                   20


<210>  11270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11270
gucuaaaaaa aaaaaaaaaa                                                   20


<210>  11271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11271
gcuuggagag gccugaguac                                                   20


<210>  11272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11272
aagcugaguu uuuuuuuuuu                                                   20


<210>  11273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11273
ccaagcugag uuuuuuuuuu                                                   20


<210>  11274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11274
ggccucucca agcugaguuu                                                   20


<210>  11275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11275
agauuuaaag aacucugccu                                                   20


<210>  11276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11276
gccuuauucu ccuaucugaa                                                   20


<210>  11277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11277
uaucugaaag ucccgaauuc                                                   20


<210>  11278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11278
cagugaacuc aaauccaacu                                                   20


<210>  11279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11279
aauccaacuu acaucacuuu                                                   20


<210>  11280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11280
agaagaaugu guuuggcaac                                                   20


<210>  11281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11281
uuccuuaaua caaggcauug                                                   20


<210>  11282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11282
uuucuuuuug ugacacaauu                                                   20


<210>  11283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11283
ucauaaaaag aaaagcagac                                                   20


<210>  11284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11284
aaagcacguc ugcacaauuc                                                   20


<210>  11285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11285
ggugccccug aagcgaaguu                                                   20


<210>  11286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11286
ggcccucagg ugccccugaa                                                   20


<210>  11287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11287
uaauucauua cugugaauua                                                   20


<210>  11288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11288
uaauucacag uaaugaauua                                                   20


<210>  11289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11289
cuuugagaug ugaccacacu                                                   20


<210>  11290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11290
aagugagaug ucaguaacua                                                   20


<210>  11291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11291
ccugggucac agcacuuguu                                                   20


<210>  11292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11292
aagaugucua agauauucaa                                                   20


<210>  11293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11293
cuaagauguc uaagauauuc                                                   20


<210>  11294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11294
guuaaaugau ugauuauuag                                                   20


<210>  11295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11295
aggcucugcu auuauacuug                                                   20


<210>  11296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11296
gcuauuauac uuguucuuua                                                   20


<210>  11297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11297
cugguugucu aaagguucug                                                   20


<210>  11298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11298
uauuucccua cauagauuca                                                   20


<210>  11299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11299
ucuaaauaca gaggcacaga                                                   20


<210>  11300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11300
aaauacagag gcacagaauu                                                   20


<210>  11301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11301
guauuuagag gaggaaucua                                                   20


<210>  11302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11302
aaaauucugu gccucuguau                                                   20


<210>  11303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11303
guaagaagug ugguuuuaau                                                   20


<210>  11304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11304
uuuaaaagac aaaacacagu                                                   20


<210>  11305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11305
auauguaaau acgauguuac                                                   20


<210>  11306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11306
auauuuggug auuuagcaag                                                   20


<210>  11307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11307
gaagacgaca aauccccuuc                                                   20


<210>  11308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11308
ugcuucauua aucaugccuu                                                   20


<210>  11309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11309
ccuacccccc agcaggaugu                                                   20


<210>  11310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11310
acaaaugcag cuucccuagc                                                   20


<210>  11311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11311
gauacuuucc cuuuagugaa                                                   20


<210>  11312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11312
agaauuugau cauuaaaacc                                                   20


<210>  11313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11313
cccucuagaa uuugaucauu                                                   20


<210>  11314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11314
cccccucuag aauuugauca                                                   20


<210>  11315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11315
ucucccccuc uagaauuuga                                                   20


<210>  11316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11316
agaccacuga ccuauuaugg                                                   20


<210>  11317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11317
gaccuaguuu gaccacaaag                                                   20


<210>  11318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11318
ccgaccuagu uugaccacaa                                                   20


<210>  11319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11319
ugccuuucgg gagcugggug                                                   20


<210>  11320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11320
cgaaaggcaa gagguuuguu                                                   20


<210>  11321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11321
agcaaaaaau guuuugaggg                                                   20


<210>  11322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11322
aaacauuuuu ugcuugagca                                                   20


<210>  11323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11323
aagugauaaa caguaacacu                                                   20


<210>  11324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11324
agggaaaagg aauuaaaggc                                                   20


<210>  11325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11325
gcagcucaag ggaaaaggaa                                                   20


<210>  11326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11326
cugcuaaaau uaaccaaagg                                                   20


<210>  11327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11327
uuugguuaau uuuagcaggg                                                   20


<210>  11328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11328
cuccuuuggu uaauuuuagc                                                   20


<210>  11329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11329
acuguuucug cuauaacaca                                                   20


<210>  11330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11330
gaugugguuu ugacagaugu                                                   20


<210>  11331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11331
ugucucugau gugguuuuga                                                   20


<210>  11332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11332
cuugucucug augugguuuu                                                   20


<210>  11333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11333
cucuugucuc ugaugugguu                                                   20


<210>  11334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11334
gugcucucuc uugucucuga                                                   20


<210>  11335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11335
gcuaaaugau aaaugcuucu                                                   20


<210>  11336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11336
ucagcuaaau gauaaaugcu                                                   20


<210>  11337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11337
cugcagccug ccuccucagc                                                   20


<210>  11338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11338
aaaaguuuaa gggcauguug                                                   20


<210>  11339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11339
cuacucuggc cuggccaguc                                                   20


<210>  11340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11340
acucuggccu ggccagucga                                                   20


<210>  11341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11341
ggccuggcca gucgaaaaug                                                   20


<210>  11342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11342
guuaacucuu uccaccaccu                                                   20


<210>  11343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11343
uuccaccacc uccaacuacc                                                   20


<210>  11344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11344
aacuacccug ccagcccacu                                                   20


<210>  11345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11345
acuucaggga agccuugaga                                                   20


<210>  11346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11346
aggcuucccu gaaguagagu                                                   20


<210>  11347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11347
uucucaaggc uucccugaag                                                   20


<210>  11348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11348
uuagggguuc agcucguucu                                                   20


<210>  11349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11349
gaacaucugg ccaggccucc                                                   20


<210>  11350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11350
gacacgucac caaggcugga                                                   20


<210>  11351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11351
auacuucaaa augagaaggu                                                   20


<210>  11352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11352
uuuugaagua uugagcuuua                                                   20


<210>  11353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11353
ggaucugucg auuuuggauu                                                   20


<210>  11354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11354
cuggaucugu cgauuuugga                                                   20


<210>  11355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11355
cugaaucaga uguaggcagg                                                   20


<210>  11356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11356
augugacugu ccaugacagc                                                   20


<210>  11357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11357
auuacucuau gugacugucc                                                   20


<210>  11358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11358
uuacugcuug gcuacagcac                                                   20


<210>  11359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11359
gaaaaugaaa agaaaacaug                                                   20


<210>  11360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11360
uugcuucuca uuuaccugcu                                                   20


<210>  11361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11361
uuuaccugcu auguguuccu                                                   20


<210>  11362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11362
agaugacguu gauaaacaau                                                   20


<210>  11363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11363
ggcgugaccu ggaugccaac                                                   20


<210>  11364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11364
acgggauugg augcuuuuuu                                                   20


<210>  11365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11365
auuggugaag gggaaggugg                                                   20


<210>  11366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11366
gcuuagaaaa agcuguggau                                                   20


<210>  11367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11367
auaaaaauaa gaaugucccc                                                   20


<210>  11368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11368
ccugugggca gugccagaug                                                   20


<210>  11369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11369
ucaccugugg gcagugccag                                                   20


<210>  11370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11370
agaaggggau caugaccucc                                                   20


<210>  11371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11371
caacgggccg uggucugguu                                                   20


<210>  11372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11372
ugaagccauu cuuacagaug                                                   20


<210>  11373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11373
gcugugguug gagaaacaaa                                                   20


<210>  11374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11374
aaccacagcc gagccucuug                                                   20


<210>  11375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11375
aauaauugug cuuuuguuuc                                                   20


<210>  11376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11376
ggcacucuaa uaauugugcu                                                   20


<210>  11377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11377
cuggcacucu aauaauugug                                                   20


<210>  11378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11378
ccuuucuguc cucucuggca                                                   20


<210>  11379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11379
accccaugcc aucccaccac                                                   20


<210>  11380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11380
auauaauacc cagaaaaugu                                                   20


<210>  11381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11381
cauuuucugg guauuauaua                                                   20


<210>  11382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11382
gguugauaac cuucacaucc                                                   20


<210>  11383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11383
cugguugaua accuucacau                                                   20


<210>  11384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11384
uugacaaauu ugcucucugg                                                   20


<210>  11385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11385
agagaacaca cacacacaca                                                   20


<210>  11386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11386
ggaguuaugc aaggaagacu                                                   20


<210>  11387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11387
uuucauucuu uggcacaaug                                                   20


<210>  11388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11388
ccuuucauuc uuuggcacaa                                                   20


<210>  11389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11389
uaaguaaaca gacauggcuu                                                   20


<210>  11390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11390
cacucucagc agugccacaa                                                   20


<210>  11391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11391
cucucagcag ugccacaaaa                                                   20


<210>  11392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11392
cagcagugcc acaaaaucaa                                                   20


<210>  11393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11393
gcagugccac aaaaucaaag                                                   20


<210>  11394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11394
gacacauuag cuaaauggga                                                   20


<210>  11395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11395
aaaguauccc auuuagcuaa                                                   20


<210>  11396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11396
gaauaaaaaa aaaaugacua                                                   20


<210>  11397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11397
gaaauguggu guuugcuuga                                                   20


<210>  11398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11398
gccuugcucu gaaauguggu                                                   20


<210>  11399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11399
uucagaaaau uaguccacuu                                                   20


<210>  11400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11400
aaaaugcuuc auuaugagac                                                   20


<210>  11401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11401
uaaugaagca uuuuggagcu                                                   20


<210>  11402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11402
agcaucuacu uuaccagcuu                                                   20


<210>  11403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11403
uuuccccuuu ggaagcuuaa                                                   20


<210>  11404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11404
cuuuuccccu uuggaagcuu                                                   20


<210>  11405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11405
gcuugugaaa ucuuaugcuu                                                   20


<210>  11406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11406
aucaaaaaaa aaaaaaaaau                                                   20


<210>  11407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11407
guggcuuuaa guucauuaaa                                                   20


<210>  11408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11408
aauuaaaauc uauuuuuuga                                                   20


<210>  11409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11409
gguuaaauuu auuucaaccc                                                   20


<210>  11410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11410
auauucagcc uggguagggu                                                   20


<210>  11411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11411
agaucuuccc ccucaauauu                                                   20


<210>  11412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11412
cagaugugcu aggugaaaua                                                   20


<210>  11413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11413
auauuauuuc accuagcaca                                                   20


<210>  11414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11414
caauauuauu ucaccuagca                                                   20


<210>  11415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11415
cucaauauua uuucaccuag                                                   20


<210>  11416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11416
aguaggacau cucauaauuu                                                   20


<210>  11417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11417
uaauuucuag ccucugguac                                                   20


<210>  11418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11418
gguacuccuc cuaauuuaac                                                   20


<210>  11419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11419
uccuaauuua acauaagguc                                                   20


<210>  11420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11420
uaauuuaaca uaaggucacc                                                   20


<210>  11421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11421
gcauugugcc uuaaugucau                                                   20


<210>  11422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11422
uacauuugcu uccauuuuga                                                   20


<210>  11423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11423
cuuggucaaa auggaagcaa                                                   20


<210>  11424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11424
uucucaaaau auuccuguug                                                   20


<210>  11425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11425
aaauauuccu guugucugaa                                                   20


<210>  11426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11426
gaacuuguag cuaaugcuaa                                                   20


<210>  11427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11427
uagguaucaa auaguuaaag                                                   20


<210>  11428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11428
gaauuaccac uucauuuccc                                                   20


<210>  11429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11429
acauuucacc uaauuaauuu                                                   20


<210>  11430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11430
uauaaaauua auuaggugaa                                                   20


<210>  11431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11431
acauuuucua ugcucuuaac                                                   20


<210>  11432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11432
uaacguaaau uauugcuaau                                                   20


<210>  11433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11433
uugcaaaaca uuuggcuagu                                                   20


<210>  11434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11434
gaacaccacu agccaaaugu                                                   20


<210>  11435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11435
ugguguaguc uacugauuug                                                   20


<210>  11436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11436
guggcaauca acauuuccuu                                                   20


<210>  11437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11437
gcauuuuaau gcaaauuccc                                                   20


<210>  11438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11438
gccauuuacc cccucccuca                                                   20


<210>  11439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11439
cucaauucaa cuccauccuc                                                   20


<210>  11440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11440
auucaacucc auccuccuuc                                                   20


<210>  11441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11441
auccuccuuc gccccaacaa                                                   20


<210>  11442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11442
uucgccccaa caauaccaac                                                   20


<210>  11443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11443
ggccuaaacu ccggcuacaa                                                   20


<210>  11444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11444
ggcuacaaag cagggagucc                                                   20


<210>  11445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11445
cugcuuugua gccggaguuu                                                   20


<210>  11446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11446
auugaagugg aagggagugg                                                   20


<210>  11447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11447
cuuccacuuc aaucgaggac                                                   20


<210>  11448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11448
cuacgagggg aggaagaaau                                                   20


<210>  11449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11449
acgaggggag gaagaaauag                                                   20


<210>  11450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11450
uagagagaau ucgcggcuaa                                                   20


<210>  11451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11451
ccucguagag agaauucgcg                                                   20


<210>  11452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11452
augucucagu gacagacuga                                                   20


<210>  11453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11453
gugacagacu gagaucucuu                                                   20


<210>  11454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11454
gucugucacu gagacauuga                                                   20


<210>  11455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11455
uuccucucug uguaguugca                                                   20


<210>  11456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11456
cuguguaguu gcaaaagaau                                                   20


<210>  11457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11457
guguaguugc aaaagaauaa                                                   20


<210>  11458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11458
uuaccaacau uuccuauaag                                                   20


<210>  11459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11459
cuccuuacca acauuuccua                                                   20


<210>  11460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11460
uuuugcucgc uccuuaccaa                                                   20


<210>  11461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11461
cguuuugcuc gcuccuuacc                                                   20


<210>  11462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11462
ccggcagcuc ucguuuugcu                                                   20


<210>  11463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11463
gcuccccggc agcucucguu                                                   20


<210>  11464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11464
cccuccgcuc cccggcagcu                                                   20


<210>  11465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11465
cuuucccccu cccccuccgc                                                   20


<210>  11466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11466
uugauugucu uaacagggua                                                   20


<210>  11467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11467
guuugcuucu uuacccuguu                                                   20


<210>  11468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11468
gaauuucagc cuccguuugc                                                   20


<210>  11469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11469
cugaauuuca gccuccguuu                                                   20


<210>  11470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11470
gaggcacaaa gcgagcagcg                                                   20


<210>  11471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11471
gaguccccgc gcccaacuuc                                                   20


<210>  11472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11472
cuuugugccu cagagucccc                                                   20


<210>  11473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11473
cgccgcgcuu gcugcgaaca                                                   20


<210>  11474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11474
gggcccccgg gccccaaggc                                                   20


<210>  11475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11475
gucuccgggc ccccgggccc                                                   20


<210>  11476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11476
augcccgucc agcucggcca                                                   20


<210>  11477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11477
gccagcucgg ccgcggggug                                                   20


<210>  11478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11478
gccgcggggu gacgguuccc                                                   20


<210>  11479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11479
cuuccuuuuu caccaacugg                                                   20


<210>  11480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11480
guaucuccgc acacaccuca                                                   20


<210>  11481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11481
gcacacaccu caagcgcggg                                                   20


<210>  11482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11482
agcgcggguc cugagauuca                                                   20


<210>  11483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11483
ggacccgcgc uugaggugug                                                   20


<210>  11484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11484
gcaaaugcau uucccccgca                                                   20


<210>  11485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11485
gaaucacaac aauaguaaua                                                   20


<210>  11486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11486
gaggcgagag gggggguguc                                                   20


<210>  11487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11487
gagcucggaa ucacaacaau                                                   20


<210>  11488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11488
ccucggagcu cggaaucaca                                                   20


<210>  11489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11489
cgccucggag cucggaauca                                                   20


<210>  11490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11490
gcagcccgac acccccccuc                                                   20


<210>  11491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11491
gcuggcuugc ugggcggcuc                                                   20


<210>  11492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11492
guggccucgg cuggcuugcu                                                   20


<210>  11493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11493
cccccaugca aagcacagac                                                   20


<210>  11494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11494
cuucuuccac ccccucaccc                                                   20


<210>  11495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11495
agccucacuu cuuccacccc                                                   20


<210>  11496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11496
ucggccaugc cccgaagccc                                                   20


<210>  11497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11497
agggcuucgg ggcauggccg                                                   20


<210>  11498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11498
cgguuccucc cuaccaaaaa                                                   20


<210>  11499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11499
cuaccaaaaa ugccggcccc                                                   20


<210>  11500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11500
gagcccggcg cgcgcugguc                                                   20


<210>  11501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11501
gagcacggug caguuuucgc                                                   20


<210>  11502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11502
gcucgcgcac gggggugucg                                                   20


<210>  11503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11503
cgcacggggg ugucggccgc                                                   20


<210>  11504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11504
gcggccccgg ccagaagcau                                                   20


<210>  11505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11505
cccaucaccc cguaugucuu                                                   20


<210>  11506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11506
cccccaucac cccguauguc                                                   20


<210>  11507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11507
caaagcucgu uccuccccgg                                                   20


<210>  11508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11508
uuccuccccg gacgagaauc                                                   20


<210>  11509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11509
ccggacgaga aucgccgggc                                                   20


<210>  11510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11510
uccggggagg aacgagcuuu                                                   20


<210>  11511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11511
ugcccggcga uucucguccg                                                   20


<210>  11512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11512
cccaccuccu gcccggcgau                                                   20


<210>  11513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11513
gguacagguu caaguucgcu                                                   20


<210>  11514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11514
gcgaacuuga accuguacca                                                   20


<210>  11515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11515
uagcgaccga auggcucauu                                                   20


<210>  11516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11516
uucagcccac auagcagagg                                                   20


<210>  11517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11517
gcuauguggg cugaaugagc                                                   20


<210>  11518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11518
guaccacccc cccgcccccc                                                   20


<210>  11519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11519
ugcccccucu gagcacccag                                                   20


<210>  11520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11520
gagcacccag aaaaugagga                                                   20


<210>  11521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11521
gagggggcag gagccauccc                                                   20


<210>  11522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11522
uuuucugggu gcucagaggg                                                   20


<210>  11523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11523
cccccuccca aacuggcccu                                                   20


<210>  11524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11524
caaacuggcc cuuuaacccc                                                   20


<210>  11525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11525
ugucccgggg uuaaagggcc                                                   20


<210>  11526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11526
uccugucccg ggguuaaagg                                                   20


<210>  11527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11527
cagccuagag ugucccaaga                                                   20


<210>  11528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11528
aggcugggag gguuaguacc                                                   20


<210>  11529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11529
uggguccauc uugggacacu                                                   20


<210>  11530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11530
cuccuggguc caucuuggga                                                   20


<210>  11531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11531
cccuccuggg uccaucuugg                                                   20


<210>  11532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11532
uaccccucuc ccuccugggu                                                   20


<210>  11533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11533
cucguacccc ucucccuccu                                                   20


<210>  11534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11534
aaggacagac cggggcgcgc                                                   20


<210>  11535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11535
ggaaagucag gcccuucuuc                                                   20


<210>  11536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11536
cccggccgcg ccggaugcgg                                                   20


<210>  11537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11537
cccgccccca acucccccgg                                                   20


<210>  11538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11538
cccccgcccc caacuccccc                                                   20


<210>  11539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11539
ccgcucuccc ccgcccccaa                                                   20


<210>  11540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11540
cucgccgcuc ucccccgccc                                                   20


<210>  11541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11541
caucccuccc ucgccgcucu                                                   20


<210>  11542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11542
ccacccccuc gcaucccucc                                                   20


<210>  11543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11543
ccccaccccc ucgcaucccu                                                   20


<210>  11544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11544
cucuccccac ccccucgcau                                                   20


<210>  11545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11545
cccaccccgg cacguugcgc                                                   20


<210>  11546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11546
auuuaugauu cuuacuuuaa                                                   20


<210>  11547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11547
cgccuuucuu ucccuugcug                                                   20


<210>  11548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11548
cgcugacugc gccuggaaag                                                   20


<210>  11549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11549
uauacagacu cacaagaacc                                                   20


<210>  11550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11550
caagaaccuc agaccaagcc                                                   20


<210>  11551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11551
gaccaagcca ggccugggga                                                   20


<210>  11552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11552
uccccaggcc uggcuugguc                                                   20


<210>  11553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11553
gggucccagg auccagcgcc                                                   20


<210>  11554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11554
aacacacuuc uccccugccc                                                   20


<210>  11555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11555
ccugcccuuc cccggcaacc                                                   20


<210>  11556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11556
gggcgcaggg ggacugguga                                                   20


<210>  11557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11557
ucgcgguccc gagcugugga                                                   20


<210>  11558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11558
cggucccgag cuguggacaa                                                   20


<210>  11559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11559
ggaccgcgag gaggucacca                                                   20


<210>  11560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11560
uguccacagc ucgggaccgc                                                   20


<210>  11561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11561
gacgucucuu guccacagcu                                                   20


<210>  11562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11562
gcccugggua cuuucucaga                                                   20


<210>  11563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11563
ccuccgcccu ggguacuuuc                                                   20


<210>  11564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11564
ccuccccucc gcccugggua                                                   20


<210>  11565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11565
gcuuugcaaa gcauuuuuau                                                   20


<210>  11566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11566
cagacugcga aaucggcugg                                                   20


<210>  11567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11567
accucccaga cugcgaaauc                                                   20


<210>  11568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11568
ucucgaccuc ccagacugcg                                                   20


<210>  11569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11569
gcauugugcu gggggcggac                                                   20


<210>  11570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11570
gcgccagccu ggcccguggu                                                   20


<210>  11571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11571
ccgcgcccca gcccagcccc                                                   20


<210>  11572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11572
cccgggccuu gcccgaccuc                                                   20


<210>  11573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11573
ggggcugccg cgccgcgcuc                                                   20


<210>  11574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11574
guccucuguc uguuuguugg                                                   20


<210>  11575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11575
gucuguuugu uggcaggagg                                                   20


<210>  11576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11576
ugccaacaaa cagacagagg                                                   20


<210>  11577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11577
cgcacacgcg gugcuuguaa                                                   20


<210>  11578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11578
ugucugaaug uuuacaagca                                                   20


<210>  11579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11579
uacuauuuuu uggaagauuu                                                   20


<210>  11580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11580
ucuuacuauu uuuuggaaga                                                   20


<210>  11581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11581
cuccucuuac uauuuuuugg                                                   20


<210>  11582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11582
cucccucucc gugccgucgg                                                   20


<210>  11583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11583
cccucuccgu gccgucggcg                                                   20


<210>  11584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11584
cucuccgugc cgucggcgcc                                                   20


<210>  11585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11585
ccgugccguc ggcgcccuaa                                                   20


<210>  11586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11586
gugccgucgg cgcccuaagu                                                   20


<210>  11587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11587
ucccccaaac cccuucaguu                                                   20


<210>  11588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11588
ucuagaaaaa aauuuacaau                                                   20


<210>  11589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11589
caucuagaaa aaaauuuaca                                                   20


<210>  11590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11590
caaucucuca ucuagaaaaa                                                   20


<210>  11591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11591
cccaccagcc ccccugcaaa                                                   20


<210>  11592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11592
uugacucccc caccagcccc                                                   20


<210>  11593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11593
gccaacccuu uucugugacg                                                   20


<210>  11594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11594
ugccuuguuu uauuuauuuu                                                   20


<210>  11595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11595
uugcugccuc ugagguucgg                                                   20


<210>  11596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11596
gagguucggu cgggagggga                                                   20


<210>  11597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11597
gaggcagcaa ggagaagacu                                                   20


<210>  11598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11598
cgaccgaacc ucagaggcag                                                   20


<210>  11599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11599
ccucccgacc gaaccucaga                                                   20


<210>  11600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11600
uggguugccg cugcccuccc                                                   20


<210>  11601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11601
cucccucccu cucccgcgug                                                   20


<210>  11602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11602
cucccucucc cgcgugcccc                                                   20


<210>  11603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11603
cucucccgcg ugcccccggc                                                   20


<210>  11604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11604
cccgcgugcc cccggccgcc                                                   20


<210>  11605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11605
cgcgugcccc cggccgccuc                                                   20


<210>  11606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11606
ucccccggcc cuagcuccug                                                   20


<210>  11607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11607
cccggcccua gcuccugccc                                                   20


<210>  11608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11608
ugcccuucgg cggcggcggc                                                   20


<210>  11609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11609
cgcgccgccg ccgccgccgc                                                   20


<210>  11610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11610
cgcuugcccu cccgcgccgc                                                   20


<210>  11611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11611
ucgcgcuugc ccucccgcgc                                                   20


<210>  11612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11612
ggccggaaca aaaggcggca                                                   20


<210>  11613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11613
cguccuuccc ggucccacgg                                                   20


<210>  11614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11614
ccccgucgcc gcggccccuc                                                   20


<210>  11615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11615
ccgucgccgc ggccccucuc                                                   20


<210>  11616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11616
cccgacuccg cggacucagg                                                   20


<210>  11617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11617
cgacuccgcg gacucaggag                                                   20


<210>  11618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11618
gcggacucag gagcgccggg                                                   20


<210>  11619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11619
ggagcgccgg gggccccuuu                                                   20


<210>  11620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11620
ugaguccgcg gagucgggag                                                   20


<210>  11621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11621
cuauuguggg gaugacuacu                                                   20


<210>  11622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11622
cgcugcacac uugaccguga                                                   20


<210>  11623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11623
cggucaagug ugcagcggga                                                   20


<210>  11624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11624
ccucuuuucu ccccgggaau                                                   20


<210>  11625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11625
uuucuccccg ggaaucguuu                                                   20


<210>  11626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11626
ccgggaaucg uuuuuuagac                                                   20


<210>  11627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11627
cucccucccu acccccccau                                                   20


<210>  11628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11628
cucccuaccc ccccauuuuc                                                   20


<210>  11629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11629
cuaccccccc auuuucuuac                                                   20


<210>  11630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11630
ccguaagaaa augggggggu                                                   20


<210>  11631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11631
cuuuccccac cagcucccac                                                   20


<210>  11632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11632
cacccccagg uuugcaugug                                                   20


<210>  11633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11633
caugcaaacc uggggguggg                                                   20


<210>  11634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11634
ccccccgccc cgccaguuuu                                                   20


<210>  11635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11635
uuucgaaaag gaaugcaaug                                                   20


<210>  11636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11636
uuuccgccgc uuuauuucuc                                                   20


<210>  11637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11637
uuccuccuuu ccgccgcuuu                                                   20


<210>  11638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11638
ucuuuccucc uuuccgccgc                                                   20


<210>  11639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11639
uccucuuucc uccuuuccgc                                                   20


<210>  11640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11640
aaagugcaua cacggcaaug                                                   20


<210>  11641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11641
ucccaucugg aaccauugcc                                                   20


<210>  11642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11642
uuuaccucga cucucggagg                                                   20


<210>  11643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11643
acucucggag guuuuucucg                                                   20


<210>  11644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11644
cggagguuuu ucucgugaaa                                                   20


<210>  11645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11645
gagguuuuuc ucgugaaaaa                                                   20


<210>  11646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11646
gagagucgag guaaaagaga                                                   20


<210>  11647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11647
ugaaaaauuu aaaaaugcau                                                   20


<210>  11648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11648
cucccccucg cuuuugcuuc                                                   20


<210>  11649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11649
cccccucgcu uuugcuucua                                                   20


<210>  11650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11650
cccucgcuuu ugcuucuagu                                                   20


<210>  11651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11651
cuuuugcuuc uaguccugcg                                                   20


<210>  11652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11652
cgugauuauu aauaauuauu                                                   20


<210>  11653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11653
ugauuauuaa uaauuauuau                                                   20


<210>  11654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11654
cguaaguaac ccaauaauag                                                   20


<210>  11655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11655
ccgcaagcaa ggcaaacccc                                                   20


<210>  11656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11656
guucacaucg ggagagccgg                                                   20


<210>  11657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11657
cgaugugaac cgagccgucg                                                   20


<210>  11658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11658
cccgauguga accgagccgu                                                   20


<210>  11659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11659
uucuuucuaa cccggcucuc                                                   20


<210>  11660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11660
agagaaaaua ucuucaucag                                                   20


<210>  11661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11661
ggagucuccu ucuuucuaac                                                   20


<210>  11662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11662
cacaauucau cuucccugcg                                                   20


<210>  11663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11663
cccacaauuc aucuucccug                                                   20


<210>  11664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11664
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  11665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11665
cucuuuuuuu uuuuuuuuuu                                                   20


<210>  11666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11666
cccucuuuuu uuuuuuuuuu                                                   20


<210>  11667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11667
cucccucuuu uuuuuuuuuu                                                   20


<210>  11668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11668
cucucccucu uuuuuuuuuu                                                   20


<210>  11669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11669
cucucucccu cuuuuuuuuu                                                   20


<210>  11670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11670
ucucucucuc ucccucuuuu                                                   20


<210>  11671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11671
cuucucucuc ucucccucuu                                                   20


<210>  11672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11672
aucucucuuc ucucucucuc                                                   20


<210>  11673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11673
cucuaucucu cuucucucuc                                                   20


<210>  11674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11674
cccucuaucu cucuucucuc                                                   20


<210>  11675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11675
cucccucuau cucucuucuc                                                   20


<210>  11676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11676
cucucccucu aucucucuuc                                                   20


<210>  11677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11677
cucucucccu cuaucucucu                                                   20


<210>  11678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11678
cucucucucc cucuaucucu                                                   20


<210>  11679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11679
cucucucucu cccucuaucu                                                   20


<210>  11680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11680
cucucucucu cucccucuau                                                   20


<210>  11681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11681
ggggggcuuu ugccauuuuu                                                   20


<210>  11682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11682
ugacguucaa guucgcaggg                                                   20


<210>  11683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11683
guccauccag acuccugacg                                                   20


<210>  11684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11684
cccugcccau guuuugugug                                                   20


<210>  11685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11685
ugcucgcccu gcccauguuu                                                   20


<210>  11686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11686
ccugcucgcc cugcccaugu                                                   20


<210>  11687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11687
ccuucucucc ugcucgcccu                                                   20


<210>  11688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11688
uccccuucuc uccugcucgc                                                   20


<210>  11689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11689
caccaaugga cacacaucag                                                   20


<210>  11690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11690
uuuucauguc cagccccuga                                                   20


<210>  11691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11691
ccgcacuggc cauuggcuug                                                   20


<210>  11692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11692
cccuccccgc acuggccauu                                                   20


<210>  11693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11693
gcggacgcca gacgcggccc                                                   20


<210>  11694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11694
cccgggggcc gcgucuggcg                                                   20


<210>  11695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11695
gcccgccccu cccccggggg                                                   20


<210>  11696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11696
ccucggcccg ccccuccccc                                                   20


<210>  11697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11697
ccaguggccg cagcgagcgc                                                   20


<210>  11698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11698
cugcggccac uggugagccc                                                   20


<210>  11699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11699
cggccacgcc accgccgcgg                                                   20


<210>  11700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11700
cccggccacg ccaccgccgc                                                   20


<210>  11701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11701
caccccugcc accccuuucu                                                   20


<210>  11702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11702
cccccacccu uuccucccac                                                   20


<210>  11703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11703
cccccacaca cgcggacucu                                                   20


<210>  11704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11704
aaaaugaaag auuauucaaa                                                   20


<210>  11705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11705
auuuuuuucu uuuuugaaua                                                   20


<210>  11706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11706
cucuauuuuu uucuuuuuug                                                   20


<210>  11707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11707
cgcucuauuu uuuucuuuuu                                                   20


<210>  11708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11708
cggugcacuc ucgcucuauu                                                   20


<210>  11709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11709
gcccgcgcuu ccccagcccg                                                   20


<210>  11710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11710
accuggcuuc ccuccgcccg                                                   20


<210>  11711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11711
cggacacccu ccuccguacg                                                   20


<210>  11712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11712
uccguacgca cacccacuuc                                                   20


<210>  11713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11713
guacgcacac ccacuucccc                                                   20


<210>  11714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11714
ccgccgccgc cgcgcucgcu                                                   20


<210>  11715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11715
cuccccgcgu guggacgcca                                                   20


<210>  11716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11716
ccgcgugugg acgccagggg                                                   20


<210>  11717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11717
gggcuuuuac uucggccccu                                                   20


<210>  11718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11718
ggaaacuuug cccgaggaga                                                   20


<210>  11719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11719
ggcaaaguuu cccgagcgca                                                   20


<210>  11720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11720
ucgggcaaag uuucccgagc                                                   20


<210>  11721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11721
ccucgggcaa aguuucccga                                                   20


<210>  11722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11722
acuucgggug auuuuucuuu                                                   20


<210>  11723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11723
caacuucggg ugauuuuucu                                                   20


<210>  11724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11724
gcucucaacu ucgggugauu                                                   20


<210>  11725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11725
aaguuacagc uccgcagcgg                                                   20


<210>  11726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11726
gcagcgggcg aggggaggug                                                   20


<210>  11727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11727
cccgcugcgg agcuguaacu                                                   20


<210>  11728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11728
ccucgcccgc ugcggagcug                                                   20


<210>  11729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11729
caccuccccu cgcccgcugc                                                   20


<210>  11730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11730
cucccaccuc cccucgcccg                                                   20


<210>  11731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11731
aaacuuaggc uggauuccgc                                                   20


<210>  11732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11732
aggagcccgc gcggccugga                                                   20


<210>  11733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11733
uggagacuug ggcgcugccc                                                   20


<210>  11734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11734
uuccaggccg cgcgggcucc                                                   20


<210>  11735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11735
ccgguccccu cuuuccaggc                                                   20


<210>  11736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11736
ccccgguccc cucuuuccag                                                   20


<210>  11737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11737
ggccccggcc ugcgccgccu                                                   20


<210>  11738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11738
gccuuggggg cgcccucggg                                                   20


<210>  11739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11739
gauucccggu cccuggcucg                                                   20


<210>  11740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11740
gcgcuuucag uugcauucag                                                   20


<210>  11741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11741
uaagggucgc agaaagagag                                                   20


<210>  11742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11742
uucugcgacc cuuaggagcc                                                   20


<210>  11743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11743
cuuucugcga cccuuaggag                                                   20


<210>  11744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11744
ggcucucuuu cugcgacccu                                                   20


<210>  11745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11745
uucuuuauuc cucgggcucu                                                   20


<210>  11746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11746
ucguucuuua uuccucgggc                                                   20


<210>  11747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11747
ggcuccucgu ucuuuauucc                                                   20


<210>  11748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11748
gggggccaga cucuggcucc                                                   20


<210>  11749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11749
ccuccggggg ccagacucug                                                   20


<210>  11750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11750
ugcccaggcc cccggcgcuc                                                   20


<210>  11751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11751
cuugcccagg cccccggcgc                                                   20


<210>  11752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11752
gugccucucu ugcccaggcc                                                   20


<210>  11753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11753
cugagaggcc gaggacaaag                                                   20


<210>  11754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11754
gagaggccga ggacaaagcg                                                   20


<210>  11755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11755
gagaggugga cgccucggug                                                   20


<210>  11756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11756
cagagaggug gacgccucgg                                                   20


<210>  11757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11757
gccucucaga gagguggacg                                                   20


<210>  11758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11758
cgggacugcc cgcgcuuugu                                                   20


<210>  11759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11759
cggcgccgcg ggaggucccc                                                   20


<210>  11760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11760
cgcggcgccg ugagcacauu                                                   20


<210>  11761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11761
gggaccuccc gcggcgccgu                                                   20


<210>  11762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11762
cagggacccg gcucggggac                                                   20


<210>  11763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11763
cacuccagag caacugcaaa                                                   20


<210>  11764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11764
agagcaacug caaaagcaca                                                   20


<210>  11765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11765
ggagugggag gggguguguc                                                   20


<210>  11766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11766
gugcuuuugc aguugcucug                                                   20


<210>  11767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11767
gcccguaaga aacauuuucu                                                   20


<210>  11768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11768
uucccugggu aacagcacag                                                   20


<210>  11769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11769
auucccauuu ucucuuuccc                                                   20


<210>  11770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11770
ccauucccau uuucucuuuc                                                   20


<210>  11771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11771
cuccauuccc auuuucucuu                                                   20


<210>  11772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11772
cucuccauuc ccauuuucuc                                                   20


<210>  11773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11773
caggagcagc ggggagacca                                                   20


<210>  11774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11774
ugcgagccug ucgcucucuc                                                   20


<210>  11775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11775
ccgcugcucc ugcgagccug                                                   20


<210>  11776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11776
ccaccguggu cuccccgcug                                                   20


<210>  11777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11777
ggucaccgcc gcgcucccca                                                   20


<210>  11778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11778
ccaggcgccg ccggccaagg                                                   20


<210>  11779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11779
ugggugugcg ccuuggccgg                                                   20


<210>  11780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11780
cgccuuucug cagacguucc                                                   20


<210>  11781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11781
ccuuucugca gacguucccu                                                   20


<210>  11782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11782
uuaaugcaca cacgcacaca                                                   20


<210>  11783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11783
ggcgugggau acuuucaguu                                                   20


<210>  11784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11784
cgccucccag ccucccugcc                                                   20


<210>  11785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11785
cagccucccu gccugccagc                                                   20


<210>  11786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11786
cugccugcca gcaccacucu                                                   20


<210>  11787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11787
gcagccgccg ccgccgccgc                                                   20


<210>  11788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11788
ccggcggcgg cggcggcggc                                                   20


<210>  11789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11789
uuccagauuu ggaaucggac                                                   20


<210>  11790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11790
ccccaacucc uuccagauuu                                                   20


<210>  11791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11791
ccccccaacu ccuuccagau                                                   20


<210>  11792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11792
ucucccccca acuccuucca                                                   20


<210>  11793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11793
gguccaaggg aggugcggag                                                   20


<210>  11794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11794
cuuggaccug aguccauucu                                                   20


<210>  11795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11795
gcaccucccu uggaccugag                                                   20


<210>  11796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11796
acccugcacc cuccgcaccu                                                   20


<210>  11797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11797
cgggccaugg cgacccgucu                                                   20


<210>  11798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11798
gggucucgcg ggccauggcg                                                   20


<210>  11799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11799
cacauaucca ccugcagcuc                                                   20


<210>  11800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11800
gcagacacac ucacacauau                                                   20


<210>  11801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11801
cucugcagac acacucacac                                                   20


<210>  11802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11802
ucgcucugca gacacacuca                                                   20


<210>  11803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11803
uucccucucc ucggagcggu                                                   20


<210>  11804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11804
ccucggagcg guuccacaac                                                   20


<210>  11805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11805
ucggagcggu uccacaaccc                                                   20


<210>  11806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11806
gagcgguucc acaacccccg                                                   20


<210>  11807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11807
gaggagaggg aaggagggcu                                                   20


<210>  11808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11808
ucccccucuu cagucuaaag                                                   20


<210>  11809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11809
ucagucuaaa gggugucgcu                                                   20


<210>  11810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11810
cccacccggu gggggggcuu                                                   20


<210>  11811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11811
cuuaaaacaa uaaagccccc                                                   20


<210>  11812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11812
cccaucccgc agcccugccg                                                   20


<210>  11813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11813
gcggagcuuc ggaccccucu                                                   20


<210>  11814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11814
gccgagcuag gcaagccagu                                                   20


<210>  11815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11815
aaggaagaaa aggagguuuu                                                   20


<210>  11816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11816
uuuucuuccu uagagggguc                                                   20


<210>  11817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11817
acauugagag agaugugggc                                                   20


<210>  11818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11818
auguugagca ucaaaaccuc                                                   20


<210>  11819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11819
caauguugag caucaaaacc                                                   20


<210>  11820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11820
cucaauguug agcaucaaaa                                                   20


<210>  11821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11821
aguuuguggg agggagaccu                                                   20


<210>  11822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11822
cacaaacugg agggaaacaa                                                   20


<210>  11823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11823
cucccacaaa cuggagggaa                                                   20


<210>  11824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11824
aauucuguuu aagaagcggg                                                   20


<210>  11825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11825
cgcuucuuaa acagaauuug                                                   20


<210>  11826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11826
guagcuugug ugugacacca                                                   20


<210>  11827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11827
gugaaaaggg gaaauggugu                                                   20


<210>  11828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11828
gaagaacuca gugaaaaggg                                                   20


<210>  11829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11829
auuccaccac agucugcuuu                                                   20


<210>  11830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11830
aaggcugguu uaacaagaca                                                   20


<210>  11831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11831
cccgccaccc cccaagaaga                                                   20


<210>  11832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11832
aaccgucccc cacgucgucc                                                   20


<210>  11833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11833
ucaccuuccc uccaaccguc                                                   20


<210>  11834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11834
cuucaccuuc ccuccaaccg                                                   20


<210>  11835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11835
caguugcacu uucuucuucc                                                   20


<210>  11836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11836
cuauuguuac cugaaggggc                                                   20


<210>  11837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11837
auagauggac uuuuauggac                                                   20


<210>  11838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11838
uuuauauauc uucucuauag                                                   20


<210>  11839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11839
cucauuuaua uaucuucucu                                                   20


<210>  11840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11840
cucgcucauu uauauaucuu                                                   20


<210>  11841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11841
gaaagguucu gugguucaca                                                   20


<210>  11842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11842
gacgauggca cccuaucagg                                                   20


<210>  11843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11843
uuuggcaccc agggaaagca                                                   20


<210>  11844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11844
ccuuuggcac ccagggaaag                                                   20


<210>  11845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11845
gcucccgccc cucccccagc                                                   20


<210>  11846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11846
cgccccuccc ccagccagau                                                   20


<210>  11847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11847
cccagccaga uuucacccag                                                   20


<210>  11848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11848
uggucgucga ccccccuccc                                                   20


<210>  11849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11849
ccggccccug gugcccuccc                                                   20


<210>  11850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11850
ccuagggcga caaccccucc                                                   20


<210>  11851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11851
cucagcacug cuggaugcuc                                                   20


<210>  11852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11852
gcacugcugg augcucgcua                                                   20


<210>  11853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11853
cuaaagagcc cgaaaguggg                                                   20


<210>  11854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11854
uuagcgagca uccagcagug                                                   20


<210>  11855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11855
cccacuuucg ggcucuuuag                                                   20


<210>  11856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11856
ccucccccac uuucgggcuc                                                   20


<210>  11857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11857
uaaaacgaca caucuuucuu                                                   20


<210>  11858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11858
acaaaaccac cugcaucauu                                                   20


<210>  11859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11859
acagccccaa acgaaguuaa                                                   20


<210>  11860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11860
cauugaaagg guaauuacgu                                                   20


<210>  11861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11861
uucccaaacc uuuggugacg                                                   20


<210>  11862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11862
aggccagcag acgaccccuc                                                   20


<210>  11863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11863
ccuucccucc ucccccuuuu                                                   20


<210>  11864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11864
ucccccuuuu uaucuugccc                                                   20


<210>  11865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11865
cccuuuuuau cuugcccgcg                                                   20


<210>  11866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11866
gcgggcaaga uaaaaagggg                                                   20


<210>  11867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11867
uccgcgggca agauaaaaag                                                   20


<210>  11868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11868
gaucuccgua cuuaauagcc                                                   20


<210>  11869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11869
guacuuaaua gccaaguccu                                                   20


<210>  11870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11870
aaaaauacgg uggguuucua                                                   20


<210>  11871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11871
acucuaaaaa uacggugggu                                                   20


<210>  11872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11872
cugcauuagg guauagaucu                                                   20


<210>  11873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11873
cacugcauua ggguauagau                                                   20


<210>  11874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11874
cucacugcau uaggguauag                                                   20


<210>  11875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11875
uacuucauac cgaaaacuac                                                   20


<210>  11876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11876
agacguaacc uuuuagaaaa                                                   20


<210>  11877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11877
agggcucuga acgugaaugu                                                   20


<210>  11878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11878
gaacgugaau guggucaaca                                                   20


<210>  11879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11879
aagagggaga cuuaauacag                                                   20


<210>  11880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11880
ucgagcuguu uguugaccac                                                   20


<210>  11881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11881
cucuucgagc uguuuguuga                                                   20


<210>  11882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11882
gaccgaggau cgccuggcgc                                                   20


<210>  11883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11883
guccgagggc ugggacugua                                                   20


<210>  11884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11884
cgccaggcga uccucggucc                                                   20


<210>  11885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11885
ggcugagcug gaagaugaag                                                   20


<210>  11886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11886
gcccgaguuc cucgcgccag                                                   20


<210>  11887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11887
aagauaaaua agugaaugac                                                   20


<210>  11888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11888
auuuugugac cugccaauua                                                   20


<210>  11889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11889
augauggaag ugcuaggcug                                                   20


<210>  11890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11890
caccuguaau cccagcacuu                                                   20


<210>  11891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11891
gcuucccaaa gugcugggau                                                   20


<210>  11892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11892
caccucggcu ucccaaagug                                                   20


<210>  11893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11893
agugauccuc ccaccucggc                                                   20


<210>  11894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11894
ugaccucaag ugauccuccc                                                   20


<210>  11895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11895
acuaaaaaua caaaaaauug                                                   20


<210>  11896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11896
gcaauuuuuu guauuuuuag                                                   20


<210>  11897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11897
caaguaggug ggacuacaag                                                   20


<210>  11898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11898
gccucccaag uaggugggac                                                   20


<210>  11899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11899
gucccccagg uucaagcgau                                                   20


<210>  11900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11900
cugcaaccuc ugucccccag                                                   20


<210>  11901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11901
agcccgggca acagccuguc                                                   20


<210>  11902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11902
aaaaaauaau aauaaaaaug                                                   20


<210>  11903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11903
cuaacauuuu uauuauuauu                                                   20


<210>  11904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11904
uccacaagca acucccuaac                                                   20


<210>  11905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11905
uccucuucca caagcaacuc                                                   20


<210>  11906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11906
ucuacuccca gugugaccca                                                   20


<210>  11907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11907
acucccagug ugacccacag                                                   20


<210>  11908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11908
cagugugacc cacagguugg                                                   20


<210>  11909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11909
caaccugugg gucacacugg                                                   20


<210>  11910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11910
agggaccucc caaccugugg                                                   20


<210>  11911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11911
caaggaggcu ccugggagaa                                                   20


<210>  11912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11912
aggaggcucc ugggagaacc                                                   20


<210>  11913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11913
uugagagaug ucugugccuu                                                   20


<210>  11914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11914
ugggagaacc auuagucugg                                                   20


<210>  11915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11915
caggagccuc cuugagagau                                                   20


<210>  11916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11916
ccaggcuccc ugggccuuua                                                   20


<210>  11917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11917
aggcucccug ggccuuuagc                                                   20


<210>  11918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11918
cugggccuuu agcuagcuag                                                   20


<210>  11919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11919
uuccuuccuu ucuuccuucu                                                   20


<210>  11920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11920
cuccuuccuu ccuuucuucc                                                   20


<210>  11921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11921
cucccuccuu ccuuccuuuc                                                   20


<210>  11922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11922
cucccucccu ccuuccuucc                                                   20


<210>  11923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11923
cucccucccu cccuccuucc                                                   20


<210>  11924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11924
cucccucccu cccucccucc                                                   20


<210>  11925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11925
uuucuuucuu ucuuccuucc                                                   20


<210>  11926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11926
cuccuuucuu ucuuucuucc                                                   20


<210>  11927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11927
cuuccucccu ccuuucuuuc                                                   20


<210>  11928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11928
cucccuuccu cccuccuuuc                                                   20


<210>  11929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11929
cucccucccu uccucccucc                                                   20


<210>  11930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11930
uuccuuccuc ccucccuccc                                                   20


<210>  11931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11931
cuccuuccuu ccucccuccc                                                   20


<210>  11932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11932
aagucuauac uuuccucuag                                                   20


<210>  11933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11933
agaugaggcu gcugugugcu                                                   20


<210>  11934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11934
ucuagaggaa aguauagacu                                                   20


<210>  11935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11935
uccccauaca uuauugacuu                                                   20


<210>  11936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11936
cucuucccca uacauuauug                                                   20


<210>  11937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11937
uccaaggggc cccuuacuua                                                   20


<210>  11938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11938
uugucucuuc caaggggccc                                                   20


<210>  11939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11939
guuuagcuuc cuaauauuga                                                   20


<210>  11940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11940
gugucuuuga ugucaauauu                                                   20


<210>  11941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11941
agugcaguac auucauugga                                                   20


<210>  11942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11942
cuagugcagu acauucauug                                                   20


<210>  11943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11943
uggaauaggg uugccugauc                                                   20


<210>  11944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11944
ccauccuugg ugggaaucac                                                   20


<210>  11945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11945
gaaaagauua ucucgaauau                                                   20


<210>  11946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11946
aauaucagag cagcugaaca                                                   20


<210>  11947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11947
gauauucgag auaaucuuuu                                                   20


<210>  11948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11948
agcagcauac auuaucaaau                                                   20


<210>  11949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11949
aaugagacua cuuuuaaagg                                                   20


<210>  11950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11950
uuugagaaag caguuuugua                                                   20


<210>  11951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11951
augcuucccu accccaugca                                                   20


<210>  11952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11952
cucuuucccu cucucucgua                                                   20


<210>  11953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11953
cuuucccucu cucucguaaa                                                   20


<210>  11954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11954
uucccucucu cucguaaaua                                                   20


<210>  11955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11955
cucucguaaa uaaaaaaaaa                                                   20


<210>  11956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11956
cucguaaaua aaaaaaaaag                                                   20


<210>  11957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11957
cguaaauaaa aaaaaaagca                                                   20


<210>  11958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11958
uaaauaaaaa aaaaagcaac                                                   20


<210>  11959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11959
cauuguuuua aaucacauug                                                   20


<210>  11960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11960
uaaaauuugg guuuauaaug                                                   20


<210>  11961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11961
uaauuauagc agcccugcca                                                   20


<210>  11962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11962
auaguaauga aagcacaacu                                                   20


<210>  11963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11963
uaaacuuggg guuuauaaua                                                   20


<210>  11964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11964
gcugaggaag cuuuuggauc                                                   20


<210>  11965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11965
gcugaguuau ucugccuuuu                                                   20


<210>  11966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11966
cucucuccuc uuucucucuc                                                   20


<210>  11967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11967
cucuccucuu ucucucucuc                                                   20


<210>  11968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11968
cuccucuuuc ucucucucuc                                                   20


<210>  11969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11969
ccucuuucuc ucucucucuc                                                   20


<210>  11970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11970
ucuuucucuc ucucucucuc                                                   20


<210>  11971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11971
uucucucucu cucucucucu                                                   20


<210>  11972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11972
cucucucucu cucucuccug                                                   20


<210>  11973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11973
cucucucucu cucuccuguu                                                   20


<210>  11974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11974
cucucucucu cuccuguuuc                                                   20


<210>  11975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11975
cucucucucu ccuguuucuc                                                   20


<210>  11976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11976
cucucucucc uguuucucuc                                                   20


<210>  11977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11977
cucucuccug uuucucucuc                                                   20


<210>  11978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11978
cucuccuguu ucucucucuc                                                   20


<210>  11979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11979
cuccuguuuc ucucucucuc                                                   20


<210>  11980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11980
ccuguuucuc ucucucucua                                                   20


<210>  11981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11981
uguuucucuc ucucucuauc                                                   20


<210>  11982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11982
cucucucuau cucuucuguu                                                   20


<210>  11983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11983
cucucuaucu cuucuguuuc                                                   20


<210>  11984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11984
cucuaucucu ucuguuucuc                                                   20


<210>  11985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11985
cuaucucuuc uguuucucuc                                                   20


<210>  11986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11986
aucucuucug uuucucucuc                                                   20


<210>  11987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11987
ucuguuucuc ucucucuccc                                                   20


<210>  11988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11988
cucucucccu cucucuccuc                                                   20


<210>  11989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11989
cucucccucu cucuccucca                                                   20


<210>  11990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11990
cucccucucu cuccuccaga                                                   20


<210>  11991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11991
cccucucucu ccuccagaac                                                   20


<210>  11992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11992
cucucucucc uccagaacau                                                   20


<210>  11993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11993
cucuccucca gaacauuuca                                                   20


<210>  11994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11994
cuccuccaga acauuucaga                                                   20


<210>  11995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11995
ccuccagaac auuucagaau                                                   20


<210>  11996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11996
uccagaacau uucagaaugu                                                   20


<210>  11997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11997
agaacauuuc agaauguuuu                                                   20


<210>  11998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11998
uugcgauuuu auaaguuuuu                                                   20


<210>  11999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  11999
aggauaaaau aauaaaaacu                                                   20


<210>  12000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12000
uacauauaca cagagguaug                                                   20


<210>  12001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12001
guguauaugu augaggucgc                                                   20


<210>  12002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12002
gaucaucuua auccugucua                                                   20


<210>  12003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12003
uauuuuuacc acacaguugg                                                   20


<210>  12004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12004
ggaugacugc accaugcuau                                                   20


<210>  12005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12005
gcuugacuuu gacuguugac                                                   20


<210>  12006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12006
gguccaccgg auuauacaaa                                                   20


<210>  12007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12007
gcaucggcca caucaucacc                                                   20


<210>  12008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12008
ugcauauacu cagcaucggc                                                   20


<210>  12009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12009
aucgccacca ucaucaucau                                                   20


<210>  12010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12010
aucaccauca ccaccaguau                                                   20


<210>  12011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12011
ccaccccauc agcacuaccu                                                   20


<210>  12012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12012
aauuaacaug uccaccagag                                                   20


<210>  12013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12013
gguggacaug uuaauuagag                                                   20


<210>  12014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12014
aacacuuugu uucuccaaau                                                   20


<210>  12015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12015
aaaucuuguu gcuuuagaaa                                                   20


<210>  12016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12016
auaaacauca gguggcggac                                                   20


<210>  12017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12017
uggcaccucc accaaaaugu                                                   20


<210>  12018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12018
accaaaaugu gaccuuggcu                                                   20


<210>  12019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12019
uggugggccu uucuguguga                                                   20


<210>  12020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12020
ucugaaagug aaaagauuuc                                                   20


<210>  12021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12021
auucccucug acugggauca                                                   20


<210>  12022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12022
gacugggauc agaccaccaa                                                   20


<210>  12023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12023
guggccuaau uugguggucu                                                   20


<210>  12024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12024
cuucacaaua gcuuuaguug                                                   20


<210>  12025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12025
ucuggaauuc aaugagugac                                                   20


<210>  12026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12026
ggaauucaau gagugacaaa                                                   20


<210>  12027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12027
uugaauucca gaggagacca                                                   20


<210>  12028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12028
aguuccuucu cuaccagugu                                                   20


<210>  12029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12029
accagugucu cauaaacccc                                                   20


<210>  12030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12030
uaaaccccau aauugccuaa                                                   20


<210>  12031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12031
agcugaaugc cagucauucc                                                   20


<210>  12032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12032
gggaaugacu ggcauucagc                                                   20


<210>  12033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12033
cugggaauga cuggcauuca                                                   20


<210>  12034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12034
agaaauuaag acuuuuuuug                                                   20


<210>  12035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12035
uagaaaaguu cccuuugcug                                                   20


<210>  12036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12036
gucaucuuuc uuuggcagcu                                                   20


<210>  12037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12037
acuaagcugc caaagaaaga                                                   20


<210>  12038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12038
cuauucuccc auucccaguu                                                   20


<210>  12039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12039
auucucccau ucccaguugc                                                   20


<210>  12040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12040
cauucccagu ugcacacaau                                                   20


<210>  12041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12041
uucucuuaaa aaaaaaaaau                                                   20


<210>  12042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12042
uaaaaaaaaa aaauccuugc                                                   20


<210>  12043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12043
agauuccuau aaaaugaaga                                                   20


<210>  12044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12044
auaaagaagg aaagaauaac                                                   20


<210>  12045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12045
aauuaguaau augaagcuag                                                   20


<210>  12046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12046
cuauagguuu agaaccgcuc                                                   20


<210>  12047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12047
cauagauccu cgcuauaggu                                                   20


<210>  12048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12048
ggucacucug acaccagauu                                                   20


<210>  12049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12049
gacaccagau uuguacuuuc                                                   20


<210>  12050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12050
agaaaguaca aaucuggugu                                                   20


<210>  12051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12051
uuuaugggaa aucaaguuuu                                                   20


<210>  12052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12052
uuauuuacca uucucauuua                                                   20


<210>  12053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12053
aucacaguuu uuauaauguu                                                   20


<210>  12054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12054
aaaguaacua guuaagccau                                                   20


<210>  12055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12055
uuucucaaaa guaacuaguu                                                   20


<210>  12056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12056
aaaaaaaaaa aaaggcacau                                                   20


<210>  12057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12057
gacucaaaaa aaaaaaaaag                                                   20


<210>  12058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12058
cucuuucacc ucuggaaugc                                                   20


<210>  12059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12059
uucaccucug gaaugcagug                                                   20


<210>  12060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12060
ggaaugcagu ggcacaaucu                                                   20


<210>  12061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12061
cugcaacuuc ugccuccagg                                                   20


<210>  12062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12062
agguucaagc aauucucccu                                                   20


<210>  12063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12063
cucccucaac cuccugagua                                                   20


<210>  12064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12064
cucaaccucc ugaguagcug                                                   20


<210>  12065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12065
accuccugag uagcugggau                                                   20


<210>  12066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12066
ugaguagcug ggauuacagg                                                   20


<210>  12067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12067
ggagguugag ggagggagaa                                                   20


<210>  12068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12068
acuaaaaaaa uacaaaaauu                                                   20


<210>  12069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12069
cuacuaaaaa aauacaaaaa                                                   20


<210>  12070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12070
aacuccugac cucacgugau                                                   20


<210>  12071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12071
ugaccucacg ugauccaccc                                                   20


<210>  12072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12072
cgugauccac ccaccucagu                                                   20


<210>  12073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12073
gucucccaaa gugcugggau                                                   20


<210>  12074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12074
caaagugcug ggauuauagg                                                   20


<210>  12075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12075
cgccuauaau cccagcacuu                                                   20


<210>  12076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12076
cuaauaagua cucaauaauu                                                   20


<210>  12077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12077
auaauugaaa auuauauuau                                                   20


<210>  12078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12078
acacccacuu ccaucagggg                                                   20


<210>  12079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12079
cuguguauau uccauauaau                                                   20


<210>  12080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12080
guguauauuc cauauaauau                                                   20


<210>  12081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12081
aacaacuuag gacuugggug                                                   20


<210>  12082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12082
gucauuuuca ucuuucucuc                                                   20


<210>  12083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12083
cccucagcac agaguagaac                                                   20


<210>  12084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12084
cucagcacag aguagaaccu                                                   20


<210>  12085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12085
gcacagagua gaaccuuagg                                                   20


<210>  12086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12086
gugcugaggg agagaaagau                                                   20


<210>  12087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12087
auucucagau uuugaaaugc                                                   20


<210>  12088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12088
gauuuugaaa ugcagcaaaa                                                   20


<210>  12089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12089
ugaaauuugg cuguuugaau                                                   20


<210>  12090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12090
guuaugaugc ucuugaaauu                                                   20


<210>  12091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12091
gagagacuaa uucuggaggc                                                   20


<210>  12092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12092
gaguuacucu guuaugaugc                                                   20


<210>  12093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12093
cagaguuacu cuguuaugau                                                   20


<210>  12094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12094
agaauuaguc ucucagaguu                                                   20


<210>  12095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12095
agacacuacg uucuuuaaau                                                   20


<210>  12096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12096
cagagcuuua uaugggcaac                                                   20


<210>  12097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12097
gugagcuuug ccuguugcaa                                                   20


<210>  12098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12098
gggagcaagg gaaauaucag                                                   20


<210>  12099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12099
cugagccagg ccagaaaaaa                                                   20


<210>  12100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12100
ugacauauga ugaguaaaga                                                   20


<210>  12101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12101
ucauauguca agagcauaua                                                   20


<210>  12102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12102
ucucaaaaua uugaaucuug                                                   20


<210>  12103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12103
aaauauugaa ucuugaacuc                                                   20


<210>  12104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12104
gagcuuaauu aguggauuuu                                                   20


<210>  12105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12105
gaguucaaga uucaauauuu                                                   20


<210>  12106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12106
uuuuaaaaca uguuuuauaa                                                   20


<210>  12107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12107
ccuucauggg aacaugcagc                                                   20


<210>  12108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12108
uucaugggaa caugcagcuu                                                   20


<210>  12109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12109
guuugauuua uuuaugcuaa                                                   20


<210>  12110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12110
aaccaaaaag gaacuccuuu                                                   20


<210>  12111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12111
uuucuuuuaa aaaaaaauua                                                   20


<210>  12112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12112
uuaacuuaau gugaccaaga                                                   20


<210>  12113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12113
guauuuaaau uucuuucuug                                                   20


<210>  12114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12114
guaagauuga caugauaucu                                                   20


<210>  12115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12115
uuccuaaaaa aauuaauaaa                                                   20


<210>  12116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12116
cauuccuaaa aaaauuaaua                                                   20


<210>  12117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12117
ggauuaauau uuguuuccug                                                   20


<210>  12118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12118
ggccggggaa auuuucacug                                                   20


<210>  12119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12119
gcuuguuacu cuggccgggg                                                   20


<210>  12120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12120
cugcuuguua cucuggccgg                                                   20


<210>  12121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12121
guguaacauu aggugaucuc                                                   20


<210>  12122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12122
caguguaaca uuaggugauc                                                   20


<210>  12123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12123
uaucacccau uagucaccac                                                   20


<210>  12124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12124
aguauuauug auagcacaua                                                   20


<210>  12125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12125
ugauuuugau aggcauuugc                                                   20


<210>  12126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12126
gcaucuuacc cuuucuaugc                                                   20


<210>  12127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12127
uucuuauuuu aucacaaguc                                                   20


<210>  12128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12128
cuguaucuuc accagaaccu                                                   20


<210>  12129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12129
gaauuagagc uucagucuca                                                   20


<210>  12130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12130
aauucugagu cauccugcuu                                                   20


<210>  12131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12131
uccucccuga auguuccugu                                                   20


<210>  12132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12132
cugaauguuc cuguguccaa                                                   20


<210>  12133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12133
uuaguuggug auacuuggac                                                   20


<210>  12134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12134
cacuaaacug aaaccccugg                                                   20


<210>  12135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12135
cuaaacugaa accccuggug                                                   20


<210>  12136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12136
agaccaaggu gcaguuaaug                                                   20


<210>  12137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12137
accucaagac caaggugcag                                                   20


<210>  12138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12138
accaaaaguc agcaucauaa                                                   20


<210>  12139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12139
ugaaaaccac uccaccaaaa                                                   20


<210>  12140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12140
cuugaaaacc acuccaccaa                                                   20


<210>  12141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12141
gcuugcucuc uugaaaacca                                                   20


<210>  12142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12142
ggccuguuug guucuggaug                                                   20


<210>  12143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12143
uuguggaagc uguccauggu                                                   20


<210>  12144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12144
gagccaauaa aaaugaaacu                                                   20


<210>  12145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12145
gaguuccaag gauaccuuug                                                   20


<210>  12146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12146
ucugagaccu aauuaacuuu                                                   20


<210>  12147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12147
gaagagaaua guuucauuuu                                                   20


<210>  12148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12148
ucauaagcaa agaacaaaug                                                   20


<210>  12149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12149
ccuguaagga auuuucuguu                                                   20


<210>  12150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12150
aaagaacaga aaauuccuua                                                   20


<210>  12151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12151
aaacauuaag uauuuuccua                                                   20


<210>  12152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12152
uauuagucac ugcuccuaua                                                   20


<210>  12153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12153
uauaugaucc uuuuucaugu                                                   20


<210>  12154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12154
uuuaaaacau gaaaaaggau                                                   20


<210>  12155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12155
ugcagguucc ugugauugcu                                                   20


<210>  12156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12156
gaaauuugca uauuuauagu                                                   20


<210>  12157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12157
cagaaauuug cauauuuaua                                                   20


<210>  12158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12158
aaguaguaag ggaaacagga                                                   20


<210>  12159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12159
ggcuuuccug uuucccuuac                                                   20


<210>  12160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12160
uacuuucaag uaauucguau                                                   20


<210>  12161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12161
cuuucuugga caaccuguga                                                   20


<210>  12162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12162
aggaacagcc auaccugagu                                                   20


<210>  12163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12163
gguauggcug uuccuggagc                                                   20


<210>  12164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12164
gaacucaggu auggcuguuc                                                   20


<210>  12165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12165
cgucagccac aguuccacuu                                                   20


<210>  12166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12166
accuaaaauc uggaaauuug                                                   20


<210>  12167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12167
aacccuuuaa agaugcaugu                                                   20


<210>  12168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12168
auguaacaug caucuuuaaa                                                   20


<210>  12169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12169
ccaagauccc aaacaccauu                                                   20


<210>  12170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12170
aggaaauucu uaaaacauuu                                                   20


<210>  12171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12171
caaaauuuuc cuuuaauaga                                                   20


<210>  12172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12172
auagucacuc uauuacagau                                                   20


<210>  12173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12173
auuacagauu uucauauuaa                                                   20


<210>  12174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12174
acccauuaga uucugucaug                                                   20


<210>  12175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12175
ucaacccauu agauucuguc                                                   20


<210>  12176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12176
uccucaaccc auuagauucu                                                   20


<210>  12177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12177
gaucaaauca caaaaacugu                                                   20


<210>  12178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12178
gguguacauu aaaaacucua                                                   20


<210>  12179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12179
agauucugag ccaccaaggc                                                   20


<210>  12180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12180
gaaucuagag uuuuuaaugu                                                   20


<210>  12181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12181
acuuuuucug uuagacucac                                                   20


<210>  12182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12182
ccucaaucuu ccccaaggcc                                                   20


<210>  12183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12183
aucuucccca aggccccaca                                                   20


<210>  12184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12184
cuaauuuugc uauuuuuuaa                                                   20


<210>  12185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12185
cuccuaaugu aaacaucuca                                                   20


<210>  12186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12186
ccuaauguaa acaucucacc                                                   20


<210>  12187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12187
uaauguaaac aucucaccgu                                                   20


<210>  12188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12188
ccguggcuac auacugaagu                                                   20


<210>  12189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12189
guacuucuuu uccauauuca                                                   20


<210>  12190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12190
acuuugcugu agcuguaaag                                                   20


<210>  12191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12191
guccuccacu uugcuguagc                                                   20


<210>  12192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12192
uugcugaaau uacauaggua                                                   20


<210>  12193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12193
acacacagga uacaagauuc                                                   20


<210>  12194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12194
gaccugaggg cccacaagga                                                   20


<210>  12195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12195
ggucagagcu caacacacag                                                   20


<210>  12196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12196
uugugggccc ucaggucaga                                                   20


<210>  12197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12197
ccuugugggc ccucagguca                                                   20


<210>  12198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12198
cuuucucucc uugugggccc                                                   20


<210>  12199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12199
cccuuucucu ccuugugggc                                                   20


<210>  12200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12200
cccaaaacuu aaacaagcac                                                   20


<210>  12201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12201
auaugaucag gagaauuuuu                                                   20


<210>  12202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12202
ugaucauaua gagugauggg                                                   20


<210>  12203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12203
agguuuuacu gccacagaag                                                   20


<210>  12204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12204
ucuuucccag aaccccugcc                                                   20


<210>  12205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12205
uucccagaac cccugccaua                                                   20


<210>  12206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12206
gucgcucacc uucuagacac                                                   20


<210>  12207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12207
ccuucuagac acuccguaca                                                   20


<210>  12208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12208
guacaaccau ucaaucuauu                                                   20


<210>  12209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12209
ugauucaaua gauugaaugg                                                   20


<210>  12210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12210
cagaugcaga uaagaucaaa                                                   20


<210>  12211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12211
aaggguuaau aaauuuagaa                                                   20


<210>  12212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12212
ccccaauuau cauaaugaaa                                                   20


<210>  12213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12213
ccccccaauu aucauaauga                                                   20


<210>  12214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12214
cuccccccaa uuaucauaau                                                   20


<210>  12215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12215
ccuaggcuga gguuugccug                                                   20


<210>  12216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12216
uaggcugagg uuugccugug                                                   20


<210>  12217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12217
gccuaggaga gugccuggga                                                   20


<210>  12218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12218
agaaacaguu cagucucuga                                                   20


<210>  12219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12219
gaaaacaaug caaaaggaaa                                                   20


<210>  12220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12220
uuuuccuuuu gcauuguuuu                                                   20


<210>  12221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12221
ucuuuuuccu uuugcauugu                                                   20


<210>  12222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12222
uucccuuucu ucuucccccu                                                   20


<210>  12223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12223
aacagauuuc caauggucca                                                   20


<210>  12224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12224
acaaauuccu ccaguaaguc                                                   20


<210>  12225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12225
aguaagucaa acuucugaau                                                   20


<210>  12226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12226
ccucccccaa agaagaacuc                                                   20


<210>  12227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12227
cccaaagaag aacucuaagc                                                   20


<210>  12228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12228
aagcaauuag aauuauaggu                                                   20


<210>  12229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12229
ccuuuagcag gacuaccuau                                                   20


<210>  12230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12230
ucuacuugcc cauuacugau                                                   20


<210>  12231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12231
cuuuuuuggu aaccacgugc                                                   20


<210>  12232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12232
cuaauguagc cuaauaacaa                                                   20


<210>  12233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12233
aauguagccu aauaacaauu                                                   20


<210>  12234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12234
aaaucaaauc uaauagaaaa                                                   20


<210>  12235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12235
aaggcaccca cuggggcuuc                                                   20


<210>  12236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12236
gccucgaagg cacccacugg                                                   20


<210>  12237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12237
cagauagauc ucugccucga                                                   20


<210>  12238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12238
auagcagccu gggcuaaccu                                                   20


<210>  12239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12239
ggaaagguca agguuagccc                                                   20


<210>  12240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12240
aucuggugcc agccugcuuu                                                   20


<210>  12241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12241
uuuuuugcuu cauagucaac                                                   20


<210>  12242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12242
guucugccuu gaucaauguu                                                   20


<210>  12243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12243
ucuccuggaa gggcugggca                                                   20


<210>  12244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12244
uggaagggcu gggcagacuc                                                   20


<210>  12245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12245
ggagaacagc acauuucagu                                                   20


<210>  12246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12246
ugagucugcc cagcccuucc                                                   20


<210>  12247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12247
uaugcaauca uaaaucuaca                                                   20


<210>  12248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12248
uauguagauu uaugauugca                                                   20


<210>  12249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12249
aaagauuuuu uuucucccuc                                                   20


<210>  12250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12250
cucccaacag ggauuuauaa                                                   20


<210>  12251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12251
caacagggau uuauaagcuc                                                   20


<210>  12252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12252
guaagagcuc ccggacaacg                                                   20


<210>  12253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12253
uacagagcuu auaaaucccu                                                   20


<210>  12254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12254
cggacaacgg cuuuccccaa                                                   20


<210>  12255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12255
aaugcugcaa auucauuuuu                                                   20


<210>  12256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12256
cuggcuuuua ucuaggauuu                                                   20


<210>  12257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12257
acacccaucc ucauuaugca                                                   20


<210>  12258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12258
uuaugcauuu cuagauagau                                                   20


<210>  12259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12259
gaauucugac cccuuuuuua                                                   20


<210>  12260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12260
ugaugguuaa aaaagggguc                                                   20


<210>  12261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12261
ccucuugaug guuaaaaaag                                                   20


<210>  12262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12262
ccccucuuga ugguuaaaaa                                                   20


<210>  12263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12263
uuaucucucc ccucuugaug                                                   20


<210>  12264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12264
cucuuuaucu cuccccucuu                                                   20


<210>  12265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12265
cccucuuuau cucuccccuc                                                   20


<210>  12266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12266
cucccucuuu aucucucccc                                                   20


<210>  12267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12267
ucucucccuc uuuaucucuc                                                   20


<210>  12268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12268
ccucucuccc ucuuuaucuc                                                   20


<210>  12269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12269
gacucuccuc ucucccucuu                                                   20


<210>  12270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12270
uuucucugac ucuccucucu                                                   20


<210>  12271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12271
gugucucuuu ucucugacuc                                                   20


<210>  12272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12272
ucugugucuc uuuucucuga                                                   20


<210>  12273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12273
ccucuguguc ucuuuucucu                                                   20


<210>  12274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12274
cuccucugug ucucuuuucu                                                   20


<210>  12275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12275
guuuggcaug uuuccaucug                                                   20


<210>  12276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12276
cuguuuggca uguuuccauc                                                   20


<210>  12277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12277
cucuguuugg cauguuucca                                                   20


<210>  12278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12278
auucaagugu uacaucguua                                                   20


<210>  12279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12279
ccucccuagg ccacauuccu                                                   20


<210>  12280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12280
ucccuaggcc acauuccucc                                                   20


<210>  12281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12281
cuaggccaca uuccuccuuu                                                   20


<210>  12282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12282
uuucccaaag acccacacga                                                   20


<210>  12283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12283
uucuccagau cacccacuag                                                   20


<210>  12284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12284
agaucaccca cuagaguaca                                                   20


<210>  12285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12285
agugggugau cuggagaagg                                                   20


<210>  12286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12286
ucugccccac acucucuuuc                                                   20


<210>  12287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12287
gccccacacu cucuuucuuu                                                   20


<210>  12288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12288
cuuucuuucc uccucuucuc                                                   20


<210>  12289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12289
uucuuuccuc cucuucucuc                                                   20


<210>  12290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12290
ucuucucucu guaucagggg                                                   20


<210>  12291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12291
ucucucugua ucaggggcug                                                   20


<210>  12292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12292
cuguaucagg ggcugggugg                                                   20


<210>  12293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12293
guaucagggg cuggguggua                                                   20


<210>  12294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12294
uuaccaccca gccccugaua                                                   20


<210>  12295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12295
gucagccucu uuaccaccca                                                   20


<210>  12296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12296
cccucaguca gccucuuuac                                                   20


<210>  12297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12297
aaagaaauug acugacuggc                                                   20


<210>  12298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12298
ggucauuucc auauauugaa                                                   20


<210>  12299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12299
acacuuuguc auuuuucuag                                                   20


<210>  12300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12300
ucuccucaca gaagccucau                                                   20


<210>  12301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12301
ucacagaagc cucauuucuu                                                   20


<210>  12302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12302
cagaagccuc auuucuugca                                                   20


<210>  12303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12303
uuucuugcau uuugccuugc                                                   20


<210>  12304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12304
ucccacuucc aaccuacacc                                                   20


<210>  12305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12305
ccaaaucuug ccccauccuc                                                   20


<210>  12306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12306
aaaucuugcc ccauccucuc                                                   20


<210>  12307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12307
ccaucgcucc caaccaccgc                                                   20


<210>  12308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12308
aucgcuccca accaccgcgc                                                   20


<210>  12309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12309
caaccaccgc gcgcccccac                                                   20


<210>  12310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12310
ggcuccccug uaauuggaaa                                                   20


<210>  12311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12311
ccuguaauug gaaacauccg                                                   20


<210>  12312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12312
gauuaucuga gacaagaggc                                                   20


<210>  12313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12313
gauaauccga ggcagggcag                                                   20


<210>  12314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12314
ugucucagau aauccgaggc                                                   20


<210>  12315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12315
uccugggcgc cucuugucuc                                                   20


<210>  12316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12316
uguaaucccc aggaugggaa                                                   20


<210>  12317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12317
agccccuuau gauaaagaaa                                                   20


<210>  12318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12318
uuccuuaccc cagcccccac                                                   20


<210>  12319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12319
acccucgagg aguucccuua                                                   20


<210>  12320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12320
aggaguuccc uuagcaaacu                                                   20


<210>  12321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12321
aggguggagu gggggcuggg                                                   20


<210>  12322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12322
ucgagggugg agugggggcu                                                   20


<210>  12323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12323
auggcacugc auggcacaag                                                   20


<210>  12324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12324
ccauggcacu gcauggcaca                                                   20


<210>  12325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12325
acacaagaaa agcaggaacc                                                   20


<210>  12326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12326
ggugcccucc accuaacccu                                                   20


<210>  12327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12327
accuaacccu gccccaaugc                                                   20


<210>  12328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12328
ggucuuuuuu gaacuaaugc                                                   20


<210>  12329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12329
gcaaucugca auuacuuugg                                                   20


<210>  12330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12330
ggagcuaaac gcagccugaa                                                   20


<210>  12331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12331
ugagaaauau ccaaaguaau                                                   20


<210>  12332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12332
agaaaaaaac aacagcgcgg                                                   20


<210>  12333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12333
cucccagauc cuacuugaga                                                   20


<210>  12334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12334
cagauccuac uugagaucuc                                                   20


<210>  12335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12335
aguaggaucu gggagggagu                                                   20


<210>  12336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12336
aaucuuucaa cuugggucuc                                                   20


<210>  12337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12337
guuuugccua cugggcagcc                                                   20


<210>  12338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12338
cuuuuuuuuu cuuucucuug                                                   20


<210>  12339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12339
uuuuuuuucu uucucuugga                                                   20


<210>  12340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12340
uggaucuagg aacaauaggc                                                   20


<210>  12341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12341
gaaccuaauu aauuuuauua                                                   20


<210>  12342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12342
aaugguuaau ucccccaggc                                                   20


<210>  12343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12343
acagcgucug cguccucaaa                                                   20


<210>  12344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12344
ggugacucaa cagcgucugc                                                   20


<210>  12345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12345
caucauaagc uuauacuucc                                                   20


<210>  12346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12346
ucacaagguc aaacaaaaac                                                   20


<210>  12347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12347
aauugugcag aaccccggga                                                   20


<210>  12348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12348
cccauucaua guuuguuguc                                                   20


<210>  12349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12349
cacuauuugg aacugguggg                                                   20


<210>  12350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12350
cuauuuggaa cuggugggga                                                   20


<210>  12351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12351
ccaccaguuc caaauaguga                                                   20


<210>  12352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12352
ggugcauccu agaguggaua                                                   20


<210>  12353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12353
aggaugcacc ggagguucac                                                   20


<210>  12354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12354
agagcgaagg aaaauguaac                                                   20


<210>  12355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12355
ugagaaggca uauuggauuu                                                   20


<210>  12356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12356
gguaauuuga aauacauuuu                                                   20


<210>  12357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12357
uggaaaaaac caauuuaaua                                                   20


<210>  12358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12358
uaggaauucu aaugucauag                                                   20


<210>  12359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12359
ugguuuuuuu uuuauauuau                                                   20


<210>  12360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12360
ugaauauuuu aucauaucua                                                   20


<210>  12361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12361
cugaaggaaa augugcuuga                                                   20


<210>  12362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12362
gaaggaaaau gugcuugaaa                                                   20


<210>  12363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12363
uuuauggaau uuguuuugau                                                   20


<210>  12364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12364
guaacaugga agcuaggaag                                                   20


<210>  12365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12365
gccuuguacg gucugagguu                                                   20


<210>  12366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12366
gaccguacaa ggcagagcuu                                                   20


<210>  12367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12367
uuuuuagcug gcaugugcug                                                   20


<210>  12368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12368
cuuauuucua cacucaugua                                                   20


<210>  12369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12369
uguaauuuaa cagguuugga                                                   20


<210>  12370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12370
aaaccuguua aauuacauga                                                   20


<210>  12371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12371
ccaaaccugu uaaauuacau                                                   20


<210>  12372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12372
caacuguugu cauccuaugu                                                   20


<210>  12373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12373
aacaaaaugc acuuuuuguu                                                   20


<210>  12374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12374
cagcuuuuua cagcucccca                                                   20


<210>  12375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12375
ccauggcaau uuucuguacu                                                   20


<210>  12376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12376
cccauaugag acacuuugaa                                                   20


<210>  12377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12377
uaugggggag gggcaguuga                                                   20


<210>  12378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12378
aauucucaga cugcucucug                                                   20


<210>  12379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12379
gacugcucuc ugauggaacu                                                   20


<210>  12380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12380
cugauggaac uaggagaauu                                                   20


<210>  12381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12381
gauggaacua ggagaauugg                                                   20


<210>  12382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12382
uaguuccauc agagagcagu                                                   20


<210>  12383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12383
aauuauuuca cauuuuuauu                                                   20


<210>  12384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12384
aaugggggaa aaccaaaaau                                                   20


<210>  12385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12385
ccucuuuuuu uuuuaugaua                                                   20


<210>  12386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12386
uuuuuuuuua ugauaacaua                                                   20


<210>  12387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12387
ccaagcaguu guugaacuau                                                   20


<210>  12388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12388
aacgugcaau uauuuuuucc                                                   20


<210>  12389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12389
aagucccugg guugauauga                                                   20


<210>  12390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12390
gugucaacua ugucagagac                                                   20


<210>  12391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12391
gacauaguug acaccgagga                                                   20


<210>  12392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12392
gggagugggg agaaaagaaa                                                   20


<210>  12393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12393
cagaggauac uuugaauguu                                                   20


<210>  12394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12394
ccacucccag aggauacuuu                                                   20


<210>  12395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12395
augaacccaa acuuggaggg                                                   20


<210>  12396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12396
aaguuugggu ucauggagac                                                   20


<210>  12397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12397
ucaucuucau ugcuugaauc                                                   20


<210>  12398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12398
uggcucauca ucuucauugc                                                   20


<210>  12399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12399
aucagaucuu cuauuacacc                                                   20


<210>  12400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12400
ccaucagauc uucuauuaca                                                   20


<210>  12401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12401
uaaagaaaaa uaaaaaaaaa                                                   20


<210>  12402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12402
gacuguccag ggaggagagg                                                   20


<210>  12403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12403
cuggacaguc agaguuuucu                                                   20


<210>  12404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12404
ucccuggaca gucagaguuu                                                   20


<210>  12405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12405
ccucccugga cagucagagu                                                   20


<210>  12406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12406
uuuuucuuau aaacagacau                                                   20


<210>  12407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12407
cccuggcaaa gggugauuau                                                   20


<210>  12408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12408
ucccuccccc uggcaaaggg                                                   20


<210>  12409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12409
cucuucccuc ccccuggcaa                                                   20


<210>  12410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12410
uuuuuaccug aacugaaacu                                                   20


<210>  12411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12411
ucauuccagg ggccugggaa                                                   20


<210>  12412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12412
aacacgauga agcaacgucc                                                   20


<210>  12413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12413
ucaaaaaaug cuuccagacg                                                   20


<210>  12414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12414
cuuucuacuc aaaguauaau                                                   20


<210>  12415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12415
uucuacucaa aguauaauuc                                                   20


<210>  12416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12416
aaguauaauu ccuugaacau                                                   20


<210>  12417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12417
cuaaacuuau agaauauuga                                                   20


<210>  12418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12418
aaacuuauag aauauugaau                                                   20


<210>  12419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12419
uauuuagagu caguucaaua                                                   20


<210>  12420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12420
aaauaagaga acuuccuauu                                                   20


<210>  12421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12421
aaagcaccug guauugaacu                                                   20


<210>  12422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12422
acaugugaca caguuuucug                                                   20


<210>  12423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12423
gcaacaugga ccuuuucuug                                                   20


<210>  12424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12424
gacccacucc gcaacaugga                                                   20


<210>  12425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12425
ccuggacucu gacccacucc                                                   20


<210>  12426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12426
cauacaaguc ugacugggga                                                   20


<210>  12427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12427
uaccuauugc caguucccca                                                   20


<210>  12428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12428
cugaccucuu accuauugcc                                                   20


<210>  12429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12429
cgcuuugggg caccucccug                                                   20


<210>  12430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12430
ccagcaguug aaaauucucc                                                   20


<210>  12431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12431
uuccucccca gcaguugaaa                                                   20


<210>  12432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12432
cauuuuccau guagcaaagc                                                   20


<210>  12433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12433
ucucacauuu uccauguagc                                                   20


<210>  12434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12434
gaguggaaau acuggccuga                                                   20


<210>  12435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12435
gagugcucuu cucacauuuu                                                   20


<210>  12436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12436
ggccaguauu uccacucuga                                                   20


<210>  12437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12437
aggcucaggc caguauuucc                                                   20


<210>  12438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12438
ugcucuaggc ucaggccagu                                                   20


<210>  12439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12439
agcaggccug gugaguuugg                                                   20


<210>  12440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12440
ccaggccugc uugagccucu                                                   20


<210>  12441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12441
acugugcuuc agcuacauca                                                   20


<210>  12442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12442
cuuugcagac aucuuccugu                                                   20


<210>  12443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12443
ccagacuugc cccaaccucc                                                   20


<210>  12444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12444
aggcaaagga aaaccauuag                                                   20


<210>  12445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12445
aaugguuuuc cuuugccuag                                                   20


<210>  12446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12446
aaaaccucua augguuuucc                                                   20


<210>  12447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12447
uuggaaaaau ugaaagcugg                                                   20


<210>  12448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12448
agcuuucaau uuuuccaaag                                                   20


<210>  12449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12449
aaauugccuc cagcuuucaa                                                   20


<210>  12450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12450
gccauucaac uuauuuuucu                                                   20


<210>  12451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12451
gcagacuggc aaauagaaaa                                                   20


<210>  12452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12452
ccaggaauga aauauucacc                                                   20


<210>  12453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12453
uucauaauug acgaugaugc                                                   20


<210>  12454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12454
uagaaagucu acucuuugaa                                                   20


<210>  12455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12455
uugaaugcuu cuauaauugg                                                   20


<210>  12456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12456
aaccccuuga cccaauuugc                                                   20


<210>  12457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12457
aauuuaugaa ggaaaucccu                                                   20


<210>  12458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12458
ucuccaccuc uaggaagaaa                                                   20


<210>  12459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12459
accucuagga agaaacacuu                                                   20


<210>  12460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12460
aggaagaaac acuugaagau                                                   20


<210>  12461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12461
auuuggguuc auuuuuuaaa                                                   20


<210>  12462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12462
auaucucuau uuggguucau                                                   20


<210>  12463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12463
uucauuugau uuuagguaau                                                   20


<210>  12464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12464
ccauccaacc gguuaacaga                                                   20


<210>  12465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12465
agcccuguaa aaacagaauc                                                   20


<210>  12466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12466
ccagcccugu aaaaacagaa                                                   20


<210>  12467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12467
ugucuuacuu uucuaguucu                                                   20


<210>  12468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12468
gcuaauauac cgaaggcccu                                                   20


<210>  12469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12469
uguaugacaa gauucagccu                                                   20


<210>  12470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12470
uccuguauga caagauucag                                                   20


<210>  12471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12471
guccagggca uggagcauga                                                   20


<210>  12472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12472
augcccugga cugagaaaca                                                   20


<210>  12473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12473
aaacacacac acauuccagg                                                   20


<210>  12474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12474
caccccucua aacacacaca                                                   20


<210>  12475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12475
acccucccac cccucuaaac                                                   20


<210>  12476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12476
ccacccuccc accccucuaa                                                   20


<210>  12477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12477
ugagaaugaa ggcugcuuug                                                   20


<210>  12478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12478
agagaacugg guuccgaucu                                                   20


<210>  12479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12479
aaaauuucuc uuacaggauu                                                   20


<210>  12480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12480
uacaggauuu aguuaaaaua                                                   20


<210>  12481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12481
cauaaauaua uauuuuaacu                                                   20


<210>  12482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12482
uaauaagaau gagcaaaaug                                                   20


<210>  12483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12483
uucuuauuaa gagauuuuau                                                   20


<210>  12484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12484
uuggcauuug gccuugaccc                                                   20


<210>  12485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12485
aaacaucagc cuucacuuua                                                   20


<210>  12486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12486
agggaagaga uauucauaaa                                                   20


<210>  12487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12487
gaaauauagc uauuuaugaa                                                   20


<210>  12488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12488
gaaaauuagu uuuggucuuu                                                   20


<210>  12489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12489
uuuaaacaac uucuaguuca                                                   20


<210>  12490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12490
aggguauaau cacuuuuuag                                                   20


<210>  12491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12491
aucuaagaaa caaguuuaau                                                   20


<210>  12492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12492
aauugccaua uacuguaaac                                                   20


<210>  12493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12493
guaagcauuc auuagcuuag                                                   20


<210>  12494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12494
cguuagcuug caauaaaaau                                                   20


<210>  12495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12495
aagugcuuua caggcaucaa                                                   20


<210>  12496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12496
uuuacuuauu gcaaggggaa                                                   20


<210>  12497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12497
uagccaauua aaaauuucaa                                                   20


<210>  12498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12498
auuuauucau gcaaaaggaa                                                   20


<210>  12499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12499
uuggugucua aucuguaaua                                                   20


<210>  12500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12500
agcacagauc cacuauguuc                                                   20


<210>  12501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12501
cuuaccucca gcacagaucc                                                   20


<210>  12502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12502
ggaaccccua ggguaucagc                                                   20


<210>  12503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12503
aaggcccugg auucuauucc                                                   20


<210>  12504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12504
gguuggaaua gaauccaggg                                                   20


<210>  12505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12505
aggacauuug aauuuugcuu                                                   20


<210>  12506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12506
ggcuuuaggg cagcgguugg                                                   20


<210>  12507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12507
acagaagaaa ucacauaaac                                                   20


<210>  12508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12508
gaaauaaggc cacuuccuau                                                   20


<210>  12509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12509
ugauaugcug uucccugaaa                                                   20


<210>  12510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12510
ggaugguaaa gucaaaauag                                                   20


<210>  12511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12511
ugaggaacau cugaaauguu                                                   20


<210>  12512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12512
ugagaacucu ggaugguaaa                                                   20


<210>  12513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12513
agaagccugc aacauuucag                                                   20


<210>  12514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12514
caaagugcug ggauuacagg                                                   20


<210>  12515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12515
gccucccaaa gugcugggau                                                   20


<210>  12516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12516
cucggccucc caaagugcug                                                   20


<210>  12517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12517
ugugacccac cucccucggc                                                   20


<210>  12518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12518
ugaccucaug ugacccaccu                                                   20


<210>  12519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12519
cgcuacuaaa aaugcaaaaa                                                   20


<210>  12520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12520
cuacuaaaaa ugcaaaaauu                                                   20


<210>  12521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12521
uuucacauug auuuuggcuu                                                   20


<210>  12522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12522
uuaauauuuu cuguuguuuu                                                   20


<210>  12523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12523
aaaccaguca uaaaaauuug                                                   20


<210>  12524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12524
gaccaaauuu uuaugacugg                                                   20


<210>  12525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12525
caaacaccaa aauaaccuga                                                   20


<210>  12526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12526
aacaccaaaa uaaccugaau                                                   20


<210>  12527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12527
ugaaacauaa acucuccaag                                                   20


<210>  12528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12528
ccaagaggau uucuguuuua                                                   20


<210>  12529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12529
aagaggauuu cuguuuuaca                                                   20


<210>  12530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12530
uggagaguuu auguuucaug                                                   20


<210>  12531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12531
uacucuuauu uaugcgaaga                                                   20


<210>  12532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12532
uauuuaugcg aagaauggau                                                   20


<210>  12533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12533
agggcuucug uucaaccauu                                                   20


<210>  12534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12534
aaaguugcuu uuugaugcca                                                   20


<210>  12535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12535
cucgaaaguu gcuuuuugau                                                   20


<210>  12536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12536
cacucgaaag uugcuuuuug                                                   20


<210>  12537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12537
ccucucacuc gaaaguugcu                                                   20


<210>  12538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12538
auauuuugau uauuuaauuu                                                   20


<210>  12539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12539
augucuauuu aaaugugcug                                                   20


<210>  12540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12540
gcccgaguca gucaguuacc                                                   20


<210>  12541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12541
ggcagaggga uaccacgcaa                                                   20


<210>  12542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12542
uggcaaaagc aaagacacug                                                   20


<210>  12543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12543
uaaaguuuaa gguguuggcu                                                   20


<210>  12544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12544
uggguuaugc ugcaaucgcc                                                   20


<210>  12545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12545
ccacuuuauu cucauggguu                                                   20


<210>  12546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12546
ggaggaaaaa cucaaucuca                                                   20


<210>  12547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12547
ggagucuccc cacuuuauuc                                                   20


<210>  12548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12548
aucucacacc uacuaaauuu                                                   20


<210>  12549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12549
caccuacuaa auuuucauau                                                   20


<210>  12550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12550
acacugaaau guuucaacgu                                                   20


<210>  12551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12551
ggaagaccca uacaauaauu                                                   20


<210>  12552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12552
guuuuuucaa uuauuguaug                                                   20


<210>  12553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12553
guaauugacu ugguaauccu                                                   20


<210>  12554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12554
caguaauuga cuugguaauc                                                   20


<210>  12555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12555
cucucaguaa uugacuuggu                                                   20


<210>  12556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12556
acuauuuccu uuuuauuuuu                                                   20


<210>  12557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12557
cagggaguua aaauucucuc                                                   20


<210>  12558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12558
cugggagcug uuugaauuga                                                   20


<210>  12559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12559
cuauauggug aacagugugu                                                   20


<210>  12560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12560
auauggugaa cagugugugc                                                   20


<210>  12561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12561
ugcaauccag gucuuaaacc                                                   20


<210>  12562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12562
ggcuauuguu uaacauucua                                                   20


<210>  12563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12563
cauauguaga auguuaaaca                                                   20


<210>  12564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12564
uucuuucauu cuguaucuca                                                   20


<210>  12565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12565
aggcaaucuc aagcuuuagu                                                   20


<210>  12566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12566
agcuuuagua guucagacag                                                   20


<210>  12567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12567
aacugacaau uaauauuaau                                                   20


<210>  12568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12568
cgugugauaa ugccacauug                                                   20


<210>  12569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12569
gggagaaaua gaaaaccuug                                                   20


<210>  12570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12570
cugagccaag uaaucccuuu                                                   20


<210>  12571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12571
uuccucuuuu guuuggacgc                                                   20


<210>  12572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12572
uuuguuugga cgcagcucua                                                   20


<210>  12573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12573
aggugugcuu aacuauuuuc                                                   20


<210>  12574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12574
aggggaaaag aaacaaaaac                                                   20


<210>  12575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12575
uuuuguuuuu guuucuuuuc                                                   20


<210>  12576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12576
agaaugccuc gucaccuguc                                                   20


<210>  12577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12577
gaugaugagu gagaaguugg                                                   20


<210>  12578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12578
ucaucagagc aaaaguugaa                                                   20


<210>  12579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12579
cucaucauca gagcaaaagu                                                   20


<210>  12580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12580
ugaaaaaaca cuucuaauuc                                                   20


<210>  12581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12581
uccucuuugc uuguccuuua                                                   20


<210>  12582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12582
uugcuugucc uuuagcacaa                                                   20


<210>  12583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12583
cccuugugcu aaaggacaag                                                   20


<210>  12584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12584
ggcggcagcu gccugguucg                                                   20


<210>  12585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12585
gccacccggg gcgcccgccg                                                   20


<210>  12586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12586
accgccccgc gggggaggcc                                                   20


<210>  12587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12587
cccgcggggc gguggaggcg                                                   20


<210>  12588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12588
ggccgcacga uggcgcccgc                                                   20


<210>  12589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12589
gggggcgcag uguccagcuc                                                   20


<210>  12590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12590
gcgccuccgg gggcgcagug                                                   20


<210>  12591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12591
aagcuccacg gggacgcugg                                                   20


<210>  12592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12592
acggggacgc uggugucauc                                                   20


<210>  12593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12593
agguuaaauu uguuggagua                                                   20


<210>  12594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12594
gguaauugga aguagcuuaa                                                   20


<210>  12595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12595
guggcuaugc cacagaauca                                                   20


<210>  12596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12596
uuaagcaccu aaggcagccc                                                   20


<210>  12597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12597
ccugaucaua aagaagacgu                                                   20


<210>  12598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12598
ugaucauaaa gaagacguga                                                   20


<210>  12599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12599
agcuuuuucc auuuggcaug                                                   20


<210>  12600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12600
aagcaggcag gugaaccagg                                                   20


<210>  12601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12601
ccaaaucaga ugcuuugcuc                                                   20


<210>  12602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12602
ugcuccccaa aucagaugcu                                                   20


<210>  12603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12603
ccugcucccc aaaucagaug                                                   20


<210>  12604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12604
ccugcucucc ugcuccccaa                                                   20


<210>  12605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12605
ccccugcucu ccugcucccc                                                   20


<210>  12606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12606
cuccccugcu cuccugcucc                                                   20


<210>  12607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12607
cucuccccug cucuccugcu                                                   20


<210>  12608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12608
auaagcucuc ucuccccugc                                                   20


<210>  12609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12609
ugccucagcu gaggcuuauu                                                   20


<210>  12610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12610
gcugaggcuu auuggccgug                                                   20


<210>  12611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12611
gcugaggcaa gaggcaucua                                                   20


<210>  12612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12612
ugacacggcc aauaagccuc                                                   20


<210>  12613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12613
aguuccuuaa cuacccccua                                                   20


<210>  12614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12614
ccccucaaaa gagaagauug                                                   20


<210>  12615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12615
ccucaaaaga gaagauuggc                                                   20


<210>  12616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12616
aaagagaaga uuggcgccau                                                   20


<210>  12617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12617
uuugagggga gagaagggaa                                                   20


<210>  12618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12618
uugaggaaga cuuuggccuc                                                   20


<210>  12619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12619
aggagccaau ggcgccaauc                                                   20


<210>  12620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12620
augugcaugu gugugugugu                                                   20


<210>  12621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12621
cgauggggau ccaugaagcu                                                   20


<210>  12622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12622
auggggaucc augaagcuuc                                                   20


<210>  12623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12623
gccuugccuu gggcuccccu                                                   20


<210>  12624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12624
ccuugggcuc cccuugggcu                                                   20


<210>  12625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12625
ccuugggcuc cuggcucacg                                                   20


<210>  12626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12626
uggcucacgg gagacagagg                                                   20


<210>  12627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12627
cgggagacag agguugguga                                                   20


<210>  12628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12628
cgugagccag gagcccaagg                                                   20


<210>  12629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12629
gucucccgug agccaggagc                                                   20


<210>  12630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12630
ccaaccucug ucucccguga                                                   20


<210>  12631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12631
augcacuuca caauuaauuc                                                   20


<210>  12632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12632
caaugcacuu cacaauuaau                                                   20


<210>  12633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12633
gccgcgggac ugguuuucau                                                   20


<210>  12634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12634
ccgccgcggg acugguuuuc                                                   20


<210>  12635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12635
uaggauauga cuguggcagc                                                   20


<210>  12636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12636
gggguuuggg cugccacagu                                                   20


<210>  12637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12637
ccucuggggu uugggcugcc                                                   20


<210>  12638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12638
aggcugauag auuuucagag                                                   20


<210>  12639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12639
gaaaaucuau cagccuugag                                                   20


<210>  12640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12640
agucuccggc uucccuuccc                                                   20


<210>  12641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12641
ggcuucccuu cccuccaggg                                                   20


<210>  12642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12642
agggcggggg ugagcaaggc                                                   20


<210>  12643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12643
cccccgcccu ggagggaagg                                                   20


<210>  12644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12644
gccuugcuca cccccgcccu                                                   20


<210>  12645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12645
ccagcccacg acccacucug                                                   20


<210>  12646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12646
caucagcagc cuuuggaagg                                                   20


<210>  12647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12647
agaacguggg gucagccuuc                                                   20


<210>  12648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12648
caagaacgug gggucagccu                                                   20


<210>  12649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12649
cuucacuguu cucuucccug                                                   20


<210>  12650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12650
ucccugucug aaauggcagg                                                   20


<210>  12651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12651
uaggucaccu gccauuucag                                                   20


<210>  12652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12652
cucuuagguc accugccauu                                                   20


<210>  12653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12653
aaaucaauuu gcacaccgcu                                                   20


<210>  12654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12654
gggcgcggcc ccggcucgcu                                                   20


<210>  12655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12655
cugccguguc acugauccuc                                                   20


<210>  12656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12656
ccaaaucgau ucacacacca                                                   20


<210>  12657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12657
aaaucgauuc acacaccauu                                                   20


<210>  12658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12658
ucagcacacc ugccauguca                                                   20


<210>  12659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12659
gcacaccugc caugucagau                                                   20


<210>  12660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12660
aucugacaug gcaggugugc                                                   20


<210>  12661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12661
ccaucugaca uggcaggugu                                                   20


<210>  12662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12662
cuucaugcgu cccucuccau                                                   20


<210>  12663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12663
gccgcugccg ccucuccucg                                                   20


<210>  12664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12664
ccucguccca gcuccccacc                                                   20


<210>  12665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12665
ucgucccagc uccccaccac                                                   20


<210>  12666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12666
ucccagcucc ccaccacguu                                                   20


<210>  12667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12667
guguauucgc cuucuggugu                                                   20


<210>  12668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12668
augaaggaag cagugcauuu                                                   20


<210>  12669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12669
gacuccuugc cucucucuua                                                   20


<210>  12670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12670
gaauugugcu ucugucauca                                                   20


<210>  12671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12671
cugaauugug cuucugucau                                                   20


<210>  12672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12672
gacucucuga auugugcuuc                                                   20


<210>  12673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12673
cugacucucu gaauugugcu                                                   20


<210>  12674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12674
cucugacucu cugaauugug                                                   20


<210>  12675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12675
gaagagucca caaacaaagc                                                   20


<210>  12676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12676
uuauaccaau gcagcuguaa                                                   20


<210>  12677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12677
agauuagagg uguuuccuau                                                   20


<210>  12678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12678
aaucuugagg gaaaccauuu                                                   20


<210>  12679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12679
guuauaaaua ggaaacaccu                                                   20


<210>  12680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12680
cuggaagauu ucuggaugac                                                   20


<210>  12681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12681
ugagccacug aaaucaagau                                                   20


<210>  12682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12682
agagcagaca aaagcaggau                                                   20


<210>  12683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12683
gccuguggaa gaaucuugau                                                   20


<210>  12684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12684
cagcaaacuc uuugacuuac                                                   20


<210>  12685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12685
gcaaacucuu ugacuuacug                                                   20


<210>  12686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12686
uugacuuacu guccagguuc                                                   20


<210>  12687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12687
gccaacagca aauaagugag                                                   20


<210>  12688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12688
cuuauuugcu guuggcagag                                                   20


<210>  12689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12689
uuggaagcau ucucacuuau                                                   20


<210>  12690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12690
ucucauuugu aaaagggagu                                                   20


<210>  12691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12691
uuuguaaaag ggagugucag                                                   20


<210>  12692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12692
cuuuuacaaa ugagaagaga                                                   20


<210>  12693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12693
uaugcauagc uaagaauagc                                                   20


<210>  12694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12694
cagucuccua ugcauagcua                                                   20


<210>  12695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12695
cuguggguug uggguagaug                                                   20


<210>  12696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12696
guggguugug gguagauggu                                                   20


<210>  12697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12697
ugcaaauguu uaaagaugaa                                                   20


<210>  12698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12698
cagauauuau ugcugaucug                                                   20


<210>  12699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12699
uuucacuggu gugaagcagc                                                   20


<210>  12700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12700
ugcuuggaau gcccuuuccu                                                   20


<210>  12701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12701
ggaccucacu uggcucccuc                                                   20


<210>  12702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12702
cuuggcuccc uccucacugu                                                   20


<210>  12703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12703
cuccucacug uuuagaccuc                                                   20


<210>  12704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12704
ucacuguuua gaccucaacu                                                   20


<210>  12705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12705
cuguuuagac cucaacuuaa                                                   20


<210>  12706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12706
acuuaaaugu caccuccaca                                                   20


<210>  12707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12707
agaaguaaga aaguguucuu                                                   20


<210>  12708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12708
gcagugaagu caucaggucc                                                   20


<210>  12709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12709
aacucuucag aaaaauugaa                                                   20


<210>  12710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12710
ucagaaaaau ugaagagaag                                                   20


<210>  12711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12711
ggccaagacu uccaguauua                                                   20


<210>  12712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12712
ugccuaauug cucuggccaa                                                   20


<210>  12713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12713
accaaaaaau uguuagaacu                                                   20


<210>  12714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12714
guagacacuu cucaaaauaa                                                   20


<210>  12715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12715
aaauaauaua uacaaauggc                                                   20


<210>  12716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12716
ucaucauaau cagagaaaug                                                   20


<210>  12717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12717
gauuaugaug augagugaua                                                   20


<210>  12718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12718
uuaugguuuu gauuugcauu                                                   20


<210>  12719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12719
auauccuagc cagcauccau                                                   20


<210>  12720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12720
aaaggguggc cuagccauca                                                   20


<210>  12721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12721
ccuguaaugc cacuaguguu                                                   20


<210>  12722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12722
guugccuuuu uauaaaccua                                                   20


<210>  12723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12723
acccuccguu gccuuuuuau                                                   20


<210>  12724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12724
ccacccuccg uugccuuuuu                                                   20


<210>  12725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12725
cucuccaccc uccguugccu                                                   20


<210>  12726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12726
aggcaaaagc accauuaugg                                                   20


<210>  12727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12727
auaauggugc uuuugccuug                                                   20


<210>  12728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12728
ccauaauggu gcuuuugccu                                                   20


<210>  12729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12729
uagccuuguc ugaaauguug                                                   20


<210>  12730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12730
aaguucuuca aaaugcaauu                                                   20


<210>  12731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12731
cccuucaccc ccgccccaac                                                   20


<210>  12732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12732
uacucuauuu ugggaacccu                                                   20


<210>  12733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12733
auuuugggaa cccucuuuuc                                                   20


<210>  12734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12734
uuucguaaag aaccaggucu                                                   20


<210>  12735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12735
gagacacagc uguggaucug                                                   20


<210>  12736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12736
gagaccuggu ucuuuacgaa                                                   20


<210>  12737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12737
ugccuuugac aucugagcaa                                                   20


<210>  12738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12738
gaugucaaag gcaugagggg                                                   20


<210>  12739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12739
ugcucagaug ucaaaggcau                                                   20


<210>  12740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12740
aauaucucuu gcucagaugu                                                   20


<210>  12741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12741
accacaauga agauccacuu                                                   20


<210>  12742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12742
gcccaccugu ccacagagac                                                   20


<210>  12743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12743
ccugucacaa aaagauaugg                                                   20


<210>  12744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12744
augacucccc ugucacaaaa                                                   20


<210>  12745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12745
ucacuugcuc ugaaauuuau                                                   20


<210>  12746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12746
gaaauuuauc ugaagucaaa                                                   20


<210>  12747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12747
uuuugacuuc agauaaauuu                                                   20


<210>  12748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12748
aagaaggucu augugaccua                                                   20


<210>  12749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12749
accaaaauga cuaugugcaa                                                   20


<210>  12750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12750
augcaugauu acuugcacau                                                   20


<210>  12751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12751
uuguccuuuu cuuucuccau                                                   20


<210>  12752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12752
uguguuucug uaaccaagcc                                                   20


<210>  12753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12753
agaaccucag aaugugaccu                                                   20


<210>  12754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12754
gaaugugacc uuauuuggaa                                                   20


<210>  12755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12755
gcuaguuucu ggagaugugc                                                   20


<210>  12756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12756
cugcuaguuu cuggagaugu                                                   20


<210>  12757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12757
ucaaacucuc ugcuaguuuc                                                   20


<210>  12758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12758
gaaggaacca gcccugcuga                                                   20


<210>  12759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12759
uacaacaaag aauuaucaga                                                   20


<210>  12760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12760
aaaugugaau aguuugaaga                                                   20


<210>  12761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12761
gucuucaaac uauucacauu                                                   20


<210>  12762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12762
gagggcguaa gcaauucaca                                                   20


<210>  12763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12763
gagcuuccau uucuguaccu                                                   20


<210>  12764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12764
aagaaaauua gggcaaaacu                                                   20


<210>  12765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12765
aguuuugccc uaauuuucuu                                                   20


<210>  12766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12766
aggaucaugu auaggagcau                                                   20


<210>  12767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12767
uauacaugau ccuugagcac                                                   20


<210>  12768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12768
ggaaggcuuc caguuuuccu                                                   20


<210>  12769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12769
uaugcauugc ggauaugccu                                                   20


<210>  12770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12770
cuggguuuuu uuuuguuguu                                                   20


<210>  12771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12771
cagcacccug ugcucagaag                                                   20


<210>  12772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12772
gaagggaacc ccgggcuagg                                                   20


<210>  12773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12773
guggucacca ucuucaaaau                                                   20


<210>  12774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12774
ugaccuauug uaguuucuuu                                                   20


<210>  12775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12775
cuugaccuau uguaguuucu                                                   20


<210>  12776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12776
cucuugaccu auuguaguuu                                                   20


<210>  12777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12777
cucucucuug accuauugua                                                   20


<210>  12778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12778
uuuuaugcca guuagcagga                                                   20


<210>  12779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12779
guucuuucag cuccuuuuau                                                   20


<210>  12780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12780
aggaaacuuu cugcuucuca                                                   20


<210>  12781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12781
cagacacagg gauaaaauga                                                   20


<210>  12782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12782
aagaucugaa aucaggaaau                                                   20


<210>  12783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12783
uauucucuaa gaucugaaau                                                   20


<210>  12784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12784
gcccuccuau ucucuaagau                                                   20


<210>  12785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12785
cuaaggcagg uuggggcccu                                                   20


<210>  12786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12786
gagagcaucu cuucugagca                                                   20


<210>  12787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12787
gagaagccuu cgcugcccuc                                                   20


<210>  12788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12788
cggagaagcc uucgcugccc                                                   20


<210>  12789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12789
ucugagcaga guccugagcg                                                   20


<210>  12790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12790
gaagagaugc ucucggagaa                                                   20


<210>  12791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12791
gcucagaaga gaugcucucg                                                   20


<210>  12792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12792
ggacucugcu cagaagagau                                                   20


<210>  12793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12793
cucaggacuc ugcucagaag                                                   20


<210>  12794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12794
gaaugguccu cgcucaggac                                                   20


<210>  12795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12795
guuuucuucc ucugaauggu                                                   20


<210>  12796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12796
uuggaauaac agcuccguuu                                                   20


<210>  12797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12797
gccuccuugg aauaacagcu                                                   20


<210>  12798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12798
cugccuccuu ggaauaacag                                                   20


<210>  12799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12799
agcuacuugg aaugauuugc                                                   20


<210>  12800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12800
ucccuguacu ccagcuacuu                                                   20


<210>  12801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12801
ucuucccugu acuccagcua                                                   20


<210>  12802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12802
gagaaggagg cccacaucac                                                   20


<210>  12803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12803
gagugcuccu cuucccugua                                                   20


<210>  12804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12804
uucucugagu gcuccucuuc                                                   20


<210>  12805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12805
uugguucagg uccuuguugc                                                   20


<210>  12806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12806
auuccaacug ccaccuccuu                                                   20


<210>  12807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12807
ccauuccaac ugccaccucc                                                   20


<210>  12808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12808
aggucaccca acuggggguc                                                   20


<210>  12809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12809
caaggucacc caacuggggg                                                   20


<210>  12810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12810
uggaauaaau ucaugggaua                                                   20


<210>  12811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12811
augaucaugu ucugcuauug                                                   20


<210>  12812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12812
ucuugaaagu gggauagacc                                                   20


<210>  12813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12813
ugaaaguggg auagaccuag                                                   20


<210>  12814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12814
aaugaauaga auauggcaaa                                                   20


<210>  12815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12815
uaaccuuugc cauauucuau                                                   20


<210>  12816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12816
gaagaaacgu cucauaaccu                                                   20


<210>  12817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12817
aagcuacagc auuuaucauc                                                   20


<210>  12818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12818
ucaguacaau aagcaagaua                                                   20


<210>  12819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12819
uauuccuugu gacuauaacc                                                   20


<210>  12820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12820
aaauguacuu gaaauuuuuc                                                   20


<210>  12821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12821
agaaguucuc caaauguacu                                                   20


<210>  12822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12822
acaaaaacaa auagauaaau                                                   20


<210>  12823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12823
acugaaaaag aaagacaaaa                                                   20


<210>  12824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12824
ugagcucagg ugaccugccc                                                   20


<210>  12825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12825
ggaguuccgg accagugugg                                                   20


<210>  12826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12826
ggugaccugc ccaccucaga                                                   20


<210>  12827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12827
gacucccaaa gugcugggau                                                   20


<210>  12828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12828
caaagugcug ggauuacagg                                                   20


<210>  12829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12829
ugccuguaau cccagcacuu                                                   20


<210>  12830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12830
aggccaggca ugcuggcuca                                                   20


<210>  12831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12831
uuuauaaaca auaguugucu                                                   20


<210>  12832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12832
acuuacaaca cuuugacaua                                                   20


<210>  12833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12833
uuguaugacu gucucuccau                                                   20


<210>  12834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12834
ccauuaagcu agaagaucuu                                                   20


<210>  12835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12835
auuaagcuag aagaucuugg                                                   20


<210>  12836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12836
ucuauucaac uuugcagccc                                                   20


<210>  12837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12837
auucaacuuu gcagcccuaa                                                   20


<210>  12838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12838
uucaacaaac acuuggucac                                                   20


<210>  12839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12839
aaaucucuau caaacuuuug                                                   20


<210>  12840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12840
aucaaacuuu uguuugauua                                                   20


<210>  12841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12841
caagaggaau uuggauauua                                                   20


<210>  12842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12842
ugggaguaga acuagauuaa                                                   20


<210>  12843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12843
auuaauaucc aaauuccucu                                                   20


<210>  12844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12844
gcuaguuuug guuuaccaga                                                   20


<210>  12845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12845
agcgcuauuu uuugacauuu                                                   20


<210>  12846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12846
ccuacuuuua acaaauguca                                                   20


<210>  12847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12847
uguuuuaaac aauuuauacc                                                   20


<210>  12848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12848
cgucucaugu uuuaaacaau                                                   20


<210>  12849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12849
cacuuucaaa uucuuucuga                                                   20


<210>  12850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12850
uaacuucuac agaaauucca                                                   20


<210>  12851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12851
cugcuuugcc guuuccuacg                                                   20


<210>  12852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12852
uuuagacccg gggcagagcu                                                   20


<210>  12853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12853
gccccggguc uaaaugagaa                                                   20


<210>  12854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12854
guuccgcuuu ucaaugaaua                                                   20


<210>  12855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12855
agucuggcug gggacacuau                                                   20


<210>  12856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12856
gcucagguaa cuauuaucuu                                                   20


<210>  12857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12857
gguaacuauu aucuuauccu                                                   20


<210>  12858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12858
aaagcauugg gaaaauuuuc                                                   20


<210>  12859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12859
auaccugugg aaagcggugg                                                   20


<210>  12860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12860
uuucauuuag cuuacauuug                                                   20


<210>  12861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12861
cuccuuucuu cucaaacaag                                                   20


<210>  12862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12862
ccuuucuucu caaacaaggg                                                   20


<210>  12863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12863
uuucuucuca aacaaggggc                                                   20


<210>  12864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12864
aacaaggggc ccacuucggu                                                   20


<210>  12865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12865
gcuaaaucgu uucuaacgcu                                                   20


<210>  12866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12866
cucauugucc cacccugccu                                                   20


<210>  12867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12867
uugucccacc cugccucacc                                                   20


<210>  12868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12868
ccucuggcuc caauuagagc                                                   20


<210>  12869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12869
ggcuccaauu agagcaauau                                                   20


<210>  12870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12870
aauuagagca auauuuauuu                                                   20


<210>  12871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12871
aauuggagcc agaggugagg                                                   20


<210>  12872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12872
guagccucua cucuucggaa                                                   20


<210>  12873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12873
acucuucgga aaugaggcaa                                                   20


<210>  12874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12874
ucggaaauga ggcaacgcag                                                   20


<210>  12875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12875
uuuccgaaga guagaggcua                                                   20


<210>  12876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12876
uguuaaaagc ccuuuauuau                                                   20


<210>  12877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12877
gacaagaucc agcucgacaa                                                   20


<210>  12878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12878
acaagauugu guuccuggag                                                   20


<210>  12879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12879
aggaacacaa ucuugucgag                                                   20


<210>  12880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12880
uuuaucuguc aucucacuuu                                                   20


<210>  12881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12881
cuuucuaggu cacaucauuu                                                   20


<210>  12882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12882
auugcuuuaa aauauauaua                                                   20


<210>  12883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12883
uccauugcuu uaaaauauau                                                   20


<210>  12884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12884
gcauuccacu ccuccauugc                                                   20


<210>  12885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12885
cuccgcauuc cacuccucca                                                   20


<210>  12886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12886
uggugcugga auguagaaaa                                                   20


<210>  12887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12887
ucuaauuuca augaagggca                                                   20


<210>  12888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12888
ggaaaauggc agcaugcccu                                                   20


<210>  12889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12889
uccuucucug gaaaauggca                                                   20


<210>  12890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12890
augaacuaaa auaaacccca                                                   20


<210>  12891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12891
gggauuuggg gccucaagaa                                                   20


<210>  12892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12892
agaacuccgg gaggacccua                                                   20


<210>  12893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12893
gggaggaccc uacaggcccc                                                   20


<210>  12894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12894
cggaguucuu gaggccccaa                                                   20


<210>  12895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12895
gagcccaagc ucuuagcuug                                                   20


<210>  12896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12896
gagccagaca guucaaguuc                                                   20


<210>  12897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12897
uagcuugacu ugguucaugu                                                   20


<210>  12898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12898
aauauaucuu uuuuggggga                                                   20


<210>  12899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12899
gaauguuacc uuauauggau                                                   20


<210>  12900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12900
uuguaaagca aagucacucu                                                   20


<210>  12901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12901
aggcucaaaa uucauuuagc                                                   20


<210>  12902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12902
aaauucauuu agcaaaaagu                                                   20


<210>  12903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12903
aauccuccuc cugcccacca                                                   20


<210>  12904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12904
uccugcccac cagacuuggg                                                   20


<210>  12905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12905
ugcccaccag acuugggccu                                                   20


<210>  12906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12906
uuugaagacc caggcccaag                                                   20


<210>  12907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12907
aaaaagcuau auauaaguca                                                   20


<210>  12908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12908
auaaauuuau ugacuuauau                                                   20


<210>  12909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12909
gggaagcuuc cugauccccc                                                   20


<210>  12910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12910
caucuauugc acuuuagguc                                                   20


<210>  12911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12911
caccuguaau ccuagcacuu                                                   20


<210>  12912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12912
auuaaggcua gguguggugg                                                   20


<210>  12913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12913
gauuaaacag uguuggccag                                                   20


<210>  12914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12914
cacaguucug gagaccagaa                                                   20


<210>  12915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12915
caguucugga gaccagaagg                                                   20


<210>  12916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12916
agaacuguga gagacuaaau                                                   20


<210>  12917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12917
aaaggagagu cuguucaugc                                                   20


<210>  12918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12918
aguccccaaa caauaauaaa                                                   20


<210>  12919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12919
ugccgaauca aaguuuuauu                                                   20


<210>  12920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12920
accagucuag aaaaugaaag                                                   20


<210>  12921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12921
acugaaagua guaaaauaag                                                   20


<210>  12922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12922
cuugugaaua ucacuauugu                                                   20


<210>  12923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12923
uuccuuucuc ccuugugaau                                                   20


<210>  12924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12924
uuuauuauau uuugggguuu                                                   20


<210>  12925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12925
uauuccuauc cuuugauuca                                                   20


<210>  12926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12926
cauuagguca aaaaaaaaau                                                   20


<210>  12927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12927
ugcccuacaa gauauuuuuu                                                   20


<210>  12928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12928
uaacuccugc ccuacaagau                                                   20


<210>  12929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12929
gaguuucaug gggaauagcc                                                   20


<210>  12930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12930
gagcaacucu uaacuccugc                                                   20


<210>  12931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12931
cacugggggc aaauaaaaga                                                   20


<210>  12932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12932
cugggggcaa auaaaagaca                                                   20


<210>  12933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12933
ugucuuuuau uugcccccag                                                   20


<210>  12934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12934
uaaaucuccu gucuuuuauu                                                   20


<210>  12935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12935
gggauaauuu gucuccuaaa                                                   20


<210>  12936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12936
guucuaggaa gcuuucucug                                                   20


<210>  12937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12937
gaacauuuca gccacuuguu                                                   20


<210>  12938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12938
gugauaaauc acauuuauuu                                                   20


<210>  12939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12939
agauggacua aaauacaaaa                                                   20


<210>  12940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12940
caagauggac uaaaauacaa                                                   20


<210>  12941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12941
aauugacuuu acaauauugg                                                   20


<210>  12942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12942
acauauuugc uaaagaaaga                                                   20


<210>  12943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12943
uucuuuagca aauauguuga                                                   20


<210>  12944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12944
ucauauaccu gauuuucuca                                                   20


<210>  12945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12945
uauaccugau uuucucacca                                                   20


<210>  12946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12946
ccauucuguu acagaauaug                                                   20


<210>  12947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12947
uauucuguaa cagaauggug                                                   20


<210>  12948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12948
uuuguggugg ugcuugucuc                                                   20


<210>  12949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12949
uauuggaaac cuuuaucucu                                                   20


<210>  12950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12950
uugguaugga aauuuggggu                                                   20


<210>  12951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12951
aagaagcaua aaccccaaau                                                   20


<210>  12952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12952
ugaauucuug gcugcuaaac                                                   20


<210>  12953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12953
ccugcccaag ugugggagaa                                                   20


<210>  12954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12954
cacacuuggg caggugagau                                                   20


<210>  12955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12955
uguuuucucc cacacuuggg                                                   20


<210>  12956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12956
aaauagaaag auuuuucugg                                                   20


<210>  12957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12957
aacaucugcu ucuuggaucu                                                   20


<210>  12958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12958
gggaggcuca gaaacuggga                                                   20


<210>  12959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12959
cagagaucca agaagcagau                                                   20


<210>  12960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12960
gaaacuggga auccccuaag                                                   20


<210>  12961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12961
cuucauccau aaaggugcuu                                                   20


<210>  12962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12962
ggcuccccca aagagcggca                                                   20


<210>  12963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12963
cccaaagagc ggcaggcagg                                                   20


<210>  12964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12964
uugggggagc cagagcccuc                                                   20


<210>  12965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12965
ugccugccgc ucuuuggggg                                                   20


<210>  12966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12966
ugcugcaucc cugaaguggc                                                   20


<210>  12967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12967
guuccuuuuc guacacaucu                                                   20


<210>  12968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12968
aguugggcuu uugguccaug                                                   20


<210>  12969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12969
gaguaacaau gaccuuguga                                                   20


<210>  12970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12970
gagcuguuuu aaaaaauuau                                                   20


<210>  12971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12971
uaaaaugacg gcuucccauu                                                   20


<210>  12972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12972
guuaauucgu augcugcugu                                                   20


<210>  12973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12973
gauugaacag cagcauacga                                                   20


<210>  12974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12974
uggcuuuuag uuaaaaagcu                                                   20


<210>  12975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12975
cugugagaca gugggcaagu                                                   20


<210>  12976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12976
cagcgaggca gaagccgggc                                                   20


<210>  12977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12977
gugccuucau cucuaaaaug                                                   20


<210>  12978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12978
aaaaugggga uagcggcccc                                                   20


<210>  12979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12979
cugaugucua aagaaggcau                                                   20


<210>  12980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12980
gaaaagguac ccuaaagcca                                                   20


<210>  12981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12981
ggacuuaaaa cacaaacaga                                                   20


<210>  12982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12982
gucuucaaaa ucuguuugug                                                   20


<210>  12983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12983
aguuucucug ucuucaaaau                                                   20


<210>  12984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12984
caaauuucca uuuaaaucuc                                                   20


<210>  12985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12985
aauuuccauu uaaaucucca                                                   20


<210>  12986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12986
aaccugaucu ucucuaccaa                                                   20


<210>  12987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12987
accaaguucc agagcaacac                                                   20


<210>  12988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12988
ggaacuuggu agagaagauc                                                   20


<210>  12989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12989
auuuaugcua aacaacgaua                                                   20


<210>  12990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12990
uacccuaauu uucuguucau                                                   20


<210>  12991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12991
acuucugacu ggcuccaacu                                                   20


<210>  12992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12992
auuuccaguc cacauccaau                                                   20


<210>  12993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12993
aaucucuauu uccaguccac                                                   20


<210>  12994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12994
caaaucucua uuuccagucc                                                   20


<210>  12995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12995
ucugguuucu uccuacuucu                                                   20


<210>  12996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12996
agaagccaaa gcaagagagu                                                   20


<210>  12997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12997
ugcuuuggcu ucuagagaau                                                   20


<210>  12998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12998
cuugcuuugg cuucuagaga                                                   20


<210>  12999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  12999
ccuuggauuu uugacacuga                                                   20


<210>  13000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13000
cauucccucc ccuuggauuu                                                   20


<210>  13001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13001
uuaagcuccc auucccuccc                                                   20


<210>  13002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13002
acaccacuag ucauuagaaa                                                   20


<210>  13003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13003
uugugguuuu gauuugcauc                                                   20


<210>  13004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13004
cacccauuag cauggcuacu                                                   20


<210>  13005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13005
uuuuuccuuc cucuccagcc                                                   20


<210>  13006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13006
guagccauua aauaauaacu                                                   20


<210>  13007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13007
uuucauuuug caaaguugaa                                                   20


<210>  13008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13008
agaaaacucu uuucauuuug                                                   20


<210>  13009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13009
cauuguugug caaccauucc                                                   20


<210>  13010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13010
caaagugcug ggauuacagg                                                   20


<210>  13011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13011
ugugauccac cugccuaggc                                                   20


<210>  13012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13012
gugaauauuu uaaaauguga                                                   20


<210>  13013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13013
uuguucaguu uaaaugggug                                                   20


<210>  13014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13014
auaaauccau uucaaagaaa                                                   20


<210>  13015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13015
gggauaguca aguaaaagaa                                                   20


<210>  13016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13016
uuguaacugu cauaacaaau                                                   20


<210>  13017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13017
acugaaaccg cugcuaucac                                                   20


<210>  13018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13018
aucuucaacu uugccaagga                                                   20


<210>  13019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13019
caaucuucaa cuuugccaag                                                   20


<210>  13020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13020
cucucaaucu ucaacuuugc                                                   20


<210>  13021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13021
gcuuuccaca gauuuccccu                                                   20


<210>  13022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13022
auguagcaaa uauuuauugu                                                   20


<210>  13023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13023
uccuaaaucc cauguuauua                                                   20


<210>  13024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13024
cuuccuaaau cccauguuau                                                   20


<210>  13025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13025
uugaaguccu acuuagacau                                                   20


<210>  13026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13026
uuagucaaug uggcaauaau                                                   20


<210>  13027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13027
ucaauuauug ccacauugac                                                   20


<210>  13028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13028
ugagcuauau uucuggcaaa                                                   20


<210>  13029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13029
agagcucauc aauuauugcc                                                   20


<210>  13030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13030
cucagugacu uacccagaca                                                   20


<210>  13031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13031
gugacuuacc cagacaacua                                                   20


<210>  13032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13032
auucauggua agugcccuau                                                   20


<210>  13033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13033
auagggcacu uaccaugaau                                                   20


<210>  13034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13034
aaauguguau agcaugugau                                                   20


<210>  13035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13035
uuauccgcaa cauaaacucu                                                   20


<210>  13036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13036
guacccacua aacaguaacu                                                   20


<210>  13037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13037
uucuccccag ccccugguaa                                                   20


<210>  13038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13038
ccagccccug guaaccucua                                                   20


<210>  13039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13039
cauaaguaga aucauauaau                                                   20


<210>  13040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13040
cuggcaacac acaagguucc                                                   20


<210>  13041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13041
acauucucac caauacuugu                                                   20


<210>  13042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13042
uugugguuuu gauuugcauu                                                   20


<210>  13043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13043
ccaagcaugc agugaccaca                                                   20


<210>  13044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13044
guguguugau uguaguggug                                                   20


<210>  13045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13045
caccuauaau cccagcacuu                                                   20


<210>  13046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13046
uuucaguuuu uuuuuuuuag                                                   20


<210>  13047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13047
cuugccuuug caccacauuc                                                   20


<210>  13048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13048
gcaauuugac ccucacuugc                                                   20


<210>  13049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13049
cugcaauuug acccucacuu                                                   20


<210>  13050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13050
cucugcaauu ugacccucac                                                   20


<210>  13051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13051
uggcucuguc accccaccgc                                                   20


<210>  13052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13052
gucaccccac cgcuaucucc                                                   20


<210>  13053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13053
uuuucccacc ccucuauuuu                                                   20


<210>  13054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13054
auuuuccuau ucaucguguc                                                   20


<210>  13055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13055
augacacgau gaauaggaaa                                                   20


<210>  13056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13056
accggaacca ugcugggugg                                                   20


<210>  13057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13057
cuuuaagaaa cacauccuau                                                   20


<210>  13058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13058
uggggcugug ucuuugguca                                                   20


<210>  13059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13059
agugucucca cugaaaacag                                                   20


<210>  13060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13060
acugaaaaca gguuccucuc                                                   20


<210>  13061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13061
cugucagaug gagagaugaa                                                   20


<210>  13062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13062
gucagaugga gagaugaaau                                                   20


<210>  13063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13063
aucugacaga gaggaaccug                                                   20


<210>  13064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13064
ccaucugaca gagaggaacc                                                   20


<210>  13065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13065
ccuccugggu cuggaagcug                                                   20


<210>  13066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13066
ugggucugga agcugcacgg                                                   20


<210>  13067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13067
ugggguagau guuucagcgg                                                   20


<210>  13068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13068
ccuguacucu guugcuuuca                                                   20


<210>  13069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13069
guugcuuuca ggcuuggugc                                                   20


<210>  13070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13070
caagaaacaa agcaccaagc                                                   20


<210>  13071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13071
ugccucagcc ucccaaguag                                                   20


<210>  13072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13072
gccucccaag uagcugggac                                                   20


<210>  13073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13073
caaguagcug ggacuauagg                                                   20


<210>  13074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13074
caccugaaau cccagcaguu                                                   20


<210>  13075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13075
uaucccuuua agaauaaaug                                                   20


<210>  13076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13076
cuuaucccuu uaagaauaaa                                                   20


<210>  13077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13077
aaaguuucuc ucuuaucccu                                                   20


<210>  13078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13078
uugagaaggg agacuuaaag                                                   20


<210>  13079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13079
aagagaagcc aagguacaau                                                   20


<210>  13080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13080
cuucucaaag agaagccaag                                                   20


<210>  13081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13081
uuaguuggaa cauagaagua                                                   20


<210>  13082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13082
uucuuuguag gcagaucugg                                                   20


<210>  13083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13083
aacuugguag uagcuuuugu                                                   20


<210>  13084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13084
ugcaggauac aaaagcuacu                                                   20


<210>  13085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13085
aagugucuug ggucaacugu                                                   20


<210>  13086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13086
cugugccucu cuuuaguuuu                                                   20


<210>  13087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13087
gugccucucu uuaguuuuac                                                   20


<210>  13088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13088
uucccuugag uaauccaccu                                                   20


<210>  13089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13089
agggaaggag cuguuguaaa                                                   20


<210>  13090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13090
cacuuucucu ucacugcauc                                                   20


<210>  13091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13091
uuucuauucc aggacugggu                                                   20


<210>  13092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13092
cuuaugcuug auguuagaaa                                                   20


<210>  13093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13093
uaugcuugau guuagaaagu                                                   20


<210>  13094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13094
uaguagcacu uguacuuauu                                                   20


<210>  13095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13095
augcauauuu guugaaugaa                                                   20


<210>  13096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13096
guauguaaca caguaccuag                                                   20


<210>  13097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13097
aggacagcag ggaucuaucu                                                   20


<210>  13098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13098
cugccuuuca auuuuaaaau                                                   20


<210>  13099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13099
uuuucacugg ucaguugaag                                                   20


<210>  13100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13100
ucaagccuga ccuucaacug                                                   20


<210>  13101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13101
uucugucuuu uaaaccauga                                                   20


<210>  13102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13102
uggcuauuaa uccuuuucug                                                   20


<210>  13103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13103
ccuggcuauu aauccuuuuc                                                   20


<210>  13104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13104
gcucuccugg cuauuaaucc                                                   20


<210>  13105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13105
cugcucuccu ggcuauuaau                                                   20


<210>  13106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13106
auuccaucac ccaugagucc                                                   20


<210>  13107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13107
ugggugaugg aauugaguug                                                   20


<210>  13108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13108
guaaggacuc augggugaug                                                   20


<210>  13109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13109
guccaggugg cagcucagua                                                   20


<210>  13110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13110
ugcuaauaau auguggcugu                                                   20


<210>  13111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13111
cugcaggacc uuggcacaca                                                   20


<210>  13112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13112
agagcccaug gugggugugg                                                   20


<210>  13113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13113
ggagcaguuu ccugucaagu                                                   20


<210>  13114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13114
ggcccuaauc ccacacccac                                                   20


<210>  13115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13115
ucucaggccc uaaucccaca                                                   20


<210>  13116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13116
ccacaaagau ucacacguga                                                   20


<210>  13117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13117
uuuuuccuug cuccccacaa                                                   20


<210>  13118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13118
uauuugccuc uuuuuuccuu                                                   20


<210>  13119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13119
ggaaaguaau uaaccuuaga                                                   20


<210>  13120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13120
cuggaaagua auuaaccuua                                                   20


<210>  13121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13121
aagugugaac ucucuggaaa                                                   20


<210>  13122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13122
acaauguugc ucaaagugug                                                   20


<210>  13123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13123
aagagucuau auuguucuau                                                   20


<210>  13124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13124
uugaguauau aauagugcca                                                   20


<210>  13125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13125
ucuggugcac agagacaggg                                                   20


<210>  13126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13126
gugcaccaga agagugguua                                                   20


<210>  13127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13127
uuucaaagug cuuggggugu                                                   20


<210>  13128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13128
cuccacuauc uucagccucu                                                   20


<210>  13129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13129
acuaucuuca gccucucaga                                                   20


<210>  13130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13130
cagaugauca uggcaucagu                                                   20


<210>  13131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13131
gaugaucaug gcaucaguua                                                   20


<210>  13132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13132
gguaguuccu uauagcaaug                                                   20


<210>  13133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13133
cauugcuaua aggaacuacc                                                   20


<210>  13134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13134
uuugaagaua ccaaaaugcu                                                   20


<210>  13135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13135
augcuaagcu uuagcauuuu                                                   20


<210>  13136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13136
ccaugcuaag cuuuagcauu                                                   20


<210>  13137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13137
cuccaugcua agcuuuagca                                                   20


<210>  13138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13138
guuuucuuuc cuuuaaaaug                                                   20


<210>  13139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13139
uuuuaaagga aagaaaacug                                                   20


<210>  13140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13140
aaacuggggu aauagccuca                                                   20


<210>  13141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13141
uacccuuaau aaggugaaac                                                   20


<210>  13142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13142
uuuuaaagca uuguacucuu                                                   20


<210>  13143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13143
gucuggaaua uuuguauuau                                                   20


<210>  13144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13144
uccugguuuu uccaugucug                                                   20


<210>  13145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13145
guaagaaaua agaaaacuaa                                                   20


<210>  13146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13146
aggauauugu cuuuauuuuc                                                   20


<210>  13147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13147
cuugguaccc cuaaugucuc                                                   20


<210>  13148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13148
uucauucugu uucuccuccc                                                   20


<210>  13149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13149
ucccagccuc cuguuaccca                                                   20


<210>  13150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13150
cagccuccug uuacccaucu                                                   20


<210>  13151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13151
uguuacccau cuuucagaag                                                   20


<210>  13152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13152
caggucuucu gaaagauggg                                                   20


<210>  13153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13153
acacuggcca acugaaauca                                                   20


<210>  13154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13154
caggcuucuc caaccacaga                                                   20


<210>  13155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13155
aaccacagau augcaagaau                                                   20


<210>  13156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13156
acugacacuu ugaaaacauu                                                   20


<210>  13157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13157
ccacugacac uuugaaaaca                                                   20


<210>  13158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13158
guagaacuua ugcucuccac                                                   20


<210>  13159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13159
caaguuugug cucaguagaa                                                   20


<210>  13160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13160
ucauucauca gguaaaugcc                                                   20


<210>  13161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13161
ugugcaaggc ugcacuugcc                                                   20


<210>  13162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13162
ucuuguuaag uaguugaaug                                                   20


<210>  13163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13163
uuuauuauuu ugagaaguua                                                   20


<210>  13164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13164
aaauaauaaa cgaggguccc                                                   20


<210>  13165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13165
auuauuucac aggcaggaga                                                   20


<210>  13166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13166
ugccugugaa auaauggaga                                                   20


<210>  13167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13167
agauacaaua gggacuggcc                                                   20


<210>  13168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13168
uaaccauuuc caaugccaaa                                                   20


<210>  13169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13169
cauaaccauu uccaaugcca                                                   20


<210>  13170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13170
gugggaagcu cucauaacca                                                   20


<210>  13171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13171
gggcucagug ggaagcucuc                                                   20


<210>  13172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13172
aacuugacuc ugggcucagu                                                   20


<210>  13173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13173
ugugcagaaa ggagugggca                                                   20


<210>  13174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13174
uuucugcaca ggagaucucu                                                   20


<210>  13175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13175
gcuauauugc agaauaaugg                                                   20


<210>  13176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13176
auuuguacaa gauaggaugc                                                   20


<210>  13177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13177
gucugcugau ucugaccaug                                                   20


<210>  13178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13178
ugugucuugc uaagcacagg                                                   20


<210>  13179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13179
uccuucaggg guacuuuaua                                                   20


<210>  13180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13180
guauugcuua uaaaguaccc                                                   20


<210>  13181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13181
cuguauugcu uauaaaguac                                                   20


<210>  13182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13182
aaauucgaga uucaaacauu                                                   20


<210>  13183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13183
aauuuagagu uuaguuuaaa                                                   20


<210>  13184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13184
aaacaauuuu uuccccuaaa                                                   20


<210>  13185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13185
aaacagggaa agcucauuuc                                                   20


<210>  13186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13186
uuucacaguu uaaagaaaac                                                   20


<210>  13187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13187
agccuugaag ggagaggagg                                                   20


<210>  13188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13188
ggcaagagaa uauccucuuc                                                   20


<210>  13189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13189
ugccagaggg accuucccuc                                                   20


<210>  13190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13190
uccacccacu ggcugaugcu                                                   20


<210>  13191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13191
aaauucuacu auuaggacau                                                   20


<210>  13192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13192
ggguggggua auacuuaaac                                                   20


<210>  13193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13193
guggacugua aagggcugau                                                   20


<210>  13194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13194
ucgguggacu guaaagggcu                                                   20


<210>  13195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13195
uuccuccucg guggacugua                                                   20


<210>  13196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13196
ggguucagcc uuucuguucu                                                   20


<210>  13197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13197
uaaauuauua uaacaauacg                                                   20


<210>  13198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13198
uccaaaugaa uuuuguaaau                                                   20


<210>  13199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13199
cagagauuag ugauaaauca                                                   20


<210>  13200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13200
gugagguaga ucccacucuu                                                   20


<210>  13201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13201
uauugauauu cauuaaaaau                                                   20


<210>  13202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13202
cuggcuaggg aauagcucca                                                   20


<210>  13203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13203
ggcuagggaa uagcuccaua                                                   20


<210>  13204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13204
auaaugacuu ugugagcauu                                                   20


<210>  13205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13205
caaagucauu auggagcuau                                                   20


<210>  13206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13206
auauuuaguu caauagccuu                                                   20


<210>  13207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13207
cuuugauuug auucuauuug                                                   20


<210>  13208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13208
uccgaggagc ugggcuguag                                                   20


<210>  13209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13209
gaugagcaug ucaggcugga                                                   20


<210>  13210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13210
ucggaugagc augucaggcu                                                   20


<210>  13211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13211
ccuuccuagu cguagaaagg                                                   20


<210>  13212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13212
cuccccuucc uagucguaga                                                   20


<210>  13213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13213
cccuccccuu ccuagucgua                                                   20


<210>  13214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13214
ucucccuccc cuuccuaguc                                                   20


<210>  13215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13215
ccucucccuc cccuuccuag                                                   20


<210>  13216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13216
ucuccucucc cuccccuucc                                                   20


<210>  13217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13217
caucuccucu ccucucccuc                                                   20


<210>  13218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13218
gucuugcuuc ucccaucucc                                                   20


<210>  13219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13219
aguucagguc uaaagugggc                                                   20


<210>  13220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13220
caaauguaga cagaugccca                                                   20


<210>  13221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13221
agguuucuag aagagaagga                                                   20


<210>  13222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13222
ucuagaaacc uagagcuucu                                                   20


<210>  13223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13223
uucucuucua gaaaccuaga                                                   20


<210>  13224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13224
caccaauuuu ccccuccuuc                                                   20


<210>  13225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13225
aaaccucaca ccaauuuucc                                                   20


<210>  13226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13226
ccugcuguga ugcaggcagu                                                   20


<210>  13227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13227
ugcugugaug caggcaguca                                                   20


<210>  13228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13228
aaccuaacca ugcugacugc                                                   20


<210>  13229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13229
cugggacacc cggaugagag                                                   20


<210>  13230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13230
uccggguguc ccagggagcu                                                   20


<210>  13231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13231
cauccgggug ucccagggag                                                   20


<210>  13232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13232
cugacucuca uccggguguc                                                   20


<210>  13233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13233
gucuucuuug cagaaagccu                                                   20


<210>  13234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13234
gaucacuuuc ccuggugaaa                                                   20


<210>  13235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13235
cagaucacuu ucccugguga                                                   20


<210>  13236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13236
uuacuccaaa agaaagaagg                                                   20


<210>  13237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13237
aaaagaaaga aggucacagc                                                   20


<210>  13238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13238
uucuucugau aaugguuucg                                                   20


<210>  13239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13239
caguuugucu cuuucuucug                                                   20


<210>  13240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13240
gcacgucaca uggcacagau                                                   20


<210>  13241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13241
gaauacacuc agcacgucac                                                   20


<210>  13242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13242
gacauccauu uucuuuaagu                                                   20


<210>  13243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13243
cccaccuucc ucugacaucc                                                   20


<210>  13244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13244
uuuagugaau uauucauugg                                                   20


<210>  13245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13245
ccccagccuu cauuacucag                                                   20


<210>  13246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13246
gagcugucgc uguggauucu                                                   20


<210>  13247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13247
gaguaaugaa ggcuggggug                                                   20


<210>  13248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13248
uugucuuugg gaagggagag                                                   20


<210>  13249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13249
cuucccaaag acaaggagua                                                   20


<210>  13250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13250
cccuucccaa agacaaggag                                                   20


<210>  13251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13251
ucuagaaaua uuuccucucc                                                   20


<210>  13252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13252
caagacaccu uccucuuuuc                                                   20


<210>  13253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13253
uuucucucuc ucucuguuaa                                                   20


<210>  13254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13254
ugagaucuga ugguuuuacc                                                   20


<210>  13255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13255
cgagacuaau ucacaccacg                                                   20


<210>  13256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13256
uucucucuuu gccugcugcc                                                   20


<210>  13257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13257
cuuugccugc ugccauccau                                                   20


<210>  13258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13258
uugccugcug ccauccaugu                                                   20


<210>  13259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13259
uccuugccuu ccaucaugau                                                   20


<210>  13260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13260
uugccuucca ucaugauuau                                                   20


<210>  13261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13261
uaaucaugau ggaaggcaag                                                   20


<210>  13262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13262
caguuccaca cggcuaggga                                                   20


<210>  13263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13263
uucuuuugua aauugcccag                                                   20


<210>  13264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13264
ggcaauugug ucuuugucag                                                   20


<210>  13265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13265
cucuuggucu aaucccagac                                                   20


<210>  13266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13266
uggucuaauc ccagacaacc                                                   20


<210>  13267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13267
gaaaaagugu uggguugucu                                                   20


<210>  13268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13268
uuuguuuugu uguuuguuug                                                   20


<210>  13269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13269
cccaaccuac cccuuuccac                                                   20


<210>  13270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13270
guuaaugacc acccuucauc                                                   20


<210>  13271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13271
cuguuaauga ccacccuuca                                                   20


<210>  13272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13272
gucucucugu uaaugaccac                                                   20


<210>  13273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13273
cugucucucu guuaaugacc                                                   20


<210>  13274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13274
ucucucuguc ucucuguuaa                                                   20


<210>  13275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13275
ugaggugaac cuagaagacc                                                   20


<210>  13276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13276
agaggcacau gucagccucu                                                   20


<210>  13277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13277
aaauauguaa uucuugaugg                                                   20


<210>  13278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13278
uggcuaugca uaugcaauau                                                   20


<210>  13279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13279
aauuggaauu aaaaauuacu                                                   20


<210>  13280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13280
guuuuugagc acuguguucu                                                   20


<210>  13281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13281
aaaacagagu cagaagaucu                                                   20


<210>  13282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13282
gagagcauuc uguaaucaca                                                   20


<210>  13283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13283
gaggcacagc agaagcaaau                                                   20


<210>  13284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13284
cagaggcaca gcagaagcaa                                                   20


<210>  13285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13285
uugaaaauca cagucugcca                                                   20


<210>  13286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13286
uggcgagugg aaaacuuacc                                                   20


<210>  13287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13287
ccaggagacg acggaauuua                                                   20


<210>  13288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13288
uuaccccagu uuuuagggua                                                   20


<210>  13289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13289
acagguuucc uguaugugca                                                   20


<210>  13290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13290
auuucaagug gcuuugcaca                                                   20


<210>  13291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13291
guugacacau acucaauuuc                                                   20


<210>  13292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13292
cagccaggac cuauuggaaa                                                   20


<210>  13293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13293
uuugucccaa cuuucuggga                                                   20


<210>  13294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13294
gcaggagaga aagugccuuu                                                   20


<210>  13295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13295
ugcugagaaa uuaacaccuu                                                   20


<210>  13296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13296
ccugcugaga aauuaacacc                                                   20


<210>  13297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13297
aucaccaggc ccuaagccau                                                   20


<210>  13298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13298
uacaaaaggg uaaucauaua                                                   20


<210>  13299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13299
uggcuuucuc cuacaaaagg                                                   20


<210>  13300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13300
uaaacuuccc agucucuugg                                                   20


<210>  13301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13301
aagauuauac ucugauuacu                                                   20


<210>  13302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13302
auuaugauca cauccaguuc                                                   20


<210>  13303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13303
uaacagugua cuacauaauu                                                   20


<210>  13304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13304
cagaagacug cugcauacau                                                   20


<210>  13305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13305
ccaaguccaa ucagcuacaa                                                   20


<210>  13306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13306
gacccaaucu auacccccuu                                                   20


<210>  13307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13307
uagaacaggu cugggcacac                                                   20


<210>  13308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13308
gaagaauaaa acuugacaug                                                   20


<210>  13309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13309
aaugguuuug caugucaagu                                                   20


<210>  13310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13310
auuacuuauu acuguauauu                                                   20


<210>  13311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13311
aguccccaag ggaugugcuu                                                   20


<210>  13312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13312
cacuaacuag uugaagcaag                                                   20


<210>  13313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13313
cuaacuaguu gaagcaagug                                                   20


<210>  13314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13314
uucaucuaug cuacuguuuu                                                   20


<210>  13315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13315
uuuaucuuga ucacuaguua                                                   20


<210>  13316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13316
cccuccuucu aucuuguugc                                                   20


<210>  13317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13317
uucuaucuug uugcuccauu                                                   20


<210>  13318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13318
auuauucuua auacacagcu                                                   20


<210>  13319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13319
ugguccaaca uggcugcuca                                                   20


<210>  13320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13320
uuaaggacac uuccuuggag                                                   20


<210>  13321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13321
aaggaagugu ccuuaaagag                                                   20


<210>  13322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13322
uaaauucuaa ccaauagguu                                                   20


<210>  13323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13323
cuugcagugu gguguggcca                                                   20


<210>  13324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13324
aguuccuuug aggaagacug                                                   20


<210>  13325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13325
aaggaacuug aguucugugg                                                   20


<210>  13326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13326
cagugaaguc acuagaaaug                                                   20


<210>  13327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13327
ucugguugca agugauagag                                                   20


<210>  13328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13328
aucacuugca accagaagag                                                   20


<210>  13329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13329
gucucagucu uggacucugc                                                   20


<210>  13330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13330
gucuuggacu cugcuucucu                                                   20


<210>  13331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13331
gcuucucucu gggacuggca                                                   20


<210>  13332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13332
cugggacugg caucauuccc                                                   20


<210>  13333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13333
gggacuggca ucauucccag                                                   20


<210>  13334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13334
gcuggaccag aguugacuuu                                                   20


<210>  13335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13335
aagauguaua aaucaccucu                                                   20


<210>  13336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13336
gacuggccug gagcugggug                                                   20


<210>  13337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13337
aggccaguca gagacaccau                                                   20


<210>  13338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13338
aaccauaaca caacagaagc                                                   20


<210>  13339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13339
cccccugucc ccuaggcugu                                                   20


<210>  13340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13340
ucagucagau gcuucugcau                                                   20


<210>  13341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13341
agaaacacga caugacuacc                                                   20


<210>  13342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13342
gaggaccugc augccugcag                                                   20


<210>  13343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13343
gaggcuuucu ccagaaacac                                                   20


<210>  13344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13344
gcaggcaugc agguccucag                                                   20


<210>  13345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13345
ucucccaucu ccuacaccua                                                   20


<210>  13346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13346
caucuccuac accuagucca                                                   20


<210>  13347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13347
uuaacaggac caggagcaaa                                                   20


<210>  13348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13348
ugguccuguu aaugagcaua                                                   20


<210>  13349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13349
auuggugauc agcguguauu                                                   20


<210>  13350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13350
guaugugucg caugcucugc                                                   20


<210>  13351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13351
gcugaaacca gcuuucugaa                                                   20


<210>  13352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13352
gccuucagaa agcugguuuc                                                   20


<210>  13353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13353
uucuuugcuu uacauuuuaa                                                   20


<210>  13354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13354
ccuucagauc auggugagau                                                   20


<210>  13355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13355
uucagaucau ggugagauuc                                                   20


<210>  13356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13356
ccaugaucug aaggagaggu                                                   20


<210>  13357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13357
aaauaaauaa auaaaauuau                                                   20


<210>  13358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13358
caucuguaau cccagcacuu                                                   20


<210>  13359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13359
agggccccac ccucuauuuu                                                   20


<210>  13360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13360
auuuuuacuu ugaaagauaa                                                   20


<210>  13361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13361
uucccuacac cucacagcug                                                   20


<210>  13362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13362
cagcugggau uugagcacag                                                   20


<210>  13363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13363
aaucccagcu gugaggugua                                                   20


<210>  13364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13364
acaucuauag agguacaucu                                                   20


<210>  13365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13365
auagaugugg agggucggau                                                   20


<210>  13366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13366
cuuuaaucca ugugaccugu                                                   20


<210>  13367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13367
cugggccugu uuccucaccu                                                   20


<210>  13368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13368
ccuauaaaaa ggaagugaua                                                   20


<210>  13369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13369
aacacuuauu aauaaguguu                                                   20


<210>  13370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13370
uggccuaguc acaacagauu                                                   20


<210>  13371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13371
augcuaaaca aucaaucuug                                                   20


<210>  13372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13372
gcaggugauu cugaugagua                                                   20


<210>  13373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13373
ucagaaucac cugcagagcu                                                   20


<210>  13374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13374
gaaucggaga uuucaaaacu                                                   20


<210>  13375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13375
gauucugagu cccggcuacu                                                   20


<210>  13376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13376
aucagaacuu gacaaaugac                                                   20


<210>  13377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13377
aaaauauaug cuacaugauc                                                   20


<210>  13378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13378
auacuggcaa auuuuugucu                                                   20


<210>  13379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13379
aauccacugu caaaagacaa                                                   20


<210>  13380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13380
cugaauaugc ugggccauuu                                                   20


<210>  13381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13381
ugcgccucau aauugacaca                                                   20


<210>  13382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13382
uaauugacac aaaaagcaau                                                   20


<210>  13383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13383
uuuggaauug cuuuuugugu                                                   20


<210>  13384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13384
aauacagcug uuacuaauaa                                                   20


<210>  13385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13385
ccaaagcacu gucauuaaaa                                                   20


<210>  13386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13386
cacauccaga ucaacauugu                                                   20


<210>  13387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13387
uuauguacgg gucaaacccg                                                   20


<210>  13388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13388
caccacuguu cccccuuuca                                                   20


<210>  13389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13389
guucagggac accagacuuu                                                   20


<210>  13390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13390
ggaaacucug caaccaggug                                                   20


<210>  13391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13391
gcaaccaggu gagaugauuc                                                   20


<210>  13392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13392
ccugguugca gaguuuccug                                                   20


<210>  13393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13393
aaacccucau aaugaaauuc                                                   20


<210>  13394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13394
uaaugaaauu cccucacauu                                                   20


<210>  13395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13395
cauucuauca gauaaauccu                                                   20


<210>  13396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13396
ccaguuagga uuuaucugau                                                   20


<210>  13397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13397
caccaguuag gauuuaucug                                                   20


<210>  13398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13398
aacaucuugc aguuauuuuc                                                   20


<210>  13399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13399
ucugggaaag aaaauaacug                                                   20


<210>  13400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13400
uaccucccga aucugcugug                                                   20


<210>  13401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13401
cgaaucugcu guggacauua                                                   20


<210>  13402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13402
auccuacaga cagaagacuc                                                   20


<210>  13403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13403
uuaguuucca aaccuaugac                                                   20


<210>  13404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13404
gagccauuca aaugcugaug                                                   20


<210>  13405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13405
gagaagcccu uacaugaaga                                                   20


<210>  13406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13406
ucuccuacug uuuuaggcau                                                   20


<210>  13407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13407
ccuacuguuu uaggcauuuu                                                   20


<210>  13408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13408
uacuguuuua ggcauuuuga                                                   20


<210>  13409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13409
ucuccucugc cucuaacauu                                                   20


<210>  13410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13410
ucugccucua acauuucaga                                                   20


<210>  13411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13411
gccucuaaca uuucagaaua                                                   20


<210>  13412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13412
aacauuucag aauauaaguc                                                   20


<210>  13413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13413
aaauacaugu uuuaaaagcc                                                   20


<210>  13414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13414
gaaaguaaca agcauucacc                                                   20


<210>  13415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13415
uaaggugaau gcuuguuacu                                                   20


<210>  13416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13416
ucugugauuc uuaagaauaa                                                   20


<210>  13417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13417
aucugccuuc acaccucccu                                                   20


<210>  13418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13418
cuuuaacccc uccaacaggg                                                   20


<210>  13419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13419
aacagggcga gaagccucuu                                                   20


<210>  13420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13420
cccuguugga gggguuaaag                                                   20


<210>  13421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13421
ugcguggggc cuugcuuucc                                                   20


<210>  13422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13422
gugcugguuu cagagacauc                                                   20


<210>  13423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13423
gaaaccagca cugagacaaa                                                   20


<210>  13424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13424
guucucaggg agcuaacuuu                                                   20


<210>  13425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13425
gggagcuaac uuuagcagca                                                   20


<210>  13426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13426
cugagaacag agcuggaugg                                                   20


<210>  13427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13427
gccagcagau gcagaaucug                                                   20


<210>  13428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13428
cucucgugug aggacauuua                                                   20


<210>  13429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13429
cucgugugag gacauuuaau                                                   20


<210>  13430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13430
cgugugagga cauuuaauau                                                   20


<210>  13431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13431
ugugaggaca uuuaauauau                                                   20


<210>  13432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13432
cacgagagag agucagccau                                                   20


<210>  13433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13433
ggauauauua aauguccuca                                                   20


<210>  13434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13434
agauaggacu gcuuguuaac                                                   20


<210>  13435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13435
gauuucuccu cugggcaggc                                                   20


<210>  13436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13436
ucugggcagg ccagcaaauu                                                   20


<210>  13437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13437
gggcaggcca gcaaauuuau                                                   20


<210>  13438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13438
ccuuucucca aauaaagucu                                                   20


<210>  13439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13439
aaauaaaguc uuucuuucau                                                   20


<210>  13440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13440
cugacucucc cauuaaccuu                                                   20


<210>  13441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13441
cccauuaacc uuuuaaccac                                                   20


<210>  13442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13442
cauuaaccuu uuaaccacuu                                                   20


<210>  13443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13443
agugguuaaa agguuaaugg                                                   20


<210>  13444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13444
ucaagugguu aaaagguuaa                                                   20


<210>  13445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13445
cuucaaaagg cggaguuuca                                                   20


<210>  13446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13446
ucaaaaggcg gaguuucauu                                                   20


<210>  13447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13447
gccuuuugaa gagagaagug                                                   20


<210>  13448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13448
uuguuuuucu cggaucacuc                                                   20


<210>  13449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13449
caagcagcug gggcuacagg                                                   20


<210>  13450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13450
gccucccaag cagcuggggc                                                   20


<210>  13451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13451
ugccucagcc ucccaagcag                                                   20


<210>  13452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13452
uggguucaag caauucuccu                                                   20


<210>  13453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13453
gccuccuggg uucaagcaau                                                   20


<210>  13454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13454
ccacagaaag gaaggcugug                                                   20


<210>  13455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13455
ugguggcagc cuccccacag                                                   20


<210>  13456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13456
uuguuauagg ggccaagaaa                                                   20


<210>  13457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13457
uucucugagu ggggaaguuc                                                   20


<210>  13458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13458
gaguggggaa guucucaagu                                                   20


<210>  13459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13459
gagaaagagu caucucauug                                                   20


<210>  13460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13460
aguuuuaauc uuaauagccc                                                   20


<210>  13461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13461
agaugggccc uuuuuggaag                                                   20


<210>  13462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13462
aacuuucaaa auccucacaa                                                   20


<210>  13463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13463
caaaugcauu gugcagcaca                                                   20


<210>  13464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13464
ucaggaugcu gggguucugu                                                   20


<210>  13465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13465
caaugaccac agaaccccag                                                   20


<210>  13466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13466
ggcauuucuc ccaaugacca                                                   20


<210>  13467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13467
acuauuggac uucuccaggc                                                   20


<210>  13468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13468
aggccuuuaa uauggaaugu                                                   20


<210>  13469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13469
auauaauacu auuucuauga                                                   20


<210>  13470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13470
cccagcauuu uacaaaauau                                                   20


<210>  13471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13471
ccaaggacag aaagaauaag                                                   20


<210>  13472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13472
gucuaggcau cccaggcuuu                                                   20


<210>  13473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13473
gaugauucuc ugucuaggca                                                   20


<210>  13474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13474
gcucugauga uucucugucu                                                   20


<210>  13475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13475
gaaaugaagg aaggugagag                                                   20


<210>  13476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13476
ccuuccuuca uuucagaguc                                                   20


<210>  13477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13477
caccuuccuu cauuucagag                                                   20


<210>  13478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13478
ucucucaccu uccuucauuu                                                   20


<210>  13479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13479
cucaucucuc accuuccuuc                                                   20


<210>  13480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13480
cccucccuca ucucucaccu                                                   20


<210>  13481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13481
cccccucccu caucucucac                                                   20


<210>  13482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13482
cucccccucc cucaucucuc                                                   20


<210>  13483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13483
aaagcagcag agucauugaa                                                   20


<210>  13484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13484
gcugcuuuug aguuguuaga                                                   20


<210>  13485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13485
ucaauuacuu cuuguuggcc                                                   20


<210>  13486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13486
auuacuucuu guuggccaga                                                   20


<210>  13487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13487
aagauaguaa acuuuaucau                                                   20


<210>  13488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13488
guaugauaaa guuuacuauc                                                   20


<210>  13489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13489
ugaccucugu augauaaagu                                                   20


<210>  13490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13490
acuagauaau uuuucacagu                                                   20


<210>  13491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13491
guuuauuaua acgugugggu                                                   20


<210>  13492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13492
cuauaaaacc acuuacuagg                                                   20


<210>  13493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13493
ugcacagaaa gucaaaucag                                                   20


<210>  13494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13494
uaaaggagag guagcacaug                                                   20


<210>  13495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13495
uuuaagagca cguccuuuua                                                   20


<210>  13496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13496
ccuuuaagag cacguccuuu                                                   20


<210>  13497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13497
cuuucccaca cguacacaag                                                   20


<210>  13498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13498
cugcaugcca gagacacuca                                                   20


<210>  13499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13499
gcaugccaga gacacucaaa                                                   20


<210>  13500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13500
ggcaugcaga gaggcgaugg                                                   20


<210>  13501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13501
aaagaauccu ucucaguagu                                                   20


<210>  13502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13502
guagucucgu uucuuuuaca                                                   20


<210>  13503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13503
uuucuuuuac agcugaguau                                                   20


<210>  13504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13504
gcuguaaaag aaacgagacu                                                   20


<210>  13505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13505
agauacuaua ggugccagcc                                                   20


<210>  13506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13506
caaauacuag ucaugguauu                                                   20


<210>  13507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13507
aauacuaguc augguauuuu                                                   20


<210>  13508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13508
agggaaaaaa auaccaugac                                                   20


<210>  13509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13509
uucaauauua ugacucuagg                                                   20


<210>  13510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13510
caagagucac ggauuuaaua                                                   20


<210>  13511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13511
agagucacgg auuuaauauu                                                   20


<210>  13512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13512
ugagagcauu ugcuggggaa                                                   20


<210>  13513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13513
ggcuguaaua uuaaauccgu                                                   20


<210>  13514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13514
caggcuguaa uauuaaaucc                                                   20


<210>  13515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13515
cucaggcugu aauauuaaau                                                   20


<210>  13516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13516
aaccuuggau uuuucuaaga                                                   20


<210>  13517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13517
cucccacagu aauggcuuca                                                   20


<210>  13518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13518
cccacaguaa uggcuucaug                                                   20


<210>  13519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13519
cacaguaaug gcuucauggu                                                   20


<210>  13520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13520
cccugaauug ucccuaggga                                                   20


<210>  13521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13521
cucacccuga auugucccua                                                   20


<210>  13522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13522
ggguucacaa uccuaucccc                                                   20


<210>  13523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13523
cauucuuuaa cuugucuuuc                                                   20


<210>  13524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13524
uuagaauuca cuucuuccaa                                                   20


<210>  13525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13525
uagacuuguu ggacuauugg                                                   20


<210>  13526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13526
aaaguauugu ugauuuccuu                                                   20


<210>  13527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13527
ccacaaaaau cugcugaaua                                                   20


<210>  13528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13528
auauuuauuc agcagauuuu                                                   20


<210>  13529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13529
auuuuguauu ggaaucauaa                                                   20


<210>  13530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13530
uuauucuucc aaauccucua                                                   20


<210>  13531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13531
ccagccaggg auaagaacua                                                   20


<210>  13532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13532
cuuccucccu ucuuguguau                                                   20


<210>  13533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13533
cucccuuccu cccuucuugu                                                   20


<210>  13534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13534
cucccucccu uccucccuuc                                                   20


<210>  13535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13535
cuuccucccu cccucccuuc                                                   20


<210>  13536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13536
cccuuccucc cucccucccu                                                   20


<210>  13537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13537
aacucucccu uccucccucc                                                   20


<210>  13538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13538
cuccaacucu cccuuccucc                                                   20


<210>  13539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13539
cucccuccaa cucucccuuc                                                   20


<210>  13540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13540
cucccucccu ccaacucucc                                                   20


<210>  13541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13541
cucccucccu cccuccaacu                                                   20


<210>  13542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13542
cuuuuuuccu uccuuccuuc                                                   20


<210>  13543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13543
cucccuuuuu uccuuccuuc                                                   20


<210>  13544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13544
uauugguccc caagcauacg                                                   20


<210>  13545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13545
agguaaagaa aauuuguaca                                                   20


<210>  13546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13546
gaagucaacu caaggaaccc                                                   20


<210>  13547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13547
aggaacccaa aauacaacca                                                   20


<210>  13548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13548
gguaccauuu ccuuuucgga                                                   20


<210>  13549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13549
cuaaucuuua ugcuucaacu                                                   20


<210>  13550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13550
cacuaaucuu uaugcuucaa                                                   20


<210>  13551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13551
ugcaugcugg cuuuucuucc                                                   20


<210>  13552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13552
uggcccucgu gcaugcuggc                                                   20


<210>  13553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13553
augcuuuccc aauccuccug                                                   20


<210>  13554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13554
guggccacuc caugcuuucc                                                   20


<210>  13555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13555
guggcucaug ccuguaaucc                                                   20


<210>  13556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13556
ugccuguaau ccuagcacuu                                                   20


<210>  13557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13557
agugaucugc ccaccuuggc                                                   20


<210>  13558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13558
gaaguuugag accagccuga                                                   20


<210>  13559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13559
aacuucugag cucaagugau                                                   20


<210>  13560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13560
guuucucucc acauggucau                                                   20


<210>  13561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13561
ccacaugguc augucugugg                                                   20


<210>  13562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13562
acauggucau gucugugggc                                                   20


<210>  13563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13563
cagcauggug gcugcaucac                                                   20


<210>  13564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13564
gucuucacau ggccuucuuc                                                   20


<210>  13565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13565
gccucagucu ucacauggcc                                                   20


<210>  13566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13566
uccagcuucu ggugacuucu                                                   20


<210>  13567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13567
guguugccac cucccguggg                                                   20


<210>  13568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13568
cgugggggcu gcaucaggug                                                   20


<210>  13569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13569
uugauucaau caccccaagu                                                   20


<210>  13570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13570
uuucucuuug auucaaucac                                                   20


<210>  13571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13571
ccuuucucuu ugauucaauc                                                   20


<210>  13572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13572
acucuccuuu cucuuugauu                                                   20


<210>  13573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13573
agagugcaca gcugaaggga                                                   20


<210>  13574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13574
agagaagucu auuagaaacu                                                   20


<210>  13575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13575
ucccuucagc ugugcacucu                                                   20


<210>  13576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13576
cucugcuucc uaauagacua                                                   20


<210>  13577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13577
gcuuccuaau agacuaacaa                                                   20


<210>  13578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13578
cuaaaucuuc uucggagacc                                                   20


<210>  13579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13579
aaaucuucuu cggagacccc                                                   20


<210>  13580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13580
gaagaagauu uagagagguu                                                   20


<210>  13581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13581
uucguucgag agccaaaaug                                                   20


<210>  13582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13582
aacgaaagag caacuggcgg                                                   20


<210>  13583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13583
cgaacgaaag agcaacuggc                                                   20


<210>  13584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13584
uuuuggcucu cgaacgaaag                                                   20


<210>  13585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13585
cauggucgua gauagcaguc                                                   20


<210>  13586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13586
uggucguaga uagcaguccc                                                   20


<210>  13587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13587
gguugaucag ggacugcuau                                                   20


<210>  13588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13588
uuuaauuggc cuccgguuga                                                   20


<210>  13589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13589
cuuuuaauug gccuccgguu                                                   20


<210>  13590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13590
uccaaauauu uccacuucgc                                                   20


<210>  13591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13591
aaauggauuc caaacagucc                                                   20


<210>  13592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13592
gggaugcuuu caauuccuuu                                                   20


<210>  13593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13593
cacccuuccu ugcaaagcuu                                                   20


<210>  13594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13594
cccuuccuug caaagcuuaa                                                   20


<210>  13595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13595
guuugguuac ccaccgcccc                                                   20


<210>  13596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13596
uccucuccac accccaugau                                                   20


<210>  13597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13597
ucuccacacc ccaugauagg                                                   20


<210>  13598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13598
ccacacccca ugauagggua                                                   20


<210>  13599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13599
acaccccaug auaggguacu                                                   20


<210>  13600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13600
ggucccuccu ggccagggcu                                                   20


<210>  13601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13601
uggccagggc uaguaaagaa                                                   20


<210>  13602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13602
acaccuuuca ggaaaacuac                                                   20


<210>  13603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13603
aaggacuuau ccacaguggu                                                   20


<210>  13604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13604
acaugaggag aagaagaugg                                                   20


<210>  13605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13605
uguugaguuc ucuaaggacu                                                   20


<210>  13606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13606
ucauguugag uucucuaagg                                                   20


<210>  13607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13607
aucuucuucu ccucauguug                                                   20


<210>  13608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13608
cuucugauuc cuuucuccau                                                   20


<210>  13609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13609
ccugcaccau ccuucaggga                                                   20


<210>  13610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13610
uugccuuuuu uuuuugccuc                                                   20


<210>  13611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13611
ucuuugccuu uuuuuuuugc                                                   20


<210>  13612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13612
cuccucuuug ccuuuuuuuu                                                   20


<210>  13613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13613
cccuccucuu ugccuuuuuu                                                   20


<210>  13614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13614
uucaccacuu ucucucccuc                                                   20


<210>  13615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13615
accuuucuau accagucucu                                                   20


<210>  13616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence CTCN PAM

<400>  13616
aaaucaaggc caauuuuuua                                                   20


<210>  13617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13617
ucuccaacgc agcaucugug                                                   20


<210>  13618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13618
uccacccacg cccacgccca                                                   20


<210>  13619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13619
cuauuauuuc cuugcgugug                                                   20


<210>  13620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13620
cagauacuug ugaggcugag                                                   20


<210>  13621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13621
cgaacuccug gccucaagug                                                   20


<210>  13622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13622
ugagccacca cacucggcug                                                   20


<210>  13623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13623
gaguuauuuu uaauaaguaa                                                   20


<210>  13624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13624
aaguauaagg aacccccuga                                                   20


<210>  13625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13625
gauagaccug gauucaaauu                                                   20


<210>  13626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13626
aucagacacc auguaucugu                                                   20


<210>  13627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13627
gaauuugaau ccaggucuau                                                   20


<210>  13628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13628
uguaacuagg aaguugcaga                                                   20


<210>  13629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13629
aagaaauuga guaauuuucc                                                   20


<210>  13630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13630
ucugaagaaa uagagauaau                                                   20


<210>  13631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13631
cuaccuauag caacuuaaga                                                   20


<210>  13632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13632
uacacugugu uaaagccuuc                                                   20


<210>  13633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13633
guaaauacua gcauuauuca                                                   20


<210>  13634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13634
aagaccuaag gacuaaauuc                                                   20


<210>  13635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13635
uggacuuuuu uuuuaaguau                                                   20


<210>  13636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13636
uuaggucuug gacuuuuuuu                                                   20


<210>  13637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13637
ccacuucucc ccacaugauu                                                   20


<210>  13638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13638
ggagaguuaa agaacauguu                                                   20


<210>  13639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13639
cccuggcccu gguguuuuuu                                                   20


<210>  13640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13640
uuucuuuauu uccugugcca                                                   20


<210>  13641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13641
aagaucucug uuuacuagau                                                   20


<210>  13642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13642
cuucccuuga gacuggcaag                                                   20


<210>  13643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13643
caagggaaga gacuauccuu                                                   20


<210>  13644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13644
gaaguuuguu gguuguuuug                                                   20


<210>  13645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13645
uguuuuguuu uguucuaauc                                                   20


<210>  13646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13646
ucuuugcuug gauuagaaca                                                   20


<210>  13647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13647
uuccagugug ccuuuccacu                                                   20


<210>  13648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13648
ggcuuucaga aucucuucuu                                                   20


<210>  13649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13649
uaagaagaga uucugaaagc                                                   20


<210>  13650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13650
cucacaauug uccuaagaag                                                   20


<210>  13651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13651
ugcugcuuca agcaacccuu                                                   20


<210>  13652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13652
acccaacgca cagcauggau                                                   20


<210>  13653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13653
aguguuaaug cgcacuggga                                                   20


<210>  13654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13654
aagguacucu ggguggaggg                                                   20


<210>  13655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13655
uucuucuuga aauucuccag                                                   20


<210>  13656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13656
guuugagcuu uuuuuuuuuu                                                   20


<210>  13657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13657
auacaaucua caacauauac                                                   20


<210>  13658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13658
ccugcuaauc cugagaacau                                                   20


<210>  13659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13659
uccgauuguc aaaacuugac                                                   20


<210>  13660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13660
aaacuugacc ccuccuuuga                                                   20


<210>  13661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13661
aguuuugaca aucggaggac                                                   20


<210>  13662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13662
aggguacacu uggagaacau                                                   20


<210>  13663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13663
caauggccuu auguucucca                                                   20


<210>  13664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13664
cugucucaau ggccuuaugu                                                   20


<210>  13665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13665
gucccugucu caauggccuu                                                   20


<210>  13666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13666
caaugcacag auaggucggu                                                   20


<210>  13667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13667
ugccauagca uuuaggaauu                                                   20


<210>  13668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13668
cucacucaau aauuccuaaa                                                   20


<210>  13669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13669
augucuuggc uguuguacaa                                                   20


<210>  13670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13670
uggcuguugu acaaaacaca                                                   20


<210>  13671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13671
aacuucccau ucaaugcucg                                                   20


<210>  13672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13672
cuuccaguuc uggccuucca                                                   20


<210>  13673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13673
uagagcugau ccagguuucu                                                   20


<210>  13674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13674
ggguuuuuug uuauuguuug                                                   20


<210>  13675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13675
uuuguaccuu uuaauuacaa                                                   20


<210>  13676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13676
uucaaagcuc cuuuaugccc                                                   20


<210>  13677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13677
ugccuggagc ugaaagcacg                                                   20


<210>  13678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13678
gaggaaguga gagugcaggg                                                   20


<210>  13679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13679
ccugauuccu agcccaugau                                                   20


<210>  13680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13680
ccaacuugcu gugcaacccu                                                   20


<210>  13681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13681
uguugagggu ugcacagcaa                                                   20


<210>  13682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13682
cuuccagccu cagcugugca                                                   20


<210>  13683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13683
gcacagcuga ggcuggaagg                                                   20


<210>  13684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13684
agggggagug caggugccuu                                                   20


<210>  13685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13685
cacaacauug caugagcauc                                                   20


<210>  13686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13686
ugcuucgggc aggcagcugc                                                   20


<210>  13687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13687
agagaagccu aagugagguc                                                   20


<210>  13688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13688
ccuugaugau ccagauaugg                                                   20


<210>  13689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13689
ugggauccau aucuggauca                                                   20


<210>  13690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13690
uuagguguca ugggauccau                                                   20


<210>  13691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13691
agccucccua gauguguccu                                                   20


<210>  13692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13692
ggcagagagg aauggagagg                                                   20


<210>  13693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13693
caucucuccu guuucuaaca                                                   20


<210>  13694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13694
uggaggugcc uuccagguca                                                   20


<210>  13695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13695
acccucuuug ucuacagauu                                                   20


<210>  13696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13696
acagauucag aaacugaguc                                                   20


<210>  13697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13697
agagagagga agucacucac                                                   20


<210>  13698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13698
cucacuuggg gcaugcagcu                                                   20


<210>  13699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13699
ucaauggcaa gccacucaac                                                   20


<210>  13700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13700
cagagaagcc agccagggcu                                                   20


<210>  13701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13701
gcacguccac agugcagcag                                                   20


<210>  13702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13702
acagugcagc aggugcccag                                                   20


<210>  13703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13703
uggcugggca ccugcugcac                                                   20


<210>  13704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13704
agagucuugg cugggcaccu                                                   20


<210>  13705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13705
accacccggu guuccuggcu                                                   20


<210>  13706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13706
ugcuuacaac aguugcaaga                                                   20


<210>  13707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13707
ucagcugacc aguguucagg                                                   20


<210>  13708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13708
gcugaagaca acgcugccac                                                   20


<210>  13709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13709
ggccugaauu cagaccacaa                                                   20


<210>  13710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13710
gaauucaggc ccgacuccca                                                   20


<210>  13711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13711
aaauccucuc uucuuugaaa                                                   20


<210>  13712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13712
ccauccucug aacagcuugc                                                   20


<210>  13713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13713
ugaguucugg gcugccgcuu                                                   20


<210>  13714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13714
ugggaccaaa ggcugggcgu                                                   20


<210>  13715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13715
caugaccuca ggcacaugcg                                                   20


<210>  13716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13716
ucaagaggag caggauguuc                                                   20


<210>  13717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13717
acaggcaagu aaguuguuau                                                   20


<210>  13718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13718
uuugggggga ggaacuggaa                                                   20


<210>  13719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13719
gacaucccuc auguccccau                                                   20


<210>  13720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13720
gacaggagaa acaagcauuu                                                   20


<210>  13721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13721
ccaugccagc acccccaggc                                                   20


<210>  13722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13722
gcaacucugc caccuuacac                                                   20


<210>  13723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13723
uuucggugga cuccacacug                                                   20


<210>  13724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13724
accgaaacga cccucaagcc                                                   20


<210>  13725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13725
gugaggcagu guggagucca                                                   20


<210>  13726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13726
uagccagcug ugcugcaccu                                                   20


<210>  13727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13727
ugccuugcau ccucccuccc                                                   20


<210>  13728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13728
ucauguuuuu cccucuuugg                                                   20


<210>  13729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13729
gaacauaucc auagaggagg                                                   20


<210>  13730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13730
gaaagggccc ugggauaaau                                                   20


<210>  13731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13731
acacgcauca ccugccaccc                                                   20


<210>  13732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13732
cccagggacu cccuccagcu                                                   20


<210>  13733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13733
cugggggacg aguugggugg                                                   20


<210>  13734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13734
ccuggccuuu cccagagcug                                                   20


<210>  13735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13735
gaguaaguaa aaccagaaac                                                   20


<210>  13736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13736
agcaacacag uggcauuugc                                                   20


<210>  13737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13737
ggaaauuaua ggaucuuucu                                                   20


<210>  13738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13738
uggucaauaa uaauccgaga                                                   20


<210>  13739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13739
auaauaaucc gagagaaacc                                                   20


<210>  13740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13740
gcccccgccu ggccccagcu                                                   20


<210>  13741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13741
cacagugaca uuaacccagc                                                   20


<210>  13742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13742
cugugagacc cuuagccguu                                                   20


<210>  13743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13743
guaagaaacc cagaacuuga                                                   20


<210>  13744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13744
aauuucaaag cuacaauagg                                                   20


<210>  13745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13745
cacuucaggu cagagauuag                                                   20


<210>  13746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13746
gagauuagaa cuuccaagcu                                                   20


<210>  13747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13747
augcugaagc acgcuggugc                                                   20


<210>  13748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13748
auggagugga aaauucuaaa                                                   20


<210>  13749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13749
aagauucuua ugucaaggca                                                   20


<210>  13750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13750
aggcagaaga auagagcaca                                                   20


<210>  13751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13751
ugugacaggu ggauguccau                                                   20


<210>  13752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13752
caugacuaaa uuguuuaacc                                                   20


<210>  13753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13753
auuucuacuc uuauucuacu                                                   20


<210>  13754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13754
gcuggcugac caguucccaa                                                   20


<210>  13755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13755
gccagccgac caucaagaga                                                   20


<210>  13756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13756
ggauggcaau cccacagacu                                                   20


<210>  13757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13757
gugggauugc cauccugacu                                                   20


<210>  13758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13758
cauucuucaa cuacaccacc                                                   20


<210>  13759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13759
gugaggggug gaagguauca                                                   20


<210>  13760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13760
uuccacaagg caaagcuggu                                                   20


<210>  13761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13761
ccaggugaug aaaacaguca                                                   20


<210>  13762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13762
cuccacucuu guaaaccugu                                                   20


<210>  13763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13763
gugcauucca aagaaugccu                                                   20


<210>  13764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13764
gcucuaagug caacacccuc                                                   20


<210>  13765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13765
cucuuccagg caucuagccu                                                   20


<210>  13766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13766
uauucuaaac cuuuuccaug                                                   20


<210>  13767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13767
ccaguauuaa uguuuaucaa                                                   20


<210>  13768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13768
uaacuaagag cacagauuua                                                   20


<210>  13769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13769
uaaaucugug cucuuaguua                                                   20


<210>  13770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13770
uauugccuca gaggacuggc                                                   20


<210>  13771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13771
ucugaggcaa uaugacuguu                                                   20


<210>  13772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13772
cugugccagu ccucugaggc                                                   20


<210>  13773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13773
ggcaugucca gauuccccag                                                   20


<210>  13774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13774
agauucccca guaaagguua                                                   20


<210>  13775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13775
uuuuuccuuu ucagauaaua                                                   20


<210>  13776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13776
cuccagagga aaccacuguu                                                   20


<210>  13777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13777
guagcauggc agguuugauu                                                   20


<210>  13778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13778
uuaugaauca aaccugccau                                                   20


<210>  13779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13779
uacauuacau cucagguagc                                                   20


<210>  13780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13780
ggaugcaggc cacaagccac                                                   20


<210>  13781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13781
ccauauuuac uuccuguucc                                                   20


<210>  13782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13782
agaugcauga auaaaaauac                                                   20


<210>  13783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13783
agugcugcuu uaauaaucau                                                   20


<210>  13784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13784
uccaagacac cuucccagac                                                   20


<210>  13785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13785
uggaagacga ggauuuugcc                                                   20


<210>  13786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13786
gggaaggugu cuuggaagac                                                   20


<210>  13787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13787
gcagcauucu cucccuacuc                                                   20


<210>  13788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13788
ccagaaggag agccacccag                                                   20


<210>  13789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13789
ugauuuaaca uaagcaccac                                                   20


<210>  13790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13790
uccaccacau cucaugacaa                                                   20


<210>  13791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13791
ugagaugugg uggaggacac                                                   20


<210>  13792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13792
cacuggcuac aacaaaaaau                                                   20


<210>  13793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13793
uuggcccgac acuccaggcc                                                   20


<210>  13794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13794
ggccaaggac uuuagauuuu                                                   20


<210>  13795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13795
ucucucuuuc uggggaugca                                                   20


<210>  13796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13796
gacuggccga gucccugucc                                                   20


<210>  13797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13797
gacugcaucc ccagaaagag                                                   20


<210>  13798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13798
cuguccacca ccuccaccuu                                                   20


<210>  13799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13799
accaccucca ccuuuugcuc                                                   20


<210>  13800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13800
uacucuguca ccaggcugga                                                   20


<210>  13801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13801
ccaggcugga gugcaguggc                                                   20


<210>  13802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13802
cagcuacuug ggaggcugag                                                   20


<210>  13803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13803
cuacuaaaaa aauacaaaaa                                                   20


<210>  13804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13804
agagauugag aucauccugg                                                   20


<210>  13805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13805
ugguccccag ccaauacaua                                                   20


<210>  13806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13806
ccagccaaua cauaaggauc                                                   20


<210>  13807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13807
cuucaacugg aucgcaaauu                                                   20


<210>  13808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13808
aacuugcuuc uuuuccuuuc                                                   20


<210>  13809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13809
acauuaaacu uuuggggcaa                                                   20


<210>  13810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13810
gauagauaua acuacuaaau                                                   20


<210>  13811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13811
uuucauucau uuuucuugcu                                                   20


<210>  13812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13812
cuucucucua auuuuagaug                                                   20


<210>  13813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13813
acuaaaaauc cuggucacuu                                                   20


<210>  13814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13814
aaaucuauuu aaaugacuuu                                                   20


<210>  13815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13815
uuuaaauaga uuuugacuau                                                   20


<210>  13816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13816
auuuaaauau uacacuaagg                                                   20


<210>  13817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13817
agcugcuaaa augaauaggc                                                   20


<210>  13818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13818
cugccuauuc auuuuagcag                                                   20


<210>  13819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13819
uuuuuuaauu ccaguuggcc                                                   20


<210>  13820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13820
uggucauuuu uuaauuccag                                                   20


<210>  13821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13821
aauuaauuuu uuaguccugg                                                   20


<210>  13822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13822
uauugaaauu ggagauauau                                                   20


<210>  13823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13823
acaacuggaa acugcugcug                                                   20


<210>  13824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13824
aggcugcagc uguuuaugag                                                   20


<210>  13825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13825
gugggaauac auguuuuucc                                                   20


<210>  13826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13826
uacagauggg ccuaacgcug                                                   20


<210>  13827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13827
guguauuucc uguaaaaugu                                                   20


<210>  13828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13828
uauccuggcc uugugcaggu                                                   20


<210>  13829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13829
aaccagucau auccuggccu                                                   20


<210>  13830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13830
uccggguaac ucugcccccc                                                   20


<210>  13831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13831
cuaacugggu ggggggcaga                                                   20


<210>  13832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13832
auaagggguc acuaacuggg                                                   20


<210>  13833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13833
uccugccucu gcuggccaua                                                   20


<210>  13834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13834
gauacugugu ggucuuccug                                                   20


<210>  13835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13835
uuuaauggau gagcaacuca                                                   20


<210>  13836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13836
ucccugcucc cccuauauug                                                   20


<210>  13837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13837
acacaucaua gcugaagccu                                                   20


<210>  13838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13838
cauuuuaugg gaaauuggau                                                   20


<210>  13839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13839
gugcaggaaa uguaaaccaa                                                   20


<210>  13840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13840
ccccugcugg gucugugcag                                                   20


<210>  13841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13841
uuccugucgc cccugcuggg                                                   20


<210>  13842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13842
gugagaguau ucuggcuaaa                                                   20


<210>  13843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13843
uggagcaugg ggcacuagca                                                   20


<210>  13844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13844
uuaaaaauaa ccaaauuuuc                                                   20


<210>  13845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13845
uaaguccacu gcaccugaca                                                   20


<210>  13846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13846
acugcaccug acagaguauu                                                   20


<210>  13847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13847
ggugcagugg acuuaagacc                                                   20


<210>  13848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13848
agagaaacca gccuucuagg                                                   20


<210>  13849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13849
ccuuuauguu uucagucaug                                                   20


<210>  13850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13850
ugcaguuuca agccccaaaa                                                   20


<210>  13851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13851
uuuauuuuuc uucugaagaa                                                   20


<210>  13852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13852
caaccagggg auaguaaagg                                                   20


<210>  13853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13853
uccacguaua uucacuaacu                                                   20


<210>  13854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13854
cuccugcagu cuuguucaca                                                   20


<210>  13855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13855
uguucacacu guuaauuugc                                                   20


<210>  13856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13856
uugaggaaag gguuugcuca                                                   20


<210>  13857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13857
ucccuacuaa aggcauuaga                                                   20


<210>  13858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13858
acuucaguca ucccuacuaa                                                   20


<210>  13859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13859
gacaaauaau cuguguuagc                                                   20


<210>  13860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13860
gacagugaau cuuaacaucc                                                   20


<210>  13861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13861
uccccuacuu ugauaagcau                                                   20


<210>  13862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13862
uuuuccauaa cugcugaguc                                                   20


<210>  13863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13863
cugcuagaaa augguuaaag                                                   20


<210>  13864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13864
ugaacuuuuc caucaaacug                                                   20


<210>  13865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13865
cuaggagaga aaacuuuuug                                                   20


<210>  13866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13866
augaaggugu cagagcaaga                                                   20


<210>  13867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13867
gagcaagaca caaaauccuc                                                   20


<210>  13868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13868
ugcucugaca ccuucauuga                                                   20


<210>  13869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13869
cuugaggauu uugugucuug                                                   20


<210>  13870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13870
ggaggccagg gaggaccugg                                                   20


<210>  13871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13871
ucccuggccu ccugacuucc                                                   20


<210>  13872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13872
aucuucugaa guuucuggcu                                                   20


<210>  13873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13873
accuucuuga aacaaaacag                                                   20


<210>  13874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13874
acagauuuac uuauuagagu                                                   20


<210>  13875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13875
aauguaguuu uuguuugaac                                                   20


<210>  13876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13876
uucuucucca gcguccuggu                                                   20


<210>  13877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13877
ugguaaagga gacaacaaaa                                                   20


<210>  13878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13878
ccuuuaccag gacgcuggag                                                   20


<210>  13879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13879
accuuuuggc uguuuuguug                                                   20


<210>  13880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13880
gucuaccuuu uggcuguuuu                                                   20


<210>  13881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13881
ugacuaauug aaaguagacc                                                   20


<210>  13882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13882
ggacuagagg auuucccagc                                                   20


<210>  13883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13883
acuuucaauu agucaggacu                                                   20


<210>  13884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13884
uuacacuuua aaauaggugg                                                   20


<210>  13885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13885
cuugagccca cuacacucau                                                   20


<210>  13886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13886
cuugaaaaac uuuccuuaau                                                   20


<210>  13887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13887
agugguauug agaaaaugca                                                   20


<210>  13888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13888
uauucucaau uucuuuuuuu                                                   20


<210>  13889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13889
uaagagaaua ucacuuccca                                                   20


<210>  13890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13890
agaaagaagc ugccuuuggc                                                   20


<210>  13891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13891
cccuucaggg cuugguuuug                                                   20


<210>  13892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13892
gcagcagcug ugcuucgagu                                                   20


<210>  13893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13893
uucaguaagu gaauuuguug                                                   20


<210>  13894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13894
ccggcagccc ucucugcaua                                                   20


<210>  13895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13895
cucuacauga gagggagagg                                                   20


<210>  13896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13896
aauucauuca ucccucuccc                                                   20


<210>  13897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13897
gagagucauu uuggaggcuc                                                   20


<210>  13898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13898
uuuuggaggc ucagccguug                                                   20


<210>  13899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13899
guuugugcug ggauccggcc                                                   20


<210>  13900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13900
uggucaguuu gugcugggau                                                   20


<210>  13901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13901
cuccuaccau uuagagaggg                                                   20


<210>  13902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13902
uuuaggcuac cauuacggca                                                   20


<210>  13903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13903
guuugccgua augguagccu                                                   20


<210>  13904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13904
gaacucugaa gucaguuugc                                                   20


<210>  13905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13905
cgccagccau ucuuuuggua                                                   20


<210>  13906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13906
uucccuuugg ugccccuccu                                                   20


<210>  13907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13907
ggugaaaagc uaggcucccg                                                   20


<210>  13908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13908
uggaaaguug uauagggccu                                                   20


<210>  13909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13909
uaauaaggcc cuauacaacu                                                   20


<210>  13910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13910
ggccagcccu acuagaaccg                                                   20


<210>  13911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13911
ccuucccuug cauacuuccu                                                   20


<210>  13912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13912
agagggaagg aaguaugcaa                                                   20


<210>  13913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13913
ucaggauggg ggugggggag                                                   20


<210>  13914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13914
cuuuuaucac caaagcccuu                                                   20


<210>  13915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13915
ggaaagggcu uuggugauaa                                                   20


<210>  13916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13916
agcacaaugu uucacacugu                                                   20


<210>  13917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13917
caugauucgg cuacccaagg                                                   20


<210>  13918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13918
auaaagagcc agcagagaca                                                   20


<210>  13919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13919
cugcuggcuc uuuauggaca                                                   20


<210>  13920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13920
ugcccuuuaa auauuagauu                                                   20


<210>  13921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13921
augugagcua auagcaggga                                                   20


<210>  13922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13922
ugaaguucaa uggagaaaac                                                   20


<210>  13923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13923
cucauucuac cccuuuguuu                                                   20


<210>  13924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13924
uaagcauguu ucauuaaaua                                                   20


<210>  13925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13925
uuguaauuac aagcucauau                                                   20


<210>  13926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13926
cagcuuucau uuguacacuc                                                   20


<210>  13927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13927
guaauauagc acuuagugag                                                   20


<210>  13928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13928
ucuuuaaugu caguaauaua                                                   20


<210>  13929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13929
uuuuuuguuu uuguuuuuuu                                                   20


<210>  13930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13930
uuugcaacau acuuacuugc                                                   20


<210>  13931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13931
uaacaccacc acaagaccuc                                                   20


<210>  13932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13932
ugugguggug uuaggacucu                                                   20


<210>  13933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13933
ucacuauucc auaaguugag                                                   20


<210>  13934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13934
acuguugagc aaauauccug                                                   20


<210>  13935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13935
uucaggaacc aggauauuug                                                   20


<210>  13936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13936
uauugcaaug ggcauauaug                                                   20


<210>  13937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13937
auggcugugu aucauaauuu                                                   20


<210>  13938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13938
uccuaauggc uacaugaagg                                                   20


<210>  13939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13939
uuguccuccu aauggcuaca                                                   20


<210>  13940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13940
uuuugcauuu uuccauguua                                                   20


<210>  13941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13941
uacuauuucc aguuucuuuu                                                   20


<210>  13942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13942
uuaugaugca aaagaaaugg                                                   20


<210>  13943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13943
ccacaugaaa caucuuaauu                                                   20


<210>  13944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13944
auggaaagcu accugggaug                                                   20


<210>  13945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13945
aagcugcaag uuguuuuagu                                                   20


<210>  13946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13946
ucuguucuca uucuucuuaa                                                   20


<210>  13947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13947
ugcgucuucu guucucauuc                                                   20


<210>  13948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13948
cacagaaaag aguguaccua                                                   20


<210>  13949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13949
uaaaaaauua uuagcauuua                                                   20


<210>  13950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13950
ccuccuagga auuggcuuuu                                                   20


<210>  13951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13951
ucaaaagugu uaugguaaaa                                                   20


<210>  13952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13952
gugagucuac uccuaagacu                                                   20


<210>  13953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13953
uaggaguaga cucacagacc                                                   20


<210>  13954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13954
uguacucagg uugcauauaa                                                   20


<210>  13955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13955
ggcuuccaag cugaauauga                                                   20


<210>  13956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13956
uauuuuaaaa uaugugcaau                                                   20


<210>  13957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13957
gcaaaagagu cauauuuuaa                                                   20


<210>  13958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13958
ucgucagcac cugaaucaug                                                   20


<210>  13959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13959
gcaccugaau cauggagaag                                                   20


<210>  13960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13960
aagggggaag uuacagagua                                                   20


<210>  13961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13961
gccugaaaca gcuuuuuaaa                                                   20


<210>  13962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13962
uacccuucgc uacagaaauc                                                   20


<210>  13963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13963
aggaagaggg uuauugcaga                                                   20


<210>  13964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13964
cagguggccc aagcacagca                                                   20


<210>  13965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13965
acgcaguugc ccaagacaca                                                   20


<210>  13966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13966
guucuugucu aguaugcaca                                                   20


<210>  13967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13967
aguaugcaca gacuccuuau                                                   20


<210>  13968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13968
gugcauacua gacaagaacu                                                   20


<210>  13969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13969
caaaacuacc auccuagcuc                                                   20


<210>  13970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13970
gcauuaacac uguguagaau                                                   20


<210>  13971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13971
gcuuagcaca gguccgcauu                                                   20


<210>  13972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13972
ugaaaugccu ccuaaagccu                                                   20


<210>  13973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13973
gaaaaguuuu ucucauucua                                                   20


<210>  13974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13974
ucggucucag ccaaggcgcc                                                   20


<210>  13975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13975
cagccaaggc gccuacuucg                                                   20


<210>  13976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13976
cccaccuaga agcucacagu                                                   20


<210>  13977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13977
gaguaaugca cccuaguugu                                                   20


<210>  13978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13978
ccccugguug ccccucaggg                                                   20


<210>  13979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13979
agaaagagca ccaaguuucc                                                   20


<210>  13980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13980
aaacccauag cugaaggccc                                                   20


<210>  13981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13981
augcacacac acacacacac                                                   20


<210>  13982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13982
uccaacuuuu ccuuagguuu                                                   20


<210>  13983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13983
ccaccccucu cuagaugggg                                                   20


<210>  13984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13984
guuuuguugc uuguuauugg                                                   20


<210>  13985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13985
uucccuaaca ugauugauga                                                   20


<210>  13986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13986
agcaauuaau gaguaaaaau                                                   20


<210>  13987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13987
uguuuguggc auuuaucagu                                                   20


<210>  13988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13988
aaugcuaaag ugcacguuac                                                   20


<210>  13989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13989
ucaaauaaac aucuuccugg                                                   20


<210>  13990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13990
ucaauuuaaa gcaaauauau                                                   20


<210>  13991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13991
uauauuuaca aacauucugc                                                   20


<210>  13992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13992
ugaacagccc cguuagggag                                                   20


<210>  13993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13993
cccuaacggg gcuguucaag                                                   20


<210>  13994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13994
gaccuugaca ccuuaaauua                                                   20


<210>  13995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13995
gacucuuuuc auuuggggca                                                   20


<210>  13996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13996
aggucugacu cuuuucauuu                                                   20


<210>  13997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13997
guguuuagag cuaccucuuu                                                   20


<210>  13998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13998
aaguacaaca auaaucugua                                                   20


<210>  13999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  13999
gcuucggcua cucgcuuauu                                                   20


<210>  14000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14000
ggggucagcu ucggcuacuc                                                   20


<210>  14001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14001
uccucacuuc cccaccucuc                                                   20


<210>  14002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14002
ccaccccagu guugacacag                                                   20


<210>  14003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14003
acacuggggu ggugacaucc                                                   20


<210>  14004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14004
ccacaacuuc cuagaauguu                                                   20


<210>  14005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14005
uauuggcgau uguaauugug                                                   20


<210>  14006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14006
uuucuuauug ucuuauuggc                                                   20


<210>  14007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14007
aguagaacuc aacaaccugg                                                   20


<210>  14008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14008
ugcugcuagg uuggucaguu                                                   20


<210>  14009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14009
auccauucua gaauaugaga                                                   20


<210>  14010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14010
cuucauccuu acaauuaccc                                                   20


<210>  14011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14011
aguguuuuca uggauugggc                                                   20


<210>  14012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14012
uggaggucca guguuuucau                                                   20


<210>  14013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14013
caaaauuaau cagugaugga                                                   20


<210>  14014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14014
gcuuggcuga acuguaagga                                                   20


<210>  14015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14015
gaguuuucug ucugcuuggc                                                   20


<210>  14016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14016
ucagucugag uuuucugucu                                                   20


<210>  14017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14017
gucuucaguc ugaguuuucu                                                   20


<210>  14018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14018
gcuccugauc agaaggcaag                                                   20


<210>  14019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14019
gggccuccuu cuaggagcaa                                                   20


<210>  14020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14020
uugcuccuag aaggaggccc                                                   20


<210>  14021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14021
auacauuuca aaaacaaaac                                                   20


<210>  14022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14022
auuauuguuu uguuuuugaa                                                   20


<210>  14023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14023
ccacuauguc cuuucaacug                                                   20


<210>  14024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14024
uuucaacugu uuucugguuc                                                   20


<210>  14025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14025
aguucaaaga gaaggcuggg                                                   20


<210>  14026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14026
agauuucccc agccuucucu                                                   20


<210>  14027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14027
aggucuagau uuccccagcc                                                   20


<210>  14028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14028
cuugcauuug guaauaauau                                                   20


<210>  14029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14029
gauuagcagu gggaaugugc                                                   20


<210>  14030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14030
uuuugugauu caccaugucu                                                   20


<210>  14031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14031
cucagaguuu uaaccagugg                                                   20


<210>  14032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14032
acuugugcaa uccaaguauu                                                   20


<210>  14033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14033
gugguguuuu aguaaaaaaa                                                   20


<210>  14034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14034
gagccaugau ucagguacgg                                                   20


<210>  14035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14035
ugaaucagau gcccguaccu                                                   20


<210>  14036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14036
gcaguuagga gcagaguccu                                                   20


<210>  14037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14037
caccauguug cccaggcugg                                                   20


<210>  14038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14038
caaacuccug accucaagag                                                   20


<210>  14039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14039
ggaguuugag accagccugg                                                   20


<210>  14040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14040
cuuuaugagc caaaagaaua                                                   20


<210>  14041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14041
agaaccauua ucaguaaaua                                                   20


<210>  14042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14042
uucugcaaag uucaggcuuu                                                   20


<210>  14043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14043
aguggauuaa aagccugaac                                                   20


<210>  14044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14044
aggcuagagu cuaguggauu                                                   20


<210>  14045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14045
acuacaaaga uugaaaggag                                                   20


<210>  14046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14046
cauauguuau gugcuugaac                                                   20


<210>  14047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14047
uucccaagac cuacacgcug                                                   20


<210>  14048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14048
ugggaaggac cuagagauga                                                   20


<210>  14049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14049
caauccagag guuuggaaau                                                   20


<210>  14050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14050
gaacguggag ucacagaagg                                                   20


<210>  14051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14051
cagaaggcgu cugugaaacc                                                   20


<210>  14052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14052
gugaaaccca aagcccuugg                                                   20


<210>  14053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14053
aagggcuuug gguuucacag                                                   20


<210>  14054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14054
cagcguugcc uguccaaggg                                                   20


<210>  14055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14055
uuaauguaaa cccuccugug                                                   20


<210>  14056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14056
gagcacagga ggguuuacau                                                   20


<210>  14057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14057
uacccccuuc agacacaggg                                                   20


<210>  14058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14058
gaagggggua agacagccca                                                   20


<210>  14059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14059
gcccuccaca ggguccugca                                                   20


<210>  14060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14060
ugcaggaggu cuuguuucug                                                   20


<210>  14061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14061
uguuucugag ucaggggggc                                                   20


<210>  14062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14062
ggggggccuc uguuuaacca                                                   20


<210>  14063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14063
gcucugguua aacagaggcc                                                   20


<210>  14064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14064
acuuugcccc gcagaguugg                                                   20


<210>  14065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14065
accuacgugu aauuaugcug                                                   20


<210>  14066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14066
ugagugauuu auugaagaac                                                   20


<210>  14067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14067
cugauaauuc ucuucuuuuu                                                   20


<210>  14068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14068
ggccuaagga gaacaaccag                                                   20


<210>  14069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14069
cugguuguuc uccuuaggcc                                                   20


<210>  14070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14070
guguuuugag gccuuuccgu                                                   20


<210>  14071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14071
cugaaaaagc aaaaugucag                                                   20


<210>  14072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14072
uuaugcagcc acaucagauc                                                   20


<210>  14073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14073
agauggauuu uugggaucug                                                   20


<210>  14074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14074
gggggagaga gcucuccucu                                                   20


<210>  14075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14075
gguauguuac uauucuuuua                                                   20


<210>  14076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14076
ccucccaaag uaaaagaaua                                                   20


<210>  14077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14077
aucagguacu cgguucugcc                                                   20


<210>  14078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14078
ccugguagga agcagagaga                                                   20


<210>  14079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14079
ucuccuucuu gauaggaaag                                                   20


<210>  14080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14080
ucugcguggc accaccuggc                                                   20


<210>  14081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14081
gaaaaagaac acagaauugg                                                   20


<210>  14082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14082
aguucaguuc augagcccuu                                                   20


<210>  14083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14083
guucucauca gcucuguuca                                                   20


<210>  14084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14084
aaaugauuuu guuacuuaac                                                   20


<210>  14085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14085
gaggagccag guucuuucac                                                   20


<210>  14086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14086
ucauuauuac uguggccagu                                                   20


<210>  14087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14087
ggaucugaca uuguaaaauc                                                   20


<210>  14088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14088
gauccugacu uauuucacag                                                   20


<210>  14089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14089
ggaauuugcc acuaggagcu                                                   20


<210>  14090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14090
auuuuuugcc uuuauauacu                                                   20


<210>  14091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14091
ggcauuuggc cccagagggg                                                   20


<210>  14092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14092
cagugcugag cccagcucua                                                   20


<210>  14093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14093
acaggcuggg acuuugcuga                                                   20


<210>  14094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14094
cagccuguug accuuugggu                                                   20


<210>  14095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14095
ccucucuagc cucaguuucc                                                   20


<210>  14096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14096
acuucaccag caccagccac                                                   20


<210>  14097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14097
uuacaagggc cuucccugaa                                                   20


<210>  14098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14098
aaggauuuag uuggcuucag                                                   20


<210>  14099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14099
ucucugucca aggauuuagu                                                   20


<210>  14100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14100
ugcagaaucu ucaugugauc                                                   20


<210>  14101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14101
ugcagucuug cagaaucuuc                                                   20


<210>  14102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14102
ccaaaaaaaa aaaaaaaaga                                                   20


<210>  14103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14103
ucuggaaaaa uguuguggcu                                                   20


<210>  14104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14104
auuugucuuc uggaaaaaug                                                   20


<210>  14105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14105
caggaucaau augagguuag                                                   20


<210>  14106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14106
ugccggcugc ccuauuuuca                                                   20


<210>  14107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14107
aaauuuagua uuuuucaugc                                                   20


<210>  14108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14108
uuugcaugag caugaaaaau                                                   20


<210>  14109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14109
cccucucccu cucucaccuu                                                   20


<210>  14110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14110
cgcccuggug gagcauucua                                                   20


<210>  14111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14111
gauguuuaca gagaaaaggc                                                   20


<210>  14112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14112
ccaaagagug uccuucuuuu                                                   20


<210>  14113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14113
uucuuuugau uuuuuuucaa                                                   20


<210>  14114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14114
uaaaauuuca uauaaauggu                                                   20


<210>  14115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14115
uuuuuaauuu uuaauuuuua                                                   20


<210>  14116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14116
cacagauuuu uuuccaugau                                                   20


<210>  14117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14117
cacuguuugu cccacagauu                                                   20


<210>  14118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14118
gugggagccc aggaaaggcc                                                   20


<210>  14119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14119
ugcccaaacg caaagcagca                                                   20


<210>  14120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14120
aaacauaucu caguuucugg                                                   20


<210>  14121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14121
caaaagccaa aaucagggua                                                   20


<210>  14122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14122
agguugcugg cugaauucgg                                                   20


<210>  14123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14123
ucuagccaca agaaaccgaa                                                   20


<210>  14124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14124
uuuccuugug gcuggcaguc                                                   20


<210>  14125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14125
ugagggaaag gugggaaucu                                                   20


<210>  14126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14126
ugagauuccc accuuucccu                                                   20


<210>  14127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14127
acugcuccuu gucgugagau                                                   20


<210>  14128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14128
cugucaacug cuccuugucg                                                   20


<210>  14129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14129
cuaugugcua aaagcaaacc                                                   20


<210>  14130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14130
cucauuuugc accucaguaa                                                   20


<210>  14131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14131
gggccuccug guuucuugug                                                   20


<210>  14132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14132
agcaggaguu gagagccucu                                                   20


<210>  14133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14133
ugcacaggaa accccccagc                                                   20


<210>  14134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14134
cauaggugcc ggauugaugg                                                   20


<210>  14135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14135
uugcucagag aaagccugau                                                   20


<210>  14136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14136
ggcuuauuug gcuuuauggg                                                   20


<210>  14137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14137
cagggucagg cuuauuuggc                                                   20


<210>  14138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14138
ggccuagcug ggagguacag                                                   20


<210>  14139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14139
uauuuuuauu cauuuuucca                                                   20


<210>  14140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14140
uuuaagcuuu uccacaugug                                                   20


<210>  14141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14141
guuuuuguac uugugucuuu                                                   20


<210>  14142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14142
gucuguuuuu guacuugugu                                                   20


<210>  14143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14143
agaaccaaaa cccuaagaau                                                   20


<210>  14144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14144
auaaaguugg gcuuuuucca                                                   20


<210>  14145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14145
ggccucagca acgggcagug                                                   20


<210>  14146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14146
agggccuggg agcagaggcc                                                   20


<210>  14147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14147
cuccuaagaa uccaggaucc                                                   20


<210>  14148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14148
ggauccugga uucuuaggag                                                   20


<210>  14149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14149
uuauuucccu uccugaugug                                                   20


<210>  14150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14150
ccaucguaaa uaaauaaagu                                                   20


<210>  14151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14151
auauucuuug agggcccaaa                                                   20


<210>  14152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14152
gcuguuuaac agagcagauu                                                   20


<210>  14153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14153
guuuccccua aagugcacga                                                   20


<210>  14154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14154
aggaaggccu uucugagggc                                                   20


<210>  14155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14155
gcccucagaa aggccuuccu                                                   20


<210>  14156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14156
uucaguuucc agcuugaaug                                                   20


<210>  14157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14157
ucuccauggu gccugccuca                                                   20


<210>  14158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14158
agagaccacc acaggcaaag                                                   20


<210>  14159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14159
cuggacccuu cagucuucuc                                                   20


<210>  14160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14160
uugccugugg uggucucugg                                                   20


<210>  14161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14161
cuuggucuuu gccuguggug                                                   20


<210>  14162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14162
ccaggccugg caggccacac                                                   20


<210>  14163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14163
aagugcaaug agcaaacuaa                                                   20


<210>  14164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14164
uggccuccca uaguguuagg                                                   20


<210>  14165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14165
cgaacuccug agcucaggca                                                   20


<210>  14166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14166
cagcuaccca ggaggcugag                                                   20


<210>  14167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14167
ggaguacagu ggcucaaucu                                                   20


<210>  14168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14168
cucagucugg aguacagugg                                                   20


<210>  14169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14169
uguuguguca cucagucugg                                                   20


<210>  14170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14170
uggucuucau uuccaucagu                                                   20


<210>  14171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14171
ucauuuccau cagugauuga                                                   20


<210>  14172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14172
aucacugaug gaaaugaaga                                                   20


<210>  14173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14173
gccagagcaa cauucucagc                                                   20


<210>  14174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14174
guguuucuca cauucucuuu                                                   20


<210>  14175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14175
acauucaugg ugcuccagaa                                                   20


<210>  14176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14176
caccggaagg ccacacucau                                                   20


<210>  14177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14177
ugagcgagca ggggccucug                                                   20


<210>  14178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14178
gguuggccug gcagaaggcu                                                   20


<210>  14179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14179
uauugccucu aaaucaagug                                                   20


<210>  14180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14180
ugcuucauca cuugauuuag                                                   20


<210>  14181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14181
ggacacuuuu uuaaacgauu                                                   20


<210>  14182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14182
ugacaguugu caugcuucau                                                   20


<210>  14183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14183
ugagguuugu gaacacauuc                                                   20


<210>  14184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14184
cugaggacca ggaucuuuga                                                   20


<210>  14185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14185
ucagggacac uugagauggg                                                   20


<210>  14186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14186
aagauccugg uccucaggga                                                   20


<210>  14187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14187
cugugagaau cggccaccug                                                   20


<210>  14188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14188
ccugaaaguu gacauaaugc                                                   20


<210>  14189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14189
acuuucaggg gaccuggggc                                                   20


<210>  14190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14190
aggcauuaug ucaacuuuca                                                   20


<210>  14191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14191
gugaagagag cuggagcaga                                                   20


<210>  14192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14192
cuuauucccu ucuuuuuuau                                                   20


<210>  14193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14193
uuuauuugag cuuuaggcca                                                   20


<210>  14194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14194
gcccagcaug ccugcuggau                                                   20


<210>  14195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14195
gacuuaacau uuggggaugc                                                   20


<210>  14196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14196
gacauuuucu uagcugaugg                                                   20


<210>  14197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14197
ucauuaacag aaaaauauuu                                                   20


<210>  14198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14198
gccuuaccug cuucuguacu                                                   20


<210>  14199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14199
uucuuccuga caccuuguug                                                   20


<210>  14200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14200
ggaagaaaga cauugcuuuc                                                   20


<210>  14201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14201
ccagcaugca cacaggaagc                                                   20


<210>  14202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14202
uuuuccccac aagccaagag                                                   20


<210>  14203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14203
ucugcucccc acacuuaaau                                                   20


<210>  14204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14204
ggaguucgag accagccugg                                                   20


<210>  14205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14205
cgaacuccug accucaggug                                                   20


<210>  14206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14206
uguguaaacc aagguuuuuc                                                   20


<210>  14207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14207
gucuccaauu agaccagcag                                                   20


<210>  14208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14208
ccaauuagac cagcaguucu                                                   20


<210>  14209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14209
aauuggagac agacacaaag                                                   20


<210>  14210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14210
acagugcaga gguuaagaac                                                   20


<210>  14211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14211
ccgggaaccc ugagggacaa                                                   20


<210>  14212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14212
cucaggguuc ccggggacua                                                   20


<210>  14213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14213
gguuuaaaaa auacauuauu                                                   20


<210>  14214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14214
aauaaucacc uacuucuugc                                                   20


<210>  14215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14215
gauugggucu aauaaucacc                                                   20


<210>  14216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14216
gccuguuugg ugauggaaga                                                   20


<210>  14217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14217
ucagccuguu uggugaugga                                                   20


<210>  14218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14218
aagggcagcc ccugccuacu                                                   20


<210>  14219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14219
ccagcuucua gcacggugcu                                                   20


<210>  14220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14220
auggcuaagu ccggccuauc                                                   20


<210>  14221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14221
ggccuaucag gacuggggcc                                                   20


<210>  14222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14222
ugauaggccg gacuuagcca                                                   20


<210>  14223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14223
gcgcaagccc cccaggcccc                                                   20


<210>  14224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14224
gucuggcugg acggcacagu                                                   20


<210>  14225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14225
ggcuggacgg cacagucgga                                                   20


<210>  14226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14226
agccagacug acaucugugg                                                   20


<210>  14227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14227
gacaccuccg aaaggcuguc                                                   20


<210>  14228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14228
gacugugccg uccagccaga                                                   20


<210>  14229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14229
acucccuguc ugagaauaaa                                                   20


<210>  14230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14230
gagaauaaac aggaccacaa                                                   20


<210>  14231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14231
uguuuauucu cagacaggga                                                   20


<210>  14232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14232
uacaaaaaaa aaaaauccaa                                                   20


<210>  14233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14233
cucucucuca cacacacaca                                                   20


<210>  14234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14234
gcagaggcuc agcccugccc                                                   20


<210>  14235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14235
gugggcugag ggauuggugu                                                   20


<210>  14236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14236
ugggaaaguc ugugggcuga                                                   20


<210>  14237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14237
gccucuuccu cccccacacc                                                   20


<210>  14238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14238
cccuucauca uaauuaagau                                                   20


<210>  14239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14239
agugugugca ucuguaauuu                                                   20


<210>  14240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14240
uuaccauuuc ugcuucuccc                                                   20


<210>  14241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14241
acucaaagcu gaccuuuaac                                                   20


<210>  14242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14242
gcuuugaguu gacucucaau                                                   20


<210>  14243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14243
aucuucugau gaaaaggcug                                                   20


<210>  14244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14244
agaagcucag cucagccagc                                                   20


<210>  14245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14245
agucugcuuc cagaauccag                                                   20


<210>  14246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14246
gcuuccagaa uccaggacac                                                   20


<210>  14247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14247
uggauucugg aagcagacug                                                   20


<210>  14248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14248
aauucaaaug ccaaguucuu                                                   20


<210>  14249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14249
auuucuucau guguaaaaca                                                   20


<210>  14250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14250
gaggaguuag uacugauucu                                                   20


<210>  14251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14251
ugcaaaccuc cuaagaaugu                                                   20


<210>  14252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14252
ugaaacuugu ugggacaggu                                                   20


<210>  14253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14253
gggggagcau ugaacccuug                                                   20


<210>  14254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14254
gcucaugcua cuucacaagu                                                   20


<210>  14255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14255
cuuucagugu gggagauguc                                                   20


<210>  14256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14256
aagcagguca uuaagcaggu                                                   20


<210>  14257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14257
uuaagcaggu aaaauugacc                                                   20


<210>  14258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14258
auuuuaccug cuuaaugacc                                                   20


<210>  14259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14259
aaacagggug ucgagcauuc                                                   20


<210>  14260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14260
cugucaccau aguccucgaa                                                   20


<210>  14261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14261
ccagagcuug augaucuucg                                                   20


<210>  14262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14262
gcagucagcc cauauucccc                                                   20


<210>  14263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14263
gcccauauuc cccuguuccu                                                   20


<210>  14264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14264
gaugcauuug aaauggcuuc                                                   20


<210>  14265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14265
ucuccugaaa ccucaaaggu                                                   20


<210>  14266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14266
ggucaucucc ugaaaccuca                                                   20


<210>  14267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14267
gcagcccagg gucgggucau                                                   20


<210>  14268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14268
uugaagguga gccucggguc                                                   20


<210>  14269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14269
uauuucgugc cuguguccuu                                                   20


<210>  14270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14270
auccccaagg ccucagacag                                                   20


<210>  14271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14271
gaggccuugg ggauugacug                                                   20


<210>  14272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14272
uguggcuguc ugaggccuug                                                   20


<210>  14273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14273
gcaucccccu ccuggggucc                                                   20


<210>  14274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14274
ggccugucug caucccccuc                                                   20


<210>  14275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14275
uguucccccu ccugugccug                                                   20


<210>  14276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14276
acauuuuuuu uaauguggug                                                   20


<210>  14277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14277
aauuucauuc auuucuucug                                                   20


<210>  14278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14278
gagagucugg gugggaaggc                                                   20


<210>  14279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14279
gggugggaag gcaacucaga                                                   20


<210>  14280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14280
ucugaguugc cuucccaccc                                                   20


<210>  14281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14281
ccaagguaca gaaacccaga                                                   20


<210>  14282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14282
ggguuucugu accuugggga                                                   20


<210>  14283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14283
cccccccccc cccacccaca                                                   20


<210>  14284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14284
gucccccccc cccccccacc                                                   20


<210>  14285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14285
aacagcacgu ccgucccccc                                                   20


<210>  14286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14286
ugugauauua aacauggucu                                                   20


<210>  14287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14287
cggaacugcg aacacugacc                                                   20


<210>  14288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14288
guguucgcag uuccgagacc                                                   20


<210>  14289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14289
ugguuagagg aagguauuuu                                                   20


<210>  14290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14290
gaguaacaca aaauacuagg                                                   20


<210>  14291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14291
uaguauuuug uguuacucug                                                   20


<210>  14292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14292
agugguccua guauuuugug                                                   20


<210>  14293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14293
guguuauguc uagugguccu                                                   20


<210>  14294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14294
ccaaccccca ccuccaaccc                                                   20


<210>  14295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14295
caaauguaag agaauuuuca                                                   20


<210>  14296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14296
uuguauuuua uuuuuccuuu                                                   20


<210>  14297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14297
gagugagaaa agcuguugug                                                   20


<210>  14298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14298
ugcgucugag ugagaaaagc                                                   20


<210>  14299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14299
uuugguggcu agaaugcugg                                                   20


<210>  14300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14300
guugucauuu gguggcuaga                                                   20


<210>  14301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14301
ucacuacccc cuuauauuuu                                                   20


<210>  14302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14302
agaguaauua aacuugcuau                                                   20


<210>  14303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14303
auuaugcaag auugugugug                                                   20


<210>  14304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14304
gggugaaucc ugcuggcucc                                                   20


<210>  14305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14305
ccuagcaugu cugggugaau                                                   20


<210>  14306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14306
auacggugcu cccugucucc                                                   20


<210>  14307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14307
gagauuccug aggccccacc                                                   20


<210>  14308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14308
aagggugucu gagauuccug                                                   20


<210>  14309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14309
uaccagacaa aaaucuuccu                                                   20


<210>  14310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14310
gguaugacuc cugggaacuu                                                   20


<210>  14311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14311
gcuuuuaaaa ggaaucauga                                                   20


<210>  14312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14312
gacaggggaa agugggcagg                                                   20


<210>  14313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14313
gacagguaga ggaagaaagc                                                   20


<210>  14314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14314
gucacaggua cacauugugu                                                   20


<210>  14315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14315
cagguacaca uuguguuucc                                                   20


<210>  14316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14316
acaagcagug ggggcauggc                                                   20


<210>  14317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14317
aauaacuguc aagugacuca                                                   20


<210>  14318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14318
agugacucaa cacuugacag                                                   20


<210>  14319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14319
cuugacaguu auuugacuca                                                   20


<210>  14320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14320
aguguugagu cacuugacag                                                   20


<210>  14321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14321
cuuccauacu ggcuccuggu                                                   20


<210>  14322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14322
ccaggagcca guauggaagg                                                   20


<210>  14323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14323
ucugugaugu gaggacuuga                                                   20


<210>  14324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14324
ucacaucaca gaggacaaaa                                                   20


<210>  14325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14325
ccauguggau uaauggccca                                                   20


<210>  14326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14326
agccgugcag uaagcuguag                                                   20


<210>  14327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14327
cucggauggu gucuagccgu                                                   20


<210>  14328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14328
uacccugucc cucggauggu                                                   20


<210>  14329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14329
cggucuuacc cugucccucg                                                   20


<210>  14330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14330
uggugaggcc acuugucacc                                                   20


<210>  14331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14331
ccagaaggcc cauuaugcua                                                   20


<210>  14332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14332
ugguccuaua acacaaauug                                                   20


<210>  14333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14333
uauaacacaa auugcaguau                                                   20


<210>  14334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14334
cuuucaucag aacaggaaaa                                                   20


<210>  14335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14335
gcaucuuuac aguaagccgu                                                   20


<210>  14336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14336
ccuuucuccc accuuucuug                                                   20


<210>  14337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14337
cauuuuuuau cuucuauagu                                                   20


<210>  14338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14338
auggcucugg uuugggcauu                                                   20


<210>  14339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14339
gagagaaugc ccaaaccaga                                                   20


<210>  14340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14340
acaaaaauuc accaacugua                                                   20


<210>  14341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14341
accauauaca accauaugac                                                   20


<210>  14342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14342
uaugguugua uaugguugac                                                   20


<210>  14343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14343
guguucuaca caucacugug                                                   20


<210>  14344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14344
ucuaucacua uuguuuugcc                                                   20


<210>  14345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14345
agaguuuugc auuuugcaau                                                   20


<210>  14346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14346
uugugguugg cuucuuucac                                                   20


<210>  14347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14347
uuguguggau guauguucuc                                                   20


<210>  14348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14348
uuagggaaau gcaaauuaaa                                                   20


<210>  14349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14349
guucaaaucu uucgcucauu                                                   20


<210>  14350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14350
auaguaagaa aucaaugcaa                                                   20


<210>  14351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14351
gucuugucuu uuuacuuuau                                                   20


<210>  14352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14352
ugucuuuuua cuuuauuaac                                                   20


<210>  14353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14353
uuuuacuuua uuaacagugu                                                   20


<210>  14354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14354
aaauucaguu aaucuuauau                                                   20


<210>  14355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14355
aucucuggac uuuguucuau                                                   20


<210>  14356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14356
agagauagac ccaugcauau                                                   20


<210>  14357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14357
gucuguacac uaacaccaca                                                   20


<210>  14358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14358
guacacuaac accacaaguu                                                   20


<210>  14359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14359
gauagcacug uauaaguccu                                                   20


<210>  14360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14360
uccaaaugug uuuuucuuuu                                                   20


<210>  14361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14361
auuucaacaa aaaaagccug                                                   20


<210>  14362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14362
augcaaaucc aaucaaaauc                                                   20


<210>  14363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14363
uccaggagcu uaaaacauaa                                                   20


<210>  14364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14364
caggcagacg ugaggaugau                                                   20


<210>  14365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14365
gccugugacu cuacaccauu                                                   20


<210>  14366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14366
uguauucugg caguggcaca                                                   20


<210>  14367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14367
ccacuuccuu gugccacugc                                                   20


<210>  14368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14368
cuguuucaca aucagggaaa                                                   20


<210>  14369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14369
uagaaaucuc aaguucuggg                                                   20


<210>  14370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14370
gggaucuggu gaacaaucgc                                                   20


<210>  14371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14371
gucugacuuu agcuuccuuc                                                   20


<210>  14372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14372
gacuuuagcu uccuucuaga                                                   20


<210>  14373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14373
gacagacaug aaaucaacuu                                                   20


<210>  14374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14374
cagagaucau cuaguccaca                                                   20


<210>  14375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14375
acauuuuaua gaugagcaaa                                                   20


<210>  14376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14376
uuccaguucu uguuuugcuc                                                   20


<210>  14377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14377
cagaguuaaa cagugaauug                                                   20


<210>  14378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14378
uagggugcua ccaauucacu                                                   20


<210>  14379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14379
ucuguccuca aggcuguuga                                                   20


<210>  14380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14380
ucaaggcugu ugaccuuuug                                                   20


<210>  14381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14381
acagccuuga ggacagaaga                                                   20


<210>  14382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14382
ucuccugucu gucaccagag                                                   20


<210>  14383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14383
gucaccagag ccauuuacgu                                                   20


<210>  14384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14384
ccagagccau uuacgucaca                                                   20


<210>  14385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14385
cagaacugga gcucuuagaa                                                   20


<210>  14386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14386
aucaguuggc ugugccagaa                                                   20


<210>  14387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14387
gaauuugguc uucaaguccc                                                   20


<210>  14388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14388
ucaagucccc ccgaugccuc                                                   20


<210>  14389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14389
ccccgaugcc uccuccuuuc                                                   20


<210>  14390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14390
uguguugaua gaugcacagg                                                   20


<210>  14391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14391
cuaagcuuuc uuaauaaugu                                                   20


<210>  14392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14392
gguuauagag gggauuuuga                                                   20


<210>  14393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14393
cugauuucug guuuauagcc                                                   20


<210>  14394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14394
uccaggaacc agaguugaau                                                   20


<210>  14395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14395
guuccaggcu cacugaguuu                                                   20


<210>  14396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14396
cuaaugggua gcugaaucuc                                                   20


<210>  14397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14397
uaaucuuccc accucccccc                                                   20


<210>  14398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14398
ugucuuugag ugaaagugcc                                                   20


<210>  14399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14399
uugagugaaa gugccacauu                                                   20


<210>  14400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14400
agagugaaug gggugggggc                                                   20


<210>  14401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14401
gggcaccgcc cccaccccau                                                   20


<210>  14402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14402
ccaaaauaug cccccauccu                                                   20


<210>  14403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14403
ugcccacagc guaggcacaa                                                   20


<210>  14404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14404
ucugugaggu gguccugccc                                                   20


<210>  14405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14405
acaaggaaau uccuugugga                                                   20


<210>  14406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14406
acaaggaauu uccuuguaga                                                   20


<210>  14407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14407
uuuguccaca aggaauuucc                                                   20


<210>  14408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14408
gauuagccuu ucccagggaa                                                   20


<210>  14409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14409
cuucuguacc uaugaccugg                                                   20


<210>  14410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14410
uagguacaga agagacaaau                                                   20


<210>  14411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14411
caccuuucca aaccaagcca                                                   20


<210>  14412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14412
aauggcauuu cuaguucuag                                                   20


<210>  14413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14413
uuauagcagc auguuuuaua                                                   20


<210>  14414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14414
uugcuauugu gaauagugcc                                                   20


<210>  14415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14415
aacaaugaua gacuggauua                                                   20


<210>  14416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14416
aucauuguug gacauuuggg                                                   20


<210>  14417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14417
augguaggca guuagcacau                                                   20


<210>  14418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14418
gagcugaggu uagaacaaaa                                                   20


<210>  14419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14419
uuaaacuuuu uuugaaaaca                                                   20


<210>  14420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14420
cuccucuagu gcucuagccu                                                   20


<210>  14421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14421
aguuagaaaa cgccuuuaag                                                   20


<210>  14422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14422
cccgaugcca guugccaaau                                                   20


<210>  14423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14423
ggaaggccga acaauguuuc                                                   20


<210>  14424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14424
uuuuacucau gguuguagga                                                   20


<210>  14425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14425
uuucuugaga cagcuuuucc                                                   20


<210>  14426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14426
caagaaagga ccauacacgu                                                   20


<210>  14427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14427
uccaauucug gaaaagcugu                                                   20


<210>  14428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14428
uuucuccucu uucugggugg                                                   20


<210>  14429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14429
augcauaaca aauuggggua                                                   20


<210>  14430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14430
acuucccuua caguucaggu                                                   20


<210>  14431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14431
aaaagauuuc uguauucugc                                                   20


<210>  14432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14432
gagaggcuaa cugcuguaac                                                   20


<210>  14433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14433
ugcaccagau gucccugaag                                                   20


<210>  14434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14434
agcuggucuu gcaccagaug                                                   20


<210>  14435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14435
aaacuagcuu cugggauagg                                                   20


<210>  14436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14436
cuuccuaucc cagaagcuag                                                   20


<210>  14437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14437
cuauuaagua aauacugaaa                                                   20


<210>  14438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14438
guuuuaaaac cagcaaagca                                                   20


<210>  14439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14439
augccgugug uuggaaagag                                                   20


<210>  14440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14440
auguuuaucu cuugaggccc                                                   20


<210>  14441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14441
ccaccagugg caaagcagag                                                   20


<210>  14442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14442
cagaagaacc ugguggcucc                                                   20


<210>  14443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14443
gguugguuuu cagagaacag                                                   20


<210>  14444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14444
uugcucggug ucagguuggu                                                   20


<210>  14445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14445
uaaaaguaga gauuuuaaaa                                                   20


<210>  14446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14446
ucuguguaga uguagguaau                                                   20


<210>  14447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14447
augaguaaua uuucauauuc                                                   20


<210>  14448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14448
agaaggagaa cugggagggg                                                   20


<210>  14449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14449
cuauuaaggc agaugaacgu                                                   20


<210>  14450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14450
aacucccacg uucaucugcc                                                   20


<210>  14451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14451
ccugcuuuga gguucaauua                                                   20


<210>  14452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14452
gggggcagug agaugcagag                                                   20


<210>  14453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14453
cagagcacag aaaagauuug                                                   20


<210>  14454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14454
ugagaggauc ucaagcuggg                                                   20


<210>  14455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14455
gcuggagagg cuuggcacca                                                   20


<210>  14456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14456
gauucuuccc cuuagagcac                                                   20


<210>  14457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14457
gaaagacuug acuuuaccau                                                   20


<210>  14458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14458
uucugacuca aaaauccaug                                                   20


<210>  14459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14459
agucuuucug acucaaaaau                                                   20


<210>  14460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14460
ucuagcuagu acaugguaaa                                                   20


<210>  14461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14461
uuaucuggaa aauggcaaua                                                   20


<210>  14462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14462
acucaguggg cacuuggcag                                                   20


<210>  14463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14463
auaaaugaau gucuacucag                                                   20


<210>  14464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14464
aaaccaguuu guauuccaga                                                   20


<210>  14465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14465
uauuuuucuu uuuaauagug                                                   20


<210>  14466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14466
uggaaugaac acuauuaaaa                                                   20


<210>  14467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14467
accacauuuu uguuauuuuc                                                   20


<210>  14468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14468
ugguuccuga aaacuuuuuc                                                   20


<210>  14469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14469
cacaacaaaa agacacaggu                                                   20


<210>  14470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14470
uuuuguugug ggacuugggu                                                   20


<210>  14471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14471
gcauguagau guguguugau                                                   20


<210>  14472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14472
ccugcugugg accuaguauu                                                   20


<210>  14473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14473
acagcaggug acucaacauu                                                   20


<210>  14474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14474
uuuuccuuga aacacuuggu                                                   20


<210>  14475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14475
ugcagguagu aagacauagu                                                   20


<210>  14476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14476
uacuaccugc aagacacagu                                                   20


<210>  14477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14477
gguguucaag accagccugg                                                   20


<210>  14478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14478
ugaacaccug accucagaug                                                   20


<210>  14479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14479
aaauccuguc ucuacuaaaa                                                   20


<210>  14480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14480
cuacuaaaaa auacaaaaau                                                   20


<210>  14481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14481
cagccucccg aguagcuaug                                                   20


<210>  14482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14482
uacucuguug ccuaaauugg                                                   20


<210>  14483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14483
caaaaauaaa auaaacuaaa                                                   20


<210>  14484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14484
uuuuauuuua guuuauuuua                                                   20


<210>  14485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14485
ugguugcagc uuugggcauc                                                   20


<210>  14486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14486
uuuaaacucu gccucguaaa                                                   20


<210>  14487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14487
uuaggcuggg aguauuuacg                                                   20


<210>  14488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14488
gcuaacccca auacauguua                                                   20


<210>  14489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14489
uuuaucuugu uuagaaauca                                                   20


<210>  14490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14490
ggaguggaau gcuuuuuuuu                                                   20


<210>  14491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14491
caacuugguc aggaguggaa                                                   20


<210>  14492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14492
aagugauugg ccaguaggcg                                                   20


<210>  14493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14493
ccuccuuccc cugacuggcc                                                   20


<210>  14494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14494
ggggaaggag gugacuucca                                                   20


<210>  14495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14495
ccugccauga gcaaucugug                                                   20


<210>  14496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14496
gggaggcggc ugcucagggu                                                   20


<210>  14497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14497
uguagaaucu aagagugacc                                                   20


<210>  14498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14498
cucuuagauu cuacaggacu                                                   20


<210>  14499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14499
uaguuuucuc aucuguagca                                                   20


<210>  14500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14500
ugguccugaa uccagugcca                                                   20


<210>  14501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14501
ugaauccagu gccaugccca                                                   20


<210>  14502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14502
ucgggccaca uggcugcugg                                                   20


<210>  14503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14503
cagggagggg gcugcugagg                                                   20


<210>  14504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14504
gcucacaugg ggaguaggag                                                   20


<210>  14505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14505
aggccuugaa ggcaaacucc                                                   20


<210>  14506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14506
cugcagcugc cuuccucgcu                                                   20


<210>  14507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14507
caucucagcu cacuccccga                                                   20


<210>  14508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14508
gggagugagc ugagaugaga                                                   20


<210>  14509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14509
gaguccuuuc uucaggaacc                                                   20


<210>  14510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14510
uuucuucagg aaccaucaag                                                   20


<210>  14511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14511
ccucuccuca gauagauuua                                                   20


<210>  14512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14512
uuagucuccu cuccucagau                                                   20


<210>  14513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14513
ggauagcuaa gcucuuuccu                                                   20


<210>  14514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14514
cugggccacu ccugaggcug                                                   20


<210>  14515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14515
ggcuagugag gcauaguucu                                                   20


<210>  14516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14516
ggccugaauu gcuaucaccc                                                   20


<210>  14517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14517
uaacccuucc auggaggggg                                                   20


<210>  14518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14518
aaacccaggc augggcauga                                                   20


<210>  14519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14519
ugcccaugcc uggguuuaga                                                   20


<210>  14520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14520
uuucugguca ugcccaugcc                                                   20


<210>  14521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14521
gcagaaugag ucacaauacc                                                   20


<210>  14522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14522
caauaccugc auccuaaucc                                                   20


<210>  14523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14523
ggggguuugu uggaggccac                                                   20


<210>  14524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14524
cuaugccacc cagguauugc                                                   20


<210>  14525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14525
aagcuaugac uaucuccuug                                                   20


<210>  14526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14526
uagcuuugac aaauacuuuu                                                   20


<210>  14527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14527
cuuccuugcc cuccacccag                                                   20


<210>  14528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14528
aaacuucccc uuuaaucuua                                                   20


<210>  14529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14529
ucucucagga cucaggaaac                                                   20


<210>  14530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14530
ugagagauga ccuggucgaa                                                   20


<210>  14531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14531
ucugccucug ucaccagcaa                                                   20


<210>  14532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14532
ccagcaaaua uaugcucagu                                                   20


<210>  14533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14533
cuuuacuuuu gaggccaguu                                                   20


<210>  14534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14534
ucaggcuuua gaaccagaag                                                   20


<210>  14535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14535
caguauguug cccaggcugg                                                   20


<210>  14536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14536
uaugaucgug gcucacugca                                                   20


<210>  14537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14537
cccaggcugg aaugcagucg                                                   20


<210>  14538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14538
ugcucuguca cccaggcugg                                                   20


<210>  14539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14539
uaaaaauaaa auaaaacaga                                                   20


<210>  14540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14540
uuagaugaaa aaggcuggaa                                                   20


<210>  14541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14541
cgaagguuaa aguccuuaga                                                   20


<210>  14542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14542
auucugaaaa aacaaggaau                                                   20


<210>  14543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14543
uuccuuguuu uuucagaaug                                                   20


<210>  14544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14544
ucuugucucu gccagccuua                                                   20


<210>  14545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14545
cugccagccu uagucccuuu                                                   20


<210>  14546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14546
cuuuuuuuuu uuuuuuuuuu                                                   20


<210>  14547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14547
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  14548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14548
cgcucuguca uccaagcugg                                                   20


<210>  14549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14549
uccaagcugg agcauagugg                                                   20


<210>  14550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14550
ucagcucaag caaguagcua                                                   20


<210>  14551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14551
aaguuugaaa gccagcuuuu                                                   20


<210>  14552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14552
auacugccug uuaggaaaca                                                   20


<210>  14553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14553
caaacucaca guaaagagcu                                                   20


<210>  14554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14554
ucaaauuccg ugguugcugc                                                   20


<210>  14555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14555
auuuuaaggc cggggguuga                                                   20


<210>  14556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14556
guuucauagu cauuuauccc                                                   20


<210>  14557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14557
uuuaucccac ucuggggaua                                                   20


<210>  14558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14558
caguaucagc cagagaagag                                                   20


<210>  14559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14559
caggccccag agaaugccuc                                                   20


<210>  14560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14560
cauaccuuag ugcugggaag                                                   20


<210>  14561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14561
agguggugcu cugcccaagg                                                   20


<210>  14562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14562
cugggagagg uccagguggu                                                   20


<210>  14563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14563
uccacaccag ccccuguccu                                                   20


<210>  14564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14564
uuuacccuug ggcccucucu                                                   20


<210>  14565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14565
caagaaaaaa aaaaaaaaaa                                                   20


<210>  14566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14566
cacucuuguc acccaggcug                                                   20


<210>  14567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14567
cccaggcugg acugcaguag                                                   20


<210>  14568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14568
agccugggug acaagaguga                                                   20


<210>  14569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14569
caguuaauuu ugguauuuuc                                                   20


<210>  14570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14570
ugaacuccug uccucaagug                                                   20


<210>  14571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14571
ucaagugacc uuggccuccc                                                   20


<210>  14572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14572
cuugaggaca ggaguucaag                                                   20


<210>  14573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14573
cugcgccugg ccuguuugcu                                                   20


<210>  14574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14574
guuuuaauug uguuaauaua                                                   20


<210>  14575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14575
ucaucccacc gucuaccucc                                                   20


<210>  14576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14576
accuccaaca cuuuuucauc                                                   20


<210>  14577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14577
cuaugaauuu acccaguaua                                                   20


<210>  14578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14578
auccauguug uagcauaugu                                                   20


<210>  14579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14579
aaauuucauu uauuuuuaug                                                   20


<210>  14580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14580
caggaaaaaa aaaaaaaaaa                                                   20


<210>  14581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14581
cccaggcugg agugcaaugg                                                   20


<210>  14582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14582
cuacuaaaaa uauaaaaauu                                                   20


<210>  14583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14583
ugaacuccug gugucaagug                                                   20


<210>  14584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14584
agugaucugc ccgccucggc                                                   20


<210>  14585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14585
caauaaacgc aaaguagaaa                                                   20


<210>  14586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14586
aaugguggaa ucacugugga                                                   20


<210>  14587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14587
ccaucuucuc uacauucuaa                                                   20


<210>  14588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14588
uuaaccauca auuaagcugg                                                   20


<210>  14589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14589
aaggccccca gcuuaauuga                                                   20


<210>  14590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14590
cagccaauuc acagaggucu                                                   20


<210>  14591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14591
ccggagaggg caccgaacca                                                   20


<210>  14592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14592
uggagggaag aagcagcaag                                                   20


<210>  14593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14593
ucugccuugc ugcuucuucc                                                   20


<210>  14594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14594
acagacuuca uuuuaugcug                                                   20


<210>  14595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14595
guagacuguu uuuuucucug                                                   20


<210>  14596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14596
ucacacacua cugaaagcuc                                                   20


<210>  14597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14597
ccaggguaga gcuuucagua                                                   20


<210>  14598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14598
agccaggucc ccaggguaga                                                   20


<210>  14599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14599
cagucucuca aucagugaaa                                                   20


<210>  14600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14600
cucaaucagu gaaauggagg                                                   20


<210>  14601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14601
ccuguguugc aaacuaaguu                                                   20


<210>  14602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14602
cuggcuuuug gaggaggcgu                                                   20


<210>  14603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14603
uggaggcggg gugaagcagu                                                   20


<210>  14604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14604
gcagcugccg gaaaugcugg                                                   20


<210>  14605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14605
agcccagaug gagcaagggc                                                   20


<210>  14606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14606
cacaggaaac ugaaguuaaa                                                   20


<210>  14607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14607
ggggaguggg aucacuaauu                                                   20


<210>  14608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14608
acuuugcuuu uuaaaaaugg                                                   20


<210>  14609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14609
cuggaguaac uuacuuuugu                                                   20


<210>  14610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14610
cuagaacggc cacaugcauc                                                   20


<210>  14611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14611
uacucuucgu ggcuucccuu                                                   20


<210>  14612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14612
uauuuuucca ucugauccug                                                   20


<210>  14613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14613
uugcagcugc cugacugaaa                                                   20


<210>  14614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14614
ggcagcugca aagaccacag                                                   20


<210>  14615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14615
cagugagaaa ggaagcaucu                                                   20


<210>  14616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14616
gggggccuag cuuacgucac                                                   20


<210>  14617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14617
cuccucuuag ccaggagucu                                                   20


<210>  14618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14618
uucccacacu uguucagugc                                                   20


<210>  14619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14619
ucacuccuug uugagacuug                                                   20


<210>  14620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14620
caacaaggag ugaagacacg                                                   20


<210>  14621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14621
ggauuuccuu aauaagauga                                                   20


<210>  14622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14622
aagaagcccc ugcaauaacc                                                   20


<210>  14623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14623
gccucaaggu uaacugaguu                                                   20


<210>  14624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14624
ccuaaugaug aaacucaguu                                                   20


<210>  14625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14625
ccaggucacc uaaugaugaa                                                   20


<210>  14626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14626
uccggccccu ucccucuccu                                                   20


<210>  14627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14627
cuaacuuuca cucuucagga                                                   20


<210>  14628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14628
gccccugccu aacccucucc                                                   20


<210>  14629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14629
auagcguccu cuugggcuug                                                   20


<210>  14630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14630
ucuugggcuu gagccaacgc                                                   20


<210>  14631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14631
cucagcaaac aucucauguc                                                   20


<210>  14632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14632
ucaagggcug gacaucccuu                                                   20


<210>  14633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14633
agcccuugag gacaugagau                                                   20


<210>  14634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14634
ccuugauguu ggcugcggag                                                   20


<210>  14635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14635
auagggcgca agcaugaaau                                                   20


<210>  14636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14636
uccaaaugcc uccuuuuuag                                                   20


<210>  14637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14637
gaggguaggg guagcacacu                                                   20


<210>  14638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14638
cgaucugcgu uuuagggagg                                                   20


<210>  14639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14639
gaggagggag gggcugcagg                                                   20


<210>  14640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14640
ucuguaagcc aggugaaaug                                                   20


<210>  14641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14641
acacacgauc ccacaugagu                                                   20


<210>  14642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14642
cuggcgggga gcucccuuca                                                   20


<210>  14643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14643
ucaucugugg agcccauggg                                                   20


<210>  14644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14644
uccccauggg cuccacagau                                                   20


<210>  14645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14645
ccaggugguc auccccaugg                                                   20


<210>  14646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14646
cugagaggau gcacucugug                                                   20


<210>  14647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14647
gugaauuccc ucucagggug                                                   20


<210>  14648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14648
guuccucuuu cccugggugg                                                   20


<210>  14649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14649
ucuccucucc aaaccacagg                                                   20


<210>  14650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14650
gcuugugagc cugugguuug                                                   20


<210>  14651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14651
uugcaggaac uucacuugag                                                   20


<210>  14652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14652
cugagagagg uccacgagcc                                                   20


<210>  14653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14653
acgagccacg cagggccacc                                                   20


<210>  14654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14654
gcguacacag cuuucuuucc                                                   20


<210>  14655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14655
cucaauuugc aucuuauaau                                                   20


<210>  14656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14656
augaacuaau gcaauuuuua                                                   20


<210>  14657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14657
guaauccagu cugccacugc                                                   20


<210>  14658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14658
gccacugcga agaagccuuu                                                   20


<210>  14659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14659
cagugcaaag aggugaaaaa                                                   20


<210>  14660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14660
ccagaauauu aaaguaaugu                                                   20


<210>  14661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14661
caauauuucu auagcuggca                                                   20


<210>  14662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14662
uagcacuuug aaaacuguaa                                                   20


<210>  14663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14663
gcuugguucc aaagaaggga                                                   20


<210>  14664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14664
auccuuucuc caccacccag                                                   20


<210>  14665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14665
uuugaacaug ggaagguguc                                                   20


<210>  14666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14666
acauuccuaa auggaaaucu                                                   20


<210>  14667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14667
ucucacuugc uucagauuuu                                                   20


<210>  14668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14668
cagcuagcag aacucuccuu                                                   20


<210>  14669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14669
cauuucagcc acugccagca                                                   20


<210>  14670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14670
uuaccagcgg agggcuccug                                                   20


<210>  14671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14671
uucgaggucu cucuccaggu                                                   20


<210>  14672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14672
cucuccaggu cuccacaggu                                                   20


<210>  14673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14673
ccacagguga aacuuuucca                                                   20


<210>  14674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14674
ucccagcaca cucacugggc                                                   20


<210>  14675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14675
caccaccaag aaugcuggua                                                   20


<210>  14676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14676
cucugaccuc uacccucugc                                                   20


<210>  14677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14677
gagagacgua ggaggccuug                                                   20


<210>  14678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14678
uguagcuuaa uuaccuuucc                                                   20


<210>  14679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14679
gaauucaaug ugauuuccag                                                   20


<210>  14680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14680
auagaacaga uguggggugg                                                   20


<210>  14681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14681
uugugucuau agaacagaug                                                   20


<210>  14682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14682
uauccucaga agcuguauuc                                                   20


<210>  14683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14683
uuauccucua guuucuguag                                                   20


<210>  14684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14684
uugagaucgu cauagucguu                                                   20


<210>  14685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14685
uagucguuac agaugaggca                                                   20


<210>  14686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14686
uuacagauga ggcauuuuuu                                                   20


<210>  14687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14687
agauagaugu guguauacgg                                                   20


<210>  14688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14688
cauauaguuc cuuguguaua                                                   20


<210>  14689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14689
gaaucauggu auauguaugg                                                   20


<210>  14690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14690
uacauacuau acuuggguua                                                   20


<210>  14691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14691
gcacaaggcu uaauccgugc                                                   20


<210>  14692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14692
gugagcaggc aaacuuccuu                                                   20


<210>  14693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14693
ccacucaagg ucuauaccuc                                                   20


<210>  14694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14694
auaccucacu uuuucauuac                                                   20


<210>  14695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14695
ugguaauagc agaguguuuu                                                   20


<210>  14696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14696
gagggguuca acacacaugg                                                   20


<210>  14697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14697
caagagaacg gccgggaggc                                                   20


<210>  14698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14698
ugaggugggg guguugcagg                                                   20


<210>  14699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14699
cagcaaugcc cacccugcaa                                                   20


<210>  14700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14700
caggagugga gaccacagag                                                   20


<210>  14701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14701
ccacuccugu gaccugccau                                                   20


<210>  14702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14702
uaauauuuag ggcauauaaa                                                   20


<210>  14703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14703
uaagucauaa uauuuagggc                                                   20


<210>  14704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14704
agugucuuaa gucauaauau                                                   20


<210>  14705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14705
uagacuaguc cugcuuccag                                                   20


<210>  14706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14706
augacugucc agugucuuaa                                                   20


<210>  14707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14707
ugcuuccagg agaaacagga                                                   20


<210>  14708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14708
uucccuaucu cucuccccca                                                   20


<210>  14709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14709
uaucaucugg uguccuuccc                                                   20


<210>  14710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14710
uaagucauau caucuggugu                                                   20


<210>  14711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14711
cuauuuuuga aaugcaagcu                                                   20


<210>  14712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14712
uguaauaaua uuauuuuauu                                                   20


<210>  14713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14713
caaacuccug gcuucaaaug                                                   20


<210>  14714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14714
uguuuuguug ccaggcuggu                                                   20


<210>  14715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14715
acaaaaagaa aaaaauucuu                                                   20


<210>  14716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14716
caaagcaaaa ugauaaaccu                                                   20


<210>  14717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14717
cauuaagcac uuaacacuuu                                                   20


<210>  14718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14718
uccuuugugu uguaaaaaua                                                   20


<210>  14719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14719
uuuguguugu aaaaauaguc                                                   20


<210>  14720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14720
aucccuagga acuaacuggc                                                   20


<210>  14721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14721
uuaucuuuag gcuguuugug                                                   20


<210>  14722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14722
uugauggguc uagaccagca                                                   20


<210>  14723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14723
agaccagcac aaauggggaa                                                   20


<210>  14724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14724
agacccauca aagacuguag                                                   20


<210>  14725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14725
augucuauuu gaauguguca                                                   20


<210>  14726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14726
auuugaaugu gucaaggaug                                                   20


<210>  14727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14727
aggaugacua cauaguuuaa                                                   20


<210>  14728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14728
uccuugacac auucaaauag                                                   20


<210>  14729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14729
cuuggcuugu uuugaauucc                                                   20


<210>  14730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14730
auagaaaagu uuuggaagag                                                   20


<210>  14731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14731
guuaaugauu auucaaaauc                                                   20


<210>  14732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14732
ggaguucaag accagccugg                                                   20


<210>  14733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14733
ugaacuccug accucaggcg                                                   20


<210>  14734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14734
cuacuaaaaa uacaaaaaau                                                   20


<210>  14735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14735
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  14736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14736
auaacauuuu cuuaaaucuu                                                   20


<210>  14737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14737
aaauuucucc auaacauggc                                                   20


<210>  14738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14738
augaaacuag uggaacauaa                                                   20


<210>  14739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14739
ggucagugcc cuccagacac                                                   20


<210>  14740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14740
gugcccucca gacacugcag                                                   20


<210>  14741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14741
ggagggcacu gaccagacca                                                   20


<210>  14742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14742
ucuuuucucu cugucaucua                                                   20


<210>  14743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14743
ucuaaauucu agccugucuu                                                   20


<210>  14744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14744
uugauggcua aaagccuaac                                                   20


<210>  14745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14745
uauggggggg cuaagauuau                                                   20


<210>  14746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14746
ucaaagggau uacaguuggu                                                   20


<210>  14747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14747
uguuccauuu ggaaugaauu                                                   20


<210>  14748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14748
guucagaagg uuaaaauacg                                                   20


<210>  14749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14749
acguauuuua accuucugaa                                                   20


<210>  14750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14750
cuuaucuuua caaagauugu                                                   20


<210>  14751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14751
uucuuguaaa uaacaacacc                                                   20


<210>  14752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14752
caggcaaagg gccugaguac                                                   20


<210>  14753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14753
gugccuuuua ccucuuugca                                                   20


<210>  14754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14754
ucccagcauc agaaauggac                                                   20


<210>  14755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14755
auuucugaug cugggaggac                                                   20


<210>  14756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14756
gcagaaccag agcccucaaa                                                   20


<210>  14757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14757
auucaaagug guuuugcuuu                                                   20


<210>  14758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14758
aaagguagag guugggagua                                                   20


<210>  14759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14759
uauaacuaca gaaugcuuac                                                   20


<210>  14760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14760
aagguuuugc aaauaguacu                                                   20


<210>  14761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14761
uuuaaagucu cucuaagcuu                                                   20


<210>  14762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14762
cucuaagcuu aaguagaaug                                                   20


<210>  14763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14763
guaaucccag cacuuuggga                                                   20


<210>  14764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14764
ggaguucgag accagucuaa                                                   20


<210>  14765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14765
cgaacuccug accucaggug                                                   20


<210>  14766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14766
aaucaacaua gugaaagccc                                                   20


<210>  14767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14767
cuacuaaaaa uauaaaaauu                                                   20


<210>  14768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14768
aauggcauga ucucagcuca                                                   20


<210>  14769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14769
gccaaucaag gacgagaagg                                                   20


<210>  14770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14770
uugauuggca gacugcccag                                                   20


<210>  14771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14771
gagaucacau uucagaaaca                                                   20


<210>  14772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14772
cucuucaccc cuuuuccugc                                                   20


<210>  14773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14773
ugcacacauu uuuuacacag                                                   20


<210>  14774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14774
ucaugcacac auuuuuuaca                                                   20


<210>  14775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14775
cagaaaaaaa gcagcaagcg                                                   20


<210>  14776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14776
auguuaaggg ugggcuuuuc                                                   20


<210>  14777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14777
ugauggccac ggggaugugg                                                   20


<210>  14778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14778
acacuccagu cccaagaggc                                                   20


<210>  14779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14779
caagaggccg gaacacaaga                                                   20


<210>  14780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14780
cccacugcug ugacuguugc                                                   20


<210>  14781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14781
cagcaguggg agacauucuu                                                   20


<210>  14782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14782
uuccuuuuuc agagggagga                                                   20


<210>  14783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14783
caugcagaaa gaggggacac                                                   20


<210>  14784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14784
ccucuuucug caugugacac                                                   20


<210>  14785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14785
gcauggcaau gauaaagcca                                                   20


<210>  14786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14786
agaccaaaaa gcacaggaac                                                   20


<210>  14787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14787
ggacugguaa auggugcugu                                                   20


<210>  14788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14788
gagggaaaag aaaaugugcu                                                   20


<210>  14789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14789
uuugugugga uuugccugca                                                   20


<210>  14790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14790
cucugaaaua gaagcaugag                                                   20


<210>  14791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14791
cucuucuaga auacguagaa                                                   20


<210>  14792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14792
gcuugcauua ccaucuaagg                                                   20


<210>  14793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14793
cagaccaucc ucaacaggga                                                   20


<210>  14794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14794
gagacgaagu aauuugccug                                                   20


<210>  14795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14795
uucuccuauu ucagggaggg                                                   20


<210>  14796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14796
uggggcccgg uagggcagca                                                   20


<210>  14797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14797
acccaugucc acuagaaaua                                                   20


<210>  14798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14798
acuagaaaua aaugugaauc                                                   20


<210>  14799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14799
cccuuugauu cacauuuauu                                                   20


<210>  14800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14800
ggaguuugag accagccugg                                                   20


<210>  14801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14801
caaacuccug accucaggug                                                   20


<210>  14802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14802
cccaggcugg agugcagugg                                                   20


<210>  14803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14803
cacccugucu cccaggcugg                                                   20


<210>  14804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14804
agagaaugga acagauugug                                                   20


<210>  14805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14805
cacaaucugu uccauucucu                                                   20


<210>  14806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14806
uuggagauga auuugguuug                                                   20


<210>  14807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14807
cucagcaauu cuuggucucc                                                   20


<210>  14808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14808
ccagguuuau uucuaccguu                                                   20


<210>  14809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14809
caaccugaau ggauucuucu                                                   20


<210>  14810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14810
uaggaauacu auuuuagaaa                                                   20


<210>  14811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14811
gccugcccca uacggaaaac                                                   20


<210>  14812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14812
cuagggagag auuugccacu                                                   20


<210>  14813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14813
cccagcuccu gugcaaagga                                                   20


<210>  14814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14814
gaauuggaac ccaagucucc                                                   20


<210>  14815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14815
auucuuuucu uaucuaauuu                                                   20


<210>  14816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14816
guuuuucuau cuuaguuuaa                                                   20


<210>  14817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14817
uugucuguuu uucuaucuua                                                   20


<210>  14818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14818
uggaacuucu cacuuccagu                                                   20


<210>  14819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14819
cuccuaggca gucagaggaa                                                   20


<210>  14820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14820
gaggaaagaa auauaauauu                                                   20


<210>  14821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14821
gguggaaguu ccaaaauaac                                                   20


<210>  14822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14822
aagcuaugug gcauacugua                                                   20


<210>  14823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14823
ccggaaguaa uaguaggauu                                                   20


<210>  14824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14824
auguuaaccu cacuaucaaa                                                   20


<210>  14825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14825
acgcauacaa aaccugaaag                                                   20


<210>  14826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14826
ggaauaucuu ucagguuuug                                                   20


<210>  14827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14827
aacugagugc cccaaaccuu                                                   20


<210>  14828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14828
uucucuccca ucauggaccc                                                   20


<210>  14829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14829
augaugggag agaaagacac                                                   20


<210>  14830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14830
guuagaauug ggguccauga                                                   20


<210>  14831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14831
gggcgcggug gcuuacaccu                                                   20


<210>  14832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14832
ggaguucgag accagccuga                                                   20


<210>  14833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14833
cgaacuccug accucaugag                                                   20


<210>  14834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14834
ggcuggucuc gaacuccuga                                                   20


<210>  14835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14835
cuacuaaaaa uacaaaaauu                                                   20


<210>  14836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14836
cacucuauug cccaggcugg                                                   20


<210>  14837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14837
ccuccaucca aguggcuggg                                                   20


<210>  14838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14838
cagccacuug gauggaggag                                                   20


<210>  14839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14839
ucuagucugu gcucauguca                                                   20


<210>  14840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14840
gugcucaugu caggcaacca                                                   20


<210>  14841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14841
ggcaaccaau uuaucucucu                                                   20


<210>  14842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14842
ucucugcaga guggaacuuc                                                   20


<210>  14843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14843
agaucauggu uauccaugaa                                                   20


<210>  14844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14844
ucccaaauug ucaaucuugu                                                   20


<210>  14845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14845
aucuuguaug ggguuucaaa                                                   20


<210>  14846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14846
agcccuaggc caggugaggu                                                   20


<210>  14847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14847
ccaucuccug aucucgugau                                                   20


<210>  14848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14848
cagcuacuug ggaagcugag                                                   20


<210>  14849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14849
uugccacugc acuccagccu                                                   20


<210>  14850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14850
cccaggcugg agugcagugg                                                   20


<210>  14851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14851
uaaaaaaaaa aaaaaaaaaa                                                   20


<210>  14852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14852
uucaacuuua aaagccaugg                                                   20


<210>  14853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14853
uuucccaugg cuuuuaaagu                                                   20


<210>  14854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14854
uuuuguucug uuuguuuuga                                                   20


<210>  14855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14855
guuuguaaau aaguggauau                                                   20


<210>  14856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14856
guguuucuac ccccacuuuu                                                   20


<210>  14857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14857
cuacacuuuc auuucugguc                                                   20


<210>  14858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14858
caagacccag gauuguuguu                                                   20


<210>  14859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14859
ugagacaagu ucagccuuug                                                   20


<210>  14860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14860
cucuuucuag gcaucagcaa                                                   20


<210>  14861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14861
uauguuucag caacacauag                                                   20


<210>  14862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14862
ggaaguccca acuaauugau                                                   20


<210>  14863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14863
caacuaauug auaggaaguc                                                   20


<210>  14864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14864
caaacaggcc acucgugcaa                                                   20


<210>  14865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14865
uggaaaagcc acaggggaaa                                                   20


<210>  14866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14866
guauguguaa gccacaugug                                                   20


<210>  14867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14867
gugaacauuu augacuuaug                                                   20


<210>  14868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14868
uaaauguuca cagacacaca                                                   20


<210>  14869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14869
agagcuaauu ucaccaaacu                                                   20


<210>  14870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14870
ugagaucugu cccagagagc                                                   20


<210>  14871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14871
cagagagcag gugaaauaau                                                   20


<210>  14872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14872
cgugcauuau uucaccugcu                                                   20


<210>  14873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14873
acaguaguga acuaccuuau                                                   20


<210>  14874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14874
uuauuuauua ugaauaagca                                                   20


<210>  14875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14875
gagcucuauu auugacaaac                                                   20


<210>  14876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14876
auaauagagc ucagacaccu                                                   20


<210>  14877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14877
guucugaugu gaacuucuuu                                                   20


<210>  14878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14878
gcauuaagau auauuuccug                                                   20


<210>  14879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14879
guaguuucuu auuaaauauu                                                   20


<210>  14880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14880
uuuaauuuag cuuaggaaag                                                   20


<210>  14881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14881
gacaguuagg aaaaccacac                                                   20


<210>  14882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14882
gacuuauaau uugcauacca                                                   20


<210>  14883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14883
guaggaaaca gguacagaag                                                   20


<210>  14884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14884
uauaagcauu aaaaauuaaa                                                   20


<210>  14885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14885
auguuaagca cacuuuuuaa                                                   20


<210>  14886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14886
uuuaaaaagu gugcuuaaca                                                   20


<210>  14887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14887
ccaaccccuu guuucuauac                                                   20


<210>  14888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14888
ugagugaugc ccuggcccuu                                                   20


<210>  14889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14889
acgggcccuc ucuaugggac                                                   20


<210>  14890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14890
cauagagagg gcccguggac                                                   20


<210>  14891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14891
guuuuuuugu uuuuacuuuu                                                   20


<210>  14892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14892
uuccagccua ggccugcagc                                                   20


<210>  14893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14893
ugcagagucc uuccagccua                                                   20


<210>  14894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14894
ucgcacaacg gcuucuugga                                                   20


<210>  14895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14895
gaaaacauca caaacuagca                                                   20


<210>  14896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14896
uccugcuagu uugugauguu                                                   20


<210>  14897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14897
gucauccugc uaguuuguga                                                   20


<210>  14898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14898
gcguggucug ucauccugcu                                                   20


<210>  14899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14899
acugggcggc acgcguccac                                                   20


<210>  14900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14900
acgucagcgu ggucugucau                                                   20


<210>  14901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14901
accccacccc ugggggcuuc                                                   20


<210>  14902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14902
ccaaccucuu ucuagguucu                                                   20


<210>  14903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14903
caccuguacu uuuuuuuucc                                                   20


<210>  14904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14904
agccacuggc aucuuaagca                                                   20


<210>  14905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14905
gagauacuug gggaggggag                                                   20


<210>  14906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14906
ucuucccaug ccucccuccc                                                   20


<210>  14907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14907
ucccaugccu cccucccuuc                                                   20


<210>  14908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14908
ccccaaggag gacccagguc                                                   20


<210>  14909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14909
uccuuggggg gacggaaggg                                                   20


<210>  14910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14910
ccccaccccu gcccaauugu                                                   20


<210>  14911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14911
uaauaaacuc gggacacacc                                                   20


<210>  14912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14912
cgaguuuauu aggacuauca                                                   20


<210>  14913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14913
uaagggcaag uguuuccuuc                                                   20


<210>  14914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14914
uuugguugag gagagcggga                                                   20


<210>  14915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14915
ccuuucccuc cucccucucc                                                   20


<210>  14916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14916
ucaaguucaa cgucaaagca                                                   20


<210>  14917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14917
aagcagccaa ugauuuacaa                                                   20


<210>  14918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14918
acagcaaggg aggaaccccg                                                   20


<210>  14919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14919
auguccacag caagggagga                                                   20


<210>  14920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14920
ggaugugccg aggaagaggg                                                   20


<210>  14921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14921
ccauggcaac gaggccugga                                                   20


<210>  14922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14922
ggggagagga ggccccaggc                                                   20


<210>  14923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14923
ggaucucagc ugcucucacg                                                   20


<210>  14924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14924
ccgcugcucu gcucaggggu                                                   20


<210>  14925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14925
agguggguuc uggggaaucc                                                   20


<210>  14926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14926
agcgcuaagu cacugucguc                                                   20


<210>  14927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14927
cugucgucga ggccccuuua                                                   20


<210>  14928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14928
ucgaggcccc uuuagcugau                                                   20


<210>  14929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14929
aggccccuuu agcugauacc                                                   20


<210>  14930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14930
aaccugcuac caauauucaa                                                   20


<210>  14931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14931
auuagaauuu gaauauuggu                                                   20


<210>  14932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14932
uuguacuuga gaaccuaaac                                                   20


<210>  14933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14933
cuuucccauu uggaagggag                                                   20


<210>  14934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14934
ugggauacca uuaauuccuc                                                   20


<210>  14935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14935
ucuacgguca ugggauacca                                                   20


<210>  14936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14936
cuggccucgu gcuguaugua                                                   20


<210>  14937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14937
gcacuucugc uugcuggcau                                                   20


<210>  14938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14938
ggucugcacu ucugcuugcu                                                   20


<210>  14939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14939
acaguucaua gcuauagcag                                                   20


<210>  14940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14940
auuucucuaa caauggguuc                                                   20


<210>  14941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14941
ccuaaagccc ugcauauuuc                                                   20


<210>  14942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14942
uuuaagaaac auuuuuccaa                                                   20


<210>  14943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14943
gaaaaaaaga gaaugggaug                                                   20


<210>  14944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14944
cugggccugg uguguucagg                                                   20


<210>  14945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14945
uaagaaguca uguucaugug                                                   20


<210>  14946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14946
uguucaugug uguacggagg                                                   20


<210>  14947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14947
cugugagcaa aguacuacaa                                                   20


<210>  14948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14948
gugaauaaac caccucauuu                                                   20


<210>  14949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14949
uaaacaaaga gaggauagca                                                   20


<210>  14950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14950
agccuguuac aaaaacuuac                                                   20


<210>  14951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14951
cuuaaaaucc ucaaguaagu                                                   20


<210>  14952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14952
auaagucagg agacuaagua                                                   20


<210>  14953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14953
ggagacuaag uaaccugaag                                                   20


<210>  14954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14954
ccugacuuau ugacgccuuc                                                   20


<210>  14955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14955
caaaguuaaa uaaauuuacu                                                   20


<210>  14956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14956
guucaaauuu cuuaaaucaa                                                   20


<210>  14957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14957
gucaggaugc aaaaccuaau                                                   20


<210>  14958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14958
ggaugcaaaa ccuaauuacg                                                   20


<210>  14959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14959
cuauuacucu uuuauuagga                                                   20


<210>  14960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14960
auaaaaccuc uguguguccc                                                   20


<210>  14961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14961
aagucaccac aucuaaagcu                                                   20


<210>  14962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14962
ccacaucuaa agcuggcaug                                                   20


<210>  14963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14963
ugagcagcau uuuggauuca                                                   20


<210>  14964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14964
cugaacuuag aaaagauaua                                                   20


<210>  14965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14965
auguuuucug aaaagccagu                                                   20


<210>  14966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14966
ugccuuuuau cugaggcaag                                                   20


<210>  14967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14967
cucaguucuu augcccuagu                                                   20


<210>  14968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14968
ucuuguggua gcauuuuuug                                                   20


<210>  14969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14969
uauucauuca ucuacacugg                                                   20


<210>  14970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14970
cuguucccag uguagaugaa                                                   20


<210>  14971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14971
cuuuuacaaa uacugcaugu                                                   20


<210>  14972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14972
auuuuaaaaa uccuuagaaa                                                   20


<210>  14973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14973
gaagauaauu gaaggguauu                                                   20


<210>  14974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14974
uccaggaaga cccuaucaaa                                                   20


<210>  14975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14975
uccuggauga cagcaaauaa                                                   20


<210>  14976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14976
ggcuacaccc cuaguggcug                                                   20


<210>  14977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14977
cucucuuuuu uucucccucu                                                   20


<210>  14978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14978
uuucucauaa caaaauaacc                                                   20


<210>  14979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14979
aaaaguucuu uucuauucuc                                                   20


<210>  14980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14980
gauguuaaaa acuuacucca                                                   20


<210>  14981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14981
aggguuugag auaugucuau                                                   20


<210>  14982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14982
auuuuaauau aguaaguacu                                                   20


<210>  14983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14983
uuuucaggau uauuucuaug                                                   20


<210>  14984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14984
gucuuuuuca ggauuauuuc                                                   20


<210>  14985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14985
aaugaggaca caagaagcuu                                                   20


<210>  14986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14986
ucauuugaca cacucuguaa                                                   20


<210>  14987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14987
cuuuauugaa aaaauaaaaa                                                   20


<210>  14988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14988
gcauuaaccu guucauacac                                                   20


<210>  14989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14989
guguuuuuuu ggcaguuguc                                                   20


<210>  14990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14990
uuguuaaguu cuauuggaaa                                                   20


<210>  14991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14991
uuacaaccug gcuuuuuauu                                                   20


<210>  14992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14992
ucuaaauaaa aaaaaaaaua                                                   20


<210>  14993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14993
cuauuuauua uugcuuaugu                                                   20


<210>  14994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14994
uaacuugaaa uuuuaucuuu                                                   20


<210>  14995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14995
auacuuuuuu guaaauggca                                                   20


<210>  14996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14996
cuuuccuucu aucacccuac                                                   20


<210>  14997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14997
uagggguugu acauauccuu                                                   20


<210>  14998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14998
cauggauggc ugucauaggg                                                   20


<210>  14999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  14999
cacuuuuuug uuucucucuu                                                   20


<210>  15000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15000
uuuuuuuuuc cacuaccaaa                                                   20


<210>  15001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15001
uuuuucugua uuucuagaau                                                   20


<210>  15002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15002
uguaacacca ccaagacaau                                                   20


<210>  15003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15003
uggugguguu acaagacuug                                                   20


<210>  15004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15004
aaguaaguaa gcucaauagu                                                   20


<210>  15005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15005
aguaaauggc uggcaaaguu                                                   20


<210>  15006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15006
auacuuaagg gaaaaguugc                                                   20


<210>  15007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15007
uaucugagca gguuuauuuu                                                   20


<210>  15008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15008
agugcuauuu gaacaccaac                                                   20


<210>  15009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15009
gugcucccua aaaguuguac                                                   20


<210>  15010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15010
cauuuaaaug caagucuuaa                                                   20


<210>  15011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15011
uaagaauuca uaguuaauca                                                   20


<210>  15012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15012
aaccuuauug ucagccucuu                                                   20


<210>  15013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15013
gccucuuccu uucaauaugg                                                   20


<210>  15014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15014
uaaaguuuau cauuugauug                                                   20


<210>  15015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15015
acuugacaac caaguagauc                                                   20


<210>  15016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15016
aguggacaau caaaugauaa                                                   20


<210>  15017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15017
uuuuaaaaau acuggcacca                                                   20


<210>  15018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15018
uaguuaauca ucauuuuucc                                                   20


<210>  15019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15019
ucuuuuuagg uagccauugu                                                   20


<210>  15020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15020
auucaaggcc uuuuuucuuc                                                   20


<210>  15021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15021
cuaaaggguu aaauguauca                                                   20


<210>  15022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15022
gucucuaaag gguuaaaugu                                                   20


<210>  15023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15023
auagaggguu aauccaaaga                                                   20


<210>  15024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15024
uuggauuaac ccucuauaga                                                   20


<210>  15025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15025
uuuucucucu cucucucuuu                                                   20


<210>  15026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15026
cuaauucguu gcugagcaaa                                                   20


<210>  15027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15027
aaguuuaaaa aaaaacauac                                                   20


<210>  15028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15028
ccagcacacc uguuuuuuuu                                                   20


<210>  15029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15029
caugugauuu aaacaaacaa                                                   20


<210>  15030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15030
ggugggagug agggaggggu                                                   20


<210>  15031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15031
uuccccaccu ggccaugcgu                                                   20


<210>  15032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15032
acaggagaag ccacacgggc                                                   20


<210>  15033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15033
ucaagaacug uagcaaucuc                                                   20


<210>  15034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15034
cugcgucugc ccucuuuuga                                                   20


<210>  15035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15035
gcccucuuuu gagcugggcc                                                   20


<210>  15036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15036
gggcccgggc aggcccagcu                                                   20


<210>  15037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15037
agcuccccgg gcggugugga                                                   20


<210>  15038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15038
gagcacuccu cggagaacgg                                                   20


<210>  15039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15039
ggagucuccg aagcuaagga                                                   20


<210>  15040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15040
ccgaagcuaa ggaagggauc                                                   20


<210>  15041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15041
aacuccuucu cgagcuugau                                                   20


<210>  15042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15042
aaaaagcugc ugcugggcag                                                   20


<210>  15043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15043
gccucggggg gccuguccaa                                                   20


<210>  15044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15044
augcgguccg acucgccggc                                                   20


<210>  15045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15045
gacucgccgg ccaccgaguc                                                   20


<210>  15046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15046
gaccgcauag acgauggcac                                                   20


<210>  15047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15047
ucgucgcaag ugucccugug                                                   20


<210>  15048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15048
caaguguccc uguggcccuc                                                   20


<210>  15049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15049
cuguggcccu cggccucggc                                                   20


<210>  15050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15050
ugggcgagaa gcauaagcgc                                                   20


<210>  15051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15051
ugcagggcau ggugcucagc                                                   20


<210>  15052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15052
ggcagggcgc ggcucucguc                                                   20


<210>  15053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15053
cccacgccca cgaccgcgcc                                                   20


<210>  15054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15054
ugggcguggg cgacgagagc                                                   20


<210>  15055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15055
acccucucgc ucuccgucag                                                   20


<210>  15056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15056
gcuccuccuc cuccucuucc                                                   20


<210>  15057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15057
uccuccucuu ccuccucguc                                                   20


<210>  15058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15058
uccucuuccu ccucgucccc                                                   20


<210>  15059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15059
ccguucuccg ggaucagguu                                                   20


<210>  15060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15060
uucucgcucu ugaacuuggc                                                   20


<210>  15061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15061
gugguggcca aguucaagag                                                   20


<210>  15062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15062
cuggugccgg guuccgggga                                                   20


<210>  15063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15063
cuccaccgcc agcuccccgg                                                   20


<210>  15064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15064
ucggacuuga ccgucauggg                                                   20


<210>  15065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15065
gacuugaccg ucauggggga                                                   20


<210>  15066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15066
gacgacgguc ucuccaccgc                                                   20


<210>  15067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15067
aguccgacga cggucucucc                                                   20


<210>  15068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15068
ugggggacga uuugugcaug                                                   20


<210>  15069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15069
cccaugacgg ucaaguccga                                                   20


<210>  15070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15070
ucauguggcg cuucagcuug                                                   20


<210>  15071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15071
cacagguugc acuuguaggg                                                   20


<210>  15072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15072
ugccgcagaa cucgcaugac                                                   20


<210>  15073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15073
ugcgaguucu gcggcaagac                                                   20


<210>  15074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15074
aagucaugcg aguucugcgg                                                   20


<210>  15075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15075
aguccaaguc augcgaguuc                                                   20


<210>  15076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15076
ccaggaaggg cggcuugcua                                                   20


<210>  15077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15077
ccaggccggc ccagcccuau                                                   20


<210>  15078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15078
agcccaccgc uguccccagg                                                   20


<210>  15079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15079
ccuagagaaa uccauggcgg                                                   20


<210>  15080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15080
aaggcacucg ggugaugggu                                                   20


<210>  15081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15081
aagugauguc ucgguggugg                                                   20


<210>  15082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15082
cgguggugga cuaaacaggg                                                   20


<210>  15083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15083
accaccgaga caucacuugg                                                   20


<210>  15084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15084
gcaauaugaa ucccauggag                                                   20


<210>  15085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15085
uucccagcca ccucuccaug                                                   20


<210>  15086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15086
ugaagggaua ccaacccgcg                                                   20


<210>  15087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15087
ggggacuucc guguucgcuu                                                   20


<210>  15088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15088
ccugaccccg cggguuggua                                                   20


<210>  15089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15089
gugagggcuu aggccuuggg                                                   20


<210>  15090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15090
gagcaugggu acccaguaaa                                                   20


<210>  15091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15091
aauugaucuu ccugccauua                                                   20


<210>  15092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15092
ggauuuuucu gcuuugggga                                                   20


<210>  15093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15093
cuacauucua ggcaccucaa                                                   20


<210>  15094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15094
ucuaaacuuu ccaguuccau                                                   20


<210>  15095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15095
aaguuucuca cuuaacaagg                                                   20


<210>  15096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15096
ccuuguccaa guuucucacu                                                   20


<210>  15097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15097
cccagggggg aauagaaagc                                                   20


<210>  15098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15098
acucacuaca auguucuaug                                                   20


<210>  15099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15099
uuuuuccacg gaaguauuuu                                                   20


<210>  15100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15100
ggggugugag aauguugcua                                                   20


<210>  15101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15101
caauuuuggu uccacaacac                                                   20


<210>  15102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15102
ccauggggug uuguggaacc                                                   20


<210>  15103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15103
auuuuuaucu caaagaaugu                                                   20


<210>  15104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15104
cccggucaga caaaugcaag                                                   20


<210>  15105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15105
gacaaaugca agucuggaaa                                                   20


<210>  15106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15106
gaccggggga caacuccuaa                                                   20


<210>  15107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15107
ggaaaaguua ggaggagugg                                                   20


<210>  15108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15108
gcaccagcca cuccuccuaa                                                   20


<210>  15109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15109
gcuuaagucg gcaccagcca                                                   20


<210>  15110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15110
uggcgcuggc uguuuuaacu                                                   20


<210>  15111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15111
cagccgaggg cgcaggaugu                                                   20


<210>  15112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15112
acucuggcca guagccaagc                                                   20


<210>  15113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15113
ggagaggggc ccugcuuaag                                                   20


<210>  15114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15114
cauuauuucc cuugcugaaa                                                   20


<210>  15115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15115
agcuggcccu ucuuugccaa                                                   20


<210>  15116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15116
guuauuccau auauauauau                                                   20


<210>  15117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15117
acugcaacau uaaaaagggc                                                   20


<210>  15118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15118
uuuggcuacc auuacuucug                                                   20


<210>  15119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15119
guaacuuucu aagaaggaaa                                                   20


<210>  15120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15120
gaaagaaaag ccggcagggu                                                   20


<210>  15121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15121
ucucaggagc ccccaaacac                                                   20


<210>  15122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15122
aaauaaugga cuccugcccu                                                   20


<210>  15123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15123
auuauuuaga caagugcuug                                                   20


<210>  15124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15124
gggcaggagu ccauuauuua                                                   20


<210>  15125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15125
aauguggaag ggggaaaaaa                                                   20


<210>  15126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15126
gcguuuucuu ucaaaaucuu                                                   20


<210>  15127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15127
caaauaggcu ggaaaaaaaa                                                   20


<210>  15128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15128
ucccuagauc ucugggugac                                                   20


<210>  15129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15129
cccagagauc uagggaggac                                                   20


<210>  15130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15130
ggcuaaauag gaaugauagu                                                   20


<210>  15131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15131
gauaauccaa guccuuaaca                                                   20


<210>  15132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15132
uuaacacguu caucacucca                                                   20


<210>  15133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15133
uggauuucaa ucgauguuuu                                                   20


<210>  15134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15134
aguccuggau uucaaucgau                                                   20


<210>  15135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15135
uugauaaaug ccaaaaucug                                                   20


<210>  15136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15136
auuuuauuuu gcugcccuga                                                   20


<210>  15137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15137
gagaaaaugg cauuuuaucu                                                   20


<210>  15138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15138
augagaaggg cuguuacgau                                                   20


<210>  15139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15139
caaucguaac agcccuucuc                                                   20


<210>  15140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15140
acuaauagca aaugaugcau                                                   20


<210>  15141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15141
ucaauaaaug uguuacuugc                                                   20


<210>  15142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15142
uucuaaauca ucaaagaugu                                                   20


<210>  15143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15143
guuuauugcu cuaaaucaaa                                                   20


<210>  15144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15144
caaguuccua ugcuuagggg                                                   20


<210>  15145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15145
uuccuuccca uaaaguaaaa                                                   20


<210>  15146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15146
ccaaugugaa aaagucaugu                                                   20


<210>  15147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15147
ugugaucuaa gccucaagau                                                   20


<210>  15148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15148
gagacuggag gccuagcucu                                                   20


<210>  15149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15149
cagaccuccu uguucuucug                                                   20


<210>  15150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15150
uuugauuucu cugagucuug                                                   20


<210>  15151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15151
uggaauuccu aucuguaaaa                                                   20


<210>  15152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15152
uuugaacuuc ccaacaauuc                                                   20


<210>  15153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15153
aaugugaaug ugaguuuuca                                                   20


<210>  15154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15154
uuacccucag uaauuaauca                                                   20


<210>  15155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15155
caguccaggc cuuaacccag                                                   20


<210>  15156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15156
aggccuuaac ccaggccaaa                                                   20


<210>  15157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15157
ccccugcucu uuaacuagag                                                   20


<210>  15158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15158
agaaagcucu agaacaaacc                                                   20


<210>  15159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15159
cuccuaaauu gguccugcca                                                   20


<210>  15160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15160
ugccagcagg ggcaccagca                                                   20


<210>  15161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15161
ucucccaccu ucccacaaag                                                   20


<210>  15162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15162
gagcuugaua gggaaccccu                                                   20


<210>  15163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15163
aaucaaacuc ccagcccuca                                                   20


<210>  15164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15164
uccugagggc ugggaguuug                                                   20


<210>  15165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15165
ucagccuggu cuuccugagg                                                   20


<210>  15166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15166
cugcaugcug gcuggguggg                                                   20


<210>  15167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15167
cagauugcag aagguuuagg                                                   20


<210>  15168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15168
ugagggcugg gugguucagg                                                   20


<210>  15169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15169
cagggugcau gcccugcucu                                                   20


<210>  15170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15170
ucucccuccc aucuaaaaac                                                   20


<210>  15171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15171
cccuuagagc cuuaacucug                                                   20


<210>  15172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15172
uggagagaga auaacaaaga                                                   20


<210>  15173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15173
cacuucuuuu cuucuugaac                                                   20


<210>  15174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15174
auuuauacaa auguuuucug                                                   20


<210>  15175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15175
cuacuauaaa agcucacuug                                                   20


<210>  15176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15176
aaauuaugug ugggcaugaa                                                   20


<210>  15177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15177
guuuaggguu auuccagagu                                                   20


<210>  15178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15178
auggcacaca ucuuuagcca                                                   20


<210>  15179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15179
uaaaugaggc cacaggagug                                                   20


<210>  15180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15180
aguaauaaaa ugggcuccag                                                   20


<210>  15181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15181
ugcuccgugg cuagugauug                                                   20


<210>  15182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15182
ugucuugcuc cguggcuagu                                                   20


<210>  15183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15183
ucuccccagg gucuugucuu                                                   20


<210>  15184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15184
cucuggggcu gaguggagug                                                   20


<210>  15185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15185
uauguauuau uccauuacuc                                                   20


<210>  15186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15186
auguguauag agaugagaau                                                   20


<210>  15187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15187
uuuugacaaa agugaaaggg                                                   20


<210>  15188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15188
aaaagaccga aauugaaaac                                                   20


<210>  15189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15189
uugguucauu ugcuuauuua                                                   20


<210>  15190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15190
uguggaaaga agauguguaa                                                   20


<210>  15191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15191
auaaaguaaa guuaauguau                                                   20


<210>  15192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15192
cauaaaaaac gauucacaaa                                                   20


<210>  15193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15193
cacuuugcuu ucucuguccc                                                   20


<210>  15194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15194
cucugccccc cucuucccau                                                   20


<210>  15195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15195
agaaaugccc agguuucccc                                                   20


<210>  15196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15196
acuggaaacc uuacacagau                                                   20


<210>  15197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15197
aaucuuuauc uuccauugcu                                                   20


<210>  15198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15198
aaauaacuuu gaccauuaaa                                                   20


<210>  15199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15199
aaguuauuug gaccccagaa                                                   20


<210>  15200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15200
uuuaaugguc aaaguuauuu                                                   20


<210>  15201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15201
ggguuucugg gugcuggcau                                                   20


<210>  15202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15202
ucaccagagu acaacaaagu                                                   20


<210>  15203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15203
cuugucuuca ccagaguaca                                                   20


<210>  15204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15204
augaaacauu uguagcacug                                                   20


<210>  15205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15205
uccucuagcu aacuaaccau                                                   20


<210>  15206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15206
aucuugagac agacuggagg                                                   20


<210>  15207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15207
caagauggac agcuacaugg                                                   20


<210>  15208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15208
gucucaagau ggacagcuac                                                   20


<210>  15209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15209
ccugcaccau cuauccucca                                                   20


<210>  15210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15210
cccgcccucc ccaaucauca                                                   20


<210>  15211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15211
guuuuucuug ucucccgccc                                                   20


<210>  15212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15212
caaguguaaa auacauccug                                                   20


<210>  15213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15213
caacugccuu ggcugugcuu                                                   20


<210>  15214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15214
guguaagagc cuucucagca                                                   20


<210>  15215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15215
gcuguuacca ggccugcaga                                                   20


<210>  15216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15216
cuguagaugu ucucaggcua                                                   20


<210>  15217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15217
gagaggauga aaugucucug                                                   20


<210>  15218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15218
uccugcuugu guugguucac                                                   20


<210>  15219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15219
ggucuuccug cuuguguugg                                                   20


<210>  15220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15220
acauuugacu guuuacguca                                                   20


<210>  15221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15221
aauguagaca uacuuguuug                                                   20


<210>  15222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15222
agugaauuga gaguguggcg                                                   20


<210>  15223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15223
ugguauuuuu caaugagaaa                                                   20


<210>  15224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15224
guuuuggcag caaacuuagu                                                   20


<210>  15225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15225
cuucccagag uaaguggcag                                                   20


<210>  15226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15226
acaaacccau uagcccuaaa                                                   20


<210>  15227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15227
gcuuguuuag ggcuaauggg                                                   20


<210>  15228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15228
ugccgucagc uuguuuaggg                                                   20


<210>  15229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15229
ggccgugugg caaagugagg                                                   20


<210>  15230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15230
caucugacua ucuggcagca                                                   20


<210>  15231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15231
gaugagaccu cacuuugcca                                                   20


<210>  15232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15232
gucccuucau uuuacagaug                                                   20


<210>  15233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15233
cuucauuuua cagaugggga                                                   20


<210>  15234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15234
cuuaauuucu cauggccuca                                                   20


<210>  15235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15235
ggagauuaau ucuaaucuuc                                                   20


<210>  15236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15236
uuccugggaa uuugucucuu                                                   20


<210>  15237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15237
cuuccccccu gcugcuccug                                                   20


<210>  15238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15238
ucacugccca acaagaaggu                                                   20


<210>  15239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15239
uguuucuacu gauccauuaa                                                   20


<210>  15240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15240
ugggggaggg uccagcccag                                                   20


<210>  15241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15241
agcccagcag cgcuacaugg                                                   20


<210>  15242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15242
guucauuggc accuuucgaa                                                   20


<210>  15243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15243
cacaauugga aaacaaggcc                                                   20


<210>  15244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15244
aauucugcag gggaagcaga                                                   20


<210>  15245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15245
uugugagacu cacccuugca                                                   20


<210>  15246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15246
cacaaagaca gugugcuuuu                                                   20


<210>  15247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15247
aagcaaagcc aacuggggac                                                   20


<210>  15248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15248
ccaguuggcu uugcuuugac                                                   20


<210>  15249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15249
auuuuacuua ccaaagagaa                                                   20


<210>  15250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15250
aacucgagga gcagcucugc                                                   20


<210>  15251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15251
ucuuuuuuuc uuuguuagug                                                   20


<210>  15252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15252
gcgcugugag aaucacuugc                                                   20


<210>  15253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15253
gagguggugc ccaagaauuu                                                   20


<210>  15254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15254
uaggguaagg gaaguaugaa                                                   20


<210>  15255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15255
cugcccaggg aauuucaaag                                                   20


<210>  15256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15256
aggacccacc uccuuuagga                                                   20


<210>  15257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15257
uggacaggag ggaaaacagc                                                   20


<210>  15258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15258
uaaaggaggu ggguccugga                                                   20


<210>  15259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15259
aaaacaaauu aagcuuaggg                                                   20


<210>  15260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15260
gucauugaua aggacaggga                                                   20


<210>  15261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15261
uugauaagga cagggaacag                                                   20


<210>  15262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15262
uuaucaauga cagacggagg                                                   20


<210>  15263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15263
aggcucucca ucagguccag                                                   20


<210>  15264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15264
agggccuucu uagcaugaga                                                   20


<210>  15265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15265
caugcuaaga aggcccugga                                                   20


<210>  15266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15266
ggcacaagcu gguuugggug                                                   20


<210>  15267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15267
ucacugcuuc cauuaaagcc                                                   20


<210>  15268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15268
gcuuuaaugg aagcagugag                                                   20


<210>  15269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15269
gcgaacgcag cuguggcaac                                                   20


<210>  15270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15270
gugcaguugc cacagcugcg                                                   20


<210>  15271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15271
aguuccugcu guguccgugc                                                   20


<210>  15272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15272
cucaaauggg acacauuucc                                                   20


<210>  15273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15273
cauuugagag accagaaagg                                                   20


<210>  15274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15274
gaaaagggaa auguguccca                                                   20


<210>  15275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15275
uacacuuuuc ugguggaagg                                                   20


<210>  15276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15276
cucuagaccc aguauuucca                                                   20


<210>  15277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15277
agagagaccu uuaugaaaua                                                   20


<210>  15278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15278
cuauuuuuaa auucagccau                                                   20


<210>  15279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15279
cuuuacauuu cuacauauau                                                   20


<210>  15280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15280
aaaguuggua cccaauauau                                                   20


<210>  15281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15281
uuaaaucaag uuuuuugguu                                                   20


<210>  15282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15282
aggaaucuuu gagauguucu                                                   20


<210>  15283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15283
acuaaucaac agguaauacu                                                   20


<210>  15284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15284
uuaaacgugu uggaaugaug                                                   20


<210>  15285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15285
ugugguuuua auaccuguua                                                   20


<210>  15286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15286
caauauacac acaugcacau                                                   20


<210>  15287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15287
guguacgugu gugaaugugu                                                   20


<210>  15288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15288
cacugaaaaa aaaaaaaaaa                                                   20


<210>  15289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15289
cacguggaau gggcuaucuc                                                   20


<210>  15290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15290
cgagauagcc cauuccacgu                                                   20


<210>  15291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15291
cagugucacg agauagccca                                                   20


<210>  15292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15292
ucaaaaagag aauggaugac                                                   20


<210>  15293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15293
uccauucucu uuuugaagac                                                   20


<210>  15294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15294
cuauauuggu gacaggccaa                                                   20


<210>  15295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15295
ccaauauaga gaccccuccu                                                   20


<210>  15296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15296
uguauuuugg ccugucacca                                                   20


<210>  15297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15297
uuucgcaguc cauaauccuc                                                   20


<210>  15298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15298
auaauccuca agucccucag                                                   20


<210>  15299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15299
cucagcucuu ccauguacca                                                   20


<210>  15300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15300
agaagguggu acauggaaga                                                   20


<210>  15301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15301
gagcuagagg cuucuuuacc                                                   20


<210>  15302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15302
uuucuauuca gccgcaucua                                                   20


<210>  15303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15303
agagcuagau gcggcugaau                                                   20


<210>  15304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15304
gagaaucuaa gugagaagaa                                                   20


<210>  15305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15305
caggcauagc uaauguuugc                                                   20


<210>  15306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15306
aucuguaaug aaaaugugcc                                                   20


<210>  15307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15307
gugagugaug auaaagcugg                                                   20


<210>  15308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15308
aaaucgcacu cucuuuuguu                                                   20


<210>  15309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15309
auaauuauug cuuucuuuug                                                   20


<210>  15310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15310
uuagauuccu ugauacuuca                                                   20


<210>  15311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15311
cuggugaagu aucaaggaau                                                   20


<210>  15312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15312
ucucuacuuc cucccuuuau                                                   20


<210>  15313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15313
ggccuaaaca aaauuuuucu                                                   20


<210>  15314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15314
uuaacauaag caaagcauau                                                   20


<210>  15315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15315
uuggcuuagu ugcuuuucag                                                   20


<210>  15316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15316
ccuagauaag uuccgccauu                                                   20


<210>  15317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15317
uuuuaugcag cugcccucuc                                                   20


<210>  15318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15318
uaggacaauu uuuuuuuguu                                                   20


<210>  15319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15319
uaagacaauu ugucuuuuua                                                   20


<210>  15320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15320
guguuuucuu uguacugccc                                                   20


<210>  15321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15321
ugagagaggu acagaugagc                                                   20


<210>  15322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15322
acuggaugaa ucagugugca                                                   20


<210>  15323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15323
uauccuccgc ugucaacugg                                                   20


<210>  15324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15324
cagaaaucuu cagaggauuu                                                   20


<210>  15325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15325
cuuauuuuca gaaaauguga                                                   20


<210>  15326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15326
acaugguugu gucccuuauu                                                   20


<210>  15327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15327
gacaaacaag uguugauagc                                                   20


<210>  15328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15328
gacucagagg aauaaaacau                                                   20


<210>  15329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15329
cauugccagu uuaagauggg                                                   20


<210>  15330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15330
gcaaguacaa gcccaucuua                                                   20


<210>  15331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15331
uuuguugaaa augugucagc                                                   20


<210>  15332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15332
cuucaaucau caacuugacc                                                   20


<210>  15333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15333
aguugaugau ugaagagaca                                                   20


<210>  15334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15334
ucagcugagg aucuuguuug                                                   20


<210>  15335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15335
cugcuuccua aaggaagaaa                                                   20


<210>  15336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15336
cuccagagga acaagucccu                                                   20


<210>  15337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15337
ggaaccuaag uucugcaacc                                                   20


<210>  15338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15338
cgaaacagcu ggugaguggc                                                   20


<210>  15339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15339
ucuccuuuua aagauggaaa                                                   20


<210>  15340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15340
aggccuccuu uggaccaacc                                                   20


<210>  15341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15341
aaaggaggcc uggacuugca                                                   20


<210>  15342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15342
cuugguuggu ccaaaggagg                                                   20


<210>  15343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15343
ugaggggaac agguguaucc                                                   20


<210>  15344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15344
aggucaugag gggaacaggu                                                   20


<210>  15345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15345
ccaggcuaau ccuuaggcuu                                                   20


<210>  15346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15346
caggagguug aaauccauca                                                   20


<210>  15347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15347
ugcaaaguuu acaugucuga                                                   20


<210>  15348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15348
gagcuucaag gaggaaaccu                                                   20


<210>  15349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15349
ugagccaaug agacugaagg                                                   20


<210>  15350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15350
cauuggcuca ggacacaccu                                                   20


<210>  15351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15351
gagaaccagg aagaaacuuc                                                   20


<210>  15352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15352
agggaaaagg ucucaguggc                                                   20


<210>  15353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15353
caguggcuca ugccagaagu                                                   20


<210>  15354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15354
aguagcaaag cucggccuca                                                   20


<210>  15355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15355
ugugugugcc uuugugagca                                                   20


<210>  15356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15356
ucuccccagc caccacaaac                                                   20


<210>  15357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15357
ugguuugugg uggcugggga                                                   20


<210>  15358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15358
uugaccuccc accacacccc                                                   20


<210>  15359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15359
aggaccacag ggugcugggc                                                   20


<210>  15360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15360
cccuuccagg cucauugaaa                                                   20


<210>  15361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15361
uccuuccccc aacccccaau                                                   20


<210>  15362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15362
aguaguuaau gaucuguaaa                                                   20


<210>  15363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15363
cuucuaacua caaaggcaug                                                   20


<210>  15364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15364
uuuaucgucc cuucuaacua                                                   20


<210>  15365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15365
cccgaauugu ccagcuucac                                                   20


<210>  15366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15366
agcuucacac aaacguauca                                                   20


<210>  15367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15367
aaaugaugau uucccauccu                                                   20


<210>  15368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15368
aucaaagcca gcagaacaca                                                   20


<210>  15369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15369
ucagaguaau uugggaguug                                                   20


<210>  15370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15370
ugagaaaaua cuagaauaag                                                   20


<210>  15371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15371
cuuggaaaca ccauguuuga                                                   20


<210>  15372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15372
cucacagcac cacugccccu                                                   20


<210>  15373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15373
gcaagugugg gcagccccag                                                   20


<210>  15374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15374
cuggggcugc ccacacuugc                                                   20


<210>  15375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15375
ggaaagcccu ccaccuggcc                                                   20


<210>  15376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15376
uggaugauaa gucaggaaag                                                   20


<210>  15377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15377
gugcacggag aaggggccag                                                   20


<210>  15378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15378
ggccuccccc aaggccaaca                                                   20


<210>  15379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15379
uggccuuuau ggaaagcuuu                                                   20


<210>  15380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15380
caauuaaaaa aaaaaaaaaa                                                   20


<210>  15381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15381
cacucuguug cccaggcugg                                                   20


<210>  15382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15382
uccugccuca gcucucaagu                                                   20


<210>  15383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15383
uagcuacuug agagcugagg                                                   20


<210>  15384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15384
cccuguggaa ugagggaagg                                                   20


<210>  15385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15385
ugcuguggac agggaggaca                                                   20


<210>  15386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15386
acagcaggac acuucugaga                                                   20


<210>  15387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15387
ucccugucca cagcaggaca                                                   20


<210>  15388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15388
ugaagcccag cccuguccuc                                                   20


<210>  15389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15389
gaaggugggc aggguccuga                                                   20


<210>  15390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15390
ucuggacacu ggucauacag                                                   20


<210>  15391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15391
ggacacuggu cauacagccc                                                   20


<210>  15392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15392
agacgacagg uuucugccgc                                                   20


<210>  15393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15393
uacagccccu uucaggcaau                                                   20


<210>  15394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15394
cucaauagug ccagaaaggc                                                   20


<210>  15395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15395
acacaccagu cacucaauag                                                   20


<210>  15396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15396
cagaguauua ggccugugaa                                                   20


<210>  15397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15397
uggccaagag auucugagaa                                                   20


<210>  15398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15398
uaugguuaac acagagcugc                                                   20


<210>  15399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15399
agcaggucag gcucuaacau                                                   20


<210>  15400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15400
ggcucuaaca uuucuucagg                                                   20


<210>  15401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15401
ugggaggagg ccuggccucg                                                   20


<210>  15402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15402
uucuuucaga aaacaggccu                                                   20


<210>  15403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15403
ucaucucucu ggcaaagucc                                                   20


<210>  15404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15404
cacagaacaa aacacaggcc                                                   20


<210>  15405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15405
aagccaaggc cuguguuuug                                                   20


<210>  15406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15406
gugguauaaa ugaaggauua                                                   20


<210>  15407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15407
agccaugggg uguggcacug                                                   20


<210>  15408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15408
guucuuggcu cuacuaauuc                                                   20


<210>  15409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15409
gggaacauug gauguuacuc                                                   20


<210>  15410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15410
acguggggac ucagccuaug                                                   20


<210>  15411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15411
ccacguggac cugcuaggug                                                   20


<210>  15412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15412
auaggcugag uccccacgug                                                   20


<210>  15413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15413
caccguggug uguggccgcu                                                   20


<210>  15414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15414
ccggguccca ccguggugug                                                   20


<210>  15415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15415
cucuaagacu gcuugggaaa                                                   20


<210>  15416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15416
uagagagacu caaaacaaaa                                                   20


<210>  15417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15417
cucaggucua gcauuuccac                                                   20


<210>  15418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15418
agcauuucca cgcaguccca                                                   20


<210>  15419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15419
caaccaugag gcugaccaga                                                   20


<210>  15420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15420
gccucauggu ugggacugcg                                                   20


<210>  15421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15421
agcucucuca ggucuacuag                                                   20


<210>  15422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15422
acuaggaaca ggaaagaaua                                                   20


<210>  15423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15423
ccggcccaca gaucucagcu                                                   20


<210>  15424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15424
ggcgguggag aguguggacg                                                   20


<210>  15425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15425
acacucucca ccgccugaca                                                   20


<210>  15426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15426
gccugccguc cacacucucc                                                   20


<210>  15427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15427
gccucuuuga aaccgcguca                                                   20


<210>  15428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15428
uguacuccug ccccagcucu                                                   20


<210>  15429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15429
uuuaucaaug uaauucaagg                                                   20


<210>  15430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15430
agggucuguc accauuuuaa                                                   20


<210>  15431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15431
gucaccauuu uaaagaggcu                                                   20


<210>  15432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15432
ccauuuuaaa gaggcuuauu                                                   20


<210>  15433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15433
cacgcugaua ccuuacaugc                                                   20


<210>  15434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15434
cucccuucca ccaaccguuu                                                   20


<210>  15435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15435
acuucagauu ucuuuccucc                                                   20


<210>  15436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15436
caaccuguca acuucagauu                                                   20


<210>  15437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15437
gccaagagcc gcaggccaua                                                   20


<210>  15438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15438
acagcuugcu ccacaccgga                                                   20


<210>  15439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15439
ucucaguggg gccuccuccc                                                   20


<210>  15440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15440
uuggugcaga guggggcagu                                                   20


<210>  15441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15441
ccagcccccu ggccuccagc                                                   20


<210>  15442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15442
cucuucugaa ccuggcucuc                                                   20


<210>  15443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15443
cccuguaauc agcauguauc                                                   20


<210>  15444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15444
ugguucuuag aagccuugaa                                                   20


<210>  15445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15445
accucugacu guccagcacc                                                   20


<210>  15446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15446
gagguagacc acugagucuu                                                   20


<210>  15447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15447
agcaccaugc ugggcaaaga                                                   20


<210>  15448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15448
uuuagaaugg cucuccaaca                                                   20


<210>  15449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15449
uuccagccag gucauuuaga                                                   20


<210>  15450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15450
cugcuggcuc cauggccugg                                                   20


<210>  15451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15451
gccuugaccc aggagaggau                                                   20


<210>  15452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15452
aggcugaccc agaggcuccu                                                   20


<210>  15453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15453
aucgcuucac uguacuauuu                                                   20


<210>  15454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15454
auaacaacca uugaguaaau                                                   20


<210>  15455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15455
aauuuccuua agucuucugg                                                   20


<210>  15456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15456
ucuggugaau uggucucaau                                                   20


<210>  15457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15457
caauuacuag ucuggguccc                                                   20


<210>  15458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15458
gggucccuuu cuuccuuccu                                                   20


<210>  15459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15459
cuuucuuccu uccucucuca                                                   20


<210>  15460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15460
caagagaaag aacaguguga                                                   20


<210>  15461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15461
agcuuccuag ccuuauuuuu                                                   20


<210>  15462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15462
cccaaguugc acuagauccu                                                   20


<210>  15463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15463
caagcagaga uggguggcua                                                   20


<210>  15464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15464
cccacgaccu acaccaggcc                                                   20


<210>  15465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15465
ugggagacag agagaaggcc                                                   20


<210>  15466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15466
gagggucacc cagggcuaga                                                   20


<210>  15467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15467
cccagggcua gaacuuaagc                                                   20


<210>  15468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15468
uccuucaccu gccagcuugu                                                   20


<210>  15469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15469
ccuugauccc uguccuccuu                                                   20


<210>  15470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15470
acgcuggccc cuggcuaaga                                                   20


<210>  15471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15471
uguuuuucuu gacgcuccac                                                   20


<210>  15472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15472
agaaaaacaa gacaaaaaaa                                                   20


<210>  15473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15473
aaaggcucuc ccaccaucac                                                   20


<210>  15474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15474
uggaaugagc ucagcaugcu                                                   20


<210>  15475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15475
guguguugag gcuuuucccc                                                   20


<210>  15476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15476
cuauaccuag guggguuucc                                                   20


<210>  15477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15477
guucuagucc ugcugucaaa                                                   20


<210>  15478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15478
ugcugucaaa agaaaggggu                                                   20


<210>  15479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15479
aaagaaaggg guuggacuga                                                   20


<210>  15480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15480
aaccccuuuc uuuugacagc                                                   20


<210>  15481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15481
uuuuuggacc uaacauccag                                                   20


<210>  15482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15482
aaaaaugaca aacaagcccu                                                   20


<210>  15483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15483
cuucugacuc ccaggaagag                                                   20


<210>  15484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15484
gaagugaccu ugaugaacug                                                   20


<210>  15485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15485
gccucucuuc cugggaguca                                                   20


<210>  15486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15486
uaaguggcuc aaaccacccg                                                   20


<210>  15487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15487
aaaauguccu aaguggcuca                                                   20


<210>  15488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15488
gcuccgugaa caggaaacag                                                   20


<210>  15489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15489
caugccccuu ucccacucug                                                   20


<210>  15490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15490
cucuauucuu cuugcuuccu                                                   20


<210>  15491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15491
gaaaauggaa uugcuccuuc                                                   20


<210>  15492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15492
ucugcccugu uuucaggaag                                                   20


<210>  15493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15493
uucaaaauag aauuuuugag                                                   20


<210>  15494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15494
ucagaaagag augauuacac                                                   20


<210>  15495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15495
aguuggauau uuaaaauguc                                                   20


<210>  15496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15496
agcuggaaga ucauugauug                                                   20


<210>  15497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15497
ccacugaaac aaaucuuucu                                                   20


<210>  15498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15498
aacuuuugcu gauaaaugcu                                                   20


<210>  15499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15499
ugacaagggg aagaccagga                                                   20


<210>  15500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15500
agaccauuuc ucuaccacgg                                                   20


<210>  15501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15501
uccccuuguc aagaccauuu                                                   20


<210>  15502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15502
ucuuuuccug gucuuccccu                                                   20


<210>  15503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15503
caauuugagg caucgauuua                                                   20


<210>  15504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15504
gaagacuuga gaccaggcaa                                                   20


<210>  15505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15505
ucugaccuug gccagggauc                                                   20


<210>  15506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15506
caagucuucu gaccuuggcc                                                   20


<210>  15507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15507
cagaugaucu caggcaaguc                                                   20


<210>  15508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15508
ccagguauag cugcaguccc                                                   20


<210>  15509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15509
cuuuagcccc agucuguuuc                                                   20


<210>  15510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15510
guuucucugu ccaaggcaga                                                   20


<210>  15511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15511
aaggcagaac ccaaaucaac                                                   20


<210>  15512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15512
augucaugug uuuugauugu                                                   20


<210>  15513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15513
uguguuuuga uuguaauauu                                                   20


<210>  15514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15514
gaguuguuga acacagugcc                                                   20


<210>  15515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15515
gaaauaacuc aagagaggau                                                   20


<210>  15516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15516
ccaggaaaca ucaaaugaau                                                   20


<210>  15517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15517
gcuaauaugc cagcucauuc                                                   20


<210>  15518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15518
gcugaagcau ccagauacau                                                   20


<210>  15519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15519
ccaaauucuu ccuuuguugu                                                   20


<210>  15520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15520
aagcacucgc ccaaagcacu                                                   20


<210>  15521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15521
cauagcuucu guuaaaaauc                                                   20


<210>  15522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15522
caaugcagau aaucauuaca                                                   20


<210>  15523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15523
ugucgaacag cuuuacucua                                                   20


<210>  15524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15524
aacagcuuua cucuaauuua                                                   20


<210>  15525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15525
cuaucgacag cucaugcuuu                                                   20


<210>  15526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15526
auagugaccu gcauuugcag                                                   20


<210>  15527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15527
gugacaguug uuggguugcc                                                   20


<210>  15528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15528
cagacgaagc aucaaaagca                                                   20


<210>  15529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15529
agacucugac agugucagaa                                                   20


<210>  15530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15530
ggacaacccu gccagcuccu                                                   20


<210>  15531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15531
gagucuggac aacccugcca                                                   20


<210>  15532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15532
gaaaaugcag ucaccacggc                                                   20


<210>  15533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15533
ccacggcugc uucacaggaa                                                   20


<210>  15534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15534
gcacacaguc aguuucccug                                                   20


<210>  15535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15535
guuucccugu agcccagaag                                                   20


<210>  15536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15536
ucaacaacug ggguccucug                                                   20


<210>  15537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15537
ucugcuguca aaaacagcca                                                   20


<210>  15538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15538
aaaacagcca cauucaccag                                                   20


<210>  15539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15539
gcagccgcac cuggugaggc                                                   20


<210>  15540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15540
aggcuguacu uccaacaugg                                                   20


<210>  15541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15541
ggggagaugg gagaaggggu                                                   20


<210>  15542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15542
ugaacacaca ccccuucucc                                                   20


<210>  15543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15543
uaaacaagug ccacagagga                                                   20


<210>  15544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15544
acuugcgaaa uuguggcugc                                                   20


<210>  15545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15545
cugcaaauaa augcagucau                                                   20


<210>  15546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15546
uccagagugu aauggaaguc                                                   20


<210>  15547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15547
ggccuuggag uuacuggcuu                                                   20


<210>  15548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15548
gggcuauggc cucucacccc                                                   20


<210>  15549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15549
cugugccguu cagucugggc                                                   20


<210>  15550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15550
ucuucguucu uggcuagcag                                                   20


<210>  15551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15551
caggaauguc cuccaugccu                                                   20


<210>  15552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15552
uccaugccuu uaagcuaacu                                                   20


<210>  15553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15553
gcccuggcuc acaccguucu                                                   20


<210>  15554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15554
agguuuauuu uucccuuaua                                                   20


<210>  15555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15555
cgaagcugcu gaauauuagg                                                   20


<210>  15556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15556
cagcaaccua gauaugagaa                                                   20


<210>  15557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15557
cgagugaaag gcaacuucac                                                   20


<210>  15558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15558
aacacagucu auaaauacca                                                   20


<210>  15559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15559
auaaauacca gcaaugcccc                                                   20


<210>  15560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15560
cacagcaauu ccaggucccc                                                   20


<210>  15561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15561
cccagaagua gcccuucacc                                                   20


<210>  15562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15562
agaguagaga acugugacaa                                                   20


<210>  15563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15563
caguucucua cucuugaccu                                                   20


<210>  15564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15564
aauccauuuc agaauggaga                                                   20


<210>  15565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15565
ugccuuucag cagcuguuca                                                   20


<210>  15566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15566
cccuaggaug ucuugccuuu                                                   20


<210>  15567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15567
uuguucugug gguggaccau                                                   20


<210>  15568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15568
acccacagaa caaggacccu                                                   20


<210>  15569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15569
uucucuggaa aggagccaug                                                   20


<210>  15570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15570
cacuuugaug uguaggagag                                                   20


<210>  15571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15571
uuagaaauua ucucucaaaa                                                   20


<210>  15572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15572
guggauaggg aaaauuucaa                                                   20


<210>  15573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15573
aucacagggc uguggucugu                                                   20


<210>  15574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15574
gguaauaauc ugccagcuaa                                                   20


<210>  15575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15575
accaucuaau gcuaucaagg                                                   20


<210>  15576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15576
cacuguaaua ccucugucaa                                                   20


<210>  15577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15577
gagcccacag ucugagaaug                                                   20


<210>  15578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15578
gagaaugacc acaucccuuc                                                   20


<210>  15579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15579
uucucagacu gugggcucag                                                   20


<210>  15580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15580
cccugggaag ggaugugguc                                                   20


<210>  15581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15581
ucccagggug uugaguggga                                                   20


<210>  15582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15582
cucaaaccug gccauggcuc                                                   20


<210>  15583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15583
uuuuuauucu gauagaauag                                                   20


<210>  15584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15584
aacguugcua uucaggcauu                                                   20


<210>  15585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15585
agcgcuccua aaugccugaa                                                   20


<210>  15586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15586
auuagcuaag cucuucaugc                                                   20


<210>  15587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15587
gcagagccca uguuacaucu                                                   20


<210>  15588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15588
ggcuuucagg ugucugcacc                                                   20


<210>  15589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15589
gcaccccaca augccacaca                                                   20


<210>  15590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15590
ucuguaugga aauugggaaa                                                   20


<210>  15591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15591
ucucaaaugu agauuaucuu                                                   20


<210>  15592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15592
aaauauauga agaggaacau                                                   20


<210>  15593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15593
auguuccucu ucauauauuu                                                   20


<210>  15594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15594
guaaaccuuu aguggcagau                                                   20


<210>  15595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15595
aaaguaauag cacagagagg                                                   20


<210>  15596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15596
cacgggcugu ucaaagagug                                                   20


<210>  15597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15597
gauucacucc ucauguuccu                                                   20


<210>  15598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15598
ugauuuuaac ugaacaaugu                                                   20


<210>  15599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15599
ccaagaauuc agacugugag                                                   20


<210>  15600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15600
gaauucuugg agacauuguu                                                   20


<210>  15601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15601
ucuucccccu cucacagucu                                                   20


<210>  15602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15602
cuuuggugca gugggaauug                                                   20


<210>  15603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15603
ucccugguuc cucuccucug                                                   20


<210>  15604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15604
uuggcaaucc aguuacaauu                                                   20


<210>  15605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15605
aauuguaacu ggauugccaa                                                   20


<210>  15606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15606
ucuuuaaaug cugucaaauu                                                   20


<210>  15607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15607
uauuaucuca aguacuguca                                                   20


<210>  15608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15608
uuucuuucac auuugcugua                                                   20


<210>  15609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15609
uuuagguaau gucaucuaug                                                   20


<210>  15610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15610
ucuaugauca guuuuuguuu                                                   20


<210>  15611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15611
gcaaaaaaug aaacaaaaac                                                   20


<210>  15612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15612
cuaccaaaaa uacagaaauu                                                   20


<210>  15613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15613
ggcuggucuc aaacucccga                                                   20


<210>  15614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15614
caaacucccg accuuaggug                                                   20


<210>  15615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15615
ggaguuugag accagccuga                                                   20


<210>  15616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15616
uaaauaauag guggucaaaa                                                   20


<210>  15617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15617
aaauguuucu aaaggguacc                                                   20


<210>  15618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15618
aagguacccu uuagaaacau                                                   20


<210>  15619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15619
acacuagccc acaugccaau                                                   20


<210>  15620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15620
uugucaguca cuuacacuau                                                   20


<210>  15621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15621
gucacuuaca cuauuucuca                                                   20


<210>  15622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15622
cuuacacuau uucucauucc                                                   20


<210>  15623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15623
uuuugcccac aacauaucca                                                   20


<210>  15624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15624
ccuagaagcc cuuauuucuu                                                   20


<210>  15625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15625
uccuggauga ugaggcagcu                                                   20


<210>  15626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15626
cuuggcacac aguguggcug                                                   20


<210>  15627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15627
aacaagcuuu uguuuguggc                                                   20


<210>  15628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15628
gacauuugaa auucuaacag                                                   20


<210>  15629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15629
gacuuucuuu ucagcuuccu                                                   20


<210>  15630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15630
uagaggggaa agaaccucug                                                   20


<210>  15631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15631
cuagcaucuc ugcuuuccuu                                                   20


<210>  15632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15632
auuuacuaac cacuuuuauc                                                   20


<210>  15633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15633
uccugcuuug gggguuauua                                                   20


<210>  15634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15634
cauaucauca aaaugauaaa                                                   20


<210>  15635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15635
auccauguug ggauacucag                                                   20


<210>  15636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15636
cucuccucca guccauccau                                                   20


<210>  15637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15637
cuugucccuc uccuccaguc                                                   20


<210>  15638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15638
guauuggucc cuugucccuc                                                   20


<210>  15639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15639
uuccugccca cuccccaucu                                                   20


<210>  15640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15640
ucuauauuag uaacagaccc                                                   20


<210>  15641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15641
guuacuaaua uagaggacug                                                   20


<210>  15642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15642
accaacucca uccucuagaa                                                   20


<210>  15643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15643
acaggggaga acucggcaug                                                   20


<210>  15644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15644
ucacuuaaca uccccuagca                                                   20


<210>  15645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15645
ucugaucaga guauuucagc                                                   20


<210>  15646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15646
aacuccuuaa gccaucauuc                                                   20


<210>  15647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15647
uaguuccccg uacccaucaa                                                   20


<210>  15648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15648
accuagucac cuuagcaaga                                                   20


<210>  15649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15649
ccuuagcaag aagaaucaau                                                   20


<210>  15650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15650
gggaguggug caugggauga                                                   20


<210>  15651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15651
cuguauugaa gaaacucauu                                                   20


<210>  15652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15652
caugcugugc ugguacuuuc                                                   20


<210>  15653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15653
uuuauaugcu auuuguugaa                                                   20


<210>  15654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15654
gguuggcaca uaaacuucac                                                   20


<210>  15655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15655
gacagaguua ccaaaaaaug                                                   20


<210>  15656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15656
gacuuuacca accuggcgca                                                   20


<210>  15657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15657
uuuuuuggua acucugucag                                                   20


<210>  15658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15658
gcuauagagu ugcacaacca                                                   20


<210>  15659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15659
ucugcaaaga aguuagucuc                                                   20


<210>  15660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15660
cagccaccug cgcauccuca                                                   20


<210>  15661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15661
uuuuuaguag ugcugcauuu                                                   20


<210>  15662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15662
auguuugcug cccucuggca                                                   20


<210>  15663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15663
uaacuaucau uugaaaugcu                                                   20


<210>  15664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15664
ggaguucaag aucaguuugg                                                   20


<210>  15665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15665
aaacugaucu ugaacuccug                                                   20


<210>  15666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15666
cuacuaaaaa uacaaaauua                                                   20


<210>  15667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15667
caccaaaaaa agaaaaaaga                                                   20


<210>  15668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15668
gcccagccug gagaacugag                                                   20


<210>  15669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15669
aaacacccua ggcaucauca                                                   20


<210>  15670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15670
uaccuggcca cuuggcucuc                                                   20


<210>  15671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15671
gugccugcgu aguguugggu                                                   20


<210>  15672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15672
uuagcaccca aauagguuca                                                   20


<210>  15673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15673
acacaaaucu gccaaauaaa                                                   20


<210>  15674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15674
ucuccuuaag cggagaugcu                                                   20


<210>  15675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15675
uauucaucag uaugucuucu                                                   20


<210>  15676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15676
ccaacucagu cuuauucauc                                                   20


<210>  15677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15677
aggcaggagg aucacuggag                                                   20


<210>  15678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15678
ugaacuccug ggcuccagug                                                   20


<210>  15679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15679
ucccagcuac ucaggaggcu                                                   20


<210>  15680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15680
cagcuacuca ggaggcugag                                                   20


<210>  15681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15681
ccucagccuc cugaguagcu                                                   20


<210>  15682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15682
cgcuguguug ccuaggcuag                                                   20


<210>  15683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15683
caaaaacaaa caaacaaaca                                                   20


<210>  15684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15684
uuuguuuguu uguuuguuug                                                   20


<210>  15685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15685
gagaagcgca ugaguacugg                                                   20


<210>  15686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15686
uuaccaacuu cuauaaaauc                                                   20


<210>  15687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15687
uucaggguag caccaaagua                                                   20


<210>  15688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15688
ugaggagacc caaacaguua                                                   20


<210>  15689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15689
ccucaagacu cuagccgucu                                                   20


<210>  15690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15690
guaaccuuua acuguuuggg                                                   20


<210>  15691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15691
gucuguaacc uuuaacuguu                                                   20


<210>  15692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15692
uucauuuuaa guguacaguu                                                   20


<210>  15693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15693
accagucuag aaagcccccu                                                   20


<210>  15694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15694
agaaagcccc cucaugcccc                                                   20


<210>  15695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15695
auccccuucc cuaacccucu                                                   20


<210>  15696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15696
gaggguuagg gaaggggauu                                                   20


<210>  15697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15697
auuuguaaca aauucuagaa                                                   20


<210>  15698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15698
uuuguguuua auuucuucca                                                   20


<210>  15699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15699
caacccacau ggcaaccaau                                                   20


<210>  15700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15700
aaaagugguc acaacccaca                                                   20


<210>  15701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15701
auuguagcac uguucauagu                                                   20


<210>  15702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15702
acauuucucu uagguaaaca                                                   20


<210>  15703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15703
agggagcccu cauuuuguca                                                   20


<210>  15704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15704
uccuccaggc ugccccccuc                                                   20


<210>  15705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15705
uccuauuccg aauagaaacc                                                   20


<210>  15706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15706
cuucccauca uuuccuuagu                                                   20


<210>  15707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15707
aauuuauuug gccugauuca                                                   20


<210>  15708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15708
gagauaacuu aaguguggug                                                   20


<210>  15709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15709
uaagagcccc cacuagcuca                                                   20


<210>  15710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15710
auuucugagc uagugggggc                                                   20


<210>  15711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15711
acuaagucca uuucugagcu                                                   20


<210>  15712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15712
aggagaugac uucuaccuug                                                   20


<210>  15713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15713
ucuccuugac ucuccaugcu                                                   20


<210>  15714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15714
uucuucccaa ggccuuuggc                                                   20


<210>  15715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15715
cacacaacac uccagggagg                                                   20


<210>  15716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15716
acagcacugg gcagcagcug                                                   20


<210>  15717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15717
uucugcuucc uguucaccuc                                                   20


<210>  15718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15718
cccccagggg uccuucugcu                                                   20


<210>  15719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15719
cacuggaggc ccugucuccc                                                   20


<210>  15720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15720
acuuccccuc cacuccccgu                                                   20


<210>  15721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15721
uuuguccacu uccccuccac                                                   20


<210>  15722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15722
ugucuuuugu ccacuucccc                                                   20


<210>  15723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15723
aagauggcug uccugucuuu                                                   20


<210>  15724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15724
cuguucuguu uucuucaguu                                                   20


<210>  15725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15725
gcaucacccu cucucacucu                                                   20


<210>  15726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15726
ucccacucuc ccauguggcc                                                   20


<210>  15727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15727
cugcccaguu uagaggccau                                                   20


<210>  15728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15728
ccuccccacu cuggaccugg                                                   20


<210>  15729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15729
agagugggga ggugaccagg                                                   20


<210>  15730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15730
uauaaaucuu augcaauuuu                                                   20


<210>  15731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15731
ccuuugauau cucaucucac                                                   20


<210>  15732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15732
ggcuuugcca auuggagauu                                                   20


<210>  15733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15733
guauugcccc aagucuggcu                                                   20


<210>  15734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15734
ucacagaacc agucuguauu                                                   20


<210>  15735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15735
auauuuuaaa uuccagcuga                                                   20


<210>  15736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15736
gaagaaaagg gaaaagggag                                                   20


<210>  15737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15737
uauucuuuuc cuuuuuccuc                                                   20


<210>  15738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15738
gggggaggca agucaguugg                                                   20


<210>  15739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15739
guugggaaca cagauccuaa                                                   20


<210>  15740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15740
acccauccau cacauauagg                                                   20


<210>  15741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15741
ggcuguccac ccauccauca                                                   20


<210>  15742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15742
auuuuucauc ugucgggcug                                                   20


<210>  15743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15743
gcacucuccc cuccucauaa                                                   20


<210>  15744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15744
acacggcaug gcauacaaau                                                   20


<210>  15745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15745
gccaguccuc uucuacccca                                                   20


<210>  15746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15746
ucuucuaccc cacccacgcc                                                   20


<210>  15747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15747
agugcaagcu aacaguugcu                                                   20


<210>  15748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15748
auacaacuuu gaagcuaguc                                                   20


<210>  15749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15749
aagaguagau gccauaucuc                                                   20


<210>  15750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15750
auacagguaa uaacauaggc                                                   20


<210>  15751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15751
ugucuagcug ccuuccuuau                                                   20


<210>  15752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15752
agcugccuuc cuuaucacag                                                   20


<210>  15753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15753
aucaguaccu cagaguagaa                                                   20


<210>  15754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15754
gguuugccca uggggcacag                                                   20


<210>  15755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15755
ggcuguuuuc cagggugggg                                                   20


<210>  15756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15756
gcaccccacc cuggaaaaca                                                   20


<210>  15757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15757
uaacagacac acguaugugu                                                   20


<210>  15758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15758
guuaugacgu uauauguaag                                                   20


<210>  15759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15759
aaauauucuc aaugggcccu                                                   20


<210>  15760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15760
uugagcagga aaagaauuac                                                   20


<210>  15761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15761
aacuguaauu ccaggcucua                                                   20


<210>  15762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15762
uuuuucugag agucucuaaa                                                   20


<210>  15763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15763
cuaaauuaca aggguguuuu                                                   20


<210>  15764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15764
cccucauaug ugaaaaguca                                                   20


<210>  15765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15765
auugauaaug aaggcuuuag                                                   20


<210>  15766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15766
gaaaaacaaa ucaugacuua                                                   20


<210>  15767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15767
ugauuuguuu uuccgacuuc                                                   20


<210>  15768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15768
aauacacguu uacagaaugc                                                   20


<210>  15769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15769
cacgaggcaa cacaggcuac                                                   20


<210>  15770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15770
cccaucugug guagccugug                                                   20


<210>  15771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15771
acucccaccc ugucccccau                                                   20


<210>  15772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15772
agggcagaac uggagcuuug                                                   20


<210>  15773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15773
cugccuggga aaugguuuca                                                   20


<210>  15774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15774
gacaauaagu cugccauugu                                                   20


<210>  15775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15775
gacuggcagc accagccuag                                                   20


<210>  15776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15776
gccauugucc ucuggucagc                                                   20


<210>  15777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15777
ucuggucagc ucuggacaca                                                   20


<210>  15778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15778
gcucuggaca cacagcaaaa                                                   20


<210>  15779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15779
agagcugacc agaggacaau                                                   20


<210>  15780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15780
caaauccuug ccuugaaccu                                                   20


<210>  15781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15781
gugaggagag aggguuguac                                                   20


<210>  15782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15782
gggcuugcau uccauaaaug                                                   20


<210>  15783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15783
guguggucag ggcuugcauu                                                   20


<210>  15784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15784
uggcauguaa guaagucugu                                                   20


<210>  15785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15785
uacaucaacc ccuuccucaa                                                   20


<210>  15786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15786
cagucauagg ccugaaaagc                                                   20


<210>  15787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15787
uaggccugaa aagcagcaug                                                   20


<210>  15788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15788
ugcuuuacaa aaauucaguu                                                   20


<210>  15789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15789
auggggaaau ggguccugcu                                                   20


<210>  15790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15790
uaagagauga gugaacacaa                                                   20


<210>  15791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15791
ucacgauuac uucacgauaa                                                   20


<210>  15792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15792
cuuuggaauc cagauuuauc                                                   20


<210>  15793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15793
acucaacacu gggggaggag                                                   20


<210>  15794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15794
gcgguguacu cccuguccac                                                   20


<210>  15795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15795
uuccaugcag uagcuaauga                                                   20


<210>  15796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15796
uuagcuacug cauggaagga                                                   20


<210>  15797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15797
gauuuuucag aauaugaaua                                                   20


<210>  15798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15798
uuaaguuaau caaucccuag                                                   20


<210>  15799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15799
agacuuaaac ugccgcuccu                                                   20


<210>  15800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15800
agacuucaaa gcacucucau                                                   20


<210>  15801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15801
accuggaaug uucuaauuca                                                   20


<210>  15802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15802
cuaccuacgu cagugccaua                                                   20


<210>  15803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15803
gugccauauc cuauaauggu                                                   20


<210>  15804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15804
uuaucaucac cauuauagga                                                   20


<210>  15805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15805
agccuccuac ucuucucuuu                                                   20


<210>  15806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15806
uuugggggaa auaugugccu                                                   20


<210>  15807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15807
cauuucuccc uuugcugaug                                                   20


<210>  15808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15808
uaaaugaaac caagcuuccu                                                   20


<210>  15809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15809
aggcuccccc uucuaucacc                                                   20


<210>  15810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15810
uccucggcca augaagcggu                                                   20


<210>  15811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15811
ggguguugca gagauugcua                                                   20


<210>  15812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15812
cucaucuccc caccuccaug                                                   20


<210>  15813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15813
gccagguggg ucccucaucu                                                   20


<210>  15814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15814
ucucuuuggg ggaggacauc                                                   20


<210>  15815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15815
ucccccaaag agaagacccc                                                   20


<210>  15816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15816
aaagucuggg agaauggagg                                                   20


<210>  15817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15817
gggagaaugg agguguggag                                                   20


<210>  15818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15818
gaccccaagc aggaagggcc                                                   20


<210>  15819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15819
gacccaguua uccccuccac                                                   20


<210>  15820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15820
acauagaggc ccuuccugcu                                                   20


<210>  15821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15821
ccuuaaggag ccacacaccc                                                   20


<210>  15822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15822
gaagaggccc uggacacuga                                                   20


<210>  15823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15823
agggccucuu cugacaggcc                                                   20


<210>  15824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15824
ccaaggcugu gcccagccuu                                                   20


<210>  15825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15825
ugugagcggu ccccaaggcu                                                   20


<210>  15826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15826
gcacacacug cugcaugucc                                                   20


<210>  15827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15827
cgguagggag uugucggcac                                                   20


<210>  15828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15828
gcacugauag gggucgcggu                                                   20


<210>  15829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15829
agcccagccu gggugugcau                                                   20


<210>  15830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15830
cacaagauca cagggugugc                                                   20


<210>  15831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15831
caggccaauu cuaggaaggg                                                   20


<210>  15832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15832
gaucaccucu gcucagcucu                                                   20


<210>  15833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15833
ccucaucugc cugcuuccuu                                                   20


<210>  15834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15834
ucuauagguc caaguucgua                                                   20


<210>  15835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15835
aaguucguac agacccagcc                                                   20


<210>  15836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15836
guacgaacuu ggaccuauag                                                   20


<210>  15837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15837
ggcugggucu guacgaacuu                                                   20


<210>  15838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15838
cuagcuccuc agagaacugg                                                   20


<210>  15839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15839
ucugaguuug aucaagauuu                                                   20


<210>  15840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15840
aacucaucca gaaacuacgu                                                   20


<210>  15841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15841
aauagaacag gaagcaggug                                                   20


<210>  15842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15842
ccacacaggc auccaaaggg                                                   20


<210>  15843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15843
auuucucgcu ggcuuuucug                                                   20


<210>  15844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15844
cggggcccaa gccaaagagc                                                   20


<210>  15845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15845
ugcucuacca ggccuuaggu                                                   20


<210>  15846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15846
cucccacaga gcugcagggg                                                   20


<210>  15847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15847
caccccugca gcucuguggg                                                   20


<210>  15848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15848
aagcccaucg ugccuuauuc                                                   20


<210>  15849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15849
aucagccuau ugggccucag                                                   20


<210>  15850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15850
ggggccaccu agccagcagg                                                   20


<210>  15851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15851
uuucaccugc uggcuaggug                                                   20


<210>  15852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15852
gcuacacaug agucuuuuca                                                   20


<210>  15853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15853
aagcuccuuc aacgucccac                                                   20


<210>  15854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15854
cacuuucuca agacaguguu                                                   20


<210>  15855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15855
ugagaaagug ggacguugaa                                                   20


<210>  15856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15856
uuuugcuagc ccuggcccgu                                                   20


<210>  15857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15857
gugaggccca ggaacaugaa                                                   20


<210>  15858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15858
ggggagcuuc auguuccugg                                                   20


<210>  15859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15859
accccuuugg uccggggagc                                                   20


<210>  15860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15860
ccuuccacau gcuguggccc                                                   20


<210>  15861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15861
ucucuuccuc cuaauccaua                                                   20


<210>  15862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15862
ggugcuuaug gauuaggagg                                                   20


<210>  15863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15863
agcagcuucc ggagcugcac                                                   20


<210>  15864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15864
ugcuugaggu cuagcagcuu                                                   20


<210>  15865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15865
guggcugcuc ucuccgaauc                                                   20


<210>  15866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15866
ccugucugcu cuacuguagc                                                   20


<210>  15867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15867
gcucuacugu agcucccucc                                                   20


<210>  15868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15868
ucugcccagg ccugccugag                                                   20


<210>  15869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15869
gggcuuugcc cugggcacug                                                   20


<210>  15870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15870
ugugcugccc ccacagcuuu                                                   20


<210>  15871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15871
ugagagugaa aguggacaag                                                   20


<210>  15872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15872
acuuucacuc ucaagaccac                                                   20


<210>  15873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15873
agcccaggcg gggaggggac                                                   20


<210>  15874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15874
ccuccccgcc ugggcuugac                                                   20


<210>  15875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15875
gcccacagag gcacgguuaa                                                   20


<210>  15876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15876
cuuccauucu ucugccauuu                                                   20


<210>  15877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15877
gguuuauucc aucaauacac                                                   20


<210>  15878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15878
ugaggaguug ggaagugugg                                                   20


<210>  15879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15879
cuguguagca gccaccagcc                                                   20


<210>  15880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15880
uauaccuuaa cugguggagg                                                   20


<210>  15881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15881
gggcaccuca cuucaagccu                                                   20


<210>  15882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15882
aacuugggag ccugaguguu                                                   20


<210>  15883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15883
gggagcagcu cuuuaaccuc                                                   20


<210>  15884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15884
ucauacacau uuuaccagug                                                   20


<210>  15885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15885
gugaagcaag ccuagcuggg                                                   20


<210>  15886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15886
cugcauccuc cucuguaaaa                                                   20


<210>  15887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15887
gcugagcagu ucaggguucu                                                   20


<210>  15888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15888
accaugaggu cggcugagca                                                   20


<210>  15889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15889
ccacaggagc ccugcccaca                                                   20


<210>  15890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15890
caugugggca gggcuccugu                                                   20


<210>  15891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15891
uguuucagaa gaugugccaa                                                   20


<210>  15892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15892
aaaccuguag ugcuacuugc                                                   20


<210>  15893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15893
aguggcucug ucuuuaauau                                                   20


<210>  15894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15894
uuaauaucua uaagagcaca                                                   20


<210>  15895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15895
caggaagcca ugguccuuug                                                   20


<210>  15896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15896
uuugggggaa augaagaaca                                                   20


<210>  15897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15897
guacuugcaa aaggccuuuc                                                   20


<210>  15898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15898
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  15899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15899
cacaugccug uaaucccagc                                                   20


<210>  15900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15900
ggcuggucuc aaacucuuga                                                   20


<210>  15901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15901
caaacucuug accucaggug                                                   20


<210>  15902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15902
agaguuugag accagccuga                                                   20


<210>  15903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15903
guaauuccag cacuuuggga                                                   20


<210>  15904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15904
uaaauuuuua ugugagauga                                                   20


<210>  15905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15905
ggccuuuccu cccugaagcu                                                   20


<210>  15906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15906
uggaaaacug agagguuugc                                                   20


<210>  15907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15907
ugaguugcau uguuacaaca                                                   20


<210>  15908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15908
cuccaaauga gcuuacaguu                                                   20


<210>  15909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15909
gggaguaggu aaacagugug                                                   20


<210>  15910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15910
gcucccuccu ggcucuccuc                                                   20


<210>  15911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15911
cagccuaaua aaacugcaca                                                   20


<210>  15912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15912
gugcaguuuu auuaggcuga                                                   20


<210>  15913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15913
ugucacccag aaacuaugug                                                   20


<210>  15914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15914
cccagaaacu augugaccag                                                   20


<210>  15915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15915
cauaguuucu gggugacagg                                                   20


<210>  15916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15916
cgagugggua aaaugagcug                                                   20


<210>  15917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15917
gucuggggcu cccagaagac                                                   20


<210>  15918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15918
ggggcuccca gaagacacag                                                   20


<210>  15919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15919
ucugggagcc ccagacagac                                                   20


<210>  15920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15920
ggcugugucu ucugggagcc                                                   20


<210>  15921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15921
aaacaccucc uugucuuuua                                                   20


<210>  15922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15922
uuuaaggccu gggcugucua                                                   20


<210>  15923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15923
agggggaugg cuacuggcuu                                                   20


<210>  15924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15924
gucaucuuaa uacacacgga                                                   20


<210>  15925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15925
ucuuaauaca cacggaaugu                                                   20


<210>  15926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15926
guguggaagg gacagaccca                                                   20


<210>  15927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15927
cuuccacaca gacaccuuca                                                   20


<210>  15928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15928
gucccuucca cacagacacc                                                   20


<210>  15929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15929
uggcaauggg agcaggaaug                                                   20


<210>  15930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15930
accuucucua aaccugguca                                                   20


<210>  15931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15931
cuccuagucc caagauggag                                                   20


<210>  15932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15932
caagauggag aagccacauc                                                   20


<210>  15933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15933
gagccuccug aggcugcaga                                                   20


<210>  15934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15934
aaccaggaga cccaagacag                                                   20


<210>  15935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15935
ccugguugga ccccauucug                                                   20


<210>  15936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15936
ugggucuccu gguuggaccc                                                   20


<210>  15937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15937
caaugccugg agaagugagg                                                   20


<210>  15938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15938
aggcugcggu ggguggcaug                                                   20


<210>  15939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15939
ggcuccugga augccugucc                                                   20


<210>  15940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15940
cuggaagaca guaggcuauu                                                   20


<210>  15941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15941
uccagggaca ugucuggcuc                                                   20


<210>  15942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15942
agagaaaauu guugcagugc                                                   20


<210>  15943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15943
gagugcagac caagcuccca                                                   20


<210>  15944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15944
gcacucagac cugagcgcca                                                   20


<210>  15945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15945
uggguaggaa cugcugggug                                                   20


<210>  15946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15946
cauuucccug gcagcuauag                                                   20


<210>  15947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15947
ucacaaaaug ucacauuucc                                                   20


<210>  15948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15948
cuugcagugg gcuuuagggu                                                   20


<210>  15949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15949
gagcuuuauu auuuuaauaa                                                   20


<210>  15950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15950
uucauucccu cucugccccc                                                   20


<210>  15951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15951
gcugaguggu acucuucaga                                                   20


<210>  15952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15952
ugggggcagu gucggcugag                                                   20


<210>  15953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15953
ccucuuugac ucacacuugc                                                   20


<210>  15954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15954
aagaggagac cagggcccua                                                   20


<210>  15955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15955
ugccaggcaa gugugaguca                                                   20


<210>  15956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15956
gccugggucc acccuuccuu                                                   20


<210>  15957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15957
acccuuccuu ucuuagucac                                                   20


<210>  15958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15958
cugcaagauu ucacccagcc                                                   20


<210>  15959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15959
uauccuagca uucagauagg                                                   20


<210>  15960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15960
accucugacu acuucugguu                                                   20


<210>  15961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15961
gagguugacu uuuuuguucu                                                   20


<210>  15962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15962
cgaugcugag cucccacuuc                                                   20


<210>  15963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15963
gcugaaacag ccaacucugu                                                   20


<210>  15964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15964
cugucucccc caagcccucc                                                   20


<210>  15965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15965
cccccaagcc cuccuaguca                                                   20


<210>  15966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15966
gaacguucuc ucagcauuuc                                                   20


<210>  15967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15967
cuaagcacca guagaaagcu                                                   20


<210>  15968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15968
ugaaauuaua uagagaggug                                                   20


<210>  15969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15969
cugaaaaugc uuaaaagauc                                                   20


<210>  15970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15970
ccccaaaaaa acagccuucu                                                   20


<210>  15971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15971
accccacgcu uccacagccu                                                   20


<210>  15972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15972
accccugcgg cugcaugaga                                                   20


<210>  15973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15973
caugcagccg cagggguaga                                                   20


<210>  15974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15974
ggucucaugc agccgcaggg                                                   20


<210>  15975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15975
caauuugaca auacuccuca                                                   20


<210>  15976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15976
aauugagacu caccucauga                                                   20


<210>  15977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15977
auugugcugu uaguaaugag                                                   20


<210>  15978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15978
cuucuuuucu cuccgauccu                                                   20


<210>  15979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15979
uuuggcaccc cauucuucca                                                   20


<210>  15980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15980
ggacuuguag gugaaaugug                                                   20


<210>  15981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15981
ugacaaagug guguguucuu                                                   20


<210>  15982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15982
gcuuggggaa aaucacucau                                                   20


<210>  15983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15983
gccgagugag gcugccuuca                                                   20


<210>  15984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15984
agcugaaggc agccucacuc                                                   20


<210>  15985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15985
uucccuuagg ggccaaacca                                                   20


<210>  15986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15986
aacccagugg gccucucucc                                                   20


<210>  15987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15987
gugcccugaa caacagcuua                                                   20


<210>  15988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15988
uuauuuccua acucucuugc                                                   20


<210>  15989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15989
ccugcuuccg ggagguggga                                                   20


<210>  15990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15990
cagaguggcc agcugugucc                                                   20


<210>  15991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15991
aucauuuuag aauaaaucau                                                   20


<210>  15992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15992
gccacgaaug auuuauucua                                                   20


<210>  15993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15993
gccagaugcu guggagaugg                                                   20


<210>  15994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15994
cauacccugc aaagcccuau                                                   20


<210>  15995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15995
aaggauggcu gggaaagggg                                                   20


<210>  15996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15996
gaaagaacac cugggcccaa                                                   20


<210>  15997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15997
uguuagccaa augccagcac                                                   20


<210>  15998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15998
ccuucacagg ccagcugugg                                                   20


<210>  15999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  15999
gacuugccac aucuaaugcc                                                   20


<210>  16000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16000
gaccacagcu ggccugugaa                                                   20


<210>  16001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16001
gucaaacccc uggaaaacuu                                                   20


<210>  16002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16002
aaccccugga aaacuucaga                                                   20


<210>  16003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16003
gaaguuuucc agggguuuga                                                   20


<210>  16004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16004
uggaucugag gaacacuguc                                                   20


<210>  16005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16005
ugagccagcu cuguccugga                                                   20


<210>  16006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16006
acccgagcgc accaguccuc                                                   20


<210>  16007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16007
ucagacccuc caaggugaca                                                   20


<210>  16008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16008
gaggacuggu gcgcucgggu                                                   20


<210>  16009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16009
ccuuggaggg ucugaggacu                                                   20


<210>  16010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16010
uugucaccuu ggagggucug                                                   20


<210>  16011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16011
agugaggucu uugucaccuu                                                   20


<210>  16012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16012
aggaaagccc uggcuauaca                                                   20


<210>  16013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16013
uuuucuuagu gagcugccuu                                                   20


<210>  16014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16014
ccuaaauggc gaaggcagca                                                   20


<210>  16015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16015
ucagugguaa augcugccuu                                                   20


<210>  16016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16016
gcaaccucaa auaaugucua                                                   20


<210>  16017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16017
auaaugcuga gauuuauaca                                                   20


<210>  16018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16018
ggguguuaaa aggcacaugc                                                   20


<210>  16019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16019
uugaccuuag ucauaaacaa                                                   20


<210>  16020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16020
aagacaguau uucagaacaa                                                   20


<210>  16021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16021
uaaacaagca cuauuaaaaa                                                   20


<210>  16022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16022
guugggauau uauguuuuuu                                                   20


<210>  16023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16023
ugcuuugcau ucugcagagc                                                   20


<210>  16024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16024
aaaaccuaca aagacuauug                                                   20


<210>  16025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16025
uuguagguuu uggacacagu                                                   20


<210>  16026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16026
acaagagcac aauagucuuu                                                   20


<210>  16027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16027
cucaagaaau gaggacaggc                                                   20


<210>  16028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16028
ucauuucuug agagacucca                                                   20


<210>  16029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16029
cuuacacagg gcugccuccg                                                   20


<210>  16030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16030
uaagucggcu acugcuucua                                                   20


<210>  16031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16031
gcuacugcuu cuaagucccc                                                   20


<210>  16032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16032
ccagcuuuuc uaagacauau                                                   20


<210>  16033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16033
uagaaaagcu ggggacuuag                                                   20


<210>  16034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16034
uccaaacagc acaagacaga                                                   20


<210>  16035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16035
ugugcuguuu ggaagacaau                                                   20


<210>  16036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16036
ccccccaccc cacccgcuuu                                                   20


<210>  16037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16037
uguauacagu uucaacagcu                                                   20


<210>  16038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16038
ucacaguaau ccaaugcucc                                                   20


<210>  16039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16039
uuuguuacag gagcauugga                                                   20


<210>  16040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16040
uuugugaauu uuuuuuuguu                                                   20


<210>  16041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16041
ucgguguugg uuccuauggg                                                   20


<210>  16042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16042
ugcucaguua gggcauuauc                                                   20


<210>  16043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16043
uggugcuuac ugcccuuucu                                                   20


<210>  16044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16044
gaauuuuagg uugguucuuu                                                   20


<210>  16045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16045
acccccaccc ccaaacaaca                                                   20


<210>  16046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16046
ugaaccaagu guggaugagu                                                   20


<210>  16047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16047
ccucuuucac aucaggccuu                                                   20


<210>  16048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16048
cugagucuga cuuuuaccca                                                   20


<210>  16049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16049
gacuuuuacc caaacagggg                                                   20


<210>  16050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16050
gacucaggga cccggcugca                                                   20


<210>  16051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16051
cgcagcaacu ggcaaccccc                                                   20


<210>  16052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16052
agugcaguuc cacacugugc                                                   20


<210>  16053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16053
ucuucagaac aggaaaaguc                                                   20


<210>  16054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16054
uuugccugcc aaaugcuuua                                                   20


<210>  16055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16055
auucuccuag caacgcuucu                                                   20


<210>  16056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16056
ccuuggcgac agggcuggac                                                   20


<210>  16057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16057
ccaaggagac ccucagggaa                                                   20


<210>  16058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16058
agcccugucg ccaaggagac                                                   20


<210>  16059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16059
aggcugccag ugcaaagguc                                                   20


<210>  16060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16060
ccucuauggu gcuggcuuug                                                   20


<210>  16061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16061
uuugaauccu gaggaccaag                                                   20


<210>  16062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16062
ucaggauuca aaagacaccu                                                   20


<210>  16063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16063
uaggagagcu ccuugguccu                                                   20


<210>  16064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16064
cugguucuuc ugugauugcu                                                   20


<210>  16065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16065
ucuaggcuuu agcaaucaca                                                   20


<210>  16066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16066
gagccacuuu ucuuuggagg                                                   20


<210>  16067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16067
guguuucugu cugagccacu                                                   20


<210>  16068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16068
gaugagaaau aagagucagu                                                   20


<210>  16069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16069
aaagauucaa gcugagaaac                                                   20


<210>  16070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16070
cagcuuuggc uggcuuggau                                                   20


<210>  16071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16071
ucuuuuccac agguucuccu                                                   20


<210>  16072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16072
acgguuagcc ccuggcuugg                                                   20


<210>  16073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16073
guguggcucu gcugugcuca                                                   20


<210>  16074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16074
cagaaaacgg uucuguggaa                                                   20


<210>  16075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16075
ugugcuucca cagaaccguu                                                   20


<210>  16076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16076
ugagaagucc aggaaaagau                                                   20


<210>  16077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16077
aggaaaagau gcagcuucca                                                   20


<210>  16078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16078
accugagacc ugagaaaaca                                                   20


<210>  16079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16079
cagguagacc aucgagcugc                                                   20


<210>  16080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16080
uugguagcua aagaacaaca                                                   20


<210>  16081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16081
aguucuuugg ggagggccag                                                   20


<210>  16082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16082
acuggggcuc uccgaacagc                                                   20


<210>  16083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16083
agcauccacu gaaguccuga                                                   20


<210>  16084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16084
ugaaguggug aaggagcccc                                                   20


<210>  16085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16085
ggggcuccuu caccacuuca                                                   20


<210>  16086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16086
ccgagccaca cauuuugggg                                                   20


<210>  16087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16087
aucuugacuc cucccuuccu                                                   20


<210>  16088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16088
agauggaccc caaaaugugu                                                   20


<210>  16089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16089
gcaaauccug ccgguuuucc                                                   20


<210>  16090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16090
agaauccagc cccuucucac                                                   20


<210>  16091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16091
ccaccacccu gguccacgcc                                                   20


<210>  16092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16092
acgccaccau cacuugccua                                                   20


<210>  16093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16093
gaaggcaaau uuuaggcaag                                                   20


<210>  16094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16094
caaaaugcgg cccaagagac                                                   20


<210>  16095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16095
cuugggccgc auuuugagac                                                   20


<210>  16096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16096
uaugacauca cuccuccagu                                                   20


<210>  16097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16097
uaugacuugc gcuuccagag                                                   20


<210>  16098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16098
gagccaaaaa ucccugcucu                                                   20


<210>  16099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16099
uucaaggagc cagcuggucu                                                   20


<210>  16100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16100
ccucuccucc uccuccugca                                                   20


<210>  16101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16101
gaguggaaag agugcaggag                                                   20


<210>  16102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16102
cugcucucua cacacucuuc                                                   20


<210>  16103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16103
ccaugcaccc cuuaccccuc                                                   20


<210>  16104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16104
cuccccagcu agaaaggggg                                                   20


<210>  16105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16105
ggcagcccaa ccugggggca                                                   20


<210>  16106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16106
cagggccugu ggggaaaaug                                                   20


<210>  16107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16107
aggguucccc caaaccagcu                                                   20


<210>  16108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16108
uuccuaaggc uuagguggag                                                   20


<210>  16109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16109
cuuugccaug gccuccuucu                                                   20


<210>  16110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16110
aauuguaugc uaggguggga                                                   20


<210>  16111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16111
gaauuaaaag aacucgccaa                                                   20


<210>  16112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16112
uucuauguga cuccacucuu                                                   20


<210>  16113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16113
cauagaauga cauuacuucc                                                   20


<210>  16114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16114
gcaugaauag caucuuuaag                                                   20


<210>  16115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16115
gaaaucagag ggaaauauua                                                   20


<210>  16116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16116
ucaguuuuga aucagauuag                                                   20


<210>  16117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16117
uuaauagugc aguuauguag                                                   20


<210>  16118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16118
acguauuuuc caagccacag                                                   20


<210>  16119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16119
uguaagacac uaaggggcag                                                   20


<210>  16120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16120
uacaugacua gcugcuucuu                                                   20


<210>  16121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16121
uuaauucuuc uccaagcuuu                                                   20


<210>  16122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16122
uuggccgagc aaguauuacg                                                   20


<210>  16123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16123
cagucacucc aaaaugaaua                                                   20


<210>  16124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16124
cuccaaaaug aauaugugug                                                   20


<210>  16125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16125
gagaggaagc cugcuuuccu                                                   20


<210>  16126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16126
cuguggaacu gcucauggug                                                   20


<210>  16127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16127
cuucaccucc cuuggccugu                                                   20


<210>  16128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16128
uugagcuuuc cuggcugcac                                                   20


<210>  16129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16129
ccuucuaccu gccccugugc                                                   20


<210>  16130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16130
cacuuuuuac aauuuagcau                                                   20


<210>  16131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16131
aaagaaaacu gaagccccca                                                   20


<210>  16132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16132
ccagauuaug aaccaacuuc                                                   20


<210>  16133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16133
ucauaaggcu gugaacgucg                                                   20


<210>  16134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16134
caaguaugag ucaccucuga                                                   20


<210>  16135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16135
ccucugauga cggauaggag                                                   20


<210>  16136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16136
ucagagguga cucauacuug                                                   20


<210>  16137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16137
ccuccaaaug gaugccaugu                                                   20


<210>  16138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16138
aagaggugaa acuccuuucu                                                   20


<210>  16139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16139
cagagauuaa cauuuucuca                                                   20


<210>  16140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16140
gcuguugcuc uguguguuca                                                   20


<210>  16141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16141
caguggacca caccaccacc                                                   20


<210>  16142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16142
acugugacuc gucagcuguu                                                   20


<210>  16143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16143
uuucucugcc uuucucaggg                                                   20


<210>  16144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16144
ccauuugagg agagguucag                                                   20


<210>  16145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16145
ucaugauccc ugaaccucuc                                                   20


<210>  16146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16146
agccugugag ggguuggggg                                                   20


<210>  16147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16147
ggaugacucu cacuagguuu                                                   20


<210>  16148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16148
uccugacucu ggggaagagc                                                   20


<210>  16149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16149
ggggcaugau ggggauguac                                                   20


<210>  16150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16150
cugcagcuga cacggcucca                                                   20


<210>  16151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16151
gcugcagaga cuggaguccg                                                   20


<210>  16152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16152
cauauuuagc aucuuggagc                                                   20


<210>  16153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16153
ccuccuuguc ucauauuuag                                                   20


<210>  16154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16154
caggaguggc acuagaagga                                                   20


<210>  16155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16155
cugcucccuc aggagccauc                                                   20


<210>  16156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16156
acagcagaaa ccagcgccca                                                   20


<210>  16157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16157
ugucuggauc uucccagucc                                                   20


<210>  16158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16158
ggaucuuccc aguccugccc                                                   20


<210>  16159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16159
ugcccucucu cuucugaauc                                                   20


<210>  16160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16160
gugcuguugg guuuauucau                                                   20


<210>  16161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16161
ugaucaggga ugaguccgug                                                   20


<210>  16162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16162
uagcucuagc acugggcaca                                                   20


<210>  16163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16163
gcaccuacga aggguccuau                                                   20


<210>  16164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16164
uaugcaguga acaccuugca                                                   20


<210>  16165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16165
gaagggcaga cucucucuuc                                                   20


<210>  16166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16166
gcccuucaga cugcaaggug                                                   20


<210>  16167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16167
ggaaggcaga gaaucucugg                                                   20


<210>  16168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16168
agaccuggau ucuaguucca                                                   20


<210>  16169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16169
cgacucaauc cagggaguuu                                                   20


<210>  16170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16170
uaaauccuca gagaaggaca                                                   20


<210>  16171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16171
uucucugagg auuuaggacu                                                   20


<210>  16172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16172
guccuucucu gaggauuuag                                                   20


<210>  16173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16173
gcccucaagu cuguccuucu                                                   20


<210>  16174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16174
uugugugcug ccucagccca                                                   20


<210>  16175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16175
acaaggagau ggcuggugug                                                   20


<210>  16176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16176
caagacuugg agaacaagcc                                                   20


<210>  16177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16177
ugggacugcc cagaaauggg                                                   20


<210>  16178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16178
ccugagguca ggaguucaag                                                   20


<210>  16179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16179
ggaguucaag accagccuag                                                   20


<210>  16180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16180
ugaacuccug accucaggug                                                   20


<210>  16181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16181
cccaggcugg agugcagugc                                                   20


<210>  16182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16182
cgcucugucg cccaggcugg                                                   20


<210>  16183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16183
gacugucuuu acaacacaau                                                   20


<210>  16184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16184
gaccaacuag auuuauuugc                                                   20


<210>  16185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16185
uuacaacaca augaaagggu                                                   20


<210>  16186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16186
ugcauacaca uacacuaaaa                                                   20


<210>  16187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16187
cucuuuucuu uuuuuuuuuu                                                   20


<210>  16188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16188
aagccaccca aaggaaagca                                                   20


<210>  16189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16189
cuuccgaacu cagccguucu                                                   20


<210>  16190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16190
caccagaggg agaacggcug                                                   20


<210>  16191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16191
ccuggaggug ugggaagcug                                                   20


<210>  16192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16192
gggcaacacu uuggaguuag                                                   20


<210>  16193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16193
cgcucaccug gaagccagug                                                   20


<210>  16194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16194
agcagugaac ucugcuugca                                                   20


<210>  16195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16195
uuguggcuuu caccccaugg                                                   20


<210>  16196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16196
agggaaggug ugaggcuggg                                                   20


<210>  16197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16197
uucucuguuc aaucaagcag                                                   20


<210>  16198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16198
uguuuuauuu uuugugccuu                                                   20


<210>  16199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16199
cucugggauu aguuaaaagg                                                   20


<210>  16200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16200
gcaacuuggc uuucuuugga                                                   20


<210>  16201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16201
ggccuuccua guuaccuaga                                                   20


<210>  16202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16202
agcccacuag aaggagauac                                                   20


<210>  16203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16203
cacagauauu uauggagggc                                                   20


<210>  16204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16204
gccacccacc accacuuucu                                                   20


<210>  16205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16205
acucacaucu cuguccgcca                                                   20


<210>  16206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16206
guccacucac aucucugucc                                                   20


<210>  16207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16207
gugucagucc acucacaucu                                                   20


<210>  16208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16208
uuuggaagcc cccaugucug                                                   20


<210>  16209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16209
ggggcagaaa uggggaagcu                                                   20


<210>  16210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16210
uacugugggg auuaccgagu                                                   20


<210>  16211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16211
ccaccaggcu gcgcugaaca                                                   20


<210>  16212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16212
auucgagaaa gauccaauaa                                                   20


<210>  16213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16213
uggaauacaa auacccugga                                                   20


<210>  16214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16214
gaagggcggu ggccccucuu                                                   20


<210>  16215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16215
ucauugaacu ggguuaugaa                                                   20


<210>  16216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16216
ucacaggcuu auggccacaa                                                   20


<210>  16217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16217
guaaugcuuu ucauaucauc                                                   20


<210>  16218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16218
ccucuccuca ccccagcaca                                                   20


<210>  16219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16219
uuguguuuaa uaguacaaca                                                   20


<210>  16220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16220
uuuuugaguu uccagcaaaa                                                   20


<210>  16221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16221
gugcaaaguu augaacagcu                                                   20


<210>  16222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16222
ucacugggag aggagccaag                                                   20


<210>  16223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16223
cugggagagg agccaagagg                                                   20


<210>  16224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16224
ccuaaggugc ccccucccuc                                                   20


<210>  16225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16225
uccggggaag uggagaggaa                                                   20


<210>  16226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16226
gggaacucgu gucaggagug                                                   20


<210>  16227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16227
ggaguggaga gcuaagcuca                                                   20


<210>  16228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16228
auauugagcu uagcucucca                                                   20


<210>  16229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16229
uuguccauau ugagcuuagc                                                   20


<210>  16230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16230
ugaugccaca uuucucccau                                                   20


<210>  16231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16231
gccaucuuug agggcaguua                                                   20


<210>  16232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16232
acuaggaaug cuagaucuuu                                                   20


<210>  16233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16233
ucaaugaagc acugguuuuu                                                   20


<210>  16234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16234
ugcuugcuuu uuuaaaaacc                                                   20


<210>  16235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16235
gcacucuuau guccugcuug                                                   20


<210>  16236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16236
uaugucugca cucuuauguc                                                   20


<210>  16237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16237
aauggcaaga uaucuuagug                                                   20


<210>  16238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16238
gauaacuaca gaguccaaug                                                   20


<210>  16239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16239
ucucuggaau gaagaggaaa                                                   20


<210>  16240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16240
cuggaaugaa gaggaaaugg                                                   20


<210>  16241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16241
accuucgauc ccuuaugcuu                                                   20


<210>  16242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16242
uuaaaaauag aacuagggug                                                   20


<210>  16243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16243
uccuaccacc uuuccugcua                                                   20


<210>  16244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16244
uuugcccuuu cuucuugccu                                                   20


<210>  16245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16245
gccaggaaug aaagugggaa                                                   20


<210>  16246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16246
accacugccu agcaaguaga                                                   20


<210>  16247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16247
acuugcuagg cagugguaga                                                   20


<210>  16248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16248
uuuuacagau gagaaagguu                                                   20


<210>  16249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16249
uaucauuaac ccugucauuu                                                   20


<210>  16250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16250
augucuacau agaagaugcu                                                   20


<210>  16251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16251
acauagaaga ugcucaauaa                                                   20


<210>  16252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16252
acuagaggaa caagaaccuu                                                   20


<210>  16253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16253
acaagaguuu cugaggaauc                                                   20


<210>  16254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16254
uuuaaaaauu uucucuccuc                                                   20


<210>  16255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16255
ugaacuccua gcuucaagca                                                   20


<210>  16256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16256
cuacaaaaag cuuaauaaau                                                   20


<210>  16257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16257
agguuugaua gauaaaaaac                                                   20


<210>  16258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16258
cauucccucu gucaacaucu                                                   20


<210>  16259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16259
acaucugcug agcucucaua                                                   20


<210>  16260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16260
caggauuaga ccuaccguuc                                                   20


<210>  16261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16261
aauccuguga cuccuuuauc                                                   20


<210>  16262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16262
ugaagcagac ucagagaauu                                                   20


<210>  16263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16263
gcuucaugac aggcuguaac                                                   20


<210>  16264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16264
gcgauagagc agauucagga                                                   20


<210>  16265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16265
ucuuacaggc auaauccuga                                                   20


<210>  16266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16266
cuucugcuca cucuuuauuc                                                   20


<210>  16267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16267
ccccaugccu uugcgugugg                                                   20


<210>  16268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16268
ccucccaugc ccucucuggu                                                   20


<210>  16269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16269
auccagaauc agaacguggg                                                   20


<210>  16270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16270
uuaaaaucca cgcccggccc                                                   20


<210>  16271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16271
agcuggaugg acaccaucca                                                   20


<210>  16272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16272
auccagcuug accugaacuu                                                   20


<210>  16273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16273
uucaccacca gccguauuuc                                                   20


<210>  16274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16274
guaacaagca gccccaggaa                                                   20


<210>  16275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16275
uucaaggugg guccugaagc                                                   20


<210>  16276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16276
ugaagccaca guaagcacca                                                   20


<210>  16277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16277
auuuucucuc aagaguugag                                                   20


<210>  16278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16278
cugguaggua cuaccaaacc                                                   20


<210>  16279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16279
ucagguuccc uuucuugccc                                                   20


<210>  16280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16280
auggguauca acaccuuuaa                                                   20


<210>  16281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16281
uuuugauucu auaaccucca                                                   20


<210>  16282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16282
cucaauaugg agguuauaga                                                   20


<210>  16283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16283
ggugcugggc ccugaacuau                                                   20


<210>  16284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16284
guacaucagc uuuuuaauga                                                   20


<210>  16285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16285
auaaccugua aggagagaug                                                   20


<210>  16286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16286
ccuuuuuccu acgauguucc                                                   20


<210>  16287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16287
ucacuugccu gccugccugc                                                   20


<210>  16288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16288
gauuucagga gcgauuucuc                                                   20


<210>  16289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16289
acuuacugcu guugcaaagc                                                   20


<210>  16290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16290
gaacagaacu ggccucagaa                                                   20


<210>  16291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16291
caugcccacg ugaauuccua                                                   20


<210>  16292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16292
cauccuguau ucuccuaaau                                                   20


<210>  16293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16293
uuggaguaau uuaggagaau                                                   20


<210>  16294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16294
ucacugaguu uucuuuguca                                                   20


<210>  16295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16295
uuugccaauc cauaacucag                                                   20


<210>  16296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16296
agagagaauu auccaagcau                                                   20


<210>  16297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16297
cuggcaagca auuauuguau                                                   20


<210>  16298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16298
ugaaaaaaaa agugaaaugu                                                   20


<210>  16299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16299
gaggaccuga aaucaagugc                                                   20


<210>  16300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16300
ucagacucca gaauuuauac                                                   20


<210>  16301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16301
gagcaaaaca guuuacauca                                                   20


<210>  16302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16302
uaaauucaua ggcacaacca                                                   20


<210>  16303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16303
gcucuuuuug augcaaauau                                                   20


<210>  16304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16304
cccaccccca ccccauguug                                                   20


<210>  16305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16305
ccuacggaau cuacaggaau                                                   20


<210>  16306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16306
ggcugccccu ucagauuccu                                                   20


<210>  16307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16307
acccagcaug auaaaaccaa                                                   20


<210>  16308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16308
gggaaacuau uugucuaaac                                                   20


<210>  16309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16309
aaacacuuuu uggaaaggga                                                   20


<210>  16310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16310
gcacacacac acacacacac                                                   20


<210>  16311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16311
acugccagug aagccaaacc                                                   20


<210>  16312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16312
cucaguuauc ugagaguggc                                                   20


<210>  16313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16313
gcucucucuc gcuucacaca                                                   20


<210>  16314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16314
cucugguuuu acaaaauguc                                                   20


<210>  16315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16315
gggaauggug ugaugugguu                                                   20


<210>  16316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16316
cagcuuccag gcagcagaua                                                   20


<210>  16317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16317
cugccguauc ugcugccugg                                                   20


<210>  16318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16318
caggggagcc auggugggcc                                                   20


<210>  16319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16319
cuggugggcu ucgugcagcc                                                   20


<210>  16320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16320
cacagcgaca guccuggcuu                                                   20


<210>  16321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16321
cugugugacu ugaaagcuag                                                   20


<210>  16322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16322
uggcuuuugc uaucuagaag                                                   20


<210>  16323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16323
ucccuuaaag ggaaggcugc                                                   20


<210>  16324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16324
aggguuaagc agccuucccu                                                   20


<210>  16325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16325
ccuucuuucu gagagugugg                                                   20


<210>  16326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16326
aucuccucuc aggcaaauca                                                   20


<210>  16327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16327
caaagccuug ucuucauaac                                                   20


<210>  16328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16328
ucauaacacu accagccacg                                                   20


<210>  16329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16329
cagcugcuuc uuccugaccc                                                   20


<210>  16330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16330
ggaagaagca gcugggacgu                                                   20


<210>  16331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16331
gauguggcgu uugcuugagu                                                   20


<210>  16332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16332
uuuucagugc augaggcaga                                                   20


<210>  16333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16333
cccauucucc uggaagaaca                                                   20


<210>  16334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16334
guacugugca cuguccccca                                                   20


<210>  16335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16335
uuuaaggguc uguacugugc                                                   20


<210>  16336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16336
uguaucuggg aaguucauug                                                   20


<210>  16337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16337
uaugggcaag aaaguaccug                                                   20


<210>  16338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16338
ccuugcuacc ucugagccaa                                                   20


<210>  16339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16339
guguuguuuc uucaccaagg                                                   20


<210>  16340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16340
ggcaauaccu uuauuuucug                                                   20


<210>  16341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16341
ccaaguccac aucuuccagc                                                   20


<210>  16342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16342
acaucuucca gcuccaacca                                                   20


<210>  16343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16343
uucuugucuu cuguaacccu                                                   20


<210>  16344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16344
ucuguaaccc uaucgccucc                                                   20


<210>  16345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16345
gggaucaacu uaaauaauaa                                                   20


<210>  16346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16346
uaucauuuca ucaguaaaca                                                   20


<210>  16347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16347
caaauaaagu cccguauuac                                                   20


<210>  16348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16348
cguauuacca aauaggggag                                                   20


<210>  16349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16349
uguuuuggag gaucccuucc                                                   20


<210>  16350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16350
ugaaccucac uggaagggau                                                   20


<210>  16351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16351
gcccaagcuc cugccccuug                                                   20


<210>  16352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16352
uuugcccugu ucagggcuga                                                   20


<210>  16353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16353
cugugacagu ccucccacau                                                   20


<210>  16354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16354
cagagacucu cagagggugc                                                   20


<210>  16355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16355
ucccacaucg acugccccac                                                   20


<210>  16356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16356
augugggagg acugucacag                                                   20


<210>  16357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16357
cccucacucc ccaccaugug                                                   20


<210>  16358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16358
gaugugguga ugggccacau                                                   20


<210>  16359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16359
uggaagaaag uguucuccug                                                   20


<210>  16360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16360
aggagaacac uuucuuccaa                                                   20


<210>  16361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16361
uggauauaca gcugacuaga                                                   20


<210>  16362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16362
gcuguauauc caagacaugc                                                   20


<210>  16363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16363
guuauguucc aaauggguuu                                                   20


<210>  16364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16364
agguucugca ggcaagagca                                                   20


<210>  16365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16365
aaaaauagua uuugcucuug                                                   20


<210>  16366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16366
aaaugcuuuu agagacagug                                                   20


<210>  16367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16367
cuaaaagcau uuugaccuua                                                   20


<210>  16368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16368
acaauaaaac cuauugauca                                                   20


<210>  16369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16369
cucuggagca cuaguuccag                                                   20


<210>  16370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16370
acagagaaaa cggccaggca                                                   20


<210>  16371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16371
aacaagcuuu uacccacaga                                                   20


<210>  16372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16372
auuuaaccag augcagaggc                                                   20


<210>  16373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16373
cagaaaauac acucauggca                                                   20


<210>  16374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16374
ucucaacuca ggggaggcac                                                   20


<210>  16375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16375
uuugugccuc cccugaguug                                                   20


<210>  16376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16376
caagcaggaa uccuggaugg                                                   20


<210>  16377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16377
guuguucaca uagcgcugga                                                   20


<210>  16378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16378
gauuuugaug aaaagugguu                                                   20


<210>  16379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16379
uuagaauuca ccaugauucc                                                   20


<210>  16380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16380
ucauaagaua aagcauauau                                                   20


<210>  16381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16381
ugugugguac accuauaaaa                                                   20


<210>  16382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16382
cuggaaaauu acuuaacuag                                                   20


<210>  16383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16383
auucuugaac guuugggcua                                                   20


<210>  16384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16384
gugcuuaaag cuccuauuug                                                   20


<210>  16385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16385
auuacauuaa ugucugugcu                                                   20


<210>  16386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16386
auuauguucc cauaaauacc                                                   20


<210>  16387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16387
cucaaacaau aaagcacccc                                                   20


<210>  16388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16388
ggagucucuc aaacaauaaa                                                   20


<210>  16389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16389
caaugugaua uauagauuau                                                   20


<210>  16390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16390
gcugugucac aaugugauau                                                   20


<210>  16391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16391
uggcucacua augcggucag                                                   20


<210>  16392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16392
uagcggcagc uuccuaucau                                                   20


<210>  16393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16393
gaauacauaa uuuugucacc                                                   20


<210>  16394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16394
ccuaucucug gcaugaaugu                                                   20


<210>  16395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16395
uacaaggaac acauauuuca                                                   20


<210>  16396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16396
agcaaauacc auuuauaugu                                                   20


<210>  16397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16397
cagaacaggc cauaugcuuu                                                   20


<210>  16398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16398
ucaacacuaa cagagggaga                                                   20


<210>  16399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16399
cuggaguuag gaauuuuugc                                                   20


<210>  16400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16400
auacagagaa accagcuuuu                                                   20


<210>  16401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16401
guuaauugaa uuuaaaauac                                                   20


<210>  16402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16402
uugcagguga gccccauuca                                                   20


<210>  16403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16403
gugguguuca uacuaugcua                                                   20


<210>  16404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16404
ccaugauguu cuagcauagu                                                   20


<210>  16405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16405
cuaagucccc augauguucu                                                   20


<210>  16406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16406
aaacuaucua uuuuaccuac                                                   20


<210>  16407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16407
uguaaaguag guaaaauaga                                                   20


<210>  16408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16408
gaacccaggu guccugguuu                                                   20


<210>  16409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16409
ugguuuucag aucagugucu                                                   20


<210>  16410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16410
cucuguuaac acuaaaaguc                                                   20


<210>  16411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16411
aaguuugguu cuggaaaauc                                                   20


<210>  16412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16412
uuugggcauu acagauuuuc                                                   20


<210>  16413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16413
ugguaauuuc uccauggcuu                                                   20


<210>  16414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16414
acuuggaagg ccuuuacuaa                                                   20


<210>  16415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16415
ucauacuaca ggcagauacu                                                   20


<210>  16416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16416
cuauacaucu aaucaauaaa                                                   20


<210>  16417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16417
uauuuauuua uugauuagau                                                   20


<210>  16418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16418
ccuaugcauc uccccccacc                                                   20


<210>  16419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16419
gcgaugcaga gggggugggg                                                   20


<210>  16420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16420
gcaaaauaaa aaugugucgg                                                   20


<210>  16421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16421
gguaauuaaa uggguauuua                                                   20


<210>  16422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16422
cugaugcaaa uuauuaaguu                                                   20


<210>  16423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16423
augucaggag gguguuaaag                                                   20


<210>  16424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16424
ggaggguguu aaagaagaag                                                   20


<210>  16425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16425
aacauuuuca uugcaucuuc                                                   20


<210>  16426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16426
uguaauuuau ggcugcuuuc                                                   20


<210>  16427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16427
ugaugaaaca aauaaagggc                                                   20


<210>  16428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16428
gcccuuuauu uguuucauca                                                   20


<210>  16429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16429
gauucauugu gacacacaca                                                   20


<210>  16430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16430
caaugaauca gacgcauuau                                                   20


<210>  16431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16431
acagcauuga uuuuuagucg                                                   20


<210>  16432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16432
acauuucaau cagguugaag                                                   20


<210>  16433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16433
acuaaaaauc aaugcuguug                                                   20


<210>  16434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16434
acugccccuc ugaggucucc                                                   20


<210>  16435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16435
ccccgguuau ggcuuugcua                                                   20


<210>  16436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16436
ccggccugcc ucuugggaca                                                   20


<210>  16437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16437
caagaggcag gccggugacc                                                   20


<210>  16438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16438
aggagaccca gcaaauaaaa                                                   20


<210>  16439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16439
ccuagacuga aaugauaaag                                                   20


<210>  16440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16440
cccuggaaga gaagcucuua                                                   20


<210>  16441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16441
agaguguagu gguucucccu                                                   20


<210>  16442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16442
cuacauaccc uugggucaag                                                   20


<210>  16443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16443
ugcaagcccu ucccccucac                                                   20


<210>  16444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16444
ucaauggagg ucaugcaagc                                                   20


<210>  16445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16445
augccccggg acagagugcg                                                   20


<210>  16446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16446
cggggcaugg acguccucaa                                                   20


<210>  16447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16447
agagcuccaa agcuucacuu                                                   20


<210>  16448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16448
ucugaguuug aggugggaug                                                   20


<210>  16449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16449
cauccagguu gucuucugag                                                   20


<210>  16450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16450
gucacaucca gguugucuuc                                                   20


<210>  16451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16451
uucugcuaga accaagggag                                                   20


<210>  16452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16452
auguuagccu ggccaauuug                                                   20


<210>  16453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16453
ugcuucagca aauauuaaua                                                   20


<210>  16454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16454
gggcagccug uggagugacu                                                   20


<210>  16455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16455
cuccacaggc ugcccugacg                                                   20


<210>  16456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16456
acagcuccau augauccgca                                                   20


<210>  16457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16457
ggaaggcaug cuggaaacuu                                                   20


<210>  16458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16458
uaaucugcuu cgaggagguu                                                   20


<210>  16459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16459
uaagaaacac cacugccacg                                                   20


<210>  16460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16460
cucccucccu guauaauucu                                                   20


<210>  16461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16461
cuguggcauu uacuucucgg                                                   20


<210>  16462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16462
gagcuuaguu ucucauucag                                                   20


<210>  16463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16463
ccugaccaag ccacacacaa                                                   20


<210>  16464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16464
ggagacugca gugggcugaa                                                   20


<210>  16465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16465
ugagaaacag agggaggagg                                                   20


<210>  16466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16466
agaaugagcc ugaaaucaag                                                   20


<210>  16467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16467
uuuccccauc uguccagaau                                                   20


<210>  16468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16468
aguuuuucaa ucuucuggga                                                   20


<210>  16469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16469
cucccauggg uucugugguc                                                   20


<210>  16470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16470
agcaccagag cuuccugccc                                                   20


<210>  16471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16471
acaguuguuc aauccuuugg                                                   20


<210>  16472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16472
uuuaacccuu gaugaacccc                                                   20


<210>  16473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16473
gacacauggu aauaaugaca                                                   20


<210>  16474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16474
gacacauuga uauuccaucc                                                   20


<210>  16475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16475
uuauuaccau gugucugaca                                                   20


<210>  16476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16476
gugcuuuccc ucauuuacuu                                                   20


<210>  16477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16477
augugagaag uaaaugaggg                                                   20


<210>  16478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16478
cuuaccucau agaguccaug                                                   20


<210>  16479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16479
gagggaauca uuucaccucu                                                   20


<210>  16480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16480
cacacccagg caggcacaag                                                   20


<210>  16481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16481
auggggagag gggacuccca                                                   20


<210>  16482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16482
ccucucccca uagacgugug                                                   20


<210>  16483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16483
cauuauguuu cugguggcag                                                   20


<210>  16484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16484
aaagagcuca gggucucauu                                                   20


<210>  16485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16485
caaaguaguu cccccauuau                                                   20


<210>  16486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16486
uaaccguaau aguaaugagc                                                   20


<210>  16487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16487
caaaagcuca uuacuauuac                                                   20


<210>  16488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16488
agggcauauu uccccucuuu                                                   20


<210>  16489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16489
cuccucccuu ucuuaccagc                                                   20


<210>  16490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16490
uuguaaccug agcugguaag                                                   20


<210>  16491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16491
ucucucccac cuagaugucu                                                   20


<210>  16492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16492
augaugggaa aaauauuuuu                                                   20


<210>  16493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16493
gaaaugauau ucacacaaua                                                   20


<210>  16494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16494
ccaaaccacu ugaaagcccu                                                   20


<210>  16495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16495
ccuagguggg auucuaugaa                                                   20


<210>  16496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16496
uugcccuccu gccacaagug                                                   20


<210>  16497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16497
ggaaguuauu gggaugauga                                                   20


<210>  16498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16498
ucaucccaau aacuuccuga                                                   20


<210>  16499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16499
caauaaacua aaaaacacag                                                   20


<210>  16500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16500
uggguccugc ccaggaaagg                                                   20


<210>  16501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16501
ugcccaggaa aggcugcgcc                                                   20


<210>  16502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16502
guggcugaga acgauaauau                                                   20


<210>  16503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16503
ccugaacaca accaaacccu                                                   20


<210>  16504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16504
uuuggcuaca uaugcggguu                                                   20


<210>  16505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16505
cuuuuuuuuu uuauuuuuua                                                   20


<210>  16506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16506
uuuggcuaaa ggcaaaaaaa                                                   20


<210>  16507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16507
gcagguauuu aaaaaagaaa                                                   20


<210>  16508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16508
gggccccagu gcagccaagc                                                   20


<210>  16509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16509
auuaacagau gaacuuggcc                                                   20


<210>  16510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16510
ucucuguucu ccuaccucuu                                                   20


<210>  16511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16511
aguuuuuagg agcucgaaag                                                   20


<210>  16512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16512
gcgcuuuucc cuuucuauuc                                                   20


<210>  16513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16513
cagggugcgc ccugaacuug                                                   20


<210>  16514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16514
ggggucccag ggugcgcccu                                                   20


<210>  16515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16515
gcuaaaccag ucuggcuaca                                                   20


<210>  16516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16516
ggcuacacca uggccaggga                                                   20


<210>  16517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16517
aucugcuccg gagaaggugg                                                   20


<210>  16518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16518
aguccaucug cuccggagaa                                                   20


<210>  16519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16519
agguuuuucu ccucccucug                                                   20


<210>  16520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16520
ggcaacacag agggaggaga                                                   20


<210>  16521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16521
ugcacacaca gacacaaauc                                                   20


<210>  16522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16522
gugugugcag gaccgucggg                                                   20


<210>  16523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16523
aacgggauuu gugucugugu                                                   20


<210>  16524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16524
aaaagauucu guggguccaa                                                   20


<210>  16525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16525
caguauuuaa uuuauuuucu                                                   20


<210>  16526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16526
ggguaaauua auggauauga                                                   20


<210>  16527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16527
aaugagagca aggucccucc                                                   20


<210>  16528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16528
cuccaaaaaa uauuaauaaa                                                   20


<210>  16529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16529
agccaaugaa acuugcucca                                                   20


<210>  16530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16530
ugccaaagug uauggagcaa                                                   20


<210>  16531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16531
gaguccugcc aaaguguaug                                                   20


<210>  16532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16532
gcacagggcc ccccaaugcc                                                   20


<210>  16533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16533
ccugguggug ucugcacagg                                                   20


<210>  16534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16534
gcgucuccug guggugucug                                                   20


<210>  16535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16535
auaacgucuu auucagccuu                                                   20


<210>  16536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16536
uauucagccu uuccaugugg                                                   20


<210>  16537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16537
ggaaguuacc cacaggcugc                                                   20


<210>  16538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16538
guguccaccc ugccccucaa                                                   20


<210>  16539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16539
acccugcccc ucaaaggaca                                                   20


<210>  16540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16540
uuugaggggc aggguggaca                                                   20


<210>  16541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16541
gggggauuuc auuuguccuu                                                   20


<210>  16542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16542
ugaguucuuc auuuaggugg                                                   20


<210>  16543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16543
ccacaacacu cagccucacg                                                   20


<210>  16544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16544
uugugccuug aaaugcaaaa                                                   20


<210>  16545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16545
aucucacugg uggucuauua                                                   20


<210>  16546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16546
auuaauaguu ugaaguuuug                                                   20


<210>  16547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16547
gaaggugguu guugcuuuuu                                                   20


<210>  16548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16548
uuuccaguuu uuuaaaaagg                                                   20


<210>  16549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16549
uucugaagaa acauuaacgc                                                   20


<210>  16550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16550
uaauaaugaa caacacauga                                                   20


<210>  16551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16551
uuugaaaaug uauuuucagg                                                   20


<210>  16552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16552
caccaccaaa auuuaauggu                                                   20


<210>  16553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16553
ccauuaaauu uugguggugg                                                   20


<210>  16554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16554
aguacacaaa uaauucuaca                                                   20


<210>  16555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16555
cuuuugacuu accauuaugu                                                   20


<210>  16556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16556
aaagugacug gaaacuucug                                                   20


<210>  16557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16557
guguuuacau uccuggaagu                                                   20


<210>  16558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16558
guuuauuuaa cuuccaggaa                                                   20


<210>  16559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16559
auccaggagu uuugccaugu                                                   20


<210>  16560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16560
ucacaagccu uauuauucag                                                   20


<210>  16561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16561
caaagaccuu ccuauccaca                                                   20


<210>  16562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16562
uugugacaua uggaagccag                                                   20


<210>  16563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16563
cguuggcugu ggauaggaag                                                   20


<210>  16564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16564
gcugaauacc ccuuucucca                                                   20


<210>  16565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16565
aaaaaaaucu ucauacuuua                                                   20


<210>  16566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16566
ccggccaacu gcaugcauaa                                                   20


<210>  16567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16567
gagagggcag aaucgcucga                                                   20


<210>  16568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16568
agcgauucug cccucuccga                                                   20


<210>  16569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16569
aucugugaga uccaggggcu                                                   20


<210>  16570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16570
cgguagggca gugcuagguc                                                   20


<210>  16571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16571
cucggagguu aaaauuauag                                                   20


<210>  16572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16572
cccucaaggu acacgagugc                                                   20


<210>  16573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16573
ccaggcuccc ugggcuccca                                                   20


<210>  16574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16574
uccccucauc accaaaguau                                                   20


<210>  16575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16575
gccaaaccca ggcccaaguc                                                   20


<210>  16576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16576
uuuaggugcc agccaucuau                                                   20


<210>  16577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16577
uaauacacua uaauagccaa                                                   20


<210>  16578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16578
ucuccccaaa ugagaacgau                                                   20


<210>  16579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16579
aaccuugagu aauuacauau                                                   20


<210>  16580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16580
ucauguaaau uaaauauguc                                                   20


<210>  16581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16581
aaucucuugg ugaacuuuua                                                   20


<210>  16582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16582
gccugcugaa ggagaaaaaa                                                   20


<210>  16583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16583
uuccaguaau ugcgaauugu                                                   20


<210>  16584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16584
uuagaauuua caacuaggua                                                   20


<210>  16585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16585
gcccacacca ugcauauuca                                                   20


<210>  16586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16586
ggaagauauu acaauuuugc                                                   20


<210>  16587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16587
agccaaaggg gcuaagauac                                                   20


<210>  16588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16588
cggacuuugu ucauaaaacu                                                   20


<210>  16589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16589
gugacgaugu uugcagccuc                                                   20


<210>  16590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16590
cucauaggca auacugcaua                                                   20


<210>  16591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16591
uccaacagaa cagauuaaca                                                   20


<210>  16592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16592
cuccacccuu ccaaaaagcc                                                   20


<210>  16593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16593
cuccugugua aacauccacu                                                   20


<210>  16594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16594
gguuuacuuc ugaggagugc                                                   20


<210>  16595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16595
ugcagacauc agcugacauu                                                   20


<210>  16596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16596
gcaugacccg uucaccaugg                                                   20


<210>  16597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16597
gcugaugucu gcaugacccg                                                   20


<210>  16598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16598
acccaccacc accaucccac                                                   20


<210>  16599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16599
ggagaagaau ccuuugcuug                                                   20


<210>  16600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16600
ggagguuagc aaggugugag                                                   20


<210>  16601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16601
cuagaauuuu uuaaauguca                                                   20


<210>  16602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16602
uaucucagcu ggugugcaag                                                   20


<210>  16603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16603
gacugagaau aacagcuucg                                                   20


<210>  16604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16604
gacuugcaca ccagcugaga                                                   20


<210>  16605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16605
cagcuuaccg cuccacugcu                                                   20


<210>  16606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16606
agcaguggag cgguaagcug                                                   20


<210>  16607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16607
gaggcugggg gagagagggg                                                   20


<210>  16608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16608
acaguccuga ccaauuccgu                                                   20


<210>  16609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16609
ugaccaauuc cguuugacac                                                   20


<210>  16610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16610
ggacugugga ccuguggcuc                                                   20


<210>  16611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16611
aacggaauug gucaggacug                                                   20


<210>  16612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16612
caucccauau caacccucau                                                   20


<210>  16613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16613
cauuugcucu guaguguagc                                                   20


<210>  16614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16614
gcagugugca ggcagcaggc                                                   20


<210>  16615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16615
cccuccccuc cuaucugcuu                                                   20


<210>  16616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16616
cagcucuggg ucccccuccc                                                   20


<210>  16617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16617
uuugugcuug ucccagcucu                                                   20


<210>  16618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16618
aacaacaaug ccugcuguca                                                   20


<210>  16619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16619
gcagcugaau uauuuuuaua                                                   20


<210>  16620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16620
gugcugacuu guuaagcaau                                                   20


<210>  16621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16621
gcacagacac guacuuguuu                                                   20


<210>  16622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16622
cacagcucca agaucagaag                                                   20


<210>  16623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16623
uugaagcugc ucaaauguuu                                                   20


<210>  16624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16624
uuuuaacuaa aacauuugag                                                   20


<210>  16625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16625
guuccuguac auuuuaaaua                                                   20


<210>  16626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16626
cucacaauga guuuuuguuu                                                   20


<210>  16627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16627
ccagguaucc ccuucaucaa                                                   20


<210>  16628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16628
cugccagaga auucccagug                                                   20


<210>  16629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16629
aucgugcacu gcgcguugcc                                                   20


<210>  16630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16630
ccagggugaa ccaagagaug                                                   20


<210>  16631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16631
ucucuugguu cacccuggag                                                   20


<210>  16632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16632
gcaaacuucu aauucgccag                                                   20


<210>  16633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16633
gaagcaguug ugguagaucc                                                   20


<210>  16634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16634
acauugcuug agguuuuaaa                                                   20


<210>  16635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16635
uuuagaucag uacuagauuu                                                   20


<210>  16636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16636
cucucucucu cucucucugu                                                   20


<210>  16637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16637
ccccaacucu gccaccuccc                                                   20


<210>  16638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16638
uucacacugg gcuaucuaag                                                   20


<210>  16639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16639
ggggaauugu auaaacuuag                                                   20


<210>  16640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16640
gaugcggagc uggaauauua                                                   20


<210>  16641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16641
cuucugaucc cagcagggaa                                                   20


<210>  16642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16642
uucugcaaug gcauugaguu                                                   20


<210>  16643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16643
auuucugagc ucauucguca                                                   20


<210>  16644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16644
cccugcuuuu uacuggccag                                                   20


<210>  16645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16645
gauguuuacu ggcuucaaau                                                   20


<210>  16646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16646
cuaggagcac auguagagag                                                   20


<210>  16647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16647
gguuacauuu ccuggaaauu                                                   20


<210>  16648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16648
caaacuuaau uuccaggaaa                                                   20


<210>  16649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16649
uuuucuguca caaacuuaau                                                   20


<210>  16650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16650
uguuguaaaa acuacguggc                                                   20


<210>  16651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16651
uaaaggggag aagcuguuua                                                   20


<210>  16652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16652
cccucccucc uugguucuuu                                                   20


<210>  16653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16653
auuuccuauu uguauuacaa                                                   20


<210>  16654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16654
uuauccauua aauuauauag                                                   20


<210>  16655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16655
gaacauauuu uaugaacuuc                                                   20


<210>  16656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16656
uccaaauuga uacauaacau                                                   20


<210>  16657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16657
gcaguguugu uauuucaagg                                                   20


<210>  16658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16658
uggcuauguc agcaguguug                                                   20


<210>  16659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16659
agcuugaugc uaagugcuuu                                                   20


<210>  16660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16660
guuuuuacau acaguaguac                                                   20


<210>  16661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16661
aaugacuucu uugugcaaua                                                   20


<210>  16662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16662
uuugacaaaa uuuaccccaa                                                   20


<210>  16663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16663
guucacaccc uuuauugcac                                                   20


<210>  16664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16664
cuggauguua auuuaaucua                                                   20


<210>  16665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16665
guaagaaagg aaacaaauuu                                                   20


<210>  16666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16666
uggaaaauca uuaauuucac                                                   20


<210>  16667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16667
ugacccugcc ugcacguuuc                                                   20


<210>  16668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16668
ggacaggcaa ccuucagcuc                                                   20


<210>  16669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16669
cccucugcuc cuguucuuga                                                   20


<210>  16670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16670
guaacagcag gagacagaaa                                                   20


<210>  16671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16671
ccugcuguua cagacaguua                                                   20


<210>  16672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16672
acgugauaug aagaucaucc                                                   20


<210>  16673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16673
ucuuuuauaa auaauguuuu                                                   20


<210>  16674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16674
ccacaagggu aaugucugaa                                                   20


<210>  16675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16675
gaagaaguuu gggaucuuua                                                   20


<210>  16676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16676
ugacaaugcc aacaauugua                                                   20


<210>  16677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16677
ggacuuuuga aagcuuaauu                                                   20


<210>  16678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16678
uacaauuguu ggcauuguca                                                   20


<210>  16679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16679
cagugauugc augauugagc                                                   20


<210>  16680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16680
uagaaagagu uucucugaca                                                   20


<210>  16681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16681
gagaaacucu uucuaagaca                                                   20


<210>  16682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16682
aaguacaaug ucagagaaac                                                   20


<210>  16683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16683
uauuuacaaa uacagcuugu                                                   20


<210>  16684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16684
uauauacaag cuguauuugu                                                   20


<210>  16685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16685
uuggauagug gccucacaaa                                                   20


<210>  16686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16686
gucguuuuua uucagaauca                                                   20


<210>  16687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16687
uuuuuauuca gaaucacaua                                                   20


<210>  16688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16688
uaauagcaua cuauaauuua                                                   20


<210>  16689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16689
cauuuacaau uacaccauaa                                                   20


<210>  16690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16690
gagcuaggag agaaucagaa                                                   20


<210>  16691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16691
gauauaucau uaucuaaaua                                                   20


<210>  16692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16692
aggcaaauaa uuuuaaauac                                                   20


<210>  16693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16693
auguucauga uuuuaaagag                                                   20


<210>  16694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16694
gcuccuguug auauauaaca                                                   20


<210>  16695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16695
uauaaaaugu aguaaagucu                                                   20


<210>  16696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16696
uauuuuuucu cuagucucuc                                                   20


<210>  16697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16697
cucaaaaagc uaacuuuaug                                                   20


<210>  16698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16698
uaaaguuagc uuuuugagag                                                   20


<210>  16699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16699
gauuugaggu uuuggcuuau                                                   20


<210>  16700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16700
uuucuauaag ggaacagcag                                                   20


<210>  16701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16701
cauauuuuau gaugggggga                                                   20


<210>  16702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16702
gagcuuucaa uagggguuuu                                                   20


<210>  16703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16703
aaggcugcug auaucugagg                                                   20


<210>  16704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16704
aauauccacc cucagauauc                                                   20


<210>  16705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16705
cucaagccug uaaucccagc                                                   20


<210>  16706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16706
ggaguucaag accagccugg                                                   20


<210>  16707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16707
ugaacuccug accucaggug                                                   20


<210>  16708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16708
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  16709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16709
cgaauucuaa gcuuuauuua                                                   20


<210>  16710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16710
cuguuuuauu cuugcuuccu                                                   20


<210>  16711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16711
uuuaagcgug cuggguagga                                                   20


<210>  16712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16712
caaaaagaaa ggagaagcaa                                                   20


<210>  16713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16713
gcuuuucuuu uuaugaugag                                                   20


<210>  16714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16714
gcacaauucc aagucugcuu                                                   20


<210>  16715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16715
uccagaacuu cgcuucaggg                                                   20


<210>  16716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16716
gaauuuaugu gcaaugguag                                                   20


<210>  16717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16717
ugauucuagu uacugacauc                                                   20


<210>  16718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16718
guaacuagaa ucacgacuuc                                                   20


<210>  16719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16719
caucucaaag ugagauguca                                                   20


<210>  16720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16720
ugauuucuuu cauuguguuu                                                   20


<210>  16721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16721
cagcacuugu ugugcgccca                                                   20


<210>  16722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16722
aagauauuca augggcgcac                                                   20


<210>  16723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16723
caguuaaaug auugauuauu                                                   20


<210>  16724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16724
aaagguucug uuauuauuuu                                                   20


<210>  16725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16725
uaacuauaug uaaggccuuc                                                   20


<210>  16726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16726
uagauuaacc agcucaaaaa                                                   20


<210>  16727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16727
caaauagguu auucagucuu                                                   20


<210>  16728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16728
agcaagaauu aaaaccacac                                                   20


<210>  16729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16729
gucaagcaag aauuaaaacc                                                   20


<210>  16730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16730
uuuaaacgag cagcucgaua                                                   20


<210>  16731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16731
ucggagaucc aaagccuugc                                                   20


<210>  16732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16732
ucuucggaga uccaaagccu                                                   20


<210>  16733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16733
caagacaaca cauggaaaug                                                   20


<210>  16734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16734
ugugacugga aggaaaauga                                                   20


<210>  16735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16735
uucccacauc cugcuggggg                                                   20


<210>  16736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16736
cauaagguaa auguggugga                                                   20


<210>  16737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16737
uauuauuucu ccucuccccc                                                   20


<210>  16738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16738
agaggggauu aaaugucaua                                                   20


<210>  16739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16739
guggucuaga ggggauuaaa                                                   20


<210>  16740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16740
aacuaggucg gagagacaag                                                   20


<210>  16741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16741
gagagacaag uuccagugaa                                                   20


<210>  16742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16742
cuccgaccua guuugaccac                                                   20


<210>  16743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16743
gucaucacag aaucugcauu                                                   20


<210>  16744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16744
ucacagaauc ugcauugacu                                                   20


<210>  16745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16745
augcagauuc ugugaugaca                                                   20


<210>  16746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16746
aacaugcuca agcaaaaaau                                                   20


<210>  16747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16747
cuauauagug uuacuguuua                                                   20


<210>  16748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16748
cacugcuagc cuuuaauucc                                                   20


<210>  16749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16749
ggacuggaca uuuguaaggg                                                   20


<210>  16750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16750
agacuccacu guuucugcua                                                   20


<210>  16751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16751
aguccagacu ccacuguuuc                                                   20


<210>  16752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16752
cccuuacaaa uguccagucc                                                   20


<210>  16753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16753
aaaccacauc agagacaaga                                                   20


<210>  16754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16754
cugauguggu uuugacagau                                                   20


<210>  16755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16755
aaccaaccuu uugaaauuuc                                                   20


<210>  16756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16756
gugcgcuuca gcaacugccc                                                   20


<210>  16757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16757
aaaauggcau cuuaaaguca                                                   20


<210>  16758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16758
aggucauggu gucaucccac                                                   20


<210>  16759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16759
uggugucauc ccaccacggg                                                   20


<210>  16760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16760
ucccaccacg gggcuguguu                                                   20


<210>  16761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16761
gcccggaugg ggcuguaauu                                                   20


<210>  16762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16762
aacaagucau uggcugaacu                                                   20


<210>  16763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16763
uuggcugaac ugcaaaugcc                                                   20


<210>  16764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16764
gaggcaaagu ggccauauag                                                   20


<210>  16765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16765
ccaaggcugg aaauggacaa                                                   20


<210>  16766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16766
auuuccagcc uuggugacgu                                                   20


<210>  16767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16767
agcuuccauu guccauuucc                                                   20


<210>  16768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16768
auuuuggauu ucuuuucuuc                                                   20


<210>  16769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16769
gaugugugua ccuauccugc                                                   20


<210>  16770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16770
agaacacaga aaaauaaaua                                                   20


<210>  16771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16771
uggacaguca cauagaguaa                                                   20


<210>  16772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16772
augacagccc uguaauguua                                                   20


<210>  16773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16773
cauagaguaa uagagaaagc                                                   20


<210>  16774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16774
ucuagaggaa uuugccccaa                                                   20


<210>  16775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16775
uccucuggcg ugaccuggau                                                   20


<210>  16776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16776
cgccagagga ugacgauugu                                                   20


<210>  16777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16777
cccaauggga aguucaucug                                                   20


<210>  16778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16778
ugauccccuu cuggagcucc                                                   20


<210>  16779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16779
gguucaucau cuguaagaau                                                   20


<210>  16780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16780
ucucuggcac ucuaauaauu                                                   20


<210>  16781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16781
augaggcaaa ucaucacaua                                                   20


<210>  16782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16782
uccuugcaua acuccagaga                                                   20


<210>  16783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16783
gguuuguaag uuuagaaaga                                                   20


<210>  16784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16784
auugugccaa agaaugaaag                                                   20


<210>  16785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16785
guuuacuuag gaguauauac                                                   20


<210>  16786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16786
caugaaaaau gugccacauu                                                   20


<210>  16787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16787
uuuucuuauu acagcagugu                                                   20


<210>  16788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16788
cagcauaauu cacacugcca                                                   20


<210>  16789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16789
gagaaauacu gcccgugcau                                                   20


<210>  16790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16790
uuuuuuuuuu auucugagaa                                                   20


<210>  16791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16791
agcaaacacc acauuucaga                                                   20


<210>  16792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16792
uuucuuuaga cuugaaauac                                                   20


<210>  16793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16793
aaagaaagga cuucucagcc                                                   20


<210>  16794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16794
aaguggacua auuuucugaa                                                   20


<210>  16795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16795
acuuugacaa cauuaggcga                                                   20


<210>  16796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16796
cauaaugaag cauuuuggag                                                   20


<210>  16797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16797
accuuguuau accauccgcu                                                   20


<210>  16798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16798
uucuuuccug uuugcuuuuu                                                   20


<210>  16799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16799
cugcuuguga aaucuuaugc                                                   20


<210>  16800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16800
uaaacaguua aucagucuga                                                   20


<210>  16801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16801
gaccuucuuu agcaagcugc                                                   20


<210>  16802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16802
gacugauuaa cuguuuaaga                                                   20


<210>  16803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16803
uacuugagca caggugcagc                                                   20


<210>  16804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16804
ccacaggaau augaagguua                                                   20


<210>  16805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16805
uuauuaguag gaauauaacc                                                   20


<210>  16806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16806
ucuuuuauuu gaaaaguaug                                                   20


<210>  16807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16807
uucuucucuu acauuugcuu                                                   20


<210>  16808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16808
aaauggaagc aaauguaaga                                                   20


<210>  16809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16809
gaauuaagga uuuuaaguac                                                   20


<210>  16810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16810
guaaaccuca gaacuuguag                                                   20


<210>  16811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16811
uccuucaguc uguaaaccuc                                                   20


<210>  16812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16812
gacacauuuc uaaaaguggg                                                   20


<210>  16813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16813
gaccuuggga acaaaaaaaa                                                   20


<210>  16814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16814
guuuugaacc acauuaccuu                                                   20


<210>  16815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16815
ucuaaaugua gugacugaac                                                   20


<210>  16816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16816
cuacauuuag aagacuuuaa                                                   20


<210>  16817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16817
ccuugcaaaa cauuuggcua                                                   20


<210>  16818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16818
gauuuuuaau aauauaccag                                                   20


<210>  16819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16819
cacuuugucu gauuuuuaau                                                   20


<210>  16820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16820
acugauuugc auugacaucu                                                   20


<210>  16821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16821
augcaaauca guagacuaca                                                   20


<210>  16822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16822
ucgauugaag uggaagggag                                                   20


<210>  16823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16823
ugcuguuuga acguagaagc                                                   20


<210>  16824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16824
caaugucuca gugacagacu                                                   20


<210>  16825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16825
cagugacaga cugagaucuc                                                   20


<210>  16826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16826
cugagacauu gagacguucc                                                   20


<210>  16827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16827
gucacugaga cauugagacg                                                   20


<210>  16828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16828
ucaaguuugc uuuccaaguc                                                   20


<210>  16829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16829
uucuccuuga uugucuuaac                                                   20


<210>  16830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16830
uaacagggua aagaagcaaa                                                   20


<210>  16831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16831
acccuugccg gggccccugc                                                   20


<210>  16832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16832
ccgcgcccaa cuucacuuuc                                                   20


<210>  16833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16833
ccgggccccc gggccccaag                                                   20


<210>  16834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16834
gggccccugg cugcccuccg                                                   20


<210>  16835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16835
agcucggcca gcucggccgc                                                   20


<210>  16836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16836
ccccgcggcc gagcuggccg                                                   20


<210>  16837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16837
caguaucucc gcacacaccu                                                   20


<210>  16838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16838
ugagauucau ucugugucca                                                   20


<210>  16839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16839
acaagcuuac acuuuuuacu                                                   20


<210>  16840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16840
uuaauaauga auaaccgcag                                                   20


<210>  16841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16841
ggcugcagag ccgcccagca                                                   20


<210>  16842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16842
gugcuuugca ugggggugag                                                   20


<210>  16843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16843
ccagccucac uucuuccacc                                                   20


<210>  16844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16844
cagcucgcgc acgggggugu                                                   20


<210>  16845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16845
gccgcgcgcc cggucgcuuc                                                   20


<210>  16846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16846
cuucuccgcg gccccggcca                                                   20


<210>  16847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16847
aaaugaagaa caaagacaua                                                   20


<210>  16848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16848
uuguucuuca uuuugacuuu                                                   20


<210>  16849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16849
ggggaggaac gagcuuugcg                                                   20


<210>  16850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16850
cuaggaggca gaacaagauc                                                   20


<210>  16851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16851
ucaguaccac ccccccgccc                                                   20


<210>  16852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16852
ucauuuucug ggugcucaga                                                   20


<210>  16853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16853
cgggguuaaa gggccaguuu                                                   20


<210>  16854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16854
caagauggac ccaggaggga                                                   20


<210>  16855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16855
aucuugggac acucuaggcu                                                   20


<210>  16856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16856
aggcugcucc cucguacccc                                                   20


<210>  16857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16857
guccuuugag cccccacugc                                                   20


<210>  16858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16858
uuugagcccc cacugcaucc                                                   20


<210>  16859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16859
ggcccuucuu cggaaggaug                                                   20


<210>  16860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16860
ugcgaacacu gcccuuccuu                                                   20


<210>  16861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16861
gauccgcauc cggcgcggcc                                                   20


<210>  16862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16862
cacacuucgg aagcuccccc                                                   20


<210>  16863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16863
uuuaaaacug caucaaaaau                                                   20


<210>  16864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16864
gcgggagaca gccaccacca                                                   20


<210>  16865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16865
cccgcugacu gcgccuggaa                                                   20


<210>  16866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16866
guauaagagc uggugguggu                                                   20


<210>  16867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16867
gagguucuug ugagucugua                                                   20


<210>  16868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16868
ugcccucuuc cccaggccug                                                   20


<210>  16869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16869
caggauccag cgcccuuaaa                                                   20


<210>  16870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16870
ugcucggggc gcagggggac                                                   20


<210>  16871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16871
cccugcgccc cgagcacgac                                                   20


<210>  16872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16872
ccaguccccc ugcgccccga                                                   20


<210>  16873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16873
ggucaccagu cccccugcgc                                                   20


<210>  16874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16874
ccacgugcuu ucccugccca                                                   20


<210>  16875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16875
cgagcugugg acaagagacg                                                   20


<210>  16876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16876
acagcucggg accgcgagga                                                   20


<210>  16877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16877
cuuguccaca gcucgggacc                                                   20


<210>  16878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16878
gagaaaguac ccagggcgga                                                   20


<210>  16879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16879
gggaggucga gaagaggucu                                                   20


<210>  16880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16880
agaagagguc ucggcauugu                                                   20


<210>  16881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16881
cggcauugug cugggggcgg                                                   20


<210>  16882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16882
gcccccagca caaugccgag                                                   20


<210>  16883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16883
ugguccgccc ccagcacaau                                                   20


<210>  16884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16884
ccgcgccagc cuggcccgug                                                   20


<210>  16885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16885
ggcaaggccc gggcgaggcc                                                   20


<210>  16886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16886
ucugucuguu uguuggcagg                                                   20


<210>  16887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16887
guuuguuggc aggaggcucc                                                   20


<210>  16888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16888
gaauguuuac aagcaccgcg                                                   20


<210>  16889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16889
gcgcccuaag uuugcaacug                                                   20


<210>  16890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16890
aagagaaggc cgucacagaa                                                   20


<210>  16891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16891
cagaaaaggg uuggcagagc                                                   20


<210>  16892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16892
ucuccuugcu gccucugagg                                                   20


<210>  16893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16893
ggaggggagg gcagcggcaa                                                   20


<210>  16894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16894
gggcucccuc ccucccucuc                                                   20


<210>  16895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16895
cgcugccuuu ugugccggcu                                                   20


<210>  16896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16896
cccguccuuc ccggucccac                                                   20


<210>  16897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16897
uucccggucc cacggcucuc                                                   20


<210>  16898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16898
cacggcucuc cccgucgccg                                                   20


<210>  16899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16899
ccgcggcccc ucucccgacu                                                   20


<210>  16900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16900
ggagaggggc cgcggcgacg                                                   20


<210>  16901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16901
gcggagucgg gagaggggcc                                                   20


<210>  16902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16902
uccccacaau agugagaaag                                                   20


<210>  16903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16903
agugugcagc gggaggaaag                                                   20


<210>  16904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16904
aaaagccagu cucaccucuu                                                   20


<210>  16905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16905
caccucuuuu cuccccggga                                                   20


<210>  16906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16906
aaaaaacgau ucccggggag                                                   20


<210>  16907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16907
aauuuuugua aaauuaaaua                                                   20


<210>  16908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16908
caaaagugca uacacggcaa                                                   20


<210>  16909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16909
agguaaaaga gauaaagggg                                                   20


<210>  16910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16910
ugcgcgcucu cgugauuauu                                                   20


<210>  16911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16911
cgccgcaagc aaggcaaacc                                                   20


<210>  16912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16912
gcccgccgcc gccgccgccg                                                   20


<210>  16913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16913
uccgcccgcc gccgccgccg                                                   20


<210>  16914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16914
ccuucuuucu aacccggcuc                                                   20


<210>  16915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16915
aaaggcacug augaagauau                                                   20


<210>  16916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16916
uggcuuuuuu uuaagcaaaa                                                   20


<210>  16917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16917
gcacuugaac uugcagcuca                                                   20


<210>  16918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16918
cguccgcacu ugaacuugca                                                   20


<210>  16919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16919
cugcgaacuu gaacgucagg                                                   20


<210>  16920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16920
ggagucugga uggacagaga                                                   20


<210>  16921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16921
ggauggacag agacacacaa                                                   20


<210>  16922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16922
auccagacuc cugacguuca                                                   20


<210>  16923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16923
cuguccaucc agacuccuga                                                   20


<210>  16924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16924
auugguguga gcuuccccuu                                                   20


<210>  16925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16925
agccccugau guguguccau                                                   20


<210>  16926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16926
cuuuuucaug uccagccccu                                                   20


<210>  16927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16927
uggucucuuu uucaugucca                                                   20


<210>  16928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16928
gcggagcccc ccgccccgca                                                   20


<210>  16929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16929
ggcguccgcg gagccccccg                                                   20


<210>  16930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16930
ugcucccccc cacccuuucc                                                   20


<210>  16931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16931
gcgugugugg gggggagcag                                                   20


<210>  16932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16932
gggagcaacu cuaccuggcu                                                   20


<210>  16933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16933
acacgcgggg agcgagcgcg                                                   20


<210>  16934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16934
ucuccucggg caaaguuucc                                                   20


<210>  16935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16935
ggaagggcag cgcccaaguc                                                   20


<210>  16936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16936
ccaggagccc gcgcggccug                                                   20


<210>  16937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16937
ccucuuucca ggccgcgcgg                                                   20


<210>  16938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16938
cuggcucggc cuugggggcg                                                   20


<210>  16939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16939
cuuggcgggg cgcucagauu                                                   20


<210>  16940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16940
gaaugcaacu gaaagcgccg                                                   20


<210>  16941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16941
ccggcuccua agggucgcag                                                   20


<210>  16942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16942
cagaaagaga gcccgaggaa                                                   20


<210>  16943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16943
ggcccccgga ggggagcgcc                                                   20


<210>  16944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16944
accucucuga gaggccgagg                                                   20


<210>  16945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16945
ucggccucuc agagaggugg                                                   20


<210>  16946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16946
cgggaguccc agucccuggg                                                   20


<210>  16947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16947
cagucccugg gaaugugcuc                                                   20


<210>  16948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16948
cugggaaugu gcucacggcg                                                   20


<210>  16949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16949
ccgagccggg ucccugggag                                                   20


<210>  16950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16950
cugggaggga cacacccccu                                                   20


<210>  16951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16951
cucccaggga cccggcucgg                                                   20


<210>  16952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16952
cucucucucc auucccauuu                                                   20


<210>  16953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16953
ccccgcugcu ccugcgagcc                                                   20


<210>  16954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16954
ucucaccacc guggucuccc                                                   20


<210>  16955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16955
ccgccgcgcu ccccaggcgc                                                   20


<210>  16956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16956
gcagaaaggc gagagggggc                                                   20


<210>  16957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16957
ucccuaauuu ccagggaacg                                                   20


<210>  16958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16958
cuuuaaugca cacacgcaca                                                   20


<210>  16959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16959
aaaagcgggc uucacucugg                                                   20


<210>  16960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16960
ccuggcgccu cccgccuccc                                                   20


<210>  16961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16961
gauuccaaau cuggaaggag                                                   20


<210>  16962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16962
auucuccucu ccccccaacu                                                   20


<210>  16963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16963
aagggaggug cggagggugc                                                   20


<210>  16964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16964
ccacccugca cccuccgcac                                                   20


<210>  16965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16965
ccauggcccg cgagacccug                                                   20


<210>  16966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16966
cgcgggccau ggcgacccgu                                                   20


<210>  16967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16967
gcagagcgag gagcccuccu                                                   20


<210>  16968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16968
ucucaucccc cucuucaguc                                                   20


<210>  16969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16969
aaaggguguc gcuuccguaa                                                   20


<210>  16970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16970
cuuccguaaa cucacccacc                                                   20


<210>  16971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16971
uaguaaaguu ucaagucuac                                                   20


<210>  16972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16972
acuguguuag aaaaugacug                                                   20


<210>  16973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16973
uuuucuaaca caguagacuu                                                   20


<210>  16974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16974
gaagcuccgc cgagcuaggc                                                   20


<210>  16975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16975
augugguuug uuguuuguug                                                   20


<210>  16976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16976
cccucccaca aacuggaggg                                                   20


<210>  16977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16977
cacacaagcu acagagcuua                                                   20


<210>  16978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16978
gcaucucuau uccaccacag                                                   20


<210>  16979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16979
gcuuuuuguc uuguuaaacc                                                   20


<210>  16980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16980
uguuaaacca gccuuggagu                                                   20


<210>  16981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16981
ccaaaagaau gucuucuugg                                                   20


<210>  16982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16982
ucuugggggg uggcggggga                                                   20


<210>  16983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16983
ucccccgcca ccccccaaga                                                   20


<210>  16984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16984
uccucccccg ccacccccca                                                   20


<210>  16985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16985
cccacgucgu ccucccccgc                                                   20


<210>  16986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16986
auaaaagucc aucuauagag                                                   20


<210>  16987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16987
aucuauagag aagauauaua                                                   20


<210>  16988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16988
uuacuuuuua cacuacagcc                                                   20


<210>  16989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16989
ucugaauuac aauucauuac                                                   20


<210>  16990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16990
gagcgcacac aauuguguaa                                                   20


<210>  16991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16991
gcuauguuau ugcacuuguu                                                   20


<210>  16992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16992
cugcuuaccu cuccuuuggc                                                   20


<210>  16993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16993
gggaaucguc gcugcuuacc                                                   20


<210>  16994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16994
agaaaaccac ggcugugugu                                                   20


<210>  16995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16995
gcauuugauc ccuccugguc                                                   20


<210>  16996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16996
ucgacccccc uccccggccc                                                   20


<210>  16997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16997
accccccucc ccggccccug                                                   20


<210>  16998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16998
acgaccagga gggaucaaau                                                   20


<210>  16999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  16999
cccuagggga gggcaccagg                                                   20


<210>  17000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17000
uuuuaagaga uuuuaaaaua                                                   20


<210>  17001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17001
cuuuaaaugc gcacacuugg                                                   20


<210>  17002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17002
uaauuuauua cuuucuaaaa                                                   20


<210>  17003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17003
ccaaagguuu gggaaagagc                                                   20


<210>  17004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17004
ucaccaaagg uuugggaaag                                                   20


<210>  17005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17005
gcuggccugg aguuuacacg                                                   20


<210>  17006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17006
ucugcuggcc uggaguuuac                                                   20


<210>  17007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17007
ccuccgcggg caagauaaaa                                                   20


<210>  17008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17008
uggggcgucu ccuccgcggg                                                   20


<210>  17009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17009
uaguuuaugc uuuauaaugu                                                   20


<210>  17010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17010
acacauuaua aagcauaaac                                                   20


<210>  17011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17011
guuagaaaac uugucaacac                                                   20


<210>  17012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17012
guuagaaacc caccguauuu                                                   20


<210>  17013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17013
uuucaguagu uuucgguaug                                                   20


<210>  17014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17014
ggaggccacg cggcucauac                                                   20


<210>  17015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17015
uuuuuuuuuu cuaaaagguu                                                   20


<210>  17016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17016
acaaacagcu cgaagaggga                                                   20


<210>  17017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17017
cccucuucga gcuguuuguu                                                   20


<210>  17018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17018
cagcccucgg accgaggauc                                                   20


<210>  17019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17019
gagggcuggg acuguauuaa                                                   20


<210>  17020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17020
gucaggaugg aaacuacaag                                                   20


<210>  17021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17021
ggauggaaac uacaagauua                                                   20


<210>  17022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17022
gccuuuaggg ggaaacaccu                                                   20


<210>  17023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17023
augaaggugu uucccccuaa                                                   20


<210>  17024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17024
uucacuuauu uaucuuugag                                                   20


<210>  17025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17025
caaaauagag aacaggcagu                                                   20


<210>  17026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17026
ucuucauaaa aauaaaacuu                                                   20


<210>  17027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17027
caaugaugga agugcuaggc                                                   20


<210>  17028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17028
uaacaacagc cuagcacuuc                                                   20


<210>  17029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17029
ggaguucaag accagccugg                                                   20


<210>  17030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17030
ugaacuccug accucaagug                                                   20


<210>  17031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17031
caccuacuug ggaggcugag                                                   20


<210>  17032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17032
cccagguuca agcgauucuu                                                   20


<210>  17033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17033
caaaaaaaua auaauaaaaa                                                   20


<210>  17034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17034
cacugggagu agaggaggaa                                                   20


<210>  17035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17035
cuggaggaca guaucuauac                                                   20


<210>  17036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17036
uccagggacc ucccaaccug                                                   20


<210>  17037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17037
gugccuuugu agaagguaua                                                   20


<210>  17038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17038
ggcaucuuuc ucuccaggcu                                                   20


<210>  17039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17039
gcgcuucaaa caccugaaug                                                   20


<210>  17040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17040
auacuuuccu cuagaugagg                                                   20


<210>  17041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17041
auaauguaug gggaagaggg                                                   20


<210>  17042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17042
uaccacauaa guaaggggcc                                                   20


<210>  17043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17043
cuuccaaggg gccccuuacu                                                   20


<210>  17044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17044
auauuaggaa gcuaaacuga                                                   20


<210>  17045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17045
uugaugucaa uauuaggaag                                                   20


<210>  17046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17046
aaugaaugua cugcacuaga                                                   20


<210>  17047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17047
aauaaauggu cuuugauaaa                                                   20


<210>  17048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17048
uugauaaaua auaaauuaau                                                   20


<210>  17049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17049
ccagcagcau acauuaucaa                                                   20


<210>  17050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17050
cauuugagaa agcaguuuug                                                   20


<210>  17051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17051
gacauuuugu acagccagcu                                                   20


<210>  17052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17052
gaccagaugu gugugugugu                                                   20


<210>  17053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17053
gcguuuccau uauaaaccca                                                   20


<210>  17054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17054
gucagcguuu ccauuauaaa                                                   20


<210>  17055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17055
ggcagggcug cuauaauuaa                                                   20


<210>  17056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17056
gucaguguuu cuauuauaaa                                                   20


<210>  17057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17057
guguuucuau uauaaacccc                                                   20


<210>  17058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17058
agaugugaac uuguuuuaua                                                   20


<210>  17059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17059
uauugccaac uuccagcuau                                                   20


<210>  17060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17060
uagcuggaag uuggcaauaa                                                   20


<210>  17061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17061
uuuauuugga caaguacucu                                                   20


<210>  17062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17062
aaauaaagga cuaacugccu                                                   20


<210>  17063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17063
ugauuuuuaa guuguuucuu                                                   20


<210>  17064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17064
caacauuccu uggcauauag                                                   20


<210>  17065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17065
accaacugug ugguaaaaau                                                   20


<210>  17066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17066
uccugaguua cccaaggacu                                                   20


<210>  17067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17067
uuggguaacu caggaugacu                                                   20


<210>  17068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17068
agcagagaaa uacauggugu                                                   20


<210>  17069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17069
aagucaagca gagaaauaca                                                   20


<210>  17070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17070
acagucaaag ucaagcagag                                                   20


<210>  17071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17071
accggauuau acaaaguaaa                                                   20


<210>  17072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17072
accagagggc aguagaaaua                                                   20


<210>  17073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17073
gccaccugau guuuauggag                                                   20


<210>  17074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17074
cauuuuggug gaggugccau                                                   20


<210>  17075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17075
gccaacaaca uccagccaag                                                   20


<210>  17076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17076
cugacuucac acagaaaggc                                                   20


<210>  17077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17077
gugaccuuag ggucugccaa                                                   20


<210>  17078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17078
gagggaauag aggaaaggaa                                                   20


<210>  17079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17079
gaucccaguc agagggaaua                                                   20


<210>  17080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17080
ucaguggccu aauuuggugg                                                   20


<210>  17081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17081
ccucuggaau ucaaugagug                                                   20


<210>  17082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17082
cucauugaau uccagaggag                                                   20


<210>  17083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17083
ucaaaacaug ucaccaggcu                                                   20


<210>  17084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17084
ccaggcucaa guuccuucuc                                                   20


<210>  17085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17085
cauaaacccc auaauugccu                                                   20


<210>  17086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17086
uucccagaga gcacugcaca                                                   20


<210>  17087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17087
gggcugugca gugcucucug                                                   20


<210>  17088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17088
cuucucuaga aauuaagacu                                                   20


<210>  17089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17089
uaauuucuag agaagggacc                                                   20


<210>  17090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17090
auagucuuuu uugguuuuuu                                                   20


<210>  17091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17091
uuuuugguuu uuucuuguca                                                   20


<210>  17092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17092
aauucagcaa agggaacuuu                                                   20


<210>  17093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17093
ucuuucuuug gcagcuuagu                                                   20


<210>  17094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17094
uaagaauugu uauucuuucc                                                   20


<210>  17095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17095
cugcuuuugg augauugguu                                                   20


<210>  17096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17096
uaccgccuua aaaaacaaaa                                                   20


<210>  17097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17097
cauaaaguuc accagucaca                                                   20


<210>  17098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17098
cacaugccaa agccauacaa                                                   20


<210>  17099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17099
cucugacacc agauuuguac                                                   20


<210>  17100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17100
gagugaccag agcuguguug                                                   20


<210>  17101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17101
ggucauagau aucugugauc                                                   20


<210>  17102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17102
uagauaucug ugaucaucua                                                   20


<210>  17103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17103
auaauauugc cuacaaaaca                                                   20


<210>  17104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17104
gagucucgcu cuuucaccuc                                                   20


<210>  17105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17105
cgcucuuuca ccucuggaau                                                   20


<210>  17106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17106
ggaguucgag gccagccugg                                                   20


<210>  17107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17107
cccaaagugc ugggauuaua                                                   20


<210>  17108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17108
agccaauuuu uuguuuuggu                                                   20


<210>  17109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17109
uuuucacugg cagcagcaac                                                   20


<210>  17110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17110
cucuguguau auuccauaua                                                   20


<210>  17111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17111
uaaaagccac cacaucaccc                                                   20


<210>  17112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17112
uaaguuguua gagcuuauag                                                   20


<210>  17113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17113
cugucauuuu caucuuucuc                                                   20


<210>  17114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17114
uuuucaucuu ucucucccuc                                                   20


<210>  17115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17115
gguacaugaa caaagacuua                                                   20


<210>  17116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17116
uuguucaugu accagacauu                                                   20


<210>  17117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17117
augguagaua ggauuuugaa                                                   20


<210>  17118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17118
uuuuuauugu ucucaauucu                                                   20


<210>  17119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17119
cucagaguua cucuguuaug                                                   20


<210>  17120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17120
ggagaaucag ccuccagaau                                                   20


<210>  17121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17121
ugauauuuaa agaacguagu                                                   20


<210>  17122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17122
agcugguuuu cauuugcaac                                                   20


<210>  17123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17123
agagcauaua cugauauuuc                                                   20


<210>  17124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17124
uacuucuuua cucaucauau                                                   20


<210>  17125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17125
gaagcuuagu uuauuuuaaa                                                   20


<210>  17126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17126
ucagaauucc aagauggauc                                                   20


<210>  17127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17127
cauuaaguua aagagaucca                                                   20


<210>  17128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17128
auacuugugu uuucagcuau                                                   20


<210>  17129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17129
aucuuacuga ggguaaaaua                                                   20


<210>  17130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17130
uaaauguauu aauuuugguu                                                   20


<210>  17131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17131
cuauggaugc uaaaagggac                                                   20


<210>  17132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17132
cuuuuagcau ccauagugac                                                   20


<210>  17133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17133
ccacagcacu acgcguucuu                                                   20


<210>  17134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17134
ccaguauuau ugauagcaca                                                   20


<210>  17135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17135
uuauuaugua aaaccuaauu                                                   20


<210>  17136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17136
uguggaauuc cacuaucaug                                                   20


<210>  17137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17137
auuguacuua auuuccuuuu                                                   20


<210>  17138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17138
uccugcuucc ucccuguauc                                                   20


<210>  17139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17139
cauccucccu gaauguuccu                                                   20


<210>  17140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17140
aaguaucacc aacuaaagag                                                   20


<210>  17141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17141
ugagguggag auaagauuag                                                   20


<210>  17142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17142
gcaucauaau ugaaauuaca                                                   20


<210>  17143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17143
ggaccaugga cagcuuccac                                                   20


<210>  17144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17144
agacacucag gccuguuugg                                                   20


<210>  17145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17145
augguccaga cacucaggcc                                                   20


<210>  17146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17146
agaagggcug aaagaaaagg                                                   20


<210>  17147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17147
cagaagagaa uaguuucauu                                                   20


<210>  17148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17148
ggcaaugaau aaguaagucu                                                   20


<210>  17149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17149
augcugauuu uuuuuucuca                                                   20


<210>  17150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17150
cugauuccuu gaaaauagau                                                   20


<210>  17151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17151
uauaacuucc aaaauauucc                                                   20


<210>  17152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17152
ccuauuaguc acugcuccua                                                   20


<210>  17153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17153
cugcuccuau augauccuuu                                                   20


<210>  17154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17154
ggaaagguaa cagaaaaaua                                                   20


<210>  17155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17155
aagaaaggga gaauaaaauu                                                   20


<210>  17156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17156
gccacaguuc cacuuuaaac                                                   20


<210>  17157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17157
uaguaagugg caggaaauuc                                                   20


<210>  17158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17158
uuagcuuaua guguagacug                                                   20


<210>  17159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17159
acacuauaag cuaaugacuc                                                   20


<210>  17160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17160
agucuacacu auaagcuaau                                                   20


<210>  17161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17161
cucuauuaca gauuuucaua                                                   20


<210>  17162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17162
gcuacccccc gcccugccca                                                   20


<210>  17163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17163
gaauuauauc auauuauucu                                                   20


<210>  17164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17164
auugaauaca uaauaugcau                                                   20


<210>  17165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17165
ugugaauaua uauucaggca                                                   20


<210>  17166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17166
uugcucugau caaaucacaa                                                   20


<210>  17167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17167
aucacaucaa aucacauaca                                                   20


<210>  17168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17168
ucuuauuuaa auucuaaagu                                                   20


<210>  17169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17169
uucaucaagg cuugccuugg                                                   20


<210>  17170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17170
aacagaaaaa guugaguguc                                                   20


<210>  17171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17171
uccacuuugc uguagcugua                                                   20


<210>  17172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17172
gagcucaaca cacaggauac                                                   20


<210>  17173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17173
cucaccuucu agacacuccg                                                   20


<210>  17174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17174
agaaggugag cgacagagcg                                                   20


<210>  17175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17175
cuugauucaa uagauugaau                                                   20


<210>  17176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17176
gcucacagau gcagauaaga                                                   20


<210>  17177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17177
accugcuuag gcugcauauu                                                   20


<210>  17178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17178
ucauguuuaa ucuaguguag                                                   20


<210>  17179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17179
uguaaaauaa augcgggcua                                                   20


<210>  17180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17180
cucucccccc aauuaucaua                                                   20


<210>  17181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17181
gaaaaaugcu aguguggcua                                                   20


<210>  17182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17182
gaucccaggc acucuccuag                                                   20


<210>  17183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17183
cugaaaacaa ugcaaaagga                                                   20


<210>  17184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17184
ucuaacagau uuccaauggu                                                   20


<210>  17185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17185
aaagccagaa agacugauuu                                                   20


<210>  17186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17186
uucuggcuuu ggaccauugg                                                   20


<210>  17187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17187
accccuaaug uaaugccuaa                                                   20


<210>  17188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17188
aacuucugaa ucaauaagga                                                   20


<210>  17189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17189
ugcuaaaggg gaggggggga                                                   20


<210>  17190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17190
gucuucagau aaaaaaaaga                                                   20


<210>  17191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17191
ucagauaaaa aaaagauauc                                                   20


<210>  17192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17192
gaaagaaaag cuaugaauau                                                   20


<210>  17193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17193
cagaaugaaa ucgcuucauc                                                   20


<210>  17194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17194
guagcagccu cacagauaga                                                   20


<210>  17195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17195
agguuagccc aggcugcuau                                                   20


<210>  17196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17196
caggaaaggu caagguuagc                                                   20


<210>  17197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17197
acauugauca aggcagaacg                                                   20


<210>  17198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17198
ccuggaaggg cugggcagac                                                   20


<210>  17199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17199
gcccagcccu uccaggagac                                                   20


<210>  17200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17200
ugugauuuga uauuucauuc                                                   20


<210>  17201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17201
gggagcucuu acagagcuua                                                   20


<210>  17202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17202
gauuugauuu ugguaucuuu                                                   20


<210>  17203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17203
gaauucagag auggaaaaac                                                   20


<210>  17204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17204
gagaaaagag acacagagga                                                   20


<210>  17205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17205
cuuuucucug acucuccucu                                                   20


<210>  17206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17206
uugggaaagg aggaaugugg                                                   20


<210>  17207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17207
ccuucuccag aucacccacu                                                   20


<210>  17208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17208
gccucuuuac cacccagccc                                                   20


<210>  17209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17209
cgugggcagc ccgugggcag                                                   20


<210>  17210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17210
auuucuuuug agcugcugcc                                                   20


<210>  17211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17211
gucaauuucu uuugagcugc                                                   20


<210>  17212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17212
uuuccauaua uugaaaugcg                                                   20


<210>  17213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17213
uuuuucuagu ucugcuucau                                                   20


<210>  17214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17214
cuucccacuu ccaaccuaca                                                   20


<210>  17215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17215
gggguggggg cgcgcggugg                                                   20


<210>  17216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17216
acgacgauuu uuuccuuuuc                                                   20


<210>  17217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17217
uagaccggau guuuccaauu                                                   20


<210>  17218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17218
gaaaauuuuu ugaaagggaa                                                   20


<210>  17219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17219
cagauaaucc gaggcagggc                                                   20


<210>  17220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17220
uuuucuuuuu ucuuuaucau                                                   20


<210>  17221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17221
uuuaaguuug cuaagggaac                                                   20


<210>  17222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17222
uuuuugaacu aaugcugugc                                                   20


<210>  17223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17223
ccgcaaucug caauuacuuu                                                   20


<210>  17224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17224
cuguuuugcc uacugggcag                                                   20


<210>  17225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17225
gugggcauca cccuauaaag                                                   20


<210>  17226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17226
uauugcauaa acagaucuuc                                                   20


<210>  17227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17227
ucaaaugguu aauuccccca                                                   20


<210>  17228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17228
gcguccucaa augguuaauu                                                   20


<210>  17229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17229
ccagagauuc cauccucaca                                                   20


<210>  17230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17230
gguuuuuguu ugaccuugug                                                   20


<210>  17231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17231
aacaaaaacc agacccggau                                                   20


<210>  17232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17232
gaaucccggg guucugcaca                                                   20


<210>  17233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17233
cuccaauugu gcagaacccc                                                   20


<210>  17234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17234
ggcaauggga auauacggau                                                   20


<210>  17235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17235
ugacagcccc aaagcucuca                                                   20


<210>  17236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17236
cgacaacaaa cuaugaaugg                                                   20


<210>  17237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17237
gaacuauuaa auugguuuuu                                                   20


<210>  17238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17238
aagaacaaua ugucugaacu                                                   20


<210>  17239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17239
uagucucaug guuuuuuuuu                                                   20


<210>  17240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17240
caugguuuuu uuuuuauauu                                                   20


<210>  17241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17241
ccaaacuuuc agauugaagc                                                   20


<210>  17242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17242
gagguuuguc uggaaagacc                                                   20


<210>  17243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17243
ggaaagaccu gccagcacau                                                   20


<210>  17244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17244
uuccagacaa accucagacc                                                   20


<210>  17245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17245
auuaauaaua auaaaaaagc                                                   20


<210>  17246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17246
uccuauguuc cucuccaaac                                                   20


<210>  17247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17247
uagaaugaaa gcuguuagaa                                                   20


<210>  17248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17248
aaucuacacu ucacauaaaa                                                   20


<210>  17249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17249
cuaacaaaau gcacuuuuug                                                   20


<210>  17250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17250
cauauggggg aggggcaguu                                                   20


<210>  17251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17251
gagaauuaga gauuuuguua                                                   20


<210>  17252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17252
guuucuuuuu uaaauuauuc                                                   20


<210>  17253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17253
accuucucaa acgugcaauu                                                   20


<210>  17254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17254
ugauaaacaa agcuaagcag                                                   20


<210>  17255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17255
cuggguugau augauaaagu                                                   20


<210>  17256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17256
acuuuaucau aucaacccag                                                   20


<210>  17257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17257
ucggugucaa cuaugucaga                                                   20


<210>  17258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17258
acuaugucag agaccuguaa                                                   20


<210>  17259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17259
gagaccugua agaacauuca                                                   20


<210>  17260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17260
cugacauagu ugacaccgag                                                   20


<210>  17261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17261
ccaugaaccc aaacuuggag                                                   20


<210>  17262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17262
ggcauccagg acccagugga                                                   20


<210>  17263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17263
uggaugccag accaucaaca                                                   20


<210>  17264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17264
uguggaagcc uaggauaugg                                                   20


<210>  17265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17265
gaguuuucuu cucuuaaaga                                                   20


<210>  17266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17266
agggaggaga ggaugccucg                                                   20


<210>  17267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17267
guuuauaaga aaaacgaggc                                                   20


<210>  17268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17268
gcaauaauca cccuuugcca                                                   20


<210>  17269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17269
uguugucaug ccuaucaccg                                                   20


<210>  17270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17270
ugccuaucac cgucacuguu                                                   20


<210>  17271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17271
cuguucaguu ucaguucagg                                                   20


<210>  17272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17272
ucaucauucc aggggccugg                                                   20


<210>  17273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17273
aaaaaugcuu ccagacgacc                                                   20


<210>  17274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17274
ggaagcauuu uuugacgagu                                                   20


<210>  17275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17275
ucuggaagca uuuuuugacg                                                   20


<210>  17276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17276
guucaauacc aggugcuuuu                                                   20


<210>  17277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17277
cauguugagg ggaccgaaga                                                   20


<210>  17278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17278
ccucaacaug ugacacaguu                                                   20


<210>  17279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17279
ucgguccccu caacauguga                                                   20


<210>  17280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17280
auguugcgga gugggucaga                                                   20


<210>  17281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17281
gaguccaggg gagggacuca                                                   20


<210>  17282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17282
aggggaggga cucacauaca                                                   20


<210>  17283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17283
cuccccugga cucugaccca                                                   20


<210>  17284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17284
gacuggggaa cuggcaauag                                                   20


<210>  17285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17285
gacuuguaug ugagucccuc                                                   20


<210>  17286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17286
gggaggugcc ccaaagcggg                                                   20


<210>  17287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17287
cuccacugug cuucagcuac                                                   20


<210>  17288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17288
gcaaagggag guuggggcaa                                                   20


<210>  17289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17289
ggggagaacc uggaaugucg                                                   20


<210>  17290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17290
ucauucacag ccuugaccug                                                   20


<210>  17291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17291
uucacagccu ugaccugaau                                                   20


<210>  17292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17292
aggcugugaa ugacgacauu                                                   20


<210>  17293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17293
cccagcaccc cuacuccaaa                                                   20


<210>  17294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17294
gcagaggaag uggcccauau                                                   20


<210>  17295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17295
aaaucauuuc auuugcauau                                                   20


<210>  17296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17296
auuaugaaag agaagauggu                                                   20


<210>  17297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17297
acucuuugaa ugcuucuaua                                                   20


<210>  17298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17298
aauuauagaa gcauucaaag                                                   20


<210>  17299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17299
aagaaccuaa uucauccuuc                                                   20


<210>  17300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17300
agggguuaga gguaaaaacu                                                   20


<210>  17301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17301
uaccuuuugg caaauugggu                                                   20


<210>  17302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17302
aagccugccc acuauacaau                                                   20


<210>  17303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17303
uguauuauuc auccuuguuu                                                   20


<210>  17304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17304
ugcuaaaaac cagcucacca                                                   20


<210>  17305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17305
cuccagcccu guaaaaacag                                                   20


<210>  17306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17306
uacuuuucua guucuaucca                                                   20


<210>  17307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17307
cauuuuucau acuguuauuu                                                   20


<210>  17308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17308
uacaggagga gauuuuguuu                                                   20


<210>  17309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17309
agggcaugga gcaugauugg                                                   20


<210>  17310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17310
guuuuacacg ccuggaaugu                                                   20


<210>  17311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17311
cuccacccuc ccaccccucu                                                   20


<210>  17312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17312
uuaaaugccu ucuucuuagc                                                   20


<210>  17313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17313
aagcagccuu cauucucaag                                                   20


<210>  17314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17314
guuaaaauuu uuuuugcugu                                                   20


<210>  17315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17315
gacuuuagaa aaauguuagg                                                   20


<210>  17316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17316
gaccauaggu guucaauuuu                                                   20


<210>  17317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17317
gauauuccua acauuuuucu                                                   20


<210>  17318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17318
uaauuaagaa uggaaguaag                                                   20


<210>  17319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17319
uacauauuca ugucauacca                                                   20


<210>  17320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17320
uaccacaggg ucaaggccaa                                                   20


<210>  17321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17321
aggccaaaug ccaaagaguc                                                   20


<210>  17322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17322
ugacacaaaa aaaauaccuu                                                   20


<210>  17323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17323
cgacucuuug gcauuuggcc                                                   20


<210>  17324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17324
uuuauuuuua ucuucuuuug                                                   20


<210>  17325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17325
ucacacucaa auugccauau                                                   20


<210>  17326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17326
guuagcaacu cuuuuacuua                                                   20


<210>  17327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17327
ugcccauuau uuuaaaauaa                                                   20


<210>  17328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17328
uaggcaauga aauaaagcag                                                   20


<210>  17329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17329
guuucauguc uguuuguuuu                                                   20


<210>  17330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17330
guuuguuuua cuaauuugaa                                                   20


<210>  17331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17331
aaucuguaau aucugaaacc                                                   20


<210>  17332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17332
uggaggccuu aggucuuuaa                                                   20


<210>  17333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17333
auagguauca ucuaagcccc                                                   20


<210>  17334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17334
auuugaaaaa cggugugggg                                                   20


<210>  17335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17335
aaauagaauc auaaguaguu                                                   20


<210>  17336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17336
ugcccuaugc uaucuuuuaa                                                   20


<210>  17337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17337
caugagguca ggaguucaag                                                   20


<210>  17338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17338
ggaguucaag accagccugg                                                   20


<210>  17339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17339
ugaacuccug accucaugug                                                   20


<210>  17340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17340
uaaaaauuug gucagagcua                                                   20


<210>  17341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17341
gagcuaagcu uggaauguua                                                   20


<210>  17342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17342
gauccugcaa gcgaauucuc                                                   20


<210>  17343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17343
uuuuaauggu ugaacagaag                                                   20


<210>  17344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17344
uauuucugcc uccagggcuu                                                   20


<210>  17345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17345
ccaucuuugg caucaaaaag                                                   20


<210>  17346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17346
uuggaaagag auaagggaug                                                   20


<210>  17347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17347
uaaaaaaaua acauugcaaa                                                   20


<210>  17348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17348
cugaacaagu ggcagaagcc                                                   20


<210>  17349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17349
auuuaaaugu gcugcaccau                                                   20


<210>  17350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17350
ggucauugaa guaaacauuc                                                   20


<210>  17351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17351
uugaaguaaa cauucauuga                                                   20


<210>  17352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17352
gucaguuacc cagcaaggcu                                                   20


<210>  17353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17353
guuacccagc aaggcugcag                                                   20


<210>  17354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17354
uugcuuuugc caggagcaua                                                   20


<210>  17355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17355
uucuuauagc caacaccuua                                                   20


<210>  17356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17356
aaaggcgauu gcagcauaac                                                   20


<210>  17357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17357
ccccacuuua uucucauggg                                                   20


<210>  17358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17358
uccugaggua ggaaugcaaa                                                   20


<210>  17359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17359
auuacugaga gggagaaaaa                                                   20


<210>  17360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17360
cuggcaagcc cacagcaguu                                                   20


<210>  17361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17361
gcagguguag accccaaaug                                                   20


<210>  17362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17362
acaccugcug accaaaauau                                                   20


<210>  17363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17363
uaaaccacug uucauuuggg                                                   20


<210>  17364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17364
gaacuacuaa agcuugagau                                                   20


<210>  17365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17365
guuagagaau cugucugaac                                                   20


<210>  17366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17366
cuuuccucuu uuguuuggac                                                   20


<210>  17367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17367
aaacaaaaga ggaaagagac                                                   20


<210>  17368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17368
gcaacaucuc caggggaaaa                                                   20


<210>  17369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17369
auccaucucu uuuuguuuuu                                                   20


<210>  17370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17370
gcacuuacag gucuauuucu                                                   20


<210>  17371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17371
auuucuggau gcuuuagaau                                                   20


<210>  17372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17372
ugguggcaag ccaacuucuc                                                   20


<210>  17373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17373
acaacauaac uacauauucu                                                   20


<210>  17374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17374
ucuuugcuug uccuuuagca                                                   20


<210>  17375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17375
uuuagcacaa gggcgagcag                                                   20


<210>  17376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17376
uacgcugcuc gcccuugugc                                                   20


<210>  17377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17377
uuguccuacg cugcucgccc                                                   20


<210>  17378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17378
uugucugugc cgccgccgug                                                   20


<210>  17379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17379
gugccgccgc cgugggccgg                                                   20


<210>  17380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17380
gcaggaagcg ggcgccaucg                                                   20


<210>  17381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17381
agcucaggcc gcacgauggc                                                   20


<210>  17382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17382
caaaggaaag ugguuaccgu                                                   20


<210>  17383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17383
cuccugauca uaaagaagac                                                   20


<210>  17384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17384
ucuuuaugau caggagagac                                                   20


<210>  17385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17385
aaaucuauau auaaauauac                                                   20


<210>  17386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17386
ggagccaaag auauccucca                                                   20


<210>  17387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17387
uccucaagga gccaauggcg                                                   20


<210>  17388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17388
ucccaguggg gaagcccuuu                                                   20


<210>  17389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17389
cccgugagcc aggagcccaa                                                   20


<210>  17390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17390
cgcggcggag agauuauuac                                                   20


<210>  17391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17391
uauccuaaga gcuauuuuag                                                   20


<210>  17392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17392
ccggcuuccc uucccuccag                                                   20


<210>  17393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17393
ugggcugggg agcacugucc                                                   20


<210>  17394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17394
cuuccaaagg cugcugaugg                                                   20


<210>  17395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17395
gccuucagcu gcccucccau                                                   20


<210>  17396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17396
ccagacuucc cggcauaauu                                                   20


<210>  17397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17397
ggggaccuuc ucucaagaac                                                   20


<210>  17398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17398
gaaauggcag gugaccuaag                                                   20


<210>  17399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17399
ccugccauuu cagacaggga                                                   20


<210>  17400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17400
cugauccucu ccaaaucgau                                                   20


<210>  17401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17401
gauggagagg gacgcaugaa                                                   20


<210>  17402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17402
cucuccaucu gacauggcag                                                   20


<210>  17403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17403
cagcucccca ccacguucca                                                   20


<210>  17404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17404
caguguauuc gccuucuggu                                                   20


<210>  17405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17405
uacugugaaa aaacuuagcg                                                   20


<210>  17406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17406
gagaaacaga ugugaugaca                                                   20


<210>  17407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17407
ucacaucugu uucucugacu                                                   20


<210>  17408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17408
gagagaggua ugaagaugug                                                   20


<210>  17409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17409
aagaaaaugu ucuaccauaa                                                   20


<210>  17410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17410
uccagaaauc uuccagggag                                                   20


<210>  17411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17411
gcucuugagc cacugaaauc                                                   20


<210>  17412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17412
aagaguuugc ugagaggaau                                                   20


<210>  17413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17413
agguucugac acauuccucu                                                   20


<210>  17414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17414
gaaccuggac aguaagucaa                                                   20


<210>  17415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17415
gacugaaaau aguggccaac                                                   20


<210>  17416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17416
gacacucccu uuuacaaaug                                                   20


<210>  17417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17417
ccuaugcaua gcuaagaaua                                                   20


<210>  17418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17418
cucugugggu uguggguaga                                                   20


<210>  17419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17419
caaacccuga accaucuacc                                                   20


<210>  17420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17420
aauauaccua accuauugaa                                                   20


<210>  17421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17421
gcagaucagc aauaauaucu                                                   20


<210>  17422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17422
ugaggaaagg gcauuccaag                                                   20


<210>  17423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17423
aaacagugag gagggagcca                                                   20


<210>  17424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17424
ccuccacaga guuucucucc                                                   20


<210>  17425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17425
gccuucaaag aucuuacauu                                                   20


<210>  17426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17426
gguucauugc uauucuccag                                                   20


<210>  17427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17427
uggguuuuuc uucgauggga                                                   20


<210>  17428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17428
ucagguccug gguuuuucuu                                                   20


<210>  17429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17429
aauuagccuu uuucacagac                                                   20


<210>  17430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17430
gugaaaaagg cuaauuugac                                                   20


<210>  17431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17431
uuaggcauuu cuaaguauaa                                                   20


<210>  17432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17432
acugaguucu ucuucucauu                                                   20


<210>  17433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17433
ccccaguuaa aauggcuuuu                                                   20


<210>  17434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17434
uuuugauaaa agccauuuua                                                   20


<210>  17435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17435
augccuacac uucugaaugg                                                   20


<210>  17436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17436
acuccccugu aaugccacua                                                   20


<210>  17437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17437
cagcagaaau auuuuuuguc                                                   20


<210>  17438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17438
uccaacauuu cagacaaggc                                                   20


<210>  17439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17439
gaaauguugg aagacaaaaa                                                   20


<210>  17440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17440
cugagacaca gcuguggauc                                                   20


<210>  17441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17441
cagagaccug guucuuuacg                                                   20


<210>  17442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17442
aaggcaugag ggggauauca                                                   20


<210>  17443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17443
caaaaagaua uggccauggc                                                   20


<210>  17444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17444
uugaguaauu ccaaaauaag                                                   20


<210>  17445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17445
uauuuuggaa uuacucaaug                                                   20


<210>  17446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17446
auaguaacac acggacaaga                                                   20


<210>  17447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17447
aaauucccau ucccucauca                                                   20


<210>  17448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17448
aaaggagugg guuaccaaaa                                                   20


<210>  17449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17449
augugaccua aggaucauug                                                   20


<210>  17450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17450
cauagaccuu cuuggaggca                                                   20


<210>  17451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17451
gcaagauuaa ugaacuuguu                                                   20


<210>  17452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17452
ggauauaaag uuaaucaaug                                                   20


<210>  17453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17453
cuaauucacu aaucauugau                                                   20


<210>  17454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17454
uuuugguaga gcguggucac                                                   20


<210>  17455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17455
uuuucuuucu ccaugcauga                                                   20


<210>  17456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17456
acaaacagca auauucccuc                                                   20


<210>  17457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17457
uaaccuccag aaccucagaa                                                   20


<210>  17458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17458
cauucugagg uucuggaggu                                                   20


<210>  17459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17459
uuguagaugu aauuauuuaa                                                   20


<210>  17460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17460
uuuguuaugg cagcgcuagg                                                   20


<210>  17461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17461
cuuacaacaa agaauuauca                                                   20


<210>  17462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17462
gauaauucuu uguuguaaga                                                   20


<210>  17463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17463
ucaaacuauu cacauuuuga                                                   20


<210>  17464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17464
aaauuccaca ggaaggauuu                                                   20


<210>  17465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17465
cacagcaccc ugugcucaga                                                   20


<210>  17466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17466
ccaucuucaa aaugucagua                                                   20


<210>  17467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17467
guaacuauuu uuugacacgg                                                   20


<210>  17468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17468
agagagaggg agaaugaaaa                                                   20


<210>  17469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17469
cuaguaguug gauaaauggu                                                   20


<210>  17470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17470
acucagcccu ccuauucucu                                                   20


<210>  17471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17471
ugagcgagga ccauucagag                                                   20


<210>  17472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17472
ucgcucagga cucugcucag                                                   20


<210>  17473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17473
uuguugcuuc uuguguggau                                                   20


<210>  17474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17474
auucucucca uuccaacugc                                                   20


<210>  17475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17475
cccaacuggg ggucaauucu                                                   20


<210>  17476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17476
uccaugauca uguucugcua                                                   20


<210>  17477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17477
aucccacuuu caagaggagg                                                   20


<210>  17478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17478
cuaggucuau cccacuuuca                                                   20


<210>  17479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17479
cauaaccuuu gccauauucu                                                   20


<210>  17480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17480
caaggaauaa gagaagaaaa                                                   20


<210>  17481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17481
uucuuuuuca guagagaugg                                                   20


<210>  17482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17482
ggaacuccug agcucaggug                                                   20


<210>  17483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17483
ccugagcuca ggaguuccgg                                                   20


<210>  17484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17484
gaggugggca ggucaccuga                                                   20


<210>  17485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17485
aauucaguag aaguuauuag                                                   20


<210>  17486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17486
aaguguugua aguagagaac                                                   20


<210>  17487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17487
uacaaagaga uaugucaaag                                                   20


<210>  17488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17488
cuccauuaag cuagaagauc                                                   20


<210>  17489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17489
uccaagaucu ucuagcuuaa                                                   20


<210>  17490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17490
cuauugacuc uacacuccau                                                   20


<210>  17491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17491
aaaaauagcg cuggagaaug                                                   20


<210>  17492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17492
cauguuuuaa acaauuuaua                                                   20


<210>  17493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17493
aaguauucuc acgucucaug                                                   20


<210>  17494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17494
uuugcuaaau aaaugaauuc                                                   20


<210>  17495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17495
aaaugagaac aauaucucag                                                   20


<210>  17496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17496
uuguuaacaa uuagacauga                                                   20


<210>  17497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17497
uggcucuuuu uuuuuuuuuu                                                   20


<210>  17498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17498
agcacuaaug gggaaauaca                                                   20


<210>  17499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17499
uacauuuuuc uuuuguauuu                                                   20


<210>  17500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17500
ggcuggggac acuauuauuu                                                   20


<210>  17501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17501
ccagccagac uggagauucc                                                   20


<210>  17502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17502
ggauaagaua auaguuaccu                                                   20


<210>  17503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17503
uaacacugaa uuuccuggcc                                                   20


<210>  17504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17504
aggaaugaag gggaagaauc                                                   20


<210>  17505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17505
ugaccaagcc cuucaucuuc                                                   20


<210>  17506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17506
agaccgaagu gggccccuug                                                   20


<210>  17507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17507
cacccugccu caccucuggc                                                   20


<210>  17508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17508
cagaaaaucu gcucugacaa                                                   20


<210>  17509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17509
gagcagauuu ucugugacca                                                   20


<210>  17510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17510
agcuggaucu ugucagagca                                                   20


<210>  17511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17511
ucucacuuuc uaggucacau                                                   20


<210>  17512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17512
caucauuucc uagcaucuaa                                                   20


<210>  17513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17513
guuuauauau auuuuaaagc                                                   20


<210>  17514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17514
cuucuaauuu caaugaaggg                                                   20


<210>  17515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17515
caaugaacua aaauaaaccc                                                   20


<210>  17516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17516
guguuuccgg aagauuccag                                                   20


<210>  17517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17517
ucccggaguu cuugaggccc                                                   20


<210>  17518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17518
ggcucagagc ccaagcucuu                                                   20


<210>  17519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17519
agcuaagagc uugggcucug                                                   20


<210>  17520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17520
cccaaaaaag auauauugga                                                   20


<210>  17521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17521
uaaccccuag uaccucagaa                                                   20


<210>  17522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17522
uuaaauaggu aaucaauuua                                                   20


<210>  17523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17523
cucuaggcuc aaaauucauu                                                   20


<210>  17524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17524
cuccaggugc uguccauaaa                                                   20


<210>  17525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17525
ggugggcagg aggaggauuc                                                   20


<210>  17526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17526
ucaaaagagg gcauggaacu                                                   20


<210>  17527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17527
guauauguuc ccuuauuuag                                                   20


<210>  17528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17528
auaaauuuau ugaguaguuc                                                   20


<210>  17529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17529
cugggaagcu uccugauccc                                                   20


<210>  17530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17530
ucugauuaaa caguguuggc                                                   20


<210>  17531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17531
cucacaguuc uggagaccag                                                   20


<210>  17532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17532
ccagaacugu gagagacuaa                                                   20


<210>  17533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17533
caagucccca aacaauaaua                                                   20


<210>  17534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17534
ccaaacaaua auaaaacuuu                                                   20


<210>  17535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17535
agaaaaugaa agccacaaau                                                   20


<210>  17536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17536
aacaaauaac caguacaguc                                                   20


<210>  17537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17537
acuguuuuuu cuuuuuuuua                                                   20


<210>  17538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17538
uauuuuuauc cuuauuuuac                                                   20


<210>  17539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17539
cacuuaauau guagcagauu                                                   20


<210>  17540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17540
aaaaaaaaau aucuuguagg                                                   20


<210>  17541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17541
uggaaaagaa guuggcuauu                                                   20


<210>  17542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17542
uuuauuugcc cccagugaga                                                   20


<210>  17543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17543
ccuaaaucuc cugucuuuua                                                   20


<210>  17544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17544
gugcuuaugu gcucugugau                                                   20


<210>  17545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17545
gcaguuacaa uuucacgucu                                                   20


<210>  17546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17546
ccagauguga agggaagucu                                                   20


<210>  17547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17547
acuuuccuag auguaccuuu                                                   20


<210>  17548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17548
aucuugagag gcauuucuua                                                   20


<210>  17549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17549
auuugaguuu ccaaggauga                                                   20


<210>  17550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17550
uacuuaaaac aaccuuucac                                                   20


<210>  17551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17551
ucgcagcauu uucuccucau                                                   20


<210>  17552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17552
cauauucugu aacagaaugg                                                   20


<210>  17553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17553
agaauaaauu gccuuucuca                                                   20


<210>  17554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17554
ccugccugcc gcucuuuggg                                                   20


<210>  17555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17555
ccgggcagcu ccugcugcau                                                   20


<210>  17556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17556
uuaaaacacc uacagauaua                                                   20


<210>  17557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17557
aaaguauugu cuuuaaaaca                                                   20


<210>  17558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17558
uaauuuuagc ugucaaaagu                                                   20


<210>  17559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17559
gucaguuucu cuguuccuuu                                                   20


<210>  17560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17560
guuucucugu uccuuuucgu                                                   20


<210>  17561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17561
augaucccau ggcaugugca                                                   20


<210>  17562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17562
uuguuacuca gagcuguuuu                                                   20


<210>  17563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17563
uuuuaggaga uaauauagua                                                   20


<210>  17564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17564
gaaagcugaa ggccacaagg                                                   20


<210>  17565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17565
ccuggcuuuu aguuaaaaag                                                   20


<210>  17566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17566
cacagcgagg cagaagccgg                                                   20


<210>  17567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17567
cuuaaccugc cugcgucuca                                                   20


<210>  17568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17568
cagugccuuc aucucuaaaa                                                   20


<210>  17569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17569
uugcacacuu gggguucuua                                                   20


<210>  17570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17570
aaagaaggca uggauaaaac                                                   20


<210>  17571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17571
uguacugggc ugcucugaaa                                                   20


<210>  17572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17572
uuaauaacua uuuaggcagc                                                   20


<210>  17573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17573
agagucauua auaacuauuu                                                   20


<210>  17574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17574
ucaaaaucug uuuguguuuu                                                   20


<210>  17575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17575
caccagggua caaguucucu                                                   20


<210>  17576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17576
acauccaauc caccuccacu                                                   20


<210>  17577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17577
ucauacaaau cauaaaaaua                                                   20


<210>  17578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17578
aaaauccaag gggagggaau                                                   20


<210>  17579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17579
agaaagaaaa cuuauacccc                                                   20


<210>  17580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17580
uuagaaagau gcaaaucaaa                                                   20


<210>  17581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17581
gaauuuccuu cguuuuuaag                                                   20


<210>  17582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17582
aguaaaagaa cugaucaaua                                                   20


<210>  17583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17583
uaacaaauau ugaucaguuc                                                   20


<210>  17584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17584
ugucuaagua ggacuucaag                                                   20


<210>  17585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17585
aaguaggacu ucaaggaggc                                                   20


<210>  17586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17586
uacuuagaca ugacucucuu                                                   20


<210>  17587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17587
auguggcaau aauugaugag                                                   20


<210>  17588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17588
cugagugagu gaugaaugaa                                                   20


<210>  17589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17589
ggguaaguca cugagugagu                                                   20


<210>  17590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17590
ugcaagcucc auucauggua                                                   20


<210>  17591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17591
gugaauuugc cuauucuagg                                                   20


<210>  17592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17592
gguuuauuuu acugagcgug                                                   20


<210>  17593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17593
uuuguauuau cuucuuugaa                                                   20


<210>  17594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17594
auucaaguuc uuuugcccau                                                   20


<210>  17595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17595
aggaaauaca aaaauauaaa                                                   20


<210>  17596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17596
cugcaugcuu ggugagaacc                                                   20


<210>  17597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17597
cacugugcuu agcauuaugc                                                   20


<210>  17598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17598
ucuuuucagu uuuuuuuuuu                                                   20


<210>  17599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17599
uuaauaaaac aaauugaaug                                                   20


<210>  17600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17600
aauugcagag agagcccaau                                                   20


<210>  17601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17601
uggagaaaug cuugcaaagg                                                   20


<210>  17602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17602
auuccaccca gcaugguucc                                                   20


<210>  17603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17603
caaccauccu gaagauucag                                                   20


<210>  17604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17604
gaaucuucag gaugguugug                                                   20


<210>  17605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17605
uuggucaaag guaaccauua                                                   20


<210>  17606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17606
aagguaacca uuauccuggg                                                   20


<210>  17607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17607
caggauaaug guuaccuuug                                                   20


<210>  17608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17608
ccacugaaaa cagguuccuc                                                   20


<210>  17609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17609
gauggagaga ugaaauucuu                                                   20


<210>  17610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17610
caccuccugg gucuggaagc                                                   20


<210>  17611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17611
ggaagcugca cgggcugccu                                                   20


<210>  17612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17612
cagcuacuug ggaggcugag                                                   20


<210>  17613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17613
caaaaguuuc ucucuuaucc                                                   20


<210>  17614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17614
cccuucucaa agagaagcca                                                   20


<210>  17615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17615
ggggauguga agauaaauug                                                   20


<210>  17616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17616
cauuaguugg aacauagaag                                                   20


<210>  17617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17617
caaacuuggu aguagcuuuu                                                   20


<210>  17618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17618
ucaugcagga uacaaaagcu                                                   20


<210>  17619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17619
uucgugcaca uuguaguuga                                                   20


<210>  17620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17620
ucaacuacaa ugugcacgaa                                                   20


<210>  17621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17621
ugggucaacu guacucucug                                                   20


<210>  17622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17622
acuguacucu cugugccucu                                                   20


<210>  17623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17623
uaguuccugc uuuccuuaga                                                   20


<210>  17624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17624
uuucagaaca caaccaacag                                                   20


<210>  17625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17625
uggaauagaa augagaccuc                                                   20


<210>  17626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17626
cauuucuauu ccaggacugg                                                   20


<210>  17627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17627
ccuaguagca cuuguacuua                                                   20


<210>  17628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17628
aagcugauga uauucauuca                                                   20


<210>  17629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17629
uggagugaua cgugcuguug                                                   20


<210>  17630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17630
acagcacgua ucacuccagg                                                   20


<210>  17631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17631
guugaagguc aggcuugaag                                                   20


<210>  17632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17632
ggcuugaaga gcuuuuuugg                                                   20


<210>  17633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17633
uuuaaaccau gacagaaaag                                                   20


<210>  17634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17634
ugguuuaaaa gacagaauga                                                   20


<210>  17635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17635
ggcucucugc ucuccuggcu                                                   20


<210>  17636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17636
uuacugagcu gccaccugga                                                   20


<210>  17637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17637
agguggcagc ucaguaagga                                                   20


<210>  17638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17638
ucucccugca ggaccuuggc                                                   20


<210>  17639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17639
ugcagggaga agacacagcc                                                   20


<210>  17640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17640
ugugugugcc aagguccugc                                                   20


<210>  17641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17641
agucuugugu gugccaaggu                                                   20


<210>  17642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17642
caucucaggc ccuaauccca                                                   20


<210>  17643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17643
aagguuaauu acuuuccaga                                                   20


<210>  17644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17644
ccagccagcc cuucuccaca                                                   20


<210>  17645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17645
auauuguucu augacaauua                                                   20


<210>  17646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17646
uagaacaaua uagacucuuu                                                   20


<210>  17647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17647
aucccuuuac uguuaauugu                                                   20


<210>  17648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17648
cugugcacca gaagaguggu                                                   20


<210>  17649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17649
ucuaauaaug cccccguuuu                                                   20


<210>  17650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17650
ccuuucaaag ugcuuggggu                                                   20


<210>  17651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17651
auucucacau ugcuauaagg                                                   20


<210>  17652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17652
cugcucuugu cuugccccca                                                   20


<210>  17653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17653
guuuccuguc ucugcucuug                                                   20


<210>  17654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17654
cuuguaauuc ucaaaacugg                                                   20


<210>  17655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17655
ggaauauuug uauuauacaa                                                   20


<210>  17656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17656
guucuggcuu uagcacugaa                                                   20


<210>  17657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17657
uuauuuucau agguuuauua                                                   20


<210>  17658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17658
ucugaaagau ggguaacagg                                                   20


<210>  17659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17659
cugugugacu cccaggcuuc                                                   20


<210>  17660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17660
cacagugacu gauuucaguu                                                   20


<210>  17661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17661
guggagagca uaaguucuac                                                   20


<210>  17662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17662
aauucaccua ggauauucuu                                                   20


<210>  17663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17663
cagcaaaacc ucuucuuguu                                                   20


<210>  17664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17664
guuccugcca auaauucagu                                                   20


<210>  17665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17665
ccauuauuuc acaggcagga                                                   20


<210>  17666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17666
cuauuguauc uugaguuugg                                                   20


<210>  17667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17667
aguuagagau cuccugugca                                                   20


<210>  17668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17668
gcugauucug accaugcugg                                                   20


<210>  17669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17669
gaaucagcag acagaggcac                                                   20


<210>  17670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17670
acacuuaaga ugcuuaucaa                                                   20


<210>  17671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17671
gucuacacuu aagaugcuua                                                   20


<210>  17672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17672
ugcuaagcac aggcacguuu                                                   20


<210>  17673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17673
cccucuuccu ucagggguac                                                   20


<210>  17674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17674
ccaguuuuag gggaaaaaau                                                   20


<210>  17675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17675
ucuaaacaau uuuuuccccu                                                   20


<210>  17676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17676
uggcuugucc ucuaaacaau                                                   20


<210>  17677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17677
cucuggcaag agaauauccu                                                   20


<210>  17678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17678
uaauaguaga auuuugagca                                                   20


<210>  17679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17679
accgaggagg aaggagcugg                                                   20


<210>  17680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17680
accuaagaau cuaagaaaag                                                   20


<210>  17681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17681
cauuguucag cuaaugcuuu                                                   20


<210>  17682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17682
aggggaagaa aacagaaugg                                                   20


<210>  17683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17683
ugggguuucu ccuauugaua                                                   20


<210>  17684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17684
uuauggagcu auucccuagc                                                   20


<210>  17685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17685
uaauguuuuc uagcaguuag                                                   20


<210>  17686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17686
ggcuggauac uguagcuaaa                                                   20


<210>  17687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17687
uagaaaggga agaugaaaug                                                   20


<210>  17688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17688
ugcuucuccc aucuccucuc                                                   20


<210>  17689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17689
aaagugggca ucugucuaca                                                   20


<210>  17690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17690
acauuuggga gaagcucuag                                                   20


<210>  17691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17691
gcaugguuag guuugagcag                                                   20


<210>  17692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17692
ggaagcuccc ugggacaccc                                                   20


<210>  17693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17693
cagggagcuu ccugaccaca                                                   20


<210>  17694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17694
gggaggcuuu cugcaaagaa                                                   20


<210>  17695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17695
ucuuugcaga aagccucccu                                                   20


<210>  17696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17696
cugcaguauc acaccaacuc                                                   20


<210>  17697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17697
cagcacacac acacagaagu                                                   20


<210>  17698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17698
cuuucuucug auaaugguuu                                                   20


<210>  17699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17699
guuuaacuuu gaacuuuaga                                                   20


<210>  17700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17700
cauggcacag auggcgaaau                                                   20


<210>  17701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17701
uucccuguuu cuaacucaga                                                   20


<210>  17702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17702
gaggaaggug ggugaguauc                                                   20


<210>  17703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17703
cuguggauuc uugggccuug                                                   20


<210>  17704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17704
uugggaaggg agaggaaaua                                                   20


<210>  17705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17705
ucuaaugaaa aagcccugua                                                   20


<210>  17706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17706
ugggaguacc caacacaugc                                                   20


<210>  17707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17707
cgugagaucu gaugguuuua                                                   20


<210>  17708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17708
aauuaaaccu cuuucuuuug                                                   20


<210>  17709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17709
cgggcaauug ugucuuuguc                                                   20


<210>  17710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17710
uugucagcag cgugaaaacg                                                   20


<210>  17711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17711
gcagcgugaa aacggacuaa                                                   20


<210>  17712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17712
aaucccagac aacccaacac                                                   20


<210>  17713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17713
gggauuagac caagagggag                                                   20


<210>  17714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17714
uuuuugcaaa ggugucaacc                                                   20


<210>  17715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17715
accuccuuug uuuuguuguu                                                   20


<210>  17716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17716
uuaacagaga gacagagaga                                                   20


<210>  17717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17717
cucuguuaau gaccacccuu                                                   20


<210>  17718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17718
gccucuucuc ucugucucuc                                                   20


<210>  17719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17719
ucuagguuca ccucaagagg                                                   20


<210>  17720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17720
aguaauuuuu aauuccaauu                                                   20


<210>  17721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17721
gaagaucuaa auguagguca                                                   20


<210>  17722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17722
gaauucugaa ucagcagcag                                                   20


<210>  17723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17723
ucugcauaaa acuucauauu                                                   20


<210>  17724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17724
gccacuuucc cauaaagcuu                                                   20


<210>  17725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17725
ucuccuggcg aguggaaaac                                                   20


<210>  17726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17726
ccuggcgagu ggaaaacuua                                                   20


<210>  17727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17727
aaaaccgcug auccaucucu                                                   20


<210>  17728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17728
acagagauuu aauuaacucc                                                   20


<210>  17729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17729
uggcugggag uuaauuaaau                                                   20


<210>  17730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17730
caacuuucug ggaucauuuc                                                   20


<210>  17731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17731
gucccugccg guaaggccag                                                   20


<210>  17732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17732
cugccgguaa ggccagaaga                                                   20


<210>  17733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17733
ugcaucuucu ggccuuaccg                                                   20


<210>  17734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17734
uuuuucauuu uuaaaaacug                                                   20


<210>  17735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17735
cuuggcuuuc uccuacaaaa                                                   20


<210>  17736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17736
gcuuacucaa uuaugaucac                                                   20


<210>  17737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17737
ggaacauaga agggaaacuc                                                   20


<210>  17738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17738
ucugugagcu ugauugaugu                                                   20


<210>  17739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17739
gccuccccaa guccaaucag                                                   20


<210>  17740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17740
aaucagcuac aaugacaugg                                                   20


<210>  17741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17741
uuguagcuga uuggacuugg                                                   20


<210>  17742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17742
gaguuacuac cuaacaaaag                                                   20


<210>  17743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17743
gggcacacag aaagcauuuu                                                   20


<210>  17744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17744
acucagaaga auaaaacuug                                                   20


<210>  17745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17745
acuggcagga ucuuauuuua                                                   20


<210>  17746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17746
aguuuuauuc uucugagucg                                                   20


<210>  17747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17747
ucuaaugguu uugcauguca                                                   20


<210>  17748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17748
ccaagggaug ugcuucucuu                                                   20


<210>  17749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17749
acauuuauau ugggaaaaau                                                   20


<210>  17750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17750
cuuuuaucuu gaucacuagu                                                   20


<210>  17751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17751
aacauggcug cucaagucca                                                   20


<210>  17752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17752
uuaaagagaa aaguaugcac                                                   20


<210>  17753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17753
cccuugcagu gugguguggc                                                   20


<210>  17754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17754
uccucaaagg aacuugaguu                                                   20


<210>  17755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17755
cuagaaaugg acaugguaau                                                   20


<210>  17756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17756
auuucuagug acuucacugg                                                   20


<210>  17757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17757
gaauccaacc acauggcuca                                                   20


<210>  17758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17758
cagucuugga cucugcuucu                                                   20


<210>  17759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17759
uggacucugc uucucucugg                                                   20


<210>  17760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17760
aagacugaga cugagccaug                                                   20


<210>  17761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17761
cagagagaag cagaguccaa                                                   20


<210>  17762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17762
cugacuggcc uggagcuggg                                                   20


<210>  17763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17763
gagacaccau gauuggcuca                                                   20


<210>  17764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17764
ccaccaaaaa ucauguugac                                                   20


<210>  17765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17765
ggcagggacc uggcaggaau                                                   20


<210>  17766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17766
cugccugaca uugccauccu                                                   20


<210>  17767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17767
gaugcuucug cauggguugu                                                   20


<210>  17768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17768
ugucguguuu cuggagaaag                                                   20


<210>  17769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17769
uguuucugga gaaagccucu                                                   20


<210>  17770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17770
ucagaggcuu ucuccagaaa                                                   20


<210>  17771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17771
ggggcacagc ucugcaggca                                                   20


<210>  17772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17772
cccaucuccu acaccuaguc                                                   20


<210>  17773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17773
uguuaaugag cauaaucacg                                                   20


<210>  17774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17774
ucaggcauac uaagaauaac                                                   20


<210>  17775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17775
auaagaacua aaauuaaucu                                                   20


<210>  17776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17776
ccauugguga ucagcgugua                                                   20


<210>  17777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17777
caugcucugc ugaaaccagc                                                   20


<210>  17778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17778
acagaacuug gggaauuagu                                                   20


<210>  17779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17779
cauucuuugc uuuacauuuu                                                   20


<210>  17780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17780
augugaauua aauaucauua                                                   20


<210>  17781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17781
gauucugugc ucaaauccca                                                   20


<210>  17782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17782
cauggauuaa agugaguggu                                                   20


<210>  17783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17783
ucacagguca cauggauuaa                                                   20


<210>  17784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17784
cuuacacagc aucacacggc                                                   20


<210>  17785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17785
gcccccuagu ggucauguca                                                   20


<210>  17786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17786
ugucacacag ugugugcuua                                                   20


<210>  17787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17787
cacagugugu gcuuacgcag                                                   20


<210>  17788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17788
ucugcguaag cacacacugu                                                   20


<210>  17789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17789
aagguuaauc aaacacagau                                                   20


<210>  17790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17790
caacagauuu uuaucuuaac                                                   20


<210>  17791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17791
caauuguucc uguuuaauuu                                                   20


<210>  17792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17792
cggcuacuca ucagaaucac                                                   20


<210>  17793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17793
aguucugaua gaguuuugaa                                                   20


<210>  17794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17794
uuugacagug gauuugaguu                                                   20


<210>  17795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17795
aaagacaaaa auuugccagu                                                   20


<210>  17796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17796
uacccaguuu auccugcaaa                                                   20


<210>  17797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17797
aacacaacau auggccaagg                                                   20


<210>  17798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17798
caugcgccuc auaauugaca                                                   20


<210>  17799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17799
auuaugaggc gcaugagaca                                                   20


<210>  17800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17800
uuaaaagaca auguugaucu                                                   20


<210>  17801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17801
uuuaaugaca gugcuuuggg                                                   20


<210>  17802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17802
cgccagcccu cacacaucca                                                   20


<210>  17803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17803
aacccgaauu uagaauugaa                                                   20


<210>  17804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17804
gaaccgaaca gccccugggc                                                   20


<210>  17805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17805
cugaacagag auccucagca                                                   20


<210>  17806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17806
ggugucccug aacagagauc                                                   20


<210>  17807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17807
ucuaaacccu cauaaugaaa                                                   20


<210>  17808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17808
aucauaaauc aaccggacuu                                                   20


<210>  17809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17809
gguugauuua ugauugacua                                                   20


<210>  17810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17810
guaggaugga guuucccaau                                                   20


<210>  17811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17811
uagguuugga aacuaaggag                                                   20


<210>  17812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17812
gaaaacuaca auaaugaaaa                                                   20


<210>  17813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17813
caaaauacau guuuuaaaag                                                   20


<210>  17814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17814
gguuuugaag ccacaaggua                                                   20


<210>  17815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17815
gcauuugggg uccucaaucu                                                   20


<210>  17816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17816
ucaaucugcc uucacaccuc                                                   20


<210>  17817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17817
cagugcuggu uucagagaca                                                   20


<210>  17818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17818
cugaaaccag cacugagaca                                                   20


<210>  17819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17819
uggcagccca uccagcucug                                                   20


<210>  17820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17820
aacuccgcca gcagaugcag                                                   20


<210>  17821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17821
gccauuggga agggcugcuu                                                   20


<210>  17822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17822
ucacacgaga gagagucagc                                                   20


<210>  17823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17823
uaucuggagc ccaucuucug                                                   20


<210>  17824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17824
gaagaugggc uccagauagg                                                   20


<210>  17825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17825
uucuuucaua ggcucccuga                                                   20


<210>  17826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17826
gggagccuau gaaagaaaga                                                   20


<210>  17827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17827
uucccuugua cuuaaucucc                                                   20


<210>  17828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17828
ucaaauaugu ccacaauuuc                                                   20


<210>  17829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17829
acaauuucuu uaacacuucu                                                   20


<210>  17830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17830
aacacaucau uucgcuguuu                                                   20


<210>  17831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17831
auaaaguuca uggagcccua                                                   20


<210>  17832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17832
ucucauuguu auaggggcca                                                   20


<210>  17833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17833
ccagaugggc ccuuuuugga                                                   20


<210>  17834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17834
uugggagaaa ugccagaguc                                                   20


<210>  17835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17835
aauguuucuc uacuauugga                                                   20


<210>  17836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17836
aauaguagag aaacauugga                                                   20


<210>  17837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17837
cacccagcau uuuacaaaau                                                   20


<210>  17838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17838
cagaucauuc agcuuugauc                                                   20


<210>  17839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17839
uaggaaugua caggggaaau                                                   20


<210>  17840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17840
uuaaggaacu auuuccccug                                                   20


<210>  17841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17841
uuggggagaa aaugggcuaa                                                   20


<210>  17842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17842
aggcauccca ggcuuucaau                                                   20


<210>  17843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17843
ccguaaagac ucugaaauga                                                   20


<210>  17844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17844
uuacggggac uuuuugaaaa                                                   20


<210>  17845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17845
auguugaaag aauaaaguuu                                                   20


<210>  17846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17846
aacaacucaa aagcagcaga                                                   20


<210>  17847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17847
uugaaacacg auuguaaaac                                                   20


<210>  17848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17848
ggccaacaag aaguaauuga                                                   20


<210>  17849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17849
aauaauaggu uugcuugucu                                                   20


<210>  17850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17850
ugagaaaaag accacaggua                                                   20


<210>  17851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17851
uuuucucaug accucuguau                                                   20


<210>  17852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17852
aaucaguaaa acaucuuuuu                                                   20


<210>  17853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17853
aaaagauguu uuacugauuu                                                   20


<210>  17854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17854
uuuuaagugu cagaaauaaa                                                   20


<210>  17855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17855
gaaauaaaag gacgugcucu                                                   20


<210>  17856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17856
uuuuauuucu gacacuuaaa                                                   20


<210>  17857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17857
cuggcaugca gagaggcgau                                                   20


<210>  17858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17858
cguuucuuuu acagcugagu                                                   20


<210>  17859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17859
ugguauuuuu uucccuagag                                                   20


<210>  17860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17860
uaauauugaa ugagacccag                                                   20


<210>  17861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17861
cauucaauau uaugacucua                                                   20


<210>  17862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17862
aucaucuuuu uauuuguauu                                                   20


<210>  17863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17863
cggauuuaau auuacagccu                                                   20


<210>  17864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17864
aacuauagcu caaaccuugg                                                   20


<210>  17865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17865
cuagggacaa uucaggguga                                                   20


<210>  17866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17866
cuagggacca ugaagccauu                                                   20


<210>  17867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17867
ugggugguua aaccguagga                                                   20


<210>  17868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17868
uuauguaucc uacgguuuaa                                                   20


<210>  17869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17869
uuccuuuugg ggauaggauu                                                   20


<210>  17870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17870
aacaagucua ggagcuuuuu                                                   20


<210>  17871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17871
aggagcuuuu uauccauuca                                                   20


<210>  17872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17872
agaaagcugu uucuuugcuu                                                   20


<210>  17873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17873
ccccacaaaa aucugcugaa                                                   20


<210>  17874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17874
auaucuaaaa gucaaaaaua                                                   20


<210>  17875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17875
aaaauaaaag cuccccagcc                                                   20


<210>  17876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17876
acucaaggaa cccaaaauac                                                   20


<210>  17877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17877
cagaaaacuu ccgaaaagga                                                   20


<210>  17878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17878
cuugauuugc uuagaggaga                                                   20


<210>  17879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17879
caaacuucug agcucaagug                                                   20


<210>  17880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17880
ccucccuuua gccuuaguuu                                                   20


<210>  17881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17881
ugucuguggg ccuggguuuc                                                   20


<210>  17882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17882
gugggccugg guuuccucgc                                                   20


<210>  17883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17883
ucacauggcc uucuucccug                                                   20


<210>  17884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17884
cugccucagu cuucacaugg                                                   20


<210>  17885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17885
ccagaagcug gaagaggcau                                                   20


<210>  17886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17886
ccugaugcag cccccacggg                                                   20


<210>  17887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17887
aaaguggcgu ucaaccagcc                                                   20


<210>  17888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17888
uuaggcuggu ugaacgccac                                                   20


<210>  17889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17889
auuagaaacu auccauguac                                                   20


<210>  17890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17890
auuaggaagc agagggagcg                                                   20


<210>  17891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17891
ccgaagaaga uuuagagagg                                                   20


<210>  17892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17892
ggaaaaucag cguauagaac                                                   20


<210>  17893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17893
uagauagcag ucccugauca                                                   20


<210>  17894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17894
cugaucaacc ggaggccaau                                                   20


<210>  17895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17895
ugggauucuc agggaugcuu                                                   20


<210>  17896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17896
agcuaggaaa aggaauugaa                                                   20


<210>  17897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17897
aauuuccauu uaagcuuugc                                                   20


<210>  17898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17898
cuccuggcca gggcuaguaa                                                   20


<210>  17899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17899
cucuacaccu uucaggaaaa                                                   20


<210>  17900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17900
cagcuuugug ccuugcaaag                                                   20


<210>  17901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17901
uuagagaacu caacaugagg                                                   20


<210>  17902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17902
cugaaggaug gugcagggga                                                   20


<210>  17903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence GTCN PAM

<400>  17903
cuaaaucaag gccaauuuuu                                                   20


<210>  17904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17904
ccaacgcagc aucugugcca                                                   20


<210>  17905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17905
ggcucugguu gggggugggg                                                   20


<210>  17906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17906
caucauucgg gcucugguug                                                   20


<210>  17907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17907
gcucuguuca caucauucgg                                                   20


<210>  17908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17908
uugcgugugc agcucccccc                                                   20


<210>  17909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17909
cacaagcaua aacaauccag                                                   20


<210>  17910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17910
ugcgcccuuu cucacaagca                                                   20


<210>  17911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17911
ccuuuaacac ugaugcuggg                                                   20


<210>  17912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17912
agccaauucc aucccuucaa                                                   20


<210>  17913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17913
aucccuucaa gcccaccccc                                                   20


<210>  17914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17914
agcccacccc caccuuugca                                                   20


<210>  17915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17915
agcaauucuc cugccucagc                                                   20


<210>  17916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17916
ccugccucag ccucacaagu                                                   20


<210>  17917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17917
ucauguuggc caggcugguc                                                   20


<210>  17918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17918
agaccagccu ggccaacaug                                                   20


<210>  17919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17919
ggaauuacag ucgugagcca                                                   20


<210>  17920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17920
agaacuuugg gaggccaaag                                                   20


<210>  17921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17921
ggggguuccu uauacuugga                                                   20


<210>  17922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17922
uuauacuugg acagauacau                                                   20


<210>  17923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17923
aauucugacu cugcaacuuc                                                   20


<210>  17924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17924
gacucugcaa cuuccuaguu                                                   20


<210>  17925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17925
uaguuacaug accuugggaa                                                   20


<210>  17926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17926
caaggucaug uaacuaggaa                                                   20


<210>  17927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17927
uugaccuuca gcuugucauc                                                   20


<210>  17928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17928
gcuugucauc ugaagaaaua                                                   20


<210>  17929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17929
gaugacaagc ugaaggucaa                                                   20


<210>  17930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17930
ucagaugaca agcugaaggu                                                   20


<210>  17931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17931
uuuaauccuc uuaaguugcu                                                   20


<210>  17932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17932
uuaauuucau uuaauccucu                                                   20


<210>  17933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17933
auaaaaacug caagguauac                                                   20


<210>  17934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17934
gcuccugugu ccccacuucu                                                   20


<210>  17935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17935
ccccacauga uuugaacaug                                                   20


<210>  17936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17936
aaucaugugg ggagaagugg                                                   20


<210>  17937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17937
uuaacucucc ggaccuccau                                                   20


<210>  17938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17938
cauaugcaag augagaaggu                                                   20


<210>  17939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17939
caucuugcau augagaaaau                                                   20


<210>  17940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17940
acaccguuga guaccuuucc                                                   20


<210>  17941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17941
ucuggcaugg aacaagaugc                                                   20


<210>  17942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17942
augccagagg aaagguacuc                                                   20


<210>  17943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17943
auccuugggc aucuuguucc                                                   20


<210>  17944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17944
ugugccacug gcagggggug                                                   20


<210>  17945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17945
uuauuuccug ugccacuggc                                                   20


<210>  17946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17946
ugggucauuu cuuuauuucc                                                   20


<210>  17947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17947
cuugagacug gcaagugagu                                                   20


<210>  17948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17948
gacucacuug ccagucucaa                                                   20


<210>  17949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17949
aauccaagca aagaggaccu                                                   20


<210>  17950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17950
ucuccuaucc cugagguccu                                                   20


<210>  17951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17951
agugugccuu uccacuccca                                                   20


<210>  17952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17952
acucccauua cuaccuccua                                                   20


<210>  17953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17953
gaaucucuuc uuaggacaau                                                   20


<210>  17954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17954
gaaagccuga cuuaggaggu                                                   20


<210>  17955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17955
uaggacaauu gugagggacu                                                   20


<210>  17956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17956
agcaacccuu ccuccagccu                                                   20


<210>  17957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17957
uccagccuau ccuagauagc                                                   20


<210>  17958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17958
cagugcgcau uaacacuaga                                                   20


<210>  17959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17959
ucccuccacc cagaguaccu                                                   20


<210>  17960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17960
cuccacccag aguaccuucg                                                   20


<210>  17961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17961
acauucugau ccuugaagcc                                                   20


<210>  17962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17962
gauccuugaa gccccagauc                                                   20


<210>  17963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17963
aggaucagaa ugucgaaggu                                                   20


<210>  17964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17964
uacugcuucc aagaagcuca                                                   20


<210>  17965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17965
aagaagcuca uccucaugag                                                   20


<210>  17966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17966
uggaagcagu aggaauugau                                                   20


<210>  17967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17967
uggaugaaau agggaguucc                                                   20


<210>  17968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17968
uccaagaacu caugaggaug                                                   20


<210>  17969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17969
cacucacugg agaauuucaa                                                   20


<210>  17970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17970
ccagugagug ggaacucccu                                                   20


<210>  17971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17971
agaagaauga cucaagcaca                                                   20


<210>  17972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17972
ugaaauucuc cagugagugg                                                   20


<210>  17973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17973
ucuugaaauu cuccagugag                                                   20


<210>  17974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17974
ugagcaugug cuugagucau                                                   20


<210>  17975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17975
ccauguucua uugaauuaaa                                                   20


<210>  17976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17976
auugaauuaa aaaaaaaaaa                                                   20


<210>  17977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17977
auagaacaug gagaaccaau                                                   20


<210>  17978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17978
cacccuacua uuccacccua                                                   20


<210>  17979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17979
acccuaccug gccuaguccc                                                   20


<210>  17980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17980
caggauuagc aggggacuag                                                   20


<210>  17981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17981
aauccuaacu aaacucugcu                                                   20


<210>  17982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17982
cuaauucuau ccuccuucca                                                   20


<210>  17983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17983
auccuccuuc caagcccuuu                                                   20


<210>  17984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17984
aagcccuuua acuccugugu                                                   20


<210>  17985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17985
uguuuuuccc uaggaaucag                                                   20


<210>  17986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17986
cuaggaauca gaaucuccuu                                                   20


<210>  17987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17987
uagggaaaaa caagaaacac                                                   20


<210>  17988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17988
gauuccuagg gaaaaacaag                                                   20


<210>  17989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17989
gucaagggua cacuuggaga                                                   20


<210>  17990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17990
ccaaguguac ccuugacuga                                                   20


<210>  17991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17991
uaaaugcuau ggcaugacag                                                   20


<210>  17992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17992
agagucccuc acucaauaau                                                   20


<210>  17993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17993
augcucgugu guuuuguaca                                                   20


<210>  17994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17994
cauucaaugc ucguguguuu                                                   20


<210>  17995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17995
aguucuggcc uuccagaaac                                                   20


<210>  17996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17996
ggccuuccag aaaccuggau                                                   20


<210>  17997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17997
agaaaccugg aucagcucua                                                   20


<210>  17998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17998
ggaaggccag aacuggaaga                                                   20


<210>  17999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  17999
gaacucugcu uuucccaaau                                                   20


<210>  18000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18000
gaagauguca uagagcugau                                                   20


<210>  18001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18001
caaaucccuu uggccccuug                                                   20


<210>  18002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18002
cauuuaguug ucuggguuuu                                                   20


<210>  18003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18003
uugcaaaaca uuaaauacaa                                                   20


<210>  18004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18004
cauaguucaa aauaauuuug                                                   20


<210>  18005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18005
aaauaauuuu guaauuaaaa                                                   20


<210>  18006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18006
agauuuccuu uacgcaaaua                                                   20


<210>  18007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18007
uuuacgcaaa uacaaauaua                                                   20


<210>  18008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18008
uacauuuuau uacacaaaca                                                   20


<210>  18009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18009
cugcagcugg ugagcaaauu                                                   20


<210>  18010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18010
aagcuccuuu augcccuacu                                                   20


<210>  18011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18011
ugguuggcug cccuuccaua                                                   20


<210>  18012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18012
auaaccuucu ccaguccugc                                                   20


<210>  18013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18013
ccaguccugc cuggagcuga                                                   20


<210>  18014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18014
gcuccaggca ggacuggaga                                                   20


<210>  18015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18015
ucagacacau uuuuagagaa                                                   20


<210>  18016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18016
cuaaaaaugu gucugaggaa                                                   20


<210>  18017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18017
aucuguggua ugccaggccu                                                   20


<210>  18018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18018
acuugguggg agagaaaaua                                                   20


<210>  18019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18019
cucccaccaa guugaaaggc                                                   20


<210>  18020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18020
uagcccauga uauuuucucu                                                   20


<210>  18021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18021
ugcagcugug uccccaacuu                                                   20


<210>  18022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18022
ucucaucuuu agaaugagga                                                   20


<210>  18023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18023
caucuuuaga augaggagau                                                   20


<210>  18024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18024
aaagaugaga agaacgaggc                                                   20


<210>  18025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18025
agggaucugc ccacaccagc                                                   20


<210>  18026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18026
agccucagcu gugcagacau                                                   20


<210>  18027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18027
ugggugcaaa guggcccuca                                                   20


<210>  18028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18028
uuccccuggg gccacaggcc                                                   20


<210>  18029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18029
ccuggggcca caggcccggg                                                   20


<210>  18030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18030
ggcaggcagc ugccucuggg                                                   20


<210>  18031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18031
ugguaaguca agagaagccu                                                   20


<210>  18032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18032
cuugacuuac caggaaaggc                                                   20


<210>  18033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18033
aggccagcac ugcucucacu                                                   20


<210>  18034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18034
aggaugugag ugagagcagu                                                   20


<210>  18035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18035
ggugccaccu gcuucaagga                                                   20


<210>  18036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18036
ccauucuggu gccaccugcu                                                   20


<210>  18037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18037
caagagccuc ugugggggaa                                                   20


<210>  18038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18038
cccacagagg cucuugggaa                                                   20


<210>  18039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18039
ucuccauucc ucucugcccg                                                   20


<210>  18040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18040
ucucugcccg acugcccucc                                                   20


<210>  18041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18041
accugcuguu agaaacagga                                                   20


<210>  18042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18042
aacagcaggu ggaagcaggu                                                   20


<210>  18043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18043
aggucacauc ucuccuguuu                                                   20


<210>  18044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18044
gaaacugagu ccagagagag                                                   20


<210>  18045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18045
gaaucuguag acaaagaggg                                                   20


<210>  18046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18046
ucucucugga cucaguuucu                                                   20


<210>  18047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18047
ucacucaggc agcugcaugc                                                   20


<210>  18048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18048
auggcaagcc acucaacacg                                                   20


<210>  18049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18049
cugagacgug uugaguggcu                                                   20


<210>  18050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18050
cccuucugga ggccgcgucc                                                   20


<210>  18051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18051
ggaggccgcg uccgcacguc                                                   20


<210>  18052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18052
cugagucgag agucuuggcu                                                   20


<210>  18053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18053
cacccuguuc ccugagucga                                                   20


<210>  18054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18054
cagggggagc agccaggaac                                                   20


<210>  18055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18055
uggcugcucc cccugagaag                                                   20


<210>  18056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18056
cugcaccagu ggcgaaggcu                                                   20


<210>  18057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18057
ccacuggugc agagaacuga                                                   20


<210>  18058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18058
ugcaacuguu guaagcagga                                                   20


<210>  18059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18059
cugccugucc ugcuuacaac                                                   20


<210>  18060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18060
ucucuucccu gccuguccug                                                   20


<210>  18061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18061
gcugaccagu guucaggcug                                                   20


<210>  18062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18062
ggcuggaacu gggagucggg                                                   20


<210>  18063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18063
agccugaaca cuggucagcu                                                   20


<210>  18064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18064
ggcccgacuc ccaguuccag                                                   20


<210>  18065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18065
gaccacaaaa aaaagcuauu                                                   20


<210>  18066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18066
cuauuaggga uagagaucag                                                   20


<210>  18067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18067
acaagcucug aucucuaucc                                                   20


<210>  18068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18068
auugagugau ccccacuucu                                                   20


<210>  18069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18069
cucugccugu cuaaauccuc                                                   20


<210>  18070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18070
uugaaaagca gcucagagcu                                                   20


<210>  18071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18071
aagaagagag gauuuagaca                                                   20


<210>  18072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18072
ugaagccuuc cuugccuacg                                                   20


<210>  18073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18073
agaaagaggc agcucugagc                                                   20


<210>  18074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18074
uugccuacga acacccccau                                                   20


<210>  18075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18075
uaggcaagga aggcuucaag                                                   20


<210>  18076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18076
gaggauggag acugcauggg                                                   20


<210>  18077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18077
uucaggaggc aucaaggaac                                                   20


<210>  18078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18078
ggaggcauca aggaacuggg                                                   20


<210>  18079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18079
uugaugccuc cugaaggaaa                                                   20


<210>  18080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18080
gggcugccgc uuagauuacg                                                   20


<210>  18081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18081
agaggagcag gauguucuac                                                   20


<210>  18082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18082
accccuuuag ugcccuccgc                                                   20


<210>  18083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18083
gcugggccgu gggcugcgga                                                   20


<210>  18084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18084
aguuccuccc cccaaaggac                                                   20


<210>  18085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18085
uccccccaaa ggacagcgaa                                                   20


<210>  18086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18086
cuguccuuug gggggaggaa                                                   20


<210>  18087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18087
agagugugug guuggcuucg                                                   20


<210>  18088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18088
ccugucagac aucccucaug                                                   20


<210>  18089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18089
acggggagag gaguguaagg                                                   20


<210>  18090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18090
ggaacuggca ucaggcuuga                                                   20


<210>  18091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18091
agaagcccag ucggcaacuc                                                   20


<210>  18092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18092
guggacucca cacugccuca                                                   20


<210>  18093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18093
cucuuuggcu gccccugaag                                                   20


<210>  18094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18094
ggggcagcca aagagggaaa                                                   20


<210>  18095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18095
acucaacucc uccucuaugg                                                   20


<210>  18096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18096
gacaugugua auuuauccca                                                   20


<210>  18097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18097
gacuggaguu aaucucacau                                                   20


<210>  18098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18098
cagagcugga gggagucccu                                                   20


<210>  18099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18099
gguuuuacuu acucugaccc                                                   20


<210>  18100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18100
cuguuucugg uuuuacuuac                                                   20


<210>  18101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18101
gugaggucca gcaacacagu                                                   20


<210>  18102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18102
aaaugugggc aggggcuucc                                                   20


<210>  18103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18103
agaccguccu ggucaauaau                                                   20


<210>  18104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18104
cucggauuau uauugaccag                                                   20


<210>  18105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18105
uccucguugu gauuuguggc                                                   20


<210>  18106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18106
ucguugugau uuguggcuug                                                   20


<210>  18107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18107
uuaggcaaag uugcaggccc                                                   20


<210>  18108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18108
ccagucugcc cccgccuggc                                                   20


<210>  18109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18109
ugagccucag cuggggccag                                                   20


<210>  18110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18110
acacauguaa uauucccgag                                                   20


<210>  18111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18111
cgaguaguac uuaagcuugu                                                   20


<210>  18112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18112
gcaucauaaa aaauggauuu                                                   20


<210>  18113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18113
cacggugaug uuaacacauc                                                   20


<210>  18114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18114
aaaguuaagu uucucacggu                                                   20


<210>  18115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18115
gcaacauguu accaaacauu                                                   20


<210>  18116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18116
uacacaguua cuuccauaca                                                   20


<210>  18117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18117
auacaagguu caaggugguu                                                   20


<210>  18118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18118
aggugguugg uuauauuuaa                                                   20


<210>  18119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18119
auauuuaaau auaaccaacc                                                   20


<210>  18120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18120
cccuaccuga ucacacugaa                                                   20


<210>  18121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18121
gugugaucag guagggggaa                                                   20


<210>  18122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18122
ggguuucuua cugacgcccu                                                   20


<210>  18123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18123
uacugacgcc cuugcuuccc                                                   20


<210>  18124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18124
cuauuguagc uuugaaauua                                                   20


<210>  18125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18125
aagcuacaau agggaagcaa                                                   20


<210>  18126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18126
caagcacaau uaaaagucua                                                   20


<210>  18127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18127
uugcagaaca gaaaguuaca                                                   20


<210>  18128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18128
gcaaugaaaa uggccuccug                                                   20


<210>  18129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18129
guucugcaau gaaaauggcc                                                   20


<210>  18130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18130
uucuuuguug gcugggggua                                                   20


<210>  18131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18131
uuguuggcug gggguagggu                                                   20


<210>  18132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18132
uccucccucc uuacccuacc                                                   20


<210>  18133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18133
cuuccuccuc ccuccuuacc                                                   20


<210>  18134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18134
auuucaaugu cucacuucag                                                   20


<210>  18135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18135
augucucacu ucaggucaga                                                   20


<210>  18136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18136
ggucagagau uagaacuucc                                                   20


<210>  18137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18137
aaucucugac cugaagugag                                                   20


<210>  18138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18138
aagcucugug ugaacagggc                                                   20


<210>  18139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18139
cacagagcuu ggaaguucua                                                   20


<210>  18140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18140
cugggcugug auuuccugcu                                                   20


<210>  18141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18141
ugcuccagca ccagcgugcu                                                   20


<210>  18142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18142
gcauugacag aggagaaaaa                                                   20


<210>  18143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18143
ccucugucaa ugcugaagca                                                   20


<210>  18144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18144
cuuucuguug gcacugaucg                                                   20


<210>  18145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18145
guuggcacug aucgggaaau                                                   20


<210>  18146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18146
cgaucagugc caacagaaag                                                   20


<210>  18147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18147
ccacccucca gugccauagu                                                   20


<210>  18148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18148
acuccaugga cuauggcacu                                                   20


<210>  18149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18149
aaauucaaac cuguuccagg                                                   20


<210>  18150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18150
aaccuguucc aggucaaaga                                                   20


<210>  18151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18151
aggucaaaga uucuuauguc                                                   20


<210>  18152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18152
uaugucaagg cagaagaaua                                                   20


<210>  18153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18153
gccuugacau aagaaucuuu                                                   20


<210>  18154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18154
ucugccuuga cauaagaauc                                                   20


<210>  18155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18155
uuuauaaagc uaauugauua                                                   20


<210>  18156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18156
acucuuauuc uacucuucuc                                                   20


<210>  18157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18157
acucuucucu ugauggucgg                                                   20


<210>  18158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18158
cuugaugguc ggcuggcuga                                                   20


<210>  18159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18159
caaaacacac ucuuugcuuc                                                   20


<210>  18160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18160
gucaggaugg caaucccaca                                                   20


<210>  18161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18161
ucaacuacac caccucccgc                                                   20


<210>  18162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18162
acuacaccac cucccgccua                                                   20


<210>  18163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18163
ucuuggcccu uccccaggau                                                   20


<210>  18164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18164
uggcccuucc ccaggauugc                                                   20


<210>  18165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18165
ccaggauugc ucuccaaccc                                                   20


<210>  18166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18166
cuccaucuuu ccauccuucc                                                   20


<210>  18167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18167
auccuuccaa gccucauuca                                                   20


<210>  18168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18168
aagccucauu cagccccagu                                                   20


<210>  18169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18169
gccccaguuc cucucugaag                                                   20


<210>  18170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18170
ucucugaagc ucccccugau                                                   20


<210>  18171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18171
gagaggaacu ggggcugaau                                                   20


<210>  18172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18172
accccucaca gaccucccug                                                   20


<210>  18173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18173
acaaggcaaa gcugguggca                                                   20


<210>  18174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18174
ucaccuggcg acuuguacca                                                   20


<210>  18175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18175
aaagaaugcc uaagagggug                                                   20


<210>  18176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18176
uuggaaugca cagacacaug                                                   20


<210>  18177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18177
uccccaaaca ggcaaguauu                                                   20


<210>  18178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18178
aggcaucuag ccuauggaaa                                                   20


<210>  18179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18179
auaggcuaga ugccuggaag                                                   20


<210>  18180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18180
auguauaaac ucauuuaaac                                                   20


<210>  18181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18181
aaaccuuuuc cauguauaaa                                                   20


<210>  18182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18182
ggauuaaugg uaguuguugc                                                   20


<210>  18183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18183
cuguaauauu guuuauaaua                                                   20


<210>  18184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18184
ggccauuugg guuugcucca                                                   20


<210>  18185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18185
uucuggccau uuggguuugc                                                   20


<210>  18186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18186
aaaacgauac ucuuccuucu                                                   20


<210>  18187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18187
uuuuaaaaug uaccuacaau                                                   20


<210>  18188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18188
guauauauaa auuuaauucu                                                   20


<210>  18189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18189
ccauuucagu auauauaaau                                                   20


<210>  18190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18190
gugguuugcu uuuuugauaa                                                   20


<210>  18191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18191
ucuuuuuaag aacuagguag                                                   20


<210>  18192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18192
uaaaaagaug aaaucauacu                                                   20


<210>  18193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18193
uggcagcagc auaaagucau                                                   20


<210>  18194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18194
cugccuacua ccuacgugag                                                   20


<210>  18195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18195
ggagcucacg uagguaguag                                                   20


<210>  18196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18196
uuaucucuca aauggggaaa                                                   20


<210>  18197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18197
ccauuugaga gauaaggaaa                                                   20


<210>  18198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18198
uauauguaaa gcacuuagaa                                                   20


<210>  18199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18199
aagugcuuua cauauaugaa                                                   20


<210>  18200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18200
ccaguaaagg uuaguucuua                                                   20


<210>  18201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18201
uaccacuguu auuaucugaa                                                   20


<210>  18202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18202
gauaauaaca gugguaagaa                                                   20


<210>  18203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18203
uuuucagaua auaacagugg                                                   20


<210>  18204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18204
gucuuuuuuc cuuuucagau                                                   20


<210>  18205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18205
ucuggagaga caaauuagga                                                   20


<210>  18206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18206
ccuaauuugu cucuccagag                                                   20


<210>  18207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18207
uuuucuccua auuugucucu                                                   20


<210>  18208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18208
gguuugguuu uguuuuacca                                                   20


<210>  18209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18209
uaaggacaaa cugcuaccug                                                   20


<210>  18210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18210
ccauuucuaa auccugauuc                                                   20


<210>  18211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18211
aaauccugau ucuaauucca                                                   20


<210>  18212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18212
aauuccaauc cacagccaga                                                   20


<210>  18213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18213
aauccacagc cagaaaauua                                                   20


<210>  18214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18214
ggcuguggau uggaauuaga                                                   20


<210>  18215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18215
gcauguugug ggguugcaga                                                   20


<210>  18216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18216
ccauuuuuca gcauguugug                                                   20


<210>  18217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18217
uuuuuuaaaa cagauguucu                                                   20


<210>  18218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18218
cguuuaaaau aguaauugau                                                   20


<210>  18219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18219
ucccguuuaa aauaguaauu                                                   20


<210>  18220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18220
cuuucuuccc guuuaaaaua                                                   20


<210>  18221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18221
uguucccuuu cuucccguuu                                                   20


<210>  18222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18222
ugcaucuuga cagccaaggu                                                   20


<210>  18223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18223
uguaguagaa gaugguucaa                                                   20


<210>  18224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18224
acuacaggaa gaugauuauu                                                   20


<210>  18225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18225
aaauaccaua acuuuccuac                                                   20


<210>  18226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18226
uacuacuccc uuucaccugg                                                   20


<210>  18227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18227
ccuggcaaaa uccucgucuu                                                   20


<210>  18228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18228
aagacaccuu cccagacaac                                                   20


<210>  18229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18229
cagacaacuc cagucugcag                                                   20


<210>  18230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18230
cucccuacuc ccaacucaga                                                   20


<210>  18231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18231
cugcccuccc gcaucugggu                                                   20


<210>  18232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18232
ggugacucau gucaugauuu                                                   20


<210>  18233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18233
ccacacucug gggccuuggg                                                   20


<210>  18234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18234
guguccucca ccacaucuca                                                   20


<210>  18235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18235
ggggaugcag ucagacuggc                                                   20


<210>  18236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18236
uuuuugagau ggagucuuac                                                   20


<210>  18237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18237
ccugccucag ccucccaagu                                                   20


<210>  18238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18238
ccauguuggc caggaugauc                                                   20


<210>  18239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18239
auugcucacu uuuguggcca                                                   20


<210>  18240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18240
ccuuauauuu gccaucucua                                                   20


<210>  18241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18241
cauacccacc ucucgcuauu                                                   20


<210>  18242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18242
uucaggccaa cuuauuauaa                                                   20


<210>  18243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18243
ggccaacuua uuauaauacc                                                   20


<210>  18244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18244
cccacucccc ucugcacccc                                                   20


<210>  18245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18245
gcuaggcaca ggaugagggg                                                   20


<210>  18246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18246
gaggguggcu ugugugauuu                                                   20


<210>  18247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18247
acuggaucgc aaauuccugg                                                   20


<210>  18248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18248
uggaaggcag gauacguguc                                                   20


<210>  18249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18249
aggaauuugc gauccaguug                                                   20


<210>  18250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18250
uuuccuuucu cagauugggc                                                   20


<210>  18251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18251
uuucucagau ugggcaugag                                                   20


<210>  18252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18252
cagauugggc augaguggag                                                   20


<210>  18253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18253
cucaacucca agccuuugcu                                                   20


<210>  18254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18254
cacuccgccu ucccucaacu                                                   20


<210>  18255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18255
uuuaguaguu auaucuaucu                                                   20


<210>  18256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18256
uauuugucuu uucauucauu                                                   20


<210>  18257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18257
uucauuuuuc uugcugggaa                                                   20


<210>  18258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18258
uuuuucuugc ugggaaagaa                                                   20


<210>  18259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18259
ugcugggaaa gaaaaaaaaa                                                   20


<210>  18260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18260
cagcaagaaa aaugaaugaa                                                   20


<210>  18261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18261
uucccagcaa gaaaaaugaa                                                   20


<210>  18262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18262
gcucugauaa gaugaauuuu                                                   20


<210>  18263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18263
ucuuaucaga gcugaaaguu                                                   20


<210>  18264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18264
caaaagccaa uaauuccaca                                                   20


<210>  18265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18265
acauggcuca ucuaaaauua                                                   20


<210>  18266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18266
cucuaauuuu agaugagcca                                                   20


<210>  18267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18267
uagggaauug gagcagcagg                                                   20


<210>  18268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18268
cuaagaaagu cauuuaaaua                                                   20


<210>  18269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18269
ggcaucugau acauugccug                                                   20


<210>  18270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18270
cuuaguguaa uauuuaaaug                                                   20


<210>  18271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18271
cuucccuuag uguaauauuu                                                   20


<210>  18272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18272
uuuuagcagc uugaccaaac                                                   20


<210>  18273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18273
gucccugccu auucauuuua                                                   20


<210>  18274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18274
ccagggcauu ucugucccug                                                   20


<210>  18275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18275
ucuugaaucu auuugaaaga                                                   20


<210>  18276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18276
agaugaaaua cccagcacuu                                                   20


<210>  18277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18277
aauagauuca agaugaaaua                                                   20


<210>  18278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18278
acuauuuucu ggaaucggua                                                   20


<210>  18279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18279
ggaaucggua uuuguacaaa                                                   20


<210>  18280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18280
agaaaauagu ugaaguacua                                                   20


<210>  18281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18281
aguuggccag cucggccugg                                                   20


<210>  18282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18282
uuguuuagaa acacaaaaca                                                   20


<210>  18283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18283
aaacaaggaa auugaggagu                                                   20


<210>  18284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18284
auaggacuuu guuuuguguu                                                   20


<210>  18285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18285
gucuacaacu ggaaacugcu                                                   20


<210>  18286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18286
aguuguagac ugaaauauug                                                   20


<210>  18287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18287
ucugcaggaa aaacauguau                                                   20


<210>  18288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18288
gcaggaaaaa cauguauucc                                                   20


<210>  18289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18289
ugcagaagaa aaaaguuagc                                                   20


<210>  18290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18290
cacugacacc uacugcuguc                                                   20


<210>  18291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18291
aacauuuuac aggaaauaca                                                   20


<210>  18292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18292
uguaaaaugu uugaaaucuc                                                   20


<210>  18293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18293
aguaggaucc caggaaaagg                                                   20


<210>  18294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18294
ugggauccua cuggaaaagc                                                   20


<210>  18295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18295
guuuugccac caccugcaca                                                   20


<210>  18296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18296
ugcagggguc cuccggguaa                                                   20


<210>  18297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18297
uauggccagc agaggcagga                                                   20


<210>  18298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18298
ugccucugcu ggccauagga                                                   20


<210>  18299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18299
agcacaguug ggauguugug                                                   20


<210>  18300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18300
ccauaguucu caaagguuau                                                   20


<210>  18301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18301
caaagguuau agaacccccu                                                   20


<210>  18302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18302
auaaccuuug agaacuaugg                                                   20


<210>  18303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18303
ucccuuguaa acucuuucag                                                   20


<210>  18304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18304
cuuguaaacu cuuucagcaa                                                   20


<210>  18305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18305
gcaauagucu ucccugcucc                                                   20


<210>  18306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18306
cugcuccccc uauauuguca                                                   20


<210>  18307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18307
gcuaugaugu guugacaaua                                                   20


<210>  18308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18308
acugaggcuu cagcuaugau                                                   20


<210>  18309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18309
cauaaaaugg gacaugaaaa                                                   20


<210>  18310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18310
ugucccauuu uaugggaaau                                                   20


<210>  18311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18311
ugcacagacc cagcaggggc                                                   20


<210>  18312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18312
ugucgccccu gcugggucug                                                   20


<210>  18313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18313
uuaaugucuu uccugucgcc                                                   20


<210>  18314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18314
aaagcaaugg gcuacauuuu                                                   20


<210>  18315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18315
ggcuaaaaug uagcccauug                                                   20


<210>  18316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18316
uuuuaggguc agugagagua                                                   20


<210>  18317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18317
gauggcuaaa aucccauaua                                                   20


<210>  18318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18318
uugaaaacgc ucuucaacau                                                   20


<210>  18319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18319
aagaauuaua ugggauuuua                                                   20


<210>  18320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18320
acauucccau uuuaauuucc                                                   20


<210>  18321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18321
cauuuuaauu uccaaaauca                                                   20


<210>  18322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18322
aaaaucaaua uggcuugcua                                                   20


<210>  18323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18323
uauugauggg gaggaaggga                                                   20


<210>  18324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18324
uccccaucaa uaugaauugu                                                   20


<210>  18325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18325
ucccuuccuc cccaucaaua                                                   20


<210>  18326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18326
auugaaugga aaauuugguu                                                   20


<210>  18327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18327
auagaaaaau guucaucccu                                                   20


<210>  18328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18328
auucaauaga aaaauguuca                                                   20


<210>  18329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18329
aagagagaaa aaggucuuaa                                                   20


<210>  18330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18330
cucuuggaau aauguccuua                                                   20


<210>  18331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18331
uuuguuccua gaaggcuggu                                                   20


<210>  18332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18332
uagaaggcug guuucucuug                                                   20


<210>  18333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18333
aggaacaaaa gaauacucug                                                   20


<210>  18334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18334
cuugacaucu cugcccucau                                                   20


<210>  18335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18335
gucaugcagu uucaagcccc                                                   20


<210>  18336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18336
agccccaaaa cagaauguug                                                   20


<210>  18337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18337
guuuuggggc uugaaacugc                                                   20


<210>  18338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18338
ucugaagaaa uggcacccug                                                   20


<210>  18339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18339
gaagaaaugg cacccugcuc                                                   20


<210>  18340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18340
gaagaaaaau aaaugacaac                                                   20


<210>  18341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18341
ucagaagaaa aauaaaugac                                                   20


<210>  18342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18342
acguauauuc acuaacuagg                                                   20


<210>  18343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18343
cuaacuaggu aauaaucacu                                                   20


<210>  18344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18344
ugugcuaaug gcaagugauu                                                   20


<210>  18345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18345
gcagcaccac uuacgcacaa                                                   20


<210>  18346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18346
agcucuucag cagcaccacu                                                   20


<210>  18347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18347
cagguaggua aauggucccu                                                   20


<210>  18348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18348
cacuguuaau uugcugagca                                                   20


<210>  18349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18349
ucaaggacug ugcaaacacc                                                   20


<210>  18350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18350
ggcuccaugu uaaggaagcu                                                   20


<210>  18351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18351
gucaucccua cuaaaggcau                                                   20


<210>  18352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18352
cugucagaca aauaaucugu                                                   20


<210>  18353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18353
cuuguugcuu uucuucucaa                                                   20


<210>  18354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18354
uucccuuguu gcuuuucuuc                                                   20


<210>  18355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18355
gaaucuugga aggagaagug                                                   20


<210>  18356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18356
gaauuguacu uucauucccu                                                   20


<210>  18357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18357
aagauucaga auuguacuuu                                                   20


<210>  18358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18358
ccuuccaaga uucagaauug                                                   20


<210>  18359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18359
cuucuccuuc caagauucag                                                   20


<210>  18360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18360
uuucacuucu ccuuccaaga                                                   20


<210>  18361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18361
ccuacuuuga uaagcauucu                                                   20


<210>  18362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18362
gucuuccccu acuuugauaa                                                   20


<210>  18363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18363
uuucugucuu ccccuacuuu                                                   20


<210>  18364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18364
ucuuuucugu cuuccccuac                                                   20


<210>  18365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18365
cauagucauu uuccauaacu                                                   20


<210>  18366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18366
auaacugcug agucacugcu                                                   20


<210>  18367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18367
agcagugacu cagcaguuau                                                   20


<210>  18368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18368
ugacaagcca acauaauacu                                                   20


<210>  18369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18369
aucaaacugu guucauuugg                                                   20


<210>  18370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18370
uuuggcaaaa aguuuucucu                                                   20


<210>  18371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18371
cuccuaggga ccaucagaac                                                   20


<210>  18372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18372
gauggucccu aggagagaaa                                                   20


<210>  18373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18373
uaagccaagu ucugaugguc                                                   20


<210>  18374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18374
caagguguuu ggagagccug                                                   20


<210>  18375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18375
ugcacauaag ugcaacuccu                                                   20


<210>  18376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18376
gaugaaguca augaaggugu                                                   20


<210>  18377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18377
ucagaauuua gauguauuaa                                                   20


<210>  18378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18378
uugacuucau cagaauuuag                                                   20


<210>  18379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18379
aguucacaug gagauguuaa                                                   20


<210>  18380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18380
cauggagaug uuaacuccac                                                   20


<210>  18381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18381
cuuugauaag uggaguuaac                                                   20


<210>  18382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18382
uaauugagug ccuuuuugua                                                   20


<210>  18383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18383
acuuuucaua auugagugcc                                                   20


<210>  18384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18384
uuuugguuuc uacuuuucau                                                   20


<210>  18385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18385
ugaauuuauu accuuagaaa                                                   20


<210>  18386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18386
ggaaacccca gcugaggcca                                                   20


<210>  18387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18387
aagguaauaa auucaggaaa                                                   20


<210>  18388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18388
acccaauaug guaguuggug                                                   20


<210>  18389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18389
uaucucuaag ucuuucccuc                                                   20


<210>  18390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18390
uucauaucuc uaagucuuuc                                                   20


<210>  18391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18391
ccuuucuuuc auaucucuaa                                                   20


<210>  18392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18392
cuacuccucc ucccuggccu                                                   20


<210>  18393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18393
accguucccu acuccuccuc                                                   20


<210>  18394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18394
uucuaccguu cccuacuccu                                                   20


<210>  18395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18395
acuugaauug ugguucaguc                                                   20


<210>  18396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18396
aguggaaggu ccaucuucug                                                   20


<210>  18397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18397
guccaccuuc uugaaacaaa                                                   20


<210>  18398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18398
ugaaacaaaa caguaaugau                                                   20


<210>  18399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18399
agaaggugga cugaaccaca                                                   20


<210>  18400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18400
auggccacau cuucugucau                                                   20


<210>  18401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18401
cuauuucaug ccaaaguuag                                                   20


<210>  18402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18402
ugccaaaguu aggcauugaa                                                   20


<210>  18403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18403
ucuccagcgu ccugguaaag                                                   20


<210>  18404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18404
ccagcguccu gguaaaggag                                                   20


<210>  18405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18405
ccagggucug ucuaccuuuu                                                   20


<210>  18406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18406
cagcucuuua caccucuucu                                                   20


<210>  18407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18407
auuagucagg acuagaggau                                                   20


<210>  18408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18408
gguggugucc uuacacuuua                                                   20


<210>  18409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18409
uguuucuggu gguguccuua                                                   20


<210>  18410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18410
ucccacucuu guucuuaguc                                                   20


<210>  18411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18411
gcauccacgc acaugagugu                                                   20


<210>  18412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18412
agggacugca ggccauuuuu                                                   20


<210>  18413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18413
uuaaucuuga uguuacuuua                                                   20


<210>  18414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18414
ggcccaacga ucuccuagua                                                   20


<210>  18415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18415
aaugccacug cauuuucuca                                                   20


<210>  18416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18416
caauaccacu ugaccucuua                                                   20


<210>  18417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18417
caauuucuuu uuuuacaaug                                                   20


<210>  18418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18418
uuuuuuacaa ugggaaguga                                                   20


<210>  18419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18419
cauuguaaaa aaagaaauug                                                   20


<210>  18420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18420
cuuaugacua gccugaugga                                                   20


<210>  18421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18421
uucuggacau ugaaaaaaua                                                   20


<210>  18422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18422
ggacauugaa aaaauaccca                                                   20


<210>  18423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18423
auguccagaa agaagcugcc                                                   20


<210>  18424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18424
ugccugauag cuaccacccc                                                   20


<210>  18425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18425
gggcuugguu uuggcacuga                                                   20


<210>  18426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18426
ggaucaaugg aaaaggcaga                                                   20


<210>  18427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18427
auugauccug aaggccaugc                                                   20


<210>  18428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18428
gccuuuucca uugauccuga                                                   20


<210>  18429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18429
ggaaauuccg ggccgucugc                                                   20


<210>  18430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18430
ugaaggcaag ccaggcccuc                                                   20


<210>  18431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18431
gggccgucug cagcagcugu                                                   20


<210>  18432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18432
aguaguacaa caaauucacu                                                   20


<210>  18433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18433
cuuacugaau gacaacagcu                                                   20


<210>  18434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18434
guaagugaau uuguuguacu                                                   20


<210>  18435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18435
auuaaagccc cugcauccaa                                                   20


<210>  18436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18436
uuaugcagag agggcugccg                                                   20


<210>  18437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18437
auguucuuua ugcagagagg                                                   20


<210>  18438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18438
cugagugccc ucagcccuag                                                   20


<210>  18439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18439
ucccucuccc ucucauguag                                                   20


<210>  18440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18440
uucaucccuc ucccucucau                                                   20


<210>  18441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18441
acggcugagc cuccaaaaug                                                   20


<210>  18442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18442
agccuguccu ggucaguuug                                                   20


<210>  18443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18443
ugccccaggu gcccacguca                                                   20


<210>  18444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18444
cccucccuuc uugccccagg                                                   20


<210>  18445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18445
ccaucuccug cuucccccuc                                                   20


<210>  18446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18446
ccucuaaacc uccuucgcca                                                   20


<210>  18447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18447
cuacuucccc ucuaaaccuc                                                   20


<210>  18448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18448
uuuuucguuu uuacaaaaua                                                   20


<210>  18449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18449
uuuuuacaaa auauguccuu                                                   20


<210>  18450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18450
gaguucugac augagcuuau                                                   20


<210>  18451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18451
gacaugagcu uauuaggggg                                                   20


<210>  18452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18452
gcccccuaau aagcucaugu                                                   20


<210>  18453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18453
acaggcagcc cucccuuucc                                                   20


<210>  18454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18454
aguucuacag gcagcccucc                                                   20


<210>  18455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18455
cauaaaauau acauagcaga                                                   20


<210>  18456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18456
ccuucaguaa caaagauaaa                                                   20


<210>  18457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18457
guaacaaaga uaaaaucagg                                                   20


<210>  18458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18458
cuuuggugcc ccuccuccau                                                   20


<210>  18459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18459
augaaggugg gcagcccuca                                                   20


<210>  18460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18460
uggaaaugag ccagcuggag                                                   20


<210>  18461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18461
ugauaguaac agguuaccau                                                   20


<210>  18462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18462
ccaacaauuc aagucgggug                                                   20


<210>  18463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18463
agucggguga aaagcuaggc                                                   20


<210>  18464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18464
cccgacuuga auuguuggag                                                   20


<210>  18465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18465
gaauggaauu ucuggaauuu                                                   20


<210>  18466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18466
ggaggaucgc caugagcaga                                                   20


<210>  18467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18467
aggcaaacau ucuggaggau                                                   20


<210>  18468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18468
auucuaggca aacauucugg                                                   20


<210>  18469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18469
gaauuaacaa uucagagcaa                                                   20


<210>  18470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18470
gaaguucgau ucuaggcaaa                                                   20


<210>  18471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18471
gagcaaaugc caacuccacc                                                   20


<210>  18472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18472
ugguggaguu ggcauuugcu                                                   20


<210>  18473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18473
cagauucucu caauaggaau                                                   20


<210>  18474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18474
cucaauagga auaaauuacu                                                   20


<210>  18475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18475
cuaauagaua agaggcuucc                                                   20


<210>  18476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18476
uggagccggg gugugggcuu                                                   20


<210>  18477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18477
auagagcuag ugcucaauaa                                                   20


<210>  18478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18478
gcuuagauuu auugagcacu                                                   20


<210>  18479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18479
auucugcuua gauuuauuga                                                   20


<210>  18480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18480
guucaauucu gcuuagauuu                                                   20


<210>  18481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18481
uaagggccau ucaguucaau                                                   20


<210>  18482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18482
auuuccuaag ggccauucag                                                   20


<210>  18483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18483
aagacuaagg cauugccaaa                                                   20


<210>  18484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18484
cugccgcuuu cuucauugca                                                   20


<210>  18485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18485
ucauugcagc caccaaauua                                                   20


<210>  18486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18486
uugcagccac caaauuaguu                                                   20


<210>  18487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18487
aauuaaagug ggcaacuaau                                                   20


<210>  18488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18488
aguagggcug gccagacauc                                                   20


<210>  18489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18489
gguucuagua gggcuggcca                                                   20


<210>  18490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18490
cagcuggggg cccaaguggc                                                   20


<210>  18491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18491
ugugguuggg ucaccuuccc                                                   20


<210>  18492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18492
cuugcauacu uccuucccuc                                                   20


<210>  18493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18493
uucccucuug acuccuuucu                                                   20


<210>  18494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18494
cucuugacuc cuuucucccc                                                   20


<210>  18495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18495
cccccacccc cauccugagg                                                   20


<210>  18496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18496
ugacaacaca ucuguccagc                                                   20


<210>  18497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18497
cacuguccca ugauucggcu                                                   20


<210>  18498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18498
gcuacccaag gcauuugcau                                                   20


<210>  18499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18499
ugcccuugca gugaucaaag                                                   20


<210>  18500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18500
gaagccuacc auccacuaag                                                   20


<210>  18501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18501
gaaaggggau acccugucuc                                                   20


<210>  18502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18502
uuacuuagug gaugguaggc                                                   20


<210>  18503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18503
uuaaucaaug uuucauggaa                                                   20


<210>  18504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18504
uggaagggau aaauccuuua                                                   20


<210>  18505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18505
augaaacauu gauuaaugaa                                                   20


<210>  18506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18506
ugauuuuucc cccauuuaaa                                                   20


<210>  18507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18507
cccauuuaaa aaaugcagug                                                   20


<210>  18508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18508
ucccugcuau uagcucacau                                                   20


<210>  18509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18509
cugcuauuag cucacauaga                                                   20


<210>  18510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18510
cagccuccca aaacucaccc                                                   20


<210>  18511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18511
cucugagguc augaaguuca                                                   20


<210>  18512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18512
ugaccucaga gugaauguga                                                   20


<210>  18513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18513
auggagaaaa caaaggggua                                                   20


<210>  18514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18514
ccauugaacu ucaugaccuc                                                   20


<210>  18515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18515
accccuuugu uuucuccauu                                                   20


<210>  18516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18516
gucccucauu cuaccccuuu                                                   20


<210>  18517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18517
aguuagucuu aagcauguuu                                                   20


<210>  18518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18518
uuaaauaaaa ccuucauaaa                                                   20


<210>  18519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18519
uaaacccuaa aaaagaaugu                                                   20


<210>  18520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18520
uuuuuagggu uuaugaaggu                                                   20


<210>  18521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18521
uuuguacacu cacuaagugc                                                   20


<210>  18522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18522
uuaaugucag uaauauagca                                                   20


<210>  18523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18523
ugucuucuuu aaugucagua                                                   20


<210>  18524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18524
ugcuuguaau cccagcacuu                                                   20


<210>  18525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18525
ucaagaugga gucuugcucu                                                   20


<210>  18526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18526
ugucuuuuuu uguuuuuguu                                                   20


<210>  18527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18527
uauuaccacc acaaaaaccc                                                   20


<210>  18528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18528
ccuaaggugu ggguuuuugu                                                   20


<210>  18529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18529
gguaaauagg auaucacaga                                                   20


<210>  18530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18530
uggaggaugu ugaccaaaga                                                   20


<210>  18531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18531
guccuuugca acauacuuac                                                   20


<210>  18532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18532
gaggucuugu ggugguguua                                                   20


<210>  18533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18533
ccucaacuua uggaauagug                                                   20


<210>  18534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18534
auaaguugag gagaacaugu                                                   20


<210>  18535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18535
cuauuccaua aguugaggag                                                   20


<210>  18536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18536
cacuguaauu guucuauaaa                                                   20


<210>  18537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18537
auaaagcccc uuuuccccau                                                   20


<210>  18538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18538
ccauuaguuu caaaugcaau                                                   20


<210>  18539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18539
aaugcaaugu cuacuguuga                                                   20


<210>  18540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18540
ugaaugacac uuuuuaaaaa                                                   20


<210>  18541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18541
ggaaccagga uauuugcuca                                                   20


<210>  18542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18542
auauuuguau uauuuguugc                                                   20


<210>  18543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18543
cacuguuaua agucauauug                                                   20


<210>  18544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18544
guuucccacu guuauaaguc                                                   20


<210>  18545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18545
uguagccauu aggaggacaa                                                   20


<210>  18546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18546
auguuacugu guagucuuug                                                   20


<210>  18547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18547
cacuuagcau gugucauuuu                                                   20


<210>  18548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18548
uuucccacuu agcauguguc                                                   20


<210>  18549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18549
aguuucuuuu cccacuuagc                                                   20


<210>  18550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18550
agccuuuuua aaaaauaagu                                                   20


<210>  18551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18551
uuccagccuu uuuaaaaaau                                                   20


<210>  18552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18552
cgaaauaucc auaaugcucu                                                   20


<210>  18553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18553
agaaguaaag auaagggaua                                                   20


<210>  18554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18554
uuugcaucau aaagacagag                                                   20


<210>  18555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18555
auuucuuuug caucauaaag                                                   20


<210>  18556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18556
uuaaagaguu gcuagguuuc                                                   20


<210>  18557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18557
aaauuaugcc uacuuaaaaa                                                   20


<210>  18558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18558
uuauuucaaa auuaugccua                                                   20


<210>  18559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18559
aacuauagua aacccaaauu                                                   20


<210>  18560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18560
uguggagaca gcuacccugg                                                   20


<210>  18561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18561
auugacacag aguuauaggc                                                   20


<210>  18562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18562
agauauuuuc auuucaccug                                                   20


<210>  18563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18563
uuucaccuga acaguuuauu                                                   20


<210>  18564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18564
ccugaacagu uuauuucagu                                                   20


<210>  18565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18565
ggugaaauga aaauaucuag                                                   20


<210>  18566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18566
guaucacugg augggagaaa                                                   20


<210>  18567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18567
aggguccacc caugaacagc                                                   20


<210>  18568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18568
uggcuccgua ucucucuccc                                                   20


<210>  18569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18569
uccuggcucc guaucucucu                                                   20


<210>  18570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18570
aaacugguag gcucauucuu                                                   20


<210>  18571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18571
aagaucauac acagcggauc                                                   20


<210>  18572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18572
uaacucuuca aagaucauac                                                   20


<210>  18573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18573
ucuuaacucu ucaaagauca                                                   20


<210>  18574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18574
cauucuucuu aacucuucaa                                                   20


<210>  18575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18575
guucucauuc uucuuaacuc                                                   20


<210>  18576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18576
aguggaucau gcauacuucu                                                   20


<210>  18577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18577
uggccagaau ccauucccaa                                                   20


<210>  18578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18578
ggccaagaag uaugcaugau                                                   20


<210>  18579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18579
caaaugagca ccucugcguc                                                   20


<210>  18580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18580
gugagacgca gaggugcuca                                                   20


<210>  18581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18581
uggcagcugg aaauaauuua                                                   20


<210>  18582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18582
agcugccaug aacuaaauuu                                                   20


<210>  18583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18583
acucaccgaa gacuauagaa                                                   20


<210>  18584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18584
cacauaagcu auaaaugcua                                                   20


<210>  18585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18585
uaggaggaga ccauugucuu                                                   20


<210>  18586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18586
aauucaaauu cauaagcaua                                                   20


<210>  18587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18587
aauucauaag cauaaacuau                                                   20


<210>  18588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18588
uaagcauaaa cuaucuaaca                                                   20


<210>  18589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18589
gcuuggaagc cagaccuuau                                                   20


<210>  18590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18590
aagcugaaua ugauauuguc                                                   20


<210>  18591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18591
cacuuuauaa ggucuggcuu                                                   20


<210>  18592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18592
gcgcacuccu augguguguu                                                   20


<210>  18593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18593
ucaucucagu guuuuugguc                                                   20


<210>  18594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18594
gccauguucu ucccagggaa                                                   20


<210>  18595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18595
ucccagggaa acgauaggaa                                                   20


<210>  18596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18596
cagggaaacg auaggaagaa                                                   20


<210>  18597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18597
cugggaagaa cauggcugaa                                                   20


<210>  18598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18598
uaucguuucc cugggaagaa                                                   20


<210>  18599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18599
uccuaucguu ucccugggaa                                                   20


<210>  18600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18600
cccaggugaa aguccucguc                                                   20


<210>  18601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18601
ccugggagaa gagcucauuc                                                   20


<210>  18602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18602
uggcaugagc agaguuuagg                                                   20


<210>  18603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18603
uaaacucugc ucaugccaag                                                   20


<210>  18604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18604
uuucugaaac aggcacacag                                                   20


<210>  18605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18605
gaaacaggca cacaggugcc                                                   20


<210>  18606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18606
gaaaugaaag uaacuuccua                                                   20


<210>  18607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18607
cccuuggacu cucagguuuu                                                   20


<210>  18608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18608
ggcagacuug caaaaaccug                                                   20


<210>  18609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18609
uugacucugg gugggcugag                                                   20


<210>  18610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18610
gcaauaaccc ucuuccuuga                                                   20


<210>  18611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18611
aacuuaaugc cuccuuucug                                                   20


<210>  18612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18612
caaagugcug ugcuugggcc                                                   20


<210>  18613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18613
auauccucug agggucaacg                                                   20


<210>  18614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18614
uugaaaauua aaaccuucca                                                   20


<210>  18615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18615
aagaacaucc uaugaucuca                                                   20


<210>  18616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18616
agaaguguca guucuugucu                                                   20


<210>  18617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18617
ggaagguuuu aauuuucaaa                                                   20


<210>  18618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18618
ugucuaguau gcacagacuc                                                   20


<210>  18619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18619
aggaagccua uagccauucu                                                   20


<210>  18620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18620
uagaaaauau gagcuaggau                                                   20


<210>  18621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18621
acacaguguu aaugcggacc                                                   20


<210>  18622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18622
ggucugcuua gcacaggucc                                                   20


<210>  18623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18623
uuguuucugg ucugcuuagc                                                   20


<210>  18624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18624
ggacacguuc agacuuggac                                                   20


<210>  18625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18625
gcaucaugug uuuagauggc                                                   20


<210>  18626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18626
ugugccuccu caccagcccu                                                   20


<210>  18627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18627
acgcaggauu ccaaauaauc                                                   20


<210>  18628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18628
aaauaaucaa uuuucugccu                                                   20


<210>  18629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18629
gccuguaguu gcauguuuag                                                   20


<210>  18630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18630
aaacaugcaa cuacaggcag                                                   20


<210>  18631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18631
cauucuaaac augcaacuac                                                   20


<210>  18632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18632
gaccuuugcu uuuuauucca                                                   20


<210>  18633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18633
agauggaauc uguuuauaga                                                   20


<210>  18634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18634
aucuggaaua aaaagcaaag                                                   20


<210>  18635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18635
auaaacagau uccaucugga                                                   20


<210>  18636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18636
ggggccacgg agggguggag                                                   20


<210>  18637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18637
uccaccccuc cguggccccu                                                   20


<210>  18638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18638
gggaaggcuu uggggcccca                                                   20


<210>  18639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18639
cagaagcccc cucugccaac                                                   20


<210>  18640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18640
ucuucaaaua gagcagcugc                                                   20


<210>  18641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18641
aauagagcag cugcacuucu                                                   20


<210>  18642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18642
accuaauugg gcuuccacag                                                   20


<210>  18643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18643
acagaaggcc ucauuuugcu                                                   20


<210>  18644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18644
guggaagccc aauuagguag                                                   20


<210>  18645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18645
ggcaaccccu gggaggggcu                                                   20


<210>  18646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18646
ccugcccugu cccccaccua                                                   20


<210>  18647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18647
uuugagaacu guccuuugaa                                                   20


<210>  18648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18648
gaggcauuaa uauguuucuu                                                   20


<210>  18649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18649
uggugccacu ucagaggcau                                                   20


<210>  18650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18650
gggaggacag ccuuggagac                                                   20


<210>  18651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18651
gcuuacaccu ucugggagga                                                   20


<210>  18652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18652
ggacaauguc caaacccaua                                                   20


<210>  18653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18653
gcuauggguu uggacauugu                                                   20


<210>  18654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18654
cuccugucua ugcacacaca                                                   20


<210>  18655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18655
aacuuuuccu uagguuugaa                                                   20


<210>  18656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18656
uuagguuuga aauuucucug                                                   20


<210>  18657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18657
aaccuaagga aaaguuggaa                                                   20


<210>  18658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18658
cugaauaaau acuggagggg                                                   20


<210>  18659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18659
gagaaauuuc aaaccuaagg                                                   20


<210>  18660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18660
ccuaccccuc caguauuuau                                                   20


<210>  18661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18661
caucaaggua cauuugcccc                                                   20


<210>  18662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18662
uaauuauuaa uaacaaaaaa                                                   20


<210>  18663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18663
ucaaucaugu uagggaaaga                                                   20


<210>  18664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18664
cuaacaugau ugaugaaaau                                                   20


<210>  18665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18665
agauuuuguc auguuugugg                                                   20


<210>  18666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18666
uccucuauaa gaauucacuu                                                   20


<210>  18667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18667
uauagaggag gaaauaaaua                                                   20


<210>  18668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18668
cuuucauagc cuccuucacc                                                   20


<210>  18669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18669
uagccuccuu cacccaaaug                                                   20


<210>  18670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18670
cccaaaugug uaugcauuac                                                   20


<210>  18671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18671
aaaaaacccu aagcacaaaa                                                   20


<210>  18672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18672
uauccaccca ugguaacgug                                                   20


<210>  18673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18673
uggaggucaa augcuaaagu                                                   20


<210>  18674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18674
aauaaacauc uuccuggagg                                                   20


<210>  18675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18675
gcuuuauaca gccacauuca                                                   20


<210>  18676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18676
uuaacccaau ugagucuuga                                                   20


<210>  18677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18677
agacucaauu ggguuaauga                                                   20


<210>  18678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18678
guguuccacg ugaguaaacu                                                   20


<210>  18679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18679
acgugaguaa acugaggcac                                                   20


<210>  18680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18680
cagaaugagg uauaggaucu                                                   20


<210>  18681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18681
gagaaaaguu acucuccacc                                                   20


<210>  18682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18682
uuuggggcaa agacaagcug                                                   20


<210>  18683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18683
aaaaccaaag agguagcucu                                                   20


<210>  18684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18684
ugcugaauuc cacauagaag                                                   20


<210>  18685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18685
uccugcugaa uuccacauag                                                   20


<210>  18686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18686
cuucuuccug cugaauucca                                                   20


<210>  18687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18687
uauuuacuau aacaaaauag                                                   20


<210>  18688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18688
ucuaacacug ggauaggaag                                                   20


<210>  18689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18689
uaucccagug uuagaggaag                                                   20


<210>  18690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18690
aauaagcgag uagccgaagc                                                   20


<210>  18691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18691
gcuacucgcu uauuggaaug                                                   20


<210>  18692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18692
uaccccauuu acuccucauu                                                   20


<210>  18693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18693
uuccuacccc auuuacuccu                                                   20


<210>  18694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18694
cuuaacaagu uuccuuccua                                                   20


<210>  18695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18695
gauccaggag cugugucaac                                                   20


<210>  18696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18696
uagaauguug cacuaugcca                                                   20


<210>  18697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18697
aggaaguugu ggggacauuu                                                   20


<210>  18698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18698
gaggcuggcg uugcccagga                                                   20


<210>  18699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18699
uauugucuua uuggcgauug                                                   20


<210>  18700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18700
uuucccuccu cuuuggccca                                                   20


<210>  18701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18701
cuccucuuug gcccagguug                                                   20


<210>  18702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18702
acuggacaaa uucuaccugu                                                   20


<210>  18703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18703
accugugugu uuggaaagaa                                                   20


<210>  18704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18704
aaacacacag guagaauuug                                                   20


<210>  18705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18705
uuccaaacac acagguagaa                                                   20


<210>  18706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18706
uuucuuuaua aacaauaaua                                                   20


<210>  18707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18707
uuauaaacaa uaauagagca                                                   20


<210>  18708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18708
auugcucuau uauuguuuau                                                   20


<210>  18709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18709
uggaaaccuc auuguugcau                                                   20


<210>  18710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18710
aagaaagcuu uccauugcuc                                                   20


<210>  18711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18711
agaauaugag agauuucaau                                                   20


<210>  18712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18712
agaauggaug gacaagguca                                                   20


<210>  18713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18713
auuguaaugg ugcaacuagc                                                   20


<210>  18714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18714
gugcuaguug caccauuaca                                                   20


<210>  18715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18715
ugguccgggu cagugcucug                                                   20


<210>  18716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18716
uuauaguucc ugguccgggu                                                   20


<210>  18717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18717
caugauuaag ucacuucauc                                                   20


<210>  18718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18718
uccuuacaau uaccccaguu                                                   20


<210>  18719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18719
caauuuauag augagaaaac                                                   20


<210>  18720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18720
uggauugggc agcucugguu                                                   20


<210>  18721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18721
aucacugauu aauuuuguga                                                   20


<210>  18722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18722
guguuccauc acugauuaau                                                   20


<210>  18723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18723
auucuguguu ccaucacuga                                                   20


<210>  18724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18724
gccaagcaga cagaaaacuc                                                   20


<210>  18725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18725
gucugcuugg cugaacugua                                                   20


<210>  18726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18726
gucugaguuu ucugucugcu                                                   20


<210>  18727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18727
aacccuugcc caggaugaaa                                                   20


<210>  18728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18728
aggagcaaug acaggaguca                                                   20


<210>  18729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18729
aaaacaaaac aauaauggac                                                   20


<210>  18730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18730
aaaacauucc aaaugcauca                                                   20


<210>  18731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18731
aaaugcauca ucucauuuag                                                   20


<210>  18732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18732
ucuaacagcc cugugaagaa                                                   20


<210>  18733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18733
aacagcccug ugaagaaagu                                                   20


<210>  18734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18734
acuguuuucu gguucaagau                                                   20


<210>  18735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18735
gguucaagau ccagcgguug                                                   20


<210>  18736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18736
agauccagcg guugaagguc                                                   20


<210>  18737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18737
accgcuggau cuugaaccag                                                   20


<210>  18738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18738
aagagaaggc uggggaaauc                                                   20


<210>  18739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18739
cuuugaacuu gaccuucaac                                                   20


<210>  18740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18740
ccagccuucu cuuugaacuu                                                   20


<210>  18741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18741
aauauauuau uaccaaaugc                                                   20


<210>  18742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18742
augcacauuc ccacugcuaa                                                   20


<210>  18743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18743
cacugcuaau cagacauggu                                                   20


<210>  18744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18744
ccaugucuga uuagcagugg                                                   20


<210>  18745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18745
acguuuuuau cuguuugccu                                                   20


<210>  18746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18746
uggcccacug guuaaaacuc                                                   20


<210>  18747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18747
guguuuugau cacauaauac                                                   20


<210>  18748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18748
uuuuuuuuuu uucgagaugu                                                   20


<210>  18749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18749
agaugucacc caggcuggag                                                   20


<210>  18750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18750
gguacgggca ucugauucag                                                   20


<210>  18751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18751
ggacucugcu ccuaacugcg                                                   20


<210>  18752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18752
acaaaaaaua cacaaauuag                                                   20


<210>  18753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18753
uuuggcucau aaagagacuc                                                   20


<210>  18754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18754
aagauuugua uuuuaaugag                                                   20


<210>  18755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18755
agacauugcc cuuccaagau                                                   20


<210>  18756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18756
caaguaacga auuagcagaa                                                   20


<210>  18757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18757
uuacuugaga acuaagauau                                                   20


<210>  18758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18758
gcuaauucgu uacuugagaa                                                   20


<210>  18759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18759
auuuucugcu aauucguuac                                                   20


<210>  18760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18760
gcaaaguuca ggcuuuuaau                                                   20


<210>  18761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18761
ggcuuuuaau ccacuagacu                                                   20


<210>  18762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18762
uuuaaccaaa gccugccugg                                                   20


<210>  18763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18763
uuguuuuccc cagaauacuu                                                   20


<210>  18764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18764
ccagaauacu ugcuaaauug                                                   20


<210>  18765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18765
ggggaaaaca aagaaauaca                                                   20


<210>  18766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18766
gucaacuaca aagauugaaa                                                   20


<210>  18767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18767
cacaaauacc cucagguuug                                                   20


<210>  18768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18768
cuagaaugau ucagagaacu                                                   20


<210>  18769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18769
agugaauuau caaaccugag                                                   20


<210>  18770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18770
gagaacucug gaaggcgcua                                                   20


<210>  18771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18771
cugaaucauu cuagugaauu                                                   20


<210>  18772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18772
agaguucucu gaaucauucu                                                   20


<210>  18773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18773
aaagagcacg ugcccuagua                                                   20


<210>  18774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18774
agcacauaac auaugagacu                                                   20


<210>  18775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18775
guaguugaga aacuggauga                                                   20


<210>  18776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18776
ccagaugcuc uggaguggau                                                   20


<210>  18777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18777
caagaccuac acgcugugau                                                   20


<210>  18778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18778
ugaaaggcuc aauuuccaaa                                                   20


<210>  18779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18779
agaaucacag cguguagguc                                                   20


<210>  18780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18780
aaaccucugg auugagacau                                                   20


<210>  18781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18781
aagagauguc ucaauccaga                                                   20


<210>  18782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18782
cccaguucua agagaugucu                                                   20


<210>  18783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18783
aaucaggagu ggucagaacg                                                   20


<210>  18784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18784
gaccacuccu gauuagaagc                                                   20


<210>  18785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18785
gugacuccac guucugacca                                                   20


<210>  18786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18786
cagacgccuu cugugacucc                                                   20


<210>  18787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18787
cggucccagc guugccuguc                                                   20


<210>  18788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18788
uuuuuuccau aggcaugcug                                                   20


<210>  18789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18789
auaggcaugc ugugugugcc                                                   20


<210>  18790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18790
gacacaggga uuggggucgg                                                   20


<210>  18791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18791
gagucagggg ggccucuguu                                                   20


<210>  18792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18792
agaauuucaa acaaaggcug                                                   20


<210>  18793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18793
agaacaacag aguugcagua                                                   20


<210>  18794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18794
aacaaaggcu gaacccuagg                                                   20


<210>  18795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18795
gccuuuguuu gaaauucuag                                                   20


<210>  18796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18796
uaggguucag ccuuuguuug                                                   20


<210>  18797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18797
uaguggugug uuuuccuagg                                                   20


<210>  18798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18798
ucuuaguggu guguuuuccu                                                   20


<210>  18799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18799
auaaaucacu caggacaauc                                                   20


<210>  18800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18800
ucaauaaauc acucaggaca                                                   20


<210>  18801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18801
cucacuuuug uucuucaaua                                                   20


<210>  18802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18802
uucccucacu uuuguucuuc                                                   20


<210>  18803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18803
uuuucuuucc cucacuuuug                                                   20


<210>  18804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18804
cuucuuuuuc uuucccucac                                                   20


<210>  18805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18805
cuuuccuccu gucuggccua                                                   20


<210>  18806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18806
uccugucugg ccuaaggaga                                                   20


<210>  18807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18807
ccuuaggcca gacaggagga                                                   20


<210>  18808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18808
cucccucccc aacggaaagg                                                   20


<210>  18809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18809
guuggggagg gagggaacac                                                   20


<210>  18810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18810
gagacacguc uuuaugcagc                                                   20


<210>  18811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18811
agugagucua gauggauuuu                                                   20


<210>  18812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18812
uccagugagu cuagauggau                                                   20


<210>  18813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18813
uacagauauu uuccaaauga                                                   20


<210>  18814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18814
aaaugaacag aaaccuaacc                                                   20


<210>  18815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18815
uuuggaaaau aucuguauga                                                   20


<210>  18816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18816
guucauuugg aaaauaucug                                                   20


<210>  18817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18817
agccuugguu agguuucugu                                                   20


<210>  18818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18818
cuaaagccaa auuccagccu                                                   20


<210>  18819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18819
ggcuucucua aagccaaauu                                                   20


<210>  18820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18820
ucuggcuucu cuaaagccaa                                                   20


<210>  18821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18821
uuuacuuugg gaggugacug                                                   20


<210>  18822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18822
uaccagucac cucccaaagu                                                   20


<210>  18823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18823
ggcucuuacu cagagccuuc                                                   20


<210>  18824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18824
cauguaaauu caucacugug                                                   20


<210>  18825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18825
ucacugugau ggaaagcagu                                                   20


<210>  18826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18826
aucacaguga ugaauuuaca                                                   20


<210>  18827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18827
aaugcgcagc ugagaacuug                                                   20


<210>  18828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18828
cagcugcgca uuggaaaugc                                                   20


<210>  18829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18829
caauagauca gggcuagagg                                                   20


<210>  18830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18830
gcccaagaag caauucggag                                                   20


<210>  18831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18831
uaccagguga ccccaguacc                                                   20


<210>  18832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18832
cucucugcuu ccuaccaggu                                                   20


<210>  18833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18833
gguaacuacc auguaacucc                                                   20


<210>  18834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18834
uuuuuaaguu guuguuaaaa                                                   20


<210>  18835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18835
cagauauacu uacuggcagg                                                   20


<210>  18836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18836
ugcuuuaaaa auaauaauaa                                                   20


<210>  18837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18837
aaaacaaauu uuuauuauua                                                   20


<210>  18838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18838
uccuuuccua ucaagaagga                                                   20


<210>  18839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18839
uaucaagaag gagaggacuu                                                   20


<210>  18840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18840
ugauaggaaa ggaugaaggu                                                   20


<210>  18841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18841
cugccagagu uccaaggcag                                                   20


<210>  18842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18842
aaggcagggu caugagauuc                                                   20


<210>  18843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18843
caauuuuaug auuguaaaua                                                   20


<210>  18844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18844
uucacaauuu uaugauugua                                                   20


<210>  18845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18845
caaaacuaca gauguuuuua                                                   20


<210>  18846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18846
gaaagucuga aaaagaacac                                                   20


<210>  18847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18847
gaacacuaaa aacaucugua                                                   20


<210>  18848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18848
gacuuucuga acacuaaaaa                                                   20


<210>  18849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18849
gccagagaaa agggcucaug                                                   20


<210>  18850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18850
cuggcagaag gauggguaac                                                   20


<210>  18851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18851
ugagcccuuu ucucuggcag                                                   20


<210>  18852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18852
guucaugagc ccuuuucucu                                                   20


<210>  18853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18853
cccucccucu gauuggccca                                                   20


<210>  18854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18854
gcucaggggc acucugugaa                                                   20


<210>  18855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18855
cagagugccc cugagcagaa                                                   20


<210>  18856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18856
caucagcucu guucacagag                                                   20


<210>  18857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18857
cuauccccau uguaaagaug                                                   20


<210>  18858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18858
uucacuaucc ccauuguaaa                                                   20


<210>  18859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18859
uaauacuacu ggccacagua                                                   20


<210>  18860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18860
gagcacuucc uaauacuacu                                                   20


<210>  18861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18861
cagaguacaa uuuucagagc                                                   20


<210>  18862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18862
cccugggaaa uagcuagcag                                                   20


<210>  18863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18863
cagggagaau gcccuuuuug                                                   20


<210>  18864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18864
agacuugggu cuauuuuuug                                                   20


<210>  18865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18865
cauuuauguu uugauuuaug                                                   20


<210>  18866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18866
uaaaucaaaa cauaaaugag                                                   20


<210>  18867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18867
aaggaaagcc uccaggcaca                                                   20


<210>  18868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18868
uuagaaaaug auggaugcgu                                                   20


<210>  18869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18869
ugugccugga ggcuuuccuu                                                   20


<210>  18870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18870
guugugcauu uuuaucauuu                                                   20


<210>  18871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18871
gcauggcuaa caagucaggc                                                   20


<210>  18872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18872
gcaaaguccc agccuguuga                                                   20


<210>  18873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18873
ucagcaaagu cccagccugu                                                   20


<210>  18874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18874
uuuauuucuu cagcaaaguc                                                   20


<210>  18875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18875
ggagcuucag cuaacagccu                                                   20


<210>  18876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18876
gcuaacagcc uaccucagau                                                   20


<210>  18877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18877
gagagccuag gagugaaucu                                                   20


<210>  18878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18878
uuggguaggg gguccccuca                                                   20


<210>  18879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18879
aaacucagca uuucuagcuu                                                   20


<210>  18880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18880
agcuuccaau acagauaccu                                                   20


<210>  18881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18881
aauacagaua ccucauuuuu                                                   20


<210>  18882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18882
cauugcaacu cugcccuuua                                                   20


<210>  18883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18883
auaaucaaac ugcuggguuc                                                   20


<210>  18884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18884
ccagcaccag ccaccugucc                                                   20


<210>  18885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18885
uuuccaucuu caggucauua                                                   20


<210>  18886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18886
aucuucaggu cauuacaagg                                                   20


<210>  18887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18887
ggucauuaca agggccuucc                                                   20


<210>  18888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18888
cugaagccaa cuaaauccuu                                                   20


<210>  18889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18889
gggaaggccc uuguaaugac                                                   20


<210>  18890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18890
ccuaauuuug gcaccuccac                                                   20


<210>  18891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18891
agccaagcac agaggaaggg                                                   20


<210>  18892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18892
ucugugcuug gcuggaagcc                                                   20


<210>  18893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18893
uacccuuccu cugugcuugg                                                   20


<210>  18894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18894
uucauacccu uccucugugc                                                   20


<210>  18895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18895
aauagccuca aagcaagauc                                                   20


<210>  18896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18896
ugugaucuug cuuugaggcu                                                   20


<210>  18897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18897
gcaagacugc acgacauuuu                                                   20


<210>  18898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18898
uuuuucuuuu uucuuuuuuu                                                   20


<210>  18899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18899
uuuuucuuuu uuuuuuuuuu                                                   20


<210>  18900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18900
uuuuuuuuuu uuuuuggaga                                                   20


<210>  18901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18901
agaagacaaa uggacuaacc                                                   20


<210>  18902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18902
ggaaaaaugu uguggcuggg                                                   20


<210>  18903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18903
uagucccagg aucaauauga                                                   20


<210>  18904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18904
uuuaugaagu agagucuaua                                                   20


<210>  18905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18905
ugcucaugca aaggacaagc                                                   20


<210>  18906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18906
uccuccauug aaaggaaagg                                                   20


<210>  18907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18907
auggaggagg aagcuugucc                                                   20


<210>  18908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18908
uuucaaugga ggaggaagcu                                                   20


<210>  18909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18909
uuuccuuuca auggaggagg                                                   20


<210>  18910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18910
cccuuccuuu ccuuucaaug                                                   20


<210>  18911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18911
ugccucacgg aaggugagag                                                   20


<210>  18912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18912
gugaggcagg aagccccagc                                                   20


<210>  18913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18913
gucucccucu cccucucuca                                                   20


<210>  18914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18914
uuuuugaagc agaggucacu                                                   20


<210>  18915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18915
uggcaguuau ucauuuuuga                                                   20


<210>  18916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18916
uuugcugugg cucuccgcau                                                   20


<210>  18917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18917
agggucagau guuuacagag                                                   20


<210>  18918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18918
cuguaaacau cugacccuag                                                   20


<210>  18919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18919
agcacuggca ccugccugcc                                                   20


<210>  18920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18920
agcaaauuuu auuuaugcac                                                   20


<210>  18921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18921
agugugcaua aauaaaauuu                                                   20


<210>  18922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18922
aauuccagug ugcauaaaua                                                   20


<210>  18923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18923
uauaauuuuc aggugucacc                                                   20


<210>  18924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18924
ggugucacca aagagugucc                                                   20


<210>  18925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18925
uuugauuuuu uuucaacuau                                                   20


<210>  18926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18926
acuauuuaaa auuguaaaac                                                   20


<210>  18927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18927
uagcucacaa gccacgcaaa                                                   20


<210>  18928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18928
caugcauauu uuaauacuga                                                   20


<210>  18929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18929
guauuaaaau augcauggga                                                   20


<210>  18930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18930
uauaaauggu auuauauggu                                                   20


<210>  18931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18931
cuucuacagc ugaucacucu                                                   20


<210>  18932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18932
acagcugauc acucuuuuuc                                                   20


<210>  18933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18933
acaucaaauu ugcugagauu                                                   20


<210>  18934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18934
guuaauucau cuuaacugcu                                                   20


<210>  18935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18935
ucuuaacugc uguauaggaa                                                   20


<210>  18936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18936
augauggucu uuuuuaauuu                                                   20


<210>  18937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18937
cucccugauc acucacaggu                                                   20


<210>  18938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18938
ugggcuccca cugaccagca                                                   20


<210>  18939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18939
cucucugggu uaaaugugaa                                                   20


<210>  18940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18940
cauuuaaccc agagagagaa                                                   20


<210>  18941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18941
gagccauuca cauuuaaccc                                                   20


<210>  18942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18942
agcauguauu ucugagccau                                                   20


<210>  18943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18943
ucaugugcag cacucagggu                                                   20


<210>  18944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18944
ccccacaccc cagugguuca                                                   20


<210>  18945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18945
accuucaauu uuucuaauau                                                   20


<210>  18946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18946
auuuuucuaa uauacaauua                                                   20


<210>  18947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18947
aauauacaau uacauucauu                                                   20


<210>  18948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18948
uuuucaguug ccaccaaaau                                                   20


<210>  18949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18949
guugccacca aaauaaauua                                                   20


<210>  18950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18950
gggccaguug aacucaguug                                                   20


<210>  18951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18951
acuggcccag aaacugagau                                                   20


<210>  18952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18952
ccagaaccuu uaggaggaag                                                   20


<210>  18953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18953
uccccagaac cuuuaggagg                                                   20


<210>  18954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18954
agcuugucca gguugcuggc                                                   20


<210>  18955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18955
gccagcaacc uggacaagcu                                                   20


<210>  18956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18956
guuucuugug gcuagaggac                                                   20


<210>  18957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18957
uguggcuaga ggacugcugu                                                   20


<210>  18958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18958
cucaagacau cucagauauc                                                   20


<210>  18959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18959
caccuuuccc ucaagacauc                                                   20


<210>  18960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18960
ucugucacua ugugcuaaaa                                                   20


<210>  18961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18961
caguggccaa gaaucagaaa                                                   20


<210>  18962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18962
uggccacugu gaaggcacag                                                   20


<210>  18963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18963
gauucuuggc cacugugaag                                                   20


<210>  18964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18964
gcuaaaacaa gaguguaggg                                                   20


<210>  18965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18965
ucagcuaaaa caagagugua                                                   20


<210>  18966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18966
uaacguucuu cagcuaaaac                                                   20


<210>  18967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18967
uuucuuaacg uucuucagcu                                                   20


<210>  18968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18968
cuuucgaggu acuguuuacu                                                   20


<210>  18969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18969
agguacuguu uacugaggug                                                   20


<210>  18970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18970
uguguuuggg uccagcagga                                                   20


<210>  18971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18971
gaggcucuca acuccugcug                                                   20


<210>  18972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18972
ugugcaagac uuuacacauu                                                   20


<210>  18973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18973
aucaauccgg caccuauggg                                                   20


<210>  18974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18974
ugucccauag gugccggauu                                                   20


<210>  18975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18975
uuuuuauuug gcuaucuggc                                                   20


<210>  18976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18976
ugaaguuaau uaaugcugag                                                   20


<210>  18977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18977
ggaaaguaaa aggugauucu                                                   20


<210>  18978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18978
cugagcaaag acuccacauu                                                   20


<210>  18979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18979
ucuguaccuc ccagcuaggc                                                   20


<210>  18980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18980
cuucacacuc cuucuggugu                                                   20


<210>  18981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18981
cacuccuucu gguguuuccc                                                   20


<210>  18982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18982
gguguuuccc uucugggucu                                                   20


<210>  18983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18983
cuucuggguc uuauuuuuau                                                   20


<210>  18984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18984
gggucuuauu uuuauucauu                                                   20


<210>  18985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18985
uuuuuccagu uuauaaaaca                                                   20


<210>  18986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18986
aguuuauaaa acacacucac                                                   20


<210>  18987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18987
acaugugccc caagggccca                                                   20


<210>  18988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18988
ugacucuaag ucagucuguu                                                   20


<210>  18989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18989
uaggguuuug guucuugacu                                                   20


<210>  18990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18990
ccucuaucuc gcccccaccc                                                   20


<210>  18991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18991
ccucccauau uuccuaaaag                                                   20


<210>  18992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18992
uaaaaggucc auaaaguugg                                                   20


<210>  18993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18993
aaaggaaagg gagguaggua                                                   20


<210>  18994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18994
uuuggaaaaa gcccaacuuu                                                   20


<210>  18995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18995
gauaccuacc ucccuuuccu                                                   20


<210>  18996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18996
cuuaauaucu ugauccaagg                                                   20


<210>  18997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18997
cggagccugg ugcuguagcc                                                   20


<210>  18998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18998
agcaaccccu uugccaaacc                                                   20


<210>  18999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  18999
ggaggcuguc cagggccugg                                                   20


<210>  19000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19000
uaggagugac ccggauguuc                                                   20


<210>  19001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19001
cacaucagga agggaaauaa                                                   20


<210>  19002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19002
ugauguggga aaucugagcu                                                   20


<210>  19003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19003
cuuccugaug ugggaaaucu                                                   20


<210>  19004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19004
uaggccgggc gcagcaucuc                                                   20


<210>  19005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19005
uugagggccc aaacaagaug                                                   20


<210>  19006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19006
aaggcccaau cuucccuccc                                                   20


<210>  19007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19007
cucccuuuua aaaagugugc                                                   20


<210>  19008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19008
agagcacacu cuuuuuuuug                                                   20


<210>  19009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19009
ucagaugauc agucagcugu                                                   20


<210>  19010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19010
ccuaaagugc acgaggccca                                                   20


<210>  19011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19011
ucuggggggu caaggaaggc                                                   20


<210>  19012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19012
uugacccccc agaugaaguc                                                   20


<210>  19013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19013
gagggcagac auucaagcug                                                   20


<210>  19014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19014
agcuggaaac ugaaggacac                                                   20


<210>  19015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19015
agcuugaaug ucugcccuca                                                   20


<210>  19016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19016
guuuccagcu ugaaugucug                                                   20


<210>  19017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19017
ccuguuuaac uccauguguc                                                   20


<210>  19018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19018
uccacuguuc accuguuuaa                                                   20


<210>  19019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19019
ccauggugcc ugccucaaaa                                                   20


<210>  19020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19020
gucuucucca uggugccugc                                                   20


<210>  19021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19021
cguuuuuaaa aagaucucuc                                                   20


<210>  19022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19022
agaccacccu gggcaauaug                                                   20


<210>  19023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19023
ccauauugcc cagggugguc                                                   20


<210>  19024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19024
uaugccucag ccuccugggu                                                   20


<210>  19025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19025
agcaauucuu augccucagc                                                   20


<210>  19026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19026
agggagaguu uuuuuuuuuu                                                   20


<210>  19027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19027
uggagcucug agaaacgugg                                                   20


<210>  19028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19028
cagagcucca ggaacaacag                                                   20


<210>  19029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19029
aaccacguuu cucagagcuc                                                   20


<210>  19030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19030
ucagguuggc ccuuuucaaa                                                   20


<210>  19031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19031
uuuccaucag ugauugacuu                                                   20


<210>  19032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19032
aucagugauu gacuuuugug                                                   20


<210>  19033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19033
gaugguuugc ugagaauguu                                                   20


<210>  19034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19034
cagcaaacca ucugaaugca                                                   20


<210>  19035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19035
ugucugccag agcaacauuc                                                   20


<210>  19036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19036
cuuucguguc ugccagagca                                                   20


<210>  19037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19037
cacauucucu uucgugucug                                                   20


<210>  19038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19038
ggagcaccau gaauguagac                                                   20


<210>  19039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19039
uggugcucca gaacuguguc                                                   20


<210>  19040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19040
ugguuaccca guguggggau                                                   20


<210>  19041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19041
ggugagaccc gcucuuccug                                                   20


<210>  19042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19042
ugaggggcgc uucaggcacc                                                   20


<210>  19043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19043
ggcaccagag gccccugcuc                                                   20


<210>  19044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19044
gccaggccaa ccagacuccu                                                   20


<210>  19045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19045
aaucucuggu gguugaggag                                                   20


<210>  19046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19046
ucuaaucucu ggugguugag                                                   20


<210>  19047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19047
ucacuugauu uagaggcaau                                                   20


<210>  19048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19048
caaaccucag gacaaaucgu                                                   20


<210>  19049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19049
uccugaggca aagaaaaaca                                                   20


<210>  19050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19050
ugaggcaaag aaaaacaaaa                                                   20


<210>  19051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19051
uugccucagg aagaaugugu                                                   20


<210>  19052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19052
ucugggcagg aggagucaaa                                                   20


<210>  19053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19053
agaagaacac uguucuccag                                                   20


<210>  19054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19054
ggaagcuucc ucugggcagg                                                   20


<210>  19055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19055
ucuggaagcu uccucugggc                                                   20


<210>  19056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19056
ccaguggcug uugggcugug                                                   20


<210>  19057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19057
caggaaaggg aagugggguc                                                   20


<210>  19058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19058
ugugaaaaau accacagccc                                                   20


<210>  19059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19059
cuuuccugug aaaaauacca                                                   20


<210>  19060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19060
cacagagacc ccacuucccu                                                   20


<210>  19061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19061
ggggaccugg ggcagguggc                                                   20


<210>  19062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19062
gcuccagcuc ucuucacaga                                                   20


<210>  19063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19063
cagacccuga guggggagag                                                   20


<210>  19064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19064
uccugcuucc auccuucaug                                                   20


<210>  19065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19065
auccuucaug cagugcauga                                                   20


<210>  19066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19066
ugcagugcau gaauaaauga                                                   20


<210>  19067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19067
ugcacugcau gaaggaugga                                                   20


<210>  19068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19068
uuuauucaug cacugcauga                                                   20


<210>  19069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19069
cuuucauuua uucaugcacu                                                   20


<210>  19070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19070
gcugaguaca ccuucucuuu                                                   20


<210>  19071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19071
uuucagcuga guacaccuuc                                                   20


<210>  19072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19072
uuuuuauuuu ccuuucagcu                                                   20


<210>  19073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19073
cuucuuuuuu auuuuccuuu                                                   20


<210>  19074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19074
uguuuuggcc gggggggugu                                                   20


<210>  19075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19075
aaaagccauu gcauagguua                                                   20


<210>  19076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19076
cuggggcgau uuuaaccuau                                                   20


<210>  19077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19077
uggucauuua uuugagcuuu                                                   20


<210>  19078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19078
auuaagcacc acagcccaag                                                   20


<210>  19079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19079
caaaggaggc caucagcuaa                                                   20


<210>  19080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19080
uagcugaugg ccuccuuugu                                                   20


<210>  19081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19081
guuaaugaug acugagggug                                                   20


<210>  19082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19082
ccacccucag ucaucauuaa                                                   20


<210>  19083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19083
cuuucuccac ccucagucau                                                   20


<210>  19084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19084
ccuucucuuu cuccacccuc                                                   20


<210>  19085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19085
ucuccuucuc uuucuccacc                                                   20


<210>  19086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19086
cuucuauuuu ucacaacugc                                                   20


<210>  19087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19087
auuuuucaca acugccccug                                                   20


<210>  19088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19088
caacugcccc ugcuuuuccc                                                   20


<210>  19089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19089
cuguuccccc uccucuguug                                                   20


<210>  19090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19090
cccuccucug uugaacagua                                                   20


<210>  19091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19091
acagaggagg gggaacaggg                                                   20


<210>  19092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19092
guacuguuca acagaggagg                                                   20


<210>  19093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19093
uacccagucu gccuuaccug                                                   20


<210>  19094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19094
caaaugaucc uuucuuaccc                                                   20


<210>  19095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19095
aaacuccuuu ucccaaauga                                                   20


<210>  19096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19096
uccugacacc uuguugccaa                                                   20


<210>  19097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19097
ugacaccuug uugccaacag                                                   20


<210>  19098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19098
ugugugcaug cuggugacug                                                   20


<210>  19099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19099
ccacaagcca agagguaaaa                                                   20


<210>  19100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19100
gcuccccaca cuuaaaugca                                                   20


<210>  19101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19101
guggcucacg ccuguaauuc                                                   20


<210>  19102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19102
aacacuuugg gaggcugagg                                                   20


<210>  19103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19103
agaccagccu ggcugacaug                                                   20


<210>  19104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19104
gaguuacugu ggaagaggug                                                   20


<210>  19105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19105
ugcacuccuc ugcucccagg                                                   20


<210>  19106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19106
ugggagcaga ggagugcaug                                                   20


<210>  19107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19107
aucuuauuug ucauguguaa                                                   20


<210>  19108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19108
ccugccucaa ccuccccagu                                                   20


<210>  19109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19109
agugauucuc cugccucaac                                                   20


<210>  19110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19110
caaccagagg caauuucacc                                                   20


<210>  19111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19111
cccuccacuc ccaaggacau                                                   20


<210>  19112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19112
ccugcccaaa augucaacag                                                   20


<210>  19113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19113
uaaccucugc acuguugaca                                                   20


<210>  19114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19114
gagguucuua accucugcac                                                   20


<210>  19115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19115
cagagcaagg auaucccauu                                                   20


<210>  19116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19116
gcuaauugau uuguagaaga                                                   20


<210>  19117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19117
acaaaucaau uagcagaaua                                                   20


<210>  19118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19118
gaacuuguuu guuuuacuuu                                                   20


<210>  19119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19119
gaaugcaaau uauuuacauu                                                   20


<210>  19120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19120
cacccuuuag uccccgggaa                                                   20


<210>  19121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19121
cggggacuaa agggugugaa                                                   20


<210>  19122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19122
uaaacugguu aagaagcaaa                                                   20


<210>  19123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19123
uaaccaguuu augaaacacu                                                   20


<210>  19124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19124
ggaauaaugu auuuuuuaaa                                                   20


<210>  19125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19125
ugaaaauuug cuucuuaacc                                                   20


<210>  19126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19126
ugccugagua gcagcaagca                                                   20


<210>  19127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19127
gcugugguug ucgucagccu                                                   20


<210>  19128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19128
aagagcuuua acuaaacaaa                                                   20


<210>  19129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19129
agcacggugc uuggcacaga                                                   20


<210>  19130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19130
ucuuacaaac cccauaugga                                                   20


<210>  19131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19131
cuuucucagg aggggguggg                                                   20


<210>  19132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19132
caggaggggg ugggggucaa                                                   20


<210>  19133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19133
gagguguccg acugugccgu                                                   20


<210>  19134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19134
cagacaggga guggacagcc                                                   20


<210>  19135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19135
uuaacucaga ggucagcaga                                                   20


<210>  19136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19136
caggacucug uccgccucuu                                                   20


<210>  19137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19137
ucccccacac ccuuccagau                                                   20


<210>  19138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19138
agaugcucuc gaguccucug                                                   20


<210>  19139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19139
ccacugagga uguucuggcu                                                   20


<210>  19140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19140
ucauaauuaa gauuccccac                                                   20


<210>  19141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19141
aacuuccugg aguucagagg                                                   20


<210>  19142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19142
uggaguucag agggguccag                                                   20


<210>  19143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19143
gaggggucca gugugugcau                                                   20


<210>  19144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19144
uaacccgaga agcuucaaac                                                   20


<210>  19145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19145
cggguuauga agggaugaua                                                   20


<210>  19146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19146
aaccuuuaaa gaauuagaua                                                   20


<210>  19147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19147
uuaaagguuu gaagcuucuc                                                   20


<210>  19148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19148
uuccuuuaaa aaaaaaaaau                                                   20


<210>  19149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19149
gcuucucccu aaaauguguu                                                   20


<210>  19150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19150
cccuaaaaug uguuuacccu                                                   20


<210>  19151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19151
ggguaaacac auuuuaggga                                                   20


<210>  19152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19152
guaagguuaa uucaggguaa                                                   20


<210>  19153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19153
cuagggagca agaggagggc                                                   20


<210>  19154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19154
ucagaagauu gaccauauau                                                   20


<210>  19155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19155
gaugaaaagg cugaggguua                                                   20


<210>  19156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19156
ugauaaggau gaggggccaa                                                   20


<210>  19157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19157
cccaggcugg cuucagucca                                                   20


<210>  19158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19158
guccagaagc ucagcucagc                                                   20


<210>  19159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19159
ggacugaagc cagccuggga                                                   20


<210>  19160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19160
cuauguccag ucugcuucca                                                   20


<210>  19161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19161
agaauccagg acacucccau                                                   20


<210>  19162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19162
ggaagcagac uggacauagg                                                   20


<210>  19163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19163
aaaugcaggg ccaccaccaa                                                   20


<210>  19164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19164
ucccaccaga gguugcugcc                                                   20


<210>  19165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19165
aaugccaagu ucuucccacc                                                   20


<210>  19166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19166
agccugucua auucaaaugc                                                   20


<210>  19167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19167
auucaagccu gucuaauuca                                                   20


<210>  19168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19168
ucccauacug gcugugugau                                                   20


<210>  19169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19169
gagagguuaa guaacucagc                                                   20


<210>  19170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19170
ucauguguaa aacauuuaaa                                                   20


<210>  19171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19171
uguguaaaac auuuaaauca                                                   20


<210>  19172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19172
uauuuauaug ucagaggagu                                                   20


<210>  19173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19173
uaaguaaaau aagcuuaaaa                                                   20


<210>  19174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19174
ccaguuuuua agcuuauuuu                                                   20


<210>  19175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19175
uaggagguuu gcaugacagc                                                   20


<210>  19176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19176
uuaccauggg uagggaaaaa                                                   20


<210>  19177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19177
cuacccaugg uaaagaauau                                                   20


<210>  19178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19178
uguaaagggc cagauaguaa                                                   20


<210>  19179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19179
ugacuuuuga gcaucacagg                                                   20


<210>  19180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19180
gagguauccc ugugaugcuc                                                   20


<210>  19181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19181
cacugaaguc ugggggagca                                                   20


<210>  19182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19182
gugugaaaua uggcaagauc                                                   20


<210>  19183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19183
aaaaucaagc aaaaagcagg                                                   20


<210>  19184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19184
caaguucuaa aaucaagcaa                                                   20


<210>  19185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19185
gugugggaga ugucugcuca                                                   20


<210>  19186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19186
cuacucuuaa aaauuugggu                                                   20


<210>  19187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19187
uguuuucucu acucuuaaaa                                                   20


<210>  19188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19188
ggcaccuugc uucuuugucc                                                   20


<210>  19189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19189
uuguccaagc aggucauuaa                                                   20


<210>  19190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19190
uaaauagauc aaggucaauu                                                   20


<210>  19191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19191
aaaacggcag cuggucuaaa                                                   20


<210>  19192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19192
ggaaggauuc cauaaugcau                                                   20


<210>  19193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19193
agaaaccgag caguaccccc                                                   20


<210>  19194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19194
auaaugcaug gaggagugaa                                                   20


<210>  19195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19195
cuccuccaug cauuauggaa                                                   20


<210>  19196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19196
gcagcuuccu aaaauuaggg                                                   20


<210>  19197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19197
uaaaauuagg gaaaucgugu                                                   20


<210>  19198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19198
cuaauuuuag gaagcugcag                                                   20


<210>  19199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19199
ccugagcccu gguagauauc                                                   20


<210>  19200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19200
ccucuggcuu uggucaccag                                                   20


<210>  19201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19201
gcggcccaga guucaccucu                                                   20


<210>  19202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19202
uuucugcggc ccagaguuca                                                   20


<210>  19203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19203
ccuguuccug ccccgcucca                                                   20


<210>  19204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19204
ugccccgcuc cacagggcaa                                                   20


<210>  19205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19205
gagagcagcg auuauggcuu                                                   20


<210>  19206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19206
aaugcaucug accgcccagg                                                   20


<210>  19207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19207
ucaccuuuga gguuucagga                                                   20


<210>  19208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19208
ggagaugacc cgacccuggg                                                   20


<210>  19209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19209
aggacacagg cacgaaauac                                                   20


<210>  19210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19210
ugccuguguc cuugaaggug                                                   20


<210>  19211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19211
cccuccugug ccuggucagg                                                   20


<210>  19212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19212
caugccacca cauuaaaaaa                                                   20


<210>  19213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19213
uucauuucuu cugguuuacg                                                   20


<210>  19214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19214
uuucuucugg uuuacgaaaa                                                   20


<210>  19215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19215
ucugguuuac gaaaagcaag                                                   20


<210>  19216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19216
gguuuacgaa aagcaagucu                                                   20


<210>  19217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19217
uaaaccagaa gaaaugaaug                                                   20


<210>  19218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19218
cacccagacu cucagacuug                                                   20


<210>  19219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19219
guaccuuggg gacuguccuc                                                   20


<210>  19220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19220
gagaccaugu uuaauaucac                                                   20


<210>  19221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19221
caguuccgag accauguuua                                                   20


<210>  19222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19222
ccccugccag cccugcccuu                                                   20


<210>  19223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19223
cgccccugcu cccccauuuc                                                   20


<210>  19224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19224
aaucugaaau guagauuugg                                                   20


<210>  19225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19225
gauuugaaau gggggagcag                                                   20


<210>  19226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19226
ucuaaccagg acugaacguu                                                   20


<210>  19227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19227
guccugguua gaggaaggua                                                   20


<210>  19228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19228
gggugugcaa acguucaguc                                                   20


<210>  19229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19229
augcauucag ggugugcaaa                                                   20


<210>  19230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19230
aaacaccacu auagcaguug                                                   20


<210>  19231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19231
cuuacauuug agacuugggu                                                   20


<210>  19232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19232
cuuuaucucc ucgggcuugu                                                   20


<210>  19233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19233
cuucacucuc cuuauucauu                                                   20


<210>  19234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19234
cucuccuuau ucauuccaug                                                   20


<210>  19235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19235
uuccaugucc uuguauuuua                                                   20


<210>  19236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19236
auguccuugu auuuuauuuu                                                   20


<210>  19237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19237
uuuuauuaaa aaauauauau                                                   20


<210>  19238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19238
cuagagcccu ccuuuuuaaa                                                   20


<210>  19239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19239
ugugcuguuu uaaaaaggag                                                   20


<210>  19240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19240
acagccuccc uuaaggugcc                                                   20


<210>  19241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19241
agauguaauu cuaaaccaca                                                   20


<210>  19242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19242
aaaccacaag gaagaauauc                                                   20


<210>  19243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19243
uugugguuua gaauuacauc                                                   20


<210>  19244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19244
uccuuguggu uuagaauuac                                                   20


<210>  19245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19245
gccugugcag cuaaaaaauu                                                   20


<210>  19246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19246
uaaauuuuuu agcugcacag                                                   20


<210>  19247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19247
cacucagacg caggacaccu                                                   20


<210>  19248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19248
gcuggaggag guguccugcg                                                   20


<210>  19249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19249
agccaccaaa ugacaacaga                                                   20


<210>  19250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19250
gaauuaaauu uuccuuuuuu                                                   20


<210>  19251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19251
gaagucuguu gucauuuggu                                                   20


<210>  19252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19252
uuuuuuuccc aauaaaucua                                                   20


<210>  19253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19253
caauaaaucu auagucuuca                                                   20


<210>  19254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19254
cuacccccuu auauuuucua                                                   20


<210>  19255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19255
aaucuccuaa acucauuuaa                                                   20


<210>  19256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19256
agaugccccc ugauagcaag                                                   20


<210>  19257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19257
uuccagaugc ccccugauag                                                   20


<210>  19258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19258
uuguauaagu aaaauuaaaa                                                   20


<210>  19259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19259
aucccacaua caguguaggg                                                   20


<210>  19260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19260
ccuacacugu augugggauc                                                   20


<210>  19261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19261
cccagacaug cuaggagaca                                                   20


<210>  19262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19262
uccauacggu gcucccuguc                                                   20


<210>  19263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19263
ccccgaggcu ucguccauac                                                   20


<210>  19264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19264
ugaggcccca cccugcccag                                                   20


<210>  19265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19265
caggagucau accagacaaa                                                   20


<210>  19266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19266
uaagauuuga ggauucauga                                                   20


<210>  19267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19267
ugauuccuuu uaaaagcaga                                                   20


<210>  19268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19268
uuuuaaaagc agacagaggu                                                   20


<210>  19269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19269
uccucuaccu gucugacagg                                                   20


<210>  19270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19270
ucuaccuguc ugacagggga                                                   20


<210>  19271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19271
ccugucagac agguagagga                                                   20


<210>  19272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19272
ccuucugaga agggguagga                                                   20


<210>  19273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19273
gagaaggggu aggagguggg                                                   20


<210>  19274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19274
cagaagggga auuugggagg                                                   20


<210>  19275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19275
aucuacaugc accaugccau                                                   20


<210>  19276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19276
uuuuugucua caagcagugg                                                   20


<210>  19277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19277
auacuggcuc cuggugacug                                                   20


<210>  19278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19278
gucaccagga gccaguaugg                                                   20


<210>  19279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19279
ugcucaaguc cucacaucac                                                   20


<210>  19280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19280
ggccucccca gggaacuuua                                                   20


<210>  19281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19281
cuggggaggc cugaagccag                                                   20


<210>  19282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19282
caccaggagg uaaaguuccc                                                   20


<210>  19283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19283
guuaugcuaa cuguccccau                                                   20


<210>  19284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19284
ggugacaagu ggccucacca                                                   20


<210>  19285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19285
cacgagggau cuuuugcccc                                                   20


<210>  19286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19286
cuuaccauga gccuuuccca                                                   20


<210>  19287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19287
agggaggugc guucucuuac                                                   20


<210>  19288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19288
ggggagccug uuucguuuuc                                                   20


<210>  19289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19289
uuuuccuguu cugaugaaag                                                   20


<210>  19290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19290
uguucugaug aaagugaccu                                                   20


<210>  19291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19291
gaugaaagug accugcaugu                                                   20


<210>  19292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19292
ucagaacagg aaaacgaaac                                                   20


<210>  19293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19293
ccacggcuua cuguaaagau                                                   20


<210>  19294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19294
agcccuggug guuuugguca                                                   20


<210>  19295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19295
acagguuggg cagggcagcg                                                   20


<210>  19296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19296
ccaggguucu gcccacaggc                                                   20


<210>  19297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19297
gcccacaggc ugagccccug                                                   20


<210>  19298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19298
cccuccuccu uugccaaucc                                                   20


<210>  19299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19299
cccaccuuuc uuggaucauc                                                   20


<210>  19300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19300
uggaucaucu cacacagagu                                                   20


<210>  19301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19301
auagugccca gucuauggcu                                                   20


<210>  19302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19302
cucugacucu aacuugcguu                                                   20


<210>  19303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19303
cacaaacaug uucucucucc                                                   20


<210>  19304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19304
cucuccacau uguauuuucu                                                   20


<210>  19305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19305
guagucaaca aaaauucacc                                                   20


<210>  19306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19306
ccaacuguaa gugcgcaauu                                                   20


<210>  19307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19307
auugcgcacu uacaguuggu                                                   20


<210>  19308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19308
acacaucacu gugcuggugg                                                   20


<210>  19309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19309
caacagccau ggggccugga                                                   20


<210>  19310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19310
aucacuauug uuuugccuug                                                   20


<210>  19311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19311
gaauguaguc uuugugguug                                                   20


<210>  19312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19312
gaaugauugc aaaaugcaaa                                                   20


<210>  19313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19313
uucacauagc auauuccuug                                                   20


<210>  19314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19314
cauagcauau uccuugagau                                                   20


<210>  19315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19315
uugagauuca uccacauugu                                                   20


<210>  19316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19316
uccacauugu ugcaugcauc                                                   20


<210>  19317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19317
guacuucagc ucuuuuuaga                                                   20


<210>  19318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19318
gcucuuuuua gagcugagua                                                   20


<210>  19319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19319
aguguaugga uagaucacaa                                                   20


<210>  19320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19320
cauuuccccu gggaauauag                                                   20


<210>  19321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19321
ccugggaaua uagcuagcag                                                   20


<210>  19322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19322
caggggaaau gagaacauac                                                   20


<210>  19323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19323
agugcauaug uagugauauc                                                   20


<210>  19324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19324
cuaaugacua augauguuca                                                   20


<210>  19325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19325
gcaucuuucc auguguuuau                                                   20


<210>  19326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19326
auguguuuau uugccaugcc                                                   20


<210>  19327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19327
uugguggaau gucuguucaa                                                   20


<210>  19328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19328
accaaagaag gcauggcaaa                                                   20


<210>  19329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19329
aaucuuucgc ucauuuucau                                                   20


<210>  19330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19330
cucauuuuca uuguguugca                                                   20


<210>  19331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19331
uuguguugca uugauuucuu                                                   20


<210>  19332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19332
uacuauugac uuuugagagu                                                   20


<210>  19333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19333
ggauacaagu ucuuuaucag                                                   20


<210>  19334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19334
uuaucagaug uauuuuuugc                                                   20


<210>  19335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19335
cccagucugu cuugucuuuu                                                   20


<210>  19336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19336
aauuauucca gcuccuuuga                                                   20


<210>  19337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19337
agcuccuuug augaaaagau                                                   20


<210>  19338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19338
ucaaaggagc uggaauaauu                                                   20


<210>  19339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19339
cccauuaaac ugcuugugca                                                   20


<210>  19340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19340
guuaaucuua uaugcauggg                                                   20


<210>  19341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19341
auugauccug ucugucugua                                                   20


<210>  19342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19342
aaacuugugg uguuagugua                                                   20


<210>  19343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19343
uuuucaaaau ugcuuuaacu                                                   20


<210>  19344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19344
aaauugcuuu aacuauuuua                                                   20


<210>  19345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19345
acauacauuu uagaaucagu                                                   20


<210>  19346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19346
aaaauguaug uggaaaugca                                                   20


<210>  19347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19347
acaaaaaaag ccugcuggga                                                   20


<210>  19348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19348
cucccuguua uguuuuaagc                                                   20


<210>  19349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19349
uuguccucca ggagcuuaaa                                                   20


<210>  19350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19350
ccaugguucc ugagccauag                                                   20


<210>  19351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19351
ugagccauag uaaacuaugu                                                   20


<210>  19352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19352
cccuccccgc ccccaaucac                                                   20


<210>  19353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19353
gcuuuacccu cucucgcuug                                                   20


<210>  19354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19354
uugccuucug cuuuacccuc                                                   20


<210>  19355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19355
ucauccucac gucugccugu                                                   20


<210>  19356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19356
cauucaucau ccucacgucu                                                   20


<210>  19357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19357
ggcaguggca caaggaagug                                                   20


<210>  19358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19358
uugugccacu gccagaauac                                                   20


<210>  19359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19359
ucucauagcc aaggucacug                                                   20


<210>  19360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19360
cauagccaag gucacuguuu                                                   20


<210>  19361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19361
caaucaggga aaguugcaag                                                   20


<210>  19362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19362
cugauuguga aacagugacc                                                   20


<210>  19363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19363
ggggaucuug caacuuuccc                                                   20


<210>  19364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19364
aggacaagcu aggguuccua                                                   20


<210>  19365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19365
uagagucugg gaucugguga                                                   20


<210>  19366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19366
ccagauccca gacucuagga                                                   20


<210>  19367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19367
uuggcgauug uucaccagau                                                   20


<210>  19368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19368
auucuuuggc gauuguucac                                                   20


<210>  19369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19369
auucuauucu uuggcgauug                                                   20


<210>  19370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19370
ugucugucug acuuuagcuu                                                   20


<210>  19371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19371
uucuagaaag agcuagaaag                                                   20


<210>  19372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19372
agaaagagcu agaaaggucu                                                   20


<210>  19373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19373
agaaggaagc uaaagucaga                                                   20


<210>  19374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19374
agcucuuucu agaaggaagc                                                   20


<210>  19375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19375
uguuuugcuc aucuauaaaa                                                   20


<210>  19376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19376
aguucuuguu uugcucaucu                                                   20


<210>  19377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19377
cuguuuaacu cugugaccuc                                                   20


<210>  19378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19378
uagucuuagg gugcuaccaa                                                   20


<210>  19379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19379
guccucaagg cuguugaccu                                                   20


<210>  19380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19380
gugacguaaa uggcucuggu                                                   20


<210>  19381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19381
aagagcucca guucugugac                                                   20


<210>  19382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19382
ggcacagcca acugauugac                                                   20


<210>  19383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19383
gacuuucugg cacagccaac                                                   20


<210>  19384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19384
aguccccccg augccuccuc                                                   20


<210>  19385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19385
ugugcaucua ucaacacaag                                                   20


<210>  19386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19386
uaauaauguc uuguguugau                                                   20


<210>  19387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19387
caucaaaauc cccucuauaa                                                   20


<210>  19388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19388
cugccauuug cuucaagcca                                                   20


<210>  19389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19389
agccagcuuu ggccuuccca                                                   20


<210>  19390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19390
cagguauuuu ggugagaugg                                                   20


<210>  19391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19391
gguuuauagc ccaucccauc                                                   20


<210>  19392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19392
cuguaucuuc cauuauaugc                                                   20


<210>  19393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19393
ucccuguauc uuccauuaua                                                   20


<210>  19394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19394
ggaguguguu aucuucuucc                                                   20


<210>  19395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19395
gaaaccucac ugccagaagc                                                   20


<210>  19396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19396
gaaaaaguuu guuucuggag                                                   20


<210>  19397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19397
ggcagugagg uuucagaaaa                                                   20


<210>  19398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19398
ugcuucuggc agugagguuu                                                   20


<210>  19399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19399
uggaagacuc aaaacucagu                                                   20


<210>  19400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19400
aggaaccaga guugaauccu                                                   20


<210>  19401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19401
aggcucacug aguuuugagu                                                   20


<210>  19402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19402
aaccacaaau ggcuuuaaaa                                                   20


<210>  19403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19403
gcuacccauu agcgacaugg                                                   20


<210>  19404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19404
caccuccccc cuccaaggag                                                   20


<210>  19405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19405
ccuuggaggg gggagguggg                                                   20


<210>  19406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19406
cucaaagaca agacaguaug                                                   20


<210>  19407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19407
augcaaauug aguguccaga                                                   20


<210>  19408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19408
cucuggacac ucaauuugca                                                   20


<210>  19409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19409
ccauggcuga guugcuggag                                                   20


<210>  19410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19410
aagcuguuaa cgcauuuuau                                                   20


<210>  19411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19411
ggguaacagc aaugauuaau                                                   20


<210>  19412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19412
uaggccauuc aggguaacag                                                   20


<210>  19413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19413
aggcccucuu cugugaaaac                                                   20


<210>  19414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19414
gugaaaacua uggaugccau                                                   20


<210>  19415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19415
cagaagaggg ccuggaaaau                                                   20


<210>  19416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19416
aauuaucacu acuacauuuu                                                   20


<210>  19417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19417
cugucuccaa aauaugcccc                                                   20


<210>  19418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19418
aggauggggg cauauuuugg                                                   20


<210>  19419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19419
caguuaucua caacaguuua                                                   20


<210>  19420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19420
caugauauga aaauucucaa                                                   20


<210>  19421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19421
uaucauguga aauucccagu                                                   20


<210>  19422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19422
uccuacaugg gcgucuauag                                                   20


<210>  19423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19423
ucaauggcua guggcugggg                                                   20


<210>  19424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19424
uuguggguug uuggauugag                                                   20


<210>  19425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19425
augguuuuau ugccuaaaua                                                   20


<210>  19426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19426
cagggauguu uucuccauaa                                                   20


<210>  19427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19427
ccauaagaua aucagauuuu                                                   20


<210>  19428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19428
gugagguggu ccugcccaca                                                   20


<210>  19429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19429
caccaucgcc cacccauugu                                                   20


<210>  19430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19430
auuccucaaa aagauagcua                                                   20


<210>  19431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19431
ucaaaaagau agcuacuaac                                                   20


<210>  19432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19432
uuguagacaa auugugaggg                                                   20


<210>  19433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19433
uuguggacaa augacagaca                                                   20


<210>  19434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19434
cugggaaagg cuaaucagac                                                   20


<210>  19435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19435
cagggaagca aucagauaug                                                   20


<210>  19436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19436
uuugaguguc ugauuagccu                                                   20


<210>  19437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19437
guaccuauga ccuggaaacc                                                   20


<210>  19438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19438
aggucauagg uacagaagag                                                   20


<210>  19439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19439
ugcugcgagu ugucccaccu                                                   20


<210>  19440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19440
aaaccaagcc aauguaaauc                                                   20


<210>  19441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19441
aguucuagau cccugaggaa                                                   20


<210>  19442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19442
caauagcaaa gacuuggaac                                                   20


<210>  19443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19443
aagucuuugc uauugugaau                                                   20


<210>  19444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19444
uaauccaguc uaucauuguu                                                   20


<210>  19445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19445
augguguaua ugugccacau                                                   20


<210>  19446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19446
uguccuuugu agggacauag                                                   20


<210>  19447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19447
uaucccuauu auacugguag                                                   20


<210>  19448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19448
uugugccagg aacuuugcaa                                                   20


<210>  19449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19449
uggcacaaag aaguugcuca                                                   20


<210>  19450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19450
uucagauccu caccacaacc                                                   20


<210>  19451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19451
gauccucacc acaacccugg                                                   20


<210>  19452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19452
ccaggguugu ggugaggauc                                                   20


<210>  19453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19453
aaccucagcu cugacaugug                                                   20


<210>  19454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19454
augucauuaa acuuuuuuug                                                   20


<210>  19455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19455
aaaaaaguuu aaugacaugg                                                   20


<210>  19456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19456
auuguugagu ggauuugccc                                                   20


<210>  19457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19457
cuuauuuuuc cagccuuuaa                                                   20


<210>  19458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19458
agccuuuaag cuguuuccag                                                   20


<210>  19459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19459
uaggcuagag cacuagagga                                                   20


<210>  19460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19460
aacuugaccu ggcagucccu                                                   20


<210>  19461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19461
cgaaagguug uaccaauuca                                                   20


<210>  19462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19462
ggaaagcaau uuggcaacug                                                   20


<210>  19463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19463
uauucccaag gagauaaaca                                                   20


<210>  19464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19464
caaggagaua aacacuuaac                                                   20


<210>  19465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19465
aaguuaagug uuuaucuccu                                                   20


<210>  19466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19466
uuucaaaguu aaguguuuau                                                   20


<210>  19467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19467
uuuaaacaag gugccggcuu                                                   20


<210>  19468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19468
gcacaaaggc ccucagaacc                                                   20


<210>  19469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19469
gagggccuuu gugcggaacu                                                   20


<210>  19470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19470
cagggguucu gagggccuuu                                                   20


<210>  19471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19471
ucagcccaug guucacaggg                                                   20


<210>  19472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19472
gccuuccuga cuggcugguu                                                   20


<210>  19473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19473
ugacuggcug guuaaauucc                                                   20


<210>  19474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19474
caacauccca gaugucauuu                                                   20


<210>  19475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19475
gugggguaag gggggaaaug                                                   20


<210>  19476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19476
ccccuuaccc cacugaaucu                                                   20


<210>  19477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19477
auuucccccc uuaccccacu                                                   20


<210>  19478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19478
gguugauuau caugcaaaug                                                   20


<210>  19479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19479
ugagacagcu uuuccagaau                                                   20


<210>  19480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19480
agaauuggau gaccuucucc                                                   20


<210>  19481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19481
ggaaaagcug ucucaagaaa                                                   20


<210>  19482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19482
ccaaguggau aaggauauuu                                                   20


<210>  19483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19483
cugccagauc uuaagcuagg                                                   20


<210>  19484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19484
augcccuagc uuaagaucug                                                   20


<210>  19485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19485
auacacauac acaaagagaa                                                   20


<210>  19486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19486
cuuuguguau guguauagaa                                                   20


<210>  19487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19487
ggguggcuaa auauuugcac                                                   20


<210>  19488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19488
ccucuuucug gguggcuaaa                                                   20


<210>  19489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19489
uuuggccuua gguaccaucu                                                   20


<210>  19490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19490
gaacaaauuu uuuuuaauug                                                   20


<210>  19491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19491
gaaucuuccu uuggccuuag                                                   20


<210>  19492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19492
cuaccccaau uuguuaugca                                                   20


<210>  19493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19493
uuggcuaugu caaugcauaa                                                   20


<210>  19494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19494
aagguuaaaa uaggccaaua                                                   20


<210>  19495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19495
auuuuccuuu gugaauugga                                                   20


<210>  19496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19496
uuugugaauu ggaagaggga                                                   20


<210>  19497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19497
caaaggaaaa uagaaauguu                                                   20


<210>  19498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19498
aauucacaaa ggaaaauaga                                                   20


<210>  19499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19499
ucucucccuc uuccaauuca                                                   20


<210>  19500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19500
uuuccucucu cccucuucca                                                   20


<210>  19501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19501
cuguaguuac uuggauuuuc                                                   20


<210>  19502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19502
caccauaggc uagauauuaa                                                   20


<210>  19503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19503
uaauaucuag ccuauggugu                                                   20


<210>  19504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19504
cuuacaguuc agguagggcu                                                   20


<210>  19505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19505
gguagggcug ggccugcgug                                                   20


<210>  19506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19506
guauucugcc auuauuugaa                                                   20


<210>  19507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19507
gccauuauuu gaaaugcccu                                                   20


<210>  19508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19508
aauaauggca gaauacagaa                                                   20


<210>  19509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19509
gggauaggaa gugacuuagu                                                   20


<210>  19510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19510
uaucccagaa gcuaguuugg                                                   20


<210>  19511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19511
cccccagccc cuaugccugu                                                   20


<210>  19512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19512
ucauuuaaau uucaguauuu                                                   20


<210>  19513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19513
guauuuacuu aauagggacc                                                   20


<210>  19514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19514
gucaguuuua aaaccagcaa                                                   20


<210>  19515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19515
caggcauacc agcauggcug                                                   20


<210>  19516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19516
cauaggguuu uggauggaug                                                   20


<210>  19517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19517
cacuagucac caccaguggc                                                   20


<210>  19518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19518
uagccaucac auuuaaucuc                                                   20


<210>  19519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19519
ucugggacuc caccccacaa                                                   20


<210>  19520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19520
gggacuccac cccacaacuu                                                   20


<210>  19521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19521
aaccucuccu guccaacugc                                                   20


<210>  19522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19522
cagaggaggc uguuguggug                                                   20


<210>  19523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19523
gagaagcuga guuaaauacc                                                   20


<210>  19524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19524
cagaaguugc caauaaacuu                                                   20


<210>  19525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19525
aguugauuuc auagaacugu                                                   20


<210>  19526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19526
uagaacuguc auuucuguuc                                                   20


<210>  19527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19527
cugaaaacca accugacacc                                                   20


<210>  19528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19528
gagaacagaa augacaguuc                                                   20


<210>  19529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19529
accaaugaaa caccugcuua                                                   20


<210>  19530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19530
uugguugaag aggucauugc                                                   20


<210>  19531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19531
cuuaaaaaau aauacauugg                                                   20


<210>  19532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19532
guucccuuaa aaaauaauac                                                   20


<210>  19533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19533
gugcgugauc aaaaccuuuu                                                   20


<210>  19534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19534
gcuaguagca uauggcucuu                                                   20


<210>  19535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19535
caagagccau augcuacuag                                                   20


<210>  19536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19536
ucaauuauuu cauuauugua                                                   20


<210>  19537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19537
uuauuguauc accuguguca                                                   20


<210>  19538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19538
uaaaacaaua accaacccaa                                                   20


<210>  19539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19539
acaugcuucc uaaaacaaua                                                   20


<210>  19540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19540
uauucucacc ccucccaguu                                                   20


<210>  19541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19541
caccccuccc aguucuccuu                                                   20


<210>  19542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19542
ccuucuggac uuagagcuag                                                   20


<210>  19543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19543
ggacuuagag cuagucacua                                                   20


<210>  19544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19544
ucugccuuaa uagugacuag                                                   20


<210>  19545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19545
uugucuaacu cccacguuca                                                   20


<210>  19546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19546
cuauuugagg guugaaaggc                                                   20


<210>  19547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19547
acccucaaau agugaagagg                                                   20


<210>  19548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19548
auuauaacua ccuggagugg                                                   20


<210>  19549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19549
gccgcucuuc ucuauucaug                                                   20


<210>  19550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19550
cuauucaugg uuccugcaaa                                                   20


<210>  19551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19551
ugguuccugc aaaucuuuuc                                                   20


<210>  19552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19552
ugcaaaucuu uucugugcuc                                                   20


<210>  19553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19553
gugcucugag acccagcuug                                                   20


<210>  19554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19554
cccuucccug aauucauaua                                                   20


<210>  19555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19555
cugaauucau auagcucuua                                                   20


<210>  19556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19556
gggaagggag aauaugucag                                                   20


<210>  19557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19557
uauagcucuu aaauuagcac                                                   20


<210>  19558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19558
uccccuuaga gcacacagag                                                   20


<210>  19559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19559
ccuuagagca cacagagugc                                                   20


<210>  19560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19560
caucaaacau gcugccucca                                                   20


<210>  19561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19561
uaaauuaauu aauuaauaag                                                   20


<210>  19562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19562
gacucaaaaa uccaugcucu                                                   20


<210>  19563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19563
agauaaagac auuggagcuu                                                   20


<210>  19564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19564
uccaagccau guagcauuau                                                   20


<210>  19565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19565
guuauuccuc caagccaugu                                                   20


<210>  19566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19566
uuaccccugc caagugccca                                                   20


<210>  19567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19567
uuuauugacu gucuaaacca                                                   20


<210>  19568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19568
agaguccuau uuuucuuuuu                                                   20


<210>  19569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19569
uuuuaauagu guucauucca                                                   20


<210>  19570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19570
uuccaagaca ugucuaccac                                                   20


<210>  19571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19571
aagacauguc uaccacauuu                                                   20


<210>  19572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19572
ccuaucaauu augaaaaagu                                                   20


<210>  19573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19573
uaauugauag gugaaaauaa                                                   20


<210>  19574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19574
ggaaccaaga cccaaguccc                                                   20


<210>  19575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19575
ugaaaacuuu uucauaauug                                                   20


<210>  19576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19576
uaucugaaaa uaaaaauucc                                                   20


<210>  19577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19577
gauaagaagg cacaucaaca                                                   20


<210>  19578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19578
ccaaacuuaa uacaauuugg                                                   20


<210>  19579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19579
caaauuguau uaaguuuggg                                                   20


<210>  19580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19580
auugucauuu uccuugaaac                                                   20


<210>  19581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19581
uugaaacacu ugguacugug                                                   20


<210>  19582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19582
aggaaaauga caauugaaca                                                   20


<210>  19583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19583
agaccagccu ggccaacgug                                                   20


<210>  19584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19584
acacguuggc caggcugguc                                                   20


<210>  19585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19585
ccugucucag ccucccgagu                                                   20


<210>  19586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19586
agcgauucuc cugucucagc                                                   20


<210>  19587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19587
guuuacaaac acaaauggag                                                   20


<210>  19588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19588
aaaguauugg gaauuuaacu                                                   20


<210>  19589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19589
caauacuuug gaaucauggc                                                   20


<210>  19590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19590
ucccauccua ggcaguuaaa                                                   20


<210>  19591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19591
aaaggcacuu aauucucugc                                                   20


<210>  19592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19592
cugcauucua agcuauauuu                                                   20


<210>  19593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19593
aagcuauauu ucaacaagca                                                   20


<210>  19594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19594
acaagcaaaa cuuccaaaca                                                   20


<210>  19595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19595
aaacagaauc ccaaaagaug                                                   20


<210>  19596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19596
guuuggaagu uuugcuuguu                                                   20


<210>  19597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19597
uggccugggg cugucuuggu                                                   20


<210>  19598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19598
ggggcuguuu gggggcauug                                                   20


<210>  19599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19599
aaacaagaua aaagaccuga                                                   20


<210>  19600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19600
uaaagauaau aaauccaauc                                                   20


<210>  19601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19601
acuccugacc aaguugggac                                                   20


<210>  19602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19602
cuggcguuuu ggaagucacc                                                   20


<210>  19603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19603
aaaacgccag ggaaguuuac                                                   20


<210>  19604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19604
ccugacuggc cugcaccucc                                                   20


<210>  19605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19605
cucucaccac agauugcuca                                                   20


<210>  19606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19606
gggaugccuc cugugccucu                                                   20


<210>  19607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19607
uaccuggcca cccugagcag                                                   20


<210>  19608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19608
cuuccaguga gaguccugua                                                   20


<210>  19609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19609
agugagaguc cuguagaauc                                                   20


<210>  19610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19610
acaggacucu cacuggaaga                                                   20


<210>  19611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19611
aaggucacuc uuagauucua                                                   20


<210>  19612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19612
caucuguagc aggagccaac                                                   20


<210>  19613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19613
cugggucuua guuuucucau                                                   20


<210>  19614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19614
cuucucuggg ucuuaguuuu                                                   20


<210>  19615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19615
ucucuucucu gggucuuagu                                                   20


<210>  19616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19616
cguucuucuc uucucugggu                                                   20


<210>  19617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19617
guucacguuc uucucuucuc                                                   20


<210>  19618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19618
ggaccaagac ucccgggcuc                                                   20


<210>  19619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19619
ggccacaugg cugcugggca                                                   20


<210>  19620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19620
aggccuggac ccaacacagc                                                   20


<210>  19621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19621
ucgcugccag cgcuccugcc                                                   20


<210>  19622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19622
auccucucaa agucagaguc                                                   20


<210>  19623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19623
ucaggaacca ucaaggugag                                                   20


<210>  19624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19624
ggaaccauca aggugagaug                                                   20


<210>  19625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19625
ugaagaaagg acucugacuu                                                   20


<210>  19626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19626
cagauuaucu gggagggguc                                                   20


<210>  19627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19627
guaggccguu guuuuauuau                                                   20


<210>  19628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19628
uucaguaggc cguuguuuua                                                   20


<210>  19629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19629
ggucaggaua gcuaagcucu                                                   20


<210>  19630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19630
gaugcccucu uuugagguug                                                   20


<210>  19631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19631
gaggggaagg caggggagcu                                                   20


<210>  19632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19632
ccuccgaauu cagaugcccu                                                   20


<210>  19633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19633
ucagugccau cagcuauugc                                                   20


<210>  19634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19634
gcuugcaaua gcugauggca                                                   20


<210>  19635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19635
acaugauugc auucagcuug                                                   20


<210>  19636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19636
aagaaacggu cuggccugaa                                                   20


<210>  19637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19637
uggaagggca gggugugagu                                                   20


<210>  19638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19638
ggccagaccg uuucuuggaa                                                   20


<210>  19639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19639
auggaggggg gaggggugau                                                   20


<210>  19640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19640
cacacucacc ccacaacauc                                                   20


<210>  19641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19641
ggucaugccc augccugggu                                                   20


<210>  19642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19642
aucuuguccu uucuggucau                                                   20


<210>  19643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19643
cuugggguuu ucaaucuugu                                                   20


<210>  19644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19644
gcagacuucc cuugggguuu                                                   20


<210>  19645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19645
aaccgguucu guggccucca                                                   20


<210>  19646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19646
guggccucca acaaaccccc                                                   20


<210>  19647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19647
cugagaaauu agggcaauag                                                   20


<210>  19648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19648
cagagaagua aacugaggcu                                                   20


<210>  19649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19649
cauuuugucu cuaugccacc                                                   20


<210>  19650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19650
aacuuaaaag uauuugucaa                                                   20


<210>  19651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19651
uugcccucca cccagauauu                                                   20


<210>  19652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19652
gaguaaauau cuggguggag                                                   20


<210>  19653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19653
gagaauuccc caaauuuacc                                                   20


<210>  19654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19654
cugaaaauuc ugaguaaaua                                                   20


<210>  19655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19655
ccaaauuuac caagcaccuu                                                   20


<210>  19656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19656
aaggugcuug guaaauuugg                                                   20


<210>  19657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19657
uccaaggugc uugguaaauu                                                   20


<210>  19658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19658
cuugcugcuc aaauucccuu                                                   20


<210>  19659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19659
cuuguaguua aucccagcuu                                                   20


<210>  19660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19660
uuaauaagau uaaaggggaa                                                   20


<210>  19661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19661
ccuuuaaucu uauuaaggaa                                                   20


<210>  19662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19662
accaggucau cucucaggac                                                   20


<210>  19663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19663
ugaguccuga gagaugaccu                                                   20


<210>  19664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19664
agucaucugc cucugucacc                                                   20


<210>  19665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19665
gcacugauuu gcucucaggu                                                   20


<210>  19666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19666
gaauguaauu ucauuucuga                                                   20


<210>  19667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19667
gaaaccagug cagaggagcc                                                   20


<210>  19668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19668
uuucugaagu cccuuuacuu                                                   20


<210>  19669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19669
gaagucccuu uacuuuugag                                                   20


<210>  19670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19670
gaaaugaaau uacauucuga                                                   20


<210>  19671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19671
ugagcuucug guucuaaagc                                                   20


<210>  19672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19672
gguucuaaag ccugaugaca                                                   20


<210>  19673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19673
aaagccugau gacacuuuag                                                   20


<210>  19674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19674
caccuguacu ccuacaguuu                                                   20


<210>  19675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19675
aggccagccu gggcaacaua                                                   20


<210>  19676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19676
agccugggug acagagcaag                                                   20


<210>  19677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19677
caccuugcau uccagccuuu                                                   20


<210>  19678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19678
agccuuuuuc aucuaaggac                                                   20


<210>  19679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19679
ucuaaggacu uuaaccuucg                                                   20


<210>  19680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19680
ggaccgaaca gagaaaucua                                                   20


<210>  19681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19681
gucccgaagg uuaaaguccu                                                   20


<210>  19682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19682
cuguucgguc ccgaagguua                                                   20


<210>  19683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19683
cuuuaagcaa caagauagug                                                   20


<210>  19684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19684
gaaaaaacaa ggaaugacca                                                   20


<210>  19685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19685
gaauggacuc cucucuuuuu                                                   20


<210>  19686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19686
uuguuuuuuc agaauggacu                                                   20


<210>  19687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19687
ugucucugcc agccuuaguc                                                   20


<210>  19688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19688
gcucaagcaa guagcuaaga                                                   20


<210>  19689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19689
aacuuggacu uggagccagg                                                   20


<210>  19690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19690
auguuuccua acaggcagua                                                   20


<210>  19691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19691
uaacaggcag uauggacaac                                                   20


<210>  19692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19692
uguuguccau acugccuguu                                                   20


<210>  19693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19693
aaaaguuuca uguuguccau                                                   20


<210>  19694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19694
caacaaaggu aaaaugcucc                                                   20


<210>  19695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19695
ucuacuuccg aaaggcuuaa                                                   20


<210>  19696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19696
acuuccgaaa ggcuuaaaaa                                                   20


<210>  19697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19697
gaaaggcuua aaaauuauuc                                                   20


<210>  19698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19698
gaaguagaag aaauaggggc                                                   20


<210>  19699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19699
aaagugagaa uauaauuaga                                                   20


<210>  19700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19700
cacuuuugaa uaauuuuuaa                                                   20


<210>  19701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19701
ucuaauuaua uucucacuuu                                                   20


<210>  19702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19702
gugguugcug cuuccucuaa                                                   20


<210>  19703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19703
caaucuccuc cucaaaagaa                                                   20


<210>  19704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19704
uuugaggagg agauugggaa                                                   20


<210>  19705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19705
acuaaaguaa auagcucuaa                                                   20


<210>  19706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19706
ucaagaaagc acucauauca                                                   20


<210>  19707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19707
ugaugaacug cgcccuuaga                                                   20


<210>  19708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19708
uagucauuua ucccacucug                                                   20


<210>  19709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19709
aauuuauuua uguguuuuau                                                   20


<210>  19710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19710
cccacccuag ggauaugauc                                                   20


<210>  19711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19711
uuuacugcau ggcagcagcc                                                   20


<210>  19712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19712
cuggcugaua cugggacagu                                                   20


<210>  19713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19713
cugcaggagu cucaggcccc                                                   20


<210>  19714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19714
cuggggccug agacuccugc                                                   20


<210>  19715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19715
cagcacuaag guaugcgacc                                                   20


<210>  19716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19716
uuuucaugau guacuguugu                                                   20


<210>  19717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19717
ugauguacug uugugucuuc                                                   20


<210>  19718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19718
acaccagccc cuguccuuua                                                   20


<210>  19719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19719
uccuuugccu ccuuuuuugc                                                   20


<210>  19720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19720
uuugccuccu uuuuugcuuu                                                   20


<210>  19721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19721
guuguuguuu ucuauuuggg                                                   20


<210>  19722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19722
auuuggguuu guuugcuucc                                                   20


<210>  19723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19723
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  19724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19724
ugagacagag ucucacucuu                                                   20


<210>  19725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19725
agcgauucuc gugccucagc                                                   20


<210>  19726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19726
cgugccucag ccucccaagu                                                   20


<210>  19727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19727
guagagauag gguuucacca                                                   20


<210>  19728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19728
ccauguuggc caggcugguc                                                   20


<210>  19729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19729
agaccagccu ggccaacaug                                                   20


<210>  19730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19730
uuuaacaguc uguuuuaauu                                                   20


<210>  19731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19731
guggcauuaa guacguucac                                                   20


<210>  19732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19732
caaugcugug uccucauccc                                                   20


<210>  19733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19733
ucauccccag cauaaauucc                                                   20


<210>  19734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19734
cuacccguua aacaguagcu                                                   20


<210>  19735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19735
ccauccccuc auuaaucccu                                                   20


<210>  19736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19736
auuuucuguc ucuaugaauu                                                   20


<210>  19737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19737
gucucuauga auuuacccag                                                   20


<210>  19738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19738
uagagacaga aaauggaaua                                                   20


<210>  19739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19739
augagguacc uauacugggu                                                   20


<210>  19740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19740
acuuccauga gguaccuaua                                                   20


<210>  19741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19741
uuuauuuuua uggcugaaua                                                   20


<210>  19742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19742
gccauaaaaa uaaaugaaau                                                   20


<210>  19743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19743
acugugugua uagcucacau                                                   20


<210>  19744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19744
ucucuucuuu ucuuuuuuuu                                                   20


<210>  19745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19745
uuucuuuuuu uuuuuuuuuu                                                   20


<210>  19746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19746
uuuuuuuuuu uuuuuuuccu                                                   20


<210>  19747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19747
ugagacagau uuucccucug                                                   20


<210>  19748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19748
cucugucacc caggcuggag                                                   20


<210>  19749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19749
cgugccucag ccuccugagu                                                   20


<210>  19750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19750
agcuacucag gaggcugagg                                                   20


<210>  19751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19751
ccauguuggc caggcugguc                                                   20


<210>  19752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19752
agaccagccu ggccaacaug                                                   20


<210>  19753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19753
ggaggccgag gcgggcagau                                                   20


<210>  19754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19754
ucuuuuuaug gaugcuuggg                                                   20


<210>  19755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19755
acuuugcguu uauugugacu                                                   20


<210>  19756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19756
uagcaguauu agucacaaua                                                   20


<210>  19757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19757
auacacucac guucauagca                                                   20


<210>  19758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19758
auucuuuugg cuauacaccu                                                   20


<210>  19759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19759
uuuggcuaua caccugggag                                                   20


<210>  19760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19760
acucccaggu guauagccaa                                                   20


<210>  19761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19761
ggaucguaug guaagugugc                                                   20


<210>  19762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19762
caaaaaguug cacacuuacc                                                   20


<210>  19763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19763
acagugauuc caccauuuga                                                   20


<210>  19764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19764
accauuugac auucccacca                                                   20


<210>  19765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19765
caccagcaau gcaugcgguc                                                   20


<210>  19766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19766
cuacauucua acuaacacuu                                                   20


<210>  19767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19767
aacuaacacu uguuauuuuc                                                   20


<210>  19768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19768
guuuuuguuu guuuguuuuu                                                   20


<210>  19769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19769
aguaggcaug aagugguguu                                                   20


<210>  19770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19770
ugccuacuag aauggcuauu                                                   20


<210>  19771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19771
uccaccucca ucaaaaaaag                                                   20


<210>  19772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19772
acccuauucc uccaccucca                                                   20


<210>  19773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19773
cagaggucua aggcccccag                                                   20


<210>  19774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19774
guaugaggua gcagccuccu                                                   20


<210>  19775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19775
uaaguuuguc accggagagg                                                   20


<210>  19776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19776
gugcccucuc cggugacaaa                                                   20


<210>  19777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19777
cuccaagaca auaaguuggu                                                   20


<210>  19778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19778
ucccuccaag acaauaaguu                                                   20


<210>  19779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19779
gccuugcugc uucuucccuc                                                   20


<210>  19780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19780
agucuucugc cuugcugcuu                                                   20


<210>  19781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19781
cagagaaaaa aacagucuac                                                   20


<210>  19782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19782
cugagaaguu caagucuucu                                                   20


<210>  19783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19783
uuuuaugcug uccucacaca                                                   20


<210>  19784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19784
guagugugug aggacagcau                                                   20


<210>  19785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19785
aacuagcugu guuaucucag                                                   20


<210>  19786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19786
cugauugaga gacugagacu                                                   20


<210>  19787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19787
cucguuggau gcucauugca                                                   20


<210>  19788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19788
agcugcuacu gccugcauuu                                                   20


<210>  19789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19789
ucuagcugcu acugccugca                                                   20


<210>  19790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19790
caaccauuuu cuucuagcug                                                   20


<210>  19791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19791
gauucccaac cauuuucuuc                                                   20


<210>  19792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19792
uuucagauuc ccaaccauuu                                                   20


<210>  19793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19793
uggggggcuu uaauucuuuu                                                   20


<210>  19794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19794
ucucacgccu ccuccaaaag                                                   20


<210>  19795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19795
cacgccuccu ccaaaagcca                                                   20


<210>  19796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19796
ccccgccucc aggacugcug                                                   20


<210>  19797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19797
ggcagcugcu gacagaaugu                                                   20


<210>  19798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19798
gucagcagcu gccggaaaug                                                   20


<210>  19799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19799
gaucccccgu ggcacaguca                                                   20


<210>  19800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19800
aaggaagcac uuggagggau                                                   20


<210>  19801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19801
uuugaagggu gagcccuggg                                                   20


<210>  19802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19802
caaaggucac acaggaaacu                                                   20


<210>  19803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19803
ugugugaccu uugagaagcc                                                   20


<210>  19804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19804
guuuccugug ugaccuuuga                                                   20


<210>  19805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19805
ccuauaguuu agauccaggc                                                   20


<210>  19806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19806
aaugcuccua uuucuccuau                                                   20


<210>  19807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19807
aaugugugga uucaaaugcu                                                   20


<210>  19808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19808
gcccaucuga gagcguuuag                                                   20


<210>  19809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19809
aauuaacauc aucagaucau                                                   20


<210>  19810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19810
aaacgcuuga gaaaaauguc                                                   20


<210>  19811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19811
caagcguuuu gaaguucaaa                                                   20


<210>  19812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19812
auuuuuaaaa agcaaagugg                                                   20


<210>  19813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19813
uuccauuuuu aaaaagcaaa                                                   20


<210>  19814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19814
agugacaaca caauaaggaa                                                   20


<210>  19815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19815
uuauuguguu gucacuagaa                                                   20


<210>  19816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19816
ucuccuagga uggauuuuau                                                   20


<210>  19817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19817
ucuuggcccu uccaaaggcc                                                   20


<210>  19818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19818
uggcccuucc aaaggccauu                                                   20


<210>  19819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19819
aaaggccauu uaccucuggg                                                   20


<210>  19820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19820
cucaucaccc aggaauuacg                                                   20


<210>  19821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19821
ugggugauga gugaacucug                                                   20


<210>  19822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19822
cuuguagcaa gcauaacccu                                                   20


<210>  19823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19823
uggcuucccu uguagcaagc                                                   20


<210>  19824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19824
aucugauccu gucuuacucu                                                   20


<210>  19825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19825
uacaaaggag guuggcucuu                                                   20


<210>  19826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19826
auaaagcuuu uugcuuuuuu                                                   20


<210>  19827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19827
ucaauaaagc uuuuugcuuu                                                   20


<210>  19828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19828
gucaggcagc ugcaaagacc                                                   20


<210>  19829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19829
uuucucacug ugacguaagc                                                   20


<210>  19830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19830
cacugugacg uaagcuaggc                                                   20


<210>  19831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19831
aaaugcacgc ucggcaccca                                                   20


<210>  19832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19832
gaucaguuuu aucugagucu                                                   20


<210>  19833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19833
cacacuuguu cagugcaccc                                                   20


<210>  19834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19834
gugcacccca gcaaaaccag                                                   20


<210>  19835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19835
gugucuucac uccuuguuga                                                   20


<210>  19836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19836
cuccuuguug agacuuggug                                                   20


<210>  19837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19837
uuaacccauu cacacuuaag                                                   20


<210>  19838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19838
cacuuaagug uuaccucaac                                                   20


<210>  19839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19839
cuccuaauug uguuauaaaa                                                   20


<210>  19840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19840
ucuuauuaag gaaauccaga                                                   20


<210>  19841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19841
uuaauaagau gaaaaucuuu                                                   20


<210>  19842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19842
uagacuaacu cugccccgcu                                                   20


<210>  19843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19843
ucauuaggug accuggggac                                                   20


<210>  19844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19844
cucuccuccc ugcugucccu                                                   20


<210>  19845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19845
cucuucagga gguggcuggu                                                   20


<210>  19846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19846
ggagguggcu gguggccuau                                                   20


<210>  19847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19847
ggagaggguu aggcaggggc                                                   20


<210>  19848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19848
uccgcagcca acaucaaggu                                                   20


<210>  19849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19849
ugcuugcgcc cuauugaccu                                                   20


<210>  19850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19850
ugcaauaauu uucccucuaa                                                   20


<210>  19851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19851
cucuaaucau aaagguuuaa                                                   20


<210>  19852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19852
aaaugccucc uuuuuagggg                                                   20


<210>  19853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19853
ucaaacccug caagcccuaa                                                   20


<210>  19854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19854
aacccugcaa gcccuaaaug                                                   20


<210>  19855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19855
ccauuuaggg cuugcagggu                                                   20


<210>  19856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19856
cacaaguuca ugugccuccc                                                   20


<210>  19857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19857
ugugccuccc uaaaacgcag                                                   20


<210>  19858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19858
ccuggcuuac agaugacgcu                                                   20


<210>  19859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19859
cccagaaccc ccaggugagg                                                   20


<210>  19860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19860
gggugaaggg agcuccccgc                                                   20


<210>  19861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19861
ucaccugggg guucugggug                                                   20


<210>  19862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19862
gagagggggc agagcugagg                                                   20


<210>  19863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19863
cucucagggu gucacugaga                                                   20


<210>  19864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19864
cugacucaag gguggcagga                                                   20


<210>  19865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19865
ugccacccuu gagucaguga                                                   20


<210>  19866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19866
ggguaauuag uggccuuccu                                                   20


<210>  19867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19867
cuggguggca caaacagccu                                                   20


<210>  19868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19868
ucuuucccug gguggcacaa                                                   20


<210>  19869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19869
cauggggaag ugcgucuucu                                                   20


<210>  19870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19870
ccaugagaaa aaggucaguu                                                   20


<210>  19871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19871
ccucuccaaa ccacaggcuc                                                   20


<210>  19872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19872
cuugagcugg ucugcuugug                                                   20


<210>  19873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19873
ugcaaugacc acugggugug                                                   20


<210>  19874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19874
ggccccugcu gagagggguc                                                   20


<210>  19875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19875
ccugcccugg uuuggaaccc                                                   20


<210>  19876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19876
aaaccagggc aggggaaugg                                                   20


<210>  19877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19877
uggcuuaggc ugggaggcac                                                   20


<210>  19878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19878
uuccuggcuu aggcugggag                                                   20


<210>  19879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19879
gauauauucc cacaagcaaa                                                   20


<210>  19880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19880
cacaagcaaa auuaaauacc                                                   20


<210>  19881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19881
cuaaaacaca uguuacuggu                                                   20


<210>  19882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19882
cccucaugag uucaauauaa                                                   20


<210>  19883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19883
auauaagucc augaacuaau                                                   20


<210>  19884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19884
uggacuuaua uugaacucau                                                   20


<210>  19885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19885
ucuguguuaa cauuaacacc                                                   20


<210>  19886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19886
guguuaacau uaacacccuu                                                   20


<210>  19887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19887
cucauaaggg uguuaauguu                                                   20


<210>  19888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19888
guacacuuug gggaguaaaa                                                   20


<210>  19889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19889
cuggaggaug uggcgggaua                                                   20


<210>  19890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19890
cuuaugagca accacagcua                                                   20


<210>  19891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19891
caguggcaga cuggauuaca                                                   20


<210>  19892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19892
ucgcaguggc agacuggauu                                                   20


<210>  19893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19893
ccucuuugca cugagacaua                                                   20


<210>  19894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19894
uucucuuaca uuuagauuaa                                                   20


<210>  19895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19895
cuuacauuua gauuaauuau                                                   20


<210>  19896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19896
ggugacaaug uuuuauaauu                                                   20


<210>  19897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19897
guguauuaaa cauuacuuua                                                   20


<210>  19898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19898
cuucugugua uuaaacauua                                                   20


<210>  19899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19899
agaguaccuu auucccuucu                                                   20


<210>  19900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19900
cuaugaugau uuugccaguu                                                   20


<210>  19901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19901
auagcuggca aucaaaagau                                                   20


<210>  19902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19902
cuagcuuuuu auuuuugcaa                                                   20


<210>  19903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19903
aagugcuaug acaggauggu                                                   20


<210>  19904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19904
gucagcuugg uuccaaagaa                                                   20


<210>  19905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19905
aaagaaggga gaugauagga                                                   20


<210>  19906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19906
uuggaaccaa gcugacagaa                                                   20


<210>  19907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19907
acuucagcaa gccuaacaca                                                   20


<210>  19908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19908
gcaagccuaa cacagcuggg                                                   20


<210>  19909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19909
ccaccaccca gcuguguuag                                                   20


<210>  19910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19910
aaggacgugu gugugugugu                                                   20


<210>  19911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19911
cauguucaaa ggacgugugu                                                   20


<210>  19912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19912
uaaauggaaa ucucaagucc                                                   20


<210>  19913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19913
auuuaggaau guugacaccu                                                   20


<210>  19914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19914
gauuuuccaa gcucuacugc                                                   20


<210>  19915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19915
aagcucuacu gcagccauac                                                   20


<210>  19916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19916
uccggggugu auggcugcag                                                   20


<210>  19917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19917
gaugauuccu ccggggugua                                                   20


<210>  19918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19918
gcuagcugug acucgguguu                                                   20


<210>  19919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19919
gccacugcca gcaaggagag                                                   20


<210>  19920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19920
ucagggggcu gcuccugggg                                                   20


<210>  19921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19921
aggucucucu ccaggucucc                                                   20


<210>  19922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19922
ccuguggaga ccuggagaga                                                   20


<210>  19923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19923
acgaugauaa ucauuuaaaa                                                   20


<210>  19924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19924
gcuauuacug ugauuauuuu                                                   20


<210>  19925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19925
cagcacacuc acugggcaag                                                   20


<210>  19926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19926
gucacaccac caagaaugcu                                                   20


<210>  19927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19927
ugguggugug acagaagcau                                                   20


<210>  19928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19928
accagcauuc uugguggugu                                                   20


<210>  19929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19929
caguguguuu uaaaacuaaa                                                   20


<210>  19930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19930
guuuauccau gcccccuaau                                                   20


<210>  19931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19931
auucucuuca aggccuccua                                                   20


<210>  19932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19932
cuucaaggcc uccuacgucu                                                   20


<210>  19933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19933
aggccuccua cgucucucug                                                   20


<210>  19934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19934
aaaauauacu ggaugugaaa                                                   20


<210>  19935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19935
aagagcagag gguagagguc                                                   20


<210>  19936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19936
cauccaguau auuuucgaag                                                   20


<210>  19937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19937
auuugcaaca cggaggcccc                                                   20


<210>  19938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19938
gacccaaggg gccuccgugu                                                   20


<210>  19939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19939
augugauuuc caguaggaga                                                   20


<210>  19940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19940
aguaggagag gggauagguu                                                   20


<210>  19941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19941
auagacacaa ggacccccua                                                   20


<210>  19942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19942
agccuuuacc uuuaacucca                                                   20


<210>  19943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19943
ccuggaguua aagguaaagg                                                   20


<210>  19944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19944
cucugggcuc ccacucuucu                                                   20


<210>  19945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19945
gaggauaaga cuacagaaac                                                   20


<210>  19946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19946
guagucuuau ccucagaagc                                                   20


<210>  19947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19947
ugugccaccc guauacacac                                                   20


<210>  19948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19948
uuguguauau aucuauuuau                                                   20


<210>  19949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19949
cauacauaua ccaugauucu                                                   20


<210>  19950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19950
gacucauggg caaaauggaa                                                   20


<210>  19951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19951
auuuugccca ugagucagaa                                                   20


<210>  19952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19952
uuuccauuuu gcccaugagu                                                   20


<210>  19953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19953
uucuuuucca uuuugcccau                                                   20


<210>  19954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19954
aagggccugu uugcauagau                                                   20


<210>  19955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19955
uaacccaagu auaguaugua                                                   20


<210>  19956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19956
ugucagcaca aggcuuaauc                                                   20


<210>  19957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19957
cuagcuaagc acccccucuu                                                   20


<210>  19958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19958
uucacuagcu aagcaccccc                                                   20


<210>  19959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19959
ucucacacag gccuugcuuu                                                   20


<210>  19960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19960
ucccuguccc cacucaaggu                                                   20


<210>  19961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19961
uuacacuuua cuauauuuca                                                   20


<210>  19962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19962
gugggagggg aaauaugggg                                                   20


<210>  19963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19963
ccucccacug aaauauagua                                                   20


<210>  19964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19964
caccucaggg gaacacuucc                                                   20


<210>  19965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19965
ccugaggugu gaaaacacuc                                                   20


<210>  19966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19966
auguguguug aaccccucag                                                   20


<210>  19967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19967
acacacaugg aaguguuccc                                                   20


<210>  19968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19968
cuugugacug auccuuagca                                                   20


<210>  19969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19969
cccagagcuc uguggucucc                                                   20


<210>  19970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19970
uccuagaguu ucucccagag                                                   20


<210>  19971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19971
uuuuuggugc uggauugcaa                                                   20


<210>  19972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19972
uuauaugccc uaaauauuau                                                   20


<210>  19973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19973
aggagaaaca ggauaguagg                                                   20


<210>  19974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19974
ccuggaagca ggacuagucu                                                   20


<210>  19975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19975
cuaucucucu cccccaugcc                                                   20


<210>  19976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19976
aaaauagaga cuugguauuu                                                   20


<210>  19977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19977
cucucuugga gcuugcauuu                                                   20


<210>  19978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19978
cugcacaaag uaaggcagug                                                   20


<210>  19979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19979
uugguuaugu auauacaugc                                                   20


<210>  19980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19980
aauccaugcc uuuauuacga                                                   20


<210>  19981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19981
uaauaaaggc auggauuaga                                                   20


<210>  19982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19982
ucuaauguug uggccaaaug                                                   20


<210>  19983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19983
uugcaauaug cuuguuggua                                                   20


<210>  19984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19984
ccuauuugua aaaguuacau                                                   20


<210>  19985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19985
uaaaucacag cuggguggug                                                   20


<210>  19986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19986
aaugauccuc cugccuuggc                                                   20


<210>  19987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19987
uuuuguagac acagggucuu                                                   20


<210>  19988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19988
uaaaucuccc cucaaaaaag                                                   20


<210>  19989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19989
uuuuugaggg gagauuuaag                                                   20


<210>  19990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19990
auucuuuuuu cuguuagguu                                                   20


<210>  19991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19991
uuuuucuguu agguuuauca                                                   20


<210>  19992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19992
guuagguuua ucauuuugcu                                                   20


<210>  19993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19993
ugucucauua agcacuuaac                                                   20


<210>  19994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19994
uagggauuga cuauuuuuac                                                   20


<210>  19995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19995
uuauggguug auccuacacc                                                   20


<210>  19996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19996
uccuuauggg uugauccuac                                                   20


<210>  19997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19997
agcuucuaca gucuuugaug                                                   20


<210>  19998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19998
acagucuuug augggucuag                                                   20


<210>  19999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  19999
ccauuugugc uggucuagac                                                   20


<210>  20000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20000
aacaacaggg ucaaugucua                                                   20


<210>  20001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20001
aauagacauu gacccuguug                                                   20


<210>  20002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20002
gcugugcaua caguacuugg                                                   20


<210>  20003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20003
augaaacaac cagugccuuc                                                   20


<210>  20004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20004
uugaaggauu cugcugugca                                                   20


<210>  20005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20005
aggaucggcc uucuacuggu                                                   20


<210>  20006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20006
acuggucucu uggcuuguuu                                                   20


<210>  20007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20007
aaacaagcca agagaccagu                                                   20


<210>  20008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20008
cuuucaaucu auuucaugcc                                                   20


<210>  20009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20009
aucuauuuca ugcccugcua                                                   20


<210>  20010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20010
ugcccugcua cacucuucca                                                   20


<210>  20011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20011
aaaacuuuuc uauggacaug                                                   20


<210>  20012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20012
auggacauga uuuugaauaa                                                   20


<210>  20013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20013
aaaucauguc cauagaaaag                                                   20


<210>  20014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20014
uaaaucuuau agucaguuaa                                                   20


<210>  20015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20015
agaccagccu ggccaacaug                                                   20


<210>  20016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20016
ucauguuggc caggcugguc                                                   20


<210>  20017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20017
agcuacucgg gaggcugagg                                                   20


<210>  20018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20018
ccugccucag ccucccgagu                                                   20


<210>  20019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20019
agcaauucuc cugccucagc                                                   20


<210>  20020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20020
cucuuguugc ccaagcuaga                                                   20


<210>  20021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20021
uaaaucuuuu uuuuuuuuuu                                                   20


<210>  20022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20022
ccauaacaug gccccaaauu                                                   20


<210>  20023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20023
caccuuaugu uccacuaguu                                                   20


<210>  20024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20024
acuaguuuca uagacaaacc                                                   20


<210>  20025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20025
uagacaaacc ucuuccugcc                                                   20


<210>  20026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20026
ugccauacug gucuggucag                                                   20


<210>  20027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20027
aggcaguacu gcagugucug                                                   20


<210>  20028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20028
cucugucauc uaaauucuag                                                   20


<210>  20029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20029
agccugucuu ugauggcuaa                                                   20


<210>  20030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20030
cugaggccca cagagauguu                                                   20


<210>  20031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20031
ucugcauucc uccaguuggc                                                   20


<210>  20032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20032
uccaguuggc aucucucacu                                                   20


<210>  20033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20033
ccacgugccu agagccucuu                                                   20


<210>  20034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20034
cccagccuac agugugcaag                                                   20


<210>  20035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20035
cagaucauca gcauaagcaa                                                   20


<210>  20036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20036
ccuguuugca guauuaucuu                                                   20


<210>  20037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20037
uugucuuguu ccauuuggaa                                                   20


<210>  20038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20038
auuuggaaug aauuaguggc                                                   20


<210>  20039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20039
aaauggaaca agacaaagaa                                                   20


<210>  20040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20040
uuccaaaugg aacaagacaa                                                   20


<210>  20041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20041
gaagguuaaa auacguggac                                                   20


<210>  20042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20042
gaacugaccu cuaacugauu                                                   20


<210>  20043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20043
uguuacuaac cucuuucuaa                                                   20


<210>  20044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20044
aaaucauugg uguuguuauu                                                   20


<210>  20045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20045
uguaaauaac aacaccaaug                                                   20


<210>  20046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20046
ucacauauuu ggcccagucc                                                   20


<210>  20047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20047
aaugguaggg augaguauac                                                   20


<210>  20048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20048
ucagugguac acacacuuaa                                                   20


<210>  20049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20049
uacuucauca gugguacaca                                                   20


<210>  20050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20050
ucauacuuca ucagugguac                                                   20


<210>  20051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20051
cauucauucc agaguacuca                                                   20


<210>  20052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20052
uuccagagua cucaggcccu                                                   20


<210>  20053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20053
agaguacuca ggcccuuugc                                                   20


<210>  20054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20054
cuuugcaugu guagcuagca                                                   20


<210>  20055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20055
auaucagcau uuuguaaagc                                                   20


<210>  20056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20056
caccguacca gcuuaacugc                                                   20


<210>  20057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20057
aauuaauuua auucuccacu                                                   20


<210>  20058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20058
ccacugguag caauuucuga                                                   20


<210>  20059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20059
gaugcacaau gucugugccu                                                   20


<210>  20060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20060
ccagcacuua acucagcagg                                                   20


<210>  20061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20061
ugcuauaugc aaccugcuga                                                   20


<210>  20062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20062
aucaacaaau auuuauuagg                                                   20


<210>  20063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20063
uuuguucaau caacaaauau                                                   20


<210>  20064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20064
ccaucugccg uauggcucau                                                   20


<210>  20065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20065
cucuccagua uucuccaucu                                                   20


<210>  20066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20066
ucagauaugc cucacaaaac                                                   20


<210>  20067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20067
gaugcuggga ggaccgguau                                                   20


<210>  20068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20068
guccauuucu gaugcuggga                                                   20


<210>  20069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20069
ugcuguggua cuugcauuuc                                                   20


<210>  20070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20070
gcagacuaug gagcaaggcu                                                   20


<210>  20071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20071
aagugguuuu gcuuugaggg                                                   20


<210>  20072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20072
uaaucaguuu aauuagcacu                                                   20


<210>  20073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20073
uaccacuugu aaugccaaug                                                   20


<210>  20074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20074
ggaugaggua gauacuagga                                                   20


<210>  20075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20075
guaguuauau gacaguagua                                                   20


<210>  20076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20076
acuuaagcuu agagagacuu                                                   20


<210>  20077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20077
uucuacuuaa gcuuagagag                                                   20


<210>  20078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20078
ugaucaucgu gugguauagg                                                   20


<210>  20079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20079
uccugaucau cgugugguau                                                   20


<210>  20080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20080
ucuuccugau caucgugugg                                                   20


<210>  20081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20081
uauuucuucu uccugaucau                                                   20


<210>  20082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20082
agaccagucu aaucaacaua                                                   20


<210>  20083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20083
cuauguugau uagacugguc                                                   20


<210>  20084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20084
ccuaccucag ccuccagagu                                                   20


<210>  20085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20085
agcaauucuc cuaccucagc                                                   20


<210>  20086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20086
uuuuuuuuuu uuugagaugg                                                   20


<210>  20087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20087
aagcauguuc uuuuuuuuuu                                                   20


<210>  20088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20088
aggcacagug auaaggauuu                                                   20


<210>  20089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20089
caauaaacau uagcugauau                                                   20


<210>  20090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20090
acuuuaaccu acguuuuccu                                                   20


<210>  20091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20091
ucuuuaccaa gcucugggca                                                   20


<210>  20092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20092
cguccuugau uggcagacug                                                   20


<210>  20093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20093
cagucagaga ucacauuuca                                                   20


<210>  20094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20094
gaaacaucug ggccuggauc                                                   20


<210>  20095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20095
gaaaugugau cucugacuga                                                   20


<210>  20096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20096
ggugccugga gauccaggcc                                                   20


<210>  20097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20097
ucgggugccu ggagauccag                                                   20


<210>  20098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20098
cacagggccu cggcaucuca                                                   20


<210>  20099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20099
ugcuggaggg uagcauggag                                                   20


<210>  20100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20100
ccccuuuucc ugcuggaggg                                                   20


<210>  20101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20101
aacaaaaauc gcuugcugcu                                                   20


<210>  20102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20102
aaaaccaaag cugucgucau                                                   20


<210>  20103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20103
gugacauaag cuuauaaaga                                                   20


<210>  20104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20104
uuauaagcuu augucacaga                                                   20


<210>  20105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20105
uugcuuuugg cuaguaaacc                                                   20


<210>  20106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20106
ggccucuugg gacuggagug                                                   20


<210>  20107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20107
uguguuccgg ccucuuggga                                                   20


<210>  20108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20108
cagcagcacg caacagucac                                                   20


<210>  20109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20109
uaccuccuac uucccagcag                                                   20


<210>  20110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20110
uuuuucagag ggaggaaugg                                                   20


<210>  20111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20111
gagggaggaa ugggccuuga                                                   20


<210>  20112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20112
ucccucugaa aaaggaagga                                                   20


<210>  20113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20113
aggcccauuc cucccucuga                                                   20


<210>  20114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20114
gcaugugaca cauucaaggc                                                   20


<210>  20115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20115
cugagcccac agcucagggu                                                   20


<210>  20116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20116
ugugcuuuuu ggucuggacu                                                   20


<210>  20117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20117
cucugacaca ggccuaugug                                                   20


<210>  20118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20118
uuucccucug acacaggccu                                                   20


<210>  20119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20119
cugagagcac auuuucuuuu                                                   20


<210>  20120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20120
gcuucucuga gagcacauuu                                                   20


<210>  20121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20121
acaaauaagg cauauuggcu                                                   20


<210>  20122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20122
uuaaagcggu ccuuugugug                                                   20


<210>  20123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20123
ugaguucuga gcuuugggug                                                   20


<210>  20124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20124
gagcuuuggg ugaguuucug                                                   20


<210>  20125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20125
gaagaggaau auuugcauuu                                                   20


<210>  20126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20126
gaaacucacc caaagcucag                                                   20


<210>  20127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20127
ucuucagaaa cucacccaaa                                                   20


<210>  20128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20128
ccuuugugug gugaagcaac                                                   20


<210>  20129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20129
ccacacaaag gggaaaaacc                                                   20


<210>  20130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20130
gagugacuga uuuuaccugu                                                   20


<210>  20131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20131
auuucagagu gacugauuuu                                                   20


<210>  20132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20132
uuugggcucu aagauuugca                                                   20


<210>  20133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20133
uaccucucaa uuggcuuucu                                                   20


<210>  20134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20134
acguauucua gaagagggac                                                   20


<210>  20135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20135
agaagaggga caaaucagca                                                   20


<210>  20136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20136
agaauacgua gaaagccaau                                                   20


<210>  20137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20137
cucucccugc ugauuugucc                                                   20


<210>  20138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20138
gcuucucucu cccugcugau                                                   20


<210>  20139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20139
gaaauggcag cgggaguugu                                                   20


<210>  20140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20140
gaaccuucug cuucucucuc                                                   20


<210>  20141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20141
uuagauggua augcaagcag                                                   20


<210>  20142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20142
ggcaacuauc acugggggaa                                                   20


<210>  20143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20143
cccagugaua guugccugaa                                                   20


<210>  20144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20144
ucucagacca uccucaacag                                                   20


<210>  20145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20145
cgcugucuuu cuccuauuuc                                                   20


<210>  20146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20146
ccuauuucag ggagggcuuu                                                   20


<210>  20147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20147
gggagggcuu ugccugugca                                                   20


<210>  20148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20148
aagucaaccc auguccacua                                                   20


<210>  20149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20149
aguggacaug gguugacuuu                                                   20


<210>  20150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20150
cauuuauuuc uaguggacau                                                   20


<210>  20151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20151
ugccagucac ccuuugauuc                                                   20


<210>  20152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20152
uuucuugcca gucacccuuu                                                   20


<210>  20153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20153
cccaccuugg ccucccaaag                                                   20


<210>  20154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20154
ccauguuagc caggcugguc                                                   20


<210>  20155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20155
acuaaaaaua caaaaaauua                                                   20


<210>  20156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20156
agcuacucag gaggcugagg                                                   20


<210>  20157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20157
ccugccucag ccuccugagu                                                   20


<210>  20158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20158
agugauuccc cugccucagc                                                   20


<210>  20159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20159
uuuuuuuuuu ugagauggag                                                   20


<210>  20160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20160
uucuuuuuuu uuuuugagau                                                   20


<210>  20161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20161
cuaacaggau gugauguggc                                                   20


<210>  20162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20162
aauucagugg guguuucucu                                                   20


<210>  20163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20163
guggguguuu cucuuauauc                                                   20


<210>  20164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20164
cuuauaucuu gucuagagaa                                                   20


<210>  20165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20165
cuagacaaga uauaagagaa                                                   20


<210>  20166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20166
auucucuaga caagauauaa                                                   20


<210>  20167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20167
ucuccaauga cuuaaguggg                                                   20


<210>  20168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20168
uggucuccag guuuauuucu                                                   20


<210>  20169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20169
accguuggag gggugaauua                                                   20


<210>  20170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20170
ccccuccaac gguagaaaua                                                   20


<210>  20171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20171
uuaauucacc ccuccaacgg                                                   20


<210>  20172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20172
ucuuuaauuc accccuccaa                                                   20


<210>  20173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20173
gguugugacc uaaaucuucu                                                   20


<210>  20174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20174
ccgucauagg aauacuauuu                                                   20


<210>  20175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20175
uaugacggag aagauuuagg                                                   20


<210>  20176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20176
aaaauaguau uccuaugacg                                                   20


<210>  20177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20177
guauggggca ggcugacaug                                                   20


<210>  20178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20178
cugcuaguac uggcacuacc                                                   20


<210>  20179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20179
uaaauccuuc ugaaaugcau                                                   20


<210>  20180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20180
gaaaugcaua cuuuucugcu                                                   20


<210>  20181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20181
gaaggauuua agaacaaacc                                                   20


<210>  20182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20182
gcuauuccua uuucugaauu                                                   20


<210>  20183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20183
uauuucugaa uuuagugggu                                                   20


<210>  20184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20184
gaauuuagug ggucacuagg                                                   20


<210>  20185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20185
gaaauaggaa uagcagaaaa                                                   20


<210>  20186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20186
aguggcaaau cucucccuag                                                   20


<210>  20187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20187
uuugcacagg agcugggaga                                                   20


<210>  20188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20188
aauucugacu cagccacuaa                                                   20


<210>  20189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20189
gacucagcca cuaacugugu                                                   20


<210>  20190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20190
agcuuggcua ugauguuuuu                                                   20


<210>  20191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20191
cacugugauc uuagguacuu                                                   20


<210>  20192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20192
cuuaaucuuu gggcccuuau                                                   20


<210>  20193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20193
gaucucuaaa augagugauu                                                   20


<210>  20194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20194
uuucaacuuc agucuauucu                                                   20


<210>  20195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20195
acuucagucu auucuuuucu                                                   20


<210>  20196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20196
gucuauucuu uucuuaucua                                                   20


<210>  20197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20197
uuucuuaucu aauuuauaga                                                   20


<210>  20198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20198
uaucuaauuu auagaaucac                                                   20


<210>  20199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20199
auaaauuaga uaagaaaaga                                                   20


<210>  20200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20200
uugugauucu auaaauuaga                                                   20


<210>  20201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20201
aucauguaua uaaaaguauu                                                   20


<210>  20202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20202
auaaagcuua aguacuuccu                                                   20


<210>  20203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20203
ugggagcauu uuuuaaaaua                                                   20


<210>  20204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20204
uuuugcuuug uauuuuaaaa                                                   20


<210>  20205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20205
uaauaagaua uccuaauuua                                                   20


<210>  20206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20206
aucuuaguuu aaauuaggau                                                   20


<210>  20207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20207
ggauuuuacu ggaagugaga                                                   20


<210>  20208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20208
aguaaaaucc agaagcaguc                                                   20


<210>  20209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20209
cacuuccagu aaaauccaga                                                   20


<210>  20210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20210
augacuuaau guaacuccag                                                   20


<210>  20211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20211
ccuggaguua cauuaaguca                                                   20


<210>  20212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20212
guuugcauuc cccuggaguu                                                   20


<210>  20213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20213
ucugacugcc uaggagagac                                                   20


<210>  20214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20214
uuccucugac ugccuaggag                                                   20


<210>  20215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20215
cugcugguua ggaacucaag                                                   20


<210>  20216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20216
uaaccagcag agaaacaaua                                                   20


<210>  20217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20217
ucuugaguuc cuaaccagca                                                   20


<210>  20218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20218
agaguucauc uugaguuccu                                                   20


<210>  20219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20219
ucaagaguuc aucuugaguu                                                   20


<210>  20220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20220
uucuucaaga guucaucuug                                                   20


<210>  20221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20221
aaaauaacug gugaugcaag                                                   20


<210>  20222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20222
accagacuca aaauuccuca                                                   20


<210>  20223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20223
ucaaaucugc uuccuucaca                                                   20


<210>  20224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20224
uucacacuau acuccaaaag                                                   20


<210>  20225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20225
cacuauacuc caaaaggagu                                                   20


<210>  20226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20226
uacaguaugc cacauagcuu                                                   20


<210>  20227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20227
guucuuacag uaugccacau                                                   20


<210>  20228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20228
auucuaaucc uacuauuacu                                                   20


<210>  20229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20229
aauccuacua uuacuuccgg                                                   20


<210>  20230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20230
ggggacacug auuuauaaaa                                                   20


<210>  20231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20231
uauuuuauaa aucagugucc                                                   20


<210>  20232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20232
uauuuuauaa uucuuauuuu                                                   20


<210>  20233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20233
uauuuuuaaa aauucuuauu                                                   20


<210>  20234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20234
ucaauguuaa ccucacuauc                                                   20


<210>  20235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20235
gguuuuguau gcguugacau                                                   20


<210>  20236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20236
ugaccacuug aagggcuugg                                                   20


<210>  20237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20237
aguggucagg aauaucuuuc                                                   20


<210>  20238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20238
gauuaaaacc aagcccuuca                                                   20


<210>  20239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20239
aagagcauuc agauuaaaac                                                   20


<210>  20240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20240
gggcacuuuu gcuuggaguu                                                   20


<210>  20241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20241
aagauugcac uccuugccua                                                   20


<210>  20242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20242
uuaaaugauc acugguuuuu                                                   20


<210>  20243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20243
aaaaccagug aucauuuaaa                                                   20


<210>  20244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20244
caaacaggcu gauauucaac                                                   20


<210>  20245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20245
acaugcugga ugcugggugc                                                   20


<210>  20246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20246
cucccaucau ggaccccaau                                                   20


<210>  20247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20247
aacagaccuu uuuuauacag                                                   20


<210>  20248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20248
agaccagccu gaccaacaug                                                   20


<210>  20249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20249
ccauguuggu caggcugguc                                                   20


<210>  20250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20250
ccugccucag ccuccugagu                                                   20


<210>  20251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20251
agugguucuc cugccucagc                                                   20


<210>  20252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20252
gauuauuauu auuauuauua                                                   20


<210>  20253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20253
caagccuuuu gugggcuguu                                                   20


<210>  20254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20254
gauugcagag agauaaauug                                                   20


<210>  20255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20255
acucugcaga gaggacacag                                                   20


<210>  20256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20256
cacugugucc ucucugcaga                                                   20


<210>  20257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20257
cugcuucugc cauucaugga                                                   20


<210>  20258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20258
gccauucaug gauaaccaug                                                   20


<210>  20259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20259
uggauaacca ugaucuugac                                                   20


<210>  20260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20260
caaauuguca aucuuguaug                                                   20


<210>  20261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20261
aaagucuagc ccuaggccag                                                   20


<210>  20262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20262
ccguguuagc caggaugguc                                                   20


<210>  20263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20263
caaguagcug ggacuacagg                                                   20


<210>  20264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20264
agggauccuc cugccucagc                                                   20


<210>  20265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20265
gucuuaaaaa aaaaaaaaaa                                                   20


<210>  20266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20266
uaauaaauuc uguaaauaaa                                                   20


<210>  20267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20267
guaaauaaau uuuuguuguc                                                   20


<210>  20268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20268
acuuuaaaag ccaugggaaa                                                   20


<210>  20269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20269
cauggcuuuu aaaguugaaa                                                   20


<210>  20270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20270
guuuguuuug aggggguucu                                                   20


<210>  20271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20271
ucuccacagu gaagaggaua                                                   20


<210>  20272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20272
ccacagugaa gaggauaaaa                                                   20


<210>  20273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20273
cuguggagaa gaacccccuc                                                   20


<210>  20274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20274
guuauccucu ugccccuuaa                                                   20


<210>  20275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20275
cagagucagu uuguaaauaa                                                   20


<210>  20276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20276
ucucagaguc aguuuguaaa                                                   20


<210>  20277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20277
acccccacuu uuuauauauu                                                   20


<210>  20278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20278
ggucuguguu ucuaccccca                                                   20


<210>  20279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20279
uuucuggucu guguuucuac                                                   20


<210>  20280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20280
gccuuuguaa cugcacuugg                                                   20


<210>  20281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20281
guucuggccu cccuuuggaa                                                   20


<210>  20282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20282
ggccucccuu uggaaguggu                                                   20


<210>  20283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20283
aaagggaggc cagaacugaa                                                   20


<210>  20284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20284
aggcaucagc aaggaguuca                                                   20


<210>  20285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20285
gcacauuuag ggaggaagcc                                                   20


<210>  20286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20286
ucccuaaaug ugcugaacuc                                                   20


<210>  20287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20287
gugauggcuu ccucccuaaa                                                   20


<210>  20288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20288
gcaacacaua ggcagagcau                                                   20


<210>  20289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20289
uuaugaaaua acuucuuguc                                                   20


<210>  20290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20290
uaaagaaacc cucucccugc                                                   20


<210>  20291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20291
ugucuggaag ucccaacuaa                                                   20


<210>  20292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20292
agacaagaag uuauuucaua                                                   20


<210>  20293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20293
uaucaauuag uugggacuuc                                                   20


<210>  20294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20294
augacaaaua acccugauug                                                   20


<210>  20295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20295
ccuguggcuu uuccaugaca                                                   20


<210>  20296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20296
cagugcacac aucuguuggu                                                   20


<210>  20297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20297
uaccaacaga ugugugcacu                                                   20


<210>  20298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20298
cagacacaca cauguggcuu                                                   20


<210>  20299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20299
uguguuagca cauaagucau                                                   20


<210>  20300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20300
ccaaacucug uuuaacugau                                                   20


<210>  20301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20301
uguccagagc uaauuucacc                                                   20


<210>  20302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20302
gguuucuugu ccagagcuaa                                                   20


<210>  20303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20303
cugcuuucuc ucuuacugau                                                   20


<210>  20304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20304
cucuuacuga uguggccucu                                                   20


<210>  20305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20305
acuuuaugga gguggagauu                                                   20


<210>  20306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20306
ccugcucucu gggacagauc                                                   20


<210>  20307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20307
cuacuguaga cagucauuau                                                   20


<210>  20308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20308
uaauaaauaa ugacugucua                                                   20


<210>  20309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20309
ugcuuauuca uaauaaauaa                                                   20


<210>  20310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20310
caugccaauu auuuggcuau                                                   20


<210>  20311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20311
cuaagcuagg uaaucuagcc                                                   20


<210>  20312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20312
ggcuagauua ccuagcuuag                                                   20


<210>  20313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20313
ccacuuaggu ucacggccug                                                   20


<210>  20314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20314
cggccuguau gugaaucuac                                                   20


<210>  20315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20315
cauacaggcc gugaaccuaa                                                   20


<210>  20316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20316
aauucucuuc uggaucucca                                                   20


<210>  20317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20317
cuucuggauc uccaagcagu                                                   20


<210>  20318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20318
ggaucuccaa gcaguaaaaa                                                   20


<210>  20319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20319
caguuuggua uuuuuuacug                                                   20


<210>  20320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20320
gugcaaauua acugggccag                                                   20


<210>  20321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20321
ggcccaguua auuugcacag                                                   20


<210>  20322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20322
uucuggccca guuaauuugc                                                   20


<210>  20323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20323
aaggaauaga gcauugcugu                                                   20


<210>  20324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20324
uuagaaauua gugccacaaa                                                   20


<210>  20325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20325
gaugugaacu ucuuuccucc                                                   20


<210>  20326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20326
caucagaaca gacaaucaca                                                   20


<210>  20327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20327
uuccuccuau aauuuccccc                                                   20


<210>  20328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20328
uccuauaauu uccccccucu                                                   20


<210>  20329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20329
ccccucuaaa aucugcccca                                                   20


<210>  20330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20330
ugauguaagu acuaaagaag                                                   20


<210>  20331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20331
uuaguacuua caucaggaaa                                                   20


<210>  20332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20332
ugaagguuug ggaaccuaaa                                                   20


<210>  20333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20333
ggaaauauau cuuaaugcag                                                   20


<210>  20334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20334
caaaccuuca ggaaauauau                                                   20


<210>  20335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20335
aauuuuaggu ucccaaaccu                                                   20


<210>  20336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20336
uauuaaauau ucuaauuuua                                                   20


<210>  20337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20337
uuaggauuua ccgcucgccc                                                   20


<210>  20338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20338
uuccuaagcu aaauuaaaag                                                   20


<210>  20339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20339
uaagcuaaau uaaaagacaa                                                   20


<210>  20340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20340
aauccugcau gguagccacc                                                   20


<210>  20341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20341
aauauaugcu uuugguggcu                                                   20


<210>  20342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20342
gcgugccaua uuaugcauua                                                   20


<210>  20343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20343
uaacugucug acuuauaauu                                                   20


<210>  20344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20344
gcauuaauaa acagcaauau                                                   20


<210>  20345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20345
caaguuuugc auuuugauuc                                                   20


<210>  20346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20346
ccuugaaaau uuaugccauc                                                   20


<210>  20347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20347
aggagaauca aaaugcaaaa                                                   20


<210>  20348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20348
ccuccuacau cuccugccca                                                   20


<210>  20349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20349
caaaucuguu ccuccuaccc                                                   20


<210>  20350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20350
uccuacccac ccgaugggug                                                   20


<210>  20351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20351
uacagacacc caucgggugg                                                   20


<210>  20352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20352
guaccuguuu ccuacagaca                                                   20


<210>  20353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20353
uuaauuuuua augcuuauaa                                                   20


<210>  20354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20354
auguugucuu uuaaaaagug                                                   20


<210>  20355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20355
auacauucua uguugucuuu                                                   20


<210>  20356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20356
acaauacagg uaauuagguu                                                   20


<210>  20357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20357
gaagggccag ggcaucacuc                                                   20


<210>  20358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20358
gaaaccagcc aaccuaauua                                                   20


<210>  20359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20359
cuguuccaau gugggucugu                                                   20


<210>  20360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20360
aauguggguc uguuuuuuug                                                   20


<210>  20361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20361
agccuaggcc ugcagcgcca                                                   20


<210>  20362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20362
cacaacggcu ucuuggaggc                                                   20


<210>  20363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20363
uggaggcuac ugucagaaaa                                                   20


<210>  20364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20364
gacaguagcc uccaagaagc                                                   20


<210>  20365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20365
aauuuucuca gaacuuaagg                                                   20


<210>  20366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20366
cagaacuuaa gggcucucga                                                   20


<210>  20367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20367
gagaaaauuu gaagccccca                                                   20


<210>  20368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20368
auccgaaaac ugccacacau                                                   20


<210>  20369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20369
gauggaagcu cgagagcccu                                                   20


<210>  20370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20370
gcguaguacc cagagagcuc                                                   20


<210>  20371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20371
cacaccccca uucggcguag                                                   20


<210>  20372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20372
ucacacaccc ccauucggcg                                                   20


<210>  20373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20373
agguucuuca cacaccccca                                                   20


<210>  20374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20374
cccuccucug ucuccaaccu                                                   20


<210>  20375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20375
guucucuaac uagcuuuuua                                                   20


<210>  20376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20376
cuaacuagcu uuuuaaaaau                                                   20


<210>  20377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20377
aauuuuuaaa aagcuaguua                                                   20


<210>  20378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20378
aacucagccu ccccucccca                                                   20


<210>  20379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20379
caugccuccc ucccuuccgu                                                   20


<210>  20380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20380
guccccccaa ggaggaccca                                                   20


<210>  20381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20381
aggugugucc cgaguuuauu                                                   20


<210>  20382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20382
uuccaggugu gucccgaguu                                                   20


<210>  20383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20383
cagucauaag ggcaaguguu                                                   20


<210>  20384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20384
uacuaaguuu ucucagucau                                                   20


<210>  20385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20385
cuccucccuc ucccgcucuc                                                   20


<210>  20386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20386
caaaauaaua auaaaauuau                                                   20


<210>  20387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20387
uuauaauuuu auuauuauuu                                                   20


<210>  20388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20388
uugugcugcu uuuacaucag                                                   20


<210>  20389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20389
uguuuucguu gugcugcuuu                                                   20


<210>  20390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20390
acgucaaagc agccaaugau                                                   20


<210>  20391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20391
ccucuuguaa aucauuggcu                                                   20


<210>  20392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20392
gagauuuguu cgccucuugu                                                   20


<210>  20393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20393
cuucagagau uuguucgccu                                                   20


<210>  20394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20394
gguuuucucu ucagagauuu                                                   20


<210>  20395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20395
uucaaacaug caguuuucuu                                                   20


<210>  20396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20396
aacaugcagu uuucuuuucu                                                   20


<210>  20397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20397
uuucuuuuuu ggaaggggga                                                   20


<210>  20398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20398
uuuuuggaag ggggaaggca                                                   20


<210>  20399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20399
aaaaaagaaa agaaaacugc                                                   20


<210>  20400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20400
cccuuccaaa aaagaaaaga                                                   20


<210>  20401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20401
ccauugccuu cccccuucca                                                   20


<210>  20402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20402
cuucaccauu gccuuccccc                                                   20


<210>  20403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20403
ucccuucacc auugccuucc                                                   20


<210>  20404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20404
uccgggguuc cucccuugcu                                                   20


<210>  20405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20405
ucccuugcug uggacauuga                                                   20


<210>  20406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20406
agucaauguc cacagcaagg                                                   20


<210>  20407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20407
gcugcuucaa gucaaugucc                                                   20


<210>  20408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20408
ucggcacauc cggacuccca                                                   20


<210>  20409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20409
aggccucguu gccauggcga                                                   20


<210>  20410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20410
ggucgccaug gcaacgaggc                                                   20


<210>  20411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20411
ggggaauccc auucccaguc                                                   20


<210>  20412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20412
ccagaaccca ccuggacgca                                                   20


<210>  20413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20413
caguccagcg cuaagucacu                                                   20


<210>  20414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20414
uccaaccugc uaccaauauu                                                   20


<210>  20415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20415
aauucuaaua gacaaaguau                                                   20


<210>  20416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20416
aauagacaaa guauaucaug                                                   20


<210>  20417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20417
cagcuauuua aaagcacagc                                                   20


<210>  20418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20418
ccaaguaucc ucuaaagcgg                                                   20


<210>  20419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20419
accaucccua ugaaagaucu                                                   20


<210>  20420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20420
uagggauggu agaaaaggca                                                   20


<210>  20421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20421
agggagcacg uguaucagau                                                   20


<210>  20422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20422
guaaaguggc aaaaacuauu                                                   20


<210>  20423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20423
uuucuguaaa guggcaaaaa                                                   20


<210>  20424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20424
gccaaguuua gguucucaag                                                   20


<210>  20425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20425
caaguacaau gacccgugug                                                   20


<210>  20426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20426
cacgggucau uguacuugag                                                   20


<210>  20427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20427
cauuuggaag ggaggaauua                                                   20


<210>  20428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20428
aaaugggaaa gagaccaauc                                                   20


<210>  20429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20429
ucccuuccaa augggaaaga                                                   20


<210>  20430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20430
cagcgucauc uacggucaug                                                   20


<210>  20431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20431
cucucucuau uucccagcgu                                                   20


<210>  20432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20432
cucucucucu cucucuuucu                                                   20


<210>  20433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20433
ccuaaaggcu gagucacugg                                                   20


<210>  20434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20434
gcuugcuggc aucucguuau                                                   20


<210>  20435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20435
uagcuauagc agcccuagag                                                   20


<210>  20436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20436
cucuaugugu ucugaugucc                                                   20


<210>  20437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20437
gauguccauu ucucuaacaa                                                   20


<210>  20438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20438
cuaacaaugg guucguuuau                                                   20


<210>  20439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20439
uuuauuuucu auugggaaau                                                   20


<210>  20440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20440
auugggaaau augcagggcu                                                   20


<210>  20441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20441
caauagaaaa uaaacgaacc                                                   20


<210>  20442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20442
uaguugucuc cuaaagcccu                                                   20


<210>  20443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20443
uaaaagacug cuaacuuuua                                                   20


<210>  20444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20444
aagcagguug agagaacucu                                                   20


<210>  20445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20445
cucaaccugc uuggaaaaau                                                   20


<210>  20446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20446
cacaauuuuu uuuuuauggg                                                   20


<210>  20447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20447
cauaaaaaaa aaauuguggg                                                   20


<210>  20448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20448
gacaacuucc cauaaaaaaa                                                   20


<210>  20449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20449
cuuuuuuuca gacaacuucc                                                   20


<210>  20450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20450
ugaacacacc aggcccaggg                                                   20


<210>  20451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20451
ggaauguacc caucccauuc                                                   20


<210>  20452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20452
guuacuccau ugucccuggg                                                   20


<210>  20453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20453
ucauuacgau ucuguuacuc                                                   20


<210>  20454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20454
uaugacugug uuguaacugu                                                   20


<210>  20455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20455
uguguguacg gagggggaaa                                                   20


<210>  20456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20456
cccuccguac acacaugaac                                                   20


<210>  20457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20457
uguuuuaagc cucuuuuccc                                                   20


<210>  20458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20458
ucccucaguc ucugugagca                                                   20


<210>  20459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20459
caacuccuuu ucaggaaggc                                                   20


<210>  20460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20460
ggaaggcccg aaauaauccc                                                   20


<210>  20461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20461
ugaaaaggag uugagaagcc                                                   20


<210>  20462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20462
ggccuuccug aaaaggaguu                                                   20


<210>  20463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20463
gcaaacugug ucugugaaua                                                   20


<210>  20464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20464
cagacacagu uugcugaaag                                                   20


<210>  20465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20465
uuauuucucc aauuggaauu                                                   20


<210>  20466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20466
ccaauuggaa uuauaccuaa                                                   20


<210>  20467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20467
aauuggagaa auaaggaaau                                                   20


<210>  20468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20468
uuucaaguuc ucacuucuag                                                   20


<210>  20469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20469
aguucucacu ucuagcauua                                                   20


<210>  20470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20470
cacuucuagc auuaugauua                                                   20


<210>  20471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20471
agcauuauga uuauauacaa                                                   20


<210>  20472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20472
auaucuacag aaugcccugg                                                   20


<210>  20473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20473
guagauauag aacuguuuau                                                   20


<210>  20474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20474
cagggcauuc uguagauaua                                                   20


<210>  20475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20475
cacuuucugc cauggccagu                                                   20


<210>  20476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20476
gccauggcca gugcaaauga                                                   20


<210>  20477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20477
uuugcacugg ccauggcaga                                                   20


<210>  20478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20478
ucauuugcac uggccauggc                                                   20


<210>  20479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20479
ccucacuucu uagcaaccuu                                                   20


<210>  20480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20480
uagcaaccuu uguaaugugu                                                   20


<210>  20481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20481
agccuuuuug uagguccuaa                                                   20


<210>  20482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20482
ggaaggaggu aauauaggca                                                   20


<210>  20483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20483
ugaacccauu ugcuauccuc                                                   20


<210>  20484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20484
agugccuaua uuaccuccuu                                                   20


<210>  20485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20485
gguuuaaaau cugugagaaa                                                   20


<210>  20486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20486
cacagauuuu aaaccagaaa                                                   20


<210>  20487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20487
auuucucaca gauuuuaaac                                                   20


<210>  20488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20488
uguuuauuaa guuguucuca                                                   20


<210>  20489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20489
caaaugaaga uuaaaaagaa                                                   20


<210>  20490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20490
uuugagaaca acuuaauaaa                                                   20


<210>  20491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20491
uuuuaaucuu cauuugagaa                                                   20


<210>  20492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20492
gguauguaga gaacauucca                                                   20


<210>  20493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20493
cuacauaccu gaacugaugc                                                   20


<210>  20494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20494
aucagcacgu caagccuguu                                                   20


<210>  20495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20495
uaguaguucc ucauuuaaaa                                                   20


<210>  20496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20496
ucauuuaaaa aaaaaagauc                                                   20


<210>  20497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20497
ugaucuuuuu uuuuuaaaug                                                   20


<210>  20498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20498
ucuuacuauu ggaaaugugc                                                   20


<210>  20499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20499
aauaguaaga ugaauucaug                                                   20


<210>  20500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20500
ggauacaaaa uaucauuuau                                                   20


<210>  20501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20501
cauguuucua uuguucauca                                                   20


<210>  20502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20502
auuguucauc agcuucagaa                                                   20


<210>  20503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20503
ucagcuucag aaauaauauu                                                   20


<210>  20504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20504
gaaauaauau uuuaucagaa                                                   20


<210>  20505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20505
gaagcugaug aacaauagaa                                                   20


<210>  20506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20506
gauaaaauau uauuucugaa                                                   20


<210>  20507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20507
gguuacuuag ucuccugacu                                                   20


<210>  20508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20508
ucagguuacu uagucuccug                                                   20


<210>  20509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20509
ccauuugauu uaagaaauuu                                                   20


<210>  20510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20510
uaaaucaaau ggggaauggg                                                   20


<210>  20511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20511
aauuucuuaa aucaaauggg                                                   20


<210>  20512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20512
gucugucagg augcaaaacc                                                   20


<210>  20513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20513
caguauaugc ugcucuuagc                                                   20


<210>  20514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20514
uuuuaauuuc ucaguauaug                                                   20


<210>  20515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20515
acuccacccu auuaaauguc                                                   20


<210>  20516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20516
ccagugccau gccagcuuua                                                   20


<210>  20517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20517
aucugucuug agcagcauuu                                                   20


<210>  20518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20518
guuuuggaga aaccuaaucc                                                   20


<210>  20519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20519
ccaaaacuga auccaaaaug                                                   20


<210>  20520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20520
aaguucagug acaaacauca                                                   20


<210>  20521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20521
gugacaaaca ucaaguucuc                                                   20


<210>  20522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20522
caagguaccg cacgcccacc                                                   20


<210>  20523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20523
ccaacauccu uucucagugg                                                   20


<210>  20524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20524
caguggauuc cucuagcccc                                                   20


<210>  20525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20525
ucuagcccca cucucuccuu                                                   20


<210>  20526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20526
cacccaaacu ggcuuuucag                                                   20


<210>  20527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20527
gaaaacauug acuuucuuua                                                   20


<210>  20528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20528
gaaaagccag uuuggguggg                                                   20


<210>  20529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20529
uuauacuuua gaaagauaaa                                                   20


<210>  20530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20530
aaaguauaaa gaaagucaau                                                   20


<210>  20531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20531
ugccucagau aaaaggcaug                                                   20


<210>  20532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20532
ugucaugccu uuuaucugag                                                   20


<210>  20533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20533
uaugcccuag ugccugugag                                                   20


<210>  20534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20534
ugugguagca uuuuuugucg                                                   20


<210>  20535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20535
guugucuucu ugugguagca                                                   20


<210>  20536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20536
uauuuuugua aaaaaccaaa                                                   20


<210>  20537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20537
uucaucuaca cugggaacag                                                   20


<210>  20538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20538
ucuacacugg gaacagggac                                                   20


<210>  20539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20539
caguguagau gaaugaauac                                                   20


<210>  20540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20540
aaggauuuuu aaaauagacc                                                   20


<210>  20541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20541
gaccagccag uuaggucuau                                                   20


<210>  20542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20542
auuaucuucu gaccagccag                                                   20


<210>  20543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20543
cgcccuuauu ugcugucauc                                                   20


<210>  20544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20544
uggaugacag caaauaaggg                                                   20


<210>  20545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20545
ugggaucuca gaaccacaag                                                   20


<210>  20546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20546
gagaucccag gaacccuaga                                                   20


<210>  20547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20547
ugagaugcau agugguuugc                                                   20


<210>  20548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20548
aaagauuuca cuaugucugg                                                   20


<210>  20549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20549
cuaugucugg cuacaccccu                                                   20


<210>  20550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20550
uuucuuucgu cucucucuuu                                                   20


<210>  20551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20551
uucgucucuc ucuuuuuuuc                                                   20


<210>  20552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20552
ucucucucuu uuuuucuccc                                                   20


<210>  20553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20553
cccucuuuuu uaaacaaaac                                                   20


<210>  20554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20554
agauuuuuag auuucaaaag                                                   20


<210>  20555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20555
aaaguggggu uauuuuguua                                                   20


<210>  20556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20556
cauaacaaaa uaaccccacu                                                   20


<210>  20557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20557
auguaagagu cuuuucucau                                                   20


<210>  20558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20558
aagauaaagc aaggauggga                                                   20


<210>  20559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20559
cccauccuug cuuuaucuua                                                   20


<210>  20560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20560
auucucccau ccuugcuuua                                                   20


<210>  20561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20561
uuucuauucu cccauccuug                                                   20


<210>  20562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20562
uguugucuaa aaguucuuuu                                                   20


<210>  20563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20563
uuuaaauuuu uugcuguucu                                                   20


<210>  20564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20564
cuuauguuug aauggauuuc                                                   20


<210>  20565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20565
aacauaagug aaaaaacuug                                                   20


<210>  20566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20566
gcuaagagau ggaguaaguu                                                   20


<210>  20567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20567
gucugauguu aaaaacuuac                                                   20


<210>  20568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20568
auuucuugaa aacuauucua                                                   20


<210>  20569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20569
ugaaaacuau ucuaaacugg                                                   20


<210>  20570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20570
agaaauggaa gguguuuuca                                                   20


<210>  20571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20571
aaacuggaaa gccuuaaaac                                                   20


<210>  20572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20572
aguuuagaau aguuuucaag                                                   20


<210>  20573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20573
uuuaggguau aauacacgca                                                   20


<210>  20574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20574
gaugcgugua uuauacccua                                                   20


<210>  20575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20575
augggcauuc ugaugcgugu                                                   20


<210>  20576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20576
ggauuauuuc uaugggcauu                                                   20


<210>  20577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20577
cuuaaaaccu guuauuuucu                                                   20


<210>  20578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20578
ugcaaguaau uuacagagug                                                   20


<210>  20579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20579
uguguccuca uuugacacac                                                   20


<210>  20580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20580
auaaagggac aaaaugggug                                                   20


<210>  20581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20581
uacacccauu uugucccuuu                                                   20


<210>  20582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20582
aauagaacuu aacaaagacc                                                   20


<210>  20583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20583
auuggaaaaa ccacugucug                                                   20


<210>  20584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20584
ggucuuuguu aaguucuauu                                                   20


<210>  20585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20585
uuguuuuuau uuuuuuuuuu                                                   20


<210>  20586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20586
aaacagaggc acuuaauuug                                                   20


<210>  20587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20587
aguuacgaca aacagcuuuc                                                   20


<210>  20588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20588
uuacaggaau agaaaaggcc                                                   20


<210>  20589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20589
uguaaugaaa gcuguuuguc                                                   20


<210>  20590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20590
auuccuguaa ugaaagcugu                                                   20


<210>  20591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20591
gcauugccau uuacaaaaaa                                                   20


<210>  20592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20592
cuuuaauaug cuuugcauau                                                   20


<210>  20593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20593
uaugcaaagc auauuaaaga                                                   20


<210>  20594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20594
uuccaaucua aauauaaagc                                                   20


<210>  20595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20595
aaucuaaaua uaaagcacca                                                   20


<210>  20596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20596
uugccaaaaa cuaaauggug                                                   20


<210>  20597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20597
uuuuuuuuuc uuucuuucuu                                                   20


<210>  20598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20598
uucuuucuuu uacugcauau                                                   20


<210>  20599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20599
uucuuuuacu gcauaugaag                                                   20


<210>  20600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20600
uuuacugcau augaagguaa                                                   20


<210>  20601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20601
uaugcaguaa aagaaagaaa                                                   20


<210>  20602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20602
agcaucuuac cuucauaugc                                                   20


<210>  20603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20603
aucacccuac auuccagcau                                                   20


<210>  20604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20604
uucuaucacc cuacauucca                                                   20


<210>  20605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20605
ugcugccaua cuguaugcag                                                   20


<210>  20606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20606
uuuuuccugc ugccauacug                                                   20


<210>  20607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20607
agcaggcucc cccaaaccgc                                                   20


<210>  20608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20608
caucuguaau gucacacuuu                                                   20


<210>  20609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20609
cucuuuuuuu uuuuuuugaa                                                   20


<210>  20610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20610
aaaaaaaaaa aaagagagaa                                                   20


<210>  20611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20611
acuaccaaaa aagguacauu                                                   20


<210>  20612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20612
cuuaaaaggu aucaauguac                                                   20


<210>  20613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20613
auauaaauac uauagugccu                                                   20


<210>  20614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20614
ucuaguguua ggcacuauag                                                   20


<210>  20615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20615
aauaccauuc uagaaauaca                                                   20


<210>  20616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20616
agaaauacag aaaaaagacc                                                   20


<210>  20617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20617
agaaugguau uugaauuaaa                                                   20


<210>  20618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20618
guauuucuag aaugguauuu                                                   20


<210>  20619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20619
uaugcuaaaa uacauuuaug                                                   20


<210>  20620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20620
uauauuuaag uacuauauaa                                                   20


<210>  20621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20621
ccaauguaug uuuuuuuuuu                                                   20


<210>  20622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20622
gguuguaaaa aaaaaaaaca                                                   20


<210>  20623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20623
augccuugga uacacaccgc                                                   20


<210>  20624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20624
acuaccauuu uuaaauggau                                                   20


<210>  20625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20625
auugucuugg ugguguuaca                                                   20


<210>  20626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20626
ccccuaaaca uaaugaagug                                                   20


<210>  20627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20627
uuauguuuag gggggaacug                                                   20


<210>  20628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20628
uaacauuuau auuuaaaaaa                                                   20


<210>  20629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20629
acagugcaag gauuuuuuug                                                   20


<210>  20630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20630
cuucuacagu gcaaggauuu                                                   20


<210>  20631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20631
uuucuauguu aaguguauuc                                                   20


<210>  20632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20632
auguuaagug uauucuguuu                                                   20


<210>  20633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20633
guuuccauuc acagcgcuug                                                   20


<210>  20634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20634
auucacagcg cuugcaaugu                                                   20


<210>  20635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20635
cagcgcuugc aauguugcgu                                                   20


<210>  20636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20636
auuuuuuuuc agcauucuug                                                   20


<210>  20637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20637
gcauucuugc aacuuuuccc                                                   20


<210>  20638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20638
ugcaacuuuu cccuuaagua                                                   20


<210>  20639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20639
cuuaaguaua gaccuguaaa                                                   20


<210>  20640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20640
caguuuacag gucuauacuu                                                   20


<210>  20641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20641
cuaaucagag auacagaggu                                                   20


<210>  20642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20642
aauagcacuu gacucugccu                                                   20


<210>  20643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20643
uuuuuauuaa gcuagcaucu                                                   20


<210>  20644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20644
uuguuuuuau uuuuauuuuu                                                   20


<210>  20645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20645
auguuaacac aaauagcaca                                                   20


<210>  20646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20646
auacacugug ugcuauuugu                                                   20


<210>  20647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20647
uuuccauaca cugugugcua                                                   20


<210>  20648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20648
uuucuuuucc auacacugug                                                   20


<210>  20649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20649
uucucuucuu uuuuuaagaa                                                   20


<210>  20650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20650
cuucuuuuuu uaagaauguc                                                   20


<210>  20651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20651
uuuuuuaaga augucacauu                                                   20


<210>  20652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20652
uaaaaaaaga agagaaagaa                                                   20


<210>  20653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20653
uaagacuugc auuuaaaugu                                                   20


<210>  20654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20654
uaguuaauca ucauuguauc                                                   20


<210>  20655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20655
aguuuuaaau ggcaaauagu                                                   20


<210>  20656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20656
ucuguucccc ucugucaaac                                                   20


<210>  20657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20657
guuccccucu gucaaaccuu                                                   20


<210>  20658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20658
ccucugucaa accuuauugu                                                   20


<210>  20659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20659
uuucaauaug guauacaagg                                                   20


<210>  20660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20660
auaugguaua caaggucuua                                                   20


<210>  20661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20661
uuuggugcca guauuuuuaa                                                   20


<210>  20662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20662
uaaaaugaac uccuuacuag                                                   20


<210>  20663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20663
uuuuaugaag auauuugcuu                                                   20


<210>  20664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20664
agggcuuuug cacauuacac                                                   20


<210>  20665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20665
auuuaaucau uguuuaaaaa                                                   20


<210>  20666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20666
uuuaagcucu caccaggagc                                                   20


<210>  20667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20667
uuuaguuuaa uuuuauaaac                                                   20


<210>  20668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20668
cacaacaaug gcuaccuaaa                                                   20


<210>  20669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20669
auauuguauu ucucacaaca                                                   20


<210>  20670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20670
uaagguuuau uaccucaccc                                                   20


<210>  20671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20671
gcauugggug agguaauaaa                                                   20


<210>  20672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20672
acuuguuaua aacuuguagc                                                   20


<210>  20673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20673
uucuacuugu uauaaacuug                                                   20


<210>  20674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20674
aucauuuggu uuuaaaauau                                                   20


<210>  20675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20675
guuuuucugu uaauuuguca                                                   20


<210>  20676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20676
guuaauuugu caauucaagg                                                   20


<210>  20677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20677
aggccuuuuu ucuuccuuuc                                                   20


<210>  20678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20678
uccuuuccaa uugauacauu                                                   20


<210>  20679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20679
uuuccaauug auacauuuaa                                                   20


<210>  20680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20680
aauugauaca uuuaacccuu                                                   20


<210>  20681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20681
gugcuaucua uucugucuau                                                   20


<210>  20682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20682
gucuauagag gguuaaucca                                                   20


<210>  20683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20683
uccucacguu auaaaauaaa                                                   20


<210>  20684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20684
guaauacaua ucauguacag                                                   20


<210>  20685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20685
cucucucucu cuuuuucucu                                                   20


<210>  20686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20686
cucagaacgg aacuggaaac                                                   20


<210>  20687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20687
gagagaaaaa gagagagaga                                                   20


<210>  20688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20688
guucugagag aaaaagagag                                                   20


<210>  20689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20689
aguuccguuc ugagagaaaa                                                   20


<210>  20690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20690
uugcugagca aacauguugc                                                   20


<210>  20691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20691
cuugugcaau aauuuacaug                                                   20


<210>  20692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20692
aacggugaga acauaaagga                                                   20


<210>  20693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20693
caccguuuga augcaugauc                                                   20


<210>  20694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20694
uuuauguucu caccguuuga                                                   20


<210>  20695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20695
uuuuuuuuuu uuuuccuuua                                                   20


<210>  20696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20696
uuuuccuuuu uuuuuuuuuu                                                   20


<210>  20697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20697
uuuuucuuuu uccuuuuuuu                                                   20


<210>  20698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20698
uuuucuuuuu ucuuuuuccu                                                   20


<210>  20699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20699
uuuucuuuuu cuuuuuucuu                                                   20


<210>  20700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20700
uagcuucguu acuucuguuu                                                   20


<210>  20701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20701
uuacuucugu uuguuuguuu                                                   20


<210>  20702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20702
guuuguuugu uuguuuguuu                                                   20


<210>  20703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20703
agucccaugu gauuuaaaca                                                   20


<210>  20704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20704
ccaucgcccu ccagccccac                                                   20


<210>  20705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20705
ccacuccccu uccccaucgc                                                   20


<210>  20706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20706
guuuuuauau cauuauucaa                                                   20


<210>  20707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20707
acacucgauc acugugccau                                                   20


<210>  20708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20708
uguguuucuc caggguacug                                                   20


<210>  20709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20709
ccaggguacu guacacgcua                                                   20


<210>  20710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20710
cauuuguaaa cguccuuccc                                                   20


<210>  20711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20711
ccaccuggcc augcguuuuc                                                   20


<210>  20712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20712
ugugccuggu gagcuugcua                                                   20


<210>  20713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20713
cccguguggc uucuccugug                                                   20


<210>  20714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20714
ccuguggaca gugagauugc                                                   20


<210>  20715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20715
ugaagacuuu cccacaguac                                                   20


<210>  20716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20716
agaacuguag caaucucacu                                                   20


<210>  20717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20717
cacaguacuc acaagugucg                                                   20


<210>  20718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20718
cgugccgcug cgccccgaga                                                   20


<210>  20719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20719
ccacaccgcc cggggagcug                                                   20


<210>  20720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20720
ccgaggagug cuccgacgag                                                   20


<210>  20721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20721
gagacuccag acaaucgccu                                                   20


<210>  20722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20722
uuagcuucgg agacuccaga                                                   20


<210>  20723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20723
ccguguuggg caucgcggcc                                                   20


<210>  20724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20724
accugccccc ggccgcgaug                                                   20


<210>  20725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20725
cgagcuugau gcgcuuagag                                                   20


<210>  20726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20726
cuaagcgcau caagcucgag                                                   20


<210>  20727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20727
ucgcaagugu cccuguggcc                                                   20


<210>  20728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20728
cgcccaggac cugguggaag                                                   20


<210>  20729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20729
accagguccu gggcgagaag                                                   20


<210>  20730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20730
gcgaggccuu ccaccagguc                                                   20


<210>  20731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20731
cgugguggcg cgccgccucc                                                   20


<210>  20732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20732
ggcugagccu ggaggcggcg                                                   20


<210>  20733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20733
uccucuucuu ccucuuccuc                                                   20


<210>  20734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20734
uccucuuccu cgucguccuc                                                   20


<210>  20735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20735
ucuuccucgu cguccuccuc                                                   20


<210>  20736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20736
ucgucguccu ccucuuccuc                                                   20


<210>  20737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20737
uccucguccc cguucuccgg                                                   20


<210>  20738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20738
ccgggaucag guuggggucg                                                   20


<210>  20739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20739
cgcucuugaa cuuggccacc                                                   20


<210>  20740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20740
agagcgagaa cgaccccaac                                                   20


<210>  20741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20741
ggggagcugg cgguggagag                                                   20


<210>  20742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20742
uguggcgcuu cagcuugcug                                                   20


<210>  20743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20743
gcuugcuggc cugggugcac                                                   20


<210>  20744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20744
cgcccgugug gcugcgccgg                                                   20


<210>  20745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20745
gagcaaccug guggugcacc                                                   20


<210>  20746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20746
aauuucagag caaccuggug                                                   20


<210>  20747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20747
gcggcaagac guucaaauuu                                                   20


<210>  20748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20748
uggcgacgcc cccccucccu                                                   20


<210>  20749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20749
agccagguag caagccgccc                                                   20


<210>  20750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20750
cugccagcuc ucuaagucuc                                                   20


<210>  20751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20751
cuaggagacu uagagagcug                                                   20


<210>  20752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20752
accgcagcac ccugucaaag                                                   20


<210>  20753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20753
gcccccaggc gcucuaugcg                                                   20


<210>  20754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20754
acccacuccc ccccuguuua                                                   20


<210>  20755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20755
gccaggccgg aagccucucu                                                   20


<210>  20756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20756
ggccuggcag aagggcgcuu                                                   20


<210>  20757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20757
uagcagguua aagggguuau                                                   20


<210>  20758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20758
uauugcagac aauaaccccu                                                   20


<210>  20759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20759
cagccaccuc uccaugggau                                                   20


<210>  20760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20760
gcaccuaguc cugaagggau                                                   20


<210>  20761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20761
ggacuaggug cagaaugucc                                                   20


<210>  20762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20762
guguucgcuu ucuaaguaga                                                   20


<210>  20763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20763
cuuucuaagu agauucuuaa                                                   20


<210>  20764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20764
aaguagauuc uuaauccaug                                                   20


<210>  20765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20765
uaauccauga guguucugug                                                   20


<210>  20766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20766
gugcguguug caagagaaac                                                   20


<210>  20767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20767
cuugcaacac gcacagaaca                                                   20


<210>  20768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20768
ccagugcaug guuucucuug                                                   20


<210>  20769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20769
accuccagcc uucccugccc                                                   20


<210>  20770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20770
cugcccccac cccucaaccc                                                   20


<210>  20771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20771
ugccauuaaa cucaguucua                                                   20


<210>  20772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20772
agaaauuuua uauccaaucc                                                   20


<210>  20773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20773
agaacugagu uuaauggcag                                                   20


<210>  20774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20774
gcuuugggga uuggauauaa                                                   20


<210>  20775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20775
ggcuugagga ugaagguccc                                                   20


<210>  20776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20776
uccucaagcc agaacugguc                                                   20


<210>  20777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20777
aggcaccuca acaaaugucu                                                   20


<210>  20778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20778
aaacuuucca guuccaucag                                                   20


<210>  20779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20779
aguuccauca gcuguaguuu                                                   20


<210>  20780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20780
aucagcugua guuuggggca                                                   20


<210>  20781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20781
uccuuguuaa gugagaaacu                                                   20


<210>  20782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20782
cacuuaacaa ggaggaaaca                                                   20


<210>  20783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20783
uugggucacc uuguccaagu                                                   20


<210>  20784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20784
uaaaucccag cuuucuauuc                                                   20


<210>  20785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20785
auuccccccu gggugacagg                                                   20


<210>  20786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20786
ccccugggug acaggugaac                                                   20


<210>  20787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20787
ccugucaccc aggggggaau                                                   20


<210>  20788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20788
aaauaggcaa acauuucaua                                                   20


<210>  20789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20789
uagagguauc aaaaaagggg                                                   20


<210>  20790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20790
ccuuuuuuga uaccucuaug                                                   20


<210>  20791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20791
uccccuuuuu ugauaccucu                                                   20


<210>  20792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20792
auggcccuaa agaugcuuuc                                                   20


<210>  20793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20793
gcauuagccu gaaacacacu                                                   20


<210>  20794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20794
ggcuaaugcu gaaagcaucu                                                   20


<210>  20795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20795
guggaaaaaa gacuagcaac                                                   20


<210>  20796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20796
acggaaguau uuuaugagua                                                   20


<210>  20797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20797
cacaccccag acugugggag                                                   20


<210>  20798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20798
acaacacccc auggggacgu                                                   20


<210>  20799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20799
uugagauaaa aauggacguc                                                   20


<210>  20800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20800
gauuuuuuaa acauucuuug                                                   20


<210>  20801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20801
uucagauuuu uuaaacauuc                                                   20


<210>  20802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20802
uucagauuua acggauaggc                                                   20


<210>  20803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20803
gauuuaacgg auaggcugua                                                   20


<210>  20804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20804
agacuugcau uugucugacc                                                   20


<210>  20805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20805
uuaaacuagg augcuguguc                                                   20


<210>  20806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20806
cagccugcug ccugucaugg                                                   20


<210>  20807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20807
cguuguuagc cucucaaaac                                                   20


<210>  20808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20808
caacuggagc ugagucccag                                                   20


<210>  20809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20809
uucucaacug gagcugaguc                                                   20


<210>  20810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20810
guuucuuucu caacuggagc                                                   20


<210>  20811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20811
gcuagucaac ucuggccagu                                                   20


<210>  20812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20812
cuugcugaaa agaacccaag                                                   20


<210>  20813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20813
gcaagggaaa uaaugugacu                                                   20


<210>  20814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20814
uuucagcaag ggaaauaaug                                                   20


<210>  20815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20815
uugccaaagu ggcauuuacc                                                   20


<210>  20816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20816
caaaauauuu cauuugggga                                                   20


<210>  20817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20817
uuuggggaga uggcuaaauu                                                   20


<210>  20818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20818
auauauauau auauuuaaug                                                   20


<210>  20819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20819
gcccuuuuua auguugcagu                                                   20


<210>  20820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20820
cauccucguc cuuuggcuac                                                   20


<210>  20821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20821
cagagauucu gaaaaaaaaa                                                   20


<210>  20822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20822
gaaaaaaaaa gccuuaaaau                                                   20


<210>  20823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20823
gaaucucugg gaaguuuugu                                                   20


<210>  20824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20824
caguuauauu uuaaggcuuu                                                   20


<210>  20825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20825
ccuucuuuua aaagaagggc                                                   20


<210>  20826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20826
uuuaaaagaa gggcugcaag                                                   20


<210>  20827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20827
uuuaaaagaa ggagaaaagu                                                   20


<210>  20828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20828
uuaaggccac agcuaguauu                                                   20


<210>  20829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20829
aagaaggaaa aaaaaaaaaa                                                   20


<210>  20830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20830
uagaaaguua cugacaaaua                                                   20


<210>  20831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20831
uucuuagaaa guuacugaca                                                   20


<210>  20832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20832
cacucuuaac cucccuggua                                                   20


<210>  20833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20833
ucauucucac ucuuaaccuc                                                   20


<210>  20834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20834
gacuugcuaa auggaggcau                                                   20


<210>  20835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20835
uucugacuug cuaaauggag                                                   20


<210>  20836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20836
caggagcccc caaacacugg                                                   20


<210>  20837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20837
aaaauaagcc agccucgcuc                                                   20


<210>  20838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20838
aacauuuguc uaauguggaa                                                   20


<210>  20839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20839
acauuagaca aauguuugaa                                                   20


<210>  20840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20840
cccuuccaca uuagacaaau                                                   20


<210>  20841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20841
gccuuuuuuc ccccuuccac                                                   20


<210>  20842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20842
aaaucuuucu gccuuuuuuc                                                   20


<210>  20843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20843
uucaaaaucu uucugccuuu                                                   20


<210>  20844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20844
aagggaaaua aaaagcuuca                                                   20


<210>  20845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20845
cuuugaagag aggaggcaaa                                                   20


<210>  20846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20846
uugagaacau uuuuauaaau                                                   20


<210>  20847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20847
caaugaagcu uuuuauuucc                                                   20


<210>  20848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20848
acaacaacaa aaaauuuaua                                                   20


<210>  20849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20849
agccuauuug ggacccaagu                                                   20


<210>  20850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20850
aacuacauga uccucugugg                                                   20


<210>  20851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20851
uccuuguccu cccuagaucu                                                   20


<210>  20852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20852
uauuuagccu gacgaucuga                                                   20


<210>  20853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20853
ucacuccaaa ugccuuaaaa                                                   20


<210>  20854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20854
aucgauguuu uauaagguaa                                                   20


<210>  20855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20855
caugugccau gaauuguagu                                                   20


<210>  20856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20856
uggcacaugu gaaaccagca                                                   20


<210>  20857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20857
aaaaggcuua aaugagaaaa                                                   20


<210>  20858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20858
cauuuaagcc uuuuugaaag                                                   20


<210>  20859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20859
gagccaguua ugugaucaug                                                   20


<210>  20860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20860
cugaccugau guaugagaga                                                   20


<210>  20861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20861
cuaucgcauu uuaguauucc                                                   20


<210>  20862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20862
caucaacuag auauucuaga                                                   20


<210>  20863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20863
agaucaugag ggcagcuagu                                                   20


<210>  20864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20864
cauugacauu augauuacac                                                   20


<210>  20865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20865
aagcagcucu cuccauguaa                                                   20


<210>  20866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20866
ccauauaauc uguauuucac                                                   20


<210>  20867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20867
cucagcucau gccgguguac                                                   20


<210>  20868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20868
aaauuccuaa acugcaguca                                                   20


<210>  20869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20869
uaaacugcag ucaucaauaa                                                   20


<210>  20870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20870
caaauuaugg caaguaacac                                                   20


<210>  20871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20871
uaacaucuuu gaugauuuag                                                   20


<210>  20872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20872
aaaucaucaa agauguuaug                                                   20


<210>  20873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20873
agucuuucua aaucaucaaa                                                   20


<210>  20874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20874
uguguggcaa aauuagggcu                                                   20


<210>  20875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20875
ucauuuacuc ugaugaaaau                                                   20


<210>  20876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20876
uuuacucuga ugaaaaucaa                                                   20


<210>  20877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20877
ucagaguaaa ugaagaauau                                                   20


<210>  20878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20878
caauuugaga gccucauugg                                                   20


<210>  20879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20879
uaugcuuagg ggccaggugu                                                   20


<210>  20880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20880
uuuuacuuua ugggaaggaa                                                   20


<210>  20881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20881
cauaaaguaa aaugaaauaa                                                   20


<210>  20882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20882
uucccauaaa guaaaaugaa                                                   20


<210>  20883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20883
aguaugucac caaugugaaa                                                   20


<210>  20884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20884
cauuggugac auacuagaaa                                                   20


<210>  20885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20885
gaagaacaag gaggucugag                                                   20


<210>  20886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20886
gaaucuugag gcuuagauca                                                   20


<210>  20887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20887
ucugaaucuu gaggcuuaga                                                   20


<210>  20888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20888
cugagucuug gaauuccuau                                                   20


<210>  20889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20889
aagacucaga gaaaucaaau                                                   20


<210>  20890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20890
uaucuguaaa augagcauaa                                                   20


<210>  20891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20891
uacagguacu guuuuuaugc                                                   20


<210>  20892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20892
caacaauucu uacagguacu                                                   20


<210>  20893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20893
aaugacagaa guauauaaaa                                                   20


<210>  20894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20894
gucauuugaa cuucccaaca                                                   20


<210>  20895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20895
accugauagu uuacagaggg                                                   20


<210>  20896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20896
cauucgaccu gauaguuuac                                                   20


<210>  20897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20897
uuacuaccag gggugauuaa                                                   20


<210>  20898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20898
ggguguguaa ugugguuagu                                                   20


<210>  20899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20899
agaggaaggu cccaguccag                                                   20


<210>  20900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20900
ucuggaagcc guucggggug                                                   20


<210>  20901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20901
cuguggccac ucugcugugu                                                   20


<210>  20902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20902
agagcucaua gcacuucccu                                                   20


<210>  20903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20903
acuuggcggc auuaaccugc                                                   20


<210>  20904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20904
agagcuuucu ggacccccac                                                   20


<210>  20905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20905
ggacccccac aacccacuuc                                                   20


<210>  20906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20906
acauaccuug uucuggucac                                                   20


<210>  20907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20907
ggucacuccu aaauuggucc                                                   20


<210>  20908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20908
cacaaaggga ggguacauag                                                   20


<210>  20909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20909
cuaucaagcu cagacuuucc                                                   20


<210>  20910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20910
uaccagucaa aucaaacucc                                                   20


<210>  20911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20911
ugagggcugg gaguuugauu                                                   20


<210>  20912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20912
gccuggucuu ccugagggcu                                                   20


<210>  20913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20913
cggucuucag ccuggucuuc                                                   20


<210>  20914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20914
cuggcaacag cccuuggccu                                                   20


<210>  20915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20915
gaggagggug gaguugagag                                                   20


<210>  20916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20916
aucccuuccc uccaaaagug                                                   20


<210>  20917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20917
cuccaaaagu ggcuccguuu                                                   20


<210>  20918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20918
acagccccau gcaggcccca                                                   20


<210>  20919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20919
agucccugca ugcuggcugg                                                   20


<210>  20920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20920
gcaaucugug accuaaccca                                                   20


<210>  20921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20921
cccaagcugg gccuaagccu                                                   20


<210>  20922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20922
gggguuaaaa gcaccucauc                                                   20


<210>  20923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20923
uaagcccuca gguccugagg                                                   20


<210>  20924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20924
cacaauaacu cuuuguuacc                                                   20


<210>  20925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20925
aagccaguug uuuauuuuug                                                   20


<210>  20926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20926
gauaccauuu acaagauggg                                                   20


<210>  20927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20927
cucuccauga ccuuuuuccu                                                   20


<210>  20928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20928
uuuucuuuuu uuuucuuucc                                                   20


<210>  20929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20929
uuuuuuuucu uuccacagca                                                   20


<210>  20930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20930
uuccacagca gguuauuuuu                                                   20


<210>  20931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20931
acagcagguu auuuuucauu                                                   20


<210>  20932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20932
uuuacuuuca aauaaaaauu                                                   20


<210>  20933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20933
aauaaaaauu agaugucaca                                                   20


<210>  20934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20934
uuucuucuug aaccugcuuu                                                   20


<210>  20935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20935
ucuugaaccu gcuuuuuugu                                                   20


<210>  20936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20936
ugaaccugcu uuuuuguguu                                                   20


<210>  20937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20937
agaagaaaag aagugugaca                                                   20


<210>  20938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20938
acccuaaaca caaaaaagca                                                   20


<210>  20939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20939
uaccaugugu uccuacacag                                                   20


<210>  20940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20940
uacacagaga agcaaacugu                                                   20


<210>  20941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20941
cuguguagga acacauggua                                                   20


<210>  20942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20942
aaaacaguau cuuucagaaa                                                   20


<210>  20943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20943
gaaaacauuu guauaaaugg                                                   20


<210>  20944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20944
gaaagauacu guuuuagaaa                                                   20


<210>  20945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20945
uaaaaugguc ccuacuauaa                                                   20


<210>  20946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20946
agugagcuuu uauaguaggg                                                   20


<210>  20947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20947
cauuuuaacu acaaugaugu                                                   20


<210>  20948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20948
cuaaaaccag gagaaaaauu                                                   20


<210>  20949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20949
ccugguuuua gagaaaaaug                                                   20


<210>  20950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20950
ugcccacaca uaauuuugac                                                   20


<210>  20951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20951
aauacacaug uaaauacaua                                                   20


<210>  20952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20952
uuauguauuu acauguguau                                                   20


<210>  20953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20953
aaugcauauu ccuuauguau                                                   20


<210>  20954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20954
agaguuauuc caaugcauau                                                   20


<210>  20955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20955
ggccuuggcu aaagaugugu                                                   20


<210>  20956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20956
cuccuguggc cucauuuagg                                                   20


<210>  20957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20957
aucacuagcc acggagcaag                                                   20


<210>  20958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20958
ccccaggguc uugucuugcu                                                   20


<210>  20959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20959
ucacuggagg cugggagcug                                                   20


<210>  20960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20960
uuccucacug gaggcuggga                                                   20


<210>  20961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20961
cuccccuuuu ucuuuccuca                                                   20


<210>  20962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20962
ucccuccccu uuuucuuucc                                                   20


<210>  20963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20963
auuacucacu uggcagccgc                                                   20


<210>  20964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20964
aaaauagauu gucauaugua                                                   20


<210>  20965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20965
guacuuaaaa aguaagggca                                                   20


<210>  20966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20966
agaaauucuc aucucuauac                                                   20


<210>  20967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20967
ggaaauugcc cuuacuuuuu                                                   20


<210>  20968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20968
caucucuaua cacauggaca                                                   20


<210>  20969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20969
acaaaugucc auguguauag                                                   20


<210>  20970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20970
ucuacaaaug uccaugugua                                                   20


<210>  20971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20971
gcacucaucc caggcguggg                                                   20


<210>  20972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20972
gcacauggag cucuaauccc                                                   20


<210>  20973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20973
gcacuggagg ggccucuccu                                                   20


<210>  20974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20974
cagauaaacu ucugcacugg                                                   20


<210>  20975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20975
uucacagaua aacuucugca                                                   20


<210>  20976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20976
auuccauuaa aauagauuac                                                   20


<210>  20977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20977
auuaaaauag auuacaacau                                                   20


<210>  20978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20978
ggccuugggc cuguuaacua                                                   20


<210>  20979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20979
uuuguuucag gccuugggcc                                                   20


<210>  20980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20980
cagaguuucu guuuuguuuu                                                   20


<210>  20981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20981
guuuuguuuu caauuucggu                                                   20


<210>  20982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20982
auuucggucu uuuugacaaa                                                   20


<210>  20983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20983
gucuuuuuga caaaagugaa                                                   20


<210>  20984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20984
cuuuugucaa aaagaccgaa                                                   20


<210>  20985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20985
uaaaacaaac ccuuucacuu                                                   20


<210>  20986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20986
uuugcuuauu uauuuguugu                                                   20


<210>  20987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20987
acaagacaau aaucaaacaa                                                   20


<210>  20988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20988
uuccacaaga caauaaucaa                                                   20


<210>  20989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20989
ccuugcugcu uacacaucuu                                                   20


<210>  20990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20990
aggcuaccca caauauuacc                                                   20


<210>  20991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20991
uaucagcauu uugcuuuuug                                                   20


<210>  20992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20992
caaaucuacu cauuuccuau                                                   20


<210>  20993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20993
cugucccucu gccccccucu                                                   20


<210>  20994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20994
caugcuauau uuaugauagc                                                   20


<210>  20995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20995
gugauagggg aaaccugggc                                                   20


<210>  20996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20996
ccuaucacug aaggcgcuau                                                   20


<210>  20997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20997
ggacugagcu gggccauacu                                                   20


<210>  20998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20998
agaguauggc ccagcucagu                                                   20


<210>  20999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  20999
aguugacagg auucuagagu                                                   20


<210>  21000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21000
cacaauacaa agcaauggaa                                                   20


<210>  21001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21001
auugcuuugu auugugagaa                                                   20


<210>  21002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21002
gggguccaaa uaacuuugac                                                   20


<210>  21003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21003
uugucauuua auggucaaag                                                   20


<210>  21004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21004
uuccuuguca uuuaaugguc                                                   20


<210>  21005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21005
aauaaugcca gcacccagaa                                                   20


<210>  21006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21006
gggugcuggc auuauuggaa                                                   20


<210>  21007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21007
ccauuuuacu gcacuuuguu                                                   20


<210>  21008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21008
ccagaguaca acaaagugca                                                   20


<210>  21009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21009
cacacuaaua aaaugaaucu                                                   20


<210>  21010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21010
uuuuauuagu gugagaaguc                                                   20


<210>  21011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21011
uugacuauua gauucauuuu                                                   20


<210>  21012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21012
caaaaaaauc ucagugcuac                                                   20


<210>  21013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21013
ucuucucaaa aaaaucucag                                                   20


<210>  21014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21014
aaguccuccu cuagcuaacu                                                   20


<210>  21015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21015
agagguuugg aguucaugau                                                   20


<210>  21016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21016
ugaugauugg ggagggcggg                                                   20


<210>  21017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21017
ugucucccgc ccuccccaau                                                   20


<210>  21018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21018
ccaucaaagu cuguuuuucu                                                   20


<210>  21019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21019
auuagcuuaa uauuaagagc                                                   20


<210>  21020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21020
aagugcucuu aauauuaagc                                                   20


<210>  21021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21021
ccuuauauag agcacacugc                                                   20


<210>  21022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21022
uuucgcaagg agccuggugg                                                   20


<210>  21023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21023
caaggagccu gguggguaac                                                   20


<210>  21024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21024
cagcagcaca ccaucguuac                                                   20


<210>  21025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21025
cucugcaggc cugguaacag                                                   20


<210>  21026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21026
accagggcuu cccucugcag                                                   20


<210>  21027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21027
caggcuaggu ggugcuucca                                                   20


<210>  21028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21028
uccucucuga cccaaaacaa                                                   20


<210>  21029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21029
cuuuguggug uuuauuuugu                                                   20


<210>  21030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21030
ugcuuguguu gguucacuuu                                                   20


<210>  21031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21031
cuugacguaa acagucaaau                                                   20


<210>  21032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21032
augagaaauc ugagaaucca                                                   20


<210>  21033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21033
cauugaaaaa uaccaugaca                                                   20


<210>  21034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21034
cagauuucuc auugaaaaau                                                   20


<210>  21035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21035
cuaaguuugc ugccaaaaca                                                   20


<210>  21036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21036
uaggaaacac aggcaaccca                                                   20


<210>  21037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21037
uaagaaaagg augucuguuu                                                   20


<210>  21038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21038
aauucucugc cacuuacucu                                                   20


<210>  21039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21039
cugccacuua cucugggaag                                                   20


<210>  21040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21040
cagaguaagu ggcagagaau                                                   20


<210>  21041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21041
gggucucuuc ccagaguaag                                                   20


<210>  21042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21042
gcaggccucc agcaagaaau                                                   20


<210>  21043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21043
ugcuggaggc cugcugaagc                                                   20


<210>  21044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21044
cccauuucuu gcuggaggcc                                                   20


<210>  21045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21045
ugcgaggggc uaggcaugga                                                   20


<210>  21046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21046
aaguuguaaa aaacccuagc                                                   20


<210>  21047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21047
uuuuacagau ggggaaacug                                                   20


<210>  21048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21048
ccaucuguaa aaugaaggga                                                   20


<210>  21049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21049
cauggccuca guuuccccau                                                   20


<210>  21050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21050
cauugugguu aaucaucagu                                                   20


<210>  21051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21051
aaucuucaca uugugguuaa                                                   20


<210>  21052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21052
ugggaauuug ucucuucccc                                                   20


<210>  21053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21053
caggaaagac cacuggauca                                                   20


<210>  21054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21054
ccccugcugc uccugccgug                                                   20


<210>  21055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21055
cugcccaaca agaagguccu                                                   20


<210>  21056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21056
uguugggcag ugaagaccac                                                   20


<210>  21057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21057
acugauccau uaagcaguac                                                   20


<210>  21058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21058
aaaggugcca augaacugac                                                   20


<210>  21059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21059
aaagccccau guagcgcugc                                                   20


<210>  21060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21060
uuggcaccuu ucgaaagccc                                                   20


<210>  21061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21061
aauugugaga ccaagucagu                                                   20


<210>  21062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21062
cccucuaccu cugcuucccc                                                   20


<210>  21063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21063
ccugcagaau uagacagcua                                                   20


<210>  21064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21064
gcaggggaag cagagguaga                                                   20


<210>  21065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21065
aucagccuaa gaagcuauuu                                                   20


<210>  21066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21066
uaggcugaua gaaauguuuu                                                   20


<210>  21067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21067
aaaguaaaua gcuucuuagg                                                   20


<210>  21068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21068
uucaggaaga gggucaaagc                                                   20


<210>  21069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21069
ggaagagggu caaagcaaag                                                   20


<210>  21070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21070
ugaaggaaga uaaaugcaag                                                   20


<210>  21071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21071
gcugcuucuu ccacuaaaca                                                   20


<210>  21072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21072
uccacuaaac acauccauaa                                                   20


<210>  21073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21073
acuaaacaca uccauaauau                                                   20


<210>  21074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21074
cuuugguaag uaaaaucgac                                                   20


<210>  21075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21075
cacaugaacu ggaaaugcua                                                   20


<210>  21076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21076
ugugggaaug ucgauuuuac                                                   20


<210>  21077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21077
aguucaugug ggaaugucga                                                   20


<210>  21078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21078
ugcuaugaug ccuucaauua                                                   20


<210>  21079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21079
auuauuucau cacggcuuag                                                   20


<210>  21080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21080
ucacggcuua ggcaaaguaa                                                   20


<210>  21081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21081
gagcgucaaa cucgaggagc                                                   20


<210>  21082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21082
caggccaagg uggggaaaag                                                   20


<210>  21083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21083
ccaccuuggc cugggaaggc                                                   20


<210>  21084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21084
uuucccaccu ucgcuuucau                                                   20


<210>  21085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21085
caccuucgcu uucauucucc                                                   20


<210>  21086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21086
cuuucauucu ccccagccag                                                   20


<210>  21087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21087
uucuccccag ccagagaugg                                                   20


<210>  21088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21088
ccccagccag agaugggcuc                                                   20


<210>  21089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21089
uagccagcaa ccagagccca                                                   20


<210>  21090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21090
uuguuagugc ucuuaggcaa                                                   20


<210>  21091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21091
cacagcgcag acccaggccc                                                   20


<210>  21092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21092
aaaugcaaau ucuugggcac                                                   20


<210>  21093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21093
ugggcaccac cucagacuua                                                   20


<210>  21094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21094
guaagucuga gguggugccc                                                   20


<210>  21095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21095
gauucaguaa gucugaggug                                                   20


<210>  21096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21096
ccacccucaa uuucugauuc                                                   20


<210>  21097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21097
auguugaaua aauucuccag                                                   20


<210>  21098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21098
acauagaagg cugcuucccc                                                   20


<210>  21099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21099
ccaggugauu cucaugcaca                                                   20


<210>  21100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21100
caugcacacu caagcugaau                                                   20


<210>  21101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21101
gcuugagugu gcaugagaau                                                   20


<210>  21102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21102
cuuacccuaa gacagcagug                                                   20


<210>  21103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21103
uacuucccuu acccuaagac                                                   20


<210>  21104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21104
agcguucaua cuucccuuac                                                   20


<210>  21105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21105
aagcuuccag cguucauacu                                                   20


<210>  21106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21106
cugggcagag acccaugggc                                                   20


<210>  21107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21107
cuccugucca ggacccaccu                                                   20


<210>  21108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21108
aguccuaaag gagguggguc                                                   20


<210>  21109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21109
cuaagcuuaa uuuguuuuug                                                   20


<210>  21110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21110
uaauggaggg auccuuaggg                                                   20


<210>  21111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21111
gguuccaccc uccgucuguc                                                   20


<210>  21112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21112
acccuccguc ugucauugau                                                   20


<210>  21113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21113
cuguccuuau caaugacaga                                                   20


<210>  21114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21114
uagcaugaga caacacccaa                                                   20


<210>  21115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21115
auuaaagccg acaugucagc                                                   20


<210>  21116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21116
cugacauguc ggcuuuaaug                                                   20


<210>  21117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21117
ugcugugucc gugcaguugc                                                   20


<210>  21118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21118
cuuucugguc ucucaaaugg                                                   20


<210>  21119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21119
ggucucucaa augggacaca                                                   20


<210>  21120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21120
cuuuucugac ucaaucuuuu                                                   20


<210>  21121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21121
gacucaaucu uuuuucaaau                                                   20


<210>  21122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21122
aaugucuuac acuuuucugg                                                   20


<210>  21123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21123
gguggaaggu guuucaaccu                                                   20


<210>  21124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21124
accagaaaag uguaagacau                                                   20


<210>  21125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21125
accuguucua uuucauaaag                                                   20


<210>  21126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21126
auuucauaaa ggucucucua                                                   20


<210>  21127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21127
uaaaggucuc ucuagaccca                                                   20


<210>  21128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21128
acuuggggcc ucagaaaugc                                                   20


<210>  21129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21129
gaggccccaa guggaaauac                                                   20


<210>  21130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21130
uuauggcuga auuuaaaaau                                                   20


<210>  21131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21131
gccauaagga aacuuugcaa                                                   20


<210>  21132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21132
gguuucauua aaaaauaugc                                                   20


<210>  21133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21133
uuaaaaaaua ugcagcaaac                                                   20


<210>  21134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21134
caguuugcug cauauuuuuu                                                   20


<210>  21135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21135
acauauauug gguaccaacu                                                   20


<210>  21136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21136
uggaauuuaa gucauuaaau                                                   20


<210>  21137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21137
aggaacaucc cacugggcuu                                                   20


<210>  21138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21138
ucaagaacau cucaaagauu                                                   20


<210>  21139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21139
ugaggaaacc aaaaaacuug                                                   20


<210>  21140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21140
uugacuauua acaugcuauu                                                   20


<210>  21141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21141
gaaacuaauc acugggugug                                                   20


<210>  21142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21142
gaaacaaaua gcauguuaau                                                   20


<210>  21143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21143
aaaugugcca aaacagcuaa                                                   20


<210>  21144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21144
aacacguuua augacugcuu                                                   20


<210>  21145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21145
cuaaaaugua cgugugugug                                                   20


<210>  21146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21146
ugugugugua uaugugagug                                                   20


<210>  21147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21147
cacacguaca cagacacaua                                                   20


<210>  21148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21148
uaaacauaug uuuuuagaua                                                   20


<210>  21149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21149
cuguuuuuuu uuuuuuuuca                                                   20


<210>  21150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21150
gugagacagg cacaaaagca                                                   20


<210>  21151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21151
acgugggaca gcucuacugc                                                   20


<210>  21152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21152
uucacccugg gucuucaaaa                                                   20


<210>  21153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21153
cccugggucu ucaaaaagag                                                   20


<210>  21154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21154
aaaagagaau ggaugacacu                                                   20


<210>  21155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21155
cuuuuugaag acccagggug                                                   20


<210>  21156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21156
caguccauaa uccucaaguc                                                   20


<210>  21157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21157
auguaccacc uucuagacua                                                   20


<210>  21158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21158
agacuacacu uaaaaugcau                                                   20


<210>  21159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21159
ggaugcauuu uaaguguagu                                                   20


<210>  21160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21160
ggguacuuua caaacguuca                                                   20


<210>  21161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21161
uucaggguac uuuacaaacg                                                   20


<210>  21162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21162
aguucugaau ccgauuacua                                                   20


<210>  21163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21163
gaauccgauu acuagguuca                                                   20


<210>  21164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21164
gaacuggaau ggguuccuuc                                                   20


<210>  21165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21165
agccacacaa auaacaacag                                                   20


<210>  21166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21166
uuaccuaacu gcaaaguaaa                                                   20


<210>  21167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21167
auucagccgc aucuagcucu                                                   20


<210>  21168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21168
gccgcaucua gcucuugacc                                                   20


<210>  21169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21169
ucucacuuag auucucugac                                                   20


<210>  21170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21170
cacuuagauu cucugacuua                                                   20


<210>  21171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21171
cugacuuauc agaguauuau                                                   20


<210>  21172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21172
uuacagauug acacaacuca                                                   20


<210>  21173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21173
uaauuaaccu ucugauauug                                                   20


<210>  21174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21174
gauauuguca aaaucgcacu                                                   20


<210>  21175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21175
agaaaugagc auuuacaugu                                                   20


<210>  21176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21176
agaacaaaag agagugcgau                                                   20


<210>  21177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21177
uucauugcuu uuuuacuggc                                                   20


<210>  21178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21178
uugcuuuuuu acuggcuguu                                                   20


<210>  21179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21179
uuaaaaagug uauucugcaa                                                   20


<210>  21180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21180
gcaaaaacaa aagaaagcaa                                                   20


<210>  21181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21181
uuuguuuuug cagaauacac                                                   20


<210>  21182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21182
auauuguagu gucuauaauu                                                   20


<210>  21183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21183
ucccugaaac ucucucaugg                                                   20


<210>  21184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21184
cugaaacucu cucauggucc                                                   20


<210>  21185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21185
gggaagaaau ucuauauugu                                                   20


<210>  21186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21186
uugauacuuc accagugacu                                                   20


<210>  21187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21187
ccagugacuu uaauaacauc                                                   20


<210>  21188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21188
ccuuuuaaga guucuccucc                                                   20


<210>  21189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21189
ccuccuaggc uuuuucucaa                                                   20


<210>  21190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21190
caauaaaggg aggaaguaga                                                   20


<210>  21191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21191
ucccuuuauu gagaaaaagc                                                   20


<210>  21192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21192
gcaagcugug ucuuuaacau                                                   20


<210>  21193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21193
aaaaaaaaaa aaucuugcuu                                                   20


<210>  21194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21194
gaaaagcaac uaagccaaag                                                   20


<210>  21195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21195
gaaaagcaag auuuuuuuuu                                                   20


<210>  21196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21196
aucuuugugu ugaaaugcag                                                   20


<210>  21197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21197
acacaaagau ggaacacaau                                                   20


<210>  21198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21198
cacuaaaagg caaauccuuc                                                   20


<210>  21199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21199
uuucaaaagg uugaauagga                                                   20


<210>  21200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21200
aaagguugaa uaggauggua                                                   20


<210>  21201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21201
accuuuugaa augaaggauu                                                   20


<210>  21202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21202
uuuuuuaagu accauccuau                                                   20


<210>  21203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21203
agcugguuaa auuuagggug                                                   20


<210>  21204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21204
cuccaauaau auucuuuggc                                                   20


<210>  21205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21205
uuggcucugg gcccaaagua                                                   20


<210>  21206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21206
cuugaucgug aauuagauaa                                                   20


<210>  21207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21207
cgaucaagug aaaauacuuu                                                   20


<210>  21208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21208
aaggcaaaag cuuaaagugu                                                   20


<210>  21209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21209
gccauucuaa ggcaaaagcu                                                   20


<210>  21210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21210
caggauaaau uccauucauu                                                   20


<210>  21211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21211
auucauucau ucucucaugc                                                   20


<210>  21212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21212
uucauucucu caugcauuca                                                   20


<210>  21213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21213
uucucucaug cauucauuca                                                   20


<210>  21214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21214
cucaugcauu cauucaaccu                                                   20


<210>  21215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21215
uucaaccucu caugcauuca                                                   20


<210>  21216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21216
accucucaug cauucauuca                                                   20


<210>  21217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21217
uucaacaaau auuuaccgag                                                   20


<210>  21218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21218
acaaauauuu accgagugcc                                                   20


<210>  21219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21219
uuguacugcc cacagcggcu                                                   20


<210>  21220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21220
cccacagcag gcuucauuua                                                   20


<210>  21221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21221
uuuaguagaa aagguaaggc                                                   20


<210>  21222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21222
acuaaaugaa gccugcugug                                                   20


<210>  21223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21223
gugcaggccu uaccuuuucu                                                   20


<210>  21224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21224
acaugggggu agagcaauuu                                                   20


<210>  21225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21225
auagcagcuc aucuguaccu                                                   20


<210>  21226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21226
aaggaagaga aauuauuucc                                                   20


<210>  21227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21227
uuugaauuuc cauagcagcu                                                   20


<210>  21228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21228
cuuccuuuga auuuccauag                                                   20


<210>  21229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21229
auuuggaagg gagggagaga                                                   20


<210>  21230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21230
aaauggaaau aauuucucuu                                                   20


<210>  21231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21231
caaagccucu cucccucccu                                                   20


<210>  21232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21232
ucuuucccaa agccucucuc                                                   20


<210>  21233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21233
cuuggcucuc cagguuuaac                                                   20


<210>  21234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21234
uuuuaucuag gauauccuuu                                                   20


<210>  21235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21235
cucuaagcau cuuuaccugc                                                   20


<210>  21236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21236
caucaaaaua uugcacacug                                                   20


<210>  21237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21237
uccaguugac agcggaggau                                                   20


<210>  21238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21238
gaggauuuau uuagaugguc                                                   20


<210>  21239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21239
gugacaucuu cagcuuucac                                                   20


<210>  21240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21240
gcuuucacaa gugcguauuu                                                   20


<210>  21241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21241
caagugcgua uuuuccaauu                                                   20


<210>  21242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21242
aauuucacau uuucugaaaa                                                   20


<210>  21243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21243
cauuuucuga aaauaaggga                                                   20


<210>  21244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21244
gaaaauaagg gacacaacca                                                   20


<210>  21245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21245
gaaaauguga aauuggaaaa                                                   20


<210>  21246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21246
caagagucca caugguugug                                                   20


<210>  21247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21247
uggaguuuca caagagucca                                                   20


<210>  21248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21248
ucuguucugu uuucccccca                                                   20


<210>  21249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21249
guuuuccccc caccucaauu                                                   20


<210>  21250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21250
ccccaccuca auuguuucuu                                                   20


<210>  21251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21251
ucccccaaug aaugugggug                                                   20


<210>  21252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21252
cccaaugaau guggguggcc                                                   20


<210>  21253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21253
uugggggaag aaacaauuga                                                   20


<210>  21254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21254
ucugagucag acaaacaagu                                                   20


<210>  21255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21255
uccuugcaau acugccuccc                                                   20


<210>  21256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21256
uugcaauacu gccucccugg                                                   20


<210>  21257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21257
gaugucucau ugccaguuua                                                   20


<210>  21258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21258
acaaaugacu gugcaagaaa                                                   20


<210>  21259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21259
ugcacaguca uuuguugaaa                                                   20


<210>  21260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21260
uacacuacuu ugucucuuca                                                   20


<210>  21261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21261
aucaucaacu ugaccauccc                                                   20


<210>  21262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21262
ccucuuucuu cuuuucaaag                                                   20


<210>  21263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21263
ucuuuucaaa gccaugggga                                                   20


<210>  21264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21264
uuucaaagcc auggggagga                                                   20


<210>  21265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21265
aagccauggg gaggauaggg                                                   20


<210>  21266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21266
gagaugcccu ugcucuaugu                                                   20


<210>  21267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21267
cacugccacc acuccccgga                                                   20


<210>  21268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21268
uuucuuccuu uaggaagcag                                                   20


<210>  21269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21269
uccuuuagga agcagggacu                                                   20


<210>  21270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21270
uuuaggaagc agggacuugu                                                   20


<210>  21271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21271
uaaaggaaga aaagaauccg                                                   20


<210>  21272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21272
ucuggagaga cugcuagagg                                                   20


<210>  21273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21273
ucuagcaguc ucuccagagg                                                   20


<210>  21274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21274
ugacuuuccu cuagcagucu                                                   20


<210>  21275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21275
gcaaccccaa cucugccacu                                                   20


<210>  21276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21276
ugacuuugaa uaaauccuuu                                                   20


<210>  21277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21277
aagucacgaa acagcuggug                                                   20


<210>  21278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21278
uucuggcccu aaguguuucc                                                   20


<210>  21279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21279
ggcccuaagu guuuccaucu                                                   20


<210>  21280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21280
aucuuuaaaa ggagaagacu                                                   20


<210>  21281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21281
ccuuuuaaag auggaaacac                                                   20


<210>  21282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21282
cucuccugcc ucccaugcaa                                                   20


<210>  21283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21283
agcacggccu auaguagguc                                                   20


<210>  21284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21284
ccucaugacc uugaccugga                                                   20


<210>  21285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21285
gggcugggcu ugguccccag                                                   20


<210>  21286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21286
accuccuggg acacagucuu                                                   20


<210>  21287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21287
aggaggaaac cuaggugugu                                                   20


<210>  21288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21288
uccuugaagc ucagacaugu                                                   20


<210>  21289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21289
gucucauugg cucaggacac                                                   20


<210>  21290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21290
cugaccuuca gucucauugg                                                   20


<210>  21291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21291
ugguucucug accuucaguc                                                   20


<210>  21292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21292
uccugguucu cugaccuuca                                                   20


<210>  21293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21293
ccaaacccag gcuaaauguc                                                   20


<210>  21294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21294
cuugacauuu agccuggguu                                                   20


<210>  21295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21295
ggcaugagcc acugagaccu                                                   20


<210>  21296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21296
uagaguccug ugugugccuu                                                   20


<210>  21297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21297
uggaaagcca uguguaaaau                                                   20


<210>  21298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21298
aagaacccuc caugcugaug                                                   20


<210>  21299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21299
uuuuacacau ggcuuuccaa                                                   20


<210>  21300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21300
guaaaauaaa ucauauuugc                                                   20


<210>  21301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21301
gagauguuuc gucacccuuc                                                   20


<210>  21302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21302
ucacccuucc aggcucauug                                                   20


<210>  21303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21303
aggcucauug aaaauuggca                                                   20


<210>  21304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21304
augagccugg aagggugacg                                                   20


<210>  21305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21305
aacauuuuac cuuuuaagug                                                   20


<210>  21306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21306
uucccccaac ccccaauauc                                                   20


<210>  21307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21307
cccaaccccc aauauccucu                                                   20


<210>  21308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21308
gugggggagc ucacuauuua                                                   20


<210>  21309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21309
uuaaauagug agcuccccca                                                   20


<210>  21310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21310
ccacaggguu ucuuuaaaua                                                   20


<210>  21311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21311
aaagguuuca ccacaggguu                                                   20


<210>  21312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21312
guaaugugaa aaaucacucu                                                   20


<210>  21313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21313
cauuacagaa agauuguuaa                                                   20


<210>  21314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21314
auuaaugaga uuuuugugug                                                   20


<210>  21315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21315
gaaagugggg cucaacugca                                                   20


<210>  21316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21316
gaaggcccaa uacacacaaa                                                   20


<210>  21317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21317
aacuacaaag gcauggauug                                                   20


<210>  21318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21318
gggcaguguc uuuuaucguc                                                   20


<210>  21319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21319
gucacccgaa uuguccagcu                                                   20


<210>  21320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21320
ggugacagaa auauguucag                                                   20


<210>  21321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21321
cacaaacgua ucacaaacac                                                   20


<210>  21322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21322
cgaguggggc agggaggcau                                                   20


<210>  21323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21323
uuucucgagu ggggcaggga                                                   20


<210>  21324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21324
ucauuucucg aguggggcag                                                   20


<210>  21325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21325
cauccuuuuc uucauuucuc                                                   20


<210>  21326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21326
agguguccaa augaugauuu                                                   20


<210>  21327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21327
cccagguuaa guauuagaua                                                   20


<210>  21328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21328
ucagguaucu aauacuuaac                                                   20


<210>  21329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21329
ccuuccucag guaucuaaua                                                   20


<210>  21330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21330
acugagcauu caggaagagg                                                   20


<210>  21331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21331
ggaagaggca uggggcugug                                                   20


<210>  21332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21332
ugaaugcuca guugaaaaug                                                   20


<210>  21333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21333
cagccccaug ccucuuccug                                                   20


<210>  21334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21334
caucgcaucc aucuucacag                                                   20


<210>  21335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21335
gauaacaccu gccagagcag                                                   20


<210>  21336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21336
cugcucuggc agguguuauc                                                   20


<210>  21337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21337
gcuggcuuug auagacaagc                                                   20


<210>  21338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21338
gaguaauuug ggaguugugu                                                   20


<210>  21339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21339
aucggucuug agaaaauacu                                                   20


<210>  21340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21340
caagaccgau cgaaaugaua                                                   20


<210>  21341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21341
aguauuuucu caagaccgau                                                   20


<210>  21342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21342
uuagcuuauu cuaguauuuu                                                   20


<210>  21343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21343
ccuaaugcua ucccuccccu                                                   20


<210>  21344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21344
gcacauguau cccagaacuu                                                   20


<210>  21345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21345
gggauacaug ugcagaaugu                                                   20


<210>  21346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21346
uuauuuauuu uacucuaagu                                                   20


<210>  21347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21347
uucuuuauuu auuuuacucu                                                   20


<210>  21348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21348
uucuuucuuu auuuauuuua                                                   20


<210>  21349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21349
uucuuucuuu cuuuauuuau                                                   20


<210>  21350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21350
uucuuucuuu cuuucuuuau                                                   20


<210>  21351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21351
aagagacucc ugauguuuug                                                   20


<210>  21352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21352
ugggcacugu ggaaacaggg                                                   20


<210>  21353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21353
acagugccca cgaacaaaac                                                   20


<210>  21354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21354
ugacuuauca uccaagacug                                                   20


<210>  21355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21355
ccgugcacag accagucuug                                                   20


<210>  21356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21356
ggccccuucu ccgugcacag                                                   20


<210>  21357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21357
ucuggccccu ucuccgugca                                                   20


<210>  21358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21358
uggggcugcc uguucuucug                                                   20


<210>  21359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21359
uaaggaagca caucuguccu                                                   20


<210>  21360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21360
uuaagaaggg cuagaguugg                                                   20


<210>  21361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21361
auaaaggcca ggacagaugu                                                   20


<210>  21362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21362
agcaguccuc cugccucagc                                                   20


<210>  21363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21363
acccagccug ggcaacaugg                                                   20


<210>  21364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21364
ucccaaagua cucuccucac                                                   20


<210>  21365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21365
caaaguacuc uccucacauc                                                   20


<210>  21366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21366
acagggcgac uguuggggca                                                   20


<210>  21367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21367
cucauuccac agggcgacug                                                   20


<210>  21368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21368
ucacugggag gugaggcuaa                                                   20


<210>  21369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21369
aguuccucac ugggagguga                                                   20


<210>  21370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21370
gagaucuucg aguuccucac                                                   20


<210>  21371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21371
ggacccugcc caccuucuga                                                   20


<210>  21372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21372
gacaaacccc ucccacugcc                                                   20


<210>  21373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21373
gccgcggccc ugagguggca                                                   20


<210>  21374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21374
ggcaaucucc ucacuugccu                                                   20


<210>  21375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21375
ggcacuauug agugacuggu                                                   20


<210>  21376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21376
ggggaagcgu ggaaggcacu                                                   20


<210>  21377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21377
ccugaagucc acacaccagu                                                   20


<210>  21378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21378
acgcuucccc ugaaguccac                                                   20


<210>  21379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21379
caggccuaau acucugugac                                                   20


<210>  21380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21380
gagaaccaga acuggccauu                                                   20


<210>  21381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21381
cagaaucucu uggccaagac                                                   20


<210>  21382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21382
gguucucaga aucucuuggc                                                   20


<210>  21383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21383
ccagaauuaa aaccuauuau                                                   20


<210>  21384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21384
ggagaauggc caguucuggu                                                   20


<210>  21385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21385
gagcagcucu guguuaacca                                                   20


<210>  21386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21386
cauaauuucu gagcagcucu                                                   20


<210>  21387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21387
aagcucuacc aaaaaaaaug                                                   20


<210>  21388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21388
ucaggaauaa aacuaggcug                                                   20


<210>  21389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21389
ggaauaaaac uaggcugccc                                                   20


<210>  21390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21390
ugaagaaaug uuagagccug                                                   20


<210>  21391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21391
gccucaccuc aggcgagagg                                                   20


<210>  21392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21392
uucagccuca ccucaggcga                                                   20


<210>  21393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21393
uucagaaaac aggccucugc                                                   20


<210>  21394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21394
gaaaacaggc cucugcccgg                                                   20


<210>  21395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21395
gaaagaagga cuugccguca                                                   20


<210>  21396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21396
cugcagugcc ucagcaccuu                                                   20


<210>  21397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21397
cgccucccag gcacacagca                                                   20


<210>  21398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21398
gugggacuuu gccagagaga                                                   20


<210>  21399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21399
cuccucccug gcuuuuuacc                                                   20


<210>  21400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21400
uaauccuuca uuuauaccac                                                   20


<210>  21401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21401
uuuauaccac ugaccaaucu                                                   20


<210>  21402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21402
agauugguca gugguauaaa                                                   20


<210>  21403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21403
cugagcaaau uggagaugcc                                                   20


<210>  21404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21404
uggcucuacu aauucugcug                                                   20


<210>  21405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21405
gcugauucca uaugaguaac                                                   20


<210>  21406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21406
auaugaguaa cauccaaugu                                                   20


<210>  21407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21407
cagacaccuc caagcuccuc                                                   20


<210>  21408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21408
acuccuuucu acccaccuag                                                   20


<210>  21409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21409
acccaccuag cagguccacg                                                   20


<210>  21410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21410
caagcagucu uagagagacu                                                   20


<210>  21411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21411
acgcaguccc aaccaugagg                                                   20


<210>  21412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21412
uaguagaccu gagagagcuu                                                   20


<210>  21413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21413
uguuccuagu agaccugaga                                                   20


<210>  21414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21414
uuccuguucc uaguagaccu                                                   20


<210>  21415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21415
gccugagggg cuuguuaagg                                                   20


<210>  21416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21416
agggccucaa ccuucuacug                                                   20


<210>  21417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21417
acugcugggu agaaagcccc                                                   20


<210>  21418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21418
acccagcagu agaagguuga                                                   20


<210>  21419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21419
aagaggccga ccaggcaaga                                                   20


<210>  21420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21420
ugccuggucg gccucuuuga                                                   20


<210>  21421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21421
aggcaaagag ucaagggucu                                                   20


<210>  21422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21422
uuugauuuua uuuuauuuuc                                                   20


<210>  21423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21423
uacaaaaucu gaaaaugaaa                                                   20


<210>  21424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21424
gauuuuguaa gaaaauaaaa                                                   20


<210>  21425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21425
uuuucagauu uuguaagaaa                                                   20


<210>  21426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21426
gucccucccu uccaccaacc                                                   20


<210>  21427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21427
accaaccguu uuuugauuua                                                   20


<210>  21428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21428
uccuccccau aaaucaaaaa                                                   20


<210>  21429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21429
uuccuccucc ccauaaauca                                                   20


<210>  21430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21430
gauuucuuuc cuccucccca                                                   20


<210>  21431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21431
cacucaaaag cugcuuuugu                                                   20


<210>  21432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21432
ccgggaggag gccccacuga                                                   20


<210>  21433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21433
ccccuccucg cuguccuugg                                                   20


<210>  21434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21434
uguccccagc ccccuggccu                                                   20


<210>  21435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21435
gaaccuggcu cuccacucca                                                   20


<210>  21436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21436
gaagagagac auauccuuua                                                   20


<210>  21437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21437
ccuggaucca agucucccug                                                   20


<210>  21438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21438
ccaacuaaaa guucaaggcu                                                   20


<210>  21439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21439
aggcuucuaa gaaccaagac                                                   20


<210>  21440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21440
aagaaccaag acucaguggu                                                   20


<210>  21441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21441
uagaagccuu gaacuuuuag                                                   20


<210>  21442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21442
uugcccagca uggugcugga                                                   20


<210>  21443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21443
agcgcugugc agugaacuuu                                                   20


<210>  21444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21444
cugcacagcg cuugaauccu                                                   20


<210>  21445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21445
uccuguugga gagccauucu                                                   20


<210>  21446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21446
uguuggagag ccauucuaaa                                                   20


<210>  21447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21447
aaaugaccug gcuggaagga                                                   20


<210>  21448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21448
agccagguca uuuagaaugg                                                   20


<210>  21449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21449
ccuggucacu gcuggcucca                                                   20


<210>  21450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21450
cuaguaaaug auucacuaac                                                   20


<210>  21451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21451
cuaaccaagg agccucuggg                                                   20


<210>  21452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21452
aggggcugua auccucuccu                                                   20


<210>  21453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21453
cuguacuauu uuggcaaucu                                                   20


<210>  21454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21454
cuuuccaaau gcuguguaau                                                   20


<210>  21455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21455
aaaugcugug uaauuacaca                                                   20


<210>  21456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21456
uuaagucuuc uggugaauug                                                   20


<210>  21457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21457
ggugaauugg ucucaauuac                                                   20


<210>  21458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21458
ccagaagacu uaaggaaauu                                                   20


<210>  21459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21459
uccuuccucu cucaauuugu                                                   20


<210>  21460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21460
uuccucucuc aauuuguuuu                                                   20


<210>  21461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21461
ucucucaauu uguuuuagca                                                   20


<210>  21462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21462
ucuauucuca uccccuaccu                                                   20


<210>  21463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21463
cauccccuac cugcaccccc                                                   20


<210>  21464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21464
cuugggacag agaugggggu                                                   20


<210>  21465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21465
uucucuuggg acagagaugg                                                   20


<210>  21466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21466
cacuguucuu ucucuuggga                                                   20


<210>  21467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21467
agcggaggua cuucacacug                                                   20


<210>  21468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21468
aaaauaggau uauucaagcg                                                   20


<210>  21469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21469
aaauaguuuu ugcuccacua                                                   20


<210>  21470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21470
uagccuuauu uuuaagcccu                                                   20


<210>  21471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21471
agccagccug uaaugccccu                                                   20


<210>  21472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21472
cccugcaucu gaggcaggga                                                   20


<210>  21473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21473
cugagcugcg gccaccacug                                                   20


<210>  21474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21474
ucccugagcu gcggccacca                                                   20


<210>  21475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21475
uucuucccug agcugcggcc                                                   20


<210>  21476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21476
cagccccaaa acugggaagg                                                   20


<210>  21477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21477
caguuuuggg gcugggaagc                                                   20


<210>  21478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21478
agggcccuuc ccaguuuugg                                                   20


<210>  21479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21479
caaaccuagc cacccaucuc                                                   20


<210>  21480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21480
agcauguccc aagcagagau                                                   20


<210>  21481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21481
ugccuuccag caugucccaa                                                   20


<210>  21482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21482
cucuucuugc cuuccagcau                                                   20


<210>  21483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21483
aggaguuacu uguuucucuc                                                   20


<210>  21484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21484
uuuuuguuuu caaggaguua                                                   20


<210>  21485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21485
uaggaucccu gcuucauuuu                                                   20


<210>  21486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21486
gaacccaggg ccuucucucu                                                   20


<210>  21487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21487
gaauguuuuu acuuuuccua                                                   20


<210>  21488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21488
cucugucucc cacgaccuac                                                   20


<210>  21489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21489
caccucugcu uugcggcuuu                                                   20


<210>  21490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21490
agcccugggu gacccucuga                                                   20


<210>  21491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21491
ccugccagcu ugugggcugg                                                   20


<210>  21492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21492
gcugcaguug cucuuagcca                                                   20


<210>  21493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21493
ucuccauuuc cauggcucgu                                                   20


<210>  21494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21494
ccauuuccau ggcucgugaa                                                   20


<210>  21495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21495
auggcucgug aauuuuuuug                                                   20


<210>  21496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21496
cgagccaugg aaauggagaa                                                   20


<210>  21497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21497
ugacgcucca cccccuacau                                                   20


<210>  21498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21498
uuuccccaca ugcuccagca                                                   20


<210>  21499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21499
ccacaugcuc cagcacauac                                                   20


<210>  21500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21500
acaagugaga uuaauuuucu                                                   20


<210>  21501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21501
aacagaaccc uaguacauuc                                                   20


<210>  21502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21502
guuagaaaau uaaucucacu                                                   20


<210>  21503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21503
gugugauggu gggagagccu                                                   20


<210>  21504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21504
aggacacugu gauggucaaa                                                   20


<210>  21505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21505
cagagagcau gcugagcuca                                                   20


<210>  21506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21506
cuucccagag agcaugcuga                                                   20


<210>  21507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21507
caauucacuu cccagagagc                                                   20


<210>  21508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21508
cuuucccaau ucacuuccca                                                   20


<210>  21509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21509
ccauucacuu ucccaauuca                                                   20


<210>  21510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21510
auggggcugu cuguguguug                                                   20


<210>  21511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21511
ccagcucagg aaacccaccu                                                   20


<210>  21512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21512
ugagcuggag aauuuuccau                                                   20


<210>  21513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21513
ccggaaccuc uggucuguuc                                                   20


<210>  21514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21514
ggagaagguc ucuauaccua                                                   20


<210>  21515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21515
aguccugcug ucaaaagaaa                                                   20


<210>  21516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21516
uuugacagca ggacuagaac                                                   20


<210>  21517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21517
caguggaggg cuuguuuguc                                                   20


<210>  21518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21518
ucaaggucac uucugacucc                                                   20


<210>  21519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21519
gacucccagg aagagaggca                                                   20


<210>  21520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21520
ugggagucag aagugaccuu                                                   20


<210>  21521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21521
aucuugagag uuuaguuugg                                                   20


<210>  21522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21522
gguugugguu ucucuuccuc                                                   20


<210>  21523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21523
cuuccuccau uaaaaaaaaa                                                   20


<210>  21524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21524
uccauuaaaa aaaaaaauug                                                   20


<210>  21525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21525
guuuccuguu cacggagcgg                                                   20


<210>  21526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21526
uguucacgga gcggacagaa                                                   20


<210>  21527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21527
cggagcggac agaaggaggg                                                   20


<210>  21528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21528
guccgcuccg ugaacaggaa                                                   20


<210>  21529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21529
cggcucugcu ccauguauca                                                   20


<210>  21530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21530
ggauauucuc ggcucugcuc                                                   20


<210>  21531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21531
ccaguuccgg auauucucgg                                                   20


<210>  21532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21532
cacuuuucuc caguuccgga                                                   20


<210>  21533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21533
uggcuuccaa acaguuguaa                                                   20


<210>  21534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21534
aaacaguugu aauuuccacu                                                   20


<210>  21535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21535
acugccacug cuuaguuccu                                                   20


<210>  21536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21536
ugggcaccag gcauacagag                                                   20


<210>  21537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21537
cacucuguau gccuggugcc                                                   20


<210>  21538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21538
uguggauuua aaugccaaau                                                   20


<210>  21539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21539
ugcuuccugu ggauuuaaau                                                   20


<210>  21540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21540
ucuugcuucc uguggauuua                                                   20


<210>  21541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21541
ucugcaaauc uauaaauaag                                                   20


<210>  21542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21542
cgcguaugug aaggagcaau                                                   20


<210>  21543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21543
cauacgcgag aagugcauuu                                                   20


<210>  21544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21544
auuuucagac uuggaaaguu                                                   20


<210>  21545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21545
gacuuggaaa guucuccaua                                                   20


<210>  21546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21546
aagucugaaa auggaauugc                                                   20


<210>  21547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21547
ccauaauuaa guaucaccca                                                   20


<210>  21548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21548
ggguugggug auacuuaauu                                                   20


<210>  21549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21549
ugaaaacagg gcagaagacu                                                   20


<210>  21550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21550
ggaagcugau cuuaaccuug                                                   20


<210>  21551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21551
gcccuguuuu caggaagcug                                                   20


<210>  21552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21552
gugguagcuc aaaaauucua                                                   20


<210>  21553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21553
auuuugaagg acagguuagu                                                   20


<210>  21554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21554
aaauagaauu uuugagcuac                                                   20


<210>  21555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21555
guucauguga uuauacagug                                                   20


<210>  21556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21556
ugugauuaua cagugccuug                                                   20


<210>  21557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21557
agaaugugua aucaucucuu                                                   20


<210>  21558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21558
agaaagcaag gcacuguaua                                                   20


<210>  21559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21559
gaugacauuu uaaauaucca                                                   20


<210>  21560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21560
agcuugacuc ugcuaucaau                                                   20


<210>  21561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21561
guggggacuc ugccaaucaa                                                   20


<210>  21562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21562
uucaaacauu acagaaauga                                                   20


<210>  21563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21563
aacauuacag aaaugaugau                                                   20


<210>  21564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21564
guaauguuug aaagaaagau                                                   20


<210>  21565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21565
ugcagugccu uuaucaguaa                                                   20


<210>  21566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21566
gcccaugauu acuuugcgag                                                   20


<210>  21567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21567
caaacaucuc gcaaaguaau                                                   20


<210>  21568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21568
ucucaaacau cucgcaaagu                                                   20


<210>  21569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21569
caugaauaac ugcaaggaua                                                   20


<210>  21570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21570
ugggaaauaa uauaaaucac                                                   20


<210>  21571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21571
ccuccaacua cccacacuau                                                   20


<210>  21572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21572
cucgccugug uugauucucc                                                   20


<210>  21573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21573
ugaacaaugc uagccaacaa                                                   20


<210>  21574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21574
ggaaguguag cauuaaggag                                                   20


<210>  21575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21575
ccucuaauau auaucccgug                                                   20


<210>  21576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21576
cuaccacggg auauauauua                                                   20


<210>  21577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21577
ccuugucaag accauuucuc                                                   20


<210>  21578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21578
uggucuuccc cuugucaaga                                                   20


<210>  21579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21579
uuuccugguc uuccccuugu                                                   20


<210>  21580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21580
ggccuuugaa aagugguuua                                                   20


<210>  21581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21581
aaggccugaa uggagcugau                                                   20


<210>  21582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21582
ccugcccagu gcaaagaucc                                                   20


<210>  21583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21583
gaccuuggcc agggaucuuu                                                   20


<210>  21584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21584
cuguccaagg cagaacccaa                                                   20


<210>  21585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21585
gccuuggaca gagaaacaga                                                   20


<210>  21586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21586
acaacucaga cccuguggaa                                                   20


<210>  21587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21587
acagggucug aguuguugaa                                                   20


<210>  21588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21588
gacaacugca gcauuccaca                                                   20


<210>  21589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21589
uggggacgag cauccucucu                                                   20


<210>  21590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21590
uuugauguuu ccuggggacg                                                   20


<210>  21591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21591
uuacuguaau ccacgucugc                                                   20


<210>  21592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21592
guuuuagauu uuccuuacug                                                   20


<210>  21593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21593
gcagacaaca aaggaagaau                                                   20


<210>  21594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21594
uuuguugucu gcugaagcau                                                   20


<210>  21595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21595
uccuuuguug ucugcugaag                                                   20


<210>  21596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21596
agugcuuugg gcgagugcuu                                                   20


<210>  21597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21597
uuuuauuuuu cuuuccuauu                                                   20


<210>  21598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21598
uuccuauuuu uguucuucug                                                   20


<210>  21599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21599
uauuuuuguu cuucugguug                                                   20


<210>  21600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21600
ucugguuguu cuuucuuucu                                                   20


<210>  21601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21601
gguuguucuu ucuuucuucc                                                   20


<210>  21602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21602
uucuuucuuc cuuuucuccc                                                   20


<210>  21603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21603
uucuuccuuu ucucccuuuu                                                   20


<210>  21604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21604
uccuuuucuc ccuuuuuuuc                                                   20


<210>  21605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21605
uuuucucccu uuuuuucuuu                                                   20


<210>  21606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21606
cccuuuuuuu cuuuccuucu                                                   20


<210>  21607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21607
uuccuucuuu uucuuucuug                                                   20


<210>  21608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21608
uucuuuuucu uucuugguug                                                   20


<210>  21609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21609
uuuucuuucu ugguugcuuu                                                   20


<210>  21610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21610
uucuugguug cuuuuuuuuc                                                   20


<210>  21611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21611
ugguugcuuu uuuuuccccc                                                   20


<210>  21612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21612
cccuuugaaa cugaaccauu                                                   20


<210>  21613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21613
aagggggaaa aaaaagcaac                                                   20


<210>  21614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21614
guuucaaagg gggaaaaaaa                                                   20


<210>  21615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21615
guuaaaaauc agaagcuugu                                                   20


<210>  21616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21616
gauuuuuaac agaagcuaug                                                   20


<210>  21617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21617
acaagacccc ucauacgcgg                                                   20


<210>  21618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21618
aauuaacaga ggagcucuaa                                                   20


<210>  21619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21619
gcaaaugcag gucacuaucg                                                   20


<210>  21620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21620
ucugugacag uuguuggguu                                                   20


<210>  21621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21621
aggagcuggc aggguugucc                                                   20


<210>  21622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21622
gacacuguca gagucuggac                                                   20


<210>  21623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21623
caggaaguua cacgcaaggu                                                   20


<210>  21624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21624
ugugaagcag ccguggugac                                                   20


<210>  21625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21625
cuguagccca gaagccugau                                                   20


<210>  21626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21626
gggcuacagg gaaacugacu                                                   20


<210>  21627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21627
ucaggcuucu gggcuacagg                                                   20


<210>  21628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21628
gcugaaaaua gcucgaauuc                                                   20


<210>  21629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21629
gcugaaugug agugcagauu                                                   20


<210>  21630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21630
agcuauuuuc agcugaaugu                                                   20


<210>  21631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21631
aacccucucu cccccugccu                                                   20


<210>  21632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21632
ccuuuuccuc cuuucuacuu                                                   20


<210>  21633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21633
uccuuucuac uuccuugccu                                                   20


<210>  21634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21634
acuuccuugc cucucuuucu                                                   20


<210>  21635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21635
uugccucucu uucuccaacc                                                   20


<210>  21636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21636
ccaaccucug uuuccagcau                                                   20


<210>  21637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21637
agcaucuucu uucucaucuu                                                   20


<210>  21638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21638
uucucaucuu cucucucuuu                                                   20


<210>  21639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21639
caucuucucu cucuuuaguc                                                   20


<210>  21640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21640
cucucuuuag uccucaacaa                                                   20


<210>  21641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21641
ccagaaaggg aaguagguuu                                                   20


<210>  21642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21642
ggugaaugug gcuguuuuug                                                   20


<210>  21643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21643
cuuucuggug aauguggcug                                                   20


<210>  21644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21644
cugaaacagc agugauugug                                                   20


<210>  21645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21645
gugaaaagca acccgguuua                                                   20


<210>  21646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21646
acaaucacug cuguuucagu                                                   20


<210>  21647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21647
guuccacaau cacugcuguu                                                   20


<210>  21648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21648
uauuuuuuug caccggucag                                                   20


<210>  21649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21649
aacauggcuc acguguuuuu                                                   20


<210>  21650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21650
uaagagaagg gggaauuugg                                                   20


<210>  21651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21651
cuuaagaaaa aacacgugag                                                   20


<210>  21652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21652
cccuucucuu aagaaaaaac                                                   20


<210>  21653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21653
uuuuuugccc cccuccaaau                                                   20


<210>  21654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21654
ccuucuuuuu uugccccccu                                                   20


<210>  21655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21655
ucucuuucuc cuucuuuuuu                                                   20


<210>  21656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21656
cgagugguua accuuuccuc                                                   20


<210>  21657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21657
ugcccuuauc accauuccag                                                   20


<210>  21658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21658
aguauaaaac cucaaauuau                                                   20


<210>  21659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21659
cauaauuuga gguuuuauac                                                   20


<210>  21660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21660
cacuuaggaa caccucauua                                                   20


<210>  21661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21661
uaagugagaa uucccauaau                                                   20


<210>  21662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21662
auaaugaggu guuccuaagu                                                   20


<210>  21663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21663
cccaucuccc cagaccccca                                                   20


<210>  21664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21664
ugaccaugug uguaaacuug                                                   20


<210>  21665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21665
agccaaaaag aaauccucug                                                   20


<210>  21666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21666
uuuuggcuug aacuugauaa                                                   20


<210>  21667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21667
uauuuugauu uaaauacugu                                                   20


<210>  21668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21668
aaggcuaugc cuugguggug                                                   20


<210>  21669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21669
uccaaggcua ugccuuggug                                                   20


<210>  21670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21670
caaguugacc uuuucaccag                                                   20


<210>  21671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21671
ccaggccagu gccuaauuuc                                                   20


<210>  21672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21672
uaaacaggcc ccuucuuccu                                                   20


<210>  21673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21673
uccuugaagu cacugcaaau                                                   20


<210>  21674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21674
uugaagucac ugcaaauaaa                                                   20


<210>  21675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21675
aggaagaagg ggccuguuua                                                   20


<210>  21676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21676
auuacacucu ggaugacugc                                                   20


<210>  21677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21677
uaagccagua acuccaaggc                                                   20


<210>  21678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21678
gucugggcua uggccucuca                                                   20


<210>  21679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21679
ugcuggagug gccuugcucc                                                   20


<210>  21680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21680
uucuuggcua gcagaugcua                                                   20


<210>  21681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21681
uggcuagcag augcuagucc                                                   20


<210>  21682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21682
ugggacuagc aucugcuagc                                                   20


<210>  21683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21683
guuuuugcag uuagcuuaaa                                                   20


<210>  21684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21684
accuauaagg gaaaaauaaa                                                   20


<210>  21685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21685
cuuauaggua gaauauaaaa                                                   20


<210>  21686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21686
aggucuaggu uuauuuuucc                                                   20


<210>  21687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21687
uuuuaaauga guugauuggc                                                   20


<210>  21688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21688
ugacguugga uggaggguuu                                                   20


<210>  21689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21689
gcagcuucgu gacguuggau                                                   20


<210>  21690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21690
ugggaagcug ucccagcaac                                                   20


<210>  21691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21691
caggaaccua auauucagca                                                   20


<210>  21692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21692
cauaucuagg uugcugggac                                                   20


<210>  21693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21693
ggggugagaa gugaaguugc                                                   20


<210>  21694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21694
caccccagaa uagcaagcgu                                                   20


<210>  21695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21695
cuucucaccc cagaauagca                                                   20


<210>  21696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21696
cucgggacug ucaaacacag                                                   20


<210>  21697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21697
caaggggcau ugcugguauu                                                   20


<210>  21698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21698
cuggguugag cucagcccgu                                                   20


<210>  21699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21699
caaaggucac acagcaauuc                                                   20


<210>  21700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21700
agguccccca gaaguagccc                                                   20


<210>  21701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21701
gggggaccug gaauugcugu                                                   20


<210>  21702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21702
ccagauggau cccaucacca                                                   20


<210>  21703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21703
aagagcuauc uggugauggg                                                   20


<210>  21704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21704
cauuuucaac aagaaggcug                                                   20


<210>  21705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21705
acaagaaggc ugaggaauga                                                   20


<210>  21706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21706
uguugaaaau gagaaucaga                                                   20


<210>  21707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21707
ucagccuucu uguugaaaau                                                   20


<210>  21708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21708
uuccccaacu uucuuucucc                                                   20


<210>  21709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21709
ccaacuuucu uucuccaacc                                                   20


<210>  21710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21710
uucuccaacc uucugcucug                                                   20


<210>  21711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21711
ccaaccuucu gcucugguuc                                                   20


<210>  21712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21712
gcucugguuc uccucucccc                                                   20


<210>  21713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21713
ccucuccccc accacacgua                                                   20


<210>  21714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21714
auaucuaccc aaaaucucca                                                   20


<210>  21715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21715
aucagcaggu caagaguaga                                                   20


<210>  21716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21716
cuacucuuga ccugcugaua                                                   20


<210>  21717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21717
ccauucugaa auggauuuga                                                   20


<210>  21718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21718
gaaauggauu ugacugaaca                                                   20


<210>  21719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21719
gaauggagaa cagcuuguca                                                   20


<210>  21720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21720
gucaaaucca uuucagaaug                                                   20


<210>  21721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21721
gcagcuguuc agucaaaucc                                                   20


<210>  21722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21722
ggguccuugu ucugugggug                                                   20


<210>  21723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21723
guggguggac cauggcuccu                                                   20


<210>  21724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21724
agagaaugac uugugauuug                                                   20


<210>  21725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21725
cuggaaagga gccauggucc                                                   20


<210>  21726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21726
cucuccuaca caucaaagug                                                   20


<210>  21727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21727
cacacaauga gaaagaacgg                                                   20


<210>  21728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21728
cauuguguga gaaggaggca                                                   20


<210>  21729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21729
uucucauugu gugagaagga                                                   20


<210>  21730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21730
aagaguucac uuucugcaca                                                   20


<210>  21731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21731
cuuucugcac auauguguag                                                   20


<210>  21732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21732
gcacauaugu guaguuaagu                                                   20


<210>  21733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21733
guacuuaacu acacauaugu                                                   20


<210>  21734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21734
cacuucagua cuuaacuaca                                                   20


<210>  21735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21735
agaaaacuau acuuaggcac                                                   20


<210>  21736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21736
ugaauuucuc acuucaguac                                                   20


<210>  21737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21737
aaagaccuac caaucuaaga                                                   20


<210>  21738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21738
guaucuuaga uugguagguc                                                   20


<210>  21739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21739
uucaguaucu uagauuggua                                                   20


<210>  21740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21740
gggccugaug uagccauuuu                                                   20


<210>  21741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21741
aggcuuuucu gggccugaug                                                   20


<210>  21742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21742
cuauccacag accacagccc                                                   20


<210>  21743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21743
ucucaaagcc agaggaucuc                                                   20


<210>  21744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21744
gugcauuauu caucucaaag                                                   20


<210>  21745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21745
caugucuggu aauaaucugc                                                   20


<210>  21746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21746
ggcccaaucc ugauguugag                                                   20


<210>  21747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21747
cucaggaagg ccuugauagc                                                   20


<210>  21748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21748
ugagagaagu uucaggccca                                                   20


<210>  21749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21749
cagacugugg gcucagacuc                                                   20


<210>  21750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21750
cagggagacg uucccacuca                                                   20


<210>  21751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21751
cacucaacac ccugggaaga                                                   20


<210>  21752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21752
caggguguug agugggaacg                                                   20


<210>  21753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21753
caguagucuu cccagggugu                                                   20


<210>  21754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21754
uguauuugcc cuuuucccug                                                   20


<210>  21755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21755
cugcuaacag aaauggaauc                                                   20


<210>  21756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21756
guuagcaggg aaaagggcaa                                                   20


<210>  21757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21757
auuucuguua gcagggaaaa                                                   20


<210>  21758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21758
gauuccauuu cuguuagcag                                                   20


<210>  21759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21759
aucagaauaa aaaagacucg                                                   20


<210>  21760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21760
gauagaauag uaaucuuaaa                                                   20


<210>  21761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21761
aagcgaaggc aaaugccccu                                                   20


<210>  21762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21762
cuuugaaucu cccgagucuu                                                   20


<210>  21763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21763
ggcauuuagg agcgcuagac                                                   20


<210>  21764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21764
cugccuccaa ccugugauuu                                                   20


<210>  21765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21765
ugccuugugg caaaucacag                                                   20


<210>  21766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21766
ccuuccugcc uuguggcaaa                                                   20


<210>  21767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21767
cacacuuagg gguguugcac                                                   20


<210>  21768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21768
aaccuuuuac ccauguaaug                                                   20


<210>  21769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21769
uugauuaaag gcaaaauauu                                                   20


<210>  21770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21770
ugcuaauguc agcagagccc                                                   20


<210>  21771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21771
ggugucugca ccccacaaug                                                   20


<210>  21772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21772
acucucggug uguggcauug                                                   20


<210>  21773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21773
uuuuccacuc ucggugugug                                                   20


<210>  21774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21774
gcagggggag caguguagug                                                   20


<210>  21775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21775
ucaucuguau ggaaauuggg                                                   20


<210>  21776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21776
auacagauga cgaaaacgua                                                   20


<210>  21777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21777
caauuuccau acagaugacg                                                   20


<210>  21778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21778
caaauguaga uuaucuuccc                                                   20


<210>  21779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21779
cuugggaucc uucuggaggg                                                   20


<210>  21780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21780
ggagggcuau aaauaauaga                                                   20


<210>  21781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21781
auuauuuaua gcccuccaga                                                   20


<210>  21782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21782
uuuuuaaaua ucuaauguug                                                   20


<210>  21783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21783
gauuaaggga aaacuaaaug                                                   20


<210>  21784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21784
cuuaaucuga aucuguauuc                                                   20


<210>  21785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21785
ggauuuuaua aaggcaucau                                                   20


<210>  21786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21786
ugccuuuuuu uguuuuguuu                                                   20


<210>  21787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21787
uuuucaugcc uuuuuuuguu                                                   20


<210>  21788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21788
cuggcaacca caccagccuu                                                   20


<210>  21789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21789
aaguaaccau uucccacucc                                                   20


<210>  21790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21790
cacucccuua uuuaugagca                                                   20


<210>  21791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21791
gcugcucaua aauaagggag                                                   20


<210>  21792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21792
caucaaccau ucuaucuaag                                                   20


<210>  21793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21793
aucuaaggaa gcugcagaaa                                                   20


<210>  21794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21794
uuagauagaa ugguugauga                                                   20


<210>  21795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21795
gcagcuuccu uagauagaau                                                   20


<210>  21796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21796
ccuuucugca gcuuccuuag                                                   20


<210>  21797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21797
aguuuucacc uuucugcagc                                                   20


<210>  21798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21798
uaaauuucca guuuucaccu                                                   20


<210>  21799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21799
cauuaaaggu ucauaaauuu                                                   20


<210>  21800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21800
uauccagauu ucccauuaaa                                                   20


<210>  21801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21801
uauauuuaga ccaaauucuu                                                   20


<210>  21802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21802
ucuucauaua uuuagaccaa                                                   20


<210>  21803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21803
caacucuaga auggagcccu                                                   20


<210>  21804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21804
agaguuggga aaaccaaguc                                                   20


<210>  21805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21805
ccagguuuag augagggcuc                                                   20


<210>  21806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21806
uauauugcuu ccccagguuu                                                   20


<210>  21807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21807
cauuauguag aaacauuuaa                                                   20


<210>  21808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21808
acauaaugag aauaaauugu                                                   20


<210>  21809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21809
aggauaauuu aaauguuucu                                                   20


<210>  21810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21810
aagaguguuu cuuccuuucc                                                   20


<210>  21811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21811
uccuuuccuu cuaggaacau                                                   20


<210>  21812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21812
uuuccuucua ggaacaugag                                                   20


<210>  21813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21813
uucuaggaac augaggagug                                                   20


<210>  21814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21814
aggaacauga ggagugaauc                                                   20


<210>  21815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21815
uagaaggaaa ggaagaaaca                                                   20


<210>  21816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21816
cuccucaugu uccuagaagg                                                   20


<210>  21817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21817
ucaaagccug uaaaagauac                                                   20


<210>  21818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21818
guuaaaauca ugacucaggu                                                   20


<210>  21819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21819
uggagacauu guucaguuaa                                                   20


<210>  21820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21820
gacugugaga gggggaagaa                                                   20


<210>  21821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21821
cccucucaca gucugaauuc                                                   20


<210>  21822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21822
ucccccucuc acagucugaa                                                   20


<210>  21823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21823
cacugcacca aagagacggu                                                   20


<210>  21824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21824
ucuccucugu ccuuggcaau                                                   20


<210>  21825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21825
cauuugcugu aauccuguua                                                   20


<210>  21826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21826
uucacauuug cuguaauccu                                                   20


<210>  21827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21827
uuuuuugcug acacagaacu                                                   20


<210>  21828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21828
gugucagcaa aaaaugaaac                                                   20


<210>  21829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21829
cuggaaaccc uguuauggcu                                                   20


<210>  21830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21830
agugaauugu auaaguagca                                                   20


<210>  21831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21831
cccaaugaaa gaaaauacuu                                                   20


<210>  21832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21832
uugggggaag caaacuauuu                                                   20


<210>  21833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21833
uucauugggg gaagcaaacu                                                   20


<210>  21834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21834
ccugcaguac aguaaguauu                                                   20


<210>  21835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21835
guaaaacuuu cuaguuuugc                                                   20


<210>  21836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21836
aguuuugcuu aacaugaaaa                                                   20


<210>  21837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21837
uguuaagcaa aacuagaaag                                                   20


<210>  21838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21838
aaucaguauc aauagccaaa                                                   20


<210>  21839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21839
gagguggagu uucgcucuug                                                   20


<210>  21840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21840
cucuuguugc ccgggcugga                                                   20


<210>  21841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21841
agcgauucuc cugccucagc                                                   20


<210>  21842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21842
ccugccucag ccucccaagu                                                   20


<210>  21843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21843
guauuuuugg uagagacggg                                                   20


<210>  21844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21844
ccauguuggu caggcugguc                                                   20


<210>  21845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21845
aagaaaaaaa augcugugug                                                   20


<210>  21846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21846
uugaagauaa auuuguuuug                                                   20


<210>  21847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21847
aaaggguacc uuagacccca                                                   20


<210>  21848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21848
ccaaacucua aagcaacagu                                                   20


<210>  21849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21849
acuuuauuuu ccccaaacuc                                                   20


<210>  21850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21850
cacugugaga gccagucaac                                                   20


<210>  21851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21851
cauuccauuu cuuuuauguc                                                   20


<210>  21852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21852
auuucuuuua ugucauuuug                                                   20


<210>  21853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21853
uuuaugucau uuugcccaca                                                   20


<210>  21854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21854
uacaauagag gcauuuggaa                                                   20


<210>  21855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21855
aaaugccucu auuguaugaa                                                   20


<210>  21856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21856
uaacuaauuu cugccgcugg                                                   20


<210>  21857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21857
gccgcuggaa guuuguuccu                                                   20


<210>  21858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21858
agcggcagaa auuaguuagg                                                   20


<210>  21859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21859
uaaagccacc aagucuccua                                                   20


<210>  21860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21860
aggagacuug guggcuuuag                                                   20


<210>  21861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21861
uggcaguaaa cacacggcgg                                                   20


<210>  21862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21862
uuugagauag gugcugguca                                                   20


<210>  21863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21863
gaguagaaga ggaagcaccu                                                   20


<210>  21864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21864
acucagaauu uucuuuugag                                                   20


<210>  21865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21865
ucuucuacuc agaauuuucu                                                   20


<210>  21866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21866
ggugcuuccu cuucuacuca                                                   20


<210>  21867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21867
uucaggugcu uccucuucua                                                   20


<210>  21868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21868
gcuuccuuca ggugcuuccu                                                   20


<210>  21869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21869
uuucagcuuc cuucaggugc                                                   20


<210>  21870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21870
aaugucagac uuucuuuuca                                                   20


<210>  21871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21871
aacagagguu cuuuccccuc                                                   20


<210>  21872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21872
uuccccucua ggacacucug                                                   20


<210>  21873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21873
ccucuaggac acucuggguc                                                   20


<210>  21874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21874
uuguucccug gcucaucucc                                                   20


<210>  21875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21875
cuggcucauc uccugagccc                                                   20


<210>  21876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21876
ccuuuccaac ugucuauuua                                                   20


<210>  21877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21877
aacugucuau uuacuaacca                                                   20


<210>  21878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21878
ggcuagcuua auaaccccca                                                   20


<210>  21879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21879
uaucccugug aucucucuuu                                                   20


<210>  21880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21880
ugauagcauu uaucauuuug                                                   20


<210>  21881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21881
gaacgucauu ccugcccacu                                                   20


<210>  21882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21882
gaaucaaggg cccaucaggg                                                   20


<210>  21883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21883
ugcccacucc ccaucugcaa                                                   20


<210>  21884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21884
uuuugccuuu gcccccauug                                                   20


<210>  21885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21885
aagauuuaaa caguccucua                                                   20


<210>  21886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21886
auucugcuag ugaaaggaaa                                                   20


<210>  21887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21887
gcuagugaaa ggaaacccua                                                   20


<210>  21888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21888
cuagcagaau ggaaccagau                                                   20


<210>  21889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21889
uuucacuagc agaauggaac                                                   20


<210>  21890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21890
agaggaugga guugguugac                                                   20


<210>  21891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21891
ccccuguuga cuuauauguu                                                   20


<210>  21892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21892
ugccgaguuc uccccuguug                                                   20


<210>  21893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21893
cuguuauacc cuucaugccg                                                   20


<210>  21894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21894
acaacucauc cacccccuuu                                                   20


<210>  21895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21895
gaucagagua uuucagcagc                                                   20


<210>  21896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21896
gcagcccucu gugaucuaua                                                   20


<210>  21897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21897
agagcuccac aauccaacuc                                                   20


<210>  21898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21898
auuccagucu uaguuccccg                                                   20


<210>  21899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21899
agucuuaguu ccccguaccc                                                   20


<210>  21900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21900
ccguacccau caaggaaaau                                                   20


<210>  21901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21901
uugaugggua cggggaacua                                                   20


<210>  21902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21902
gcccaaguaa aaaucccuuc                                                   20


<210>  21903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21903
guucucauuu ccuuccuggc                                                   20


<210>  21904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21904
cauuuccuuc cuggcuuuuc                                                   20


<210>  21905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21905
uuccuggcuu uucuucuucu                                                   20


<210>  21906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21906
uggcuuuucu ucuucuucuc                                                   20


<210>  21907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21907
ucuucuucuc uuaccuccug                                                   20


<210>  21908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21908
ucuucucuua ccuccuggaa                                                   20


<210>  21909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21909
ucucuuaccu ccuggaaucc                                                   20


<210>  21910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21910
cuuaccuccu ggaauccugc                                                   20


<210>  21911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21911
aggagguaag agaagaagaa                                                   20


<210>  21912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21912
aggccucaau gaaggucuac                                                   20


<210>  21913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21913
uugaggccuu gaaguaugag                                                   20


<210>  21914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21914
ugcuaaggug acuagguaga                                                   20


<210>  21915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21915
ucuugcuaag gugacuaggu                                                   20


<210>  21916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21916
ccaaccucau agaacacuca                                                   20


<210>  21917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21917
augagguugg agaaggauga                                                   20


<210>  21918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21918
uguguuccca augaguuucu                                                   20


<210>  21919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21919
caaugaguuu cuucaauaca                                                   20


<210>  21920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21920
ucaauacagg gacucuuucu                                                   20


<210>  21921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21921
auacagggac ucuuucuccu                                                   20


<210>  21922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21922
ccuacuugcu ucuauuauau                                                   20


<210>  21923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21923
auuauauuug aaaguaccag                                                   20


<210>  21924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21924
aauauaauag aagcaaguag                                                   20


<210>  21925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21925
uauauucuag gaauucaaca                                                   20


<210>  21926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21926
aggaauucaa caaauagcau                                                   20


<210>  21927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21927
uagaauauau gaauaucaug                                                   20


<210>  21928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21928
acaaauagca uauaaaugac                                                   20


<210>  21929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21929
uaaaagggaa guuauuuuuc                                                   20


<210>  21930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21930
cuuuuaggaa gguaaaucag                                                   20


<210>  21931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21931
aaauaucauu ucuguucaaa                                                   20


<210>  21932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21932
guucaaaaug guaauuuuaa                                                   20


<210>  21933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21933
aaaugguaau uuuaaccuuc                                                   20


<210>  21934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21934
uagcacccac aaacauuucc                                                   20


<210>  21935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21935
cuucugauau cuacuugaac                                                   20


<210>  21936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21936
gauaucuacu ugaacuuuca                                                   20


<210>  21937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21937
aguagauauc agaagggaaa                                                   20


<210>  21938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21938
gauaaaaaaa aaaaagcaag                                                   20


<210>  21939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21939
ugcuaaucuu uguguagcau                                                   20


<210>  21940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21940
ccagggugug ggguggcugu                                                   20


<210>  21941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21941
cauuugcucu ucuccagggu                                                   20


<210>  21942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21942
auaugugaag cccaacuacg                                                   20


<210>  21943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21943
cauauagaag auguugucau                                                   20


<210>  21944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21944
accaugguca ucugcaaaga                                                   20


<210>  21945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21945
uugcagauga ccaugguuga                                                   20


<210>  21946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21946
aaaaacguau ucuuaaugcu                                                   20


<210>  21947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21947
uaaugcuguu uuaaaugcag                                                   20


<210>  21948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21948
gcuauuaagu acaguaaaag                                                   20


<210>  21949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21949
uuuuacugua cuuaauagcu                                                   20


<210>  21950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21950
aaugauaguu aggacuuccu                                                   20


<210>  21951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21951
agaucaguuu ggacaacaca                                                   20


<210>  21952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21952
cuguguuguc caaacugauc                                                   20


<210>  21953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21953
agcgaucucc ugccucagcc                                                   20


<210>  21954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21954
gccucccagg uucaagcgau                                                   20


<210>  21955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21955
agcccgggca acaagaguaa                                                   20


<210>  21956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21956
uuuuuuggug agacggagau                                                   20


<210>  21957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21957
uuuuucuuuu uuuggugaga                                                   20


<210>  21958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21958
uuuuuuuuuu uuucuuuuuu                                                   20


<210>  21959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21959
uucuuuuuuu uuuuuuucuu                                                   20


<210>  21960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21960
ccaggcuggg cugacugccc                                                   20


<210>  21961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21961
auguuaagaa cccaaaucca                                                   20


<210>  21962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21962
uaacauggaa aacgucugug                                                   20


<210>  21963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21963
gaaaaggcag uccacacaaa                                                   20


<210>  21964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21964
gaaccuauuu gggugcuaag                                                   20


<210>  21965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21965
uuuauuuggc agauuugugu                                                   20


<210>  21966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21966
gauauugcau uuacgcuaaa                                                   20


<210>  21967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21967
aagguauuua gcguaaaugc                                                   20


<210>  21968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21968
cucucaauuu ccaagguauu                                                   20


<210>  21969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21969
ucuccagauu cccucucaau                                                   20


<210>  21970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21970
uacauccauc uuccucucca                                                   20


<210>  21971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21971
uguaaaguga ggguuuuugu                                                   20


<210>  21972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21972
gcacaggaga ugcuacauug                                                   20


<210>  21973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21973
ccuuaagcgg agaugcuaac                                                   20


<210>  21974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21974
ucaguauguc uucuccuuaa                                                   20


<210>  21975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21975
agaccagccu gggcaacagg                                                   20


<210>  21976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21976
cccuguugcc caggcugguc                                                   20


<210>  21977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21977
uagcucacug cagccuugau                                                   20


<210>  21978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21978
aaacauuagc ccaauuaguu                                                   20


<210>  21979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21979
agggaagaaa aaaacuuagu                                                   20


<210>  21980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21980
cuagaaauac auuuauucua                                                   20


<210>  21981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21981
ucccuagaaa uacauuuauu                                                   20


<210>  21982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21982
aaaaguaaaa aggggaggga                                                   20


<210>  21983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21983
agcaggcuuc aaaaaguaaa                                                   20


<210>  21984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21984
aggaaaacag auuuccuccc                                                   20


<210>  21985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21985
uagaauucca gcaggcuuca                                                   20


<210>  21986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21986
uccccuugcu cucuccuucc                                                   20


<210>  21987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21987
ucacauacuc accaguacuc                                                   20


<210>  21988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21988
cagacccaaa ugcucugcuu                                                   20


<210>  21989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21989
auaaaaucuc agaauacaaa                                                   20


<210>  21990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21990
gagauuuuau agaaguuggu                                                   20


<210>  21991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21991
cauuucccug aaauguacuu                                                   20


<210>  21992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21992
cugaaaugua cuuuggugcu                                                   20


<210>  21993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21993
gggaaaugag aaugcccuuu                                                   20


<210>  21994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21994
ggguagcacc aaaguacauu                                                   20


<210>  21995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21995
acuccagugg uggguguuuu                                                   20


<210>  21996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21996
cuuuagcuuu auuaagguau                                                   20


<210>  21997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21997
uuuuaagugu acaguuggau                                                   20


<210>  21998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21998
auuugccagu uguauacagc                                                   20


<210>  21999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  21999
guaucuugau uuugguggag                                                   20


<210>  22000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22000
agacuggugg acguguucug                                                   20


<210>  22001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22001
cuaacccucu gaccccuucc                                                   20


<210>  22002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22002
uucuaaccac ugaaccccca                                                   20


<210>  22003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22003
aaccacugaa cccccaccua                                                   20


<210>  22004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22004
gugguuagaa ggaagggguc                                                   20


<210>  22005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22005
caacacugug gugguaggug                                                   20


<210>  22006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22006
agaauuuguu acaaauggac                                                   20


<210>  22007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22007
agaauucuca acacuguggu                                                   20


<210>  22008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22008
uccacagagc agaaugauuc                                                   20


<210>  22009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22009
acagagcaga augauucugg                                                   20


<210>  22010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22010
gcucugugga agaaauuaaa                                                   20


<210>  22011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22011
gggauucauc cauggugugg                                                   20


<210>  22012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22012
uccauggugu ggaguguguu                                                   20


<210>  22013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22013
uucuucuacu guugaguugu                                                   20


<210>  22014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22014
ucuacuguug aguuguauuc                                                   20


<210>  22015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22015
acuguugagu uguauuccac                                                   20


<210>  22016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22016
accauagggc guuuauccau                                                   20


<210>  22017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22017
accuauuggu ugccaugugg                                                   20


<210>  22018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22018
uaguggucaa aaagugguca                                                   20


<210>  22019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22019
uauaaacaca ucuacacagu                                                   20


<210>  22020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22020
cuuagguaaa caucuaaggc                                                   20


<210>  22021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22021
agaacacaga aaagguuuug                                                   20


<210>  22022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22022
cgaaaugccu uagauguuua                                                   20


<210>  22023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22023
guguucucga aaugccuuag                                                   20


<210>  22024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22024
cuggagaguu caacuccaaa                                                   20


<210>  22025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22025
acuccaaacc cuauauccca                                                   20


<210>  22026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22026
gaauagaaac cucuccacua                                                   20


<210>  22027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22027
gaauaggaug acauuuggua                                                   20


<210>  22028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22028
auucggaaua ggaugacauu                                                   20


<210>  22029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22029
uuaguguagu ggagagguuu                                                   20


<210>  22030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22030
caucauuucc uuaguguagu                                                   20


<210>  22031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22031
uaaaaugggc auucauuuga                                                   20


<210>  22032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22032
uuugaaucag gccaaauaaa                                                   20


<210>  22033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22033
aaugaaugcc cauuuuaaga                                                   20


<210>  22034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22034
gaguccuaag agcccccacu                                                   20


<210>  22035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22035
gagcuagugg gggcucuuag                                                   20


<210>  22036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22036
accuugccaa aggccuuggg                                                   20


<210>  22037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22037
caaggccuuu ggcaagguag                                                   20


<210>  22038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22038
ucccaaggcc uuuggcaagg                                                   20


<210>  22039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22039
gugcaggaaa uuaagauucc                                                   20


<210>  22040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22040
ugcacugaag cuuugcuguc                                                   20


<210>  22041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22041
cccugccucc cccuccccca                                                   20


<210>  22042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22042
ccucugaucc cccagcccug                                                   20


<210>  22043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22043
uguucaccuc ugauccccca                                                   20


<210>  22044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22044
gcuuccuguu caccucugau                                                   20


<210>  22045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22045
gccacugccu gaggccacuc                                                   20


<210>  22046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22046
uuuaaucagc uuccgccacu                                                   20


<210>  22047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22047
ccuccacucc ccguaccuuc                                                   20


<210>  22048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22048
cccccuugca uuguugucua                                                   20


<210>  22049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22049
guuucucccc cuugcauugu                                                   20


<210>  22050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22050
ucaguuucuc ccccuugcau                                                   20


<210>  22051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22051
guuuucuuca guuucucccc                                                   20


<210>  22052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22052
cucuguuuau ugccaguagu                                                   20


<210>  22053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22053
cuuucucucu guuuauugcc                                                   20


<210>  22054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22054
uaaguaaugu aggugugccu                                                   20


<210>  22055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22055
uacgccuagg gcaauaaaua                                                   20


<210>  22056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22056
cacucuccca uguggccugu                                                   20


<210>  22057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22057
caucugugca uggccucuaa                                                   20


<210>  22058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22058
cuccccauac ucccaucuug                                                   20


<210>  22059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22059
acucuucucu ccccauacuc                                                   20


<210>  22060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22060
uccccuuuga uaucucaucu                                                   20


<210>  22061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22061
uuccaucucc cuaaucucca                                                   20


<210>  22062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22062
aucucccuaa ucuccaauug                                                   20


<210>  22063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22063
gugaugacaa auaacuccua                                                   20


<210>  22064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22064
uaaugauuua ucaccaaaug                                                   20


<210>  22065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22065
uucuucagcu ggaauuuaaa                                                   20


<210>  22066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22066
ucagcuggaa uuuaaaauau                                                   20


<210>  22067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22067
gcuggaauuu aaaauaugga                                                   20


<210>  22068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22068
agcugaagaa agaacauuug                                                   20


<210>  22069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22069
uauuuuacgg augaguccau                                                   20


<210>  22070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22070
uaggguuugu augaaaauaa                                                   20


<210>  22071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22071
uacaaacccu augaagcaua                                                   20


<210>  22072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22072
uagagcagag uaagugcucc                                                   20


<210>  22073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22073
caagcucgga gcacuuacuc                                                   20


<210>  22074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22074
gcugaggugu aacuaauaaa                                                   20


<210>  22075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22075
ccaauuccua guuuggguca                                                   20


<210>  22076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22076
uaguuugggu cagaagaaaa                                                   20


<210>  22077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22077
gacccaaacu aggaauuggg                                                   20


<210>  22078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22078
ucugacccaa acuaggaauu                                                   20


<210>  22079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22079
cuuuucuucu gacccaaacu                                                   20


<210>  22080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22080
ucucccuuuu cccuuuucuu                                                   20


<210>  22081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22081
uuuuuccucu cccuuuuccc                                                   20


<210>  22082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22082
uuuccuuuuu ccucucccuu                                                   20


<210>  22083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22083
caacugacuu gccucccccu                                                   20


<210>  22084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22084
ucugucgggc uguccaccca                                                   20


<210>  22085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22085
ccugucugca cucuccccuc                                                   20


<210>  22086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22086
ccuccuuuac aauuuuggga                                                   20


<210>  22087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22087
uucccauuga gaaauaaaau                                                   20


<210>  22088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22088
cauugagaaa uaaaauccaa                                                   20


<210>  22089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22089
caaugggaau gaaauaauuu                                                   20


<210>  22090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22090
ccaucaccaa gagagccuuc                                                   20


<210>  22091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22091
gaaagaggcc ccccugggca                                                   20


<210>  22092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22092
gaaggcucuc uuggugaugg                                                   20


<210>  22093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22093
accccaccca cgcccccacc                                                   20


<210>  22094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22094
uggagccugu gauaaaagca                                                   20


<210>  22095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22095
aaguuguauu gacccuggug                                                   20


<210>  22096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22096
ggccuauguu auuaccugua                                                   20


<210>  22097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22097
agugcaaagu ccauacaggu                                                   20


<210>  22098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22098
gccaucucac uacagauaac                                                   20


<210>  22099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22099
uuaucacagg aauagcaccc                                                   20


<210>  22100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22100
ugugauaagg aaggcagcua                                                   20


<210>  22101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22101
acucugaggu acugauggac                                                   20


<210>  22102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22102
aggguggggu gcagacauuc                                                   20


<210>  22103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22103
cugccuguug ugaugcuuac                                                   20


<210>  22104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22104
cuaaaaguca aaauauucuc                                                   20


<210>  22105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22105
caaugggccc ucaaucagca                                                   20


<210>  22106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22106
agguaccuuu uguguguaug                                                   20


<210>  22107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22107
uuuccugcuc aaagacaggc                                                   20


<210>  22108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22108
ugcucaaaga caggcaauuc                                                   20


<210>  22109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22109
auaccccuuc ccccaaccaa                                                   20


<210>  22110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22110
cccaaccaaa aacccuugcc                                                   20


<210>  22111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22111
cugccccagg cucccauggu                                                   20


<210>  22112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22112
cugugccuuc ucugccccag                                                   20


<210>  22113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22113
aggcucuaaa uggugcuguc                                                   20


<210>  22114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22114
gagagucucu aaauuacaag                                                   20


<210>  22115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22115
cuauucuuag cuauuuuuua                                                   20


<210>  22116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22116
uagcuauuuu uuaaaacacc                                                   20


<210>  22117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22117
uagguguuuu aaaaaauagc                                                   20


<210>  22118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22118
agagcugcag uauguuucuu                                                   20


<210>  22119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22119
cuuuuccaga gcugcaguau                                                   20


<210>  22120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22120
cuuugguuug uuuguucucu                                                   20


<210>  22121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22121
cauaugaggg ugaccucugg                                                   20


<210>  22122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22122
uuaucaauug acuuuucaca                                                   20


<210>  22123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22123
aucaucuccc cuccgguuau                                                   20


<210>  22124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22124
ugcacaggug cauugcuuuc                                                   20


<210>  22125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22125
guaauccauu uccugcacag                                                   20


<210>  22126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22126
cuguuuccgu aauccauuuc                                                   20


<210>  22127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22127
ugaaauccca gaaaaccaga                                                   20


<210>  22128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22128
ugaacaauuc ccuguuuccg                                                   20


<210>  22129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22129
gggauuucau gaacaauucc                                                   20


<210>  22130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22130
gguuuucugg gauuucauga                                                   20


<210>  22131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22131
cgguucuggu uuucugggau                                                   20


<210>  22132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22132
ggaagucgga aaaacaaauc                                                   20


<210>  22133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22133
agaacuuucc cgguucuggu                                                   20


<210>  22134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22134
gacuuccaga acuuucccgg                                                   20


<210>  22135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22135
auugcuuaag ucaugauuug                                                   20


<210>  22136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22136
guaaacgugu auuggacuuc                                                   20


<210>  22137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22137
gcccuggaca cuugccucau                                                   20


<210>  22138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22138
caaagcucca guucugcccu                                                   20


<210>  22139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22139
caggcagaga cagagcacua                                                   20


<210>  22140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22140
gaguagccug aagcaggaaa                                                   20


<210>  22141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22141
ggcuacucug aacucacuuu                                                   20


<210>  22142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22142
ugcuucaggc uacucugaac                                                   20


<210>  22143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22143
cucuuuccug cuucaggcua                                                   20


<210>  22144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22144
acuuugcugc agguucaagg                                                   20


<210>  22145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22145
aggcaaggau uugagacagu                                                   20


<210>  22146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22146
ggaagagccu ggugaguaca                                                   20


<210>  22147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22147
agaaggggua acugucucaa                                                   20


<210>  22148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22148
cucccagcag ccagcagggg                                                   20


<210>  22149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22149
auaaauggcc caggccccug                                                   20


<210>  22150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22150
cacucuaggu uccacuguga                                                   20


<210>  22151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22151
acugugagug cucucucucu                                                   20


<210>  22152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22152
ucaaaucucc cucacuggau                                                   20


<210>  22153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22153
ggccuaugac ugugacaucc                                                   20


<210>  22154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22154
guuugcaugc ugcuuuucag                                                   20


<210>  22155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22155
ccauggacag ucauaagaga                                                   20


<210>  22156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22156
cucaucucuu augacugucc                                                   20


<210>  22157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22157
gucuucacga uuacuucacg                                                   20


<210>  22158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22158
cgauuacuuc acgauaaauc                                                   20


<210>  22159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22159
cgauaaaucu ggauuccaaa                                                   20


<210>  22160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22160
aaagggacua uaagcucuca                                                   20


<210>  22161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22161
augugagagc uuauaguccc                                                   20


<210>  22162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22162
uuccauguga gagcuuauag                                                   20


<210>  22163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22163
aauucccuuu agcuagcauc                                                   20


<210>  22164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22164
cuuuagcuag cauccccuaa                                                   20


<210>  22165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22165
uugcagccuu ccuuuucucu                                                   20


<210>  22166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22166
uuuucucuag caaaguccuu                                                   20


<210>  22167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22167
cuagcaaagu ccuuccaugc                                                   20


<210>  22168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22168
augcaguagc uaaugaccug                                                   20


<210>  22169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22169
cuagcucauu aaguguuuac                                                   20


<210>  22170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22170
auugaaagga auaccacugu                                                   20


<210>  22171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22171
auggaauguu ucucuagcuc                                                   20


<210>  22172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22172
uuucaaugga auguuucucu                                                   20


<210>  22173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22173
ccccucuuua caaaaggaug                                                   20


<210>  22174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22174
uuuuacaaaa gauuuucccc                                                   20


<210>  22175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22175
gaauaugaau agcuaguauu                                                   20


<210>  22176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22176
gaaaaaucug acuugaucaa                                                   20


<210>  22177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22177
uauucugaaa aaucugacuu                                                   20


<210>  22178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22178
agcauauaug aacugucuuu                                                   20


<210>  22179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22179
uauaugcuug aauacuagcu                                                   20


<210>  22180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22180
agggauugau uaacuuaaag                                                   20


<210>  22181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22181
aagcacucuc auauauccuu                                                   20


<210>  22182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22182
ggagcggcag uuuaagucua                                                   20


<210>  22183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22183
auucaggagc ggcaguuuaa                                                   20


<210>  22184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22184
aauucaauuc aggagcggca                                                   20


<210>  22185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22185
agguagacag auucauggcc                                                   20


<210>  22186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22186
uggccccuaa caucaggaau                                                   20


<210>  22187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22187
ugauguuagg ggccaugaau                                                   20


<210>  22188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22188
agcugauucc ugauguuagg                                                   20


<210>  22189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22189
acuggauggc acuuugcacc                                                   20


<210>  22190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22190
agagcaauuu aacauccuuu                                                   20


<210>  22191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22191
aaaaaaagua aaggauguua                                                   20


<210>  22192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22192
gguccagccu ccuacucuuc                                                   20


<210>  22193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22193
cuuucucuga acuaucaccu                                                   20


<210>  22194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22194
cugaacuauc accuuacuau                                                   20


<210>  22195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22195
gagaaagaga agaguaggag                                                   20


<210>  22196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22196
cccaaaggac ucaguggccu                                                   20


<210>  22197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22197
cccuuugcug augauccagu                                                   20


<210>  22198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22198
cuacuggauc aucagcaaag                                                   20


<210>  22199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22199
uuuaggacaa ugugcaggau                                                   20


<210>  22200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22200
ucugcaggau ggaagugagc                                                   20


<210>  22201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22201
auccugcaga ggaagcuugg                                                   20


<210>  22202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22202
aucaccuggc ucacuuccau                                                   20


<210>  22203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22203
uuggccgagg augaccccau                                                   20


<210>  22204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22204
cuuuggggga ggacaucacu                                                   20


<210>  22205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22205
cccagacuuu ugacucaccc                                                   20


<210>  22206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22206
ugcuuggggu cugacccagu                                                   20


<210>  22207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22207
gugcccaggg cugcuggguc                                                   20


<210>  22208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22208
gacaggcccu gcugguuauc                                                   20


<210>  22209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22209
guguccaggg ccucuucuga                                                   20


<210>  22210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22210
cagggcacac ccugugaucu                                                   20


<210>  22211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22211
ugguaccagg augaugcaau                                                   20


<210>  22212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22212
cuuccuagaa uuggccuggg                                                   20


<210>  22213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22213
uagaauuggc cugggacauu                                                   20


<210>  22214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22214
aggaagggaa guggguaugg                                                   20


<210>  22215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22215
uuauuuagcc accucuggca                                                   20


<210>  22216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22216
aauuuuaaua gcaaauaggc                                                   20


<210>  22217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22217
cuuuacugau cuuaugugag                                                   20


<210>  22218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22218
uucucuuuac ugaucuuaug                                                   20


<210>  22219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22219
ccccuuguca ccucaucugc                                                   20


<210>  22220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22220
uacagaccca gccagacugc                                                   20


<210>  22221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22221
cugaggagcu agagacuugu                                                   20


<210>  22222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22222
uuaagccaca agucucuagc                                                   20


<210>  22223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22223
aauguaugua uaagguacau                                                   20


<210>  22224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22224
ggaugaguug gacagucauc                                                   20


<210>  22225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22225
auuagacaaa cguaguuucu                                                   20


<210>  22226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22226
uguucuauua gacaaacgua                                                   20


<210>  22227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22227
ucuucauuuu ccauuccacu                                                   20


<210>  22228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22228
ucauuuucca uuccacugau                                                   20


<210>  22229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22229
uuuuccauuc cacugauucu                                                   20


<210>  22230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22230
auuccacuga uucugucccc                                                   20


<210>  22231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22231
acugauucug uccccacaca                                                   20


<210>  22232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22232
guccccacac aggcauccaa                                                   20


<210>  22233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22233
cuuuggaugc cugugugggg                                                   20


<210>  22234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22234
ucccuuugga ugccugugug                                                   20


<210>  22235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22235
cgcuggcuuu ucugggagau                                                   20


<210>  22236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22236
gggagaucac ccuacaaugu                                                   20


<210>  22237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22237
ccaguauuca gguuucuggg                                                   20


<210>  22238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22238
gguuucuggg cugccauuau                                                   20


<210>  22239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22239
gggcugccau uaucuucucu                                                   20


<210>  22240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22240
cuggucucgg ggcccaagcc                                                   20


<210>  22241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22241
ccagcucuuu ggcuugggcc                                                   20


<210>  22242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22242
guggccagau acuguucucc                                                   20


<210>  22243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22243
gucacuccca cagagcugca                                                   20


<210>  22244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22244
gggccacagu gcuggaggcu                                                   20


<210>  22245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22245
gccuccagca cuguggccca                                                   20


<210>  22246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22246
uucaggagca auacuccugg                                                   20


<210>  22247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22247
ggagcaauac uccugggaaa                                                   20


<210>  22248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22248
caggaguauu gcuccugaag                                                   20


<210>  22249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22249
guaacuccuc uaagugauau                                                   20


<210>  22250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22250
ucccaggggc aaaaaaggaa                                                   20


<210>  22251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22251
caggggcaaa aaaggaaauu                                                   20


<210>  22252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22252
uuuuuugccc cugggaagaa                                                   20


<210>  22253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22253
ccugcuggcu agguggcccc                                                   20


<210>  22254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22254
acgucccacu uucucaagac                                                   20


<210>  22255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22255
caagacagug uuugccacgg                                                   20


<210>  22256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22256
ugggccucac ugacaccugc                                                   20


<210>  22257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22257
uguuccuggg ccucacugac                                                   20


<210>  22258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22258
gugcugucca ccccuuuggu                                                   20


<210>  22259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22259
uucagugcug uccaccccuu                                                   20


<210>  22260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22260
cagcagccuc uccacucaag                                                   20


<210>  22261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22261
acaugcugug gcccaggugc                                                   20


<210>  22262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22262
uaagcugccu gguacucugc                                                   20


<210>  22263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22263
cuuccuccua auccauaagc                                                   20


<210>  22264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22264
uccuaaucca uaagcaccag                                                   20


<210>  22265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22265
ggagcugcac auggggcuug                                                   20


<210>  22266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22266
gagagagcag ccaccgaccu                                                   20


<210>  22267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22267
guccucugcc caggccugcc                                                   20


<210>  22268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22268
auccagggca cagccgcagg                                                   20


<210>  22269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22269
cucucaagac caccgcucuc                                                   20


<210>  22270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22270
cggggccagu ucccccauua                                                   20


<210>  22271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22271
cccauuaugc acugccucug                                                   20


<210>  22272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22272
ccgccaccau uaaccgugcc                                                   20


<210>  22273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22273
gagaagggca gggagcagcu                                                   20


<210>  22274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22274
cugaaggcac aucugucagc                                                   20


<210>  22275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22275
ugcugggaug auugcucugg                                                   20


<210>  22276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22276
cuggcucuug gguaggcugc                                                   20


<210>  22277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22277
uucccuggcu cuuggguagg                                                   20


<210>  22278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22278
caggggcucu ccuuccuucc                                                   20


<210>  22279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22279
gccauuuuuu cucaggggcu                                                   20


<210>  22280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22280
ucugccauuu uuucucaggg                                                   20


<210>  22281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22281
auucuucugc cauuuuuucu                                                   20


<210>  22282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22282
aucaauacac guagucccuu                                                   20


<210>  22283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22283
caacuccuca ggacaggguu                                                   20


<210>  22284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22284
gagcuaggcu gguggcugcu                                                   20


<210>  22285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22285
agguuugaug ccuacagccc                                                   20


<210>  22286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22286
agccuuggug gauagguaag                                                   20


<210>  22287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22287
ucuuaccuau ccaccaaggc                                                   20


<210>  22288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22288
ucuaccacca auuuccuggc                                                   20


<210>  22289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22289
uggcugugug ucugggagca                                                   20


<210>  22290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22290
ucacugguaa aauguguaug                                                   20


<210>  22291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22291
cugguaaaau guguaugaug                                                   20


<210>  22292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22292
aucagcaacc ccagguuggc                                                   20


<210>  22293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22293
cagacacucu uuuaacuagu                                                   20


<210>  22294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22294
gggucgcugc auccuccucu                                                   20


<210>  22295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22295
cccauuuuac agaggaggau                                                   20


<210>  22296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22296
ggguucuccc auuuuacaga                                                   20


<210>  22297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22297
gaaacaagac cuguuucugg                                                   20


<210>  22298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22298
gaagaugugc caaagauguc                                                   20


<210>  22299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22299
ggaaaguugu ugguaaacau                                                   20


<210>  22300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22300
agaaacaggu cuuguuucag                                                   20


<210>  22301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22301
gaaacacuac cuucauucug                                                   20


<210>  22302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22302
gaaacaauaa uauaaauaag                                                   20


<210>  22303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22303
uucugcuuug auucaauggc                                                   20


<210>  22304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22304
gcuuugauuc aauggcagcc                                                   20


<210>  22305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22305
auggcagcca auuuaauuca                                                   20


<210>  22306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22306
uuugguccaa accuguagug                                                   20


<210>  22307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22307
ggcaaguagc acuacagguu                                                   20


<210>  22308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22308
auuuuguucu ggcaaguagc                                                   20


<210>  22309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22309
cugcccucaa ggagcucaca                                                   20


<210>  22310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22310
ugugacacuu accugugcuc                                                   20


<210>  22311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22311
cccaaaggac cauggcuucc                                                   20


<210>  22312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22312
uuucccccaa aggaccaugg                                                   20


<210>  22313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22313
ucauuucccc caaaggacca                                                   20


<210>  22314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22314
aaauacuuua ccugguuugu                                                   20


<210>  22315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22315
cuuucgggug cuucccugag                                                   20


<210>  22316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22316
ggugcuuccc ugaguggcaa                                                   20


<210>  22317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22317
cugaguggca agagggaaag                                                   20


<210>  22318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22318
cucuugccac ucagggaagc                                                   20


<210>  22319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22319
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  22320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22320
cucuuguugc ccaggcuggg                                                   20


<210>  22321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22321
agcaauucuc cucccucagc                                                   20


<210>  22322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22322
ccucccucag ccuccugagu                                                   20


<210>  22323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22323
ccauguuggu caggcugguc                                                   20


<210>  22324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22324
agcacuuugg gaggccgagg                                                   20


<210>  22325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22325
uaauuacagc agugugcuca                                                   20


<210>  22326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22326
cgucuuaaau uuuuauguga                                                   20


<210>  22327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22327
uguuuucccg ucuuaaauuu                                                   20


<210>  22328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22328
gagaaguuau aucagccccu                                                   20


<210>  22329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22329
cagaaugcau cuuccuguuu                                                   20


<210>  22330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22330
aaaacagccu uuuauucuaa                                                   20


<210>  22331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22331
aauuauuuua cuagugaauu                                                   20


<210>  22332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22332
cuaguaaaau aauuagaaua                                                   20


<210>  22333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22333
auaauucacu aguaaaauaa                                                   20


<210>  22334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22334
uucuacacaa cuuguguugc                                                   20


<210>  22335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22335
acacaacuug uguugcacua                                                   20


<210>  22336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22336
ccuagugcaa cacaaguugu                                                   20


<210>  22337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22337
gggaggaaag gccagaccaa                                                   20


<210>  22338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22338
ucccugaagc ucuguuagcc                                                   20


<210>  22339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22339
cuguggagug aggcauauuu                                                   20


<210>  22340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22340
ggugguacag cuucucugug                                                   20


<210>  22341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22341
aggacuucug gugguacagc                                                   20


<210>  22342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22342
gauagucuug aguugcauug                                                   20


<210>  22343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22343
uaucauucug auagucuuga                                                   20


<210>  22344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22344
ccagcuuuua caaagcagga                                                   20


<210>  22345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22345
cacuguuuac cuacucccug                                                   20


<210>  22346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22346
gugagcaaac ggaaaaauaa                                                   20


<210>  22347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22347
guuugcucac agaauguaga                                                   20


<210>  22348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22348
gaugguuuau uuuuccguuu                                                   20


<210>  22349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22349
gucugugcag uuuuauuagg                                                   20


<210>  22350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22350
ucaucagauu cagaagagua                                                   20


<210>  22351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22351
ucagauucag aagaguagca                                                   20


<210>  22352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22352
gaagaguagc aggggguuuc                                                   20


<210>  22353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22353
gaaucugaug aagaaguuau                                                   20


<210>  22354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22354
cgcuagcaca gauuugagcu                                                   20


<210>  22355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22355
gggaucucag guauugcucc                                                   20


<210>  22356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22356
uuaggagcaa uaccugagau                                                   20


<210>  22357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22357
uucucuuauc uuccuccaac                                                   20


<210>  22358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22358
cuuaucuucc uccaacaucc                                                   20


<210>  22359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22359
uccaacaucc aaaagcagug                                                   20


<210>  22360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22360
cacccaaucc caugcuuucu                                                   20


<210>  22361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22361
aauauuaaaa uaugaauuua                                                   20


<210>  22362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22362
uauuuuaaua uuagaaagca                                                   20


<210>  22363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22363
uaaauucaua uuuuaauauu                                                   20


<210>  22364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22364
cugguauuuc uuaaauucau                                                   20


<210>  22365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22365
gguuuaaaaa aucucuuuuc                                                   20


<210>  22366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22366
ugauauguua auaaaacugu                                                   20


<210>  22367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22367
aucaucauca gagaaaaaca                                                   20


<210>  22368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22368
cugaugauga uugaaaacag                                                   20


<210>  22369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22369
gcucuacugu gcuaccauga                                                   20


<210>  22370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22370
uuugaucacc aauugagugc                                                   20


<210>  22371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22371
aguccuguca cccagaaacu                                                   20


<210>  22372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22372
gggugacagg acuagaauuu                                                   20


<210>  22373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22373
cuuagagauu aaguaccucc                                                   20


<210>  22374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22374
ccagcucauu uuacccacuc                                                   20


<210>  22375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22375
cuccuucccc agcucauuuu                                                   20


<210>  22376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22376
cacugguuca cuccuucccc                                                   20


<210>  22377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22377
uucucacugg uucacuccuu                                                   20


<210>  22378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22378
gggagcccca gacagaccag                                                   20


<210>  22379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22379
uucuugcucu uguccaaaca                                                   20


<210>  22380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22380
ugcucuuguc caaacaccuc                                                   20


<210>  22381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22381
guguguauua agaugacaga                                                   20


<210>  22382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22382
acacauuccg uguguauuaa                                                   20


<210>  22383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22383
uuucaacaca uuccgugugu                                                   20


<210>  22384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22384
acacagacac cuucauuuca                                                   20


<210>  22385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22385
ugcucccauu gccaggacaa                                                   20


<210>  22386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22386
cuaaaccugg ucacuccuag                                                   20


<210>  22387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22387
ccaucuuggg acuaggagug                                                   20


<210>  22388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22388
gcagccucag gaggcucuga                                                   20


<210>  22389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22389
accuggucag agccuccuga                                                   20


<210>  22390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22390
ggcuuuccac cuggucagag                                                   20


<210>  22391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22391
gucuuggguc uccugguugg                                                   20


<210>  22392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22392
ccaggcauug ugacuuuuua                                                   20


<210>  22393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22393
aggagccaga caugucccug                                                   20


<210>  22394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22394
agggacaugu cuggcuccug                                                   20


<210>  22395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22395
ucugagcacu gcaacaauuu                                                   20


<210>  22396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22396
cuggacccuc uccuccaccu                                                   20


<210>  22397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22397
cagauggggc auaacccucc                                                   20


<210>  22398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22398
cagauuuggg caaucuaaug                                                   20


<210>  22399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22399
ggcuuacaaa gccuuggugg                                                   20


<210>  22400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22400
acacccagca guuccuaccc                                                   20


<210>  22401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22401
uacccaggac ugagaagccc                                                   20


<210>  22402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22402
caguccuggg uaggaacugc                                                   20


<210>  22403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22403
cccuccugga aaccuauagc                                                   20


<210>  22404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22404
aggaggguga acaagggcca                                                   20


<210>  22405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22405
cuggcagcua uagguuucca                                                   20


<210>  22406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22406
aggcggguua aauuaguccu                                                   20


<210>  22407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22407
ggaucuuuug ucagagcuuu                                                   20


<210>  22408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22408
cauucaucua aaccuccuga                                                   20


<210>  22409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22409
ucuaaaccuc cugaaaauug                                                   20


<210>  22410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22410
ggagguuuag augaauguga                                                   20


<210>  22411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22411
uugauucuag aaaaaaaaga                                                   20


<210>  22412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22412
agaaaaaaaa gaaagcaaga                                                   20


<210>  22413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22413
agaaucaacg aagcagccaa                                                   20


<210>  22414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22414
uuuuuuucua gaaucaacga                                                   20


<210>  22415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22415
ugcuuucuuu uuuuucuaga                                                   20


<210>  22416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22416
ugcauuucuu gcuuucuuuu                                                   20


<210>  22417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22417
uuuccugcau uucuugcuuu                                                   20


<210>  22418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22418
cucucugccc ccucguuccu                                                   20


<210>  22419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22419
uucccucucu gcccccucgu                                                   20


<210>  22420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22420
agcagauggg guuuuggcug                                                   20


<210>  22421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22421
agcaggcuuc uagcagaugg                                                   20


<210>  22422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22422
agcggcacau ucugagaacu                                                   20


<210>  22423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22423
gagaacucug aagaguacca                                                   20


<210>  22424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22424
cagaaugugc cgcucgaagc                                                   20


<210>  22425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22425
gaguucucag aaugugccgc                                                   20


<210>  22426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22426
guuuggggag uccugccagg                                                   20


<210>  22427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22427
ccagcaauuc cagaacugcu                                                   20


<210>  22428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22428
agaacugcug ccuaccggca                                                   20


<210>  22429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22429
ggaauugcug gggaaaccac                                                   20


<210>  22430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22430
ucauugaucc ugcaugcgug                                                   20


<210>  22431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22431
gggucugccu ggguccaccc                                                   20


<210>  22432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22432
uuucuuaguc acugcaagau                                                   20


<210>  22433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22433
uagucacugc aagauuucac                                                   20


<210>  22434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22434
cccagcccag ccacccacug                                                   20


<210>  22435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22435
guggguggcu gggcugggug                                                   20


<210>  22436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22436
gauagguggc cuccucugcc                                                   20


<210>  22437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22437
agugugucau auccuagcau                                                   20


<210>  22438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22438
uccuggccag ccugcucucc                                                   20


<210>  22439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22439
uugggagagc aggcuggcca                                                   20


<210>  22440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22440
uucuuuggga gagcaggcug                                                   20


<210>  22441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22441
guuauuccuu cuuugggaga                                                   20


<210>  22442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22442
gguuuguaaa uuuauaccaa                                                   20


<210>  22443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22443
ucuugaagug ggagcucagc                                                   20


<210>  22444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22444
ugaaguggga gcucagcauc                                                   20


<210>  22445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22445
agaagaacau ugguauaaau                                                   20


<210>  22446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22446
gggugucccg augcugagcu                                                   20


<210>  22447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22447
gcuauuugcu uuuugccuug                                                   20


<210>  22448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22448
gcagacucau ucugcuauuu                                                   20


<210>  22449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22449
gacuaggagg gcuuggggga                                                   20


<210>  22450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22450
cucagcauuu cagcagguac                                                   20


<210>  22451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22451
gcagguacug cucaccugga                                                   20


<210>  22452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22452
aggugagcag uaccugcuga                                                   20


<210>  22453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22453
caguaaauac aucagcugua                                                   20


<210>  22454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22454
ucaagcuuuc uacuggugcu                                                   20


<210>  22455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22455
agcuuucuac uggugcuuag                                                   20


<210>  22456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22456
acuggugcuu agggacaaug                                                   20


<210>  22457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22457
agacuugauu ggcauugucc                                                   20


<210>  22458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22458
accucucuau auaauuucaa                                                   20


<210>  22459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22459
gggacagaua uguaccugau                                                   20


<210>  22460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22460
uaucacaugc cuccccuacc                                                   20


<210>  22461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22461
uugcuccaaa cuauuaaaac                                                   20


<210>  22462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22462
gcaagccaca acuucccuac                                                   20


<210>  22463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22463
cuacccugug ugcaggcugu                                                   20


<210>  22464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22464
acagccugca cacaggguag                                                   20


<210>  22465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22465
ggguccaccc cacgcuucca                                                   20


<210>  22466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22466
ggaucagaau cccuagucua                                                   20


<210>  22467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22467
gauccagaac uccuuauacu                                                   20


<210>  22468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22468
acuacccuuu cuccugccuc                                                   20


<210>  22469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22469
ccugccucuu cacaggguua                                                   20


<210>  22470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22470
caggguuacu caugagguga                                                   20


<210>  22471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22471
aaagggaugg gcccaauuuu                                                   20


<210>  22472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22472
aauguccauu gugcuguuag                                                   20


<210>  22473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22473
uaagccaaaa aagcuagagg                                                   20


<210>  22474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22474
cuccgauccu cuagcuuuuu                                                   20


<210>  22475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22475
uuucucuccg auccucuagc                                                   20


<210>  22476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22476
gaguauccgu cccuucuuuu                                                   20


<210>  22477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22477
aggguguccu uuggcacccc                                                   20


<210>  22478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22478
uccagauugu uccaaaugcc                                                   20


<210>  22479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22479
agauuguucc aaaugccugc                                                   20


<210>  22480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22480
aaaugccugc ugcaguaaua                                                   20


<210>  22481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22481
uuuggggcug uuauuacugc                                                   20


<210>  22482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22482
ccuacaaguc cugacaaagu                                                   20


<210>  22483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22483
ccaagcugac agcugcucca                                                   20


<210>  22484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22484
gcuggacaaa cacugcaucc                                                   20


<210>  22485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22485
cuguguggau gcaguguuug                                                   20


<210>  22486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22486
uguccuuccc uuaggggcca                                                   20


<210>  22487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22487
cuuaggggcc aaaccagccc                                                   20


<210>  22488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22488
uguccaaccc agugggccuc                                                   20


<210>  22489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22489
cuuuccucca gcucccuaag                                                   20


<210>  22490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22490
uccagcuccc uaagcuguug                                                   20


<210>  22491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22491
gggcacagac agcucuucag                                                   20


<210>  22492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22492
ggcugccaga gcaagagagu                                                   20


<210>  22493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22493
uaacucucuu gcucuggcag                                                   20


<210>  22494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22494
caccucccgg aagcagggga                                                   20


<210>  22495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22495
gggagguggg aaugcaugug                                                   20


<210>  22496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22496
aaaaugauag acccagguag                                                   20


<210>  22497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22497
uggcugacuc uuaaauggga                                                   20


<210>  22498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22498
cauuuaagag ucagccacga                                                   20


<210>  22499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22499
cagagauauc uguaauuggc                                                   20


<210>  22500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22500
cccucccuca gguagaguug                                                   20


<210>  22501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22501
gcccaccguu guuuugggag                                                   20


<210>  22502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22502
ggguauuuac gggaugcaga                                                   20


<210>  22503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22503
ucugccagau gcuguggaga                                                   20


<210>  22504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22504
cccgggcugc aaagccuagu                                                   20


<210>  22505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22505
cgcaccaucu gguuucaccc                                                   20


<210>  22506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22506
cuaucuucuc gcaccaucug                                                   20


<210>  22507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22507
cagccauccu uugacaccca                                                   20


<210>  22508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22508
auggugggug ucaaaggaug                                                   20


<210>  22509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22509
gaccucucug ugauuucuau                                                   20


<210>  22510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22510
uucugaccuc ucugugauuu                                                   20


<210>  22511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22511
cugagggcau ggaggggagg                                                   20


<210>  22512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22512
cucugcauca gaggaagagu                                                   20


<210>  22513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22513
ucugaugcag agagaauuaa                                                   20


<210>  22514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22514
caggccagcu guggucugac                                                   20


<210>  22515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22515
ggucugucaa accccuggaa                                                   20


<210>  22516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22516
agggguuuga cagaccagaa                                                   20


<210>  22517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22517
gacaguguuc cucagaucca                                                   20


<210>  22518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22518
ucagauccag gacagagcug                                                   20


<210>  22519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22519
agccucagug agccggcccc                                                   20


<210>  22520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22520
uggacucagc augccagcug                                                   20


<210>  22521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22521
uagugagcug ccuuuaucau                                                   20


<210>  22522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22522
ccauuuagga gacugcuggg                                                   20


<210>  22523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22523
uccuaaacgc cugauauaua                                                   20


<210>  22524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22524
gucagcaacc ucaaauaaug                                                   20


<210>  22525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22525
uuauagccuc ugcaaaacua                                                   20


<210>  22526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22526
gccuaaacau ucaauuaaug                                                   20


<210>  22527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22527
auuaauguaa uuaaauugcu                                                   20


<210>  22528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22528
auaguuugga ucccaaguua                                                   20


<210>  22529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22529
ucacaugccu uaccagucag                                                   20


<210>  22530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22530
uaauugagua cauauguacg                                                   20


<210>  22531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22531
gaaauacugu cuuugaccuu                                                   20


<210>  22532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22532
gaacaaaaau uagaguuagu                                                   20


<210>  22533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22533
agcucugcag aaugcaaagc                                                   20


<210>  22534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22534
gcagagcuag aagagcauuu                                                   20


<210>  22535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22535
uugucuugcu uugcauucug                                                   20


<210>  22536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22536
uccuugucuu gcuuugcauu                                                   20


<210>  22537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22537
uuucuuccuu gucuugcuuu                                                   20


<210>  22538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22538
uuccuuucuu ccuugucuug                                                   20


<210>  22539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22539
uuccuuccuu ucuuccuugu                                                   20


<210>  22540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22540
uuccuuccuu ccuuucuucc                                                   20


<210>  22541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22541
uuccuuccuu ccuuccuuuc                                                   20


<210>  22542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22542
uuccuuccuu ccuuccuucc                                                   20


<210>  22543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22543
ccuccccucc ccuccccucc                                                   20


<210>  22544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22544
cuuccccucc ccuccccucc                                                   20


<210>  22545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22545
cuucccuucc ccuccccucc                                                   20


<210>  22546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22546
cuucccuucc cuuccccucc                                                   20


<210>  22547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22547
cuucccuucc cuucccuucc                                                   20


<210>  22548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22548
cuucccuucc cuucccuucc                                                   20


<210>  22549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22549
cuucccuucc cuucccuucc                                                   20


<210>  22550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22550
cuucccuucc cuucccuucc                                                   20


<210>  22551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22551
cuucccuucc cuucccuucc                                                   20


<210>  22552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22552
cuucccuucc cuucccuucc                                                   20


<210>  22553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22553
cuucccuucc cuucccuucc                                                   20


<210>  22554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22554
cuucccuucc cuucccuucc                                                   20


<210>  22555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22555
cucccucccu ucccuucccu                                                   20


<210>  22556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22556
ugaaaagcua gaaaacugug                                                   20


<210>  22557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22557
agaaaggcaa gggcccuccu                                                   20


<210>  22558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22558
agcuuuucaa gaaaggcaag                                                   20


<210>  22559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22559
agucaacaag agcacaauag                                                   20


<210>  22560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22560
guucaagcca gaaaaguuaa                                                   20


<210>  22561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22561
agccagaaaa guuaaaaccu                                                   20


<210>  22562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22562
ggcuugaacg gaagcagcuu                                                   20


<210>  22563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22563
caagguuuua acuuuucugg                                                   20


<210>  22564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22564
gauguuuugg agucucucaa                                                   20


<210>  22565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22565
ugagagacuc caaaacaucu                                                   20


<210>  22566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22566
ccuugccugu ccucauuucu                                                   20


<210>  22567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22567
uccccuugcc uguccucauu                                                   20


<210>  22568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22568
acaugcagcu guuucaacag                                                   20


<210>  22569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22569
acagcucacu gcauaacaga                                                   20


<210>  22570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22570
aaguccccag cuuuucuaag                                                   20


<210>  22571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22571
aagacauaug gcagaaaugu                                                   20


<210>  22572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22572
gccauauguc uuagaaaagc                                                   20


<210>  22573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22573
acauuucugc cauaugucuu                                                   20


<210>  22574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22574
aaacagcaca agacagaaag                                                   20


<210>  22575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22575
gucuugugcu guuuggaaga                                                   20


<210>  22576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22576
ccccgcaccc gucgcccccc                                                   20


<210>  22577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22577
cuucuccccg cacccgucgc                                                   20


<210>  22578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22578
ucccuucucc ccgcacccgu                                                   20


<210>  22579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22579
acagcuuguu uuuacuucuu                                                   20


<210>  22580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22580
caguaaucca augcuccugu                                                   20


<210>  22581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22581
aaagcaaaag aacaaaaaaa                                                   20


<210>  22582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22582
uuugcuuuag aaacuguaau                                                   20


<210>  22583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22583
caaaagacau auuacacacg                                                   20


<210>  22584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22584
aaagcuuuaa aaucauaugg                                                   20


<210>  22585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22585
guguugguuc cuaugggguu                                                   20


<210>  22586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22586
uaugggguua cggauaaugc                                                   20


<210>  22587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22587
uuuuuguguu ugcaucuguc                                                   20


<210>  22588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22588
gguuuauugu gauuucuuuu                                                   20


<210>  22589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22589
cucaugucau ggugcuuacu                                                   20


<210>  22590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22590
uucacaaaca aaaguaguug                                                   20


<210>  22591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22591
caaacaaaag uaguugagca                                                   20


<210>  22592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22592
ucucaaagaa ccaaccuaaa                                                   20


<210>  22593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22593
uugagaugaa uaacuacuua                                                   20


<210>  22594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22594
gacaggccca gcacugucua                                                   20


<210>  22595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22595
uccuaguuuu uauuugugua                                                   20


<210>  22596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22596
ggacacaggg aaggccugau                                                   20


<210>  22597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22597
cuguguccug aaccaagugu                                                   20


<210>  22598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22598
caucaggccu ucccuguguc                                                   20


<210>  22599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22599
cugucuccuc uuucacauca                                                   20


<210>  22600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22600
ugggugugca gaauuacacc                                                   20


<210>  22601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22601
gcacacccag gaagcuucuc                                                   20


<210>  22602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22602
uuugccaacu agguaaugug                                                   20


<210>  22603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22603
ggaauagcac aguguggaac                                                   20


<210>  22604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22604
agaaccuccc aguugcauuc                                                   20


<210>  22605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22605
acacugugcu auuccagaac                                                   20


<210>  22606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22606
uguucugaag aggacuuugc                                                   20


<210>  22607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22607
gaagaggacu uugcuuuccu                                                   20


<210>  22608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22608
gaacaggaaa aguccagugc                                                   20


<210>  22609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22609
uccgggaugu aaagcauuug                                                   20


<210>  22610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22610
cuuuggccag uuugccauag                                                   20


<210>  22611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22611
ccuagcaacg cuucucuuug                                                   20


<210>  22612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22612
ugccgugucc auucuccuag                                                   20


<210>  22613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22613
ugggccaagc ugaggcuguu                                                   20


<210>  22614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22614
uccugggcca agcugaggcu                                                   20


<210>  22615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22615
cacggccccu guagcugagc                                                   20


<210>  22616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22616
cugagggucu ccuuggcgac                                                   20


<210>  22617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22617
cugagcuccc ccuuggguua                                                   20


<210>  22618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22618
agaagaguuu guucuacaug                                                   20


<210>  22619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22619
ggaaucauag guaacccaag                                                   20


<210>  22620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22620
acauguggca aagccagcac                                                   20


<210>  22621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22621
cucugucccc ucuauggugc                                                   20


<210>  22622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22622
aaagacaccu uaaguagcag                                                   20


<210>  22623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22623
uugucauagg agagcuccuu                                                   20


<210>  22624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22624
ucugugauug cuaaagccua                                                   20


<210>  22625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22625
gugauugcua aagccuagag                                                   20


<210>  22626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22626
uuggaggagg uccucuaggc                                                   20


<210>  22627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22627
gucugagcca cuuuucuuug                                                   20


<210>  22628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22628
caucagacuc cgaaaucaca                                                   20


<210>  22629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22629
gagucugaug agaaauaaga                                                   20


<210>  22630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22630
ggucuaaaga uucaagcuga                                                   20


<210>  22631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22631
agcugagaaa caagaaagca                                                   20


<210>  22632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22632
cagcuugaau cuuuagacca                                                   20


<210>  22633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22633
uguuucucag cuugaaucuu                                                   20


<210>  22634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22634
ggcccuugca aauuaccccc                                                   20


<210>  22635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22635
aagaauuuuu uuacuuuucc                                                   20


<210>  22636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22636
uggaauccuc auaacaucca                                                   20


<210>  22637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22637
auuagagggc ucugcacucu                                                   20


<210>  22638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22638
aggaaaaagg cucuaugugc                                                   20


<210>  22639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22639
uugaaaggag agugcagagc                                                   20


<210>  22640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22640
uuccagaaau ggggaaaggg                                                   20


<210>  22641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22641
agaaaugggg aaagggagga                                                   20


<210>  22642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22642
ggaaagaagu gggcuggcac                                                   20


<210>  22643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22643
ccauuucugg aaagaagugg                                                   20


<210>  22644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22644
ccuccucccu uuccccauuu                                                   20


<210>  22645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22645
acagguucuc cuccucccuu                                                   20


<210>  22646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22646
ggaagaaauu ccaagccagg                                                   20


<210>  22647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22647
ggaaauccgu uguccucuuu                                                   20


<210>  22648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22648
uccggaaauc cguuguccuc                                                   20


<210>  22649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22649
aagccagggg cuaaccgugg                                                   20


<210>  22650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22650
gagacguccg uguggcucug                                                   20


<210>  22651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22651
guggaagcac aagacacgug                                                   20


<210>  22652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22652
acagaaccgu uuucugagac                                                   20


<210>  22653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22653
caggacucuc acugccacgu                                                   20


<210>  22654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22654
uggacuucuc aggacucuca                                                   20


<210>  22655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22655
aacccauucc uaaauaucac                                                   20


<210>  22656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22656
uaaauaucac caauuaacag                                                   20


<210>  22657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22657
caggucucag guagaccauc                                                   20


<210>  22658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22658
uuuguuuucu caggucucag                                                   20


<210>  22659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22659
cuucguuugu uuucucaggu                                                   20


<210>  22660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22660
uucccuucgu uuguuuucuc                                                   20


<210>  22661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22661
ugcauuucuu ucccuucguu                                                   20


<210>  22662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22662
ggaucaaaag aucaaguugu                                                   20


<210>  22663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22663
uuagcuacca aagacaacuu                                                   20


<210>  22664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22664
cuguuguucu uuagcuacca                                                   20


<210>  22665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22665
uucucuguug uucuuuagcu                                                   20


<210>  22666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22666
uuuuccuucu cuguuguucu                                                   20


<210>  22667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22667
ccuccuccua aucuuuuugu                                                   20


<210>  22668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22668
uuggggaggg ccagguguuu                                                   20


<210>  22669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22669
gagagcccca guugacugcc                                                   20


<210>  22670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22670
ccucacgauc uuccugaaca                                                   20


<210>  22671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22671
ugaacagggc aguagucuag                                                   20


<210>  22672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22672
ggaagaucgu gaggggaaag                                                   20


<210>  22673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22673
guggaugcua gacuacugcc                                                   20


<210>  22674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22674
ggacuucagu ggaugcuaga                                                   20


<210>  22675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22675
ccacuucagg acuucagugg                                                   20


<210>  22676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22676
ggcccauccc aauaaacagc                                                   20


<210>  22677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22677
auucucccag ucaccgagcc                                                   20


<210>  22678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22678
cccagucacc gagccacaca                                                   20


<210>  22679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22679
uuucauacaa cccaucccac                                                   20


<210>  22680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22680
uacaacccau cccaccaguc                                                   20


<210>  22681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22681
cuucgaagua uguccagaau                                                   20


<210>  22682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22682
aaguaugucc agaauccagc                                                   20


<210>  22683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22683
aagggaaaac cggcaggauu                                                   20


<210>  22684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22684
ggacauacuu cgaagggaaa                                                   20


<210>  22685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22685
cacgucccca ccacccuggu                                                   20


<210>  22686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22686
gacugcuucu gccucacuuu                                                   20


<210>  22687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22687
gccucacuuu cccaugcuug                                                   20


<210>  22688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22688
caugcuugag ucucaaaaug                                                   20


<210>  22689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22689
agagagucuc uugggccgca                                                   20


<210>  22690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22690
aucucccuug gagucagagc                                                   20


<210>  22691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22691
aggagccagc uggucuccuc                                                   20


<210>  22692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22692
acucugaccu cagggccccu                                                   20


<210>  22693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22693
uggaaccauc uucucaaaau                                                   20


<210>  22694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22694
aggaagagug uguagagagc                                                   20


<210>  22695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22695
caaaauucuc auggccaacu                                                   20


<210>  22696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22696
cauggccaac uuccucaccu                                                   20


<210>  22697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22697
ucaccucuuu ggagccuuug                                                   20


<210>  22698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22698
cauugggccu ucccuaauua                                                   20


<210>  22699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22699
cuaauuaucc uauuuaaaag                                                   20


<210>  22700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22700
ccaccuuauu uucgugcagg                                                   20


<210>  22701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22701
ugcaggcagu uugaucuucu                                                   20


<210>  22702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22702
cuugccauac uauauaauuc                                                   20


<210>  22703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22703
cauauuuauu ggugcaucuu                                                   20


<210>  22704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22704
gucucucccc agcuagaaag                                                   20


<210>  22705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22705
agcuggggag agacagaaga                                                   20


<210>  22706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22706
augcccaaca ccaagaaccg                                                   20


<210>  22707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22707
ugguguuggg cauagaaagc                                                   20


<210>  22708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22708
cagcaugugg cagguguuca                                                   20


<210>  22709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22709
aaauauuugu ugaaaaauga                                                   20


<210>  22710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22710
acaaauauuu ugaacaccug                                                   20


<210>  22711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22711
uuuuucaaca aauauuuuga                                                   20


<210>  22712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22712
cucauucauu uuucaacaaa                                                   20


<210>  22713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22713
caauuccaaa cugccaggag                                                   20


<210>  22714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22714
aaacugccag gaggccacuc                                                   20


<210>  22715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22715
auuuucccca caggcccuga                                                   20


<210>  22716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22716
ccacaggccc ugagacccac                                                   20


<210>  22717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22717
cugugggucu cagggccugu                                                   20


<210>  22718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22718
cccaaaccag cucaaccccu                                                   20


<210>  22719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22719
uuugguuuua acuggcuccu                                                   20


<210>  22720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22720
uaaggcuuag guggagccuc                                                   20


<210>  22721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22721
agaggcucca ccuaagccuu                                                   20


<210>  22722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22722
ccaggcucuc agccccucuu                                                   20


<210>  22723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22723
ucagaguucu ucccacuggg                                                   20


<210>  22724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22724
ucccacuggg gcugugcagc                                                   20


<210>  22725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22725
cacuggggcu gugcagccaa                                                   20


<210>  22726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22726
aggcacacug agaugcccau                                                   20


<210>  22727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22727
ugcuuucaga uucucccucc                                                   20


<210>  22728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22728
gauucucccu ccuccuggca                                                   20


<210>  22729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22729
cccuccuccu ggcaggggca                                                   20


<210>  22730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22730
cuccugcccu ccccagugcc                                                   20


<210>  22731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22731
accugagagc ccgggaugca                                                   20


<210>  22732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22732
ggcugcaucc cgggcucuca                                                   20


<210>  22733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22733
cacccuagca uacaauuuga                                                   20


<210>  22734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22734
ccugucaaau uguaugcuag                                                   20


<210>  22735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22735
ccuuguuauu gccuacuggg                                                   20


<210>  22736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22736
gacuucuccu uguuauugcc                                                   20


<210>  22737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22737
uuuaauucag acuucuccuu                                                   20


<210>  22738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22738
caaauuggcg aguucuuuua                                                   20


<210>  22739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22739
augugacucc acucuuuucc                                                   20


<210>  22740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22740
guuaccaaua aaacacuuaa                                                   20


<210>  22741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22741
ugcagacaua aagugcuaau                                                   20


<210>  22742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22742
uaaugcuaau auuucccucu                                                   20


<210>  22743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22743
cucugauuuc ugacaguucu                                                   20


<210>  22744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22744
gacaguucuu uuuuuuuccu                                                   20


<210>  22745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22745
uuuuuuuucc uucuucuuuu                                                   20


<210>  22746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22746
uucuucuuuu uuggggcuau                                                   20


<210>  22747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22747
ucuuuuuugg ggcuauuuua                                                   20


<210>  22748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22748
uuuuuggggc uauuuuaagu                                                   20


<210>  22749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22749
aaacugaaga cucaaagagc                                                   20


<210>  22750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22750
guuuugaauc agauuagcgc                                                   20


<210>  22751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22751
ugaaaacaau caucacucag                                                   20


<210>  22752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22752
ugaaauggug caacauguaa                                                   20


<210>  22753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22753
aagccacaga aaauaaguug                                                   20


<210>  22754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22754
guggcuugga aaauacguug                                                   20


<210>  22755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22755
acuuauuuuc uguggcuugg                                                   20


<210>  22756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22756
acuuauuuca acuuauuuuc                                                   20


<210>  22757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22757
uugccuacug cauuuucaac                                                   20


<210>  22758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22758
ucuccaagcu uucaacacuc                                                   20


<210>  22759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22759
ccaagcuuuc aacacucugu                                                   20


<210>  22760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22760
acacucuguu ucuaugaagg                                                   20


<210>  22761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22761
augaaggcaa ggguuggagg                                                   20


<210>  22762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22762
uagaaacaga guguugaaag                                                   20


<210>  22763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22763
uucaaauaaa ucaguaaaau                                                   20


<210>  22764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22764
aauaaaucag uaaaaugaug                                                   20


<210>  22765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22765
ucugcuacgc ccaguggccc                                                   20


<210>  22766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22766
aaggcaaaag aaagggaacc                                                   20


<210>  22767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22767
uuugccuuug aacaccuaca                                                   20


<210>  22768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22768
cuuucuuuug ccuuugaaca                                                   20


<210>  22769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22769
caggaaauac aagugucaca                                                   20


<210>  22770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22770
ugggaagcgu uacuaugucu                                                   20


<210>  22771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22771
uuuuggagug acugugacac                                                   20


<210>  22772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22772
aacaacuugg aaggcuaagg                                                   20


<210>  22773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22773
aaguuguuug aauuaaguug                                                   20


<210>  22774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22774
ucugcagcuc cccagcucca                                                   20


<210>  22775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22775
ucucugacug cucuccaggg                                                   20


<210>  22776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22776
ucagauguuu uaaaggaagc                                                   20


<210>  22777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22777
uuuaaaacau cugaggaaag                                                   20


<210>  22778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22778
acagugacag guggggcucu                                                   20


<210>  22779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22779
acaucagcgc aucgggcagc                                                   20


<210>  22780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22780
gaguuccaca ucagcgcauc                                                   20


<210>  22781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22781
uuugggcuug uggcugagcu                                                   20


<210>  22782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22782
ccucccuugg ccuguguccu                                                   20


<210>  22783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22783
uggcugcaca ucuugcucuc                                                   20


<210>  22784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22784
accugccccu gugccacaca                                                   20


<210>  22785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22785
cauuugagag gcgagugugu                                                   20


<210>  22786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22786
cggcuccccu cccaacccag                                                   20


<210>  22787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22787
ggguugggag gggagccggg                                                   20


<210>  22788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22788
uuagaccaaa uaauuuagag                                                   20


<210>  22789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22789
guuuucuuua gaccaaauaa                                                   20


<210>  22790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22790
auaauauaau uaucaaggca                                                   20


<210>  22791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22791
aguaacguag ggaugccuug                                                   20


<210>  22792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22792
uaaucuggcg acguucacag                                                   20


<210>  22793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22793
cagccuuaug aagacaguuu                                                   20


<210>  22794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22794
uaaggcugug aacgucgcca                                                   20


<210>  22795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22795
cuuuuagugu cucaaguaug                                                   20


<210>  22796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22796
ccuauccguc aucagaggug                                                   20


<210>  22797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22797
uuuacuuuag guguguauug                                                   20


<210>  22798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22798
cugugucucc uccaaaugga                                                   20


<210>  22799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22799
ccucuuagac gucucagaga                                                   20


<210>  22800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22800
caaaaaugaa cacacagagc                                                   20


<210>  22801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22801
uuuuugagaa aauguuaauc                                                   20


<210>  22802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22802
caggggguaa ccagaggugg                                                   20


<210>  22803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22803
cugccuuucu caggggguaa                                                   20


<210>  22804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22804
ggggguccuu ucucugccuu                                                   20


<210>  22805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22805
gggaucauga ggacucacca                                                   20


<210>  22806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22806
gugggguggu gaguccucau                                                   20


<210>  22807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22807
caucuuugag cggcucuucc                                                   20


<210>  22808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22808
ccagagucag gaugacucuc                                                   20


<210>  22809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22809
gguacauccc caucaugccc                                                   20


<210>  22810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22810
uuguccccuc cuugucucau                                                   20


<210>  22811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22811
agugccacuc cugggacuaa                                                   20


<210>  22812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22812
ggagaugcug ccuccacgcc                                                   20


<210>  22813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22813
gcuguggaca gccucaagug                                                   20


<210>  22814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22814
cauggggugg cuggcuugag                                                   20


<210>  22815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22815
ggcuagaggc uaacccaaca                                                   20


<210>  22816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22816
cucuuugugg agcaaaucuu                                                   20


<210>  22817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22817
uguccugucu ggaucuuccc                                                   20


<210>  22818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22818
caguccugcc cucucucuuc                                                   20


<210>  22819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22819
gaaucuuccc acccuuccaa                                                   20


<210>  22820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22820
gaagagagag ggcaggacug                                                   20


<210>  22821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22821
cacccuucca agggccugcu                                                   20


<210>  22822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22822
aagggccugc ugccuaaucc                                                   20


<210>  22823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22823
uuuacuuuag cgugugagug                                                   20


<210>  22824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22824
guccugauca gggaugaguc                                                   20


<210>  22825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22825
uuuuucaguc cugaucaggg                                                   20


<210>  22826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22826
uuuucuuuuu ucaguccuga                                                   20


<210>  22827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22827
cagagagugg ugugauggga                                                   20


<210>  22828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22828
auuuucccag agaguggugu                                                   20


<210>  22829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22829
uaggugcuga cccagcugug                                                   20


<210>  22830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22830
cugcauagga cccuucguag                                                   20


<210>  22831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22831
gacugcaagg uguucacugc                                                   20


<210>  22832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22832
caacaagcca gagauucucu                                                   20


<210>  22833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22833
cugccuucca gacaggcacc                                                   20


<210>  22834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22834
agacaggcac cuccaugaag                                                   20


<210>  22835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22835
uggaggugcc ugucuggaag                                                   20


<210>  22836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22836
cuucauggag gugccugucu                                                   20


<210>  22837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22837
uggcuugugg ugagcaaaac                                                   20


<210>  22838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22838
aguuccacua cuuugaauuc                                                   20


<210>  22839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22839
acuacuuuga auucucuagg                                                   20


<210>  22840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22840
aaguagugga acuagaaucc                                                   20


<210>  22841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22841
cuagguucac aguccuaaau                                                   20


<210>  22842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22842
caguccuaaa uccucagaga                                                   20


<210>  22843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22843
cugaggauuu aggacuguga                                                   20


<210>  22844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22844
ugagagcacg ugcagcuagc                                                   20


<210>  22845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22845
aggcuggagc ucugagaggc                                                   20


<210>  22846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22846
aggcugggcu accuccagcc                                                   20


<210>  22847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22847
accacauggc uggagguagc                                                   20


<210>  22848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22848
uuugcuacca guuuccacca                                                   20


<210>  22849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22849
gggcuuccuu ugcuaccagu                                                   20


<210>  22850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22850
guuguggccc uucugggcuu                                                   20


<210>  22851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22851
aguucaguug uggcccuucu                                                   20


<210>  22852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22852
uuagccuucu aguucaguug                                                   20


<210>  22853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22853
gggcaguccc aagacuugga                                                   20


<210>  22854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22854
ccaagucuug ggacugccca                                                   20


<210>  22855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22855
gauggcuugu ucuccaaguc                                                   20


<210>  22856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22856
auuuucagau ggcuuguucu                                                   20


<210>  22857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22857
agaccagccu agccaacaug                                                   20


<210>  22858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22858
ccauguuggc uaggcugguc                                                   20


<210>  22859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22859
ccugccucag ccucccaagu                                                   20


<210>  22860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22860
agugauucuc cugccucagc                                                   20


<210>  22861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22861
uaggaaaaaa aucagaguug                                                   20


<210>  22862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22862
uaagaaacuc ccccacccaa                                                   20


<210>  22863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22863
uuguguugua aagacaguca                                                   20


<210>  22864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22864
cagccucuua uggugccuua                                                   20


<210>  22865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22865
auugauaaga gaggauuucc                                                   20


<210>  22866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22866
cuacucaaau aucaaagguc                                                   20


<210>  22867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22867
guuuuagugu auguguaugc                                                   20


<210>  22868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22868
uuuuucuguu uuaguguaug                                                   20


<210>  22869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22869
uuuuuuuuuu uucuuuuuuc                                                   20


<210>  22870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22870
cucucucucu cugucucucu                                                   20


<210>  22871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22871
uuuggguggc uuugacuggc                                                   20


<210>  22872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22872
gaacucagcc guucucccuc                                                   20


<210>  22873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22873
gaagggacug gggccugcuu                                                   20


<210>  22874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22874
cccucuggug agacaggcuc                                                   20


<210>  22875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22875
agaaugccac uaccagcuuc                                                   20


<210>  22876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22876
ggaaacaagc uagagccugu                                                   20


<210>  22877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22877
cacaccucca ggggaccccc                                                   20


<210>  22878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22878
ccaacacugg cuuccaggug                                                   20


<210>  22879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22879
aggugagcga gacagaaucu                                                   20


<210>  22880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22880
gucucgcuca ccuggaagcc                                                   20


<210>  22881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22881
cugcuugacc auggggugaa                                                   20


<210>  22882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22882
ccccaugguc aagcagugaa                                                   20


<210>  22883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22883
cuuuuucacu uucuccccag                                                   20


<210>  22884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22884
cuuucucccc agggaggaag                                                   20


<210>  22885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22885
ccccagggag gaagggggaa                                                   20


<210>  22886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22886
ucccugggga gaaagugaaa                                                   20


<210>  22887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22887
cccuuccucc cuggggagaa                                                   20


<210>  22888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22888
cuggacaggg agcuggggau                                                   20


<210>  22889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22889
aagcccgguc uuucucuguu                                                   20


<210>  22890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22890
cuguucaauc aagcagcgug                                                   20


<210>  22891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22891
aucaagcagc gugagcaaag                                                   20


<210>  22892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22892
uauguaguau uuaaucugua                                                   20


<210>  22893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22893
uggugccuaa cauaaugcug                                                   20


<210>  22894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22894
ccuccucaaa uuauaaccuu                                                   20


<210>  22895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22895
cauuggcucg uggguguauu                                                   20


<210>  22896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22896
uuggaggagg ugucacucug                                                   20


<210>  22897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22897
uaguuaccua gaaaaauggc                                                   20


<210>  22898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22898
agguaacuag gaaggccuga                                                   20


<210>  22899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22899
agugggcugg accuccccag                                                   20


<210>  22900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22900
guaucuccuu cuagugggcu                                                   20


<210>  22901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22901
gagagguagc ugggucccac                                                   20


<210>  22902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22902
ggcagggaga aagugguggu                                                   20


<210>  22903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22903
cccugccuga aagcacuggg                                                   20


<210>  22904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22904
aaaugacucu ugaucaccca                                                   20


<210>  22905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22905
agcuucccca uuucugcccc                                                   20


<210>  22906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22906
ccauuucugc cccugacuug                                                   20


<210>  22907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22907
gccccugacu ugagcuccca                                                   20


<210>  22908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22908
gcgcagccug guggugacuc                                                   20


<210>  22909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22909
uguucagcgc agccuggugg                                                   20


<210>  22910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22910
cuuccuguuc agcgcagccu                                                   20


<210>  22911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22911
agaaagaucc aauaagggaa                                                   20


<210>  22912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22912
cgaauugacu uguucacuuc                                                   20


<210>  22913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22913
cuuauuggau cuuucucgaa                                                   20


<210>  22914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22914
cugggcaccg cugggccaac                                                   20


<210>  22915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22915
aggaccccuc cguggguguu                                                   20


<210>  22916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22916
gacuccaggg uauuuguauu                                                   20


<210>  22917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22917
caccacuuca auuaugucuu                                                   20


<210>  22918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22918
auuaugucuu cauugaacug                                                   20


<210>  22919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22919
uugaacuggg uuaugaaaaa                                                   20


<210>  22920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22920
augaagacau aauugaagug                                                   20


<210>  22921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22921
uaacccaguu caaugaagac                                                   20


<210>  22922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22922
cuuuuucaua acccaguuca                                                   20


<210>  22923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22923
aucccugcuu cccuuuuuca                                                   20


<210>  22924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22924
caugucugua augcuuuuca                                                   20


<210>  22925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22925
uaucauccua cacacucacu                                                   20


<210>  22926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22926
gugugcuggg gugaggagag                                                   20


<210>  22927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22927
agcaaaaccu guguuuuaau                                                   20


<210>  22928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22928
cugugagcca gcagagccaa                                                   20


<210>  22929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22929
aaaaccuuug uucuccagau                                                   20


<210>  22930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22930
ccagauguca gugcaaaguu                                                   20


<210>  22931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22931
uaacuuugca cugacaucug                                                   20


<210>  22932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22932
ugccucacuu acugcucggu                                                   20


<210>  22933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22933
cagccuccau gaagucguca                                                   20


<210>  22934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22934
uggaggcuga gaaauauagu                                                   20


<210>  22935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22935
ccggaugacg gugaguuacg                                                   20


<210>  22936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22936
ucuccacuuc cccggaugac                                                   20


<210>  22937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22937
cugacuuccu cuccacuucc                                                   20


<210>  22938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22938
cccaucccag gugccccucu                                                   20


<210>  22939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22939
cucccaguug uccugaugcc                                                   20


<210>  22940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22940
uaguggacac caagcugagc                                                   20


<210>  22941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22941
uugaugacuc augcucagcu                                                   20


<210>  22942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22942
uuagucuuau gucugcacuc                                                   20


<210>  22943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22943
acauucuuua gucuuauguc                                                   20


<210>  22944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22944
agcucuuuua cucaaacauu                                                   20


<210>  22945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22945
aaagagaggc auagaaacaa                                                   20


<210>  22946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22946
augccucucu uuagaaucug                                                   20


<210>  22947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22947
gguucaggaa agagauuauu                                                   20


<210>  22948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22948
ggaaagagau uauuuaggaa                                                   20


<210>  22949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22949
ugaaccugaa cucauggauc                                                   20


<210>  22950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22950
uaaauaaucu cuuuccugaa                                                   20


<210>  22951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22951
uccuaaauaa ucucuuuccu                                                   20


<210>  22952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22952
ucuuccuaaa uaaucucuuu                                                   20


<210>  22953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22953
ccgccacuuc uucuuccuaa                                                   20


<210>  22954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22954
auucuccgcc acuucuucuu                                                   20


<210>  22955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22955
uuccauucuc cgccacuucu                                                   20


<210>  22956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22956
ucauuccauu cuccgccacu                                                   20


<210>  22957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22957
uauuuuacau ucuucauucc                                                   20


<210>  22958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22958
gcccaaagcu ggugaugaga                                                   20


<210>  22959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22959
agagacgaca aaguaucuca                                                   20


<210>  22960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22960
uuccagagac gacaaaguau                                                   20


<210>  22961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22961
ucuucauucc agagacgaca                                                   20


<210>  22962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22962
uuuuaaaccc auuuccucuu                                                   20


<210>  22963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22963
aucccuuaug cuucauuuua                                                   20


<210>  22964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22964
uuuugucuac cuucgauccc                                                   20


<210>  22965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22965
ugcgauugag aggugucuuu                                                   20


<210>  22966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22966
auuuuuaaag acaccucuca                                                   20


<210>  22967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22967
ucaccacccu aguucuauuu                                                   20


<210>  22968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22968
ggagggccau cugccccuga                                                   20


<210>  22969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22969
uucaccaccc caacuccauc                                                   20


<210>  22970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22970
ccaccccaac uccaucuacu                                                   20


<210>  22971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22971
gauaacugga gauaauggag                                                   20


<210>  22972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22972
cugggcacac cauguaaacc                                                   20


<210>  22973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22973
gggguuuaca uggugugccc                                                   20


<210>  22974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22974
ugcuagggcu cccaaagugu                                                   20


<210>  22975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22975
uaccaccuuu ccugcuaggg                                                   20


<210>  22976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22976
gggcuggucu uccuaccacc                                                   20


<210>  22977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22977
cugcccuuuu ucggggcugg                                                   20


<210>  22978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22978
cuguuuucuc ugcccuuuuu                                                   20


<210>  22979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22979
uuucccuguu uucucugccc                                                   20


<210>  22980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22980
ugccuuguuc cuuucccugu                                                   20


<210>  22981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22981
ucuugccuug uuccuuuccc                                                   20


<210>  22982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22982
cugcaacagc acaggugauu                                                   20


<210>  22983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22983
acaaagcucc aguuaagaaa                                                   20


<210>  22984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22984
uaacuggagc uuuguugaag                                                   20


<210>  22985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22985
agccaucacc gauaaaagcg                                                   20


<210>  22986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22986
ucugcaaagc acaugcgggc                                                   20


<210>  22987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22987
uggcugacug uaccaaucgc                                                   20


<210>  22988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22988
uuccuggcug acuguaccaa                                                   20


<210>  22989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22989
cacuuucauu ccuggcugac                                                   20


<210>  22990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22990
caucuguaaa augacagggu                                                   20


<210>  22991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22991
caagucuaug ucuacauaga                                                   20


<210>  22992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22992
auguagacau agacuuguga                                                   20


<210>  22993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22993
cuuuggcuuu ccacgaagga                                                   20


<210>  22994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22994
acgaaggaaa cuaucuaugc                                                   20


<210>  22995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22995
uggaaagcca aagugaauac                                                   20


<210>  22996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22996
uucguggaaa gccaaaguga                                                   20


<210>  22997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22997
ucuaugauuc cucagaaacu                                                   20


<210>  22998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22998
augauuccuc agaaacucuu                                                   20


<210>  22999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  22999
ucagaaacuc uugucgacua                                                   20


<210>  23000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23000
gaggaaucau agaagaaagc                                                   20


<210>  23001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23001
ucuagucgac aagaguuucu                                                   20


<210>  23002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23002
uguuccucua gucgacaaga                                                   20


<210>  23003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23003
cuccuccccu aaaauugggu                                                   20


<210>  23004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23004
aguaauuaau uuaaagucuu                                                   20


<210>  23005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23005
gagauuauag gcauaagcaa                                                   20


<210>  23006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23006
aaauuucuga gauuauaggc                                                   20


<210>  23007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23007
cucuguggcc uuccaaauuu                                                   20


<210>  23008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23008
agcaaucuuc ccucuguggc                                                   20


<210>  23009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23009
agaccagccu gggcaacaua                                                   20


<210>  23010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23010
aagaaaauau aaaauuuggc                                                   20


<210>  23011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23011
uugaaaagau agcuaaaucu                                                   20


<210>  23012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23012
cucugucaac aucugcugag                                                   20


<210>  23013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23013
auaccagugu guuacagccu                                                   20


<210>  23014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23014
ugacaggcug uaacacacug                                                   20


<210>  23015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23015
cugagucugc uucaugacag                                                   20


<210>  23016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23016
ggauuaugcc uguaagauga                                                   20


<210>  23017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23017
aacucaccug cauuuaaaua                                                   20


<210>  23018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23018
uauuuaaaug caggugaguu                                                   20


<210>  23019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23019
gcucacucuu uauucauauu                                                   20


<210>  23020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23020
caugugcgau gcccucccau                                                   20


<210>  23021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23021
cacacgcaaa ggcauggggg                                                   20


<210>  23022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23022
ugccuugucc ccccaugccu                                                   20


<210>  23023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23023
cagaucuaga gcaaugcuuc                                                   20


<210>  23024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23024
cugcuggguu ugugugucac                                                   20


<210>  23025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23025
caacguucuc ugcuggguuu                                                   20


<210>  23026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23026
cuuaaaaguc cauccagaau                                                   20


<210>  23027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23027
ggauggacuu uuaagugaac                                                   20


<210>  23028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23028
gauucuggau ggacuuuuaa                                                   20


<210>  23029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23029
ugggggccgg gcguggauuu                                                   20


<210>  23030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23030
aguucagguc aagcuggaug                                                   20


<210>  23031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23031
ggucaagcug gauggacacc                                                   20


<210>  23032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23032
ccaccagccg uauuuccugg                                                   20


<210>  23033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23033
uggggcugcu uguuacugac                                                   20


<210>  23034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23034
gucauucaag guggguccug                                                   20


<210>  23035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23035
aggugggucc ugaagccaca                                                   20


<210>  23036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23036
ggacccaccu ugaaugacag                                                   20


<210>  23037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23037
uucuuuuaaa gagcgauggc                                                   20


<210>  23038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23038
uuuaaagagc gauggcacac                                                   20


<210>  23039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23039
cucaagaguu gagagaugug                                                   20


<210>  23040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23040
guccauuuuc ucucaagagu                                                   20


<210>  23041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23041
auccugauac cagcaggaaa                                                   20


<210>  23042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23042
ugcugguauc aggauugaaa                                                   20


<210>  23043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23043
ugguuuggua guaccuacca                                                   20


<210>  23044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23044
uuucucccaa guacaccagg                                                   20


<210>  23045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23045
cccaaguaca ccaggaaccc                                                   20


<210>  23046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23046
ugguguacuu gggagaaaag                                                   20


<210>  23047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23047
aauacaggcg cuacaaaaaa                                                   20


<210>  23048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23048
uuuuuuguag cgccuguauu                                                   20


<210>  23049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23049
caccuauuuc uuuuuuugua                                                   20


<210>  23050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23050
ugccccgcuu ucacaccuau                                                   20


<210>  23051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23051
cuuucuugcc ccgcuuucac                                                   20


<210>  23052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23052
auaaccucca uauugagaga                                                   20


<210>  23053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23053
guguuuuaug ucucucaaua                                                   20


<210>  23054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23054
gggcccagca ccugacaggu                                                   20


<210>  23055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23055
gcugccugga gauaguucag                                                   20


<210>  23056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23056
caucauuaaa aagcugaugu                                                   20


<210>  23057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23057
aacauguuuu uaaucuuuaa                                                   20


<210>  23058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23058
acacccaucu cuccuuacag                                                   20


<210>  23059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23059
uacgauguuc cacacccauc                                                   20


<210>  23060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23060
cugcagcaug agugcaguca                                                   20


<210>  23061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23061
uuccuuacaa gagaaaucgc                                                   20


<210>  23062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23062
uuacaagaga aaucgcuccu                                                   20


<210>  23063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23063
cuuguaagga aagaaggcag                                                   20


<210>  23064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23064
ggagcgauuu cucuuguaag                                                   20


<210>  23065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23065
ccagugguca acuuacugcu                                                   20


<210>  23066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23066
agccucacuu ucuccagugg                                                   20


<210>  23067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23067
agugguucca gccucacuuu                                                   20


<210>  23068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23068
gaggccaguu cuguucugac                                                   20


<210>  23069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23069
guucugacac augcagcugg                                                   20


<210>  23070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23070
gacacaugca gcugggagcc                                                   20


<210>  23071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23071
uaaaccagug gcucccagcu                                                   20


<210>  23072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23072
cgugggcaug ggacugugcu                                                   20


<210>  23073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23073
gaaagggcuc ccagucacau                                                   20


<210>  23074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23074
gaauaagcac agucccaugc                                                   20


<210>  23075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23075
ccuaaauuac uccaaugaca                                                   20


<210>  23076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23076
uugucauugg aguaauuuag                                                   20


<210>  23077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23077
cugaguuuuc uuugucauug                                                   20


<210>  23078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23078
uaggcauugu cauuugccaa                                                   20


<210>  23079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23079
ugaguuaugg auuggcaaau                                                   20


<210>  23080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23080
uggcuaugcu uggauaauuc                                                   20


<210>  23081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23081
cucuagacuu ggaguguuaa                                                   20


<210>  23082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23082
ccccucucuc uggcaggaga                                                   20


<210>  23083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23083
ccugccagag agaggggaga                                                   20


<210>  23084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23084
aauaauucgg ccuaaauuuu                                                   20


<210>  23085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23085
gccuaaauuu ucauuuaugc                                                   20


<210>  23086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23086
uuuaugccug uguauuuaug                                                   20


<210>  23087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23087
uuuucugaaa auugaaaaau                                                   20


<210>  23088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23088
gaaaauugaa aaauucagaa                                                   20


<210>  23089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23089
gaaaaagaag ccauaauacu                                                   20


<210>  23090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23090
auuuucagaa aaagaagcca                                                   20


<210>  23091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23091
gaaagccaaa gauaauagaa                                                   20


<210>  23092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23092
gaauuuuuca auuuucagaa                                                   20


<210>  23093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23093
auuaucuuug gcuuucugaa                                                   20


<210>  23094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23094
uaccuaauca auauaccuug                                                   20


<210>  23095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23095
ucaaaaguuc ccaggcaaau                                                   20


<210>  23096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23096
caggcaaaug gguuccucuu                                                   20


<210>  23097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23097
ucuuuaauuu ucacccuuac                                                   20


<210>  23098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23098
cccuuacaau aaacucuucu                                                   20


<210>  23099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23099
gcagguuuug uuuauuuuga                                                   20


<210>  23100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23100
ucaaaauaaa caaaaccugc                                                   20


<210>  23101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23101
cuuuuuuuuu caagacauga                                                   20


<210>  23102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23102
agacaugagg ugugaaugau                                                   20


<210>  23103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23103
caccucaugu cuugaaaaaa                                                   20


<210>  23104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23104
guuuacauau ccaaauacug                                                   20


<210>  23105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23105
ggagucugag gaccugaaau                                                   20


<210>  23106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23106
gguccucaga cuccagaauu                                                   20


<210>  23107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23107
gugggauaau guacacauuu                                                   20


<210>  23108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23108
cauuccguuu auaagaagga                                                   20


<210>  23109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23109
guuuauaaga aggagaaauu                                                   20


<210>  23110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23110
uauaaacgga augcgaaugu                                                   20


<210>  23111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23111
ccuucuuaua aacggaaugc                                                   20


<210>  23112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23112
gaggaaaauu aaauaagugg                                                   20


<210>  23113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23113
ucagaaaacu cugugaggau                                                   20


<210>  23114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23114
uaggcacaac cacagaagca                                                   20


<210>  23115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23115
gugguugugc cuaugaauuu                                                   20


<210>  23116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23116
cucuccuugg ugcuucugug                                                   20


<210>  23117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23117
guaggcgacc aacauggggu                                                   20


<210>  23118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23118
uguagauucc guaggcgacc                                                   20


<210>  23119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23119
gauuccugua gauuccguag                                                   20


<210>  23120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23120
gccuauacca cccaucagau                                                   20


<210>  23121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23121
guugguggcu gaucugaugg                                                   20


<210>  23122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23122
ccaguggguu cccaccggug                                                   20


<210>  23123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23123
caccgguguu uucgugcaag                                                   20


<210>  23124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23124
ugcaagcuua gccccuucuu                                                   20


<210>  23125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23125
uugcagaaaa aaagauauug                                                   20


<210>  23126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23126
gcaaagaagg ggcuaagcuu                                                   20


<210>  23127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23127
acuguuggca caucaauauc                                                   20


<210>  23128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23128
uucuacuguu ggcacaucaa                                                   20


<210>  23129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23129
ucuuucuacu guuggcacau                                                   20


<210>  23130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23130
agcucuguac acaaccuuug                                                   20


<210>  23131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23131
cagacuuggu uuuaucaugc                                                   20


<210>  23132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23132
aaaaaguguu uagacaaaua                                                   20


<210>  23133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23133
ucccuuucca aaaaguguuu                                                   20


<210>  23134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23134
ucuccauuuc aucccuuucc                                                   20


<210>  23135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23135
uuuccucucc auuucauccc                                                   20


<210>  23136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23136
uuuuccuuuc cucuccauuu                                                   20


<210>  23137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23137
acaacagcug ccuuccauug                                                   20


<210>  23138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23138
auugucuacu gccagugaag                                                   20


<210>  23139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23139
cuggcaguag acaauggaag                                                   20


<210>  23140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23140
cacagaggcu auuauuagca                                                   20


<210>  23141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23141
cagacccagg cccaggccca                                                   20


<210>  23142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23142
aggcagcaga uacggcagag                                                   20


<210>  23143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23143
ugcagcccgu cacaggggag                                                   20


<210>  23144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23144
agucacacag cgacaguccu                                                   20


<210>  23145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23145
agauagcaaa agccaggacu                                                   20


<210>  23146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23146
ucuagauagc aaaagccagg                                                   20


<210>  23147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23147
ccuuuccagc ucugcaauug                                                   20


<210>  23148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23148
agcucugcaa uugccacucu                                                   20


<210>  23149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23149
ucuuccaucu ugugccccag                                                   20


<210>  23150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23150
aucuugugcc ccaguccucc                                                   20


<210>  23151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23151
cuuuaaggga ggacuggggc                                                   20


<210>  23152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23152
uuguccccuu cuuucugaga                                                   20


<210>  23153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23153
uucugagagu guggucaauc                                                   20


<210>  23154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23154
gagagugugg ucaaucuccu                                                   20


<210>  23155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23155
cuaauagcca gggcucaaau                                                   20


<210>  23156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23156
uuggccauuu gagcccuggc                                                   20


<210>  23157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23157
uaacacuacc agccacguga                                                   20


<210>  23158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23158
uccugacccu caccacgagg                                                   20


<210>  23159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23159
ugacccucac cacgaggcac                                                   20


<210>  23160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23160
gcacaggugc cucugugccu                                                   20


<210>  23161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23161
gugcaugagg cagagucaga                                                   20


<210>  23162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23162
uccaggagaa ugggggacag                                                   20


<210>  23163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23163
aggagaaugg gggacagugc                                                   20


<210>  23164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23164
ccuggaagaa cagagauccc                                                   20


<210>  23165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23165
caaugaacuu cccagauaca                                                   20


<210>  23166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23166
uugugaaggg gucauuuaag                                                   20


<210>  23167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23167
cagauacaag acuugagcuc                                                   20


<210>  23168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23168
ugcccauagg acacuugucc                                                   20


<210>  23169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23169
ccaaggguuu ggcucagagg                                                   20


<210>  23170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23170
ucaccaaggg uuuggcucag                                                   20


<210>  23171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23171
ggaaaaaucu caaauacuac                                                   20


<210>  23172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23172
agaaaauaaa gguauugccu                                                   20


<210>  23173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23173
cucuacuuuu guaguauuug                                                   20


<210>  23174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23174
agcuccaacc accacagcuc                                                   20


<210>  23175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23175
ugucuucugu aacccuaucg                                                   20


<210>  23176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23176
guaacccuau cgccucccua                                                   20


<210>  23177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23177
ucaguaaaca ccucuguaug                                                   20


<210>  23178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23178
uauguuuaaa aaauacauac                                                   20


<210>  23179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23179
uuuaaauaca acugcaaaac                                                   20


<210>  23180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23180
gaguuuaaaa uaacuccccu                                                   20


<210>  23181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23181
uuccaucugg gucauguuuu                                                   20


<210>  23182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23182
aucuggguca uguuuuggag                                                   20


<210>  23183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23183
agugagguuc aagacugaag                                                   20


<210>  23184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23184
agacugaagc ugccaagaaa                                                   20


<210>  23185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23185
gucuugaacc ucacuggaag                                                   20


<210>  23186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23186
uggcagcuuc agucuugaac                                                   20


<210>  23187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23187
gagaaucaca cucucuaaaa                                                   20


<210>  23188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23188
cugaagcuuu ucuuggcagc                                                   20


<210>  23189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23189
gggcugaaug cacccucuga                                                   20


<210>  23190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23190
gcccugaaca gggcaaagga                                                   20


<210>  23191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23191
gaacuggaau ucauuugucu                                                   20


<210>  23192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23192
gaacacuggg agugcaccug                                                   20


<210>  23193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23193
aguucugaac acugggagug                                                   20


<210>  23194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23194
uuugucuugg aagaaagugu                                                   20


<210>  23195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23195
aagacaaaug aauuccaguu                                                   20


<210>  23196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23196
uccaagacaa augaauucca                                                   20


<210>  23197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23197
ccuggacggu ucugcacaga                                                   20


<210>  23198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23198
gcacagaauu cauucacaga                                                   20


<210>  23199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23199
gugcagaacc guccaggaga                                                   20


<210>  23200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23200
uucacagagc augucuugga                                                   20


<210>  23201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23201
cagagcaugu cuuggauaua                                                   20


<210>  23202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23202
aaauggguuu ucacagguca                                                   20


<210>  23203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23203
caggucaagg uucugcaggc                                                   20


<210>  23204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23204
gcaggcaaga gcaaauacua                                                   20


<210>  23205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23205
agaggcugau caauagguuu                                                   20


<210>  23206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23206
aucucugugu cucucuggag                                                   20


<210>  23207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23207
cuguagacuc uguggguaaa                                                   20


<210>  23208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23208
ggauauaaaa uaaguaagaa                                                   20


<210>  23209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23209
uacuuauuuu auauccugaa                                                   20


<210>  23210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23210
guaaucugua cacaguuacu                                                   20


<210>  23211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23211
gugaccugcc ucugcaucug                                                   20


<210>  23212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23212
gccaugagug uauuuucugu                                                   20


<210>  23213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23213
uuacgguucu gccaugagug                                                   20


<210>  23214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23214
aggcaacacg uguugcaacc                                                   20


<210>  23215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23215
cuagguugca acacguguug                                                   20


<210>  23216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23216
uucucuaggu ugcaacacgu                                                   20


<210>  23217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23217
caacucaggg gaggcacaaa                                                   20


<210>  23218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23218
ugcuugggac uguugcuccu                                                   20


<210>  23219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23219
cauagcgcug gauugaggau                                                   20


<210>  23220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23220
gauaaauagu auggagauaa                                                   20


<210>  23221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23221
ucaaaaucug acuuaagcaa                                                   20


<210>  23222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23222
acauggauag cuuucaaaaa                                                   20


<210>  23223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23223
aaaacuucua uauugauuug                                                   20


<210>  23224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23224
auauugauuu gauggaauca                                                   20


<210>  23225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23225
aucaaaucaa uauagaaguu                                                   20


<210>  23226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23226
ccaugauucc aucaaaucaa                                                   20


<210>  23227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23227
aaagacuuuc cuauucucuc                                                   20


<210>  23228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23228
uauucucucu cucucccuuu                                                   20


<210>  23229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23229
cucucucucc cuuucuacac                                                   20


<210>  23230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23230
acacacacac aggcacacaa                                                   20


<210>  23231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23231
uacaugcaua uacguaugua                                                   20


<210>  23232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23232
aaaagaguua auaagccuuu                                                   20


<210>  23233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23233
uugccaggca aaacuugaga                                                   20


<210>  23234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23234
caaguuuugc cuggcaauga                                                   20


<210>  23235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23235
aaauguauuu cucaaguuuu                                                   20


<210>  23236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23236
uuuacuugau ugagcuccug                                                   20


<210>  23237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23237
gugccuuggu gauucauuua                                                   20


<210>  23238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23238
agugacuuuc ugugccuugg                                                   20


<210>  23239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23239
agaauugacc aagguuuaag                                                   20


<210>  23240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23240
ugaacguuug ggcuaguuaa                                                   20


<210>  23241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23241
gccagagauc uaaaacuuug                                                   20


<210>  23242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23242
aaguuuuaga ucucuggcug                                                   20


<210>  23243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23243
cauaaauacc ucuccauuau                                                   20


<210>  23244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23244
ugugguccgg agucucucaa                                                   20


<210>  23245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23245
cacuaguucc ugugguccgg                                                   20


<210>  23246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23246
uuuaucaucc gcucccauuu                                                   20


<210>  23247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23247
caaacaaaau augccauggu                                                   20


<210>  23248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23248
uaucaugcau uaacaauaca                                                   20


<210>  23249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23249
cccccaccuc uuauuguguu                                                   20


<210>  23250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23250
cucuucuccc ccaccucuua                                                   20


<210>  23251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23251
uagcccaaug uucucucuuc                                                   20


<210>  23252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23252
ugucugaaua cauaauuuug                                                   20


<210>  23253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23253
gacaugaagu uuaggauuuc                                                   20


<210>  23254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23254
ugccagagau aggugacaaa                                                   20


<210>  23255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23255
gguaauaaug gaaggggaaa                                                   20


<210>  23256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23256
auuauuaccu gaaauaaaag                                                   20


<210>  23257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23257
ccuuccauua uuaccugaaa                                                   20


<210>  23258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23258
uucggccugu uauuugcuuu                                                   20


<210>  23259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23259
gccuguuauu ugcuuuuggg                                                   20


<210>  23260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23260
uuguuuuugu uuuuguuuuu                                                   20


<210>  23261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23261
uuuuucuugu uuuuuaagau                                                   20


<210>  23262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23262
uguuuuuuaa gauuuuauuu                                                   20


<210>  23263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23263
aucucuggua acaaaauaaa                                                   20


<210>  23264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23264
gauuuugcau gcucuucuau                                                   20


<210>  23265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23265
auaaaaaggu aauuuauuua                                                   20


<210>  23266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23266
uuguaggaca caggcacucu                                                   20


<210>  23267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23267
caacugauuc auuugccccu                                                   20


<210>  23268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23268
uuugccccuu acucugagca                                                   20


<210>  23269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23269
uuuauuaucc caugugcuca                                                   20


<210>  23270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23270
aaguuauccu uuggauaaug                                                   20


<210>  23271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23271
gcaugcuucu gaaaacauuu                                                   20


<210>  23272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23272
gaaaacauuu cauaucucau                                                   20


<210>  23273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23273
gaagcaugcu gaaaaagggc                                                   20


<210>  23274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23274
uaucucauuc aaugccacau                                                   20


<210>  23275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23275
augccacaua uaaaugguau                                                   20


<210>  23276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23276
acacugucca gcaaauacca                                                   20


<210>  23277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23277
guuuuccaca cuguccagca                                                   20


<210>  23278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23278
gggacaugcg aucuuugcaa                                                   20


<210>  23279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23279
ucauguaggu aaaagcauau                                                   20


<210>  23280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23280
uuuuuuauuc aucauguagg                                                   20


<210>  23281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23281
cucaauuuau gcugucuuca                                                   20


<210>  23282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23282
acacuaacag agggagaguu                                                   20


<210>  23283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23283
ucuaaacaug uugcaucgga                                                   20


<210>  23284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23284
aaacauguug caucggaugc                                                   20


<210>  23285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23285
uaacuccagg gacucagcau                                                   20


<210>  23286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23286
cuguauggac auagccuaca                                                   20


<210>  23287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23287
uccucccaaa agcugguuuc                                                   20


<210>  23288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23288
uccuuccucc ucccaaaagc                                                   20


<210>  23289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23289
gugauauuuu ccuccuuccu                                                   20


<210>  23290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23290
gucaguuaau ugaauuuaaa                                                   20


<210>  23291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23291
auuaacugac ugaauucagu                                                   20


<210>  23292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23292
aacaaccagg uauuuuaaau                                                   20


<210>  23293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23293
acuauuucuu uuucaaaaac                                                   20


<210>  23294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23294
uuuucaaaaa cguacuucua                                                   20


<210>  23295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23295
aaaacguacu ucuauuuuga                                                   20


<210>  23296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23296
auuuugaugu aguuacauuu                                                   20


<210>  23297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23297
ccaaguuugc uuuuuugggc                                                   20


<210>  23298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23298
uuggaguuuu ucaaaaaaaa                                                   20


<210>  23299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23299
aaaaaaacag cuugcaacaa                                                   20


<210>  23300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23300
ccaucuuuua auuguugcaa                                                   20


<210>  23301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23301
agccuuauaa gauuucucca                                                   20


<210>  23302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23302
gugaauuauc accauuccau                                                   20


<210>  23303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23303
cagaaguuuc cagccuuaua                                                   20


<210>  23304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23304
auuauacugc acuucaauuu                                                   20


<210>  23305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23305
auuuugcuuc cagcaauuug                                                   20


<210>  23306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23306
agcaauuuga aagaugccuu                                                   20


<210>  23307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23307
aauugcugga agcaaaauug                                                   20


<210>  23308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23308
guuggggaau cacgaaucca                                                   20


<210>  23309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23309
ccaacagaaa gcuuaaaggc                                                   20


<210>  23310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23310
ugauucccca acagaaagcu                                                   20


<210>  23311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23311
aucuuugagg caaaucaaga                                                   20


<210>  23312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23312
ugauuugccu caaagaugga                                                   20


<210>  23313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23313
gcugucuuug caggugagcc                                                   20


<210>  23314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23314
gcaacuagau uccaaaaaau                                                   20


<210>  23315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23315
aaaaaauagc agggagaaaa                                                   20


<210>  23316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23316
cccugcuauu uuuuggaauc                                                   20


<210>  23317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23317
uacuaugcua gaacaucaug                                                   20


<210>  23318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23318
agcauaguau gaacaccacu                                                   20


<210>  23319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23319
uugucuugua aaguagguaa                                                   20


<210>  23320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23320
ccuguuagca uuuguuuccu                                                   20


<210>  23321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23321
gacccuuauu guaucaugcu                                                   20


<210>  23322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23322
gaucaguguc ucucuguuaa                                                   20


<210>  23323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23323
ggaaaaucug uaaugcccaa                                                   20


<210>  23324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23324
agaaccaaac uuugacuuuu                                                   20


<210>  23325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23325
ccauggcuuu cacagaaggg                                                   20


<210>  23326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23326
cagaagggua aaugucuacu                                                   20


<210>  23327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23327
gugaaagcca uggagaaauu                                                   20


<210>  23328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23328
aaguagacau uuacccuucu                                                   20


<210>  23329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23329
uccuucauuc guguuuggua                                                   20


<210>  23330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23330
uucauucgug uuugguaauc                                                   20


<210>  23331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23331
uucguguuug guaaucaaaa                                                   20


<210>  23332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23332
uguuugguaa ucaaaaauag                                                   20


<210>  23333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23333
aauugagagc auuaugauaa                                                   20


<210>  23334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23334
uacuacaggc agauacuguu                                                   20


<210>  23335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23335
gguagaggau ggcagcaggg                                                   20


<210>  23336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23336
cagcccugcu gccauccucu                                                   20


<210>  23337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23337
uuuuucccag cccugcugcc                                                   20


<210>  23338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23338
aaccacagua gguuuuuucu                                                   20


<210>  23339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23339
auaacaauga uuucacuuuc                                                   20


<210>  23340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23340
cuuucuagau auaaaacagg                                                   20


<210>  23341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23341
agauauaaaa caggcauggu                                                   20


<210>  23342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23342
cucacccuga acuucugcaa                                                   20


<210>  23343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23343
gggugagaga aaccaugccu                                                   20


<210>  23344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23344
gcaaaaucua gauuugauca                                                   20


<210>  23345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23345
gaaacuggug auuugaucaa                                                   20


<210>  23346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23346
gaauuugauc aaaucuagau                                                   20


<210>  23347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23347
gaaucccaua uuuugggaug                                                   20


<210>  23348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23348
gaauuugauc aaaucaccag                                                   20


<210>  23349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23349
agcagaaagc uauugguugg                                                   20


<210>  23350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23350
gcuagaacac aucaucccaa                                                   20


<210>  23351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23351
uccccaaaag auuuuuaaau                                                   20


<210>  23352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23352
ccaaaagauu uuuaaauagu                                                   20


<210>  23353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23353
ucuuuaaaag gauuucaacu                                                   20


<210>  23354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23354
acuucagauu gugcccacgc                                                   20


<210>  23355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23355
gauugugccc acgccaaagu                                                   20


<210>  23356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23356
caaaugguaa aggauaaaca                                                   20


<210>  23357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23357
aauuauaaau acccauuuaa                                                   20


<210>  23358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23358
uaauccgaga ggaggccuau                                                   20


<210>  23359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23359
agugcagugu gucuauguca                                                   20


<210>  23360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23360
uuaacacccu ccugacauag                                                   20


<210>  23361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23361
ucuuuaacac ccuccugaca                                                   20


<210>  23362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23362
uugcaucuuc uucuuuaaca                                                   20


<210>  23363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23363
cguugucaaa cauuuucauu                                                   20


<210>  23364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23364
ucaugacuuu uacacaguug                                                   20


<210>  23365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23365
uugugacaca cacaacuccc                                                   20


<210>  23366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23366
uaagcgggga acuacuuagc                                                   20


<210>  23367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23367
ccgcuuaaga augcguuggc                                                   20


<210>  23368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23368
uggugcuaag uaguuccccg                                                   20


<210>  23369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23369
aucagguuga aguagaaaua                                                   20


<210>  23370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23370
accugauuga aaugucgacu                                                   20


<210>  23371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23371
acuucaaccu gauugaaaug                                                   20


<210>  23372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23372
auugcucuca ccauucgaua                                                   20


<210>  23373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23373
auauuuauug uagcuuugcc                                                   20


<210>  23374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23374
ggccaagugc cuggaugugg                                                   20


<210>  23375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23375
uuagguaagc acaaauuuga                                                   20


<210>  23376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23376
gccuucguua gguaagcaca                                                   20


<210>  23377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23377
guuucugccu ucguuaggua                                                   20


<210>  23378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23378
uuuucuguuu cugccuucgu                                                   20


<210>  23379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23379
uuuucuuuuu cuguuucugc                                                   20


<210>  23380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23380
cugauuuuca agggaagaga                                                   20


<210>  23381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23381
agggaagaga aggaaaacua                                                   20


<210>  23382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23382
cuugaaaauc agugaaaauc                                                   20


<210>  23383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23383
cuucccuuga aaaucaguga                                                   20


<210>  23384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23384
uucucuuccc uugaaaauca                                                   20


<210>  23385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23385
cucgcucgca cccccuaguu                                                   20


<210>  23386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23386
uauuucccuc gcucgcaccc                                                   20


<210>  23387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23387
aaagccauga uacgccuuuu                                                   20


<210>  23388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23388
gcuuuaucau uucagucuag                                                   20


<210>  23389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23389
gucuaggaga cccagcaaau                                                   20


<210>  23390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23390
cuuccagggu gacaagggag                                                   20


<210>  23391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23391
agggugacaa gggagaacca                                                   20


<210>  23392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23392
cccuugucac ccuggaagag                                                   20


<210>  23393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23393
uugucucuac auacccuugg                                                   20


<210>  23394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23394
cuuggcccuc uucauugucu                                                   20


<210>  23395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23395
cccucacccc uucucuuggc                                                   20


<210>  23396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23396
cacucugucc cggggcaugg                                                   20


<210>  23397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23397
cuuuuacuuc gcacucuguc                                                   20


<210>  23398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23398
cagcagccac cuccauccca                                                   20


<210>  23399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23399
gaguuugagg ugggauggag                                                   20


<210>  23400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23400
uugugaugga ucugaacagc                                                   20


<210>  23401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23401
gauccaucac aaagaaguug                                                   20


<210>  23402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23402
agcagaagga cuuaccaagu                                                   20


<210>  23403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23403
gcuagaacca agggaggcug                                                   20


<210>  23404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23404
acuccuccca cggggccucc                                                   20


<210>  23405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23405
ugcggaggcc ccgugggagg                                                   20


<210>  23406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23406
caacuaccaa augauucuga                                                   20


<210>  23407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23407
gaaauucucu caguggaggu                                                   20


<210>  23408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23408
gaaucauuug guaguugaga                                                   20


<210>  23409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23409
cucaguggag gucuauguua                                                   20


<210>  23410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23410
aauuggccag gcuaacauag                                                   20


<210>  23411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23411
ccauccuuuc aaauuggcca                                                   20


<210>  23412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23412
uguauucucc auccuuucaa                                                   20


<210>  23413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23413
aaaaccaaau guuacuguuu                                                   20


<210>  23414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23414
uugcagaugg auuacacaau                                                   20


<210>  23415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23415
gcaaauauua auagcgucag                                                   20


<210>  23416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23416
gcugcguggu ggccucuccc                                                   20


<210>  23417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23417
ccagaggcaa guuuucagcu                                                   20


<210>  23418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23418
auucaaaacu ucccucaagu                                                   20


<210>  23419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23419
aaacuucccu caaguuucca                                                   20


<210>  23420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23420
cucaaguuuc cagcaugccu                                                   20


<210>  23421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23421
agcaugccuu ccggacuugc                                                   20


<210>  23422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23422
ggacuugccu uaccacagcc                                                   20


<210>  23423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23423
gccagaaaug aaaaccuccu                                                   20


<210>  23424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23424
ggcugaacaa ggcuguggua                                                   20


<210>  23425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23425
uuucuggcug aacaaggcug                                                   20


<210>  23426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23426
aggagguuuu cauuucuggc                                                   20


<210>  23427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23427
ggggggucau aaucugcuuc                                                   20


<210>  23428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23428
uaggacgaug gguucugggg                                                   20


<210>  23429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23429
gauucucccc agccuuugaa                                                   20


<210>  23430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23430
ccccagccuu ugaagguacg                                                   20


<210>  23431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23431
aaggcugggg agaaucagaa                                                   20


<210>  23432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23432
cggaucguac cuucaaaggc                                                   20


<210>  23433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23433
guguguuguc ucuguggcau                                                   20


<210>  23434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23434
uaaaaguccg agcuuaguuu                                                   20


<210>  23435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23435
cauucagccc acugcagucu                                                   20


<210>  23436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23436
gcccacugca gucuccugac                                                   20


<210>  23437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23437
caggacccuc acuugauuuc                                                   20


<210>  23438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23438
ggcucauucu ggacagaugg                                                   20


<210>  23439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23439
ggacagaugg ggaaaugacu                                                   20


<210>  23440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23440
ccaucugucc agaaugagcc                                                   20


<210>  23441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23441
uuacauugca acuuuuccca                                                   20


<210>  23442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23442
caacagcucc gugcuccuuc                                                   20


<210>  23443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23443
auaugcccag aacuggaggg                                                   20


<210>  23444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23444
gggcauauug aaggagcacg                                                   20


<210>  23445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23445
ccuccaguuc ugggcauauu                                                   20


<210>  23446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23446
ucucuuuccc agaagauuga                                                   20


<210>  23447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23447
cuuucccaga agauugaaaa                                                   20


<210>  23448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23448
cagaagauug aaaaacuuga                                                   20


<210>  23449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23449
gggaaagaga agaauguucc                                                   20


<210>  23450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23450
aucuucuggg aaagagaaga                                                   20


<210>  23451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23451
guggucaagu uuuucaaucu                                                   20


<210>  23452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23452
ugcccaguug uugccuggca                                                   20


<210>  23453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23453
gcggugccag gcaacaacug                                                   20


<210>  23454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23454
ucagcggugc caggcaacaa                                                   20


<210>  23455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23455
guacguuugc agcuuucuuc                                                   20


<210>  23456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23456
auccuuuggc cugcggccgc                                                   20


<210>  23457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23457
cugagggucc acaguuguuc                                                   20


<210>  23458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23458
ucaaggguua aaugacuucc                                                   20


<210>  23459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23459
uccucuacca aaugaggcua                                                   20


<210>  23460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23460
uuuccgaggu uguuguggga                                                   20


<210>  23461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23461
gagguuguug ugggauggaa                                                   20


<210>  23462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23462
aucccacaac aaccucggaa                                                   20


<210>  23463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23463
ggaggugcag cccccggagc                                                   20


<210>  23464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23464
cucauuuacu ucucacaugg                                                   20


<210>  23465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23465
cacauggacu cuaugaggua                                                   20


<210>  23466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23466
cagagaggug aaaugauucc                                                   20


<210>  23467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23467
ccucucugug aaauggagau                                                   20


<210>  23468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23468
cucagacucu cccaaccagc                                                   20


<210>  23469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23469
auguuacugc uagcugguug                                                   20


<210>  23470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23470
gauuucuaug uuacugcuag                                                   20


<210>  23471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23471
gguggcagcu cccucguggg                                                   20


<210>  23472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23472
cucaucccaa ccugcucacc                                                   20


<210>  23473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23473
cccauuaugg ggugagcagg                                                   20


<210>  23474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23474
aagccaugag ucauaaccgu                                                   20


<210>  23475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23475
ccccacuuua cagauugagg                                                   20


<210>  23476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23476
ucaaucugua aaguggggag                                                   20


<210>  23477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23477
cuaagccucc gcuuccucaa                                                   20


<210>  23478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23478
uucccuaagc cuccgcuucc                                                   20


<210>  23479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23479
aguugugcaa ccuugggcag                                                   20


<210>  23480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23480
uuacccucag ccuaaaccau                                                   20


<210>  23481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23481
uguaaucaaa gagaagaaga                                                   20


<210>  23482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23482
cuuugauuac acgaaauaaa                                                   20


<210>  23483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23483
ucucuuugau uacacgaaau                                                   20


<210>  23484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23484
ucuucucuuu gauuacacga                                                   20


<210>  23485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23485
uuucuucuuc ucuuugauua                                                   20


<210>  23486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23486
uucuuuucuu cuucucuuug                                                   20


<210>  23487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23487
ccucuuucug ucccuccucc                                                   20


<210>  23488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23488
gucccuccuc ccuuucuuac                                                   20


<210>  23489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23489
uaccagcuca gguuacaaag                                                   20


<210>  23490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23490
cucccaccua gaugucuuug                                                   20


<210>  23491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23491
caguuuuuau uugcuacuag                                                   20


<210>  23492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23492
aguagcaaau aaaaacuggg                                                   20


<210>  23493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23493
ccuuuucuag uagcaaauaa                                                   20


<210>  23494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23494
uucuccuuuu cuaguagcaa                                                   20


<210>  23495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23495
ccuggcuagg ccucauaagg                                                   20


<210>  23496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23496
agucuaugau gggaaaaaua                                                   20


<210>  23497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23497
caucauagac uugaaaaggc                                                   20


<210>  23498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23498
cacaauaaaa aauauuuuuc                                                   20


<210>  23499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23499
gacagguccc caaaccacuu                                                   20


<210>  23500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23500
agugguuugg ggaccugucu                                                   20


<210>  23501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23501
augaacccag cuuuagcccc                                                   20


<210>  23502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23502
uagaauccca ccuaggggac                                                   20


<210>  23503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23503
caccagagga gcugcugggg                                                   20


<210>  23504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23504
aguucccacc agaggagcug                                                   20


<210>  23505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23505
cuguuacuaa cuggcaggag                                                   20


<210>  23506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23506
auuacuucgc cacuuguggc                                                   20


<210>  23507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23507
ccacuugugg caggagggca                                                   20


<210>  23508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23508
ugacauuuuu agcucuuuua                                                   20


<210>  23509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23509
uauaugaaug cauaauguca                                                   20


<210>  23510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23510
uauaugaaug uuggcaagca                                                   20


<210>  23511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23511
uguguuuuuu aguuuauugu                                                   20


<210>  23512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23512
uggccucuuc cuguguuuuu                                                   20


<210>  23513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23513
uaucuucuug gccucuuccu                                                   20


<210>  23514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23514
cgauuuucuu aucuucuugg                                                   20


<210>  23515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23515
ugggcaggac ccaggaccga                                                   20


<210>  23516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23516
ccaccccugg ccuuucuuga                                                   20


<210>  23517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23517
ugagccuucc uugagccuuc                                                   20


<210>  23518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23518
uugagccuuc cuugcauauu                                                   20


<210>  23519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23519
uugcauauua ucguucucag                                                   20


<210>  23520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23520
cagccaccga cagcuuaauu                                                   20


<210>  23521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23521
caggcccuuc caacaaguua                                                   20


<210>  23522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23522
aacaaguuaa acuucagcca                                                   20


<210>  23523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23523
gccauuuaaa aaaaaaaaaa                                                   20


<210>  23524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23524
acugauuucu uaccugcaca                                                   20


<210>  23525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23525
uaccugcaca cgcaggcacg                                                   20


<210>  23526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23526
ggcgaccagg ugugagagcu                                                   20


<210>  23527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23527
caucuggccc ucggguuacu                                                   20


<210>  23528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23528
caacggcaag ccaggaaaga                                                   20


<210>  23529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23529
uggcuugccg uugggaaaaa                                                   20


<210>  23530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23530
aucaucuuuc cuggcuugcc                                                   20


<210>  23531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23531
gaggagggaa aaaauugagc                                                   20


<210>  23532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23532
cuccucugaa ccaguugagg                                                   20


<210>  23533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23533
uuuuuaaaua ccugcugacu                                                   20


<210>  23534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23534
uucuuuuuua aauaccugcu                                                   20


<210>  23535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23535
uucuuucuuu uuuaaauacc                                                   20


<210>  23536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23536
uuuuucuuuc uuucuuuuuu                                                   20


<210>  23537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23537
guguuuuuuu uuuccuuuuu                                                   20


<210>  23538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23538
ucuguuaaug gacaaccaca                                                   20


<210>  23539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23539
cuguucuccu accucuuucg                                                   20


<210>  23540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23540
ccuaccucuu ucgagcuccu                                                   20


<210>  23541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23541
agcuccuaaa aacuagacau                                                   20


<210>  23542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23542
cuuucuauuc aagauaaaca                                                   20


<210>  23543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23543
auucaagaua aacaaagugc                                                   20


<210>  23544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23544
agauaaacaa agugcuucaa                                                   20


<210>  23545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23545
aguucagggc gcacccuggg                                                   20


<210>  23546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23546
gggcgcaccc ugggaccccu                                                   20


<210>  23547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23547
gucugcuaaa ccagucuggc                                                   20


<210>  23548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23548
cuuugugcuc cuucccucuu                                                   20


<210>  23549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23549
cucuugccac uaaccucuuu                                                   20


<210>  23550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23550
uuaccaccuu cuccggagca                                                   20


<210>  23551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23551
ccggagcaga uggacuugac                                                   20


<210>  23552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23552
gagguugcca ggaggggcuu                                                   20


<210>  23553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23553
cuaauuucug agguugccag                                                   20


<210>  23554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23554
ccucccucug uguugcccga                                                   20


<210>  23555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23555
guggguccaa cgggauuugu                                                   20


<210>  23556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23556
acccucucac acuaacacua                                                   20


<210>  23557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23557
gguuuagugu uagugugaga                                                   20


<210>  23558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23558
gcaagaauau uuuaagugag                                                   20


<210>  23559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23559
ugcagaacgc aaaggagggg                                                   20


<210>  23560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23560
guacugguug uaaaaagugu                                                   20


<210>  23561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23561
uuaauauuau uuauuaugua                                                   20


<210>  23562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23562
uaagccuugg ccagggcuuu                                                   20


<210>  23563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23563
ugcaagggga aaguccagcc                                                   20


<210>  23564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23564
ccuugcauga aauaauaaaa                                                   20


<210>  23565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23565
uuggcuggac uuuccccuug                                                   20


<210>  23566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23566
gccuuuccau guggucggga                                                   20


<210>  23567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23567
auguggucgg gaaguuaccc                                                   20


<210>  23568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23568
cgaccacaug gaaaggcuga                                                   20


<210>  23569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23569
cucuuccuaa ccacccucuc                                                   20


<210>  23570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23570
uaaccacccu cucugccggc                                                   20


<210>  23571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23571
gucagugucc acccugcccc                                                   20


<210>  23572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23572
uuuguccuuu gaggggcagg                                                   20


<210>  23573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23573
cacugggucu gggggauuuc                                                   20


<210>  23574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23574
uuuagguggg cuuauuuccc                                                   20


<210>  23575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23575
ucauuuaggu gggcuuauuu                                                   20


<210>  23576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23576
gagccuuaac ccagaugcuc                                                   20


<210>  23577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23577
aacgcuggug caggauuccg                                                   20


<210>  23578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23578
ugccacaccg ccgggccccu                                                   20


<210>  23579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23579
auugugcggu ggguguguug                                                   20


<210>  23580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23580
ugaucuuaau uagauucgau                                                   20


<210>  23581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23581
uccugaucuu aauuagauuc                                                   20


<210>  23582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23582
uuucacugua cccccaguaa                                                   20


<210>  23583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23583
cuguaccccc aguaaucaca                                                   20


<210>  23584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23584
gugauuacug gggguacagu                                                   20


<210>  23585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23585
ucaaauuuug agaauuuugu                                                   20


<210>  23586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23586
aauuuugaga auuuuguucc                                                   20


<210>  23587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23587
caaaauuuga agaacuucug                                                   20


<210>  23588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23588
ucugcuaauu auuucccuca                                                   20


<210>  23589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23589
cucauuuugc auuucaaggc                                                   20


<210>  23590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23590
aggcacaaag acagucuauc                                                   20


<210>  23591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23591
aacuauuaau agaccaccag                                                   20


<210>  23592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23592
gacgcucaaa acuucaaacu                                                   20


<210>  23593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23593
uuuuaaaacu auucugucau                                                   20


<210>  23594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23594
gucauuucca guuuuuuaaa                                                   20


<210>  23595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23595
aguuuuuuaa aaagguuuug                                                   20


<210>  23596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23596
uuuuuuggug gugguggcgu                                                   20


<210>  23597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23597
ucagaaagac agcuucuggg                                                   20


<210>  23598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23598
gaaagacagc uucugggcca                                                   20


<210>  23599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23599
gaagaaacau uaacgccacc                                                   20


<210>  23600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23600
gggccacucu ggguauuaug                                                   20


<210>  23601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23601
cccuuacaau aguuacucuc                                                   20


<210>  23602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23602
guaaaucagu aaaccaggca                                                   20


<210>  23603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23603
cauaccaagg uucuguaaau                                                   20


<210>  23604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23604
ccauucacau accaagguuc                                                   20


<210>  23605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23605
uuuucgccau ucacauacca                                                   20


<210>  23606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23606
uuuuuuuucu uuuucgccau                                                   20


<210>  23607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23607
uuccuuuuuu uucuuuuucg                                                   20


<210>  23608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23608
uuuuuucuuu ccuuuuuuuu                                                   20


<210>  23609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23609
uuggcauaag gauauguuug                                                   20


<210>  23610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23610
gaucaugugu uguucauuau                                                   20


<210>  23611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23611
uuauuaugac uuuacuugaa                                                   20


<210>  23612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23612
aguaaaguca uaauaaugaa                                                   20


<210>  23613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23613
cuuauaugcu uucuaccccu                                                   20


<210>  23614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23614
accccuccac ucccuuuaag                                                   20


<210>  23615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23615
aaaaacagua caauuuuuuu                                                   20


<210>  23616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23616
aaguacuuaa agggagugga                                                   20


<210>  23617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23617
ccaucuguaa auucccugaa                                                   20


<210>  23618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23618
cugaaaauac auuuucaaaa                                                   20


<210>  23619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23619
gggaauuuac agauggugaa                                                   20


<210>  23620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23620
aaagacuuau gcaaagccac                                                   20


<210>  23621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23621
aaaucaugug gcuuugcaua                                                   20


<210>  23622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23622
uaagucacca uuaaauuuug                                                   20


<210>  23623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23623
aauacuuuuu auuuacuucc                                                   20


<210>  23624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23624
uguagaauua uuuguguacu                                                   20


<210>  23625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23625
acaggaagua aauaaaaagu                                                   20


<210>  23626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23626
ccauuauaua acaaucuacc                                                   20


<210>  23627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23627
aauagauugg cauaaucuag                                                   20


<210>  23628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23628
uucuaauaga uuggcauaau                                                   20


<210>  23629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23629
gcuuauaugg aguacaaauu                                                   20


<210>  23630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23630
agucacuuuu gacuuaccau                                                   20


<210>  23631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23631
auguaaagug uuauuauagc                                                   20


<210>  23632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23632
ugcugcuucu agggcugugu                                                   20


<210>  23633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23633
agggcugugu caguguuuac                                                   20


<210>  23634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23634
uggaaguuaa auaaaccgac                                                   20


<210>  23635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23635
aggaauguaa acacugacac                                                   20


<210>  23636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23636
gucuauccag gaguuuugcc                                                   20


<210>  23637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23637
uguaaaguuu gggggagaga                                                   20


<210>  23638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23638
cuccucucuc ucucccccaa                                                   20


<210>  23639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23639
cucuuucucu ccucucucuc                                                   20


<210>  23640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23640
uucucucuuu cucuccucuc                                                   20


<210>  23641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23641
uuccuucucu cuuucucucc                                                   20


<210>  23642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23642
aucuugcauc acccccuuca                                                   20


<210>  23643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23643
auaugucaca aagaccuucc                                                   20


<210>  23644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23644
uauccacagc caacgcgacu                                                   20


<210>  23645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23645
gucgcguugg cuguggauag                                                   20


<210>  23646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23646
uaaauaccgg gucagcugaa                                                   20


<210>  23647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23647
gcugacccgg uauuuaagaa                                                   20


<210>  23648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23648
ccacugccca cucagcccca                                                   20


<210>  23649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23649
uacuuuaugu ggggcugagu                                                   20


<210>  23650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23650
aauagcaaau uauccauuag                                                   20


<210>  23651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23651
ucauaucuua guaaagcaau                                                   20


<210>  23652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23652
ugauguaauu gcuuuacuaa                                                   20


<210>  23653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23653
acacgcacua ucauuuucuu                                                   20


<210>  23654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23654
cagccuuugg ucuccggcca                                                   20


<210>  23655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23655
gcccucuccg acuucacagc                                                   20


<210>  23656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23656
ucuuacugcc uaaaaaguuc                                                   20


<210>  23657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23657
ugcacuuaau aauuuauuug                                                   20


<210>  23658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23658
ggauacuguu ucccagcuga                                                   20


<210>  23659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23659
cagcugaaua uuaacaacuu                                                   20


<210>  23660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23660
gcugggaaac aguauccaga                                                   20


<210>  23661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23661
guuuaaaguu guuaauauuc                                                   20


<210>  23662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23662
auccauacca ugcuaaaagc                                                   20


<210>  23663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23663
uacacacugu ucauuuucca                                                   20


<210>  23664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23664
uuuuccauca caauuuauuu                                                   20


<210>  23665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23665
aucacaauuu auuuucuuuc                                                   20


<210>  23666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23666
uucauuaaac auucguuuua                                                   20


<210>  23667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23667
uuaaacauuc guuuuaauca                                                   20


<210>  23668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23668
uuuuaaucag aauaucaguu                                                   20


<210>  23669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23669
gauuaaaacg aauguuuaau                                                   20


<210>  23670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23670
gauucugcuu guuaaccagu                                                   20


<210>  23671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23671
gcuuguuaac cagugauaaa                                                   20


<210>  23672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23672
ucuuugguuu augaguuuau                                                   20


<210>  23673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23673
acagcaaagg caaacaccaa                                                   20


<210>  23674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23674
gauuuuugag agccugugau                                                   20


<210>  23675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23675
ccaccagggc acucguguac                                                   20


<210>  23676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23676
gcugcugcuc ugagcuacaa                                                   20


<210>  23677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23677
cauucagcug cugcucugag                                                   20


<210>  23678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23678
uuagauagau ggcuggcacc                                                   20


<210>  23679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23679
ucuuuagaua gauggcuggc                                                   20


<210>  23680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23680
aacaaugcuu uagguuucuu                                                   20


<210>  23681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23681
guagccuucc cuccuccaaa                                                   20


<210>  23682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23682
cuccuccaaa ggaggaaccu                                                   20


<210>  23683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23683
uccuuuggag gagggaaggc                                                   20


<210>  23684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23684
ugccaucaaa cugcuaacaa                                                   20


<210>  23685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23685
uggggaacag aaacaggcaa                                                   20


<210>  23686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23686
ccacgaacau ugcagggcag                                                   20


<210>  23687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23687
guuccccacg aacauugcag                                                   20


<210>  23688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23688
cuauguaucu ggaagugccu                                                   20


<210>  23689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23689
agauacauag agaaauaugu                                                   20


<210>  23690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23690
ccccaaauga gaacgauuuc                                                   20


<210>  23691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23691
cauuugggga gaagacugua                                                   20


<210>  23692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23692
agccaacacg uucacaaacu                                                   20


<210>  23693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23693
caaacuguac uuaacguuaa                                                   20


<210>  23694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23694
uuuaacguua aguacaguuu                                                   20


<210>  23695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23695
aauuccucaa uucacuaaag                                                   20


<210>  23696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23696
ucaauucacu aaaggaaacu                                                   20


<210>  23697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23697
cuaaaggaaa cuuggcaaga                                                   20


<210>  23698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23698
uuuagugaau ugaggaauua                                                   20


<210>  23699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23699
ugccaaguuu ccuuuaguga                                                   20


<210>  23700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23700
acuggggcau cugaggagga                                                   20


<210>  23701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23701
uaugcaaauu acauuaauga                                                   20


<210>  23702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23702
uuaauguaau uugcauauga                                                   20


<210>  23703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23703
ccaagagauu ugacauauuu                                                   20


<210>  23704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23704
caagauuaaa aguucaccaa                                                   20


<210>  23705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23705
ucucaagauu aaaaguucac                                                   20


<210>  23706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23706
aucuugcaaa auugaugaug                                                   20


<210>  23707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23707
uagauuuuca aucuugcaaa                                                   20


<210>  23708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23708
ccuuuuuuuu cuccuucagc                                                   20


<210>  23709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23709
ccuucagcag gcugacaggc                                                   20


<210>  23710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23710
gcaggcugac aggccagccu                                                   20


<210>  23711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23711
gugcacauca ggcuggccug                                                   20


<210>  23712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23712
caauuacugg aaggaccuaa                                                   20


<210>  23713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23713
aguaauugcg aauuguuuug                                                   20


<210>  23714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23714
aaugaccauu agguccuucc                                                   20


<210>  23715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23715
uuaccuaguu guaaauucua                                                   20


<210>  23716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23716
guucauuacc uaguuguaaa                                                   20


<210>  23717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23717
uaaagcaauu uagccuuuga                                                   20


<210>  23718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23718
aaggcuaaau ugcuuuauga                                                   20


<210>  23719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23719
uuaaucuuca aaggcuaaau                                                   20


<210>  23720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23720
aaugagcuuu agcaaauuau                                                   20


<210>  23721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23721
uccaaaaagc aaaggguuuu                                                   20


<210>  23722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23722
uccuaugauu uccucauuuu                                                   20


<210>  23723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23723
uaugauuucc ucauuuuuuu                                                   20


<210>  23724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23724
ucauuuuuuu aaugcaaaau                                                   20


<210>  23725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23725
agacugagcu uaaacuaaac                                                   20


<210>  23726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23726
agucaagcca aaggggcuaa                                                   20


<210>  23727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23727
uaaaacuaag cccuuaagag                                                   20


<210>  23728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23728
guuggaggac uaugcaguau                                                   20


<210>  23729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23729
aaaaagccuu uucccccuca                                                   20


<210>  23730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23730
cccucaaguu gucucuccug                                                   20


<210>  23731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23731
uuggcuugga guggcauuaa                                                   20


<210>  23732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23732
aaaauuaaug ccacuccaag                                                   20


<210>  23733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23733
gcuuccaaag ggaaaccagc                                                   20


<210>  23734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23734
aaagggaaac cagcaagaaa                                                   20


<210>  23735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23735
cuuuggaagc agaaacuucu                                                   20


<210>  23736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23736
ugcugguuuc ccuuuggaag                                                   20


<210>  23737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23737
ccuuucuugc ugguuucccu                                                   20


<210>  23738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23738
gaggagugca aauccuguug                                                   20


<210>  23739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23739
gauuuccucc auucggcacc                                                   20


<210>  23740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23740
uccauucggc accagccgca                                                   20


<210>  23741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23741
gcaccagccg cauuuaaucc                                                   20


<210>  23742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23742
ccauggauua aaugcggcug                                                   20


<210>  23743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23743
gaaaguugug guguccaccc                                                   20


<210>  23744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23744
gaaugucagc ugaugucugc                                                   20


<210>  23745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23745
cacgauacuc ucuaauaacu                                                   20


<210>  23746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23746
aauuacuagu cuggagaaga                                                   20


<210>  23747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23747
ccagacuagu aauuggaaag                                                   20


<210>  23748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23748
ucuccagacu aguaauugga                                                   20


<210>  23749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23749
agcaaaggau ucuucuccag                                                   20


<210>  23750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23750
agugacagaa uucccaauga                                                   20


<210>  23751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23751
gucacuagaa uuuuuuaaau                                                   20


<210>  23752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23752
caaugaacuc cuccucuucc                                                   20


<210>  23753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23753
uugggaauuc ugucacuaga                                                   20


<210>  23754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23754
ucccaacccc aaccucucca                                                   20


<210>  23755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23755
ccuggguugg agagguuggg                                                   20


<210>  23756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23756
ugcuuucacc uggguuggag                                                   20


<210>  23757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23757
cagucugacu ugcacaccag                                                   20


<210>  23758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23758
aaaggccacg ugucccagcu                                                   20


<210>  23759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23759
aagcuguuau ucucagucug                                                   20


<210>  23760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23760
uuugaacugc uaucgaagaa                                                   20


<210>  23761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23761
aaugaaaucc ccacagcaga                                                   20


<210>  23762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23762
auagcaguuc aaaugaaauc                                                   20


<210>  23763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23763
ucgauagcag uucaaaugaa                                                   20


<210>  23764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23764
aagaaccucu cuccgcaccc                                                   20


<210>  23765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23765
uggaauauuc uucgauagca                                                   20


<210>  23766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23766
cccccucucu cccccagccu                                                   20


<210>  23767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23767
ccuagaguug aucuuaccgg                                                   20


<210>  23768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23768
gguaagauca acucuaggag                                                   20


<210>  23769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23769
uugauaacau ccacauuucc                                                   20


<210>  23770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23770
gauuuccuug auaacaucca                                                   20


<210>  23771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23771
cuuuccgauu uccuugauaa                                                   20


<210>  23772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23772
cccuucucuu uccgauuucc                                                   20


<210>  23773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23773
uaacucucuu auccuugggc                                                   20


<210>  23774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23774
gagcagggcc caaggauaag                                                   20


<210>  23775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23775
aauaaauguu aaaauguggc                                                   20


<210>  23776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23776
augcagcucu gcauccuauc                                                   20


<210>  23777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23777
guuugacacu aauguuacuc                                                   20


<210>  23778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23778
augaggguug auaugggaug                                                   20


<210>  23779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23779
gauuugcccu gucacauccc                                                   20


<210>  23780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23780
aaacuuuugu uuuuaaucua                                                   20


<210>  23781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23781
agucccauuu gcucuguagu                                                   20


<210>  23782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23782
ccuaacugcc uucaagugau                                                   20


<210>  23783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23783
agugauuuuc ccuauuagag                                                   20


<210>  23784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23784
cuauuagagc guuugccugc                                                   20


<210>  23785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23785
gaugugauug cgguguugcc                                                   20


<210>  23786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23786
acuuuacuuu cugaugugau                                                   20


<210>  23787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23787
uauaugcauu ccacuuuacu                                                   20


<210>  23788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23788
ucuuuaaaua caauaccuau                                                   20


<210>  23789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23789
ggucagcagu gugcaggcag                                                   20


<210>  23790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23790
gcugcugaca gcaggcauug                                                   20


<210>  23791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23791
uguauaaaaa uaauucagcu                                                   20


<210>  23792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23792
acauacaagu ggauugcuua                                                   20


<210>  23793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23793
uucuugcuac cagucacaca                                                   20


<210>  23794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23794
ugcuaccagu cacacagcuc                                                   20


<210>  23795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23795
gaucuuggag cugugugacu                                                   20


<210>  23796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23796
ucugaucuug gagcugugug                                                   20


<210>  23797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23797
aagacuaugu auuucuucug                                                   20


<210>  23798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23798
aagauccaag aguaucuuua                                                   20


<210>  23799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23799
gauaaagaua cucuuggauc                                                   20


<210>  23800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23800
uuauugauuu uuuucuccuu                                                   20


<210>  23801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23801
ccuuaacaua acaaaaacau                                                   20


<210>  23802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23802
cauguuaugu uuuuguuaug                                                   20


<210>  23803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23803
gccuuuaaau cauucuucag                                                   20


<210>  23804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23804
ucaguagcca auguucaguu                                                   20


<210>  23805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23805
guagccaaug uucaguuuua                                                   20


<210>  23806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23806
guuuuaaaug uaaaggaaua                                                   20


<210>  23807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23807
uuuacauuua aaacugaaca                                                   20


<210>  23808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23808
cuccaucaca cccuaauauu                                                   20


<210>  23809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23809
aguuaaaaca augcauuaac                                                   20


<210>  23810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23810
guuuccaguu aaaacaaugc                                                   20


<210>  23811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23811
cugagggguu ccccccuaaa                                                   20


<210>  23812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23812
ccccuaaaug uaaauaaauc                                                   20


<210>  23813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23813
ccaacucaag guauaccaug                                                   20


<210>  23814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23814
ccuucaccaa cucaagguau                                                   20


<210>  23815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23815
gguuugguuc ucuuaguuuu                                                   20


<210>  23816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23816
cuuaguuuuu ugagguuugu                                                   20


<210>  23817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23817
uguacauuuu aaauauagag                                                   20


<210>  23818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23818
uauguuggag cacaaagcac                                                   20


<210>  23819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23819
cuaaaaauua acagauguga                                                   20


<210>  23820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23820
uugcagccuu uuuaugcauc                                                   20


<210>  23821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23821
uaauauguaa ugaugcauaa                                                   20


<210>  23822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23822
uuuucuuaau auguaaugau                                                   20


<210>  23823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23823
ucaguuguuc auuuucuuaa                                                   20


<210>  23824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23824
uuguguuuuu uagaaaguuc                                                   20


<210>  23825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23825
aaaaaacaca aggaagcuuu                                                   20


<210>  23826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23826
aaaagcaaau agaaaggcga                                                   20


<210>  23827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23827
auuugcuuuu ugaacuuucu                                                   20


<210>  23828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23828
uuuugaaggc acccuugcag                                                   20


<210>  23829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23829
aaaagaaaac cagugcuguu                                                   20


<210>  23830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23830
caauaauucc auucuuuauu                                                   20


<210>  23831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23831
auucuuuauu uuaaugggag                                                   20


<210>  23832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23832
uuauuuuaau gggaguuuuu                                                   20


<210>  23833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23833
ccucuaucua aaacuaaaau                                                   20


<210>  23834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23834
uuggcaaugc uaacaacagu                                                   20


<210>  23835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23835
cacuguuguu agcauugcca                                                   20


<210>  23836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23836
ucaacauacc ugcuccaggu                                                   20


<210>  23837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23837
cacugggaau ucucuggcag                                                   20


<210>  23838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23838
cagugggaac cuggagcagg                                                   20


<210>  23839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23839
cuggcagaga cugauucagu                                                   20


<210>  23840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23840
guucugaaua acaugcugcc                                                   20


<210>  23841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23841
gaauaacaug cugccagccc                                                   20


<210>  23842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23842
gaacugaauc agucucugcc                                                   20


<210>  23843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23843
agauagggcu ggcagcaugu                                                   20


<210>  23844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23844
cgccucuuuu acaggaaguu                                                   20


<210>  23845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23845
uguaaaagag gcgagaaggc                                                   20


<210>  23846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23846
cagagugcua aacaacaaau                                                   20


<210>  23847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23847
agcagcauug caucagaucc                                                   20


<210>  23848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23848
cccuggagac ugaugugagu                                                   20


<210>  23849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23849
guucccuguc ugcaaacuuc                                                   20


<210>  23850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23850
cugucugcaa acuucuaauu                                                   20


<210>  23851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23851
aauucgccag uucuuagcag                                                   20


<210>  23852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23852
ccaguucuua gcagcuuauu                                                   20


<210>  23853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23853
uagcagcuua uuuuuccaag                                                   20


<210>  23854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23854
aaguguuuug uuucaggaaa                                                   20


<210>  23855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23855
ggaaacgugu auuuuucuuu                                                   20


<210>  23856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23856
ugaaacaaaa cacuuggaaa                                                   20


<210>  23857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23857
uuauacguuu uguggaucua                                                   20


<210>  23858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23858
gacagcuguu gauucuguua                                                   20


<210>  23859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23859
guuaaaggaa cacauuauaa                                                   20


<210>  23860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23860
uuuaacagaa ucaacagcug                                                   20


<210>  23861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23861
uuaaaaccuc aagcaaugug                                                   20


<210>  23862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23862
ccauuauauu uuugagucca                                                   20


<210>  23863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23863
auuaaaauau uucaccauua                                                   20


<210>  23864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23864
aguugaaagu uguuuuuuaa                                                   20


<210>  23865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23865
acuggaauuc cauuaaaaua                                                   20


<210>  23866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23866
uuuguacuuu uuuuaaaaaa                                                   20


<210>  23867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23867
guaccuucau uuguacuuuu                                                   20


<210>  23868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23868
guuuaaaucu aguacugauc                                                   20


<210>  23869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23869
ccauuacaca cacacacaca                                                   20


<210>  23870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23870
aaucacauac uuuuaacggg                                                   20


<210>  23871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23871
cguuaaaagu augugauuug                                                   20


<210>  23872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23872
agcuuuuccc guuaaaagua                                                   20


<210>  23873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23873
aacgccugua auuaaccaua                                                   20


<210>  23874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23874
uaugguuaau uacaggcguu                                                   20


<210>  23875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23875
ccauaccagc acaugcaaaa                                                   20


<210>  23876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23876
gguggugaau ugggaggugg                                                   20


<210>  23877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23877
ccaccagaau uuuuuugcau                                                   20


<210>  23878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23878
cuuggaguug ucuccccaac                                                   20


<210>  23879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23879
ucucuuggag uugucucccc                                                   20


<210>  23880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23880
uuucgcuaua gaucaaagga                                                   20


<210>  23881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23881
cuauagauca aaggagaaca                                                   20


<210>  23882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23882
ccuuugaucu auagcgaaau                                                   20


<210>  23883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23883
uguucuccuu ugaucuauag                                                   20


<210>  23884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23884
auucuuguuc uccuuugauc                                                   20


<210>  23885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23885
auugcugucu uucacacugg                                                   20


<210>  23886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23886
cacugggcua ucuaaguuua                                                   20


<210>  23887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23887
ccagacuagc ugcauauuaa                                                   20


<210>  23888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23888
accaccacac cauaauaaag                                                   20


<210>  23889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23889
uccaccacca caccauaaua                                                   20


<210>  23890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23890
agcuccgcau cugacagggc                                                   20


<210>  23891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23891
uuugccuuua caauaggcgc                                                   20


<210>  23892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23892
cugcugggau cagaagugac                                                   20


<210>  23893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23893
gaucccagca gggaauaggu                                                   20


<210>  23894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23894
cuugccaacc uaacucaaug                                                   20


<210>  23895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23895
gcaauggcau ugaguuaggu                                                   20


<210>  23896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23896
ucauucugca auggcauuga                                                   20


<210>  23897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23897
gagcucauuc gucauucugc                                                   20


<210>  23898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23898
uagcaggguu aguaacuugg                                                   20


<210>  23899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23899
gcaaaggcuu uugcuguucu                                                   20


<210>  23900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23900
aaugaaccca auauggaaua                                                   20


<210>  23901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23901
uuggaauuug ucucccugcu                                                   20


<210>  23902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23902
auauuggguu cauuggaauu                                                   20


<210>  23903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23903
aaucaguuuu aaaauguaac                                                   20


<210>  23904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23904
aauugaguuu ggcaucaagu                                                   20


<210>  23905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23905
uuagcucucu acaugugcuc                                                   20


<210>  23906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23906
uauuugucag guuacauuuc                                                   20


<210>  23907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23907
uggaaauuaa guuugugaca                                                   20


<210>  23908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23908
aggaaaugua accugacaaa                                                   20


<210>  23909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23909
gucacaaacu uaauuuccag                                                   20


<210>  23910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23910
ugcucaaauu aauuagguca                                                   20


<210>  23911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23911
ccccuuuacg accaggguau                                                   20


<210>  23912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23912
ccuaccuagg uaaaugggca                                                   20


<210>  23913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23913
uuucuccuac cuagguaaau                                                   20


<210>  23914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23914
uauuuguauu acaaauaaaa                                                   20


<210>  23915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23915
gacuauauaa uuuaauggau                                                   20


<210>  23916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23916
uaaaauaugu ucagacuaua                                                   20


<210>  23917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23917
uuaaugucau ccaaauugau                                                   20


<210>  23918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23918
aaucaagcag guuuuuaugu                                                   20


<210>  23919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23919
aacuuagagc ccacuuuuaa                                                   20


<210>  23920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23920
aggauuaaaa aaaaagauuc                                                   20


<210>  23921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23921
uuugggucau ggcuauguca                                                   20


<210>  23922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23922
gauuucauuu gggucauggc                                                   20


<210>  23923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23923
gcuuguucag auuucauuug                                                   20


<210>  23924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23924
uugugcaaua aaggguguga                                                   20


<210>  23925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23925
cacccuuuau ugcacaaaga                                                   20


<210>  23926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23926
acuucgguua aauuuaauau                                                   20


<210>  23927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23927
guuaaauuua auauuucccc                                                   20


<210>  23928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23928
ccccaaagga aagccaaaau                                                   20


<210>  23929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23929
uuugggggga aauauuaaau                                                   20


<210>  23930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23930
uuucuuacug accagcacgc                                                   20


<210>  23931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23931
uacugaccag cacgcaaagc                                                   20


<210>  23932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23932
ccuauucucc uuuauuaaac                                                   20


<210>  23933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23933
ccuuuauuaa acauuuucau                                                   20


<210>  23934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23934
uugagaaauc acaaaaaucu                                                   20


<210>  23935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23935
caaugaaaau guuuaauaaa                                                   20


<210>  23936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23936
cuaggauuug cauguuuuuu                                                   20


<210>  23937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23937
auguaguuug gcuaaugugg                                                   20


<210>  23938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23938
cacugcagcu uccauguagu                                                   20


<210>  23939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23939
aggacucuaa aagaugccau                                                   20


<210>  23940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23940
gcucagggag gaggcgaguu                                                   20


<210>  23941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23941
acacccaguu gcauuuucca                                                   20


<210>  23942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23942
agcccaugug cagcuccaca                                                   20


<210>  23943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23943
cuaagagaaa ggugugcaaa                                                   20


<210>  23944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23944
cuuagugaau guggcauaua                                                   20


<210>  23945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23945
gauccuuuau aguaaaggca                                                   20


<210>  23946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23946
uuguuguguu gcaaguugug                                                   20


<210>  23947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23947
uaaaucaccc cauuccuugu                                                   20


<210>  23948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23948
cagaauaaac acagagaacg                                                   20


<210>  23949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23949
gugaaagcuu aaaaaaacaa                                                   20


<210>  23950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23950
cuguguuuau ucugugaaag                                                   20


<210>  23951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23951
cucccguucu cuguguuuau                                                   20


<210>  23952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23952
ugaagugaau acauauuugu                                                   20


<210>  23953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23953
agaacaggag cagaggggga                                                   20


<210>  23954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23954
cuucaagaac aggagcagag                                                   20


<210>  23955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23955
aauaaaaggc cauuuuuaca                                                   20


<210>  23956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23956
gucuccugcu guuacagaca                                                   20


<210>  23957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23957
uaucacgugg accuauucuc                                                   20


<210>  23958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23958
caaaacauua uuuauaaaag                                                   20


<210>  23959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23959
uagucaucuu uuauaaauaa                                                   20


<210>  23960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23960
gugucaccac aaggguaaug                                                   20


<210>  23961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23961
gacauuaccc uuguggugac                                                   20


<210>  23962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23962
ucagacauua cccuuguggu                                                   20


<210>  23963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23963
acauuuuaga uauauuuuuu                                                   20


<210>  23964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23964
uuuuggcuuu ccuuaguaag                                                   20


<210>  23965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23965
uuaguaaguu uagcagccau                                                   20


<210>  23966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23966
aaaguccuga caaugccaac                                                   20


<210>  23967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23967
gcggcucaau caugcaauca                                                   20


<210>  23968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23968
auuuacaauu ugucuuagaa                                                   20


<210>  23969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23969
aagacaaauu guaaauagaa                                                   20


<210>  23970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23970
cugacauugu acuuugacaa                                                   20


<210>  23971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23971
caaccuuucu cugucuuauu                                                   20


<210>  23972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23972
cugucuuauu uacaaauaca                                                   20


<210>  23973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23973
ugaacauuag ucuuuggaua                                                   20


<210>  23974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23974
ugaaacuggg aguccuauau                                                   20


<210>  23975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23975
uagggagccu auguuuguga                                                   20


<210>  23976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23976
aauaaguacc uaggauuuuc                                                   20


<210>  23977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23977
cuacucucug gauuuugaag                                                   20


<210>  23978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23978
aaauccagag aguagagaau                                                   20


<210>  23979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23979
ccaguauauu guuuuuugug                                                   20


<210>  23980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23980
gcauggcagu uaaaacaaaa                                                   20


<210>  23981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23981
cuucagaagu cagucguuuu                                                   20


<210>  23982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23982
gaagucaguc guuuuuauuc                                                   20


<210>  23983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23983
gaagugaauu uucagcaugg                                                   20


<210>  23984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23984
gaaucacaua aauaaagaga                                                   20


<210>  23985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23985
gaauaaaaac gacugacuuc                                                   20


<210>  23986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23986
cuuuauuuau gugauucuga                                                   20


<210>  23987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23987
uuucucuuua uuuaugugau                                                   20


<210>  23988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23988
gucugagcua ggagagaauc                                                   20


<210>  23989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23989
cuccuagcuc agacugaacu                                                   20


<210>  23990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23990
gauucucucc uagcucagac                                                   20


<210>  23991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23991
uuuuguaucc auucugauuc                                                   20


<210>  23992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23992
uuuucuaaau ucugaaaagc                                                   20


<210>  23993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23993
aaauucugaa aagcauauug                                                   20


<210>  23994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23994
gaaaagcaua uuguauuuga                                                   20


<210>  23995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23995
gaauuuagaa aaugaacuua                                                   20


<210>  23996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23996
auuuugaauu acuauaucuc                                                   20


<210>  23997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23997
aaauggaaau acauuagcau                                                   20


<210>  23998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23998
uuagaguauc ugucugauau                                                   20


<210>  23999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  23999
ugauuuuaaa gagaaaaaau                                                   20


<210>  24000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24000
cuuuaaaauc augaacauag                                                   20


<210>  24001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24001
cuagucucuc aaaaagcuaa                                                   20


<210>  24002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24002
uaugugcaau aagccaaaac                                                   20


<210>  24003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24003
auaagggaac agcaguuuca                                                   20


<210>  24004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24004
cuuauagaaa agacccaaac                                                   20


<210>  24005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24005
cauucaguaa ucuuccauga                                                   20


<210>  24006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24006
guaaucuucc augaauauuu                                                   20


<210>  24007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24007
augaauauuu ccccccauca                                                   20


<210>  24008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24008
uggaagauua cugaauguga                                                   20


<210>  24009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24009
ccccaucaua aaauaugaga                                                   20


<210>  24010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24010
uuuuuuuuag ucucauauuu                                                   20


<210>  24011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24011
auagggguuu uguuuuguuu                                                   20


<210>  24012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24012
ucaauaugug ugucaaauau                                                   20


<210>  24013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24013
cagcuaaauu aauacuacuu                                                   20


<210>  24014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24014
augaucucaa uggaucacaa                                                   20


<210>  24015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24015
aaauauugug ugauugugau                                                   20


<210>  24016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24016
uuuuauuuaa auauucaaaa                                                   20


<210>  24017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24017
uccacguaca cauaugagcu                                                   20


<210>  24018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24018
ccagguaaaa agaauccucu                                                   20


<210>  24019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24019
uuuuaccugg ugaauagaug                                                   20


<210>  24020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24020
agaccagccu ggccaacaug                                                   20


<210>  24021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24021
ccauguuggc caggcugguc                                                   20


<210>  24022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24022
guagaggcag gguuucacca                                                   20


<210>  24023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24023
ccugccucag ccucccaagu                                                   20


<210>  24024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24024
agcgauucuc cugccucagc                                                   20


<210>  24025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24025
cuguacucag gccucuccaa                                                   20


<210>  24026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24026
uuaaaucuug aguaaaaugg                                                   20


<210>  24027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24027
ccuaucugaa agucccgaau                                                   20


<210>  24028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24028
gauaggagaa uaaggcagag                                                   20


<210>  24029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24029
ggacuuucag auaggagaau                                                   20


<210>  24030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24030
aagcuuuauu uaucuuagga                                                   20


<210>  24031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24031
uaagauaaau aaagcuuaga                                                   20


<210>  24032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24032
uccuaagaua aauaaagcuu                                                   20


<210>  24033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24033
ugcuuccugc cuauaaaaua                                                   20


<210>  24034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24034
ugccuauaaa auaguacagg                                                   20


<210>  24035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24035
cugugagccu guacuauuuu                                                   20


<210>  24036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24036
uacccagcac gcuuaaauga                                                   20


<210>  24037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24037
ucuagagauu caucaauaua                                                   20


<210>  24038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24038
agagauucau caauauaucu                                                   20


<210>  24039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24039
ucaauauauc ucuuuccuua                                                   20


<210>  24040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24040
uuaauacaag gcauugcuuc                                                   20


<210>  24041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24041
ccuuucuuuu ugugacacaa                                                   20


<210>  24042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24042
uuuugugaca caauucaaau                                                   20


<210>  24043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24043
aauaucuacu gaaugauuac                                                   20


<210>  24044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24044
guagauauuu gaauuguguc                                                   20


<210>  24045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24045
uuccucauca uaaaaagaaa                                                   20


<210>  24046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24046
ucaucauaaa aagaaaagca                                                   20


<210>  24047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24047
uuuuaugaug aggaaggaaa                                                   20


<210>  24048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24048
aagucugcuu uucuuuuuau                                                   20


<210>  24049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24049
cuaaagcacg ucugcacaau                                                   20


<210>  24050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24050
agaacuucgc uucaggggca                                                   20


<210>  24051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24051
ggaagacggc ugugugugua                                                   20


<210>  24052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24052
cuucaggggc accugagggc                                                   20


<210>  24053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24053
ggggcaccug agggccagag                                                   20


<210>  24054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24054
gacgcucugg cccucaggug                                                   20


<210>  24055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24055
accauugcac auaaauuccg                                                   20


<210>  24056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24056
ccauaggaaa cucuuaauuc                                                   20


<210>  24057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24057
uauggugaag uuaacauucu                                                   20


<210>  24058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24058
uuacugugaa uuaugagaag                                                   20


<210>  24059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24059
caguaaugaa uuaagaguuu                                                   20


<210>  24060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24060
cauaauucac aguaaugaau                                                   20


<210>  24061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24061
aguuacugac aucucacuuu                                                   20


<210>  24062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24062
gccaguucca gggugggaac                                                   20


<210>  24063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24063
agggugggaa caggugauua                                                   20


<210>  24064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24064
cacccuggaa cuggcugaac                                                   20


<210>  24065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24065
uuguguuuaa ucaccuguuc                                                   20


<210>  24066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24066
uucauugugu uuaaucaccu                                                   20


<210>  24067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24067
ugcacgaaag guuuaccuca                                                   20


<210>  24068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24068
ugcaugaaua auuacaaagu                                                   20


<210>  24069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24069
augggcgcac aacaagugcu                                                   20


<210>  24070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24070
ucucaguuaa augauugauu                                                   20


<210>  24071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24071
cuaggcucug cuauuauacu                                                   20


<210>  24072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24072
uuaaaaaaau aauaacagaa                                                   20


<210>  24073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24073
guuauuauuu uuuuaaagaa                                                   20


<210>  24074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24074
agcaaauauc ucuuauuucc                                                   20


<210>  24075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24075
cuacauagau ucacaacuau                                                   20


<210>  24076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24076
caacuauagc aguaaaaguc                                                   20


<210>  24077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24077
ccccagcauu uagauuccuc                                                   20


<210>  24078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24078
uccucuaaau acagaggcac                                                   20


<210>  24079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24079
gugccucugu auuuagagga                                                   20


<210>  24080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24080
gucuuagauu aaccagcuca                                                   20


<210>  24081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24081
uacugagguc ccaaauaggu                                                   20


<210>  24082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24082
ugcuugacag acacuguguu                                                   20


<210>  24083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24083
gagauccaaa gccuugcuaa                                                   20


<210>  24084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24084
gccugcucuu gcuucauuaa                                                   20


<210>  24085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24085
uuaaucaugc cuuacacuuc                                                   20


<210>  24086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24086
guucauuuuc cuuccaguca                                                   20


<210>  24087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24087
uuuuccuucc agucacaaga                                                   20


<210>  24088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24088
uuccagucac aagacaacac                                                   20


<210>  24089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24089
agucacaaga caacacaugg                                                   20


<210>  24090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24090
auguguuguc uugugacugg                                                   20


<210>  24091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24091
cacauccugc ugggggguag                                                   20


<210>  24092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24092
ccuacauguc acauaaggua                                                   20


<210>  24093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24093
agaaauacac uccacaaaug                                                   20


<210>  24094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24094
ugaauccacc acauuuaccu                                                   20


<210>  24095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24095
cuagcagcag auuucccauu                                                   20


<210>  24096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24096
cauuucacua aagggaaagu                                                   20


<210>  24097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24097
cuaaagggaa aguaucugag                                                   20


<210>  24098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24098
cuuuagugaa augggaaauc                                                   20


<210>  24099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24099
gugauagcac ucagauacuu                                                   20


<210>  24100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24100
uuuuuuagug cuuucuguga                                                   20


<210>  24101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24101
uucuuuuuuu agugcuuucu                                                   20


<210>  24102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24102
agagggggag aggagaaaua                                                   20


<210>  24103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24103
ccucuccccc ucuagaauuu                                                   20


<210>  24104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24104
acuuuguggu caaacuaggu                                                   20


<210>  24105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24105
agugaaucaa uucaugauau                                                   20


<210>  24106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24106
cuggaacuug ucucuccgac                                                   20


<210>  24107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24107
ugauaugcac uaccuuuccu                                                   20


<210>  24108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24108
uaaaacugaa caaaccucuu                                                   20


<210>  24109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24109
guuuuaggaa agguagugca                                                   20


<210>  24110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24110
ggagcugggu gguagguaga                                                   20


<210>  24111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24111
aucuaccuac cacccagcuc                                                   20


<210>  24112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24112
uccaucuacc uaccacccag                                                   20


<210>  24113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24113
gugaugacag acaugccaug                                                   20


<210>  24114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24114
cuaagugaua aacaguaaca                                                   20


<210>  24115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24115
cuucucuaag ugauaaacag                                                   20


<210>  24116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24116
uuuucccuug agcugccgag                                                   20


<210>  24117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24117
cuugagcugc cgagaaaccc                                                   20


<210>  24118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24118
cggcagcuca agggaaaagg                                                   20


<210>  24119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24119
acagcccucc cuccuuuggu                                                   20


<210>  24120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24120
aagaaaauuu uuacauugug                                                   20


<210>  24121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24121
uggaaaaaua cacacacgua                                                   20


<210>  24122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24122
gcuauaacac aauguaaaaa                                                   20


<210>  24123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24123
cugugcucuc ucuugucucu                                                   20


<210>  24124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24124
ugucaaacca accuuuugaa                                                   20


<210>  24125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24125
aaagguuggu uugacaggaa                                                   20


<210>  24126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24126
aacaugcccu uaaacuuuuc                                                   20


<210>  24127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24127
aguaagcaug ucugugcgcu                                                   20


<210>  24128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24128
gcaacugccc ucucuacucu                                                   20


<210>  24129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24129
acuggccagg ccagaguaga                                                   20


<210>  24130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24130
gggcuagccu uggauccaua                                                   20


<210>  24131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24131
accaccucca acuacccugc                                                   20


<210>  24132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24132
gggaagccuu gagaacgagc                                                   20


<210>  24133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24133
cugaaguaga gugggcuggc                                                   20


<210>  24134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24134
caaggcuucc cugaaguaga                                                   20


<210>  24135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24135
gcucguucuc aaggcuuccc                                                   20


<210>  24136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24136
gagucaaaca agucauuggc                                                   20


<210>  24137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24137
gccaaugacu uguuugacuc                                                   20


<210>  24138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24138
agccuuggug acgugucaga                                                   20


<210>  24139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24139
auuguccauu uccagccuug                                                   20


<210>  24140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24140
aaaugagaag guggggaugg                                                   20


<210>  24141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24141
cauuuugaag uauugagcuu                                                   20


<210>  24142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24142
ccauccccac cuucucauuu                                                   20


<210>  24143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24143
uccccauccc caccuucuca                                                   20


<210>  24144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24144
uuucuucccc auccccaccu                                                   20


<210>  24145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24145
cucuggaucu gucgauuuug                                                   20


<210>  24146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24146
gugaggugga aaauauuuau                                                   20


<210>  24147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24147
accucacuga aucagaugua                                                   20


<210>  24148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24148
guguucugga cguaagcaac                                                   20


<210>  24149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24149
ggacguaagc aacagaaaug                                                   20


<210>  24150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24150
guugcuuacg uccagaacac                                                   20


<210>  24151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24151
cuauuacucu augugacugu                                                   20


<210>  24152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24152
caacuccuua cugcuuggcu                                                   20


<210>  24153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24153
gaggugcugu agccaagcag                                                   20


<210>  24154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24154
uuuucagagg ugcuguagcc                                                   20


<210>  24155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24155
uuucauuuuc agaggugcug                                                   20


<210>  24156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24156
ccuugcuucu cauuuaccug                                                   20


<210>  24157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24157
cauuuaccug cuauguguuc                                                   20


<210>  24158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24158
uguuuggggc aaauuccucu                                                   20


<210>  24159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24159
ucuagaugac guugauaaac                                                   20


<210>  24160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24160
ucucgauugg ugaaggggaa                                                   20


<210>  24161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24161
ccaaucgaga ugaaaaaagc                                                   20


<210>  24162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24162
ccuucaccaa ucgagaugaa                                                   20


<210>  24163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24163
aagcagaggc ugccauugca                                                   20


<210>  24164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24164
guuugugcuc gauaaaaaua                                                   20


<210>  24165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24165
uauuuuuauc gagcacaaac                                                   20


<210>  24166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24166
cauuggggga cauucuuauu                                                   20


<210>  24167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24167
ucuggcacug cccacaggug                                                   20


<210>  24168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24168
ggagcuccca acgggccgug                                                   20


<210>  24169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24169
ucaucuguaa gaauggcuuc                                                   20


<210>  24170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24170
uacagaugau gaaccagacc                                                   20


<210>  24171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24171
agaggcucgg cugugguugg                                                   20


<210>  24172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24172
ccaaccacag ccgagccucu                                                   20


<210>  24173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24173
guccucucug gcacucuaau                                                   20


<210>  24174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24174
ccccuuucug uccucucugg                                                   20


<210>  24175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24175
aggcuucucu auauaauacc                                                   20


<210>  24176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24176
cuauauaaua cccagaaaau                                                   20


<210>  24177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24177
ggguauuaua uagagaagcc                                                   20


<210>  24178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24178
cauccuugua cuuuuuguau                                                   20


<210>  24179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24179
uuacauaugu gaugauuugc                                                   20


<210>  24180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24180
uugcauaacu ccagagaaca                                                   20


<210>  24181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24181
cuggaguuau gcaaggaaga                                                   20


<210>  24182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24182
aaacuuacaa accagacaca                                                   20


<210>  24183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24183
uucuaaacuu acaaaccaga                                                   20


<210>  24184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24184
cuguguuaac uauuuaagua                                                   20


<210>  24185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24185
uuauguuccc uguguuaacu                                                   20


<210>  24186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24186
uguaguuauu auuuaagcuu                                                   20


<210>  24187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24187
auccacuuuu uuuuuuaacc                                                   20


<210>  24188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24188
uuuuuccuau acaccaaguu                                                   20


<210>  24189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24189
uauacaccaa guuguccauu                                                   20


<210>  24190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24190
uuggcacaau ggacaacuug                                                   20


<210>  24191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24191
uucuuuggca caauggacaa                                                   20


<210>  24192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24192
ccucuccuuu cauucuuugg                                                   20


<210>  24193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24193
cacacaaagg gugugugugu                                                   20


<210>  24194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24194
uaaauuagaa agcuacuaug                                                   20


<210>  24195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24195
aauuuaugaa gccaugucug                                                   20


<210>  24196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24196
ugugacauag uagcuuucua                                                   20


<210>  24197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24197
uauuacagca guguaaaugu                                                   20


<210>  24198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24198
uaggugcaug cagucguuuu                                                   20


<210>  24199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24199
cacugccaaa aaccuuucug                                                   20


<210>  24200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24200
gcucucacuc ucagcagugc                                                   20


<210>  24201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24201
uugauuuugu ggcacugcug                                                   20


<210>  24202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24202
cagacacauu agcuaaaugg                                                   20


<210>  24203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24203
uaaguacuca aaaguauccc                                                   20


<210>  24204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24204
gagaaaugga augccuauaa                                                   20


<210>  24205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24205
cagaauaaaa aaaaaaugac                                                   20


<210>  24206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24206
auuucucaga auaaaaaaaa                                                   20


<210>  24207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24207
aaacauguuu gcacuuggug                                                   20


<210>  24208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24208
gauuuuuaua ucauagaugc                                                   20


<210>  24209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24209
gagcaaggcu gagaaguccu                                                   20


<210>  24210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24210
cagccuugcu cugaaaugug                                                   20


<210>  24211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24211
uuagacuuga aauacuucgc                                                   20


<210>  24212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24212
agucuaaaga aaggacuucu                                                   20


<210>  24213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24213
ccuaauguug ucaaagugga                                                   20


<210>  24214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24214
gaaugagcuc caaaaugcuu                                                   20


<210>  24215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24215
gaaaauuagu ccacuuugac                                                   20


<210>  24216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24216
uuaugagacu auuucugcac                                                   20


<210>  24217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24217
gcacacauaa ucaccagcgg                                                   20


<210>  24218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24218
uuccuguuug cuuuuuuuuu                                                   20


<210>  24219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24219
uguuugcuuu uuuuuuuaac                                                   20


<210>  24220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24220
aucauuuuuu aagcuuccaa                                                   20


<210>  24221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24221
aaaggggaaa agagaguugg                                                   20


<210>  24222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24222
ccuuuggaag cuuaaaaaau                                                   20


<210>  24223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24223
caagcagaga cuuaccaacu                                                   20


<210>  24224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24224
guuuuauuaa cuggcagcau                                                   20


<210>  24225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24225
gcuucaguuu uauuaacugg                                                   20


<210>  24226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24226
uuagcaagcu gccaauuuua                                                   20


<210>  24227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24227
uuaaauguaa aauuggcagc                                                   20


<210>  24228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24228
cuguggcuuu aaguucauua                                                   20


<210>  24229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24229
acacucaaau uaaaaucuau                                                   20


<210>  24230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24230
aauauucuac acucaaauua                                                   20


<210>  24231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24231
cuggauuuuu gcacuuuauc                                                   20


<210>  24232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24232
acccuaccca ggcugaauau                                                   20


<210>  24233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24233
gccuggguag gguugaaaua                                                   20


<210>  24234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24234
cccucaauau ucagccuggg                                                   20


<210>  24235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24235
ccuagcacau cugggaguua                                                   20


<210>  24236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24236
agccucuggu acuccuccua                                                   20


<210>  24237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24237
uguggugacc uuauguuaaa                                                   20


<210>  24238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24238
uauuccugug gugaccuuau                                                   20


<210>  24239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24239
uacuaauaaa gacaguaaag                                                   20


<210>  24240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24240
uugcccaaca uacuggccaa                                                   20


<210>  24241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24241
guauuuaucu uuuggccagu                                                   20


<210>  24242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24242
aauaaaagaa gacaaacaga                                                   20


<210>  24243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24243
uuuauuugaa aaguaugcau                                                   20


<210>  24244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24244
guuugucuuc uuuuauuuga                                                   20


<210>  24245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24245
ucucuuacau uugcuuccau                                                   20


<210>  24246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24246
cuuacauuug cuuccauuuu                                                   20


<210>  24247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24247
auuuugacca agugaggaau                                                   20


<210>  24248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24248
ucacuugguc aaaauggaag                                                   20


<210>  24249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24249
cuauuccuca cuuggucaaa                                                   20


<210>  24250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24250
caaaauauuc cuguugucug                                                   20


<210>  24251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24251
uguugucuga auuaaggauu                                                   20


<210>  24252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24252
gacaacagga auauuuugag                                                   20


<210>  24253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24253
gagguuuaca gacugaagga                                                   20


<210>  24254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24254
gucuguaaac cucagaacuu                                                   20


<210>  24255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24255
uucagucugu aaaccucaga                                                   20


<210>  24256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24256
uaagucuucc uucagucugu                                                   20


<210>  24257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24257
auguacuagu aaguuugaua                                                   20


<210>  24258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24258
accguuaaga uucuuuuuuu                                                   20


<210>  24259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24259
uuuuuuuuuu uuuuuguucc                                                   20


<210>  24260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24260
caaggucuga cacauuucua                                                   20


<210>  24261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24261
aaaaguggga auauuauuua                                                   20


<210>  24262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24262
cacuuuuaga aaugugucag                                                   20


<210>  24263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24263
uuuugcaccu aaauaauauu                                                   20


<210>  24264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24264
ccuagguauc aaauaguuaa                                                   20


<210>  24265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24265
aaacagacuu gguuaaaguc                                                   20


<210>  24266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24266
aaauguagug acugaacuga                                                   20


<210>  24267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24267
gucacuacau uuagaagacu                                                   20


<210>  24268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24268
cgguuuugau uguaaaucag                                                   20


<210>  24269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24269
uuucccgguu uugauuguaa                                                   20


<210>  24270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24270
gagguugcug auuacaccuc                                                   20


<210>  24271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24271
ccuaauuaau uuuauaggag                                                   20


<210>  24272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24272
ugaaaauaac aagaugauca                                                   20


<210>  24273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24273
agaacuuugc cuccuauaaa                                                   20


<210>  24274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24274
augcucuuaa cguaaauuau                                                   20


<210>  24275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24275
uguuaauuag caauaauuua                                                   20


<210>  24276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24276
aauguaugaa auacguuuaa                                                   20


<210>  24277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24277
uacauuagaa uauaauucuu                                                   20


<210>  24278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24278
gagaaauacc aaaacguguu                                                   20


<210>  24279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24279
cugaacacca cuagccaaau                                                   20


<210>  24280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24280
uuguguccca cuuugucuga                                                   20


<210>  24281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24281
uauuuucuuu gugucccacu                                                   20


<210>  24282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24282
caugguguag ucuacugauu                                                   20


<210>  24283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24283
caguggcaau caacauuucc                                                   20


<210>  24284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24284
uuucugggca ucugauaauu                                                   20


<210>  24285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24285
gggcaucuga uaauuucucu                                                   20


<210>  24286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24286
cugcauuuua augcaaauuc                                                   20


<210>  24287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24287
ccuuucccua aaaaccuucc                                                   20


<210>  24288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24288
cuaaaaaccu uccuaacccu                                                   20


<210>  24289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24289
uaacccucag ccauuuaccc                                                   20


<210>  24290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24290
acuccauccu ccuucgcccc                                                   20


<210>  24291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24291
ccccaacaau accaacauuu                                                   20


<210>  24292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24292
aagcuccggc cuaaacuccg                                                   20


<210>  24293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24293
aucgaggacu cccugcuuug                                                   20


<210>  24294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24294
acuucaaucg aggacucccu                                                   20


<210>  24295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24295
cggcuaauua uuaugauuau                                                   20


<210>  24296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24296
cucuacgagg ggaggaagaa                                                   20


<210>  24297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24297
uccccucgua gagagaauuc                                                   20


<210>  24298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24298
uccuccccuc guagagagaa                                                   20


<210>  24299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24299
auuucuuccu ccccucguag                                                   20


<210>  24300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24300
acguucaaac agcaagacag                                                   20


<210>  24301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24301
aacagcaaga cagccuggaa                                                   20


<210>  24302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24302
aggcugucuu gcuguuugaa                                                   20


<210>  24303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24303
ucucugugua guugcaaaag                                                   20


<210>  24304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24304
uuugcaacua cacagagagg                                                   20


<210>  24305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24305
cuuaaauuua uucuuuugca                                                   20


<210>  24306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24306
uauaaggauu auuuuuuucc                                                   20


<210>  24307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24307
cccucccccu ccgcuccccg                                                   20


<210>  24308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24308
aguuugcuuu ccaaguccuu                                                   20


<210>  24309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24309
aaguccuucu ccuugauugu                                                   20


<210>  24310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24310
ccuugauugu cuuaacaggg                                                   20


<210>  24311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24311
uuacccuguu aagacaauca                                                   20


<210>  24312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24312
gccuccguuu gcuucuuuac                                                   20


<210>  24313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24313
gagaggaaaa gcaaagaaac                                                   20


<210>  24314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24314
ucucugaauu ucagccuccg                                                   20


<210>  24315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24315
uugcuuuucc ucucugaauu                                                   20


<210>  24316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24316
gcacggucca cccuugccgg                                                   20


<210>  24317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24317
cuuucugcac gguccacccu                                                   20


<210>  24318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24318
cagcaagcgc ggcgggagcc                                                   20


<210>  24319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24319
cugggccugc caguugguga                                                   20


<210>  24320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24320
ccaacuggca ggcccaggga                                                   20


<210>  24321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24321
uuuuucacca acuggcaggc                                                   20


<210>  24322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24322
aaaccucacu uccuuuuuca                                                   20


<210>  24323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24323
uucugugucc acaagcuuac                                                   20


<210>  24324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24324
guguccacaa gcuuacacuu                                                   20


<210>  24325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24325
cccgcaauuc ugggcacugg                                                   20


<210>  24326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24326
gggcacuggg ugugcgcggc                                                   20


<210>  24327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24327
uuauuaauga cgcugccugc                                                   20


<210>  24328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24328
gagcuccgag gcgagagggg                                                   20


<210>  24329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24329
acccccucac ccccaugcaa                                                   20


<210>  24330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24330
uccacccccu cacccccaug                                                   20


<210>  24331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24331
gccaugcccc gaagcccuag                                                   20


<210>  24332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24332
gggcauggcc gaagaggggg                                                   20


<210>  24333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24333
ucccuaccaa aaaugccggc                                                   20


<210>  24334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24334
gggccggcau uuuugguagg                                                   20


<210>  24335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24335
uucggggccg gcauuuuugg                                                   20


<210>  24336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24336
cuuucuuucg gggccggcau                                                   20


<210>  24337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24337
ccgcggcccc ggccagaagc                                                   20


<210>  24338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24338
ggccggggcc gcggagaagc                                                   20


<210>  24339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24339
uuuugacuuu aaaaaugcuu                                                   20


<210>  24340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24340
ucauuuugac uuuaaaaaug                                                   20


<210>  24341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24341
cucccccauc accccguaug                                                   20


<210>  24342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24342
cuuucucucc cccaucaccc                                                   20


<210>  24343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24343
gccuaaccgu ucuuuccccc                                                   20


<210>  24344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24344
uuccccccac ccccacccuc                                                   20


<210>  24345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24345
ccccaccccc acccucgcaa                                                   20


<210>  24346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24346
uccccggacg agaaucgccg                                                   20


<210>  24347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24347
cguccgggga ggaacgagcu                                                   20


<210>  24348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24348
aguucgcuga gcuuucuuga                                                   20


<210>  24349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24349
cugagcuuuc uugaucuugu                                                   20


<210>  24350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24350
ugaucuuguu cugccuccua                                                   20


<210>  24351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24351
gccuccuagc gaccgaaugg                                                   20


<210>  24352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24352
gucgcuagga ggcagaacaa                                                   20


<210>  24353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24353
gcccacauag cagaggcggg                                                   20


<210>  24354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24354
gggugcucag agggggcagg                                                   20


<210>  24355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24355
guccucauuu ucugggugcu                                                   20


<210>  24356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24356
uucuguccuc auuuucuggg                                                   20


<210>  24357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24357
gaagaagggc cugacuuucc                                                   20


<210>  24358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24358
gaaggaugca gugggggcuc                                                   20


<210>  24359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24359
ucggaaggau gcaguggggg                                                   20


<210>  24360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24360
cgaguccugc gaacacugcc                                                   20


<210>  24361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24361
caggacucgg gaaagucagg                                                   20


<210>  24362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24362
uucccgccgg uaccuggccg                                                   20


<210>  24363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24363
cgccgguacc uggccgggcu                                                   20


<210>  24364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24364
caccgccgcg cgccgcgucu                                                   20


<210>  24365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24365
gaagugugug acaaguucca                                                   20


<210>  24366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24366
gaagcucccc caccccggca                                                   20


<210>  24367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24367
agggcccagu gaaaaauuaa                                                   20


<210>  24368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24368
cugggcccug gaacuuguca                                                   20


<210>  24369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24369
cugugcgcac cccccaccac                                                   20


<210>  24370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24370
guguuuuuuu aaaggggugg                                                   20


<210>  24371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24371
uacuuuaaau uuuugaugca                                                   20


<210>  24372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24372
cccccuacuc aauuuaugau                                                   20


<210>  24373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24373
uucccuugcu gccaaacuuu                                                   20


<210>  24374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24374
cuugcugcca aacuuuccua                                                   20


<210>  24375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24375
uaagugccca ccgcccgccu                                                   20


<210>  24376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24376
aggcgcaguc agcgggagac                                                   20


<210>  24377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24377
ugugagucug uauaagagcu                                                   20


<210>  24378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24378
ccaggccugg cuuggucuga                                                   20


<210>  24379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24379
cccuuugggu cuugcccucu                                                   20


<210>  24380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24380
ccccugcccu uccccggcaa                                                   20


<210>  24381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24381
ccggcaaccc cgccaccugg                                                   20


<210>  24382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24382
cugcccaccc cccaccccgc                                                   20


<210>  24383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24383
cagacgucuc uuguccacag                                                   20


<210>  24384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24384
gcgccucccc uccccuccgc                                                   20


<210>  24385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24385
cccagccgau uucgcagucu                                                   20


<210>  24386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24386
cagucuggga ggucgagaag                                                   20


<210>  24387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24387
cgaccuccca gacugcgaaa                                                   20


<210>  24388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24388
gacacgagau uuuucccaau                                                   20


<210>  24389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24389
caaucaaaau ccacuuccac                                                   20


<210>  24390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24390
acuuuuuuug aaaaucuucc                                                   20


<210>  24391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24391
aaaaaagugg aaguggauuu                                                   20


<210>  24392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24392
aaaaaauagu aagaggaggg                                                   20


<210>  24393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24393
ucucucccuc uccgugccgu                                                   20


<210>  24394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24394
guugcaaacu uagggcgccg                                                   20


<210>  24395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24395
cccaaacccc uucaguugca                                                   20


<210>  24396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24396
agaugagaga uugugagauu                                                   20


<210>  24397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24397
cuuugacucc cccaccagcc                                                   20


<210>  24398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24398
gugacggccu ucucuuugac                                                   20


<210>  24399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24399
guuugggggc aagaaauugu                                                   20


<210>  24400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24400
ugcccccaaa ccgaagccaa                                                   20


<210>  24401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24401
cuugccuugu uuuauuuauu                                                   20


<210>  24402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24402
ccuugcugcc ucugagguuc                                                   20


<210>  24403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24403
gucgggaggg gagggcagcg                                                   20


<210>  24404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24404
gcggcggcgg cggcggcggc                                                   20


<210>  24405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24405
ggccagaggu ggguguuugu                                                   20


<210>  24406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24406
cggucccacg gcucuccccg                                                   20


<210>  24407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24407
acagugccac uuucucacua                                                   20


<210>  24408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24408
cacuauugug gggaugacua                                                   20


<210>  24409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24409
ucccgcugca cacuugaccg                                                   20


<210>  24410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24410
ccccgggaau cguuuuuuag                                                   20


<210>  24411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24411
cggggagaaa agaggugaga                                                   20


<210>  24412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24412
uacggugagu gggaagcaac                                                   20


<210>  24413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24413
cacucaccgu aagaaaaugg                                                   20


<210>  24414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24414
ccaccagcuc ccacccccag                                                   20


<210>  24415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24415
caaccuuagc auuguucauu                                                   20


<210>  24416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24416
uuauuuugca aaacuggcgg                                                   20


<210>  24417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24417
acuccccccc cgccccgcca                                                   20


<210>  24418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24418
uuuucgaaaa gagaaauaaa                                                   20


<210>  24419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24419
aaaagagaaa uaaagcggcg                                                   20


<210>  24420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24420
aaaaggaaug caaugauucc                                                   20


<210>  24421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24421
cuuuucgaaa aggaaugcaa                                                   20


<210>  24422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24422
gccgcuuuau uucucuuuuc                                                   20


<210>  24423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24423
uccuuuccgc cgcuuuauuu                                                   20


<210>  24424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24424
agaugggaug aggguuuuuu                                                   20


<210>  24425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24425
cccuuuaucu cuuuuaccuc                                                   20


<210>  24426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24426
cgugaaaaau uuaaaaaugc                                                   20


<210>  24427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24427
cgagaaaaac cuccgagagu                                                   20


<210>  24428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24428
aguccugcgc gcucucguga                                                   20


<210>  24429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24429
cgcguaagua acccaauaau                                                   20


<210>  24430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24430
cguuugcuua agugcugggg                                                   20


<210>  24431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24431
caucgggaga gccggguuag                                                   20


<210>  24432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24432
aacccggcuc ucccgaugug                                                   20


<210>  24433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24433
uucuaacccg gcucucccga                                                   20


<210>  24434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24434
cuggagucuc cuucuuucua                                                   20


<210>  24435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24435
ucagugccuu uugacaucca                                                   20


<210>  24436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24436
aauuuauuuu ggaugucaaa                                                   20


<210>  24437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24437
cugcgccauc uuuguauuau                                                   20


<210>  24438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24438
ucuucccugc gccaucuuug                                                   20


<210>  24439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24439
cucucucucc cucuuuuuuu                                                   20


<210>  24440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24440
ucucucucuc ucucucuccc                                                   20


<210>  24441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24441
agugcggacg ugacgucccu                                                   20


<210>  24442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24442
cagggacguc acguccgcac                                                   20


<210>  24443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24443
aguucgcagg gacgucacgu                                                   20


<210>  24444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24444
cuccugcucg cccugcccau                                                   20


<210>  24445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24445
cuccuccccu ucucuccugc                                                   20


<210>  24446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24446
ccuucccucc uccccuucuc                                                   20


<210>  24447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24447
uguccagccc cugaugugug                                                   20


<210>  24448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24448
cucccggcca cgccaccgcc                                                   20


<210>  24449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24449
ucucucccgg ccacgccacc                                                   20


<210>  24450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24450
ucccaccccu gccaccccuu                                                   20


<210>  24451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24451
uuuuagaguc cgcgugugug                                                   20


<210>  24452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24452
aaaaagaaaa aaauagagcg                                                   20


<210>  24453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24453
uuuuugaaua aucuuucauu                                                   20


<210>  24454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24454
ccagcccggg gcugcagccu                                                   20


<210>  24455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24455
cuccgcccgc gcuuccccag                                                   20


<210>  24456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24456
ccuccccgcc gccgccgcgc                                                   20


<210>  24457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24457
gccccuggcg uccacacgcg                                                   20


<210>  24458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24458
cgagcgcagc cgcgggcucg                                                   20


<210>  24459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24459
uugcuguccu cuccucgggc                                                   20


<210>  24460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24460
ggugauuuuu cuuugcuguc                                                   20


<210>  24461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24461
gcguugccgu gcgcucccuc                                                   20


<210>  24462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24462
ggacccgcag cccuccaaac                                                   20


<210>  24463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24463
aggccgcgcg ggcuccugga                                                   20


<210>  24464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24464
cggucccugg cucggccuug                                                   20


<210>  24465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24465
gacccagucg cuuggcgggg                                                   20


<210>  24466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24466
guugcauuca gacccagucg                                                   20


<210>  24467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24467
gcgacccuua ggagccgggg                                                   20


<210>  24468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24468
ucgggcucuc uuucugcgac                                                   20


<210>  24469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24469
uuauuccucg ggcucucuuu                                                   20


<210>  24470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24470
cagggacugg gacucccggg                                                   20


<210>  24471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24471
caucccucug ugcuuuugca                                                   20


<210>  24472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24472
ucccaucccu cugugcuuuu                                                   20


<210>  24473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24473
uacgggcaga gcacaacugu                                                   20


<210>  24474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24474
ugugcuguua cccagggaaa                                                   20


<210>  24475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24475
cuggguaaca gcacaggaac                                                   20


<210>  24476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24476
cuuucccugg guaacagcac                                                   20


<210>  24477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24477
cauuuucucu uucccugggu                                                   20


<210>  24478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24478
gcagacguuc ccuggaaauu                                                   20


<210>  24479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24479
cuggaaauua gggaagaccu                                                   20


<210>  24480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24480
agggaacguc ugcagaaagg                                                   20


<210>  24481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24481
cuaauuucca gggaacgucu                                                   20


<210>  24482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24482
aacaggucuu cccuaauuuc                                                   20


<210>  24483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24483
cucuggcgug ggauacuuuc                                                   20


<210>  24484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24484
guuuuacgua aaauguacag                                                   20


<210>  24485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24485
aaucgcaggg ggugcuguug                                                   20


<210>  24486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24486
gaaacgugcc uguaaagucc                                                   20


<210>  24487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24487
gaauaaacuu uccaaucgca                                                   20


<210>  24488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24488
aaaucuggaa ggaguugggg                                                   20


<210>  24489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24489
agauuuggaa ucggacugcg                                                   20


<210>  24490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24490
ccucuccccc caacuccuuc                                                   20


<210>  24491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24491
cucuccucgg agcgguucca                                                   20


<210>  24492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24492
acaacccccg ucuucucauc                                                   20


<210>  24493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24493
caucccccuc uucagucuaa                                                   20


<210>  24494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24494
gucuaaaggg ugucgcuucc                                                   20


<210>  24495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24495
guaaacucac ccacccggug                                                   20


<210>  24496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24496
uguuucgucu uaguaaaguu                                                   20


<210>  24497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24497
ucuuaguaaa guuucaaguc                                                   20


<210>  24498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24498
agucuacugu guuagaaaau                                                   20


<210>  24499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24499
aacacaguag acuugaaacu                                                   20


<210>  24500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24500
gaccccucua aggaagaaaa                                                   20


<210>  24501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24501
uuagaggggu ccgaagcucc                                                   20


<210>  24502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24502
uccuuagagg gguccgaagc                                                   20


<210>  24503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24503
cuccaguuug ugggagggag                                                   20


<210>  24504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24504
guuuaagaag cgggaggauu                                                   20


<210>  24505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24505
uaaacagaau uugaggucuc                                                   20


<210>  24506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24506
cuagaaguua agcucuguag                                                   20


<210>  24507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24507
agugaauccu cccgcuucuu                                                   20


<210>  24508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24508
ccuuuucacu gaguucuuca                                                   20


<210>  24509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24509
cugaguucuu cagagcaggu                                                   20


<210>  24510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24510
ucagagcagg ucagcaucuc                                                   20


<210>  24511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24511
gagcagguca gcaucucuau                                                   20


<210>  24512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24512
accacagucu gcuuuuuguc                                                   20


<210>  24513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24513
uuuggugacu ccaaggcugg                                                   20


<210>  24514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24514
uggggggugg cgggggagga                                                   20


<210>  24515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24515
cuccaaccgu cccccacguc                                                   20


<210>  24516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24516
ccuucccucc aaccgucccc                                                   20


<210>  24517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24517
cucucuucac cuucccucca                                                   20


<210>  24518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24518
ucccucucuu caccuucccu                                                   20


<210>  24519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24519
ucuucccucu cuucaccuuc                                                   20


<210>  24520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24520
aaggccuccc aguugcacuu                                                   20


<210>  24521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24521
uuuauuuauu uauuuuucaa                                                   20


<210>  24522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24522
gguaacaaua gugagccaga                                                   20


<210>  24523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24523
uucagaacca agcuuuucag                                                   20


<210>  24524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24524
gaaccaagcu uuucagauuu                                                   20


<210>  24525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24525
gaaagaaucu ggcucacuau                                                   20


<210>  24526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24526
gauuugaaua uuguucccac                                                   20


<210>  24527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24527
aaucugaaaa gcuugguucu                                                   20


<210>  24528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24528
cacccgucca uaaaagucca                                                   20


<210>  24529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24529
cuauagaugg acuuuuaugg                                                   20


<210>  24530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24530
acaacacuca cucgcucauu                                                   20


<210>  24531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24531
ggguuggcug uaguguaaaa                                                   20


<210>  24532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24532
gagguaauaa agucauuacu                                                   20


<210>  24533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24533
gugguucaca uuuaacaguc                                                   20


<210>  24534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24534
cauuuaacag ucuucugaau                                                   20


<210>  24535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24535
gaauuacaau ucauuacaca                                                   20


<210>  24536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24536
gaagacuguu aaaugugaac                                                   20


<210>  24537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24537
uuacacaauu gugugcgcuc                                                   20


<210>  24538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24538
aauaaauaac uggcaacauu                                                   20


<210>  24539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24539
uuuuuaaaaa aaaacauagg                                                   20


<210>  24540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24540
uauguuuuuu uuuaaaaagg                                                   20


<210>  24541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24541
gauuccaggg gguuccuucc                                                   20


<210>  24542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24542
aggggguucc uuccuaaacc                                                   20


<210>  24543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24543
uuccuaaacc acaucuuaaa                                                   20


<210>  24544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24544
uaaaccacau cuuaaaacau                                                   20


<210>  24545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24545
cugggugcca aaggagaggu                                                   20


<210>  24546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24546
ccgacauaua uuuaauuuca                                                   20


<210>  24547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24547
ccaucauaau augcccaggg                                                   20


<210>  24548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24548
cccugggcau auuaugaugg                                                   20


<210>  24549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24549
cauuucaccc ugggcauauu                                                   20


<210>  24550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24550
cccaguccag aaaaccacgg                                                   20


<210>  24551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24551
ggacugggug aaaucuggcu                                                   20


<210>  24552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24552
ggcucuuuag cgagcaucca                                                   20


<210>  24553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24553
uuaaacacac auacaaaccc                                                   20


<210>  24554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24554
cccccucuac aaaaccaccu                                                   20


<210>  24555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24555
agaaguggcu uuuagaaagu                                                   20


<210>  24556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24556
ggaaagguaa auauacuuau                                                   20


<210>  24557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24557
aaaagccacu ucuggaaagg                                                   20


<210>  24558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24558
ggccguucag uuaacuucgu                                                   20


<210>  24559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24559
guuaacuucg uuuggggcug                                                   20


<210>  24560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24560
uuuggggcug uagagcuguu                                                   20


<210>  24561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24561
augggagcag caacagcucu                                                   20


<210>  24562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24562
gugggcucuu ucccaaaccu                                                   20


<210>  24563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24563
caaaccuuug gugacgacac                                                   20


<210>  24564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24564
cuccuccccc uuuuuaucuu                                                   20


<210>  24565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24565
ugcaguauau auucugccuc                                                   20


<210>  24566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24566
gccucugauc uccguacuua                                                   20


<210>  24567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24567
aacagacuuu cugaaauaau                                                   20


<210>  24568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24568
gaaauaaugc acauauauuc                                                   20


<210>  24569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24569
gaaagucugu uagaaaacuu                                                   20


<210>  24570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24570
cgucgguuag aaacccaccg                                                   20


<210>  24571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24571
aaccgacgug aauauaugug                                                   20


<210>  24572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24572
uaguccuuuc aguaguuuuc                                                   20


<210>  24573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24573
guaguuuucg guaugaagua                                                   20


<210>  24574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24574
guaugaagua ugagccgcgu                                                   20


<210>  24575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24575
uaccgaaaac uacugaaagg                                                   20


<210>  24576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24576
aaaagguuac gucuggaggc                                                   20


<210>  24577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24577
gagcccuuga gcuaaaagca                                                   20


<210>  24578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24578
cguucagagc ccuugagcua                                                   20


<210>  24579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24579
agcuguuugu ugaccacauu                                                   20


<210>  24580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24580
ucgcgccagg cgauccucgg                                                   20


<210>  24581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24581
agcucagccc gaguuccucg                                                   20


<210>  24582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24582
ucuuccagcu cagcccgagu                                                   20


<210>  24583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24583
auccugacag accuuuuaac                                                   20


<210>  24584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24584
cugucugccu uuagggggaa                                                   20


<210>  24585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24585
cccuaaaggc agacagugaa                                                   20


<210>  24586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24586
uagacucaaa gauaaauaag                                                   20


<210>  24587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24587
cuuauuuauc uuugagucua                                                   20


<210>  24588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24588
gucauucacu uauuuaucuu                                                   20


<210>  24589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24589
uucagucauu cacuuauuua                                                   20


<210>  24590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24590
uucuugauuu uuacuuuagc                                                   20


<210>  24591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24591
ugauuuuuac uuuagccuuu                                                   20


<210>  24592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24592
ucuuuuuauu ucuuuucuuu                                                   20


<210>  24593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24593
uuuuauuucu uuucuuuuaa                                                   20


<210>  24594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24594
uuucuuuuaa uuuuuauuuu                                                   20


<210>  24595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24595
uuuaauuuuu auuuuuuguu                                                   20


<210>  24596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24596
uaauuggcag gucacaaaau                                                   20


<210>  24597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24597
cuauuuugug accugccaau                                                   20


<210>  24598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24598
uaaaaauaaa acuuagguuu                                                   20


<210>  24599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24599
augcuuggca uagguuuugu                                                   20


<210>  24600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24600
aucauugaga cccaaaauac                                                   20


<210>  24601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24601
uuugucuuaa caacagccua                                                   20


<210>  24602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24602
uuuuuccuuu gucuuaacaa                                                   20


<210>  24603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24603
caacauuuua aaauucauuu                                                   20


<210>  24604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24604
caaagugcug ggauuacagg                                                   20


<210>  24605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24605
agaccagccu ggccaacaau                                                   20


<210>  24606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24606
cauuguuggc caggcugguc                                                   20


<210>  24607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24607
ugugccucag ccucccaagu                                                   20


<210>  24608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24608
agcgauucuu gugccucagc                                                   20


<210>  24609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24609
acaagcaacu cccuaacauu                                                   20


<210>  24610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24610
uuuuccuccu cuacucccag                                                   20


<210>  24611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24611
uccucuacuc ccagugugac                                                   20


<210>  24612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24612
acaaaggcac agacaucucu                                                   20


<210>  24613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24613
cccaggagcc uccuugagag                                                   20


<210>  24614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24614
cuccaggcuc ccugggccuu                                                   20


<210>  24615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24615
aacaccugaa ugaaccuauc                                                   20


<210>  24616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24616
gguguuugaa gcgcugacug                                                   20


<210>  24617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24617
uucagguguu ugaagcgcug                                                   20


<210>  24618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24618
uuggauaggu ucauucaggu                                                   20


<210>  24619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24619
uuuuucuuug gauagguuca                                                   20


<210>  24620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24620
uuuuccuuuu ucuuuggaua                                                   20


<210>  24621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24621
uuccuuuucc uuuuucuuug                                                   20


<210>  24622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24622
uucuuuccuu uuccuuuuuc                                                   20


<210>  24623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24623
uccuucuuuc cuuuuccuuu                                                   20


<210>  24624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24624
uuucuuccuu cuuuccuuuu                                                   20


<210>  24625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24625
uuccuuucuu ccuucuuucc                                                   20


<210>  24626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24626
ucccucccuc ccucccuccc                                                   20


<210>  24627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24627
uuccucccuc ccucccuccc                                                   20


<210>  24628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24628
uuccuuccuc ccucccuccc                                                   20


<210>  24629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24629
uuccuuccuu ccucccuccc                                                   20


<210>  24630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24630
uuccuuccuu ccuuccuccc                                                   20


<210>  24631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24631
uccuuccuuc cuuccuuccu                                                   20


<210>  24632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24632
uucuuccuuc cuuccuuccu                                                   20


<210>  24633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24633
uucuuucuuc cuuccuuccu                                                   20


<210>  24634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24634
ucccuccuuu cuuucuuucu                                                   20


<210>  24635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24635
ucccucccuc ccuuccuccc                                                   20


<210>  24636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24636
uuccucccuc ccucccuucc                                                   20


<210>  24637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24637
gcucgcuccu uccuuccucc                                                   20


<210>  24638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24638
ucuagaugag gcugcugugu                                                   20


<210>  24639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24639
ccauacauua uugacuuagc                                                   20


<210>  24640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24640
aaggggcccc uuacuuaugu                                                   20


<210>  24641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24641
aguuagaacg cuacugaaug                                                   20


<210>  24642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24642
aacuagaacu cuuugucucu                                                   20


<210>  24643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24643
guagcguucu aacuagaacu                                                   20


<210>  24644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24644
uucaguagcg uucuaacuag                                                   20


<210>  24645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24645
uaauauugac aucaaagaca                                                   20


<210>  24646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24646
uuggacuggc agcauugccc                                                   20


<210>  24647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24647
uaaugcaaua aucagcacac                                                   20


<210>  24648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24648
uguauguggu gauaggauuu                                                   20


<210>  24649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24649
auucauuuuc ccccaaaacu                                                   20


<210>  24650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24650
uuuuccccca aaacuaauaa                                                   20


<210>  24651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24651
cccaaaacua auaaggcuuu                                                   20


<210>  24652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24652
aagagugugu uuaaacauaa                                                   20


<210>  24653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24653
caccaaggau ggugagcuca                                                   20


<210>  24654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24654
gagcucacca uccuuggugg                                                   20


<210>  24655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24655
agauaaucuu uucugagcuc                                                   20


<210>  24656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24656
gcugcucuga uauucgagau                                                   20


<210>  24657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24657
aucgucucca gcagcauaca                                                   20


<210>  24658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24658
aaauaagcca guaucaauaa                                                   20


<210>  24659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24659
uuuuuuuuuu aacauugcuu                                                   20


<210>  24660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24660
caaaugagac uacuuuuaaa                                                   20


<210>  24661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24661
uuuaaaagua gucucauuug                                                   20


<210>  24662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24662
aacuugauuc ucuaugcuuc                                                   20


<210>  24663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24663
cuaugcuucc cuaccccaug                                                   20


<210>  24664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24664
cuaccccaug caucuuuuac                                                   20


<210>  24665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24665
cuugcuaaag guaaaagaug                                                   20


<210>  24666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24666
aacccaaucu uaaaaacaac                                                   20


<210>  24667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24667
ccuauaugcc ucucucuuuc                                                   20


<210>  24668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24668
cucucucucg uaaauaaaaa                                                   20


<210>  24669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24669
gcccaaugug auuuaaaaca                                                   20


<210>  24670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24670
auuauaaacc caaauuuuaa                                                   20


<210>  24671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24671
uuauagcagu gucuggcagg                                                   20


<210>  24672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24672
uuacuauaga ggcacuauag                                                   20


<210>  24673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24673
auuauaaacc ccaaguuuaa                                                   20


<210>  24674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24674
acccagugcc auuuaaauag                                                   20


<210>  24675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24675
aguuaucagu ccagauguga                                                   20


<210>  24676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24676
caucuggacu gauaacuuga                                                   20


<210>  24677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24677
gccuuuuaua aaacaaguuc                                                   20


<210>  24678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24678
ucagcugagu uauucugccu                                                   20


<210>  24679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24679
cucucucucu cucucucucc                                                   20


<210>  24680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24680
cucucucucu aucucuucug                                                   20


<210>  24681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24681
guuucucucu cucucccucu                                                   20


<210>  24682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24682
cucucucucc cucucucucc                                                   20


<210>  24683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24683
ggaggagaga gagggagaga                                                   20


<210>  24684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24684
gaauguuuuu aguaguuuca                                                   20


<210>  24685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24685
gaaauguucu ggaggagaga                                                   20


<210>  24686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24686
gauggucuua uugccaacuu                                                   20


<210>  24687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24687
agcuaugacu ucacugccug                                                   20


<210>  24688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24688
cugccugaaa ggaaauuuua                                                   20


<210>  24689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24689
ggcagugaag ucauagcugg                                                   20


<210>  24690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24690
uuucaggcag ugaagucaua                                                   20


<210>  24691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24691
uacauauaua uaggcgcaca                                                   20


<210>  24692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24692
gugugugcgc cuauauauau                                                   20


<210>  24693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24693
uucugugugu gcgccuauau                                                   20


<210>  24694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24694
uuggcauaua gucuugauuu                                                   20


<210>  24695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24695
gugcuaccuu cugaugaaaa                                                   20


<210>  24696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24696
gaugaaaaag uaugaacuua                                                   20


<210>  24697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24697
ucagaaggua gcacagaaug                                                   20


<210>  24698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24698
uacuuuuuca ucagaaggua                                                   20


<210>  24699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24699
gguaaguuca uacuuuuuca                                                   20


<210>  24700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24700
uuucugguaa guucauacuu                                                   20


<210>  24701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24701
caucuuauuu cauaaaaggu                                                   20


<210>  24702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24702
uaaaagguac agcuuuccug                                                   20


<210>  24703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24703
uggcaucacu ugguuuguuu                                                   20


<210>  24704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24704
aaacaaacca agugaugcca                                                   20


<210>  24705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24705
cugcuugacu uugacuguug                                                   20


<210>  24706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24706
ucaaucuguc aacagucaaa                                                   20


<210>  24707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24707
ucaucaaucu gucaacaguc                                                   20


<210>  24708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24708
aaacucuggu ccaccggauu                                                   20


<210>  24709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24709
uauuauggug gugguauacc                                                   20


<210>  24710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24710
ucaugcauau acucagcauc                                                   20


<210>  24711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24711
ccaucaccau caccaccagu                                                   20


<210>  24712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24712
cuaauuaaca uguccaccag                                                   20


<210>  24713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24713
acugcccucu gguggacaug                                                   20


<210>  24714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24714
uccuauuucu acugcccucu                                                   20


<210>  24715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24715
aaccuuaccc caucuuucau                                                   20


<210>  24716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24716
ccaaaucuug uugcuuuaga                                                   20


<210>  24717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24717
aaagcaacaa gauuuggaga                                                   20


<210>  24718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24718
cuuuaacuug uccgccaccu                                                   20


<210>  24719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24719
cacagaaagg cccaccaaga                                                   20


<210>  24720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24720
gugugaaguc agugaccuua                                                   20


<210>  24721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24721
gaaaucuuuu cacuuucaga                                                   20


<210>  24722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24722
gaaugcagau gugguugcug                                                   20


<210>  24723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24723
cuuucagaag agcaguuccu                                                   20


<210>  24724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24724
gaagagcagu uccuuuccuc                                                   20


<210>  24725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24725
gaaagugaaa agauuucuga                                                   20


<210>  24726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24726
uuuccucuau ucccucugac                                                   20


<210>  24727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24727
ucuauucccu cugacuggga                                                   20


<210>  24728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24728
cucugacugg gaucagacca                                                   20


<210>  24729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24729
cacuucacaa uagcuuuagu                                                   20


<210>  24730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24730
caauagcuuu aguuggucuc                                                   20


<210>  24731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24731
agaggagacc aacuaaagcu                                                   20


<210>  24732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24732
augagugaca aaagggaagc                                                   20


<210>  24733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24733
cuuuugucac ucauugaauu                                                   20


<210>  24734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24734
uucucuacca gugucucaua                                                   20


<210>  24735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24735
cuaccagugu cucauaaacc                                                   20


<210>  24736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24736
gcuggagugg uuaugggguu                                                   20


<210>  24737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24737
cagagagcac ugcacagccc                                                   20


<210>  24738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24738
ggucccuucu cuagaaauua                                                   20


<210>  24739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24739
cuagaaauua agacuuuuuu                                                   20


<210>  24740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24740
agagaaggga ccagaauagu                                                   20


<210>  24741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24741
ugucaaauuc agcaaaggga                                                   20


<210>  24742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24742
gcaaagggaa cuuuucuagg                                                   20


<210>  24743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24743
cuuugcugaa uuugacaaga                                                   20


<210>  24744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24744
aggagaaaau accuaucccu                                                   20


<210>  24745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24745
ccuagaaaag uucccuuugc                                                   20


<210>  24746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24746
uuggcagcuu aguagagaau                                                   20


<210>  24747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24747
cuacuaagcu gccaaagaaa                                                   20


<210>  24748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24748
cccauuccca guugcacaca                                                   20


<210>  24749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24749
caguugcaca caauuugccu                                                   20


<210>  24750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24750
cuuucucuua aaaaaaaaaa                                                   20


<210>  24751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24751
cuuaaaaaaa aaaaauccuu                                                   20


<210>  24752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24752
guuaucugaa ccuccagauu                                                   20


<210>  24753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24753
gauaacugaa cuugugcaag                                                   20


<210>  24754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24754
uauaaaauga agaaucuggu                                                   20


<210>  24755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24755
uuuuauagga aucuggaggu                                                   20


<210>  24756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24756
ucauuuuaua ggaaucugga                                                   20


<210>  24757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24757
uaggaccaga uucuucauuu                                                   20


<210>  24758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24758
uuccuucuuu auggagcacu                                                   20


<210>  24759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24759
uucuuuaugg agcacugcac                                                   20


<210>  24760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24760
uuauggagca cugcacugug                                                   20


<210>  24761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24761
ccagucacac augccaaagc                                                   20


<210>  24762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24762
uauuacuaau uugagcgguu                                                   20


<210>  24763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24763
aaaccuauag cgaggaucua                                                   20


<210>  24764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24764
ggagaaaaac uugauuuccc                                                   20


<210>  24765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24765
ccagaaagua caaaucuggu                                                   20


<210>  24766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24766
cauaaaugag aaugguaaau                                                   20


<210>  24767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24767
cauuuauggg aaaucaaguu                                                   20


<210>  24768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24768
aauggcuuaa cuaguuacuu                                                   20


<210>  24769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24769
caaaaguaac uaguuaagcc                                                   20


<210>  24770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24770
gugcuaccac uuguuuugua                                                   20


<210>  24771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24771
uagcauguau uugugaaugu                                                   20


<210>  24772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24772
caaauacaug cuaggaauag                                                   20


<210>  24773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24773
ccucuggaau gcaguggcac                                                   20


<210>  24774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24774
agaggugaaa gagcgagacu                                                   20


<210>  24775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24775
gccuccaggu ucaagcaauu                                                   20


<210>  24776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24776
agcaauucuc ccucccucaa                                                   20


<210>  24777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24777
cccucccuca accuccugag                                                   20


<210>  24778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24778
cuauguuggc caggcuggcc                                                   20


<210>  24779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24779
aggccagccu ggccaacaua                                                   20


<210>  24780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24780
cuaacacaua guaggcacuu                                                   20


<210>  24781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24781
ugaaucaagg aaugaauucc                                                   20


<210>  24782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24782
ggaaauguau uaagugccua                                                   20


<210>  24783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24783
uugauucagg aaauguauua                                                   20


<210>  24784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24784
uuccuugauu caggaaaugu                                                   20


<210>  24785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24785
acaaauauau uuucaguugc                                                   20


<210>  24786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24786
guugcugcug ccagugaaaa                                                   20


<210>  24787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24787
cuggcagcag caacugaaaa                                                   20


<210>  24788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24788
auuauugagu acuuauuagu                                                   20


<210>  24789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24789
uuuuuuaaau aguuaagaaa                                                   20


<210>  24790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24790
uaacuauuua aaaaaugaaa                                                   20


<210>  24791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24791
aucaggggga aacaauuaca                                                   20


<210>  24792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24792
cccugaugga agugggugug                                                   20


<210>  24793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24793
auauaauauc uguguauaua                                                   20


<210>  24794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24794
ucuuucucuc ccucagcaca                                                   20


<210>  24795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24795
cucccucagc acagaguaga                                                   20


<210>  24796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24796
acucugugcu gagggagaga                                                   20


<210>  24797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24797
uaagguucua cucugugcug                                                   20


<210>  24798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24798
uguaccagac auuuuccuaa                                                   20


<210>  24799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24799
caggaacuuc aaaauccuau                                                   20


<210>  24800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24800
ugggaaucua agugguuuac                                                   20


<210>  24801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24801
aaauccuauc uaccauagac                                                   20


<210>  24802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24802
caauucucag auuuugaaau                                                   20


<210>  24803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24803
cagauuuuga aaugcagcaa                                                   20


<210>  24804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24804
aaaucugaga auugagaaca                                                   20


<210>  24805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24805
aacagccaaa uuucaagagc                                                   20


<210>  24806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24806
agagcaucau aacagaguaa                                                   20


<210>  24807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24807
ggaggcugau ucuccagaca                                                   20


<210>  24808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24808
ccagacacua cguucuuuaa                                                   20


<210>  24809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24809
uuaaauauca agaccugucu                                                   20


<210>  24810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24810
uuugcaacag gcaaagcuca                                                   20


<210>  24811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24811
cauacacccc caaacaguga                                                   20


<210>  24812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24812
ggccuggcuc agggagcaag                                                   20


<210>  24813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24813
cuugcucccu gagccaggcc                                                   20


<210>  24814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24814
uuacucauca uaugucaaga                                                   20


<210>  24815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24815
cuucucaaaa uauugaaucu                                                   20


<210>  24816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24816
caaaauauug aaucuugaac                                                   20


<210>  24817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24817
auauuuugag aagagaaggu                                                   20


<210>  24818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24818
agauucaaua uuuugagaag                                                   20


<210>  24819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24819
gacuacaaau auauuagggg                                                   20


<210>  24820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24820
ccuaauauau uuguagucag                                                   20


<210>  24821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24821
aauaauguau augcuuuccc                                                   20


<210>  24822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24822
agaaaauuuu aaauaugcuc                                                   20


<210>  24823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24823
agaaccuuua aaucaauaca                                                   20


<210>  24824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24824
uauaaaacau guuuuaaaau                                                   20


<210>  24825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24825
ugggaacaug cagcuuucca                                                   20


<210>  24826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24826
caugaaggag aguugauuuc                                                   20


<210>  24827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24827
auuuuuuuuc uuuuauuuua                                                   20


<210>  24828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24828
uuuauuuuag cauaaauaaa                                                   20


<210>  24829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24829
uuuuugguug gaggcugccu                                                   20


<210>  24830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24830
uuuaaaaaaa aauuauauga                                                   20


<210>  24831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24831
gaauuccaag auggaucguu                                                   20


<210>  24832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24832
gaagacauua cuaaagcuaa                                                   20


<210>  24833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24833
aagauggauc guuucuuucc                                                   20


<210>  24834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24834
uuccacugau guucacauuu                                                   20


<210>  24835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24835
acugauguuc acauuuaagg                                                   20


<210>  24836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24836
cauuuaaggg gcuggaucuc                                                   20


<210>  24837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24837
uggucacauu aaguuaaaga                                                   20


<210>  24838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24838
uucuugguca cauuaaguua                                                   20


<210>  24839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24839
gcuauuuuac ccucaguaag                                                   20


<210>  24840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24840
auacuuacaa uuuuuaaaca                                                   20


<210>  24841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24841
aaaauguuua aaaauuguaa                                                   20


<210>  24842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24842
uucuaaaaug uuuaaaaauu                                                   20


<210>  24843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24843
uccuucuaaa auguuuaaaa                                                   20


<210>  24844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24844
guugguaucu uuuauuaauu                                                   20


<210>  24845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24845
uaaaaaaauu aauaaaagau                                                   20


<210>  24846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24846
ugguuguugg uuaaucucuc                                                   20


<210>  24847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24847
acacaauacc aaaugccuaa                                                   20


<210>  24848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24848
gugcaaguuu acauacaaug                                                   20


<210>  24849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24849
gugaaaauuu ccccggccag                                                   20


<210>  24850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24850
cugaaauaau uacugccauc                                                   20


<210>  24851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24851
ccggccagag uaacaagcag                                                   20


<210>  24852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24852
accucucagu guaacauuag                                                   20


<210>  24853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24853
uguauucuac cucucagugu                                                   20


<210>  24854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24854
cuuaucaccc auuagucacc                                                   20


<210>  24855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24855
gcuugcuguu ugggcauuua                                                   20


<210>  24856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24856
ggaaaaauua uuuuuauccu                                                   20


<210>  24857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24857
ugaaauuagg uuuuacauaa                                                   20


<210>  24858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24858
augcaaaugc cuaucaaaau                                                   20


<210>  24859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24859
cugcaucuua cccuuucuau                                                   20


<210>  24860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24860
acaagacacg gccuucucug                                                   20


<210>  24861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24861
acuaucauga aggaugugcu                                                   20


<210>  24862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24862
ugauagugga auuccacaag                                                   20


<210>  24863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24863
auaagcacug uguacaccgg                                                   20


<210>  24864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24864
uuuaaauggc cgguguacac                                                   20


<210>  24865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24865
uuuucuuuua aauggccggu                                                   20


<210>  24866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24866
uauuuuauca caagucuauu                                                   20


<210>  24867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24867
ggugaagaua cagggaggaa                                                   20


<210>  24868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24868
ccagaaccuc uuucuuauuu                                                   20


<210>  24869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24869
ucccuguauc uucaccagaa                                                   20


<210>  24870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24870
gagucauccu gcuuccuccc                                                   20


<210>  24871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24871
gucucauccu cccugaaugu                                                   20


<210>  24872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24872
gggaggauga gacugaagcu                                                   20


<210>  24873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24873
uguguccaag uaucaccaac                                                   20


<210>  24874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24874
uauacucuuu aguuggugau                                                   20


<210>  24875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24875
guuuagugag agauuucaua                                                   20


<210>  24876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24876
ccagggguuu caguuuagug                                                   20


<210>  24877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24877
ggguguaauu ucaauuauga                                                   20


<210>  24878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24878
auuaugaugc ugacuuuugg                                                   20


<210>  24879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24879
agagagcaag cagaguaaca                                                   20


<210>  24880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24880
ggaugccaga uuuuuguuac                                                   20


<210>  24881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24881
acaaagagga ucggucaaga                                                   20


<210>  24882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24882
ugaccgaucc ucuuugugga                                                   20


<210>  24883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24883
gcccuucuug accgauccuc                                                   20


<210>  24884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24884
uucagcccuu cuugaccgau                                                   20


<210>  24885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24885
aaggauaccu uugauauacc                                                   20


<210>  24886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24886
uuuuuauugg cucugaguuc                                                   20


<210>  24887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24887
cuucugagac cuaauuaacu                                                   20


<210>  24888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24888
gagaccuaau uaacuuuuau                                                   20


<210>  24889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24889
uugcuuauga ugagaacuaa                                                   20


<210>  24890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24890
caucauaagc aaagaacaaa                                                   20


<210>  24891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24891
auggcacaua uauuguuuua                                                   20


<210>  24892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24892
ucgccuguaa ggaauuuucu                                                   20


<210>  24893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24893
uuacaggcga ggaaaagcca                                                   20


<210>  24894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24894
guucuuuaga gguagucagg                                                   20


<210>  24895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24895
uuagagguag ucaggcaaug                                                   20


<210>  24896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24896
uugccugacu accucuaaag                                                   20


<210>  24897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24897
caaaacauua aguauuuucc                                                   20


<210>  24898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24898
uauaucuauu uucaaggaau                                                   20


<210>  24899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24899
aggaaucagg gacuuagucc                                                   20


<210>  24900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24900
uugaaaauag auauaggaaa                                                   20


<210>  24901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24901
aaaauauucc uuucguaucc                                                   20


<210>  24902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24902
uuucguaucc uaaaacaaaa                                                   20


<210>  24903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24903
uauccuaaaa caaaacaaaa                                                   20


<210>  24904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24904
ggaaacaaau uucaugcuuc                                                   20


<210>  24905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24905
ugaauauuuu uguuuuuguu                                                   20


<210>  24906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24906
ugcuuccuug caaggauuag                                                   20


<210>  24907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24907
uugcaaggau uagucuccua                                                   20


<210>  24908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24908
uguuuuaaag gaggauauau                                                   20


<210>  24909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24909
guuaccuuuc cugacuguaa                                                   20


<210>  24910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24910
ugacuguaaa gcaaucacag                                                   20


<210>  24911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24911
ugugauugcu uuacagucag                                                   20


<210>  24912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24912
gagagauaac uguuuucagu                                                   20


<210>  24913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24913
gugguuaugc cuccaaguag                                                   20


<210>  24914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24914
cuuacuacuu ggaggcauaa                                                   20


<210>  24915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24915
uguuucccuu acuacuugga                                                   20


<210>  24916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24916
uccuacuuuc aaguaauucg                                                   20


<210>  24917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24917
aguaauucgu auguuggugg                                                   20


<210>  24918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24918
uauguuggug gugcccccug                                                   20


<210>  24919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24919
uggacaaccu gugauugcag                                                   20


<210>  24920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24920
cccuuucuug gacaaccugu                                                   20


<210>  24921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24921
gaagcauuua gaucugguua                                                   20


<210>  24922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24922
gaauuuuauu cucccuuucu                                                   20


<210>  24923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24923
cauauuaacc agaucuaaau                                                   20


<210>  24924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24924
ccugcuccag gaacagccau                                                   20


<210>  24925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24925
uggagcaggg gaagugggca                                                   20


<210>  24926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24926
gaguuccucc cgucagccac                                                   20


<210>  24927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24927
ucccgucagc cacaguucca                                                   20


<210>  24928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24928
acuuuaaaca uuccucaacc                                                   20


<210>  24929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24929
ucaaccuaaa aucuggaaau                                                   20


<210>  24930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24930
agauuuuagg uugaggaaug                                                   20


<210>  24931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24931
aagaaugaaa uguuuuaaga                                                   20


<210>  24932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24932
uugaaaaugg uguuugggau                                                   20


<210>  24933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24933
uucuuugaaa augguguuug                                                   20


<210>  24934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24934
uaaaacauuu cauucuuuga                                                   20


<210>  24935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24935
uagagguuac cuaaugauaa                                                   20


<210>  24936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24936
gaauuagaag aauuuccugc                                                   20


<210>  24937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24937
gaauuuauua ucauuaggua                                                   20


<210>  24938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24938
aauucagaau uuauuaucau                                                   20


<210>  24939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24939
ucuaauucag aauuuauuau                                                   20


<210>  24940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24940
ugccacuuac uaggacauua                                                   20


<210>  24941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24941
aauguccuag uaaguggcag                                                   20


<210>  24942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24942
guucuaaugu ccuaguaagu                                                   20


<210>  24943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24943
cuuucuguuc uaauguccua                                                   20


<210>  24944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24944
uuuaauagau aaagccauuu                                                   20


<210>  24945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24945
aaauaaaaug aaauaaaaua                                                   20


<210>  24946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24946
uuuuauuuug aauaucaaaa                                                   20


<210>  24947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24947
uuuauuuauu uuauuucauu                                                   20


<210>  24948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24948
augugccuaa cuugguuguu                                                   20


<210>  24949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24949
uauuaagaug ggcagggcgg                                                   20


<210>  24950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24950
gucagcuacc ccccgcccug                                                   20


<210>  24951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24951
guucugucag cuaccccccg                                                   20


<210>  24952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24952
gaccugugau ggucuauuga                                                   20


<210>  24953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24953
auagaccauc acaggucuga                                                   20


<210>  24954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24954
ggcaauuuaa aaaugcauau                                                   20


<210>  24955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24955
caugacagaa ucuaaugggu                                                   20


<210>  24956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24956
gucaugugaa uauauauuca                                                   20


<210>  24957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24957
auaaaagugu augugauuug                                                   20


<210>  24958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24958
uauuuaaauu cuaaaguuga                                                   20


<210>  24959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24959
aaaguugaaa uagauaaaag                                                   20


<210>  24960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24960
acuuuagaau uuaaauaaga                                                   20


<210>  24961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24961
uuuuaucuau uucaacuuua                                                   20


<210>  24962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24962
uuugguaggu uuaauuuccu                                                   20


<210>  24963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24963
gagccaccaa ggcaagccuu                                                   20


<210>  24964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24964
ucaaggcuug ccuugguggc                                                   20


<210>  24965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24965
guuagacuca ccucaaucuu                                                   20


<210>  24966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24966
ccaaggcccc acacucccua                                                   20


<210>  24967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24967
uaaaacugau guuaaaaaau                                                   20


<210>  24968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24968
guauguagcc acggugagau                                                   20


<210>  24969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24969
aacuucagua uguagccacg                                                   20


<210>  24970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24970
acuuagcucu guacuucuuu                                                   20


<210>  24971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24971
uuuccauauu cagaucuuua                                                   20


<210>  24972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24972
auauucagau cuuuacagcu                                                   20


<210>  24973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24973
gaucuuuaca gcuacagcaa                                                   20


<210>  24974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24974
ucaguccucc acuuugcugu                                                   20


<210>  24975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24975
gcaaugagcc ugccuuuauc                                                   20


<210>  24976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24976
uggauggugc agauaaaggc                                                   20


<210>  24977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24977
cuccuugugg gcccucaggu                                                   20


<210>  24978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24978
cucccuuucu cuccuugugg                                                   20


<210>  24979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24979
gccugguaaa uagcauccac                                                   20


<210>  24980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24980
aauuaguucu gccugguaaa                                                   20


<210>  24981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24981
ucacccaaaa cuuaaacaag                                                   20


<210>  24982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24982
ccugaucaua uagagugaug                                                   20


<210>  24983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24983
guggcaguaa aaccuggagu                                                   20


<210>  24984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24984
ccuucugugg caguaaaacc                                                   20


<210>  24985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24985
aacaguucac cuucuguggc                                                   20


<210>  24986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24986
uuuucuaaca guucaccuuc                                                   20


<210>  24987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24987
caacugcugu uuugugcaug                                                   20


<210>  24988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24988
auucccaacu gcuguuuugu                                                   20


<210>  24989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24989
cagaaccccu gccauauacg                                                   20


<210>  24990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24990
gggaaagagg agcuuccauu                                                   20


<210>  24991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24991
agacacuccg uacaaccauu                                                   20


<210>  24992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24992
aucuauugaa ucaagagacu                                                   20


<210>  24993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24993
auagauugaa ugguuguacg                                                   20


<210>  24994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24994
aaauuuauua acccuuggag                                                   20


<210>  24995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24995
uuaagauaug gcugugcugu                                                   20


<210>  24996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24996
uuaugauaau uggggggaga                                                   20


<210>  24997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24997
gacagucucu cuccccccaa                                                   20


<210>  24998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24998
caggcaaacc ucagccuagg                                                   20


<210>  24999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  24999
cuucacaggc aaaccucagc                                                   20


<210>  25000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25000
ccagaaacag uucagucucu                                                   20


<210>  25001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25001
ggagaaaauu ucacuucaca                                                   20


<210>  25002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25002
gucucugaaa acaaugcaaa                                                   20


<210>  25003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25003
gagacugaac uguuucugga                                                   20


<210>  25004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25004
uuuugcauug uuuucagaga                                                   20


<210>  25005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25005
cccuccucuu uuuccuuuug                                                   20


<210>  25006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25006
ucccccuccu cuuuuuccuu                                                   20


<210>  25007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25007
ucuucccccu ccucuuuuuc                                                   20


<210>  25008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25008
cuuucuucuu cccccuccuc                                                   20


<210>  25009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25009
aaugguccaa agccagaaag                                                   20


<210>  25010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25010
ggcuuuggac cauuggaaau                                                   20


<210>  25011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25011
agccaguguc aaccccuaau                                                   20


<210>  25012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25012
uuaggcauua cauuaggggu                                                   20


<210>  25013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25013
aaaggcacac accugggaaa                                                   20


<210>  25014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25014
caggugugug ccuuuggaaa                                                   20


<210>  25015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25015
uccaguaagu caaacuucug                                                   20


<210>  25016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25016
gaaucaauaa ggaucagcua                                                   20


<210>  25017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25017
gaaguuugac uuacuggagg                                                   20


<210>  25018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25018
agcaauagcu gauccuuauu                                                   20


<210>  25019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25019
uuccagcaau agcugauccu                                                   20


<210>  25020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25020
ccuccccucc cccaaagaag                                                   20


<210>  25021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25021
uugggggagg ggaggugaaa                                                   20


<210>  25022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25022
ucuuuggggg aggggaggug                                                   20


<210>  25023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25023
aauugcuuag aguucuucuu                                                   20


<210>  25024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25024
cccccucccc uuuagcagga                                                   20


<210>  25025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25025
uuuaauaugu uagucugucu                                                   20


<210>  25026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25026
gauaaaaaaa agauauccau                                                   20


<210>  25027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25027
acuugcccau uacugauguu                                                   20


<210>  25028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25028
uagcuuuucu uucagacaca                                                   20


<210>  25029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25029
uucagacaca aacugcuagg                                                   20


<210>  25030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25030
gacacaaacu gcuaggcaug                                                   20


<210>  25031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25031
gaugaagcga uuucauucug                                                   20


<210>  25032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25032
ucugaaugcu aaaauuguua                                                   20


<210>  25033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25033
uucugugacu gccuuuucua                                                   20


<210>  25034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25034
gugacugccu uuucuauuag                                                   20


<210>  25035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25035
auuagauuug auuuugagaa                                                   20


<210>  25036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25036
caaaaucaaa ucuaauagaa                                                   20


<210>  25037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25037
aggcagagau cuaucuguga                                                   20


<210>  25038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25038
ugagaccccg cuccaucugg                                                   20


<210>  25039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25039
accacccccc cuccuuuuuu                                                   20


<210>  25040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25040
uagucaacau ugaucaaggc                                                   20


<210>  25041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25041
gccuugauca auguugacua                                                   20


<210>  25042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25042
aggagacgag gcgcuccguu                                                   20


<210>  25043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25043
ccugagucug cccagcccuu                                                   20


<210>  25044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25044
guauauggaa augaucaagc                                                   20


<210>  25045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25045
auauacugaa augugcuguu                                                   20


<210>  25046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25046
uucaccucca aagauuuuuu                                                   20


<210>  25047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25047
ccuccaaaga uuuuuuuucu                                                   20


<210>  25048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25048
cccucccaac agggauuuau                                                   20


<210>  25049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25049
ccaacaccug gaaauuauca                                                   20


<210>  25050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25050
agguguuggg gaaagccguu                                                   20


<210>  25051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25051
ugcuugcuga augaugcuaa                                                   20


<210>  25052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25052
gcaagcagga agcuugauaa                                                   20


<210>  25053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25053
uuuuuaacaa cucacuggcu                                                   20


<210>  25054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25054
uuaauaaaaa ucuaccaaag                                                   20


<210>  25055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25055
agucagauuu gauuuuggua                                                   20


<210>  25056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25056
agauagaugg guuuuuccau                                                   20


<210>  25057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25057
aucucugaau ucugaccccu                                                   20


<210>  25058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25058
gagauggaaa aacccaucua                                                   20


<210>  25059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25059
gaccccuuuu uuaaccauca                                                   20


<210>  25060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25060
cugacucucc ucucucccuc                                                   20


<210>  25061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25061
cucuccucug ugucucuuuu                                                   20


<210>  25062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25062
aucuguuucu cucuccucug                                                   20


<210>  25063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25063
aguguuacau cguuaccucu                                                   20


<210>  25064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25064
agcuccauuc aaguguuaca                                                   20


<210>  25065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25065
cuccucccua ggccacauuc                                                   20


<210>  25066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25066
uccuuuccca aagacccaca                                                   20


<210>  25067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25067
caaagaccca cacgaacguc                                                   20


<210>  25068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25068
ugugggucuu ugggaaagga                                                   20


<210>  25069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25069
ccagaucacc cacuagagua                                                   20


<210>  25070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25070
uuccuccucu ucucucugua                                                   20


<210>  25071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25071
uccucuucuc ucuguaucag                                                   20


<210>  25072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25072
cucuguauca ggggcugggu                                                   20


<210>  25073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25073
uuugagcugc ugccgccgcu                                                   20


<210>  25074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25074
auauauggaa augaccagag                                                   20


<210>  25075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25075
auauauugaa augcgcccaa                                                   20


<210>  25076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25076
gcaauaaauc agcacucaac                                                   20


<210>  25077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25077
aguucugcuu cauuuuccua                                                   20


<210>  25078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25078
gcuucauuuu ccuauuuucc                                                   20


<210>  25079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25079
uuuuccuauu uuccucuucu                                                   20


<210>  25080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25080
uauuuuccuc uucuccucac                                                   20


<210>  25081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25081
ucuucuccuc acagaagccu                                                   20


<210>  25082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25082
ccucacagaa gccucauuuc                                                   20


<210>  25083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25083
gugaggagaa gaggaaaaua                                                   20


<210>  25084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25084
ugcauuuugc cuugccgcgu                                                   20


<210>  25085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25085
cacuuccaac cuacacccuc                                                   20


<210>  25086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25086
aaccuacacc cucuccaaau                                                   20


<210>  25087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25087
guucucuggc uccccuguaa                                                   20


<210>  25088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25088
cuggcucccc uguaauugga                                                   20


<210>  25089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25089
aauuacaggg gagccagaga                                                   20


<210>  25090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25090
uuuucuuucc cuuucaaaaa                                                   20


<210>  25091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25091
uucccuuuca aaaaauuuuc                                                   20


<210>  25092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25092
cuuucaaaaa auuuuccgac                                                   20


<210>  25093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25093
aaaaauuuuc cgacaaaauc                                                   20


<210>  25094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25094
gacaaaauca ggcaguauuu                                                   20


<210>  25095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25095
cauccugggg auuacaugag                                                   20


<210>  25096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25096
uuaucauaag gggcuugagg                                                   20


<210>  25097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25097
uuuuucuuua ucauaagggg                                                   20


<210>  25098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25098
uuaccccagc ccccacucca                                                   20


<210>  25099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25099
cuuagcaaac uuaaaagacu                                                   20


<210>  25100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25100
gauagucuuu uaaguuugcu                                                   20


<210>  25101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25101
ggcuagccau ccagcgcucu                                                   20


<210>  25102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25102
ucuggcuagc cauccagcgc                                                   20


<210>  25103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25103
cuuuucuucu ggcuagccau                                                   20


<210>  25104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25104
acuacaaccu ucccuuuucu                                                   20


<210>  25105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25105
ugcuuuucuu guguagagcc                                                   20


<210>  25106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25106
uguguagagc cuccggugcc                                                   20


<210>  25107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25107
aaaaagaccc gaggcauugg                                                   20


<210>  25108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25108
caggagcuaa acgcagccug                                                   20


<210>  25109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25109
ggcugcguuu agcuccugag                                                   20


<210>  25110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25110
uggcgcgugc aaaaaaaaaa                                                   20


<210>  25111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25111
ccuuuuuuuu uuuuuuugca                                                   20


<210>  25112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25112
ggaguuuuuu uuuuuuuuuu                                                   20


<210>  25113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25113
guucagaagc aaacgcuacc                                                   20


<210>  25114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25114
gaagcaaacg cuaccuaguu                                                   20


<210>  25115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25115
gaaccgaacu aaaaaaaaaa                                                   20


<210>  25116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25116
uccacucccu cccagauccu                                                   20


<210>  25117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25117
acucccuccc agauccuacu                                                   20


<210>  25118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25118
acuugggucu cuguuuugcc                                                   20


<210>  25119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25119
uucucuugga ucuaggaaca                                                   20


<210>  25120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25120
cuuggaucua ggaacaauag                                                   20


<210>  25121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25121
uagauccaag agaaagaaaa                                                   20


<210>  25122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25122
gagcuuuaua gggugaugcc                                                   20


<210>  25123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25123
uuuaauaaaa uuaauuaggu                                                   20


<210>  25124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25124
cccaggcugu cauauugcau                                                   20


<210>  25125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25125
auccucacau cauaagcuua                                                   20


<210>  25126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25126
ugccccauuu gauccugggc                                                   20


<210>  25127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25127
caaggucaaa caaaaaccag                                                   20


<210>  25128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25128
gacaagcucu ucacaagguc                                                   20


<210>  25129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25129
gcacaauugg agggacaccc                                                   20


<210>  25130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25130
gggugucccu ccaauugugc                                                   20


<210>  25131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25131
cauugccaga cggcaguuga                                                   20


<210>  25132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25132
acugccgucu ggcaauggga                                                   20


<210>  25133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25133
uaguuuguug ucgugacagc                                                   20


<210>  25134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25134
aaauagugag agcuuugggg                                                   20


<210>  25135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25135
cgcugcccca caccucccca                                                   20


<210>  25136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25136
ugaaaauaau cugcuuagaa                                                   20


<210>  25137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25137
agaaaauauc cacucuagga                                                   20


<210>  25138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25138
aagcagauua uuuucaagaa                                                   20


<210>  25139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25139
augaaaucca auaugccuuc                                                   20


<210>  25140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25140
uagaauguga uuucuaagca                                                   20


<210>  25141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25141
caagagcgaa ggaaaaugua                                                   20


<210>  25142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25142
cucuugagaa ggcauauugg                                                   20


<210>  25143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25143
uucgcucuug agaaggcaua                                                   20


<210>  25144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25144
ugccacucug guaauuugaa                                                   20


<210>  25145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25145
aauuaccaga guggcaggaa                                                   20


<210>  25146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25146
aggagguuau uaaaaaugua                                                   20


<210>  25147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25147
gacauauugu ucuuugacuu                                                   20


<210>  25148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25148
uugacuuaau aucccugugu                                                   20


<210>  25149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25149
uuaauugcca aaacaaaguu                                                   20


<210>  25150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25150
uuuacaaggg cuaacuguau                                                   20


<210>  25151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25151
uaggagauau acaguuagcc                                                   20


<210>  25152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25152
aaugucauag ucucaugguu                                                   20


<210>  25153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25153
acauggaucu agaaacguau                                                   20


<210>  25154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25154
agauccaugu ugaacaaaau                                                   20


<210>  25155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25155
auacauaugc uauacguuuc                                                   20


<210>  25156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25156
agagcucucu gaaggaaaau                                                   20


<210>  25157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25157
gagagcucuu gaauauuuua                                                   20


<210>  25158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25158
uucagagagc ucuugaauau                                                   20


<210>  25159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25159
agcacauuuu ccuucagaga                                                   20


<210>  25160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25160
auaaaagagg ggguuauuuu                                                   20


<210>  25161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25161
uuuuacuauc uauagaucua                                                   20


<210>  25162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25162
uucuuuuuac uaucuauaga                                                   20


<210>  25163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25163
uucauucuuu uuacuaucua                                                   20


<210>  25164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25164
caguuucuuu cauucuuuuu                                                   20


<210>  25165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25165
guguaauuca caguuucuuu                                                   20


<210>  25166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25166
uagcuuccau guuacagagc                                                   20


<210>  25167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25167
auguuacaga gcuuuaggaa                                                   20


<210>  25168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25168
uaaagcucug uaacauggaa                                                   20


<210>  25169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25169
gauugaagcu cugccuugua                                                   20


<210>  25170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25170
aucugaaagu uuggggacua                                                   20


<210>  25171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25171
agacaaaccu cagaccguac                                                   20


<210>  25172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25172
acacucaugu aauuuaacag                                                   20


<210>  25173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25173
ucuccaaacc uguuaaauua                                                   20


<210>  25174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25174
cacaacuguu gucauccuau                                                   20


<210>  25175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25175
aauauaugca guucuaacag                                                   20


<210>  25176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25176
aacagcuuuc auucuaagac                                                   20


<210>  25177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25177
uucuaagacg ccaaaccuuc                                                   20


<210>  25178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25178
aagacgccaa accuuccgaa                                                   20


<210>  25179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25179
gaaaauagaa uggcuuaaca                                                   20


<210>  25180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25180
gaagguuugg cgucuuagaa                                                   20


<210>  25181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25181
auuuucggaa gguuuggcgu                                                   20


<210>  25182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25182
uuuuuauauu aaaaguccaa                                                   20


<210>  25183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25183
cauaaaaugu uuuuuuauca                                                   20


<210>  25184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25184
accaaaaaag caaacaucuu                                                   20


<210>  25185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25185
agauguuugc uuuuuuggua                                                   20


<210>  25186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25186
cccagcuuuu uacagcuccc                                                   20


<210>  25187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25187
guacuauuuu caacugcccc                                                   20


<210>  25188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25188
acugccccuc ccccauauga                                                   20


<210>  25189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25189
aagugucuca uaugggggag                                                   20


<210>  25190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25190
aguguucaaa gugucucaua                                                   20


<210>  25191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25191
auaguaauua uuuuuauucc                                                   20


<210>  25192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25192
guguuucaau aguaauuauu                                                   20


<210>  25193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25193
aguucagugu uucaauagua                                                   20


<210>  25194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25194
caauauugcu aacaaaaucu                                                   20


<210>  25195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25195
cagacugcuc ucugauggaa                                                   20


<210>  25196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25196
aucagagagc agucugagaa                                                   20


<210>  25197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25197
ccuaguucca ucagagagca                                                   20


<210>  25198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25198
ccaauucucc uaguuccauc                                                   20


<210>  25199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25199
aagugcaguu uguuguuuua                                                   20


<210>  25200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25200
cauuuuuauu aaucaguaca                                                   20


<210>  25201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25201
aaauuuguaa cucaaauuau                                                   20


<210>  25202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25202
uaguucaaaa uuuguaacuc                                                   20


<210>  25203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25203
cccauuugag cagauggcga                                                   20


<210>  25204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25204
gcaauuuuug guuuuccccc                                                   20


<210>  25205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25205
caccucuuuu uuuuuuauga                                                   20


<210>  25206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25206
ugaauaauuu aaaaaagaaa                                                   20


<210>  25207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25207
ggaauguugu uuauguuauc                                                   20


<210>  25208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25208
uuuuuaaauu auucaggaau                                                   20


<210>  25209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25209
acaacugcuu ggugagucca                                                   20


<210>  25210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25210
caaacgugca auuauuuuuu                                                   20


<210>  25211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25211
uaauuacuua cauagguucu                                                   20


<210>  25212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25212
aucaaaagau ucagguucua                                                   20


<210>  25213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25213
gguucuagug cuuuucccac                                                   20


<210>  25214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25214
agugcuuuuc ccacauauug                                                   20


<210>  25215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25215
cacauauugu gcaaaucugc                                                   20


<210>  25216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25216
uacaggucuc ugacauaguu                                                   20


<210>  25217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25217
aaguauccuc ugggaguggg                                                   20


<210>  25218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25218
ccccacuccc agaggauacu                                                   20


<210>  25219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25219
uuucucccca cucccagagg                                                   20


<210>  25220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25220
uggagacuuu uuucuuuucu                                                   20


<210>  25221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25221
cuccaaguuu ggguucaugg                                                   20


<210>  25222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25222
uuguaucuau uuaucuauuu                                                   20


<210>  25223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25223
uuaucacaau ucuuuguauc                                                   20


<210>  25224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25224
cacaaaaaga uaagauaauu                                                   20


<210>  25225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25225
uucccacaaa aagauaagau                                                   20


<210>  25226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25226
gggcuauuga aagcaguugu                                                   20


<210>  25227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25227
auagcccuga auggcagauc                                                   20


<210>  25228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25228
acuggguccu ggaugccaga                                                   20


<210>  25229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25229
cccagcagaa gaaacagcag                                                   20


<210>  25230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25230
gcugggggaa uaguaaguuc                                                   20


<210>  25231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25231
ucugcugggg gaauaguaag                                                   20


<210>  25232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25232
gcuguuucuu cugcuggggg                                                   20


<210>  25233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25233
agcaaugaag augaugagcc                                                   20


<210>  25234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25234
uugcuugaau ccuuacaacu                                                   20


<210>  25235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25235
auuacacccc cuguaccaau                                                   20


<210>  25236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25236
acaugacaga uaaaacaagu                                                   20


<210>  25237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25237
ggcauccuaa aaauaaagaa                                                   20


<210>  25238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25238
uuauuuuuag gaugccugaa                                                   20


<210>  25239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25239
auucuauuaa ucacagaaua                                                   20


<210>  25240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25240
auuaaucaca gaauaauaug                                                   20


<210>  25241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25241
gugauuaaua gaauugaauu                                                   20


<210>  25242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25242
uuuccuuuuu uuuuuuuuua                                                   20


<210>  25243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25243
uuuuuuuuuu uuuuauuuuu                                                   20


<210>  25244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25244
uuaagagaag aaaacucuga                                                   20


<210>  25245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25245
cuuaaagaaa aauaaaaaaa                                                   20


<210>  25246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25246
ucucuuaaag aaaaauaaaa                                                   20


<210>  25247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25247
uauaaacaga cauuggcacc                                                   20


<210>  25248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25248
ggcuuuuuga ucuuggugcc                                                   20


<210>  25249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25249
cucccccugg caaaggguga                                                   20


<210>  25250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25250
guuucaguuc agguaaaaau                                                   20


<210>  25251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25251
guucagguaa aaaugagggu                                                   20


<210>  25252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25252
gguaaaaaug aggguguaaa                                                   20


<210>  25253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25253
caggccccug gaaugaugag                                                   20


<210>  25254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25254
aggggccugg gaauuuacac                                                   20


<210>  25255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25255
ucguguugga guuggguaga                                                   20


<210>  25256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25256
acccaacucc aacacgauga                                                   20


<210>  25257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25257
ucuacccaac uccaacacga                                                   20


<210>  25258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25258
uuuucuucua cccaacucca                                                   20


<210>  25259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25259
ucauuuucuu cuacccaacu                                                   20


<210>  25260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25260
agacgaccuu gaacaucagc                                                   20


<210>  25261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25261
aggucgucug gaagcauuuu                                                   20


<210>  25262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25262
acucaaagua uaauuccuug                                                   20


<210>  25263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25263
uugaacaugg cagcugcuac                                                   20


<210>  25264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25264
aggaauuaua cuuugaguag                                                   20


<210>  25265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25265
uucauaaaca aucucucuaa                                                   20


<210>  25266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25266
uaaacaaucu cucuaaacuu                                                   20


<210>  25267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25267
auaaguuuag agagauuguu                                                   20


<210>  25268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25268
auauucuaua aguuuagaga                                                   20


<210>  25269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25269
cauuauacac aauauucaau                                                   20


<210>  25270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25270
uauuucacau uauacacaau                                                   20


<210>  25271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25271
cuuauuuaga gucaguucaa                                                   20


<210>  25272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25272
auaccaggug cuuuugagua                                                   20


<210>  25273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25273
gauacucaaa agcaccuggu                                                   20


<210>  25274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25274
guccccucaa caugugacac                                                   20


<210>  25275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25275
uguuguuaac uugucuucgg                                                   20


<210>  25276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25276
ccagucagac uuguauguga                                                   20


<210>  25277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25277
cccgcuuugg ggcaccuccc                                                   20


<210>  25278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25278
acugcugggg aggaaugagu                                                   20


<210>  25279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25279
uccccagcag uugaaaauuc                                                   20


<210>  25280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25280
auguagcaaa gcccuacuca                                                   20


<210>  25281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25281
cacauuuucc auguagcaaa                                                   20


<210>  25282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25282
acucugagug cucuucucac                                                   20


<210>  25283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25283
gcuacaucag gcaagaugca                                                   20


<210>  25284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25284
ugucacucca cugugcuuca                                                   20


<210>  25285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25285
ccccagacuu gccccaaccu                                                   20


<210>  25286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25286
agguucuccc cagacuugcc                                                   20


<210>  25287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25287
cagccuugac cugaaucucu                                                   20


<210>  25288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25288
ggucaaggcu gugaaugacg                                                   20


<210>  25289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25289
uuugccuaga gauucagguc                                                   20


<210>  25290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25290
aaagagcaug ucacccagca                                                   20


<210>  25291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25291
auuuuuccaa agagcauguc                                                   20


<210>  25292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25292
cuaaauugcc uccagcuuuc                                                   20


<210>  25293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25293
agccauucuc uaaauugccu                                                   20


<210>  25294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25294
cugccauuca acuuauuuuu                                                   20


<210>  25295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25295
acuuauuuuu cuauuugcca                                                   20


<210>  25296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25296
auuugccagu cugcagagga                                                   20


<210>  25297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25297
ucugcagacu ggcaaauaga                                                   20


<210>  25298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25298
uuugcauaug ggccacuucc                                                   20


<210>  25299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25299
uggugagguc caaaucauuu                                                   20


<210>  25300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25300
uuccugguga gguccaaauc                                                   20


<210>  25301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25301
ccaucuucuc uuucauaauu                                                   20


<210>  25302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25302
cuuucauaau ugacgaugau                                                   20


<210>  25303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25303
uaauugacga ugaugcuucu                                                   20


<210>  25304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25304
gauggugauu ucuauuuaca                                                   20


<210>  25305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25305
auuuacauac acaggauggc                                                   20


<210>  25306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25306
gccauccugu guauguaaau                                                   20


<210>  25307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25307
cauagaaagu cuacucuuug                                                   20


<210>  25308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25308
augagaagau ucagccaucc                                                   20


<210>  25309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25309
aagaguagac uuucuaugag                                                   20


<210>  25310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25310
auaauuggac ugucuaagaa                                                   20


<210>  25311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25311
uagacagucc aauuauagaa                                                   20


<210>  25312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25312
uccuucccug ugggggcccc                                                   20


<210>  25313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25313
cugugggggc cccaaaaguu                                                   20


<210>  25314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25314
uaaauuugag ucuuaccuuu                                                   20


<210>  25315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25315
uucauaaauu ugagucuuac                                                   20


<210>  25316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25316
ccaccucuag gaagaaacac                                                   20


<210>  25317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25317
uagaggugga gaagagggau                                                   20


<210>  25318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25318
uccuagaggu ggagaagagg                                                   20


<210>  25319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25319
aguguuucuu ccuagaggug                                                   20


<210>  25320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25320
uucagcaucc acuauaugca                                                   20


<210>  25321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25321
gcauccacua uaugcacaac                                                   20


<210>  25322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25322
gcaaaagguu gugcauauag                                                   20


<210>  25323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25323
uuuaaaaaau gaacccaaau                                                   20


<210>  25324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25324
uuuuuuaaaa gaagauucag                                                   20


<210>  25325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25325
caauaucucu auuuggguuc                                                   20


<210>  25326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25326
uccuuguuuu cucaauaucu                                                   20


<210>  25327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25327
uuugauuuua gguaauguuu                                                   20


<210>  25328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25328
guuuuuacag ggcuggagag                                                   20


<210>  25329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25329
guaaguuggu cucuccagcc                                                   20


<210>  25330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25330
ugguuaaagu ucuguaaguu                                                   20


<210>  25331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25331
uggcucuugu cuuacuuuuc                                                   20


<210>  25332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25332
aguucuaucc aguagaaaau                                                   20


<210>  25333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25333
auccaguaga aaauaacagu                                                   20


<210>  25334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25334
acuggauaga acuagaaaag                                                   20


<210>  25335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25335
uacuguuauu uucuacugga                                                   20


<210>  25336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25336
aauagccuuc ugcuaauuag                                                   20


<210>  25337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25337
gcuaauuaga aaauuacccu                                                   20


<210>  25338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25338
aauuagcaga aggcuauuug                                                   20


<210>  25339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25339
uaagggcugc cagcauuguu                                                   20


<210>  25340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25340
guauauuagc agagccauau                                                   20


<210>  25341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25341
gccugcagug auuuuagcag                                                   20


<210>  25342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25342
caguccaggg cauggagcau                                                   20


<210>  25343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25343
aggcguguaa aacugacacc                                                   20


<210>  25344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25344
ucuuagcaca ccuuagcugu                                                   20


<210>  25345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25345
uagcacaccu uagcugugau                                                   20


<210>  25346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25346
gaucugggau cacagcuaag                                                   20


<210>  25347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25347
cuugagaaug aaggcugcuu                                                   20


<210>  25348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25348
caagagaacu ggguuccgau                                                   20


<210>  25349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25349
uucucaagag aacuggguuc                                                   20


<210>  25350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25350
uuacuaacau gucaaagcag                                                   20


<210>  25351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25351
cuuacaggau uuaguuaaaa                                                   20


<210>  25352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25352
gcuguauguu uacaauugau                                                   20


<210>  25353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25353
uauuaagaga uuuuauuuaa                                                   20


<210>  25354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25354
caugcauauc agcaaauauu                                                   20


<210>  25355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25355
auguauuaca uaauauuugc                                                   20


<210>  25356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25356
auuuugauau caaaguggau                                                   20


<210>  25357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25357
aaagucagac cauagguguu                                                   20


<210>  25358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25358
uaacauuuuu cuaaagucag                                                   20


<210>  25359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25359
uacuuccauu cuuaauuaug                                                   20


<210>  25360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25360
auucuuaauu augacuuggu                                                   20


<210>  25361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25361
uaauuaugac uugguauuau                                                   20


<210>  25362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25362
cuacuucaaa uaucaaacag                                                   20


<210>  25363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25363
aauaucaaac aguaaaagcu                                                   20


<210>  25364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25364
ugugucuuac auauucaugu                                                   20


<210>  25365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25365
ugucauacca cagggucaag                                                   20


<210>  25366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25366
ggcugaaagg uauuuuuuuu                                                   20


<210>  25367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25367
agguucaggc ugaaagguau                                                   20


<210>  25368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25368
cuuuaucugu uuaggguauu                                                   20


<210>  25369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25369
uaaauagcua uauuucugag                                                   20


<210>  25370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25370
gagauuuaac ucagaaaauu                                                   20


<210>  25371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25371
gaguuaaauc ucagaaauau                                                   20


<210>  25372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25372
uuugcuagcu guacuuucaa                                                   20


<210>  25373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25373
aaaaugguuu cucguuuaaa                                                   20


<210>  25374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25374
cguuuaaaca acuucuaguu                                                   20


<210>  25375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25375
aguucaacua aaaagugauu                                                   20


<210>  25376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25376
acuaaaaagu gauuauaccc                                                   20


<210>  25377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25377
uauuuaaauu acaggcccau                                                   20


<210>  25378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25378
uuucauccuu ggcaaaaauu                                                   20


<210>  25379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25379
uccuuggcaa aaauuaaaaa                                                   20


<210>  25380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25380
uagauagaga ugcuuuuaca                                                   20


<210>  25381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25381
aagcucugua agcauucauu                                                   20


<210>  25382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25382
uuagcuuagu uuccucccgu                                                   20


<210>  25383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25383
ucccguuagc uugcaauaaa                                                   20


<210>  25384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25384
cccucaaagu gcuuuacagg                                                   20


<210>  25385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25385
gcuuaauaaa cuagauuucu                                                   20


<210>  25386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25386
guuuacaauc aaagggaaaa                                                   20


<210>  25387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25387
cuuugauugu aaacagaaau                                                   20


<210>  25388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25388
aauuuucccu uugauuguaa                                                   20


<210>  25389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25389
ccuugcaaua aguaaaagag                                                   20


<210>  25390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25390
cuuagccaau uaaaaauuuc                                                   20


<210>  25391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25391
agguccuagg caaugaaaua                                                   20


<210>  25392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25392
uugccuagga ccuugaaauu                                                   20


<210>  25393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25393
ugucuguuug uuuuacuaau                                                   20


<210>  25394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25394
aauuaguaaa acaaacagac                                                   20


<210>  25395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25395
uuucaaauua guaaaacaaa                                                   20


<210>  25396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25396
aaauuuuuac ccccucaauu                                                   20


<210>  25397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25397
ugcaaaagga aacuugguuu                                                   20


<210>  25398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25398
uuuugcauga auaaauugag                                                   20


<210>  25399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25399
gauauuacag auuagacacc                                                   20


<210>  25400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25400
auuuguguuu auaagaacau                                                   20


<210>  25401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25401
uauaaacaca aauggaaaua                                                   20


<210>  25402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25402
agaggcuccc uuaccuccag                                                   20


<210>  25403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25403
auuccaaccu gagugggaac                                                   20


<210>  25404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25404
aaccugagug ggaacuguaa                                                   20


<210>  25405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25405
cacucagguu ggaauagaau                                                   20


<210>  25406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25406
aauguccugg aggccuuagg                                                   20


<210>  25407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25407
ugggcucugg cuuuagggca                                                   20


<210>  25408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25408
guagagauua ccuaucuugg                                                   20


<210>  25409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25409
ucuguagaga uuaccuaucu                                                   20


<210>  25410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25410
gagucuauag guaucaucua                                                   20


<210>  25411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25411
uauaaaaccc cacaccguuu                                                   20


<210>  25412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25412
aauugaccuu ccccaucuca                                                   20


<210>  25413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25413
ccaucucaug auaugcuguu                                                   20


<210>  25414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25414
cugaaaacua augcuuaguu                                                   20


<210>  25415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25415
gggaacagca uaucaugaga                                                   20


<210>  25416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25416
acuaagcauu aguuuucagg                                                   20


<210>  25417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25417
auuuugacuu uaccauccag                                                   20


<210>  25418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25418
caugaggaac aucugaaaug                                                   20


<210>  25419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25419
ucaugagaac ucuggauggu                                                   20


<210>  25420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25420
gauguuccuc augagaacuc                                                   20


<210>  25421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25421
ggagauuucu uugaagcagu                                                   20


<210>  25422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25422
uugaagcagu gcagaauaaa                                                   20


<210>  25423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25423
aagaaaucuc cagaagccug                                                   20


<210>  25424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25424
gcacugcuuc aaagaaaucu                                                   20


<210>  25425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25425
uuuuauucug cacugcuuca                                                   20


<210>  25426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25426
aucuuccuuu uauucugcac                                                   20


<210>  25427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25427
uaauguguug aagcuuucug                                                   20


<210>  25428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25428
agucaugccc uaugcuaucu                                                   20


<210>  25429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25429
uauuaucaua auuaccuaua                                                   20


<210>  25430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25430
agaccagccu ggccaacagg                                                   20


<210>  25431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25431
cccuguuggc caggcugguc                                                   20


<210>  25432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25432
uugaaacaua cuuucaucuc                                                   20


<210>  25433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25433
augaaaaaau auaugugugu                                                   20


<210>  25434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25434
ucucuuuuca cauugauuuu                                                   20


<210>  25435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25435
cauugauuuu ggcuuguuug                                                   20


<210>  25436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25436
guuguuuuuc uucuaacuga                                                   20


<210>  25437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25437
ucuaacugau aagaaugggg                                                   20


<210>  25438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25438
aacugauaag aaugggguag                                                   20


<210>  25439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25439
uaucaguuag aagaaaaaca                                                   20


<210>  25440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25440
aaggccucua aaccagucau                                                   20


<210>  25441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25441
aagcuuagcu cugaccaaau                                                   20


<210>  25442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25442
cuugcaggau cagaccuuaa                                                   20


<210>  25443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25443
cucaaacacc aaaauaaccu                                                   20


<210>  25444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25444
gguuauuuug guguuugaga                                                   20


<210>  25445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25445
ugagugcaua uuuuuaaaug                                                   20


<210>  25446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25446
cauaaauaag aguaggaggc                                                   20


<210>  25447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25447
ucgcauaaau aagaguagga                                                   20


<210>  25448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25448
aaguuaauuu uggucuuuuu                                                   20


<210>  25449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25449
accauuaaaa agaccaaaau                                                   20


<210>  25450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25450
guucaaccau uaaaaagacc                                                   20


<210>  25451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25451
gccuccaggg cuucuguuca                                                   20


<210>  25452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25452
ccuucaguuu aaaagcgcua                                                   20


<210>  25453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25453
guuuaaaagc gcuaauuucu                                                   20


<210>  25454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25454
gccuucuggg ugccuuuaua                                                   20


<210>  25455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25455
gggugccuuu auaacaacuu                                                   20


<210>  25456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25456
agugagaggg gaggaaagga                                                   20


<210>  25457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25457
uccccucuca cucgaaaguu                                                   20


<210>  25458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25458
ugcccaacuu ugcaauguua                                                   20


<210>  25459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25459
cauuccugcc caacuuugca                                                   20


<210>  25460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25460
auugcuuuuu uuuauguuuu                                                   20


<210>  25461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25461
gccacuuguu cagugacuuc                                                   20


<210>  25462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25462
gugacuucuu uucaucagga                                                   20


<210>  25463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25463
uuucaucagg aagguugcuu                                                   20


<210>  25464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25464
ucaggaaggu ugcuuuacau                                                   20


<210>  25465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25465
ugaugaaaag aagucacuga                                                   20


<210>  25466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25466
uggugcagca cauuuaaaua                                                   20


<210>  25467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25467
gguuuuuuuc aguugaaauu                                                   20


<210>  25468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25468
guugaaauua auauuugcua                                                   20


<210>  25469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25469
acugaaaaaa accagaaggc                                                   20


<210>  25470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25470
uuuauuagca aauauuaauu                                                   20


<210>  25471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25471
augaccugac aguucuuuua                                                   20


<210>  25472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25472
uugauguacc caaaagaaca                                                   20


<210>  25473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25473
uuuggguaca ucaaugaaug                                                   20


<210>  25474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25474
guucuuuugg guacaucaau                                                   20


<210>  25475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25475
uuucacaagc ccuauaugcu                                                   20


<210>  25476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25476
caagcccuau augcuccugg                                                   20


<210>  25477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25477
uauagccaac accuuaaacu                                                   20


<210>  25478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25478
cauggguuau gcugcaaucg                                                   20


<210>  25479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25479
uccggagucu ccccacuuua                                                   20


<210>  25480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25480
uaucuauuuc aggcauaaau                                                   20


<210>  25481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25481
ggcauaaaug gauucugaaa                                                   20


<210>  25482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25482
gaaauuuugu ggcuuaaaaa                                                   20


<210>  25483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25483
gaauccauuu augccugaaa                                                   20


<210>  25484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25484
uuuuuuuaag ccacaaaauu                                                   20


<210>  25485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25485
gugaacgcag cagaaacugc                                                   20


<210>  25486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25486
cggaacuuuu ucuuuuuuuu                                                   20


<210>  25487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25487
gcugcguuca cggaacuuuu                                                   20


<210>  25488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25488
acguugcagu uucugcugcg                                                   20


<210>  25489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25489
guguggagau cuggaagcac                                                   20


<210>  25490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25490
agaucuccac acugaaaugu                                                   20


<210>  25491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25491
uaccucagga agacccauac                                                   20


<210>  25492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25492
ugagguagga augcaaaggc                                                   20


<210>  25493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25493
auuauuguau gggucuuccu                                                   20


<210>  25494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25494
aggauuacca agucaauuac                                                   20


<210>  25495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25495
cccucucagu aauugacuug                                                   20


<210>  25496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25496
uuuuuauuuu ucucccucuc                                                   20


<210>  25497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25497
auucaaacag cucccaggga                                                   20


<210>  25498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25498
aacagcuccc agggaguuaa                                                   20


<210>  25499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25499
cucuauaugg ugaacagugu                                                   20


<210>  25500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25500
ccauauagag agaauuuuaa                                                   20


<210>  25501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25501
uuuggggucu acaccugcug                                                   20


<210>  25502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25502
guacaugccu gccucuugca                                                   20


<210>  25503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25503
aauuucggua caugccugcc                                                   20


<210>  25504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25504
caggcuauug uuuaacauuc                                                   20


<210>  25505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25505
acauauguga gauacagaau                                                   20


<210>  25506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25506
guaucucaca uauguagaau                                                   20


<210>  25507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25507
uucuguaucu cacauaugua                                                   20


<210>  25508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25508
uucauucugu aucucacaua                                                   20


<210>  25509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25509
cauucuuuca uucuguaucu                                                   20


<210>  25510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25510
caaggcaauc ucaagcuuua                                                   20


<210>  25511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25511
gacagauucu cuaacugaca                                                   20


<210>  25512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25512
cuaacugaca auuaauauua                                                   20


<210>  25513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25513
caauguggca uuaucacacg                                                   20


<210>  25514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25514
cccugagcca aguaaucccu                                                   20


<210>  25515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25515
auuucucccu gagccaagua                                                   20


<210>  25516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25516
ucuuuuguuu ggacgcagcu                                                   20


<210>  25517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25517
cccuuguucu uuauuugugg                                                   20


<210>  25518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25518
uuauuugugg ucggcaacau                                                   20


<210>  25519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25519
ccuggagaug uugccgacca                                                   20


<210>  25520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25520
uuuccccugg agauguugcc                                                   20


<210>  25521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25521
ggaugcuuua gaauagguaa                                                   20


<210>  25522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25522
aaagcaucca gaaauagacc                                                   20


<210>  25523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25523
auaugcccuu uuaccuauuc                                                   20


<210>  25524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25524
gguaccucaa gaaugccucg                                                   20


<210>  25525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25525
caaguuaccu gcagcagcaa                                                   20


<210>  25526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25526
acuuuugcuc ugaugaugag                                                   20


<210>  25527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25527
cacucaucau cagagcaaaa                                                   20


<210>  25528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25528
aacucaugaa aaaacacuuc                                                   20


<210>  25529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25529
ugaguuggaa ugucuuggug                                                   20


<210>  25530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25530
cauacagcau ggaucaugug                                                   20


<210>  25531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25531
gcgcgcaggg gcggccucgg                                                   20


<210>  25532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25532
ugcggacccg gcccacggcg                                                   20


<210>  25533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25533
cgccuccgcg ccuccggggg                                                   20


<210>  25534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25534
ugaucauggu auuuuuauuc                                                   20


<210>  25535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25535
acgcauaugc aagcaacuac                                                   20


<210>  25536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25536
agauauauuc cacgcauaug                                                   20


<210>  25537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25537
uuugugacgu uccagauaua                                                   20


<210>  25538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25538
aacuugguac auggcucuag                                                   20


<210>  25539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25539
aauuaccaga gccuugauuc                                                   20


<210>  25540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25540
guggcauagc cacagaguug                                                   20


<210>  25541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25541
uuaugaucag gagagacucu                                                   20


<210>  25542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25542
auuuggcaug cagaucacgu                                                   20


<210>  25543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25543
ccugccugcu uggagcaaag                                                   20


<210>  25544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25544
uuaacuaccc ccuacaccac                                                   20


<210>  25545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25545
cuccccucaa aagagaagau                                                   20


<210>  25546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25546
cuuuugaggg gagagaaggg                                                   20


<210>  25547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25547
ucaaggagcc aauggcgcca                                                   20


<210>  25548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25548
caguggggaa gcccuuugca                                                   20


<210>  25549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25549
ccacugggaa gacacacaca                                                   20


<210>  25550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25550
uggaucccca ucgagagugc                                                   20


<210>  25551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25551
cagccuugcc uugggcuccc                                                   20


<210>  25552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25552
caccaaccuc ugucucccgu                                                   20


<210>  25553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25553
caauuaauuc ucaccaaccu                                                   20


<210>  25554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25554
uuugugccuc ucaaugcacu                                                   20


<210>  25555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25555
aaaauagcuc uuaggauaug                                                   20


<210>  25556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25556
gagcagcccc auuuugcucc                                                   20


<210>  25557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25557
cuucccucca gggcgggggu                                                   20


<210>  25558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25558
cuccagggcg ggggugagca                                                   20


<210>  25559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25559
aaaggcugcu gaugggaggg                                                   20


<210>  25560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25560
gcugcccucc caucagcagc                                                   20


<210>  25561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25561
ugagagaagg uccccagacu                                                   20


<210>  25562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25562
cucaagaacg uggggucagc                                                   20


<210>  25563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25563
cggcauaauu uccuucucac                                                   20


<210>  25564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25564
uucucacuuc acuguucucu                                                   20


<210>  25565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25565
cacuucacug uucucuuccc                                                   20


<210>  25566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25566
cuguucucuu cccugucuga                                                   20


<210>  25567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25567
cuucccuguc ugaaauggca                                                   20


<210>  25568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25568
cugucugaaa uggcagguga                                                   20


<210>  25569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25569
gacagggaag agaacaguga                                                   20


<210>  25570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25570
cacaccauuc cuccucagca                                                   20


<210>  25571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25571
uccucagcac accugccaug                                                   20


<210>  25572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25572
ugcgucccuc uccaucugac                                                   20


<210>  25573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25573
cacuucaugc gucccucucc                                                   20


<210>  25574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25574
ucucacuuca ugcgucccuc                                                   20


<210>  25575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25575
uuaggccgcc gccaccuccg                                                   20


<210>  25576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25576
caguaagacu uucucaauga                                                   20


<210>  25577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25577
caaugaagga agcagugcau                                                   20


<210>  25578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25578
uugagaaagu cuuacuguga                                                   20


<210>  25579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25579
uucauugaga aagucuuacu                                                   20


<210>  25580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25580
ggugcaagca cucccggacu                                                   20


<210>  25581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25581
cugacuccuu gccucucucu                                                   20


<210>  25582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25582
gucaucacau cuguuucucu                                                   20


<210>  25583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25583
gagagucaga gagagguaug                                                   20


<210>  25584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25584
uaccucucuc ugacucucug                                                   20


<210>  25585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25585
caucuucaua ccucucucug                                                   20


<210>  25586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25586
uuucagaaga aaaaaauaaa                                                   20


<210>  25587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25587
gaagaaaaaa auaaauuuuu                                                   20


<210>  25588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25588
gaaaagaaaa uaaaacuuuu                                                   20


<210>  25589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25589
ucugaaaaga aaauaaaacu                                                   20


<210>  25590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25590
uugaccuaaa aauuuauuuu                                                   20


<210>  25591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25591
accauaaaau ccuaauauau                                                   20


<210>  25592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25592
cuuuauacca augcagcugu                                                   20


<210>  25593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25593
guaaauccuu caaaaaccgg                                                   20


<210>  25594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25594
aaaaccggca uuuuuaaaca                                                   20


<210>  25595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25595
guuuaaaaau gccgguuuuu                                                   20


<210>  25596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25596
uuugccaaag uacauccaag                                                   20


<210>  25597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25597
uauuuauaac ugaggauucc                                                   20


<210>  25598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25598
uuuucuuuga aaagcucccu                                                   20


<210>  25599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25599
uugaaaagcu cccuggaaga                                                   20


<210>  25600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25600
aagaaaagga auccucaguu                                                   20


<210>  25601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25601
agggagcuuu ucaaagaaaa                                                   20


<210>  25602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25602
ggaugacuug gaagcuaaau                                                   20


<210>  25603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25603
aagucaucca gaaaucuucc                                                   20


<210>  25604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25604
guggcucaag agcagacaaa                                                   20


<210>  25605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25605
uccacaggca gagaaccaaa                                                   20


<210>  25606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25606
acaggcagag aaccaaagug                                                   20


<210>  25607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25607
cugccugugg aagaaucuug                                                   20


<210>  25608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25608
ucucagcaaa cucuuugacu                                                   20


<210>  25609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25609
gacacauucc ucugccaaca                                                   20


<210>  25610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25610
ucugccaaca gcaaauaagu                                                   20


<210>  25611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25611
cacuuauuug cuguuggcag                                                   20


<210>  25612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25612
aaugagcagu ggcaucucuu                                                   20


<210>  25613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25613
cauuuguaaa agggaguguc                                                   20


<210>  25614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25614
gucugacacu cccuuuuaca                                                   20


<210>  25615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25615
ugcuuuuugg guuaaaacag                                                   20


<210>  25616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25616
ggccaacugc agccaagugg                                                   20


<210>  25617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25617
uagcuaugca uaggagacug                                                   20


<210>  25618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25618
ggguuuguga cuuuuaaguu                                                   20


<210>  25619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25619
ucuuuaaaca uuugcaagag                                                   20


<210>  25620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25620
ucaugaacac uucaauucua                                                   20


<210>  25621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25621
ugaugaaugu gaucugcagg                                                   20


<210>  25622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25622
auucuaucag accuucaugg                                                   20


<210>  25623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25623
aucagaccuu cauggcccuu                                                   20


<210>  25624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25624
uacacgcaug cuucuuggca                                                   20


<210>  25625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25625
uggcauaaaa uaggguuaca                                                   20


<210>  25626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25626
auagguuagg uauauuagac                                                   20


<210>  25627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25627
cuggugugaa gcagcaguug                                                   20


<210>  25628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25628
caccagugaa augagucagc                                                   20


<210>  25629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25629
uccugcuugg aaugcccuuu                                                   20


<210>  25630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25630
aagcaggagg aacagcuggu                                                   20


<210>  25631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25631
ucaggaccuc acuuggcucc                                                   20


<210>  25632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25632
acagagguga cacuccagaa                                                   20


<210>  25633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25633
aagaucuuac auuccacaga                                                   20


<210>  25634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25634
uugcuauucu ccagaaguaa                                                   20


<210>  25635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25635
ccagaaguaa gaaaguguuc                                                   20


<210>  25636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25636
ggagaauagc aaugaaccag                                                   20


<210>  25637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25637
uacuucugga gaauagcaau                                                   20


<210>  25638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25638
ugcagggagu aggagcauaa                                                   20


<210>  25639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25639
caucgaagaa aaacccagga                                                   20


<210>  25640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25640
augggaagcu uccaucuggu                                                   20


<210>  25641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25641
ucgaugggaa gcuuccaucu                                                   20


<210>  25642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25642
cugcugaguu cuacaaaaca                                                   20


<210>  25643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25643
acaaaacauu uaaagaacua                                                   20


<210>  25644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25644
uuaaauguuu uguagaacuc                                                   20


<210>  25645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25645
gaaaaauuga agagaaggga                                                   20


<210>  25646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25646
gaagaguuug aguaaaauug                                                   20


<210>  25647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25647
cuugccuaau ugcucuggcc                                                   20


<210>  25648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25648
uuuuuucucu ugccuaauug                                                   20


<210>  25649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25649
aauuuggaug cccuuucuuu                                                   20


<210>  25650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25650
uuccaauuug gaugcccuuu                                                   20


<210>  25651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25651
uucuuuccaa uuuggaugcc                                                   20


<210>  25652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25652
cagacaacac gaucuuauac                                                   20


<210>  25653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25653
aaguauaaga ucguguuguc                                                   20


<210>  25654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25654
aacaauuuuu ugguggaguc                                                   20


<210>  25655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25655
guaaaguugc aggauauaaa                                                   20


<210>  25656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25656
ucucauuuug uaauuggauu                                                   20


<210>  25657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25657
ucuucucauu uuguaauugg                                                   20


<210>  25658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25658
caaaauaaua uauacaaaug                                                   20


<210>  25659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25659
uauaucuguu ggccauuugu                                                   20


<210>  25660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25660
cugauuauga ugaugaguga                                                   20


<210>  25661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25661
cugucuuuuu gauaaaagcc                                                   20


<210>  25662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25662
gucaaugccu acacuucuga                                                   20


<210>  25663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25663
gaauggugcc cgcaccugau                                                   20


<210>  25664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25664
gaaguguagg cauugacuga                                                   20


<210>  25665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25665
ccaaagggug gccuagccau                                                   20


<210>  25666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25666
ucuacucccc uguaaugcca                                                   20


<210>  25667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25667
caaacaacuc aaggcaaaag                                                   20


<210>  25668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25668
cucuccauaa uggugcuuuu                                                   20


<210>  25669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25669
gaaugucaca gcagaaauau                                                   20


<210>  25670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25670
gaaguuugca guugaacaau                                                   20


<210>  25671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25671
gcugugacau ucugaaguuu                                                   20


<210>  25672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25672
aacauuucag acaaggcuau                                                   20


<210>  25673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25673
gacaaggcua ugagaucauc                                                   20


<210>  25674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25674
ucaaaaugca auuugcaaau                                                   20


<210>  25675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25675
aaaugcaauu ugcaaauaaa                                                   20


<210>  25676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25676
cccccgcccc aaccaucugc                                                   20


<210>  25677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25677
caaaauagag uaggagcuca                                                   20


<210>  25678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25678
uaaagaacca ggucucugag                                                   20


<210>  25679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25679
uuacgaaaag aggguuccca                                                   20


<210>  25680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25680
aaaauaagac aauuuccuua                                                   20


<210>  25681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25681
uuaacuaugc aaaugaauuc                                                   20


<210>  25682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25682
uuugcauagu uaaggaaauu                                                   20


<210>  25683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25683
uauuaauaau uccaugaaau                                                   20


<210>  25684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25684
augaaaugug ucuauaguaa                                                   20


<210>  25685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25685
uggaauuauu aauaugaauu                                                   20


<210>  25686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25686
cauucccuca ucacuugcuc                                                   20


<210>  25687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25687
cucaucacuu gcucugaaau                                                   20


<210>  25688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25688
gagcaaguga ugagggaaug                                                   20


<210>  25689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25689
gauaaauuuc agagcaagug                                                   20


<210>  25690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25690
ggaugccucc aagaaggucu                                                   20


<210>  25691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25691
uggaggcauc cagaaguuug                                                   20


<210>  25692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25692
uugaaagaaa aacaaguuca                                                   20


<210>  25693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25693
aagaacaaug auccuuaggu                                                   20


<210>  25694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25694
uucaaagaac aaugauccuu                                                   20


<210>  25695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25695
uuaaucuugc agacagcccc                                                   20


<210>  25696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25696
cuaaucauug auuaacuuua                                                   20


<210>  25697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25697
ccaugcauga uuacuugcac                                                   20


<210>  25698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25698
uucuccaugc augauuacuu                                                   20


<210>  25699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25699
cuuuguccuu uucuuucucc                                                   20


<210>  25700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25700
uuucucuuug uccuuuucuu                                                   20


<210>  25701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25701
guaaccaagc cugugugaua                                                   20


<210>  25702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25702
uccuguguuu cuguaaccaa                                                   20


<210>  25703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25703
uccuccugug uuucuguaac                                                   20


<210>  25704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25704
gauucuuccu ccuguguuuc                                                   20


<210>  25705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25705
uuucaagucc uaaccuccag                                                   20


<210>  25706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25706
aguccuaacc uccagaaccu                                                   20


<210>  25707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25707
ggagguuagg acuugaaaug                                                   20


<210>  25708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25708
gagguucugg agguuaggac                                                   20


<210>  25709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25709
aaauaagguc acauucugag                                                   20


<210>  25710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25710
uauuaaauaa uuacaucuac                                                   20


<210>  25711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25711
aacucucugc uaguuucugg                                                   20


<210>  25712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25712
cagaaggaac cagcccugcu                                                   20


<210>  25713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25713
gagaaaaaaa aaaaucucuu                                                   20


<210>  25714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25714
uucugagaaa aaaaaaaauc                                                   20


<210>  25715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25715
agccuccaga gcugugagac                                                   20


<210>  25716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25716
uagcgcugcc auaacaaagg                                                   20


<210>  25717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25717
uuuccuagcg cugccauaac                                                   20


<210>  25718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25718
ccuccucauc uuagagcagu                                                   20


<210>  25719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25719
acagugcaca gaacagucuc                                                   20


<210>  25720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25720
gugcacugua gaauguuuug                                                   20


<210>  25721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25721
uuguuguaag agacuguucu                                                   20


<210>  25722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25722
cauuuugagu cugauaauuc                                                   20


<210>  25723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25723
aacuauucac auuuugaguc                                                   20


<210>  25724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25724
ucagucuuca aacuauucac                                                   20


<210>  25725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25725
guaccucuaa aagaggguuc                                                   20


<210>  25726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25726
auuucuguac cucuaaaaga                                                   20


<210>  25727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25727
caaaaucucu aagaaaauua                                                   20


<210>  25728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25728
uagagauuuu gugaauugcu                                                   20


<210>  25729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25729
ugagaucaug cuccuauaca                                                   20


<210>  25730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25730
aguuuuccuu gcuauucccu                                                   20


<210>  25731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25731
uugcuauucc cugaaaaucu                                                   20


<210>  25732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25732
cugaaaaucu guugcuacuu                                                   20


<210>  25733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25733
gggaauagca aggaaaacug                                                   20


<210>  25734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25734
uccuaugcau ugcggauaug                                                   20


<210>  25735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25735
cuguaucuac cagccauggc                                                   20


<210>  25736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25736
cacuggguuu uuuuuuguug                                                   20


<210>  25737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25737
acaggaagga uuucaauagg                                                   20


<210>  25738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25738
uguggaauuu ggacuauucu                                                   20


<210>  25739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25739
auaggauaug gaugacaaag                                                   20


<210>  25740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25740
gagcacaggg ugcugugaga                                                   20


<210>  25741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25741
cuucugagca cagggugcug                                                   20


<210>  25742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25742
aaaugucagu aacuauuuuu                                                   20


<210>  25743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25743
uuuuuuuuaa uuugcuauau                                                   20


<210>  25744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25744
uuuuuuuugu uuucuuuuuu                                                   20


<210>  25745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25745
cccucucucu ugaccuauug                                                   20


<210>  25746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25746
uucucccucu cucuugaccu                                                   20


<210>  25747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25747
uccugcuuuu uaaacaaggg                                                   20


<210>  25748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25748
ugcuuuuuaa acaagggcuc                                                   20


<210>  25749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25749
gcuccuuuua ugccaguuag                                                   20


<210>  25750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25750
uucagcuccu uuuaugccag                                                   20


<210>  25751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25751
caguucuuuc agcuccuuuu                                                   20


<210>  25752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25752
gcuucucagu ucuuucagcu                                                   20


<210>  25753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25753
uggaguuucc aucaccauuu                                                   20


<210>  25754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25754
aucaccauuu auccaacuac                                                   20


<210>  25755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25755
ugauuucaga ucuuagagaa                                                   20


<210>  25756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25756
gaucuuagag aauaggaggg                                                   20


<210>  25757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25757
cuaagaucug aaaucaggaa                                                   20


<210>  25758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25758
ugugugucca cucagcccuc                                                   20


<210>  25759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25759
cugcccuccc uaaggcaggu                                                   20


<210>  25760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25760
ccgagagcau cucuucugag                                                   20


<210>  25761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25761
gagcagaguc cugagcgagg                                                   20


<210>  25762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25762
gaggaagaaa acggagcugu                                                   20


<210>  25763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25763
ucugaauggu ccucgcucag                                                   20


<210>  25764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25764
uccucugaau gguccucgcu                                                   20


<210>  25765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25765
aaggaggcag agaguacaug                                                   20


<210>  25766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25766
aaacuggcca uguacucucu                                                   20


<210>  25767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25767
aaguagcugg aguacaggga                                                   20


<210>  25768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25768
cuguacucca gcuacuugga                                                   20


<210>  25769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25769
cugagugcuc cucuucccug                                                   20


<210>  25770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25770
aucccaaauc cacacaagaa                                                   20


<210>  25771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25771
uguguggauu ugggauugaa                                                   20


<210>  25772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25772
gguccuuguu gcuucuugug                                                   20


<210>  25773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25773
aacugccacc uccuugguuc                                                   20


<210>  25774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25774
cuccauucca acugccaccu                                                   20


<210>  25775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25775
acgagcagug ugauggaccc                                                   20


<210>  25776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25776
ugggauaggc aguuuccuaa                                                   20


<210>  25777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25777
uaagauaguc cuccaugauc                                                   20


<210>  25778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25778
gcuauugaug uccuugugua                                                   20


<210>  25779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25779
agaggagggg auuacacaag                                                   20


<210>  25780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25780
uuggaggcaa gucacuaggu                                                   20


<210>  25781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25781
auucauugga ggcaagucac                                                   20


<210>  25782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25782
uccgagauua gguuauaaaa                                                   20


<210>  25783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25783
gagauuaggu uauaaaagau                                                   20


<210>  25784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25784
aaacacugug ccucaaagcu                                                   20


<210>  25785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25785
uugugacuau aacccuaucu                                                   20


<210>  25786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25786
cuuauuccuu gugacuauaa                                                   20


<210>  25787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25787
ucucuuauuc cuugugacua                                                   20


<210>  25788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25788
aguacauuug gagaacuucu                                                   20


<210>  25789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25789
ccaaauguac uugaaauuuu                                                   20


<210>  25790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25790
ggagcacuaa uuuauuuauc                                                   20


<210>  25791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25791
uuuucaguag agaugggguu                                                   20


<210>  25792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25792
guagagaugg gguuucacca                                                   20


<210>  25793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25793
ccauguuggc cacacugguc                                                   20


<210>  25794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25794
ggaccagugu ggccaacaug                                                   20


<210>  25795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25795
uaauaacuuc uacugaauua                                                   20


<210>  25796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25796
acugaauuag acuuuuauuu                                                   20


<210>  25797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25797
guagaaguua uuaggaaacc                                                   20


<210>  25798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25798
cuacuuacaa cacuuugaca                                                   20


<210>  25799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25799
agcuuaaugg agagacaguc                                                   20


<210>  25800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25800
aagaucuucu agcuuaaugg                                                   20


<210>  25801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25801
ugucuuccaa gaucuucuag                                                   20


<210>  25802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25802
acuuugcagc ccuaacacuu                                                   20


<210>  25803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25803
acaaacacuu ggucacuauu                                                   20


<210>  25804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25804
aguuguugaa uauucucaaa                                                   20


<210>  25805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25805
acaacuagaa ucucauucaa                                                   20


<210>  25806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25806
caaaaucucu aucaaacuuu                                                   20


<210>  25807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25807
acucccaaga ggaauuugga                                                   20


<210>  25808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25808
ucuugggagu agaacuagau                                                   20


<210>  25809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25809
gguaaaccaa aacuagcaga                                                   20


<210>  25810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25810
gccucugcua guuuugguuu                                                   20


<210>  25811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25811
uauuaaucuu ucugccucug                                                   20


<210>  25812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25812
ccagcgcuau uuuuugacau                                                   20


<210>  25813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25813
uucauuauuu gccaugguau                                                   20


<210>  25814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25814
uuauuugcca ugguauaaau                                                   20


<210>  25815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25815
cacgucucau guuuuaaaca                                                   20


<210>  25816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25816
gaaagaauuu gaaaguguga                                                   20


<210>  25817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25817
gaaaugucua aguauucuca                                                   20


<210>  25818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25818
uucugaaaug ucuaaguauu                                                   20


<210>  25819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25819
aauucuuucu gaaaugucua                                                   20


<210>  25820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25820
ccuaacuucu acagaaauuc                                                   20


<210>  25821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25821
acagaaauuc cacagauuca                                                   20


<210>  25822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25822
guagaaguua ggagaagcau                                                   20


<210>  25823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25823
acagauucau gaauucauuu                                                   20


<210>  25824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25824
ugaauucauu uauuuagcaa                                                   20


<210>  25825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25825
ugaaucugug gaauuucugu                                                   20


<210>  25826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25826
uuuauuuagc aaaugacucc                                                   20


<210>  25827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25827
uacgggaccu uggacacauu                                                   20


<210>  25828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25828
cauuuagacc cggggcagag                                                   20


<210>  25829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25829
aacccagcuc ugccccgggu                                                   20


<210>  25830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25830
gcuuuucaau gaauaaguua                                                   20


<210>  25831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25831
augaauaagu uauuuuuauc                                                   20


<210>  25832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25832
uugaaaagcg gaacugagau                                                   20


<210>  25833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25833
ccauuagugc uugacacauu                                                   20


<210>  25834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25834
uuuguauuuc cccauuagug                                                   20


<210>  25835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25835
aggaaucucc agucuggcug                                                   20


<210>  25836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25836
uagaaaguug auuuaauguc                                                   20


<210>  25837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25837
agccucugcu cagguaacua                                                   20


<210>  25838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25838
ugguugguca ggauaagaua                                                   20


<210>  25839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25839
uuagcaugaa aauuuuccca                                                   20


<210>  25840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25840
ugcuaaugaa auacguucau                                                   20


<210>  25841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25841
caaugcuuuu gagauucagc                                                   20


<210>  25842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25842
gccagcacac ccuguccuaa                                                   20


<210>  25843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25843
guguuaggac agggugugcu                                                   20


<210>  25844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25844
uggccucaau accuguggaa                                                   20


<210>  25845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25845
acagguauug aggccaggaa                                                   20


<210>  25846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25846
cuuuucauuu agcuuacauu                                                   20


<210>  25847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25847
uuuagcuuac auuugcugcc                                                   20


<210>  25848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25848
uccccuucau uccuggacuc                                                   20


<210>  25849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25849
ccuucauucc uggacucucu                                                   20


<210>  25850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25850
uuccuggacu cucuccuuuc                                                   20


<210>  25851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25851
uggacucucu ccuuucuucu                                                   20


<210>  25852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25852
ucucaaacaa ggggcccacu                                                   20


<210>  25853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25853
caaacaaggg gcccacuucg                                                   20


<210>  25854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25854
gucuugacca agcccuucau                                                   20


<210>  25855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25855
ucuuccugaa uuucucagcu                                                   20


<210>  25856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25856
ugaauuucuc agcuaaaucg                                                   20


<210>  25857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25857
ggaagaugaa gggcuugguc                                                   20


<210>  25858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25858
cagcuaaauc guuucuaacg                                                   20


<210>  25859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25859
aacgcuuccc uuuuuccaac                                                   20


<210>  25860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25860
cuuuuuccaa cauaaauagu                                                   20


<210>  25861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25861
aacauaaaua guucuuucuc                                                   20


<210>  25862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25862
uucucgcuca uugucccacc                                                   20


<210>  25863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25863
cgcucauugu cccacccugc                                                   20


<210>  25864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25864
uuuuuaagaa ucucuguagc                                                   20


<210>  25865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25865
uaaaaaggaa aaauaaauau                                                   20


<210>  25866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25866
gaaaugaggc aacgcagcuc                                                   20


<210>  25867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25867
gaagaguaga ggcuacagag                                                   20


<210>  25868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25868
gugaccauaa uaaagggcuu                                                   20


<210>  25869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25869
uggagauccu ucccucauuu                                                   20


<210>  25870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25870
cucauuuauc ugucaucuca                                                   20


<210>  25871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25871
aggucacauc auuuccuagc                                                   20


<210>  25872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25872
uagcaucuaa aguguugucu                                                   20


<210>  25873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25873
acuccuccau ugcuuuaaaa                                                   20


<210>  25874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25874
agcaccacga ggcacucacu                                                   20


<210>  25875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25875
acauuccagc accacgaggc                                                   20


<210>  25876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25876
aauuucaaug aagggcaugc                                                   20


<210>  25877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25877
augaagggca ugcugccauu                                                   20


<210>  25878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25878
uugaaauuag aagagacuuu                                                   20


<210>  25879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25879
agagaaggaa gaggaacaaa                                                   20


<210>  25880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25880
cuggaaaaug gcagcaugcc                                                   20


<210>  25881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25881
uucucuggaa aauggcagca                                                   20


<210>  25882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25882
ucuuccuucu cuggaaaaug                                                   20


<210>  25883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25883
aagaaccugu ugauguuaau                                                   20


<210>  25884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25884
uugaaaacaa ggcuauaugu                                                   20


<210>  25885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25885
uugagacagc uaacaguaac                                                   20


<210>  25886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25886
ggaaacacag acagcccuca                                                   20


<210>  25887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25887
ggaagauucc agggaauacu                                                   20


<210>  25888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25888
ugaggcccca aaucccugag                                                   20


<210>  25889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25889
uguuaugugu ugaauugugu                                                   20


<210>  25890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25890
acacauaaca ugaaccaagu                                                   20


<210>  25891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25891
gagguacuag ggguuaagac                                                   20


<210>  25892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25892
uagggcuacu gugacaaagu                                                   20


<210>  25893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25893
uuuagcaaaa agucuugguu                                                   20


<210>  25894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25894
agugucccuc caggugcugu                                                   20


<210>  25895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25895
aaagagggca uggaacugca                                                   20


<210>  25896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25896
augcccucuu uugaagaccc                                                   20


<210>  25897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25897
ccugcaguuc caugcccucu                                                   20


<210>  25898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25898
cuuauuuagc acaaacucua                                                   20


<210>  25899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25899
uucauucaac aaauauuugu                                                   20


<210>  25900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25900
uucaacaaau auuuguuaag                                                   20


<210>  25901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25901
acaaauauuu guuaagcccc                                                   20


<210>  25902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25902
gggguucuag cagugagcag                                                   20


<210>  25903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25903
acaguauaua uccauaucuc                                                   20


<210>  25904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25904
ugauccccca caaaugggau                                                   20


<210>  25905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25905
cagagaccua aagugcaaua                                                   20


<210>  25906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25906
uuguuuuaag ccaccuaguu                                                   20


<210>  25907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25907
ggagaccaga aggcugaaau                                                   20


<210>  25908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25908
ggucuccaga acugugagag                                                   20


<210>  25909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25909
gccuucuggu cuccagaacu                                                   20


<210>  25910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25910
uucuugggcc ucaaaaggag                                                   20


<210>  25911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25911
ugggccucaa aaggagaguc                                                   20


<210>  25912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25912
uagguauaag cugguuccca                                                   20


<210>  25913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25913
uuccuaggua uaagcugguu                                                   20


<210>  25914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25914
gcaugagaag uaaucccacc                                                   20


<210>  25915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25915
caugccgaau caaaguuuua                                                   20


<210>  25916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25916
cuaggucauu cucuggauuc                                                   20


<210>  25917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25917
uuuucuagac ugguugaguc                                                   20


<210>  25918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25918
agacugguug aguccaacaa                                                   20


<210>  25919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25919
guagaguugg cuaaucugcu                                                   20


<210>  25920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25920
caagggagaa aggaaagagu                                                   20


<210>  25921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25921
cccuugugaa uaucacuauu                                                   20


<210>  25922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25922
uuucucccuu gugaauauca                                                   20


<210>  25923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25923
aauaaauauu uuaagauaga                                                   20


<210>  25924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25924
aucuuaaaau auuuauuuga                                                   20


<210>  25925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25925
cgggauuuaa uuucuaucuu                                                   20


<210>  25926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25926
gaugauucac gggauuuaau                                                   20


<210>  25927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25927
uauuugugau uuucugauga                                                   20


<210>  25928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25928
cuuuuauuau auuuuggggu                                                   20


<210>  25929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25929
cacguuuuga acucauauuc                                                   20


<210>  25930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25930
aaacguggga accuuccuga                                                   20


<210>  25931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25931
uauccuuuga uucauugaau                                                   20


<210>  25932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25932
uugaauuuuu ggccauucuc                                                   20


<210>  25933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25933
augaaucaaa ggauaggaau                                                   20


<210>  25934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25934
cgcauuaggu caaaaaaaaa                                                   20


<210>  25935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25935
uggggaauag ccaacuucuu                                                   20


<210>  25936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25936
ccaugaaacu cugagcaacu                                                   20


<210>  25937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25937
uuuccaagac cugccuugua                                                   20


<210>  25938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25938
aagaccugcc uuguacuucc                                                   20


<210>  25939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25939
ugcuucucuc acugggggca                                                   20


<210>  25940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25940
cucacugggg gcaaauaaaa                                                   20


<210>  25941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25941
cugggauaau uugucuccua                                                   20


<210>  25942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25942
uagaacagag uaaaaauuau                                                   20


<210>  25943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25943
aggaagcuuu cucugggaua                                                   20


<210>  25944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25944
auaauuuuua cucuguucua                                                   20


<210>  25945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25945
gccacuuguu aucauuuuuc                                                   20


<210>  25946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25946
gagaaauaaa ugugauuuau                                                   20


<210>  25947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25947
cugaacauuu cagccacuug                                                   20


<210>  25948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25948
cgucugugcu uaugugcucu                                                   20


<210>  25949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25949
cuucacaucu ggugaccuuu                                                   20


<210>  25950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25950
caucugguga ccuuuggaac                                                   20


<210>  25951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25951
aaaggucacc agaugugaag                                                   20


<210>  25952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25952
gaaaaacuuc caccacacac                                                   20


<210>  25953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25953
gaaaguucca aaggucacca                                                   20


<210>  25954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25954
accacacaca aacaccuaag                                                   20


<210>  25955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25955
uagauguacc uuuuaauuuu                                                   20


<210>  25956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25956
uuguuuugua uuuuagucca                                                   20


<210>  25957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25957
uaagaacuua aucaaaaacu                                                   20


<210>  25958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25958
uaagaaaugc cucucaagau                                                   20


<210>  25959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25959
guauccaaua uuguaaaguc                                                   20


<210>  25960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25960
aaggaugaag augugaaagg                                                   20


<210>  25961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25961
uccuuggaaa cucaaauuga                                                   20


<210>  25962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25962
caucuucauc cuuggaaacu                                                   20


<210>  25963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25963
uucucaacau auuugcuaaa                                                   20


<210>  25964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25964
caacauauuu gcuaaagaaa                                                   20


<210>  25965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25965
uuagcaaaua uguugagaag                                                   20


<210>  25966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25966
uccucuuucu uuagcaaaua                                                   20


<210>  25967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25967
uuucauccuc uuucuuuagc                                                   20


<210>  25968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25968
uuguuaucag ccaguuaguu                                                   20


<210>  25969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25969
gucuucgcag cauuuucucc                                                   20


<210>  25970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25970
cagcauuuuc uccucauaua                                                   20


<210>  25971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25971
ccucauauac cugauuuucu                                                   20


<210>  25972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25972
caccauucug uuacagaaua                                                   20


<210>  25973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25973
guuacagaau augagacaag                                                   20


<210>  25974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25974
guaacagaau ggugagaaaa                                                   20


<210>  25975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25975
aauaagagcc ugcugcucuu                                                   20


<210>  25976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25976
auaccaaaga gcagcaggcu                                                   20


<210>  25977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25977
uugagguuuu uguuuuguuu                                                   20


<210>  25978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25978
uggcugcuaa acuuaaaaaa                                                   20


<210>  25979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25979
agaguuaagg cugauaaaac                                                   20


<210>  25980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25980
cccacacuug ggcaggugag                                                   20


<210>  25981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25981
ggacucaugu uuucucccac                                                   20


<210>  25982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25982
caaaauagaa agauuuuucu                                                   20


<210>  25983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25983
auuuugagaa aggcaauuua                                                   20


<210>  25984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25984
gguuuuauuu ggccugggaa                                                   20


<210>  25985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25985
caggccaaau aaaaccagaa                                                   20


<210>  25986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25986
gcuuuguucc caggccaaau                                                   20


<210>  25987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25987
cccucuaaca ucugcuucuu                                                   20


<210>  25988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25988
uggaucucug ggaggcucag                                                   20


<210>  25989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25989
gagccuccca gagauccaag                                                   20


<210>  25990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25990
caguuucuga gccucccaga                                                   20


<210>  25991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25991
uccauaaagg ugcuuagggg                                                   20


<210>  25992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25992
agaaauuaau cggagucuua                                                   20


<210>  25993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25993
uuaacugugu uggucaguca                                                   20


<210>  25994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25994
cuguuccuuu ucguacacau                                                   20


<210>  25995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25995
uuuucguaca caucuuccaa                                                   20


<210>  25996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25996
uacacaucuu ccaaacccac                                                   20


<210>  25997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25997
aaacccacca ucuucccaaa                                                   20


<210>  25998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25998
caaaccaggc cuauuaacca                                                   20


<210>  25999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  25999
gguuaauagg ccugguuugg                                                   20


<210>  26000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26000
gaaacauugu uuguuuaaau                                                   20


<210>  26001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26001
gaauugauuu cugguuaaua                                                   20


<210>  26002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26002
ccaguugggc uuuuggucca                                                   20


<210>  26003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26003
caaggucauu guuacucaga                                                   20


<210>  26004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26004
auuggugaau uuuugcuguu                                                   20


<210>  26005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26005
ccaauggaac augugcaaaa                                                   20


<210>  26006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26006
uuuuuuuuuu uuuuaaaugg                                                   20


<210>  26007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26007
cauuuaaaaa aaaaaaaaaa                                                   20


<210>  26008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26008
uaugcugcug uucaaucgga                                                   20


<210>  26009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26009
aucggagucu gaaagcugaa                                                   20


<210>  26010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26010
gacuccgauu gaacagcagc                                                   20


<210>  26011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26011
gcuuucagac uccgauugaa                                                   20


<210>  26012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26012
auuacagcac aaccuugugg                                                   20


<210>  26013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26013
aauagcccgg cuucugccuc                                                   20


<210>  26014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26014
gccucgcugu gagacagugg                                                   20


<210>  26015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26015
ucucuaaaau ggggauagcg                                                   20


<210>  26016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26016
uauaaagauu aaaagcagug                                                   20


<210>  26017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26017
uuagacauca gggagccagg                                                   20


<210>  26018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26018
gagcagccca guacaggacu                                                   20


<210>  26019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26019
aaaucuguuu guguuuuaag                                                   20


<210>  26020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26020
cugucuucaa aaucuguuug                                                   20


<210>  26021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26021
caaguuucuc ugucuucaaa                                                   20


<210>  26022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26022
auuggcuuaa aaauccaaau                                                   20


<210>  26023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26023
auuuaaaucu ccaaccugau                                                   20


<210>  26024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26024
cuaccaaguu ccagagcaac                                                   20


<210>  26025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26025
agagcaacac ucaauuuaug                                                   20


<210>  26026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26026
auauguccca ccaggguaca                                                   20


<210>  26027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26027
ucuuucuaua ugucccacca                                                   20


<210>  26028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26028
guucaucuuu cuauaugucc                                                   20


<210>  26029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26029
gacuggcucc aacucuuuca                                                   20


<210>  26030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26030
aguccacauc caauccaccu                                                   20


<210>  26031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26031
gguuucuucc uacuucuuua                                                   20


<210>  26032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26032
cuagaagcca aagcaagaga                                                   20


<210>  26033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26033
agagaauuau ccucuucugg                                                   20


<210>  26034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26034
agaaagcauu caucaucauc                                                   20


<210>  26035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26035
ugaagcacuc ucuugcuuug                                                   20


<210>  26036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26036
ucaucaucag ugucaaaaau                                                   20


<210>  26037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26037
cuccccuugg auuuuugaca                                                   20


<210>  26038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26038
uucuggacua auaaaaaugu                                                   20


<210>  26039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26039
ggacuaauaa aaauguucua                                                   20


<210>  26040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26040
aaaauugauu guggugauua                                                   20


<210>  26041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26041
ggauauuaau caccacaauc                                                   20


<210>  26042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26042
guauauauuc uggauauuaa                                                   20


<210>  26043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26043
uacaaaugaa caacaacaaa                                                   20


<210>  26044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26044
aaagaagaua uacaaauggc                                                   20


<210>  26045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26045
uuggaaaaau aauucaaguc                                                   20


<210>  26046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26046
ugugcuuauu ggccauuugu                                                   20


<210>  26047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26047
aaugacuagu gguguugagu                                                   20


<210>  26048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26048
acugugugug ugugugugug                                                   20


<210>  26049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26049
gccuuaaaaa cgaaggaaau                                                   20


<210>  26050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26050
uuuuuaaggc ugaauaauau                                                   20


<210>  26051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26051
uucguuuuua aggcugaaua                                                   20


<210>  26052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26052
gacacaugcu auaacaugga                                                   20


<210>  26053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26053
uuccucucca gccccuggca                                                   20


<210>  26054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26054
acuuugcaaa augaaaagag                                                   20


<210>  26055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26055
uuuugcaaag uugaaacucu                                                   20


<210>  26056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26056
ggagauugau ggugggaaug                                                   20


<210>  26057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26057
caccaucaau cuccagaaaa                                                   20


<210>  26058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26058
auggcauuaa guacacucac                                                   20


<210>  26059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26059
uggcuaaggc caggugcaau                                                   20


<210>  26060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26060
auuuccuuca auuauugccu                                                   20


<210>  26061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26061
cagaguugua cacccauccc                                                   20


<210>  26062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26062
cauuuuaaaa uauucacaga                                                   20


<210>  26063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26063
guuuaaaugg guguauugca                                                   20


<210>  26064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26064
cauacuaugc aauacaccca                                                   20


<210>  26065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26065
aagaaaacuc agggauaguc                                                   20


<210>  26066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26066
uugaaaugga uuuauugaga                                                   20


<210>  26067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26067
guggagugau gcagaaggaa                                                   20


<210>  26068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26068
acuuugccaa ggaucaaauc                                                   20


<210>  26069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26069
cacucucaau cuucaacuuu                                                   20


<210>  26070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26070
uucucacucu caaucuucaa                                                   20


<210>  26071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26071
ccuuguguua ccaucuuccu                                                   20


<210>  26072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26072
acagauuucc ccuuguguua                                                   20


<210>  26073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26073
cagcuuucca cagauuuccc                                                   20


<210>  26074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26074
uaaaucccau guuauuaauu                                                   20


<210>  26075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26075
aggaggcuac ucuuuaguca                                                   20


<210>  26076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26076
ggcaaaacaa uuccuucuuu                                                   20


<210>  26077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26077
cuuucauuca ucacucacuc                                                   20


<210>  26078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26078
uucaucacuc acucagugac                                                   20


<210>  26079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26079
ucacucacuc agugacuuac                                                   20


<210>  26080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26080
ugguaagugc ccuauagagc                                                   20


<210>  26081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26081
auguuuagau guguuuagau                                                   20


<210>  26082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26082
guaugaucac augcuauaca                                                   20


<210>  26083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26083
cauuauccgc aacauaaacu                                                   20


<210>  26084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26084
cuuuccuccu ucuccccagc                                                   20


<210>  26085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26085
uccuucuccc cagccccugg                                                   20


<210>  26086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26086
ccccagcccc ugguaaccuc                                                   20


<210>  26087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26087
cagacacaga aaguggaaua                                                   20


<210>  26088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26088
aggaaucuca cauaaguaga                                                   20


<210>  26089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26089
uagaauaggc aaauucacag                                                   20


<210>  26090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26090
acuuauguga gauuccuaga                                                   20


<210>  26091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26091
ucugugucug guuuauuuua                                                   20


<210>  26092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26092
gugucugguu uauuuuacug                                                   20


<210>  26093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26093
acagcggcug caccauuuua                                                   20


<210>  26094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26094
cacuggcaac acacaagguu                                                   20


<210>  26095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26095
aguuucucca cauucucacc                                                   20


<210>  26096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26096
ccacauucuc accaauacuu                                                   20


<210>  26097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26097
uuuuugaaaa aacauauuau                                                   20


<210>  26098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26098
aaaaagaaaa uaacaaguau                                                   20


<210>  26099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26099
uacuuacuag uauggcuaua                                                   20


<210>  26100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26100
uguguuuauu ggucauuugu                                                   20


<210>  26101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26101
uugaaaaacu gucuauucaa                                                   20


<210>  26102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26102
aagaagauaa uacaaaugac                                                   20


<210>  26103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26103
aguucuuuug cccauuuuug                                                   20


<210>  26104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26104
uuugcccauu uuugaauuga                                                   20


<210>  26105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26105
uagacaccuu uuuuuuuugu                                                   20


<210>  26106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26106
auauuuuaua uuuuuguauu                                                   20


<210>  26107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26107
caccaagcau gcagugacca                                                   20


<210>  26108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26108
auuaccacaa acaacuucca                                                   20


<210>  26109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26109
acguauaggu uuguguaacc                                                   20


<210>  26110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26110
gugcacuuuu guuccacgua                                                   20


<210>  26111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26111
gaauuucacu gacuguagcu                                                   20


<210>  26112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26112
ugauagucac acugugcuua                                                   20


<210>  26113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26113
guuuuuuuuu uuuagaugga                                                   20


<210>  26114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26114
uguccucuuu ucaguuuuuu                                                   20


<210>  26115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26115
guucuugucc ucuuuucagu                                                   20


<210>  26116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26116
uaccuuucug uucuuguccu                                                   20


<210>  26117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26117
gaacacuguc acaacuucau                                                   20


<210>  26118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26118
gaaaaaaaau gcagcuuaau                                                   20


<210>  26119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26119
uacuaaauau acuucuggau                                                   20


<210>  26120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26120
agaaaaucag cguuuuccau                                                   20


<210>  26121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26121
agaaauacaa auuguaauca                                                   20


<210>  26122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26122
auauccuauu aaauacaagc                                                   20


<210>  26123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26123
auuuguuuua uuaaagacau                                                   20


<210>  26124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26124
ucuuggcucu gucaccccac                                                   20


<210>  26125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26125
ccuuuuccca ccccucuauu                                                   20


<210>  26126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26126
caccccucua uuuuccuauu                                                   20


<210>  26127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26127
uauucaucgu gucauggaga                                                   20


<210>  26128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26128
ucgugucaug gagaaaugcu                                                   20


<210>  26129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26129
ccaugacacg augaauagga                                                   20


<210>  26130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26130
acccagcaug guuccggugg                                                   20


<210>  26131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26131
gguggagaua ugaaucacca                                                   20


<210>  26132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26132
uaucuccacc ggaaccaugc                                                   20


<210>  26133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26133
uguaguugcu gcugauggug                                                   20


<210>  26134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26134
uaaagggagu uacagaaaua                                                   20


<210>  26135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26135
guaacucccu uuaagaaaca                                                   20


<210>  26136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26136
auuucuguaa cucccuuuaa                                                   20


<210>  26137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26137
ggaugguugu gacauauucu                                                   20


<210>  26138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26138
gacuugauca acacuugaag                                                   20


<210>  26139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26139
aguguugauc aagucugaau                                                   20


<210>  26140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26140
cuucaagugu ugaucaaguc                                                   20


<210>  26141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26141
uucccuucaa guguugauca                                                   20


<210>  26142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26142
guggagacac uggaguaaau                                                   20


<210>  26143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26143
ucucugucag auggagagau                                                   20


<210>  26144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26144
ucucuccauc ugacagagag                                                   20


<210>  26145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26145
uccauuucca aagaagguaa                                                   20


<210>  26146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26146
auuuccaaag aagguaauua                                                   20


<210>  26147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26147
aaagaaggua auuauuauga                                                   20


<210>  26148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26148
uuggaaaugg aagaauuuca                                                   20


<210>  26149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26149
uaauaauuac cuucuuugga                                                   20


<210>  26150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26150
agacccagga ggugagacac                                                   20


<210>  26151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26151
gcggggagaa accucucacc                                                   20


<210>  26152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26152
ggcuuggugc uuuguuucuu                                                   20


<210>  26153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26153
ugggagccuu uaaugaaaac                                                   20


<210>  26154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26154
uuaaaggcuc ccaagaaaca                                                   20


<210>  26155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26155
uugggauuuu aacauaaaua                                                   20


<210>  26156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26156
uucugaauaa auuuaucaag                                                   20


<210>  26157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26157
gaauaaauuu aucaagcaau                                                   20


<210>  26158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26158
gaaggaaaau aaauuuauuu                                                   20


<210>  26159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26159
ccugccucag ccucccaagu                                                   20


<210>  26160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26160
ggugugagcc acugcaccug                                                   20


<210>  26161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26161
uaaagggaua agagagaaac                                                   20


<210>  26162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26162
cucuuauccc uuuaagaaua                                                   20


<210>  26163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26163
ggaaaggcuu aaguucaguu                                                   20


<210>  26164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26164
agaaagucuc aaaaguuucu                                                   20


<210>  26165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26165
guuccgccau uguaccuugg                                                   20


<210>  26166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26166
gccauuguac cuuggcuucu                                                   20


<210>  26167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26167
cuuugagaag ggagacuuaa                                                   20


<210>  26168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26168
caaagagaag ccaagguaca                                                   20


<210>  26169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26169
cauccccuga cauagcuguc                                                   20


<210>  26170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26170
aacuaaugag acagcuaugu                                                   20


<210>  26171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26171
auguuccaac uaaugagaca                                                   20


<210>  26172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26172
uuguaggcag aucuggccca                                                   20


<210>  26173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26173
uaucaccaau guccucaugc                                                   20


<210>  26174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26174
gaaugucauu cgugcacauu                                                   20


<210>  26175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26175
gaauugcauc uuuucuuauc                                                   20


<210>  26176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26176
ugcacauugu aguugaagac                                                   20


<210>  26177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26177
acuacaaugu gcacgaauga                                                   20


<210>  26178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26178
cuuuguuauu uaaguuacau                                                   20


<210>  26179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26179
uccuuccauc uucauuuuac                                                   20


<210>  26180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26180
uuccaucuuc auuuuacaac                                                   20


<210>  26181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26181
aucuucauuu uacaacagcu                                                   20


<210>  26182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26182
uuuuacaaca gcuccuuccc                                                   20


<210>  26183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26183
cuugaguaau ccaccucaca                                                   20


<210>  26184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26184
ugcuuuccuu agauggaggc                                                   20


<210>  26185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26185
gaaaggaccc aguccuggaa                                                   20


<210>  26186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26186
gaacacaacc aacagugcug                                                   20


<210>  26187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26187
aggacugggu ccuuucagaa                                                   20


<210>  26188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26188
auuccaggac uggguccuuu                                                   20


<210>  26189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26189
auagaagaag aaauuucaag                                                   20


<210>  26190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26190
auugaauaag uacaagugcu                                                   20


<210>  26191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26191
ucuauugaau aaguacaagu                                                   20


<210>  26192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26192
ucuucuauug aauaaguaca                                                   20


<210>  26193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26193
aggcuuaauu agugcagaug                                                   20


<210>  26194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26194
ucugcacuaa uuaagccuug                                                   20


<210>  26195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26195
ucaucugcac uaauuaagcc                                                   20


<210>  26196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26196
guuuuuaguc aaagcugaug                                                   20


<210>  26197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26197
uucauucaac aaauaugcau                                                   20


<210>  26198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26198
uucaacaaau augcauugag                                                   20


<210>  26199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26199
acaaauaugc auugagugcc                                                   20


<210>  26200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26200
caguauguaa cacaguaccu                                                   20


<210>  26201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26201
gugcuuauuc ucaguaugua                                                   20


<210>  26202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26202
uggucaacag cacguaucac                                                   20


<210>  26203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26203
uuuuuuuauc uugcuuguac                                                   20


<210>  26204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26204
aaagaaaaac gcucacugcc                                                   20


<210>  26205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26205
uuugaaaauu uaccuuuucc                                                   20


<210>  26206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26206
auuuuaaaau agccuucuga                                                   20


<210>  26207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26207
cuggucaguu gaaggucagg                                                   20


<210>  26208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26208
acugaccagu gaaaaagagu                                                   20


<210>  26209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26209
agccugaccu ucaacugacc                                                   20


<210>  26210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26210
gguugccuca uucugucuuu                                                   20


<210>  26211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26211
gucuuuuaaa ccaugacaga                                                   20


<210>  26212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26212
gucaugguuu aaaagacaga                                                   20


<210>  26213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26213
aucacccaug aguccuuacu                                                   20


<210>  26214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26214
cccugcagga ccuuggcaca                                                   20


<210>  26215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26215
ugucaagucu ugugugugcc                                                   20


<210>  26216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26216
cgugugaauc uuugugggga                                                   20


<210>  26217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26217
cacgugaagu cucaucucag                                                   20


<210>  26218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26218
uugcucccca caaagauuca                                                   20


<210>  26219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26219
agagaguuca cacuuugagc                                                   20


<210>  26220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26220
cacuuugagc aacauugugg                                                   20


<210>  26221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26221
ccacaauguu gcucaaagug                                                   20


<210>  26222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26222
cauggucacc agccagcccu                                                   20


<210>  26223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26223
augacaauua acaguaaagg                                                   20


<210>  26224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26224
uuuuaauaau aacauaauug                                                   20


<210>  26225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26225
ggugcacaga gacagggcag                                                   20


<210>  26226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26226
aauaaugccc ccguuuuuac                                                   20


<210>  26227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26227
aagugcuugg ggugugugug                                                   20


<210>  26228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26228
gccucucaga ugaucauggc                                                   20


<210>  26229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26229
uuauagcaau gugagaaugg                                                   20


<210>  26230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26230
cacauugcua uaaggaacua                                                   20


<210>  26231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26231
cccaaugcau uaguccauuc                                                   20


<210>  26232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26232
aaugaguuuc acccaaugca                                                   20


<210>  26233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26233
ugucucugcu cuugucuugc                                                   20


<210>  26234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26234
accaauaguc aguuuccugu                                                   20


<210>  26235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26235
uuccuuuaaa augaggcuau                                                   20


<210>  26236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26236
uuuaaaauga ggcuauuacc                                                   20


<210>  26237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26237
caaaacuggg guaauagccu                                                   20


<210>  26238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26238
guuauugucc cuuguaauuc                                                   20


<210>  26239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26239
uacaucuaua aucccuuuaa                                                   20


<210>  26240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26240
ccuuauuaag gguaagagua                                                   20


<210>  26241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26241
cagucuggaa uauuuguauu                                                   20


<210>  26242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26242
agacugagaa caucuccuuu                                                   20


<210>  26243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26243
gugcuaaagc cagaacagac                                                   20


<210>  26244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26244
ggcuuuagca cugaaaacac                                                   20


<210>  26245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26245
augucuguuc uggcuuuagc                                                   20


<210>  26246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26246
ccuguuccug uucaacucuc                                                   20


<210>  26247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26247
uguucaacuc ucuuaauucc                                                   20


<210>  26248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26248
acucucuuaa uuccauuagc                                                   20


<210>  26249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26249
uauuucuuac agaguguuaa                                                   20


<210>  26250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26250
uacagagugu uaauaaaccu                                                   20


<210>  26251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26251
uagguuuauu aacacucugu                                                   20


<210>  26252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26252
gcucccuugg uaccccuaau                                                   20


<210>  26253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26253
ucugcucccu ugguaccccu                                                   20


<210>  26254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26254
cuuucauucu guuucuccuc                                                   20


<210>  26255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26255
uucuguuucu ccucccagcc                                                   20


<210>  26256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26256
guuucuccuc ccagccuccu                                                   20


<210>  26257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26257
ccucccagcc uccuguuacc                                                   20


<210>  26258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26258
gaagaccugu gaguugaaca                                                   20


<210>  26259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26259
gaaagauggg uaacaggagg                                                   20


<210>  26260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26260
acucacaggu cuucugaaag                                                   20


<210>  26261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26261
guuggccagu guugagugug                                                   20


<210>  26262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26262
ccaaccacag auaugcaaga                                                   20


<210>  26263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26263
ugcauaucug ugguuggaga                                                   20


<210>  26264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26264
aagugucagu ggagagcaua                                                   20


<210>  26265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26265
acugagcaca aacuugggag                                                   20


<210>  26266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26266
ucagguaaau gccuugauua                                                   20


<210>  26267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26267
uucaucaggu aaaugccuug                                                   20


<210>  26268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26268
cccucuucau ucaucaggua                                                   20


<210>  26269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26269
ucccccucuu cauucaucag                                                   20


<210>  26270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26270
aauacaucua gcacauuccc                                                   20


<210>  26271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26271
cauuaagcca cggaacuugc                                                   20


<210>  26272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26272
guggcuuaau gggaaugugc                                                   20


<210>  26273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26273
cuugugcaag gcugcacuug                                                   20


<210>  26274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26274
ugaaauuauc aaaaaugaaa                                                   20


<210>  26275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26275
ugaaaaaaag cgcuguauug                                                   20


<210>  26276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26276
uuuuugauaa uuucaugaaa                                                   20


<210>  26277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26277
uuucauuuuu gauaauuuca                                                   20


<210>  26278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26278
aauucauuuc auuuuugaua                                                   20


<210>  26279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26279
uucaaauuca uuucauuuuu                                                   20


<210>  26280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26280
ccuaggauau ucuuucaaau                                                   20


<210>  26281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26281
acuacuuaac aagaagaggu                                                   20


<210>  26282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26282
uguuaaguag uugaaugucu                                                   20


<210>  26283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26283
caaaauaaua aacgaggguc                                                   20


<210>  26284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26284
ugccaauaau ucaguagcau                                                   20


<210>  26285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26285
guagcauuua cgucuccauu                                                   20


<210>  26286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26286
caggcaggag auuccauggc                                                   20


<210>  26287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26287
auggcuaaug gccagucccu                                                   20


<210>  26288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26288
aaugccaaac ucaagauaca                                                   20


<210>  26289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26289
cacugagccc agagucaagu                                                   20


<210>  26290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26290
gcacaggaga ucucuaacuu                                                   20


<210>  26291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26291
auuauucugc aauauagcag                                                   20


<210>  26292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26292
gcaauauagc agaguaaaau                                                   20


<210>  26293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26293
uuuaggcugu guguuuuuug                                                   20


<210>  26294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26294
gaccaugcug gcugcauauu                                                   20


<210>  26295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26295
gaaaagcuuu ugauaagcau                                                   20


<210>  26296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26296
gaauaugcag ccagcauggu                                                   20


<210>  26297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26297
uaucgaaaag gugcugcacc                                                   20


<210>  26298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26298
auaugaaaac gugccugugc                                                   20


<210>  26299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26299
aaaggugcag caccuuuucg                                                   20


<210>  26300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26300
uucaggggua cuuuauaagc                                                   20


<210>  26301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26301
gggguacuuu auaagcaaua                                                   20


<210>  26302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26302
agauucaaac auuagucccc                                                   20


<210>  26303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26303
aacauuaguc cccaguuuua                                                   20


<210>  26304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26304
ccuaaaacug gggacuaaug                                                   20


<210>  26305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26305
aaguguaccc cccagaaaga                                                   20


<210>  26306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26306
gggggguaca cuuugaaaua                                                   20


<210>  26307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26307
caaaacaggg aaagcucauu                                                   20


<210>  26308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26308
cuguuuugag aacagguauc                                                   20


<210>  26309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26309
caguuuaaag aaaacaaaga                                                   20


<210>  26310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26310
uuaaacugug aaaugagcuu                                                   20


<210>  26311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26311
uuguuuucuu uaaacuguga                                                   20


<210>  26312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26312
uuucuuuguu uucuuuaaac                                                   20


<210>  26313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26313
aggcuggagg gaaggucccu                                                   20


<210>  26314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26314
cuccagccuu gaagggagag                                                   20


<210>  26315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26315
cuugccagag ggaccuuccc                                                   20


<210>  26316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26316
acccacuggc ugaugcucaa                                                   20


<210>  26317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26317
acuauuagga cauaaucacu                                                   20


<210>  26318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26318
gcuuugaucc cuguuaaaau                                                   20


<210>  26319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26319
uccucggugg acuguaaagg                                                   20


<210>  26320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26320
cuaagcuuug gagggcagau                                                   20


<210>  26321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26321
uagguggacg gauuucuaca                                                   20


<210>  26322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26322
uagauucuua gguggacgga                                                   20


<210>  26323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26323
gcuaaugcuu uucuuagauu                                                   20


<210>  26324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26324
acugaaagau aauucaaaug                                                   20


<210>  26325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26325
guagaaugau agcuuguccc                                                   20


<210>  26326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26326
aauguugggg cuuguucugc                                                   20


<210>  26327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26327
gcaauaaaau auaauggcua                                                   20


<210>  26328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26328
gccuuucugu ucuaacuuua                                                   20


<210>  26329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26329
guucuaacuu uaacuaagga                                                   20


<210>  26330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26330
aacuuuaacu aaggaaaaaa                                                   20


<210>  26331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26331
uuaguuaaag uuagaacaga                                                   20


<210>  26332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26332
uaaauugcau aguauauaaa                                                   20


<210>  26333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26333
guuuucuucc ccuugacauu                                                   20


<210>  26334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26334
uccccuugac auuuacaaaa                                                   20


<210>  26335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26335
ccuugacauu uacaaaauuc                                                   20


<210>  26336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26336
uuuggaagag ugggaucuac                                                   20


<210>  26337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26337
aaaugaauuu uguaaauguc                                                   20


<210>  26338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26338
uuaaaaauac augauuuauc                                                   20


<210>  26339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26339
ccuauugaua uucauuaaaa                                                   20


<210>  26340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26340
cuagccagag agguaguguu                                                   20


<210>  26341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26341
uuaaaucauu aaaacagccu                                                   20


<210>  26342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26342
auagccuuaa aaugauuagu                                                   20


<210>  26343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26343
uaaacacuaa ucauuuuaag                                                   20


<210>  26344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26344
auuugauggu aaguuuaaau                                                   20


<210>  26345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26345
aaacacagug gaaaaaaaaa                                                   20


<210>  26346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26346
acuguguuuu gaaggguuag                                                   20


<210>  26347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26347
agcaguuagc uggcugggau                                                   20


<210>  26348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26348
uuuauguuua gcuacaguau                                                   20


<210>  26349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26349
ucuucccuuu cuacgacuag                                                   20


<210>  26350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26350
cuuucuacga cuaggaaggg                                                   20


<210>  26351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26351
acgacuagga aggggaggga                                                   20


<210>  26352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26352
uagucguaga aagggaagau                                                   20


<210>  26353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26353
cccaucuccu cuccucuccc                                                   20


<210>  26354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26354
auuucauaug uugggcuaua                                                   20


<210>  26355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26355
uauguugggc uauaaggaau                                                   20


<210>  26356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26356
uuauagccca acauaugaaa                                                   20


<210>  26357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26357
cuaguucagg ucuaaagugg                                                   20


<210>  26358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26358
ggucuaaagu gggcaucugu                                                   20


<210>  26359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26359
cccaaaugua gacagaugcc                                                   20


<210>  26360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26360
agaagagaag gaggggaaaa                                                   20


<210>  26361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26361
agaaaccuag agcuucuccc                                                   20


<210>  26362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26362
cuucuagaaa ccuagagcuu                                                   20


<210>  26363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26363
ccuccuucuc uucuagaaac                                                   20


<210>  26364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26364
ugaccacacu gcucaaaccu                                                   20


<210>  26365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26365
gcaaagaaga cugaggcaga                                                   20


<210>  26366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26366
uugcagaaag ccucccugac                                                   20


<210>  26367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26367
ccagggaaag ugaucugaga                                                   20


<210>  26368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26368
cuggugaaaa gccaucugcc                                                   20


<210>  26369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26369
uuuggaguaa ggagcuggcu                                                   20


<210>  26370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26370
uucuuuugga guaaggagcu                                                   20


<210>  26371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26371
gugugugugu gcugugaccu                                                   20


<210>  26372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26372
gcaauauccu cgugggugac                                                   20


<210>  26373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26373
gauaaugguu ucguaacauu                                                   20


<210>  26374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26374
ucugauaaug guuucguaac                                                   20


<210>  26375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26375
aaguuaaaca gaccucccag                                                   20


<210>  26376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26376
aaaguucaaa guuaaacaga                                                   20


<210>  26377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26377
gaguuagaaa cagggaaaga                                                   20


<210>  26378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26378
aacucagaau acacucagca                                                   20


<210>  26379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26379
cuguuucuaa cucagaauac                                                   20


<210>  26380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26380
uuaagucuuu cccuguuucu                                                   20


<210>  26381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26381
ucugacaucc auuuucuuua                                                   20


<210>  26382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26382
uuggauacuc acccaccuuc                                                   20


<210>  26383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26383
cuaaaugagg ccacucaccc                                                   20


<210>  26384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26384
uuacucagag cugucgcugu                                                   20


<210>  26385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26385
ugggccuugg gggcaagaau                                                   20


<210>  26386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26386
ugcccccaag gcccaagaau                                                   20


<210>  26387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26387
caaagacaag gaguaguaau                                                   20


<210>  26388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26388
ucucccuucc caaagacaag                                                   20


<210>  26389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26389
agaugagcca uugucaucua                                                   20


<210>  26390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26390
uuagaugaca auggcucauc                                                   20


<210>  26391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26391
uggcaugugu uggguacucc                                                   20


<210>  26392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26392
ucuuuucucu cucucucugu                                                   20


<210>  26393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26393
caccacgaga auaguauggg                                                   20


<210>  26394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26394
acuuuugcau cuuccucauu                                                   20


<210>  26395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26395
ucauucucuc uuugccugcu                                                   20


<210>  26396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26396
cucuuugccu gcugccaucc                                                   20


<210>  26397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26397
aucuuacaug gauggcagca                                                   20


<210>  26398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26398
ccuccuugcc uuccaucaug                                                   20


<210>  26399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26399
cuagccgugu ggaacuguga                                                   20


<210>  26400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26400
acacggcuag ggaagccuca                                                   20


<210>  26401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26401
uuuguaaauu gcccagucuc                                                   20


<210>  26402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26402
gaguccuuuu ugcaaaggug                                                   20


<210>  26403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26403
acacccaaau acgugcaugc                                                   20


<210>  26404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26404
uccacucccc caaccuaccc                                                   20


<210>  26405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26405
cucugucucu cuguuaauga                                                   20


<210>  26406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26406
ccucaagagg cacaugucag                                                   20


<210>  26407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26407
agguucaccu caagaggcac                                                   20


<210>  26408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26408
uguaagccac ccaaaucucc                                                   20


<210>  26409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26409
ugauggaaag aaaaaaagaa                                                   20


<210>  26410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26410
aucaagaauu acauauuugg                                                   20


<210>  26411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26411
uuccaucaag aauuacauau                                                   20


<210>  26412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26412
uuuuuucuuu ccaucaagaa                                                   20


<210>  26413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26413
aauuggagga uauugcauau                                                   20


<210>  26414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26414
gacucuguuu uugagcacug                                                   20


<210>  26415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26415
ugaaacagcu gcugcugauu                                                   20


<210>  26416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26416
agaacacagu gcucaaaaac                                                   20


<210>  26417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26417
gaauucugac ccuacuuguu                                                   20


<210>  26418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26418
gaaucagcag cagcuguuuc                                                   20


<210>  26419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26419
gacccuacuu guuauuugcu                                                   20


<210>  26420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26420
gcugugccuc ugagagcauu                                                   20


<210>  26421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26421
guaaucacaa auccaguugu                                                   20


<210>  26422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26422
guuaaaacaa cuggauuugu                                                   20


<210>  26423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26423
uauuuucugu uaaaacaacu                                                   20


<210>  26424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26424
gcauaaaacu ucauauuuuc                                                   20


<210>  26425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26425
aaauuuuaaa accugucuuc                                                   20


<210>  26426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26426
cauaaagcuu ucuaaauuuu                                                   20


<210>  26427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26427
aagagcgggg aaucccauaa                                                   20


<210>  26428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26428
ccgcucuuug aaaaucacag                                                   20


<210>  26429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26429
acuuuaaauu ccgucgucuc                                                   20


<210>  26430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26430
gucgucuccu ggcgagugga                                                   20


<210>  26431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26431
acucgccagg agacgacgga                                                   20


<210>  26432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26432
auuuuggguc caaaaccgcu                                                   20


<210>  26433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26433
uguaugugca aagccacuug                                                   20


<210>  26434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26434
aguggcuuug cacauacagg                                                   20


<210>  26435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26435
aauagguccu ggcugggagu                                                   20


<210>  26436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26436
gggaucauuu ccaauagguc                                                   20


<210>  26437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26437
ccuuuguccc aacuuucugg                                                   20


<210>  26438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26438
cagcaggaga gaaagugccu                                                   20


<210>  26439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26439
cuccugcuga gaaauuaaca                                                   20


<210>  26440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26440
gaugauucau uucaaguggg                                                   20


<210>  26441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26441
uuucaagugg gcugaaaaca                                                   20


<210>  26442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26442
agugggcuga aaacaagugg                                                   20


<210>  26443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26443
gcccacuuga aaugaaucau                                                   20


<210>  26444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26444
ggccuuaccg gcagggacug                                                   20


<210>  26445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26445
ccuacaaaag gguaaucaua                                                   20


<210>  26446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26446
cagucucuug gcuuucuccu                                                   20


<210>  26447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26447
aaccccaauu gauaauggca                                                   20


<210>  26448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26448
ccaagauuau acucugauua                                                   20


<210>  26449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26449
gcuucuccaa gauuauacuc                                                   20


<210>  26450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26450
ccuaacagug uacuacauaa                                                   20


<210>  26451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26451
agacuuucuc cuaacagugu                                                   20


<210>  26452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26452
gugagcuuga uugauguggg                                                   20


<210>  26453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26453
gugugcccag accuguucua                                                   20


<210>  26454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26454
aggagcuuga aggcaauaaa                                                   20


<210>  26455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26455
gagucgacug gcaggaucuu                                                   20


<210>  26456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26456
ucugagucga cuggcaggau                                                   20


<210>  26457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26457
ucaucaauaa agcaauuaca                                                   20


<210>  26458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26458
cucacuaacu aguugaagca                                                   20


<210>  26459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26459
acuaguuagu gagagaauua                                                   20


<210>  26460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26460
ucuaugcuac uguuuuggug                                                   20


<210>  26461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26461
cuuucaucua ugcuacuguu                                                   20


<210>  26462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26462
caauauaaau guagaccguu                                                   20


<210>  26463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26463
aucuuguugc uccauuauuc                                                   20


<210>  26464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26464
uaauacacag cuucuaucuc                                                   20


<210>  26465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26465
aucucauggu ccaacauggc                                                   20


<210>  26466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26466
ggaaugcgug cauacuuuuc                                                   20


<210>  26467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26467
agaaauuacu uuuuuuaugu                                                   20


<210>  26468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26468
cuuuaaggac acuuccuugg                                                   20


<210>  26469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26469
uuggaguuac acacacuucu                                                   20


<210>  26470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26470
uaugcuugca accuauuggu                                                   20


<210>  26471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26471
aaccaauagg uugcaagcau                                                   20


<210>  26472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26472
uaccauacau uuccuccucu                                                   20


<210>  26473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26473
gugguaagua guuucuuacc                                                   20


<210>  26474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26474
uuugaggaag acuguggaac                                                   20


<210>  26475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26475
ucaaaggaac uugaguucug                                                   20


<210>  26476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26476
acagucuucc ucaaaggaac                                                   20


<210>  26477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26477
cugggaguuc cacagucuuc                                                   20


<210>  26478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26478
agugacuuca cugggaguuc                                                   20


<210>  26479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26479
guaacuugcu ugaugucaug                                                   20


<210>  26480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26480
gguugcaagu gauagaggcc                                                   20


<210>  26481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26481
aauuagcuua cauuaaaaag                                                   20


<210>  26482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26482
gacaugccua aagcuggaca                                                   20


<210>  26483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26483
cucugggacu ggcaucauuc                                                   20


<210>  26484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26484
caggcagguu cucuuuucaa                                                   20


<210>  26485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26485
guuguguuau gguuugaguu                                                   20


<210>  26486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26486
ucccuuagua uaguacuuac                                                   20


<210>  26487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26487
ugccaggucc cugccugaca                                                   20


<210>  26488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26488
gcauggguug ugauuccugc                                                   20


<210>  26489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26489
gucagaugcu ucugcauggg                                                   20


<210>  26490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26490
ggagaaagcc ucugaggacc                                                   20


<210>  26491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26491
ccagaaacac gacaugacua                                                   20


<210>  26492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26492
uaguaugccu gaagacaaau                                                   20


<210>  26493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26493
ggcauacuaa gaauaacuuu                                                   20


<210>  26494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26494
gauuugucuu caggcauacu                                                   20


<210>  26495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26495
uauggacuuu cugauuuguc                                                   20


<210>  26496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26496
aaaagucucc auuggugauc                                                   20


<210>  26497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26497
ucacccucaa aaagucugug                                                   20


<210>  26498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26498
gcagagcaug cgacacauac                                                   20


<210>  26499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26499
gaaggcugag gaaugucuac                                                   20


<210>  26500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26500
gaaagcuggu uucagcagag                                                   20


<210>  26501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26501
ucagccuuca gaaagcuggu                                                   20


<210>  26502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26502
guagacauuc cucagccuuc                                                   20


<210>  26503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26503
uugcuuuaca uuuuaagaca                                                   20


<210>  26504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26504
gaucauggug agauucaaua                                                   20


<210>  26505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26505
auaauuuuau uuauuuauuu                                                   20


<210>  26506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26506
cauagacagu ucacccucca                                                   20


<210>  26507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26507
cccuccaggg ccccacccuc                                                   20


<210>  26508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26508
aaguaaaaau agaggguggg                                                   20


<210>  26509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26509
cuacaccuca cagcugggau                                                   20


<210>  26510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26510
gugcucaaau cccagcugug                                                   20


<210>  26511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26511
uauaagugau augcaucuca                                                   20


<210>  26512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26512
uaucauucuu auaagugaua                                                   20


<210>  26513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26513
ugcuauucuu aucauucuua                                                   20


<210>  26514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26514
uuuugguuuu ugucaucaca                                                   20


<210>  26515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26515
ucaccuauaa aaaggaagug                                                   20


<210>  26516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26516
uuuuuauagg ugaggaaaca                                                   20


<210>  26517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26517
uugaacacuu auuaauaagu                                                   20


<210>  26518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26518
aagaaauuug cuuuaaaaaa                                                   20


<210>  26519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26519
gcccccaaaa cauuuccccc                                                   20


<210>  26520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26520
cccaucugug uuugauuaac                                                   20


<210>  26521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26521
acggugccuc uuggccuagu                                                   20


<210>  26522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26522
uguuuaauuu uuuuuguuaa                                                   20


<210>  26523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26523
gaugaguagc cgggacucag                                                   20


<210>  26524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26524
gagucccggc uacucaucag                                                   20


<210>  26525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26525
aaacucuauc agaacuugac                                                   20


<210>  26526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26526
gauagaguuu ugaaaucucc                                                   20


<210>  26527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26527
cccgagggga ccaaaaccau                                                   20


<210>  26528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26528
gaucauguag cauauauuuu                                                   20


<210>  26529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26529
caauacuggc aaauuuuugu                                                   20


<210>  26530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26530
aaugauucca aaaucaagcu                                                   20


<210>  26531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26531
aaaaucaagc ucgcugaaua                                                   20


<210>  26532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26532
gcgagcuuga uuuuggaauc                                                   20


<210>  26533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26533
aaaagagggc cacaaacauu                                                   20


<210>  26534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26534
gguuugaccc guacauaaug                                                   20


<210>  26535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26535
aaauucgggu uugacccgua                                                   20


<210>  26536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26536
auucuaaauu cggguuugac                                                   20


<210>  26537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26537
cccuuucaau ucuaaauucg                                                   20


<210>  26538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26538
gaccccuccc accacuguuc                                                   20


<210>  26539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26539
gggacaccag acuuuucuuc                                                   20


<210>  26540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26540
ucucaggaaa cucugcaacc                                                   20


<210>  26541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26541
caggaaacuc ugcaaccagg                                                   20


<210>  26542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26542
ugagaagaaa agucuggugu                                                   20


<210>  26543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26543
auauugcguu gugauuuuug                                                   20


<210>  26544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26544
uuaugagggu uuagaggacu                                                   20


<210>  26545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26545
cucacauucu aucagauaaa                                                   20


<210>  26546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26546
aucagauaaa uccuaacugg                                                   20


<210>  26547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26547
caguguguug ugcucucacc                                                   20


<210>  26548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26548
agcuccaaca ucuugcaguu                                                   20


<210>  26549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26549
uucccagaug agauuuuauu                                                   20


<210>  26550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26550
cagaugagau uuuauuuugc                                                   20


<210>  26551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26551
ggagguauga gugcaaaaua                                                   20


<210>  26552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26552
gucuguagga uggaguuucc                                                   20


<210>  26553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26553
caauguguau uucaaggaac                                                   20


<210>  26554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26554
aggaacacug uuugcuuggu                                                   20


<210>  26555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26555
uugaaauaca cauugggaaa                                                   20


<210>  26556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26556
aaaccuauga ccauggaccu                                                   20


<210>  26557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26557
ucauguaagg gcuucucaga                                                   20


<210>  26558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26558
uguaagggcu ucucagagcc                                                   20


<210>  26559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26559
cagagccauu caaaugcuga                                                   20


<210>  26560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26560
aaugcugaug cauuccauga                                                   20


<210>  26561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26561
uguuugggga aaagcauuug                                                   20


<210>  26562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26562
ccaaacaaga aggagaccca                                                   20


<210>  26563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26563
uuagcacaaa aaccaaaugc                                                   20


<210>  26564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26564
uuauuguagu uuucugacuc                                                   20


<210>  26565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26565
gacuccucuc cuacuguuuu                                                   20


<210>  26566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26566
aaaugccuaa aacaguagga                                                   20


<210>  26567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26567
gaauauaagu cucaaaauac                                                   20


<210>  26568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26568
gaaauguuag aggcagagga                                                   20


<210>  26569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26569
aaucaggccc uggauuuuac                                                   20


<210>  26570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26570
ucugaaagua acaagcauuc                                                   20


<210>  26571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26571
gaggaaccca ugcuauguaa                                                   20


<210>  26572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26572
ccuuaugagg gauuuccaaa                                                   20


<210>  26573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26573
aaauuuagaa augcaaaaua                                                   20


<210>  26574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26574
aaauuuggaa aucccucaua                                                   20


<210>  26575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26575
aaaccagacg uuauucuuaa                                                   20


<210>  26576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26576
uaagaaucac agaagaguca                                                   20


<210>  26577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26577
uaagaauaac gucugguuuu                                                   20


<210>  26578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26578
gugauucuua agaauaacgu                                                   20


<210>  26579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26579
caccucccuu uaaccccucc                                                   20


<210>  26580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26580
cgcccuguug gagggguuaa                                                   20


<210>  26581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26581
agugguaaga auuauauuug                                                   20


<210>  26582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26582
uaccacugga aagcaaggcc                                                   20


<210>  26583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26583
gagacaucug ucauggcagc                                                   20


<210>  26584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26584
cagggagcua acuuuagcag                                                   20


<210>  26585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26585
gcaucugcug gcggaguuug                                                   20


<210>  26586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26586
caauggcuga cucucucucg                                                   20


<210>  26587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26587
caggauauau uaaauguccu                                                   20


<210>  26588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26588
uaacguguaa gcuauuuuua                                                   20


<210>  26589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26589
uccaaguuaa caagcagucc                                                   20


<210>  26590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26590
gacuucaaaa uaaauaaaaa                                                   20


<210>  26591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26591
aaauaaauaa aaaagauuuu                                                   20


<210>  26592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26592
auaacucaga uuucuccucu                                                   20


<210>  26593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26593
ccucugggca ggccagcaaa                                                   20


<210>  26594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26594
ccaaauaaag ucuuucuuuc                                                   20


<210>  26595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26595
uucauaggcu cccugacucu                                                   20


<210>  26596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26596
uaggcucccu gacucuccca                                                   20


<210>  26597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26597
cuuguacuua aucuccucaa                                                   20


<210>  26598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26598
aauaugucca caauuucuuu                                                   20


<210>  26599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26599
uuaacacuuc ucucuucaaa                                                   20


<210>  26600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26600
cucuucaaaa ggcggaguuu                                                   20


<210>  26601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26601
aaaggcggag uuucauuacc                                                   20


<210>  26602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26602
uuaccuuccc cucacaugug                                                   20


<210>  26603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26603
aacaaacagc gaaaugaugu                                                   20


<210>  26604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26604
cuguuuguua gaaguuuauc                                                   20


<210>  26605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26605
aaggcugguu uauaaaaagc                                                   20


<210>  26606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26606
ccugccucag ccucccaagc                                                   20


<210>  26607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26607
agcaauucuc cugccucagc                                                   20


<210>  26608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26608
uggagcccua acacugcacu                                                   20


<210>  26609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26609
uuucuguggg gaggcugcca                                                   20


<210>  26610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26610
guggggaggc ugccaccacg                                                   20


<210>  26611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26611
uuuauuugua caggaaugcu                                                   20


<210>  26612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26612
uaaaaaguuu cuuggccccu                                                   20


<210>  26613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26613
uggccccuau aacaaugaga                                                   20


<210>  26614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26614
cugagugggg aaguucucaa                                                   20


<210>  26615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26615
ccacucagag aaagagucau                                                   20


<210>  26616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26616
caaguuuuaa ucuuaauagc                                                   20


<210>  26617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26617
aagauaagua uguacaugug                                                   20


<210>  26618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26618
aaaaagggcc caucuggaga                                                   20


<210>  26619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26619
uuccaaaaag ggcccaucug                                                   20


<210>  26620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26620
aaauccucac aaaugcauug                                                   20


<210>  26621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26621
cccaaugacc acagaacccc                                                   20


<210>  26622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26622
cuacuauugg acuucuccag                                                   20


<210>  26623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26623
ccaggccuuu aauauggaau                                                   20


<210>  26624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26624
auauuaaagg ccuggagaag                                                   20


<210>  26625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26625
ucauguggca ccaaaauaag                                                   20


<210>  26626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26626
caaacucacu ucaucacaaa                                                   20


<210>  26627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26627
augagcucuu ugugaugaag                                                   20


<210>  26628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26628
uuggggcagg ucucacccag                                                   20


<210>  26629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26629
auuuucauug gggcaggucu                                                   20


<210>  26630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26630
gcuuugaucu gcuuccaaca                                                   20


<210>  26631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26631
aacaagucuu aggaauguac                                                   20


<210>  26632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26632
uaagacuugu uggaagcaga                                                   20


<210>  26633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26633
ccuguacauu ccuaagacuu                                                   20


<210>  26634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26634
uuaaagacgu agaucuggaa                                                   20


<210>  26635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26635
agaucuacgu cuuuaaggaa                                                   20


<210>  26636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26636
aagaaccuuu aaaccaaaau                                                   20


<210>  26637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26637
uugaauucca gaucuacguc                                                   20


<210>  26638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26638
ccccaaggac agaaagaaua                                                   20


<210>  26639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26639
guccuugggg agaaaauggg                                                   20


<210>  26640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26640
cugucuaggc aucccaggcu                                                   20


<210>  26641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26641
aaaagucccc guaaagacuc                                                   20


<210>  26642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26642
gagucuuuac ggggacuuuu                                                   20


<210>  26643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26643
uuucagaguc uuuacgggga                                                   20


<210>  26644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26644
uucauuucag agucuuuacg                                                   20


<210>  26645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26645
ccucucuccc ccucccucau                                                   20


<210>  26646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26646
uucaacauug acccauuuug                                                   20


<210>  26647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26647
acauugaccc auuuuguuca                                                   20


<210>  26648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26648
ggucuaacaa cucaaaagca                                                   20


<210>  26649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26649
augacucugc ugcuuuugag                                                   20


<210>  26650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26650
uguuggccag acaagcaaac                                                   20


<210>  26651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26651
caugaccucu guaugauaaa                                                   20


<210>  26652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26652
caguuaucau ccaagcacug                                                   20


<210>  26653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26653
ggcucaguuu auuauaacgu                                                   20


<210>  26654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26654
cccacacguu auaauaaacu                                                   20


<210>  26655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26655
ccugcacaga aagucaaauc                                                   20


<210>  26656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26656
gugcaggaga acgugcaaca                                                   20


<210>  26657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26657
gacacuuaaa aagacacugu                                                   20


<210>  26658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26658
cacacguaca caagaagauc                                                   20


<210>  26659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26659
uguguacgug ugggaaagug                                                   20


<210>  26660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26660
uuugaguguc ucuggcaugc                                                   20


<210>  26661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26661
caguagucuc guuucuuuua                                                   20


<210>  26662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26662
uuuacagcug aguauuucac                                                   20


<210>  26663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26663
cggcagaauu guuccuggau                                                   20


<210>  26664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26664
gccgugaaau acucagcugu                                                   20


<210>  26665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26665
uggauaaagc ugcaaguaac                                                   20


<210>  26666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26666
cuagagucau aauauugaau                                                   20


<210>  26667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26667
auauuaugac ucuagggaaa                                                   20


<210>  26668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26668
ugggucucau ucaauauuau                                                   20


<210>  26669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26669
ccagcaaaug cucucaagag                                                   20


<210>  26670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26670
aagauccuac cucucuccca                                                   20


<210>  26671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26671
uggucccuag ggacaauuca                                                   20


<210>  26672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26672
gggugaggga ggaaguccug                                                   20


<210>  26673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26673
ucccucaccc ugaauugucc                                                   20


<210>  26674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26674
ugggauguca uuauguaucc                                                   20


<210>  26675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26675
caauccuauc cccaaaagga                                                   20


<210>  26676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26676
uuuuggggau aggauuguga                                                   20


<210>  26677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26677
uuaacuuguc uuuccuuuug                                                   20


<210>  26678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26678
ccaucucaca uucuuuaacu                                                   20


<210>  26679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26679
ugccagaaug caguucucuu                                                   20


<210>  26680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26680
ggcaggaauu ccccaucuca                                                   20


<210>  26681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26681
cuuuagaauu cacuucuucc                                                   20


<210>  26682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26682
aaagagaacu gcauucuggc                                                   20


<210>  26683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26683
cuucuuccaa uaguccaaca                                                   20


<210>  26684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26684
uccaauaguc caacaagucu                                                   20


<210>  26685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26685
aauaguccaa caagucuagg                                                   20


<210>  26686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26686
agacuggaau acacaaaagc                                                   20


<210>  26687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26687
agucuagaaa gcuguuucuu                                                   20


<210>  26688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26688
aaggaaauca acaauacuuu                                                   20


<210>  26689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26689
uuugaaaaau cacugcuuuu                                                   20


<210>  26690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26690
gcagauuuuu guggggagac                                                   20


<210>  26691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26691
aauacaaaau agaggauuug                                                   20


<210>  26692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26692
aaauccucua uuuuguauug                                                   20


<210>  26693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26693
uccaaauccu cuauuuugua                                                   20


<210>  26694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26694
cuuuauucuu ccaaauccuc                                                   20


<210>  26695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26695
uaucccuggc uggggagcuu                                                   20


<210>  26696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26696
ucccuucuug uguaugugug                                                   20


<210>  26697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26697
ucccucccuc ccuuccuccc                                                   20


<210>  26698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26698
ucccucccuc ccucccucca                                                   20


<210>  26699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26699
uuccucccuc ccucccuccc                                                   20


<210>  26700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26700
uuccuuccuc ccucccuccc                                                   20


<210>  26701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26701
uuccuuccuu ccucccuccc                                                   20


<210>  26702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26702
uuccuuccuu ccuuccuccc                                                   20


<210>  26703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26703
uucuuuccuu ccuuccuucc                                                   20


<210>  26704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26704
uuccuucuuu ccuuccuucc                                                   20


<210>  26705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26705
uucuuuccuu cuuuccuucc                                                   20


<210>  26706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26706
uuccuucuuu ccuucuuucc                                                   20


<210>  26707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26707
uuccuuccuu cuuuccuucu                                                   20


<210>  26708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26708
cccucccuuu uuuccuuccu                                                   20


<210>  26709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26709
uuucucccuc ccuuuuuucc                                                   20


<210>  26710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26710
cugcuucuuu ucucccuccc                                                   20


<210>  26711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26711
uucccugcuu cuuuucuccc                                                   20


<210>  26712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26712
uuccuucccu gcuucuuuuc                                                   20


<210>  26713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26713
uuaccuggag cuuagcucag                                                   20


<210>  26714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26714
gagcuaagcu ccagguaaag                                                   20


<210>  26715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26715
uugaguugac uucugagcua                                                   20


<210>  26716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26716
gugacacacu uggucugucu                                                   20


<210>  26717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26717
gaaaaggaaa ugguaccuga                                                   20


<210>  26718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26718
gaaguuuucu gugacacacu                                                   20


<210>  26719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26719
uuuucggaag uuuucuguga                                                   20


<210>  26720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26720
acucagguac cauuuccuuu                                                   20


<210>  26721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26721
aauggcuaac ucucacuaau                                                   20


<210>  26722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26722
uguacccauu uccaauggcu                                                   20


<210>  26723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26723
uccuguaccc auuuccaaug                                                   20


<210>  26724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26724
caauccuccu ggcccucgug                                                   20


<210>  26725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26725
caaagugcua ggauuacagg                                                   20


<210>  26726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26726
gagcucaagu gaucugccca                                                   20


<210>  26727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26727
ggcuggucuc aaacuucuga                                                   20


<210>  26728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26728
cuccacaugg ucaugucugu                                                   20


<210>  26729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26729
ucgcagcaug guggcugcau                                                   20


<210>  26730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26730
cuugugaugc agccaccaug                                                   20


<210>  26731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26731
agucucugcc ucagucuuca                                                   20


<210>  26732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26732
uuggcacgug gcugcaccau                                                   20


<210>  26733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26733
ggcuuuccuu ggcacguggc                                                   20


<210>  26734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26734
ggugacuucu ggcuuuccuu                                                   20


<210>  26735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26735
agcuucuggu gacuucuggc                                                   20


<210>  26736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26736
acguuuuaau uauuuauggu                                                   20


<210>  26737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26737
accagccuaa ugacuugggg                                                   20


<210>  26738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26738
aucaccccaa gucauuaggc                                                   20


<210>  26739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26739
cuuugauuca aucaccccaa                                                   20


<210>  26740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26740
aauagacuuc ucuagagugc                                                   20


<210>  26741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26741
cuagagugca cagcugaagg                                                   20


<210>  26742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26742
gcugugcacu cuagagaagu                                                   20


<210>  26743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26743
cuucagcugu gcacucuaga                                                   20


<210>  26744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26744
uaauagacua acaaaccucu                                                   20


<210>  26745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26745
ucggagaccc caaagguacc                                                   20


<210>  26746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26746
gagaccccaa agguacccgc                                                   20


<210>  26747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26747
uucgagagcc aaaaugagua                                                   20


<210>  26748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26748
agagccaaaa ugaguacaau                                                   20


<210>  26749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26749
ucugugccag ccacaaaacu                                                   20


<210>  26750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26750
uaauuucauc ugugccagcc                                                   20


<210>  26751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26751
acuaacaaau uccuaauuuc                                                   20


<210>  26752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26752
auacgcugau uuuccugaca                                                   20


<210>  26753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26753
ugacaacccu cucauggucg                                                   20


<210>  26754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26754
cucauccaaa uauuuccacu                                                   20


<210>  26755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26755
acuucgcuca aaauggauuc                                                   20


<210>  26756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26756
cucaaaaugg auuccaaaca                                                   20


<210>  26757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26757
aaacaguccu gggauucuca                                                   20


<210>  26758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26758
cagggaugcu uucaauuccu                                                   20


<210>  26759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26759
auuccuuuuc cuagcuagac                                                   20


<210>  26760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26760
uuuuccuagc uagaccaucu                                                   20


<210>  26761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26761
uagcuagacc aucuuuuaga                                                   20


<210>  26762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26762
gcuuaaaacu cucacccuuc                                                   20


<210>  26763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26763
uugcaaagcu uaaauggaaa                                                   20


<210>  26764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26764
auuuaagcuu ugcaaggaag                                                   20


<210>  26765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26765
ugggaacucg ggucccuccu                                                   20


<210>  26766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26766
caggaaaucu aaauuaauaa                                                   20


<210>  26767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26767
uuacuagccc uggccaggag                                                   20


<210>  26768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26768
uuaucuuuaa uaggauuucu                                                   20


<210>  26769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26769
cuaaacuuuu ugggcuggua                                                   20


<210>  26770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26770
ugaaaggugu agagggacag                                                   20


<210>  26771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26771
ggaaaacuac cagcccaaaa                                                   20


<210>  26772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26772
gucccucuac accuuucagg                                                   20


<210>  26773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26773
uugcaaggca caaagcugcg                                                   20


<210>  26774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26774
cuaaggacuu auccacagug                                                   20


<210>  26775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26775
ccucauguug aguucucuaa                                                   20


<210>  26776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26776
ucuccucaug uugaguucuc                                                   20


<210>  26777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26777
ccaucuucuu cuccucaugu                                                   20


<210>  26778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26778
uuucuccauc uucuucuccu                                                   20


<210>  26779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26779
gauuccuuuc uccaucuucu                                                   20


<210>  26780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26780
cucccuccuc uuugccuuuu                                                   20


<210>  26781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26781
ccacuuucuc ucccuccucu                                                   20


<210>  26782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26782
ccuucaccac uuucucuccc                                                   20


<210>  26783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26783
uucuccuuca ccacuuucuc                                                   20


<210>  26784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26784
uuucccuaua cccuaaguuu                                                   20


<210>  26785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26785
ccaccuuucu auaccagucu                                                   20


<210>  26786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26786
auaccagucu cuaaaucaag                                                   20


<210>  26787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26787
ugcuggggga agugguuugc                                                   20


<210>  26788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26788
cccagcaaga aauaaaaaau                                                   20


<210>  26789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence TTCN PAM

<400>  26789
aaguuauagc aaauaauaaa                                                   20


<210>  26790
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  26790
acccttcctg gagcctgtga taaaagcaac tgttagctt                              39


<210>  26791
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  26791
tgggaaggac ctcggacact attttcgttg acaatcgaa                              39


<210>  26792
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  26792

Pro Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro 
1               5                   10                  15      


Thr 
    


<210>  26793
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain


<220>
<221>  SITE
<222>  (4)..(50)
<223>  individual amino acid residues may be present or absent

<400>  26793

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg 
    50  


<210>  26794
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26794
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  26795
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26795
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucagag                                97


<210>  26796
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26796
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  26797
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26797
acuggcacuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  26798
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26798
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  26799
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26799
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agcgccuuac ggacuucggu ccguaaggag caucagag                               98


<210>  26800
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26800
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuucgg uccguaagag gcaucagag                              99


<210>  26801
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26801
acgggacuuu cuaucugauu acucugaagu cccucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  26802
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26802
accuguaguu cuaucugauu acucugacua cagucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  26803
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26803
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             113


<210>  26804
<211>  143
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26804
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg ugcagcauca aag                                              143


<210>  26805
<211>  173
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26805
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             173


<210>  26806
<211>  203
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26806
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      180

cgguacaccg ugcagcauca aag                                              203


<210>  26807
<211>  233
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26807
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      180

cgguacaccg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             233


<210>  26808
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26808
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc uagcggaggc uaggugcagc aucaaag                                97


<210>  26809
<211>  118
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26809
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc ucggcuugcu gaagcgcgca cggcaagagg cgaggugcag caucaaag        118


<210>  26810
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26810
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc ucucucgacg caggacucgg cuugcugaag cgcgcacggc aagaggcgag      120

gggcggcgac uggugaguac gccaaaaauu uugacuagcg gaggcuagaa ggagagaggu      180

gcagcaucaa ag                                                          192


<210>  26811
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26811
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugcccgucu guugugucga gagacgccaa aaauuuugac uagcggaggc      120

uagaaggaga gagaugggug ccgugcagca ucaaag                                156


<210>  26812
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26812
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca uggagaggag augugcagca ucaaag                                 96


<210>  26813
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26813
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca uggagaugug cagcaucaaa g                                      91


<210>  26814
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26814
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcuugggc gcagcgucaa ugacgcugac gguacaagca ucaaag                     106


<210>  26815
<211>  145
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26815
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau gaggaucacc      120

caugugguau agugcagcau caaag                                            145


<210>  26816
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26816
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  26817
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26817
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau ggcagucgua      120

acgacgcggg ugguauagug cagcaucaaa g                                     151


<210>  26818
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26818
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caaacauggc aguccuaagg acgcggguuu ugcugacggu      120

acaggccaca uggcagucgu aacgacgcgg gugguauagu gcagcaucaa ag              172


<210>  26819
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26819
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag acauggcagu cguaacgacg cgggucugac gguacaggcc      120

acaugaggau cacccaugug guauagugca gcaucaaag                             159


<210>  26820
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26820
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu aaggaguuua uauggaaacc cuuagugcag caucaaag                   108


<210>  26821
<211>  242
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26821
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucagga agcacuaugg gcgcagcguc aaugacgcug acgguacagg ccagacaauu      120

auugucuggu auagugcagc agcagaacaa uuugcugagg gcuauugagg cgcaacagca      180

ucuguugcaa cucacagucu ggggcaucaa gcagcuccag gcaagaaucc ugagcaucaa      240

ag                                                                     242


<210>  26822
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26822
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg cccugaagaa gggcgugcag caucaaag                               98


<210>  26823
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26823
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gcucguguag cucauuagcu ccgagccgug cagcaucaaa g               111


<210>  26824
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26824
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc cgugugcauc cgcagugucg gauccacggg ugcagcauca aag             113


<210>  26825
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26825
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gaauccauug cacuccggau uucacuaggu gcagcaucaa ag              112


<210>  26826
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26826
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca ugcaugucua agacagcaug ugcagcauca aag                        103


<210>  26827
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26827
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca aaacauaagg aaaaccuaug uugugcagca ucaaag                     106


<210>  26828
<211>  153
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26828
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcguc aaugacgcug acgguacagg ccagacaauu      120

auugucuggu auaguccgua agaggcauca gag                                   153


<210>  26829
<211>  147
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26829
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgggugggcg cagcgucaau gacgcugacg guacaggcca gacaauuauu      120

gucugguacc cguaagaggc aucagag                                          147


<210>  26830
<211>  153
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26830
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcgucaa ugacgcugac gguacaggcc acaugaggau      120

cacccaugug guauaccgua agaggcauca gag                                   153


<210>  26831
<211>  143
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26831
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc gucaaugacg cugacgguac aggccacaug aggaucaccc      120

augugguaua gggagcauca aag                                              143


<210>  26832
<211>  163
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26832
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcucaug aggaucaccc augagcugac gguacaggcc      120

acaugaggau cacccaugug guauaccgua agaggcauca gag                        163


<210>  26833
<211>  153
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26833
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc ucaugaggau cacccaugag cugacgguac aggccacaug      120

aggaucaccc augugguaua gggagcauca aag                                   153


<210>  26834
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26834
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcgucaa ugacgcugac gguacaggcc acauggcagu      120

cguaacgacg cgggugguau accguaagag gcaucagag                             159


<210>  26835
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26835
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc gucaaugacg cugacgguac aggccacaug gcagucguaa      120

cgacgcgggu gguauaggga gcaucaaag                                        149


<210>  26836
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26836
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcaaaca uggcaguccu aaggacgcgg guuuugcuga      120

cgguacaggc cacauggcag ucguaacgac gcggguggua uaccguaaga ggcaucagag      180


<210>  26837
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26837
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc aaacauggca guccuaagga cgcggguuuu gcugacggua      120

caggccacau ggcagucgua acgacgcggg ugguauaggg agcaucaaag                 170


<210>  26838
<211>  167
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26838
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagacaugg cagucguaac gacgcggguc ugacgguaca      120

ggccacauga ggaucaccca ugugguauac cguaagaggc aucagag                    167


<210>  26839
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  26839
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcaga cauggcaguc guaacgacgc gggucugacg guacaggcca      120

caugaggauc acccaugugg uauagggagc aucaaag                               157


<210>  26840
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26840

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26841
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26841

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26842
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26842

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26843
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26843

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26844
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26844

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26845
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26845

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26846
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26846

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26847
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26847

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26848
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26848

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26849
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26849

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26850
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26850

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26851
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26851

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26852
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26852

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26853
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26853

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26854
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26854

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26855
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26855

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26856
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26856

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26857
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26857

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26858
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26858

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26859
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26859

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26860
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26860

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26861
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26861

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26862
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26862

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26863
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26863

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26864
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26864

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26865
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26865

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26866
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26866

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26867
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26867

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26868
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26868

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26869
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26869

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26870
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26870

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26871
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26871

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26872
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26872

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26873
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26873

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26874
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26874

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26875
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26875

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26876
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26876

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26877
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26877

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26878
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26878

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26879
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26879

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26880
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26880

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26881
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26881

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26882
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26882

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26883
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26883

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26884
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26884

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  26885
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26885

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  26886
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26886

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  26887
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26887

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  26888
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26888

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26889
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26889

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26890
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26890

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26891
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26891

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26892
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26892

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26893
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26893

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26894
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26894

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  26895
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26895

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26896
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26896

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


<210>  26897
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26897

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26898
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26898

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26899
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26899

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn His Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26900
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26900

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Gln Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26901
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26901

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Thr Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26902
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26902

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Arg Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26903
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26903

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26904
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26904

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Ala Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26905
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26905

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26906
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26906

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Trp Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26907
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26907

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Tyr Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26908
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26908

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26909
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26909

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26910
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26910

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26911
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26911

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26912
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26912

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Thr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26913
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26913

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ala Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26914
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26914

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Val Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26915
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26915

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Leu Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26916
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26916

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asn Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26917
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26917

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gln Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26918
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26918

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ser Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26919
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26919

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ala Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26920
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26920

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26921
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26921

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Thr Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26922
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26922

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Arg Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26923
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26923

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu His 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26924
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26924

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Glu Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26925
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26925

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Ile Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26926
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26926

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Phe Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26927
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26927

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Trp Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26928
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26928

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Asp Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26929
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26929

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26930
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26930

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Asp Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26931
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26931

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Pro Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26932
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26932

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Lys Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26933
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26933

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Lys Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26934
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26934

Gln Glu Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26935
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26935

Gln Glu Glu Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26936
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26936

Gln Glu Ile Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26937
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26937

Gln Glu Ile Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26938
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26938

Gln Glu Ile Ser Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26939
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26939

Gln Glu Ile Lys Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26940
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26940

Gln Glu Ile Lys Ser Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26941
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26941

Gln Glu Ile Lys Arg Ala Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26942
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26942

Gln Glu Ile Lys Arg Gly Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26943
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26943

Gln Glu Ile Lys Arg Ile Ser Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26944
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26944

Gln Glu Ile Lys Arg Ile Asn Gly Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26945
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26945

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Phe 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26946
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26946

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Phe Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26947
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26947

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Pro Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26948
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26948

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Pro Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26949
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26949

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26950
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26950

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26951
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26951

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Ser Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26952
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26952

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Gln Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26953
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26953

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Thr His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26954
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26954

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Gly Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26955
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26955

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Asp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26956
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26956

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Ala Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26957
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26957

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Arg Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26958
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26958

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26959
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26959

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Tyr Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26960
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26960

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ser Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26961
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26961

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Pro Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26962
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26962

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26963
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26963

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26964
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26964

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Gly 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26965
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26965

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Ser 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26966
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26966

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Leu Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26967
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26967

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Thr Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26968
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26968

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Trp Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26969
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26969

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Asn Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26970
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26970

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Gln Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26971
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26971

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Ala Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26972
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26972

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26973
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26973

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Pro 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26974
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26974

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  26975
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26975

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Leu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26976
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26976

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26977
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26977

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26978
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26978

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn His Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26979
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26979

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Ala Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26980
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26980

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26981
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26981

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Pro Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26982
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26982

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Thr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26983
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26983

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Met 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26984
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26984

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Asn His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26985
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26985

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Trp His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26986
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26986

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Tyr Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26987
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26987

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Pro Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26988
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26988

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Glu Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26989
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26989

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Arg Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26990
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26990

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Trp Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26991
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26991

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Tyr Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26992
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26992

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Tyr Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  26993
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26993

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Arg Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26994
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26994

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Asp 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26995
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26995

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Pro 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26996
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26996

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Leu Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26997
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26997

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Gly Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26998
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26998

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Gln Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  26999
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  26999

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Asp Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27000
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27000

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Thr Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27001
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27001

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Thr Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27002
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27002

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Lys Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27003
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27003

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Glu Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27004
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27004

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Ser Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27005
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27005

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Arg Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27006
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27006

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Lys Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27007
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27007

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Ser Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27008
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27008

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27009
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27009

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Gln Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27010
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27010

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Lys Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27011
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27011

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Asp Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27012
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27012

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Val 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27013
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27013

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Asp 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27014
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27014

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Arg Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27015
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27015

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys His Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27016
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27016

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Pro Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27017
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27017

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27018
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27018

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Phe 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27019
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27019

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Val 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27020
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27020

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27021
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27021

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Thr Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27022
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27022

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Asn Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27023
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27023

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Arg Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27024
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27024

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Ser Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27025
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27025

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Trp Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27026
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27026

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Arg Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27027
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27027

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ser Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27028
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27028

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val His 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27029
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27029

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ser Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27030
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27030

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27031
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27031

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Asp Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27032
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27032

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Asn Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27033
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27033

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Val Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27034
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27034

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Ile Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27035
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27035

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27036
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27036

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27037
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27037

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27038
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27038

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27039
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27039

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27040
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27040

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Asp Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27041
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27041

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys His Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27042
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27042

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27043
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27043

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27044
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27044

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27045
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27045

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27046
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27046

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27047
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27047

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27048
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27048

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27049
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27049

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27050
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27050

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27051
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27051

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27052
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27052

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27053
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27053

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27054
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27054

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27055
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27055

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27056
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27056

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27057
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27057

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27058
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27058

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27059
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27059

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27060
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27060

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27061
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27061

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27062
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27062

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27063
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27063

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27064
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27064

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27065
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27065

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27066
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27066

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27067
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27067

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27068
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27068

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27069
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27069

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Ala 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27070
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27070

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Val Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27071
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27071

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Gly Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27072
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27072

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu His Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27073
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27073

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Cys Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27074
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27074

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  27075
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27075

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Gly Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27076
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27076

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Leu Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27077
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27077

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Gln Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27078
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27078

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Ser Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27079
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27079

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Glu Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27080
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27080

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Thr Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27081
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27081

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Asn Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27082
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27082

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Leu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27083
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27083

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  27084
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27084

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  27085
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27085

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Gln Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27086
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27086

Gln Glu Ile Lys Arg Leu Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27087
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27087

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Asp Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27088
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27088

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  27089
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27089

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Val Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27090
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27090

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Gly Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27091
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27091

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Phe Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27092
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27092

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Tyr Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27093
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27093

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Pro Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27094
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27094

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Thr Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27095
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27095

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Cys Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27096
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27096

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Pro 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27097
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27097

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Gly Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27098
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27098

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27099
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27099

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ile Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27100
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27100

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Lys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27101
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27101

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Gln Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27102
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27102

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Tyr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27103
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27103

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Lys Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27104
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27104

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ala Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27105
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27105

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27106
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27106

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27107
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27107

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Trp Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27108
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27108

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


His Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27109
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27109

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Pro Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27110
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27110

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27111
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27111

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27112
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27112

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Phe Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27113
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27113

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Asn Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27114
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27114

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Pro Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27115
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27115

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Trp Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27116
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27116

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Met Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27117
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27117

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27118
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27118

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Val Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27119
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27119

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Pro Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27120
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27120

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Pro Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27121
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27121

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Met Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27122
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27122

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Arg Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27123
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27123

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Phe Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27124
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27124

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  27125
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27125

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Gln Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27126
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27126

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Asn Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27127
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27127

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu His Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27128
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27128

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Val Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27129
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27129

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Gln Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27130
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27130

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Pro Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27131
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27131

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Arg Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27132
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27132

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Trp Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27133
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27133

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Asn Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27134
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27134

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Ser Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27135
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27135

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ser Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27136
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27136

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Arg Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27137
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27137

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Arg Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27138
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27138

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Asp Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27139
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27139

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Gln Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27140
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27140

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Met Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27141
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27141

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Ile Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27142
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27142

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Val Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27143
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27143

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Glu Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27144
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27144

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Met Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27145
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27145

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Gln Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27146
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27146

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Ile Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27147
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27147

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Asn Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27148
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27148

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Gly Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27149
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27149

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Met Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27150
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27150

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Gln Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27151
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27151

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Glu Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  27152
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27152

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Ser Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27153
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27153

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Lys Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27154
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27154

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  27155
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27155
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagttcggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg catcgaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  27156
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27156
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  27157
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27157
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  27158
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27158
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  27159
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27159
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctcttccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  27160
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27160
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctaccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  27161
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27161
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctgccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  27162
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27162
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat taagctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  27163
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27163
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gccccgagga ccggaagaag ggcaagaagt tcgccagata ccagttcggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccaacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggaggaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  27164
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27164
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttcag cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggaggaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  27165
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27165
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaaaacga ccggaagaag ggcaagaagt tcgccagata ccagttcggc     1200

gacctgctga agcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttcag cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agaccctgct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggaggaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  27166
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27166
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gccccgagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccaacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggaggaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  27167
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27167
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gccccgagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaccc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggaggaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  27168
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27168
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctt cccctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  27169
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27169
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctt cccctgtggg caaagccctg tccggcgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  27170
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27170
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat taagctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctcttccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  27171
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27171
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattaagctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctt cccctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  27172
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX Variant

<400>  27172
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattaagctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctt cccctgtggg caaagccctg tccggcgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  27173

<400>  27173
000

<210>  27174

<400>  27174
000

<210>  27175

<400>  27175
000

<210>  27176
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 TTC PAM TS

<400>  27176
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgaatgct gtcagcttca       60


<210>  27177
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 TTC PAM NTS

<400>  27177
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27178
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 CTC PAM TS

<400>  27178
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgagtgct gtcagcttca       60


<210>  27179
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 CTC PAM NTS

<400>  27179
tgaagctgac agcactcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27180
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 GTC PAM TS

<400>  27180
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgactgct gtcagcttca       60


<210>  27181
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 GTC PAM NTS

<400>  27181
tgaagctgac agcagtcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27182
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 ATC PAM TS

<400>  27182
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgattgct gtcagcttca       60


<210>  27183
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 ATC PAM NTS

<400>  27183
tgaagctgac agcaatcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27184
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 TTT PAM TS

<400>  27184
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccaaatgct gtcagcttca       60


<210>  27185
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 TTT PAM NTS

<400>  27185
tgaagctgac agcatttggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27186
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 CTT PAM TS

<400>  27186
agcgcgagca cagctaaggc cacggagcga gacatctcgg ccctagtgct gtcagcttca       60


<210>  27187
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 CTT PAM NTS

<400>  27187
tgaagctgac agcacttggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27188
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 GTT PAM TS

<400>  27188
agcgcgagca cagctaaggc cacggagcga gacatctcgg ccctactgct gtcagcttca       60


<210>  27189
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 GTT PAM NTS

<400>  27189
tgaagctgac agcagttggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27190
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 ATT PAM TS

<400>  27190
agcgcgagca cagctaaggc cacggagcga gacatctcgg ccctattgct gtcagcttca       60


<210>  27191
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7.37 ATT PAM NTS

<400>  27191
tgaagctgac agcaattggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  27192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  27192
ggccgagatg tctcgctccg                                                   20


<210>  27193
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  27193
ggccgagatg tctcgctc                                                     18


<210>  27194
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  27194
ggccgagatg tctcgctcc                                                    19


<210>  27195
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scaffold 174 18-nt spacer primer

<400>  27195
gagcgagaca tctcggccct ttgatgctcc ctcc                                   34


<210>  27196
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scaffold 174 19-nt spacer primer

<400>  27196
ggagcgagac atctcggccc tttgatgctc cctcc                                  35


<210>  27197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.30

<400>  27197
aaggggcucc gcaccacgcc                                                   20


<210>  27198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer 12.7

<400>  27198
cugcauucua guugugguuu                                                   20


<210>  27199
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27199

Pro Ala Lys Arg Ala Arg Arg Gly Tyr Lys Cys 
1               5                   10      


<210>  27200
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27200

Lys Leu Gly Pro Arg Lys Ala Thr Gly Arg Trp 
1               5                   10      


<210>  27201
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27201

Pro Arg Arg Lys Arg Glu Glu 
1               5           


<210>  27202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27202

Pro Tyr Arg Gly Arg Lys Glu 
1               5           


<210>  27203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27203

Pro Leu Arg Lys Arg Pro Arg Arg 
1               5               


<210>  27204
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27204

Pro Leu Arg Lys Arg Pro Arg Arg Gly Ser Pro Leu Arg Lys Arg Pro 
1               5                   10                  15      


Arg Arg 
        


<210>  27205
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27205

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val 
            20                  25                  


<210>  27206
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27206

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Gly Ile His 
            20                  25                  30          


Gly Val Pro Ala Ala 
        35          


<210>  27207
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27207

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Ala Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  27208
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27208

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Pro Gly 
            20                  25                  30      


<210>  27209
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27209

Lys Arg Lys Gly Ser Pro Glu Arg Gly Glu Arg Lys Arg His Trp 
1               5                   10                  15  


<210>  27210
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27210

Lys Arg Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Thr Lys Arg 
1               5                   10                  15      


Lys Val Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
            20                  25              


<210>  27211
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear Localization Signal

<400>  27211

Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Lys Arg Thr Ala Asp Ser 
1               5                   10                  15      


Gln His Ser Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe Glu Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val 
        35              


<210>  27212
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  SITE
<222>  (2)..(5)
<223>  individual amino acid residues may be present or absent

<400>  27212

Gly Gly Gly Gly Gly 
1               5   


<210>  27213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  SITE
<222>  (3)..(4)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (5)..(6)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (7)..(8)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (9)..(10)
<223>  grouped amino acid residues may be present or absent

<400>  27213

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  27214
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  27214

Pro Pro Pro Gly 
1               


<210>  27215
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  SITE
<222>  (8)..(11)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (12)..(15)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (16)..(19)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (20)..(23)
<223>  grouped amino acid residues may be present or absent

<400>  27215

Pro Pro Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser 
            20              


<210>  27216
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  SITE
<222>  (1)..(4)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (5)..(8)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (9)..(12)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (13)..(16)
<223>  grouped amino acid residues may be present or absent

<400>  27216

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Pro Pro Pro 
            20              


<210>  27217
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  27217

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    


<210>  27218
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  27218

Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe Glu 
1               5                   10          


<210>  27219
<211>  141
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27219
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccagac aauuauuguc      120

ugguauagug cagcaucaaa g                                                141


<210>  27220
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27220
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caccugagga ucacccaggu gcugacggua caggccaccu      120

gaggaucacc caggugguau agugcagcau caaag                                 155


<210>  27221
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27221
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgcaugagga ucacccaugc gcugacggua caggccgcau      120

gaggaucacc caugcgguau agugcagcau caaag                                 155


<210>  27222
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27222
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgccugagga ucacccaggc gcugacggua caggccgccu      120

gaggaucacc caggcgguau agugcagcau caaag                                 155


<210>  27223
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27223
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgccugagca ucagccaggc gcugacggua caggccgccu      120

gagcaucagc caggcgguau agugcagcau caaag                                 155


<210>  27224
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27224
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagca ucagccaugu gcugacggua caggccacau      120

gagcaucagc caugugguau agugcagcau caaag                                 155


<210>  27225
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27225
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagua ucaaccaugu gcugacggua caggccacau      120

gaguaucaac caugugguau agugcagcau caaag                                 155


<210>  27226
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27226
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagaa ucagccaugu gcugacggua caggccacau      120

gagaaucagc caugugguau agugcagcau caaag                                 155


<210>  27227
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27227
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cccuugagga ucacccaugu gcugacggua caggccccuu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  27228
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27228
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacuugagga ucacccaugu gcugacggua caggccacuu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  27229
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27229
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caccugagga ucacccaugu gcugacggua caggccaccu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  27230
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27230
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ucaccuaugu gcugacggua caggccacau      120

gaggaucacc uaugugguau agugcagcau caaag                                 155


<210>  27231
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27231
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccaaugu gcugacggua caggccacau      120

uaggaucacc aaugugguau agugcagcau caaag                                 155


<210>  27232
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27232
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccgaugu gcugacggua caggccacau      120

uaggaucacc gaugugguau agugcagcau caaag                                 155


<210>  27233
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27233
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccuaugu gcugacggua caggccacau      120

uaggaucacc uaugugguau agugcagcau caaag                                 155


<210>  27234
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27234
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga uuacccaugu gcugacggua caggccacau      120

gaggauuacc caugugguau agugcagcau caaag                                 155


<210>  27235
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27235
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga uaacccaugu gcugacggua caggccacau      120

gaggauaacc caugugguau agugcagcau caaag                                 155


<210>  27236
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27236
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ugacccaugu gcugacggua caggccacau      120

gaggaugacc caugugguau agugcagcau caaag                                 155


<210>  27237
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27237
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ccacccaugu gcugacggua caggccacau      120

gaggaccacc caugugguau agugcagcau caaag                                 155


<210>  27238
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27238
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cagaugagga ucacccaugg gcugacggua caggccagau      120

gaggaucacc caugggguau agugcagcau caaag                                 155


<210>  27239
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  27239
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugggga ucacccaugu gcugacggua caggccacau      120

ggggaucacc caugugguau agugcagcau caaag                                 155


<210>  27240
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27240
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ucacccaugu gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  27241
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27241
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucaccu gaggaucacc caggugagca ucaaag                                 96


<210>  27242
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27242
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgcau gaggaucacc caugcgagca ucaaag                                 96


<210>  27243
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27243
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgccu gaggaucacc caggcgagca ucaaag                                 96


<210>  27244
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27244
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgccu gagcaucagc caggcgagca ucaaag                                 96


<210>  27245
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27245
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gagcaucagc caugugagca ucaaag                                 96


<210>  27246
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27246
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaguaucaac caugugagca ucaaag                                 96


<210>  27247
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27247
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gagaaucagc caugugagca ucaaag                                 96


<210>  27248
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27248
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuu gaggaucacc caugugagca ucaaag                                 96


<210>  27249
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27249
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacuu gaggaucacc caugugagca ucaaag                                 96


<210>  27250
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27250
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucaccu gaggaucacc caugugagca ucaaag                                 96


<210>  27251
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27251
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc uaugugagca ucaaag                                 96


<210>  27252
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27252
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc aaugugagca ucaaag                                 96


<210>  27253
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27253
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc gaugugagca ucaaag                                 96


<210>  27254
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27254
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc uaugugagca ucaaag                                 96


<210>  27255
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27255
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggauuacc caugugagca ucaaag                                 96


<210>  27256
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27256
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggauaacc caugugagca ucaaag                                 96


<210>  27257
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27257
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaugacc caugugagca ucaaag                                 96


<210>  27258
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27258
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaccacc caugugagca ucaaag                                 96


<210>  27259
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27259
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucagau gaggaucacc caugggagca ucaaag                                 96


<210>  27260
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27260
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau ggggaucacc caugugagca ucaaag                                 96


<210>  27261
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27261
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucagag                                 96


<210>  27262
<211>  145
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27262
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau gaggaucacc      120

caugugguau agugcagcau cagag                                            145


<210>  27263
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27263
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau cagag                                 155


<210>  27264
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27264
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag acauggcagu cguaacgacg cgggucugac gguacaggcc      120

acaugaggau cacccaugug guauagugca gcaucagag                             159


<210>  27265
<211>  145
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold variant

<400>  27265
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu auggggccac augaggauca cccauguggu guacagcgca gcgucaauga      120

cgcugacgau agugcagcau caaag                                            145


<210>  27266
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop

<400>  27266
ugggcgcagc gucaaugacg cugacgguac a                                      31


<210>  27267
<211>  66
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop

<400>  27267
gcacuauggg cgcagcguca augacgcuga cgguacaggc cagacaauua uugucuggua       60

uagugc                                                                  66


<210>  27268
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop

<400>  27268
gcugacggua caggc                                                        15


<210>  27269
<211>  167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop

<400>  27269
caggaagcac uaugggcgca gcgucaauga cgcugacggu acaggccaga caauuauugu       60

cugguauagu gcagcagcag aacaauuugc ugagggcuau ugaggcgcaa cagcaucugu      120

ugcaacucac agucuggggc aucaagcagc uccaggcaag aauccug                    167


<210>  27270
<211>  234
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop

<400>  27270
aggagcuuug uuccuugggu ucuugggagc agcaggaagc acuaugggcg cagcgucaau       60

gacgcugacg guacaggcca gacaauuauu gucugguaua gugcagcagc agaacaauuu      120

gcugagggcu auugaggcgc aacagcaucu guugcaacuc acagucuggg gcaucaagca      180

gcuccaggca agaauccugg cuguggaaag auaccuaaag gaucaacagc uccu            234

