                               SEQUENCE LISTING

<110> GENZYME CORPORATION
 
<120> TREATMENT OF HEMOPHILIA WITH FITUSIRAN

<130> 022548.WO086

<140>
<141>

<150> 63/275,344
<151> 2021-11-03

<150> 63/272,629
<151> 2021-10-27

<150> 63/121,973
<151> 2020-12-06

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoroguanosine

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluorouridine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyluridine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoroadenosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyladenosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-fluorocytidine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluorocytidine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyluridine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluorouridine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoroadenosine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methylcytidine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluorouridine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluorocytidine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-fluoroadenosine

<220>
<221> source
<223> /note="3' L96 GalNAc containing moiety"

<400> 1
gguuaacacc auuuacuuca a                                                 21


<210> 2
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyluridine

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methylguanosine

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine

<220>
<221> misc_feature
<222> (21)..(22)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine

<220>
<221> misc_feature
<222> (22)..(23)
<223> /note="phosphorothioate linkage"

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-O-methylguanosine

<400> 2
uugaaguaaa ugguguuaac cag                                               23


