                         SEQUENCE LISTING

<110>  ҩҵ޹˾
 
<120>  GPC3弰Ӧ

<130>  6A43-2103481IB

<150>  CN202011437242.9
<151>  2020-12-10

<150>  CN202111353420.4
<151>  2021-11-16

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  2
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Y035 VH

<400>  2

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  3
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Y035 VL

<400>  3

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ile Thr Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  4
<211>  475
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Y035 scFv-hFc

<400>  4

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ile Thr Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
145                 150                 155                 160 


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                165                 170                 175     


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
            180                 185                 190         


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ala Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  5
<211>  121
<212>  PRT
<213>  Artificial squence

<220>
<223>  T2-23 VH

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Arg Gly Ser His Ala Asp Ala Leu Asn Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T2-23 VL

<400>  6

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Gly Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  7
<211>  479
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T2-23 scFv-hFc

<400>  7

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Gly Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
                165                 170                 175     


Ile Ser Ser Ser Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val Glu Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asp Arg Arg Gly Ser His Ala Asp Ala Leu Asn Val Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ala Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  8
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human GPC3: Ala524-Lys563

<400>  8

Ala Glu Leu Ala Tyr Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser 
1               5                   10                  15      


Gln Gln Ala Thr Pro Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu 
            20                  25                  30          


Gly Asn Val His Ser Pro Leu Lys 
        35                  40  


<210>  9
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human GPC3:Asp511-Ser560

<400>  9

Asp Gly Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu 
1               5                   10                  15      


Ala Tyr Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala 
            20                  25                  30          


Thr Pro Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val 
        35                  40                  45              


His Ser 
    50  


<210>  10
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  11
<211>  580
<212>  PRT
<213>  Macaca fascicularis

<400>  11

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Val Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Met Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Val Pro Gly Asn Asn Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  12
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  foward primer

<400>  12
cttggtggtc ctggctgc                                                     18


<210>  13
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer

<400>  13
ggtacgtgct gttgaactgt tcc                                               23


<210>  14
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  forward sequnce

<400>  14

Cys Ala Thr Gly Cys Cys Ala Thr Gly Ala Cys Thr Gly Thr Gly Gly 
1               5                   10                  15      


Cys Cys Cys Ala Gly Gly Cys Gly Gly Cys Cys Cys Ala Gly Lys Thr 
            20                  25                  30          


Gly Cys Ala Gly Cys Thr Cys Gly Thr Gly Gly Ala Gly Thr Cys 
        35                  40                  45          


<210>  15
<211>  51
<212>  DNA
<213>  Artificial sequnce

<220>
<223>  reverse primer

<400>  15
catgccatga ctcgcggccg gcctggccat gggggtcttc gctgtggtgc g                51


<210>  16
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse sequence

<400>  16
catgccatga ctcgcggccg gcctggccgt cttgtggttt tggtgtcttg gg               52


<210>  17
<211>  123
<212>  PRT
<213>  Vicugna pacos

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Pro Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gly Pro Val Lys Arg Tyr Ser Thr Asp Phe Gln Gly Gly Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  18
<211>  122
<212>  PRT
<213>  Vicugna pacos

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Thr Tyr Thr 
            20                  25                  30          


Met Ala Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Glu Ser Val Ala 
        35                  40                  45              


Ala Ile Ser Ser Gly Gly Arg Thr Asp Tyr Ile Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser 
                85                  90                  95      


Ala Asp Gly Leu Lys Ile Gly Thr Tyr Tyr Phe Lys Gly Leu Gly Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ala 
        115                 120         


<210>  19
<211>  123
<212>  PRT
<213>  Vicugna pacos

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Asp Ile Ser Thr Tyr 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Thr Thr Gly Arg Ser Ile Tyr Ile Asp Ala Val Gln 
    50                  55                  60                  


Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ser Ala Asp Asp Leu Lys Ile Gly Thr Gln Tyr Phe Lys Gly Leu Gly 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  20
<211>  124
<212>  PRT
<213>  Vicugna pacos

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Arg Phe Ser Thr Asn 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Leu 
        35                  40                  45              


Ala Ala Ile Asn Trp Val Ile Gly Asn Thr Asn Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Glu Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Ser Ser Tyr Tyr Thr Ser Ser Arg Arg Glu Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  21
<211>  123
<212>  PRT
<213>  Vicugna pacos

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Gly Ser Gly Arg Ser Phe Gly Leu Arg 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Lys Ala Gly Asp Thr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Thr Ala Ala Arg Trp Glu Pro Pro Thr Ile Thr Pro Gly Ser Tyr 
            100                 105                 110         


Arg Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  22
<211>  121
<212>  PRT
<213>  Vicugna pacos

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Ser Ile Thr 
            20                  25                  30          


Ala Met Asn Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Asn Gly Gly Arg Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Gly Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Arg Arg Trp Thr Gly Gly Asp Arg Pro Glu Tyr Glu Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  123
<212>  PRT
<213>  Vicugna pacos

<400>  23

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Val Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Thr Ser Gly Asp Gly Ile Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Thr Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro Ile Pro Gly Arg Ile 
            100                 105                 110         


Gly Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  24

Gly Arg Ser Phe Ser Pro Tyr Ala 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  25

Ile Ser Asn Ser Gly Gly Ser Thr 
1               5               


<210>  26
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  26

Thr Gly Pro Val Lys Arg Tyr Ser Thr Asp Phe Gln Gly Gly Asp Tyr 
1               5                   10                  15      


<210>  27
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  27

Pro Tyr Ala Met Gly 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  28

Ala Ile Ser Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  29

Pro Val Lys Arg Tyr Ser Thr Asp Phe Gln Gly Gly Asp Tyr 
1               5                   10                  


<210>  30
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  30

Gly Arg Ser Phe Ser Pro Tyr 
1               5           


<210>  31
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  31

Ser Asn Ser Gly Gly Ser 
1               5       


<210>  32
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  32

Pro Val Lys Arg Tyr Ser Thr Asp Phe Gln Gly Gly Asp Tyr 
1               5                   10                  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  33

Gly Ser Ile Ser Thr Tyr Thr 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  34

Ile Ser Ser Gly Gly Arg Thr 
1               5           


<210>  35
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  35

Asn Ser Ala Asp Gly Leu Lys Ile Gly Thr Tyr Tyr Phe Lys Gly Leu 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  36

Tyr Thr Met Ala 
1               


<210>  37
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  37

Ala Ile Ser Ser Gly Gly Arg Thr Asp Tyr Ile Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  38
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  38

Ala Asp Gly Leu Lys Ile Gly Thr Tyr Tyr Phe Lys Gly Leu Gly 
1               5                   10                  15  


<210>  39
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GSISTY

<400>  39

Gly Ser Ile Ser Thr Tyr 
1               5       


<210>  40
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  40

Ser Ser Gly Gly Arg 
1               5   


<210>  41
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  41

Ala Asp Gly Leu Lys Ile Gly Thr Tyr Tyr Phe Lys Gly Leu Gly 
1               5                   10                  15  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  42

Gly Val Asp Ile Ser Thr Tyr Thr 
1               5               


<210>  43
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  43

Ile Ser Thr Thr Gly Arg Ser 
1               5           


<210>  44
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  44

Asn Ser Ala Asp Asp Leu Lys Ile Gly Thr Gln Tyr Phe Lys Gly Leu 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  45

Thr Tyr Thr Met Ala 
1               5   


<210>  46
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  46

Ala Ile Ser Thr Thr Gly Arg Ser Ile Tyr Ile Asp Ala Val Gln Gly 
1               5                   10                  15      


<210>  47
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  47

Ala Asp Asp Leu Lys Ile Gly Thr Gln Tyr Phe Lys Gly Leu Gly 
1               5                   10                  15  


<210>  48
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  48

Gly Val Asp Ile Ser Thr Tyr 
1               5           


<210>  49
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  49

Ser Thr Thr Gly Arg 
1               5   


<210>  50
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  50

Ala Asp Asp Leu Lys Ile Gly Thr Gln Tyr Phe Lys Gly Leu Gly 
1               5                   10                  15  


<210>  51
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  51

Gly Arg Arg Phe Ser Thr Asn Val 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  52

Ile Asn Trp Val Ile Gly Asn Thr 
1               5               


<210>  53
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  53

Ala Gly Arg Ser Ser Tyr Tyr Thr Ser Ser Arg Arg Glu Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  54
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  54

Thr Asn Val Met Gly 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  55

Ala Ile Asn Trp Val Ile Gly Asn Thr Asn Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  56

Arg Ser Ser Tyr Tyr Thr Ser Ser Arg Arg Glu Asp Tyr Asp Tyr 
1               5                   10                  15  


<210>  57
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  57

Gly Arg Arg Phe Ser Thr Asn 
1               5           


<210>  58
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  58

Asn Trp Val Ile Gly Asn 
1               5       


<210>  59
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  59

Arg Ser Ser Tyr Tyr Thr Ser Ser Arg Arg Glu Asp Tyr Asp Tyr 
1               5                   10                  15  


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  60

Gly Arg Ser Phe Gly Leu Arg Ala 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  61

Ile Gly Lys Ala Gly Asp Thr Thr 
1               5               


<210>  62
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  62

Ala Thr Ala Ala Arg Trp Glu Pro Pro Thr Ile Thr 
1               5                   10          


<210>  63
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  63

Leu Arg Ala Met Gly 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  64

Ala Ile Gly Lys Ala Gly Asp Thr Thr Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  65

Ala Ala Arg Trp Glu Pro Pro Thr Ile Thr Pro Gly Ser Tyr 
1               5                   10                  


<210>  66
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  66

Gly Arg Ser Phe Gly Leu Arg 
1               5           


<210>  67
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  67

Gly Lys Ala Gly Asp Thr 
1               5       


<210>  68
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  68

Ala Ala Arg Trp Glu Pro Pro Thr Ile Thr Pro Gly Ser Tyr 
1               5                   10                  


<210>  69
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  69

Gly Ser Ile Leu Ser Ile Thr Ala 
1               5               


<210>  70
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  70

Ile Thr Asn Gly Gly Arg Thr 
1               5           


<210>  71
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  71

Tyr Ala Arg Arg Trp Thr Gly Gly Asp Arg Pro Glu Tyr Glu Ser 
1               5                   10                  15  


<210>  72
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  72

Ile Thr Ala Met Asn 
1               5   


<210>  73
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  73

Ser Ile Thr Asn Gly Gly Arg Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  74
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  74

Arg Arg Trp Thr Gly Gly Asp Arg Pro Glu Tyr Glu Ser 
1               5                   10              


<210>  75
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  75

Gly Ser Ile Leu Ser Ile Thr 
1               5           


<210>  76
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  76

Thr Asn Gly Gly Arg 
1               5   


<210>  77
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  77

Arg Arg Trp Thr Gly Gly Asp Arg Pro Glu Tyr Glu Ser 
1               5                   10              


<210>  78
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  78

Gly Phe Thr Leu Asp Val Tyr Ala 
1               5               


<210>  79
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  79

Ile Thr Ser Gly Asp Gly Ile 
1               5           


<210>  80
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  80

Ala Thr Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro 
1               5                   10          


<210>  81
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  81

Val Tyr Ala Ile Gly 
1               5   


<210>  82
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  82

Tyr Ile Thr Ser Gly Asp Gly Ile Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  83
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  83

Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro Ile Pro Gly Arg Ile 
1               5                   10                  15  


<210>  84
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  84

Gly Phe Thr Leu Asp Val Tyr 
1               5           


<210>  85
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  85

Thr Ser Gly Asp Gly 
1               5   


<210>  86
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  86

Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro Ile Pro Gly Arg Ile 
1               5                   10                  15  


<210>  87
<211>  124
<212>  PRT
<213>  Vicugna pacos

<400>  87

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Glu Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Thr Gly Gly Thr Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro Lys Pro Gly Arg 
            100                 105                 110         


Ile Gly Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  88
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  88

Gly Phe Thr Leu Glu Asn Tyr Ala 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  89

Ile Thr Gly Gly Thr Gly Thr Thr 
1               5               


<210>  90
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  90

Ala Thr Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro 
1               5                   10          


<210>  91
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  91

Asn Tyr Ala Ile Gly 
1               5   


<210>  92
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  92

Tyr Ile Thr Gly Gly Thr Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  93

Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro Lys Pro Gly Arg Ile 
1               5                   10                  15  


<210>  94
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  94

Gly Phe Thr Leu Glu Asn Tyr 
1               5           


<210>  95
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  95

Thr Gly Gly Thr Gly Thr 
1               5       


<210>  96
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  96

Leu Lys Arg Thr Thr Ala Gly Gly Trp Pro Lys Pro Gly Arg Ile 
1               5                   10                  15  


