                            б

<110>  㽭ҩ޹˾
             ҩ޹˾
 
<120>  SIRP弰;

<130>  DSP1P213292Z

<150>  CN 202011464010.2
<151>  2020-12-11

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  #4 VH

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Arg Gly Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Lys Gly Pro Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  2
<211>  339
<212>  DNA
<213>  artificial sequence

<220>
<223>  #4 VH DNA

<400>  2
gaggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgccac cgtgaagatc       60

tcctgccgcg gctccggctt caacatcaag gactactaca tccagtgggt gcagcaggcc      120

cccggcaagg gcctggagtg gatgggctgg atcgaccccg agaacggcga caccaagtac      180

gcccccaagt tccagggccg cgtgaccatc accgccgaca cctccaccga caccgcctac      240

atggagctgt cctccctgcg ctccgaggac accgccgtgt actactgcta cgccaagggc      300

ccctactggg gccagggcac caccctgacc gtctcgagc                             339


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #4 VH-CDR1

<400>  3

Asp Tyr Tyr Ile Gln 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #4 VH-CDR2

<400>  4

Trp Ile Asp Pro Glu Asn Gly Asp Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #4 VH-CDR3

<400>  5

Lys Gly Pro Tyr 
1               


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #4 VL

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  #4 VL DNA

<400>  7
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ccctgggcga gcgcgccacc       60

atcaactgca agtcctccca gtccctgttc tactcctcca accagaagaa cttcctggcc      120

tggtaccagc agaagcccgg ccagcccccc aagctgctga tctactgggc ctccacccgc      180

gagtccggcg tgcccgaccg cttcaccggc tccggctccg gcaccgactt caccctgacc      240

atctcctccg tgaaggccga ggacctggcc gtgtactact gccagcagta ctactcctac      300

ccccccacct tcggcggcgg caccaagctc gagataaaa                             339


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #4 VL-CDR1

<400>  8

Lys Ser Ser Gln Ser Leu Phe Tyr Ser Ser Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #4 VL-CDR2

<400>  9

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #4 VL-CDR3

<400>  10

Gln Gln Tyr Tyr Ser Tyr Pro Pro Thr 
1               5                   


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VH

<400>  11

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser His 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Thr Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Asn Tyr His Tyr Asn Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  12
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  #11 VH DNA

<400>  12
caggtgaccc tgaaggagtc cggccccgtg ctggtgaagc ccaccgagac cctgaccctg       60

acctgcaccg tgtccggctt ctccctgtcc tcccacggcg tgcactggat ccgccagccc      120

cccggcaagg ccctggagtg gctggccgtg atctggtccg acggctccac cacctacaac      180

tccaccctga agtcccgcct gaccatctcc aaggacacct ccaagtccca ggtggtgctg      240

accatgacca acatggaccc cgtggacacc gccacctact actgcgcccg ccacggcaac      300

taccactaca acatggacta ctggggccag ggcaccctgg tgaccgtctc gagc            354


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VH-CDR1

<400>  13

Ser His Gly Val His 
1               5   


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VH-CDR2

<400>  14

Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Thr Leu Lys Ser 
1               5                   10                  15      


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VH-CDR3

<400>  15

His Gly Asn Tyr His Tyr Asn Met Asp Tyr 
1               5                   10  


<210>  16
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VL

<400>  16

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Ser Arg Val Asn Ser Gly 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  17
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  #11 VL DNA

<400>  17
gacatccagc tgacccagtc cccctccttc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgcc gcacctcctc ccgcgtgaac tccggctacc tgcactggta ccagcagaag      120

cccggcaagg cccccaagct gctgatctac tccacctcca ccctggcctc cggcgtgccc      180

tcccgcttct ccggctccgg ctccggcacc gagttcaccc tgaccatctc ctccctgcag      240

cccgaggact tcgccaccta ctactgccag cagtactcct cctacccctg gaccttcggc      300

ggcggcacca agctcgagat aaaa                                             324


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VL-CDR1

<400>  18

Arg Thr Ser Ser Arg Val Asn Ser Gly Tyr Leu His 
1               5                   10          


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VL-CDR2

<400>  19

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #11 VL-CDR3

<400>  20

Gln Gln Tyr Ser Ser Tyr Pro Trp Thr 
1               5                   


<210>  21
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VH

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Gly Pro Leu Tyr Arg Tyr Asp Gly Tyr Gly Leu Glu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  22
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  #13 VH DNA

<400>  22
caggtgcagc tggtgcagtc cggctccgag ctgaagaagc ccggcgcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc gactactcca tccactgggt gcgccaggcc      120

cccggccagg gcctggagtg gatgggctgg atcaacaccg agaccggcga gcccacctac      180

gccgacgact tcaagggccg cttcgtgttc tccctggaca cctccgtgtc caccgcctac      240

ctgcagatct gctccctgaa ggccgaggac accgccgtgt actactgctc ccgcggcccc      300

ctgtaccgct acgacggcta cggcctggag tactggggcc agggcaccct ggtgaccgtc      360

tcgagc                                                                 366


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VH-CDR1

<400>  23

Asp Tyr Ser Ile His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VH-CDR2

<400>  24

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VH-CDR3

<400>  25

Gly Pro Leu Tyr Arg Tyr Asp Gly Tyr Gly Leu Glu Tyr 
1               5                   10              


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VL

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Cys Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Asp Tyr Ile Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  #13 VL DNA

<400>  27
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ccctgggcga gcgcgccacc       60

atcaactgca aggcctccca gtccgtgtcc aacgacgtgg cctggtacca gcagaagccc      120

ggccagcccc ccaagctgct gatctactac gcctccaacc gctgcaccgg cgtgcccgac      180

cgcttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcaggcc      240

gaggacgtgg ccgtgtacta ctgccaccag gactacatct ccccctacac cttcggcggc      300

ggcaccaagc tcgagataaa a                                                321


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VL-CDR1

<400>  28

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VL-CDR2

<400>  29

Tyr Ala Ser Asn Arg Cys Thr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #13 VL-CDR3

<400>  30

His Gln Asp Tyr Ile Ser Pro Tyr Thr 
1               5                   


<210>  31
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VH

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Asp Gly Ser Arg Tyr Asn Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Tyr Ala Asn Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  32
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  #14 VH DNA

<400>  32
caggtgcagc tgcaggagag cggaccagga ctggtgaagc ctagccagac actgtctctg       60

acctgcacag tgagcggcgg ctctatctcc agcggctact attggtcttg gatcagacag      120

cacccaggca agggcctgga gtggatcggc tacatctcct atgatggcag caggtataac      180

aatccttccc tgaagaaccg ggtgaccatc tctgtggaca catccaagaa tcagttcagc      240

ctgaagctgt cttccgtgac cgccgctgat acagccgtgt actattgcgc tcgcgaggag      300

tacgccaact atttcgctta ctggggccag ggcaccacag tgaccgtgag ctct            354


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VH-CDR1

<400>  33

Ser Gly Tyr Tyr Trp Ser 
1               5       


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VH-CDR2

<400>  34

Tyr Ile Ser Tyr Asp Gly Ser Arg Tyr Asn Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VH-CDR3

<400>  35

Glu Glu Tyr Ala Asn Tyr Phe Ala Tyr 
1               5                   


<210>  36
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VL

<400>  36

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  37
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  #14 VL DNA

<400>  37
gatatcgtga tgacccagtc tcctgactcc ctggccgtga gcctgggcga gagagctaca       60

atcaactgta agtccagcca gtctctgttc tactcttcca accagaagaa ttttctggcc      120

tggtatcagc agaagcccgg ccagccccct aagctgctga tctactgggc tagcaccaga      180

gagtctggag tgcctgaccg cttcaccgga tccggaagcg gaacagactt caccctgaca      240

atcagctctg tgaaggccga ggatctggcc gtgtactatt gccagcagta ctattcttat      300

ccacccacct tcggccaggg cacaaagctc gagatcaag                             339


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VL-CDR1

<400>  38

Lys Ser Ser Gln Ser Leu Phe Tyr Ser Ser Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VL-CDR2

<400>  39

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 VL-CDR3

<400>  40

Gln Gln Tyr Tyr Ser Tyr Pro Pro Thr 
1               5                   


<210>  41
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 HC

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Asp Gly Ser Arg Tyr Asn Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Tyr Ala Asn Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  42
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  #14 LC

<400>  42

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


