<110>    HK INNO.N CORPORATION
         Y-BIOLOGICS INC.

<120>    Anti-OX40L antibody, anti-OX40L and anti-TNFa bispecific
         antibody, and uses thereof

<130>    P20-099-HKI

<160>    94

<170>    KoPatentIn 3.0

<210>    1
<211>    183
<212>    PRT
<213>    Unknown

<220>
<223>    OX40L seq


<400>    1
Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg
  1               5                  10                  15 

Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln
             20                  25                  30 

Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser
         35                  40                  45 

Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val
     50                  55                  60 

Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln
 65                  70                  75                  80 

Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn
                 85                  90                  95 

Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu
            100                 105                 110 

Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln
        115                 120                 125 

Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr
    130                 135                 140 

Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu
145                 150                 155                 160 

Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn
                165                 170                 175 

Pro Gly Glu Phe Cys Val Leu
            180            


<210>    2
<211>    139
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    OX40L-his


<400>    2
His His His His His His Gln Val Ser His Arg Tyr Pro Arg Ile Gln
  1               5                  10                  15 

Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile
             20                  25                  30 

Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser
         35                  40                  45 

Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr
     50                  55                  60 

Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu
 65                  70                  75                  80 

Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val
                 85                  90                  95 

Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp
            100                 105                 110 

Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu
        115                 120                 125 

Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu
    130                 135                


<210>    3
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    epitope 93-100


<400>    3
Val Ile Ile Asn Cys Asp Gly Phe
  1               5            


<210>    4
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    epitope 141-151


<400>    4
Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu
  1               5                  10    


<210>    5
<211>    330
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IgG1 HC


<400>    5
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
  1               5                  10                  15 

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
             20                  25                  30 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
         35                  40                  45 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
     50                  55                  60 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
 65                  70                  75                  80 

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                 85                  90                  95 

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110 

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125 

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175 

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205 

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 

Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255 

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270 

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285 

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330


<210>    6
<211>    330
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IgG1 HC N297A


<400>    6
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
  1               5                  10                  15 

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
             20                  25                  30 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
         35                  40                  45 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
     50                  55                  60 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
 65                  70                  75                  80 

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                 85                  90                  95 

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110 

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125 

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175 

Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205 

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 

Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255 

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270 

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285 

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330


<210>    7
<211>    327
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IgG4 HC


<400>    7
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
  1               5                  10                  15 

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
             20                  25                  30 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
         35                  40                  45 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
     50                  55                  60 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
 65                  70                  75                  80 

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                 85                  90                  95 

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110 

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125 

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140 

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175 

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190 

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205 

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255 

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270 

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285 

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 

Leu Ser Leu Ser Leu Gly Lys
                325        


<210>    8
<211>    327
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IgG4 HC S228P


<400>    8
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
  1               5                  10                  15 

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
             20                  25                  30 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
         35                  40                  45 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
     50                  55                  60 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
 65                  70                  75                  80 

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                 85                  90                  95 

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110 

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125 

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140 

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175 

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190 

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205 

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255 

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270 

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285 

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 

Leu Ser Leu Ser Leu Gly Lys
                325        


<210>    9
<211>    981
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IgG4 HC S228P


<400>    9
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag         60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg        120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca        180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc        240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc        300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc        360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg        420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat        480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac        540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag        600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa        660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag        720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag        780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc        840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg        900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc        960

ctctccctgt ctctgggtaa a                                                  981


<210>    10
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IgG LC


<400>    10
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
  1               5                  10                  15 

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
             20                  25                  30 

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
         35                  40                  45 

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
     50                  55                  60 

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
 65                  70                  75                  80 

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                 85                  90                  95 

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105        


<210>    11
<211>    321
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IgG LC


<400>    11
cgtacggtgg cggcgccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct         60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag        120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac        180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag        240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag        300

agcttcaaca ggggagagtg t                                                  321


<210>    12
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR1


<400>    12
Tyr Ala Trp Met Ser
  1               5


<210>    13
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR1


<400>    13
Asp Tyr Trp Met His
  1               5


<210>    14
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR1


<400>    14
Asn Tyr Trp Met Gln
  1               5


<210>    15
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR2


<400>    15
Arg Ile Lys Gly Glu Pro Asp Gly Gly Thr Thr Glu Tyr Ala Asp Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    16
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR2


<400>    16
Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys
  1               5                  10                  15 

Ser
   


<210>    17
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR2


<400>    17
Glu Ile Asp Pro Gly Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys
  1               5                  10                  15 

Asn
   


<210>    18
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR2


<400>    18
Glu Ile Asp Pro Ser Asp Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys
  1               5                  10                  15 

Asn
   


<210>    19
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR3


<400>    19
Arg Arg Gly Leu Asp Val
  1               5    


<210>    20
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR3


<400>    20
Gly Ile Tyr Tyr Val Asp Tyr
  1               5        


<210>    21
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR3


<400>    21
Glu Gly Ala Gly Arg Gly Phe Pro Tyr
  1               5                


<210>    22
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VH CDR3


<400>    22
Glu Val Ser Leu Arg Ser Met Asp Tyr
  1               5                


<210>    23
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR1


<400>    23
Arg Ala Ser Gln Ser Ile Gly Arg Trp Leu Ala
  1               5                  10    


<210>    24
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR1


<400>    24
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His
  1               5                  10                  15 



<210>    25
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR2


<400>    25
Lys Ala Thr Ile Leu Glu Ser
  1               5        


<210>    26
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR2


<400>    26
Lys Val Ser Asn Arg Phe Ser
  1               5        


<210>    27
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR3


<400>    27
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr
  1               5                


<210>    28
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR3


<400>    28
Ser Gln Ser Thr His Val Pro Pro Thr
  1               5                


<210>    29
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR3


<400>    29
Ser Gln Ser Thr His Val Pro Trp Thr
  1               5                


<210>    30
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Anti-OX40L antibody VL CDR3


<400>    30
Ser Gln Ser Thr His Val Pro Phe Thr
  1               5                


<210>    31
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    linker 1


<400>    31
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
  1               5                  10                  15


<210>    32
<211>    20
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    linker 2


<400>    32
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
  1               5                  10                  15 

Gly Gly Gly Ser
             20


<210>    33
<211>    120
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Oxelumab VH


<400>    33
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ile Ile Ser Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Thr Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Arg Leu Val Ala Pro Gly Thr Phe Asp Tyr Trp Gly Gln
            100                 105                 110 

Gly Ala Leu Val Thr Val Ser Ser
        115                 120


<210>    34
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Oxelumab VL


<400>    34
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105        


<210>    35
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VH


<400>    35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
     50                  55                  60 

Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    36
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VL


<400>    36
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105        


<210>    37
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    02C09 VH


<400>    37
Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Tyr Ala
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Gly Arg Ile Lys Gly Glu Pro Asp Gly Gly Thr Thr Glu Tyr Ala Asp
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
 65                  70                  75                  80 

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Val Ser Arg Arg Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    38
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    02C09 VL


<400>    38
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Arg Trp
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Lys Ala Thr Ile Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Glu Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Asp Asp Phe Ser Ala Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105        


<210>    39
<211>    351
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    02C09 VH


<400>    39
caaatgcagc ttgttcaatc cggcggaggc ctggttaagc ctggcggatc tctgagagtg         60

tcttgtgccg ccagcggctt caccttcaat tacgcctgga tgagctgggt ccgacaggcc        120

cctggaaaag gactggaatg ggtcggaaga atcaagggcg agcctgatgg cggaaccaca        180

gagtacgccg atagcgtgaa gggcagattc accatcagcc gggacaacag caagaacacc        240

ctgtacctgc agatgaactc cctgagagcc gaggacacag ccgtgtacta ctgtgtgtct        300

agaagaggcc tggatgtgtg gggccaggga acaacagtga cagtttcttc t                 351


<210>    40
<211>    321
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    02C09 VL


<400>    40
gatatccaga tgacacagag ccctagcagc ctgtctgcct ctctgggcga tagagtgacc         60

atcacatgtc gggccagcca gtctattgga cggtggctgg cctggtatca gcaaaagcct        120

ggaaacgccc ctaagctgct gatctacaag gccaccatcc tggaaagcgg agtgccttct        180

agattttctg gcagcggctc tggcaccgag tttgccctga caattagctc cctgcagcct        240

gacgacttca gcgcctacta ctgccagcag tacaacagct acccctacac cttcggccag        300

ggcacaaagc tggaaatcaa g                                                  321


<210>    41
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu3F07 VH


<400>    41
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Pro Asp Tyr
             20                  25                  30 

Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    42
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu3F07 VL


<400>    42
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
             20                  25                  30 

Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                 85                  90                  95 

Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110 




<210>    43
<211>    348
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu3F07 VH


<400>    43
caagttcaac tggttcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg         60

tcctgcaagg cctctggctt cacattcccc gactactgga tgcactgggt tcgacaggct        120

ccaggacagg gactcgaatg gatgggcgag atcgatcctc ctaacggccg gaccaactac        180

aacgagaagt tcaagagcag agtgaccatg accagagaca ccagcatcag caccgcctac        240

atggaactga gcagactgag aagcgacgac accgccgtgt actactgtgc cagaggcatc        300

tactacgtgg actactgggg ccagggcacc acagtgacag ttagctct                     348


<210>    44
<211>    336
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu3F07 VL


<400>    44
gatatcgtga tgacacagag ccctctgagc ctgcctgtga cactgggaga acctgccagc         60

atcagctgta gaagcagcca gagcctggtg cacagcaacg gcaataccta cctgcactgg        120

tatctgcaga agcccggaca gtctccccag ctgctgatct acaaggtgtc caacagattc        180

agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatt        240

agcagagtgg aagccgagga cgtgggcgtg tactactgta gccagtctac ccacgtgcca        300

cctacctttg gcggcggaac aaagctggaa atcaag                                  336


<210>    45
<211>    118
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    10H07 VH


<400>    45
Gln Val Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
             20                  25                  30 

Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Glu Ile Asp Pro Gly Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Asn Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Asn Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys
                 85                  90                  95 

Ala Ser Glu Gly Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr
            100                 105                 110 

Leu Val Thr Val Ser Ala
        115            


<210>    46
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    10H07 VL


<400>    46
Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
  1               5                  10                  15 

Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
             20                  25                  30 

Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                 85                  90                  95 

Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110 




<210>    47
<211>    354
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    10H07 VH


<400>    47
caggtttatc tacagcagtc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg         60

tcctgcaagg cttctggcta caccttcacc gactactgga tgcactgggt gaagcagagg        120

cctggacaag gccttgagtg gattggagag attgatcctg gcaacggtcg tactaactac        180

aatgagaagt tcaagaacaa ggccacactg agtgtagaca aatcctccaa tacagcctac        240

atgcaattca gcagcctgac atctgaggac tctgcggtct tttactgtgc aagcgaggga        300

gctggacgtg gatttcctta ctggggccaa gggactctgg tcactgtctc cgca              354


<210>    48
<211>    336
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    10H07 VL


<400>    48
gatgttgtgc tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc         60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg        120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt        180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc        240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg        300

tggacgttcg gtggaggcac caagctggaa atcaaa                                  336


<210>    49
<211>    118
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    21G07 VH


<400>    49
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
             20                  25                  30 

Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Glu Ile Asp Pro Ser Asp Gly Arg Thr Asn Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Asn Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Ile Lys Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Val Ser Leu Arg Ser Met Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110 

Ser Val Thr Val Ser Ser
        115            


<210>    50
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    21G07 VL


<400>    50
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
  1               5                  10                  15 

Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
             20                  25                  30 

Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                 85                  90                  95 

Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110 




<210>    51
<211>    354
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    21G07 VH


<400>    51
caggtccaac tgcagcagtc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg         60

tcctgcaagg cttctggcta caccttcacc aactactgga tgcaatgggt gaaacagagg        120

cccggacaag gccttgagtg gattggagag attgatccta gcgacggtcg tactaactac        180

aatgagaagt tcaagaacaa ggccacactg actgtagaca gatcctccag cacagcctac        240

ataaaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagagaggtt        300

tcactacggt caatggacta ctggggccaa gggacctcag tcaccgtctc ctca              354


<210>    52
<211>    336
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    21G07 VL


<400>    52
gacattgttc tcacccagtc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc         60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg        120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt        180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc        240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcca        300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                  336


<210>    53
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    I3F07 VH


<400>    53
Gln Ile Gln Leu Ala Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Pro Asp Tyr
             20                  25                  30 

Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Ser Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Asn Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    54
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    I3F07 VL


<400>    54
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
  1               5                  10                  15 

Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
             20                  25                  30 

Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                 85                  90                  95 

Thr His Val Pro Pro Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys
            100                 105                 110 




<210>    55
<211>    348
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    I3F07 VH


<400>    55
cagattcagc tggctcagtc tggcgccgaa cttgtgaaac ctggcgcctc tgtgaagctg         60

agctgcaagg ccagcggctt cacctttcct gactactgga tgcactgggt caagcagagg        120

cctggacagg gactcgaatg gatcggcgag atcgatcctc ctaacggccg gaccaactac        180

aacgagaagt tcaagagcaa ggccacactg accgtggaca gcagcagcaa taccgcctac        240

atgcagctga gcagactgac ctctgaggac agcgccgtgt actactgtgc cagaggcatc        300

tactacgtgg actactgggg ccagggcaca accctgacag tttcttct                     348


<210>    56
<211>    336
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    I3F07 VL


<400>    56
gatatcgtgc tgacacagag ccctctgagc ctgcctgttt ctctgggaga tcaggccagc         60

atcagctgca gatcctctca gagcctggtg cacagcaacg gcaataccta cctgcactgg        120

tatctgcaga agcccggcca gtctcctaag ctgctgatct acaaggtgtc caacaggttc        180

agcggcgtgc ccgatagatt ttctggctct ggcagcggca ccgacttcac cctgaagatt        240

tctagagtgg aagccgagga cctgggcgtg tacttctgtt ctcagtctac ccacgtgcca        300

cctacctttg gcggcggaag caagctggaa atcaag                                  336


<210>    57
<211>    707
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    02C09-TNFai HC heavy chain


<400>    57
Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Tyr Ala
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Gly Arg Ile Lys Gly Glu Pro Asp Gly Gly Thr Thr Glu Tyr Ala Asp
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
 65                  70                  75                  80 

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Val Ser Arg Arg Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
        115                 120                 125 

Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys
    130                 135                 140 

Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
145                 150                 155                 160 

Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
                165                 170                 175 

Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
            180                 185                 190 

Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn
        195                 200                 205 

Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro
    210                 215                 220 

Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe
225                 230                 235                 240 

Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
                245                 250                 255 

Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe
            260                 265                 270 

Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
        275                 280                 285 

Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
    290                 295                 300 

Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
305                 310                 315                 320 

Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
                325                 330                 335 

Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
            340                 345                 350 

Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
        355                 360                 365 

Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
    370                 375                 380 

Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
385                 390                 395                 400 

Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu
                405                 410                 415 

Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
            420                 425                 430 

Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly
        435                 440                 445 

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val
    450                 455                 460 

Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser
465                 470                 475                 480 

Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val
                485                 490                 495 

Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Thr Trp
            500                 505                 510 

Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr
        515                 520                 525 

Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser
    530                 535                 540 

Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr
545                 550                 555                 560 

Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
                565                 570                 575 

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
            580                 585                 590 

Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro
        595                 600                 605 

Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
    610                 615                 620 

Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
625                 630                 635                 640 

Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser
                645                 650                 655 

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
            660                 665                 670 

Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys
        675                 680                 685 

Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val
    690                 695                 700 

Glu Ile Lys
705        


<210>    58
<211>    2121
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    02C09-TNFai HC heavy chain


<400>    58
caaatgcagc ttgttcaatc cggcggaggc ctggttaagc ctggcggatc tctgagagtg         60

tcttgtgccg ccagcggctt caccttcaat tacgcctgga tgagctgggt ccgacaggcc        120

cctggaaaag gactggaatg ggtcggaaga atcaagggcg agcctgatgg cggaaccaca        180

gagtacgccg atagcgtgaa gggcagattc accatcagcc gggacaacag caagaacacc        240

ctgtacctgc agatgaactc cctgagagcc gaggacacag ccgtgtacta ctgtgtgtct        300

agaagaggcc tggatgtgtg gggccaggga acaacagtga cagtttcttc tgcttccacc        360

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc        420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca        480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac        540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc        600

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt        660

cccccatgcc caccatgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc        720

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg        780

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag        840

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc        900

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc        960

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc       1020

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc       1080

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc       1140

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc       1200

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc       1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg       1320

tctctgggta aaggtggtgg cggatctggc ggcggaggaa gcggaggcgg aggctccgaa       1380

gtgcaactgg ttgaatctgg cggaggactg gtgcagcctg gaagaagcct gagactgtct       1440

tgtgccgcca gcggcttcac cttcgatgat tatgccatgc actgggtccg acaggcccct       1500

ggaaaaggac ttgaatgggt gtccgccatc acctggaaca gcggccacat cgattacgcc       1560

gatagcgtgg aaggccggtt caccatcagc agagacaacg ccaagaacag cctgtacctg       1620

cagatgaact ccctgagagc cgaggacacc gccgtgtact actgtgccaa agtgtcttac       1680

ctgagcaccg cctccagcct ggattattgg ggacagggca cactggtcac agtgtcctct       1740

ggtggcggag gttctggcgg aggtggtagt ggtggcggtg gaagtggtgg cggcggatct       1800

gatatccaga tgacacagag ccctagcagc ctgtctgcct ctgtgggcga tagagtgacc       1860

atcacctgta gagccagcca gggcatcaga aactacctgg cctggtatca gcagaagccc       1920

ggaaaggccc ctaagctgct gatctatgcc gcctctacac tgcagagcgg cgtgccatct       1980

agattttctg gcagcggctc tggcaccgac ttcaccctga caatttctag cctgcagcct       2040

gaggacgtgg ccacctacta ctgccagaga tacaacagag ccccttacac cttcggccag       2100

ggcaccaagg tggaaatcaa g                                                 2121


<210>    59
<211>    477
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    02C09-TNFai LC light chain


<400>    59
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Arg Trp
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Lys Ala Thr Ile Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Glu Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Asp Asp Phe Ser Ala Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
225                 230                 235                 240 

Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                245                 250                 255 

Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys
            260                 265                 270 

Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp
        275                 280                 285 

Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
    290                 295                 300 

Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
305                 310                 315                 320 

Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser
                325                 330                 335 

Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
            340                 345                 350 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
        355                 360                 365 

Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
    370                 375                 380 

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg
385                 390                 395                 400 

Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                405                 410                 415 

Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe
            420                 425                 430 

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
        435                 440                 445 

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala
    450                 455                 460 

Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
465                 470                 475        


<210>    60
<211>    1431
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    02C09-TNFai LC light chain


<400>    60
gatatccaga tgacacagag ccctagcagc ctgtctgcct ctctgggcga tagagtgacc         60

atcacatgtc gggccagcca gtctattgga cggtggctgg cctggtatca gcaaaagcct        120

ggaaacgccc ctaagctgct gatctacaag gccaccatcc tggaaagcgg agtgccttct        180

agattttctg gcagcggctc tggcaccgag tttgccctga caattagctc cctgcagcct        240

gacgacttca gcgcctacta ctgccagcag tacaacagct acccctacac cttcggccag        300

ggcacaaagc tggaaatcaa gcgtacggtg gcggcgccat ctgtcttcat cttcccgcca        360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat        420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag        480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg        540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc        600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggtggtgg cggatctggc        660

ggcggaggaa gcggaggcgg aggctccgaa gtgcaactgg ttgaatctgg cggaggactg        720

gtgcagcctg gaagaagcct gagactgtct tgtgccgcca gcggcttcac cttcgatgat        780

tatgccatgc actgggtccg acaggcccct ggaaaaggac ttgaatgggt gtccgccatc        840

acctggaaca gcggccacat cgattacgcc gatagcgtgg aaggccggtt caccatcagc        900

agagacaacg ccaagaacag cctgtacctg cagatgaact ccctgagagc cgaggacacc        960

gccgtgtact actgtgccaa agtgtcttac ctgagcaccg cctccagcct ggattattgg       1020

ggacagggca cactggtcac agtgtcctct ggtggcggag gttctggcgg aggtggtagt       1080

ggtggcggtg gaagtggtgg cggcggatct gatatccaga tgacacagag ccctagcagc       1140

ctgtctgcct ctgtgggcga tagagtgacc atcacctgta gagccagcca gggcatcaga       1200

aactacctgg cctggtatca gcagaagccc ggaaaggccc ctaagctgct gatctatgcc       1260

gcctctacac tgcagagcgg cgtgccatct agattttctg gcagcggctc tggcaccgac       1320

ttcaccctga caatttctag cctgcagcct gaggacgtgg ccacctacta ctgccagaga       1380

tacaacagag ccccttacac cttcggccag ggcaccaagg tggaaatcaa g                1431


<210>    61
<211>    706
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Hu3F07-TNFai HC heavy chain


<400>    61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Pro Asp Tyr
             20                  25                  30 

Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr Val
            100                 105                 110 

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125 

Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175 

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
            180                 185                 190 

Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr
        195                 200                 205 

Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro
    210                 215                 220 

Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
225                 230                 235                 240 

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                245                 250                 255 

Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
            260                 265                 270 

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
        275                 280                 285 

Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
    290                 295                 300 

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
305                 310                 315                 320 

Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
                325                 330                 335 

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
            340                 345                 350 

Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
        355                 360                 365 

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
    370                 375                 380 

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
385                 390                 395                 400 

Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
                405                 410                 415 

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
            420                 425                 430 

Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser
        435                 440                 445 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
    450                 455                 460 

Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys
465                 470                 475                 480 

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg
                485                 490                 495 

Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn
            500                 505                 510 

Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile
        515                 520                 525 

Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
    530                 535                 540 

Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu
545                 550                 555                 560 

Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                565                 570                 575 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            580                 585                 590 

Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
        595                 600                 605 

Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
    610                 615                 620 

Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
625                 630                 635                 640 

Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly
                645                 650                 655 

Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
            660                 665                 670 

Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln
        675                 680                 685 

Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu
    690                 695                 700 

Ile Lys
705    


<210>    62
<211>    2118
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hu3F07-TNFai HC heavy chain


<400>    62
caagttcaac tggttcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg         60

tcctgcaagg cctctggctt cacattcccc gactactgga tgcactgggt tcgacaggct        120

ccaggacagg gactcgaatg gatgggcgag atcgatcctc ctaacggccg gaccaactac        180

aacgagaagt tcaagagcag agtgaccatg accagagaca ccagcatcag caccgcctac        240

atggaactga gcagactgag aagcgacgac accgccgtgt actactgtgc cagaggcatc        300

tactacgtgg actactgggg ccagggcacc acagtgacag ttagctctgc ttccaccaag        360

ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc        420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc        480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc        540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaac        600

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttgagtccaa atatggtccc        660

ccatgcccac catgcccagc acctgagttc ctggggggac catcagtctt cctgttcccc        720

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg        780

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg        840

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc        900

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc        960

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga       1020

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc       1080

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat       1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc       1200

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca       1260

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct       1320

ctgggtaaag gtggtggcgg atctggcggc ggaggaagcg gaggcggagg ctccgaagtg       1380

caactggttg aatctggcgg aggactggtg cagcctggaa gaagcctgag actgtcttgt       1440

gccgccagcg gcttcacctt cgatgattat gccatgcact gggtccgaca ggcccctgga       1500

aaaggacttg aatgggtgtc cgccatcacc tggaacagcg gccacatcga ttacgccgat       1560

agcgtggaag gccggttcac catcagcaga gacaacgcca agaacagcct gtacctgcag       1620

atgaactccc tgagagccga ggacaccgcc gtgtactact gtgccaaagt gtcttacctg       1680

agcaccgcct ccagcctgga ttattgggga cagggcacac tggtcacagt gtcctctggt       1740

ggcggaggtt ctggcggagg tggtagtggt ggcggtggaa gtggtggcgg cggatctgat       1800

atccagatga cacagagccc tagcagcctg tctgcctctg tgggcgatag agtgaccatc       1860

acctgtagag ccagccaggg catcagaaac tacctggcct ggtatcagca gaagcccgga       1920

aaggccccta agctgctgat ctatgccgcc tctacactgc agagcggcgt gccatctaga       1980

ttttctggca gcggctctgg caccgacttc accctgacaa tttctagcct gcagcctgag       2040

gacgtggcca cctactactg ccagagatac aacagagccc cttacacctt cggccagggc       2100

accaaggtgg aaatcaag                                                     2118


<210>    63
<211>    482
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Hu3F07-TNFai LC light chain


<400>    63
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
             20                  25                  30 

Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                 85                  90                  95 

Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110 

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125 

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140 

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175 

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190 

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205 

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
225                 230                 235                 240 

Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys
                245                 250                 255 

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg
            260                 265                 270 

Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn
        275                 280                 285 

Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile
    290                 295                 300 

Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
305                 310                 315                 320 

Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu
                325                 330                 335 

Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            340                 345                 350 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
        355                 360                 365 

Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
    370                 375                 380 

Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
385                 390                 395                 400 

Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                405                 410                 415 

Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly
            420                 425                 430 

Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
        435                 440                 445 

Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln
    450                 455                 460 

Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu
465                 470                 475                 480 

Ile Lys
       


<210>    64
<211>    1446
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hu3F07-TNFai LC light chain


<400>    64
gatatcgtga tgacacagag ccctctgagc ctgcctgtga cactgggaga acctgccagc         60

atcagctgta gaagcagcca gagcctggtg cacagcaacg gcaataccta cctgcactgg        120

tatctgcaga agcccggaca gtctccccag ctgctgatct acaaggtgtc caacagattc        180

agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatt        240

agcagagtgg aagccgagga cgtgggcgtg tactactgta gccagtctac ccacgtgcca        300

cctacctttg gcggcggaac aaagctggaa atcaagcgta cggtggcggc gccatctgtc        360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg        420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa        480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc        540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa        600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtggt        660

ggtggcggat ctggcggcgg aggaagcgga ggcggaggct ccgaagtgca actggttgaa        720

tctggcggag gactggtgca gcctggaaga agcctgagac tgtcttgtgc cgccagcggc        780

ttcaccttcg atgattatgc catgcactgg gtccgacagg cccctggaaa aggacttgaa        840

tgggtgtccg ccatcacctg gaacagcggc cacatcgatt acgccgatag cgtggaaggc        900

cggttcacca tcagcagaga caacgccaag aacagcctgt acctgcagat gaactccctg        960

agagccgagg acaccgccgt gtactactgt gccaaagtgt cttacctgag caccgcctcc       1020

agcctggatt attggggaca gggcacactg gtcacagtgt cctctggtgg cggaggttct       1080

ggcggaggtg gtagtggtgg cggtggaagt ggtggcggcg gatctgatat ccagatgaca       1140

cagagcccta gcagcctgtc tgcctctgtg ggcgatagag tgaccatcac ctgtagagcc       1200

agccagggca tcagaaacta cctggcctgg tatcagcaga agcccggaaa ggcccctaag       1260

ctgctgatct atgccgcctc tacactgcag agcggcgtgc catctagatt ttctggcagc       1320

ggctctggca ccgacttcac cctgacaatt tctagcctgc agcctgagga cgtggccacc       1380

tactactgcc agagatacaa cagagcccct tacaccttcg gccagggcac caaggtggaa       1440

atcaag                                                                  1446


<210>    65
<211>    707
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    TNFai-02C09 HC heavy chain


<400>    65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
     50                  55                  60 

Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly
    210                 215                 220 

Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser
225                 230                 235                 240 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255 

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
            260                 265                 270 

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285 

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
    290                 295                 300 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
                325                 330                 335 

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350 

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
                405                 410                 415 

Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430 

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
    450                 455                 460 

Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser
465                 470                 475                 480 

Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Tyr Ala Trp
                485                 490                 495 

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
            500                 505                 510 

Arg Ile Lys Gly Glu Pro Asp Gly Gly Thr Thr Glu Tyr Ala Asp Ser
        515                 520                 525 

Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
    530                 535                 540 

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
545                 550                 555                 560 

Cys Val Ser Arg Arg Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val
                565                 570                 575 

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
            580                 585                 590 

Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro
        595                 600                 605 

Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg
    610                 615                 620 

Ala Ser Gln Ser Ile Gly Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro
625                 630                 635                 640 

Gly Asn Ala Pro Lys Leu Leu Ile Tyr Lys Ala Thr Ile Leu Glu Ser
                645                 650                 655 

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Ala
            660                 665                 670 

Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ser Ala Tyr Tyr Cys
        675                 680                 685 

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu
    690                 695                 700 

Glu Ile Lys
705        


<210>    66
<211>    2121
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TNFai-02C09 HC heavy chain


<400>    66
gaagtgcaac tggttgaatc tggcggagga ctggtgcagc ctggaagaag cctgagactg         60

tcttgtgccg ccagcggctt caccttcgat gattatgcca tgcactgggt ccgacaggcc        120

cctggaaaag gacttgaatg ggtgtccgcc atcacctgga acagcggcca catcgattac        180

gccgatagcg tggaaggccg gttcaccatc agcagagaca acgccaagaa cagcctgtac        240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc caaagtgtct        300

tacctgagca ccgcctccag cctggattat tggggacagg gcacactggt cacagtgtcc        360

tctgcttcca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc        420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg        480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc        540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag        600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag        660

tccaaatatg gtcccccatg cccaccatgc ccagcacctg agttcctggg gggaccatca        720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc        780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg        840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg        900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac        960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc       1020

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc       1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg       1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac       1200

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag       1260

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag       1320

agcctctccc tgtctctggg taaaggtggt ggcggatctg gcggcggagg aagcggaggc       1380

ggaggatccc aaatgcagct tgttcaatcc ggcggaggcc tggttaagcc tggcggatct       1440

ctgagagtgt cttgtgccgc cagcggcttc accttcaatt acgcctggat gagctgggtc       1500

cgacaggccc ctggaaaagg actggaatgg gtcggaagaa tcaagggcga gcctgatggc       1560

ggaaccacag agtacgccga tagcgtgaag ggcagattca ccatcagccg ggacaacagc       1620

aagaacaccc tgtacctgca gatgaactcc ctgagagccg aggacacagc cgtgtactac       1680

tgtgtgtcta gaagaggcct ggatgtgtgg ggccagggaa caacagtgac agtttcttct       1740

ggtggcggag gttctggcgg aggtggtagt ggtggcggtg gaagtggtgg cggcggatct       1800

gatatccaga tgacacagag ccctagcagc ctgtctgcct ctctgggcga tagagtgacc       1860

atcacatgtc gggccagcca gtctattgga cggtggctgg cctggtatca gcaaaagcct       1920

ggaaacgccc ctaagctgct gatctacaag gccaccatcc tggaaagcgg agtgccttct       1980

agattttctg gcagcggctc tggcaccgag tttgccctga caattagctc cctgcagcct       2040

gacgacttca gcgcctacta ctgccagcag tacaacagct acccctacac cttcggccag       2100

ggcacaaagc tggaaatcaa g                                                 2121


<210>    67
<211>    473
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    TNFai-02C09 LC light chain


<400>    67
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Gly Ser Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu
225                 230                 235                 240 

Val Lys Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe
                245                 250                 255 

Thr Phe Asn Tyr Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys
            260                 265                 270 

Gly Leu Glu Trp Val Gly Arg Ile Lys Gly Glu Pro Asp Gly Gly Thr
        275                 280                 285 

Thr Glu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
    290                 295                 300 

Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
305                 310                 315                 320 

Asp Thr Ala Val Tyr Tyr Cys Val Ser Arg Arg Gly Leu Asp Val Trp
                325                 330                 335 

Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
            340                 345                 350 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
        355                 360                 365 

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg
    370                 375                 380 

Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Arg Trp Leu Ala
385                 390                 395                 400 

Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile Tyr Lys
                405                 410                 415 

Ala Thr Ile Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
            420                 425                 430 

Ser Gly Thr Glu Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
        435                 440                 445 

Phe Ser Ala Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe
    450                 455                 460 

Gly Gln Gly Thr Lys Leu Glu Ile Lys
465                 470            


<210>    68
<211>    1419
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TNFai-02C09 LC light chain


<400>    68
gatatccaga tgacacagag ccctagcagc ctgtctgcct ctgtgggcga tagagtgacc         60

atcacctgta gagccagcca gggcatcaga aactacctgg cctggtatca gcagaagccc        120

ggaaaggccc ctaagctgct gatctatgcc gcctctacac tgcagagcgg cgtgccatct        180

agattttctg gcagcggctc tggcaccgac ttcaccctga caatttctag cctgcagcct        240

gaggacgtgg ccacctacta ctgccagaga tacaacagag ccccttacac cttcggccag        300

ggcaccaagg tggaaatcaa gcgtacggtg gcggcgccat ctgtcttcat cttcccgcca        360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat        420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag        480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg        540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc        600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggtggtgg cggatctggc        660

ggcggaggaa gcggaggcgg aggatcccaa atgcagcttg ttcaatccgg cggaggcctg        720

gttaagcctg gcggatctct gagagtgtct tgtgccgcca gcggcttcac cttcaattac        780

gcctggatga gctgggtccg acaggcccct ggaaaaggac tggaatgggt cggaagaatc        840

aagggcgagc ctgatggcgg aaccacagag tacgccgata gcgtgaaggg cagattcacc        900

atcagccggg acaacagcaa gaacaccctg tacctgcaga tgaactccct gagagccgag        960

gacacagccg tgtactactg tgtgtctaga agaggcctgg atgtgtgggg ccagggaaca       1020

acagtgacag tttcttctgg tggcggaggt tctggcggag gtggtagtgg tggcggtgga       1080

agtggtggcg gcggatctga tatccagatg acacagagcc ctagcagcct gtctgcctct       1140

ctgggcgata gagtgaccat cacatgtcgg gccagccagt ctattggacg gtggctggcc       1200

tggtatcagc aaaagcctgg aaacgcccct aagctgctga tctacaaggc caccatcctg       1260

gaaagcggag tgccttctag attttctggc agcggctctg gcaccgagtt tgccctgaca       1320

attagctccc tgcagcctga cgacttcagc gcctactact gccagcagta caacagctac       1380

ccctacacct tcggccaggg cacaaagctg gaaatcaag                              1419


<210>    69
<211>    711
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    TNFai-hu3F07 HC heavy chain


<400>    69
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
     50                  55                  60 

Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly
    210                 215                 220 

Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser
225                 230                 235                 240 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255 

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
            260                 265                 270 

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285 

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
    290                 295                 300 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
                325                 330                 335 

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350 

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
                405                 410                 415 

Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430 

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
    450                 455                 460 

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser
465                 470                 475                 480 

Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Pro Asp Tyr Trp
                485                 490                 495 

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
            500                 505                 510 

Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys
        515                 520                 525 

Ser Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met
    530                 535                 540 

Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
545                 550                 555                 560 

Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr
                565                 570                 575 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            580                 585                 590 

Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu
        595                 600                 605 

Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser
    610                 615                 620 

Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr
625                 630                 635                 640 

Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser
                645                 650                 655 

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
            660                 665                 670 

Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly
        675                 680                 685 

Val Tyr Tyr Cys Ser Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly
    690                 695                 700 

Gly Thr Lys Leu Glu Ile Lys
705                 710    


<210>    70
<211>    2133
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TNFai-hu3F07 HC heavy chain


<400>    70
gaagtgcaac tggttgaatc tggcggagga ctggtgcagc ctggaagaag cctgagactg         60

tcttgtgccg ccagcggctt caccttcgat gattatgcca tgcactgggt ccgacaggcc        120

cctggaaaag gacttgaatg ggtgtccgcc atcacctgga acagcggcca catcgattac        180

gccgatagcg tggaaggccg gttcaccatc agcagagaca acgccaagaa cagcctgtac        240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc caaagtgtct        300

tacctgagca ccgcctccag cctggattat tggggacagg gcacactggt cacagtgtcc        360

tctgcttcca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc        420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg        480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc        540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag        600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag        660

tccaaatatg gtcccccatg cccaccatgc ccagcacctg agttcctggg gggaccatca        720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc        780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg        840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg        900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac        960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc       1020

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc       1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg       1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac       1200

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag       1260

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag       1320

agcctctccc tgtctctggg taaaggtggt ggcggatctg gcggcggagg aagcggaggc       1380

ggaggatccc aagttcaact ggttcagtct ggcgccgaag tgaagaaacc aggcgccagc       1440

gtgaaggtgt cctgcaaggc ctctggcttc acattccccg actactggat gcactgggtt       1500

cgacaggctc caggacaggg actcgaatgg atgggcgaga tcgatcctcc taacggccgg       1560

accaactaca acgagaagtt caagagcaga gtgaccatga ccagagacac cagcatcagc       1620

accgcctaca tggaactgag cagactgaga agcgacgaca ccgccgtgta ctactgtgcc       1680

agaggcatct actacgtgga ctactggggc cagggcacca cagtgacagt tagctctggt       1740

ggcggaggtt ctggcggagg tggtagtggt ggcggtggaa gtggtggcgg cggatctgat       1800

atcgtgatga cacagagccc tctgagcctg cctgtgacac tgggagaacc tgccagcatc       1860

agctgtagaa gcagccagag cctggtgcac agcaacggca atacctacct gcactggtat       1920

ctgcagaagc ccggacagtc tccccagctg ctgatctaca aggtgtccaa cagattcagc       1980

ggcgtgcccg atagattttc tggcagcggc tctggcaccg acttcaccct gaagattagc       2040

agagtggaag ccgaggacgt gggcgtgtac tactgtagcc agtctaccca cgtgccacct       2100

acctttggcg gcggaacaaa gctggaaatc aag                                    2133


<210>    71
<211>    477
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    TNFai- hu3F07 LC light chain


<400>    71
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
225                 230                 235                 240 

Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe
                245                 250                 255 

Thr Phe Pro Asp Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln
            260                 265                 270 

Gly Leu Glu Trp Met Gly Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn
        275                 280                 285 

Tyr Asn Glu Lys Phe Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser
    290                 295                 300 

Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr
305                 310                 315                 320 

Ala Val Tyr Tyr Cys Ala Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly
                325                 330                 335 

Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
            340                 345                 350 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val
        355                 360                 365 

Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Glu Pro Ala
    370                 375                 380 

Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn
385                 390                 395                 400 

Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu
                405                 410                 415 

Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe
            420                 425                 430 

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val
        435                 440                 445 

Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser Thr His Val
    450                 455                 460 

Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
465                 470                 475        


<210>    72
<211>    1431
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TNFai- hu3F07 LC light chain


<400>    72
gatatccaga tgacacagag ccctagcagc ctgtctgcct ctgtgggcga tagagtgacc         60

atcacctgta gagccagcca gggcatcaga aactacctgg cctggtatca gcagaagccc        120

ggaaaggccc ctaagctgct gatctatgcc gcctctacac tgcagagcgg cgtgccatct        180

agattttctg gcagcggctc tggcaccgac ttcaccctga caatttctag cctgcagcct        240

gaggacgtgg ccacctacta ctgccagaga tacaacagag ccccttacac cttcggccag        300

ggcaccaagg tggaaatcaa gcgtacggtg gcggcgccat ctgtcttcat cttcccgcca        360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat        420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag        480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg        540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc        600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggtggtgg cggatctggc        660

ggcggaggaa gcggaggcgg aggatcccaa gttcaactgg ttcagtctgg cgccgaagtg        720

aagaaaccag gcgccagcgt gaaggtgtcc tgcaaggcct ctggcttcac attccccgac        780

tactggatgc actgggttcg acaggctcca ggacagggac tcgaatggat gggcgagatc        840

gatcctccta acggccggac caactacaac gagaagttca agagcagagt gaccatgacc        900

agagacacca gcatcagcac cgcctacatg gaactgagca gactgagaag cgacgacacc        960

gccgtgtact actgtgccag aggcatctac tacgtggact actggggcca gggcaccaca       1020

gtgacagtta gctctggtgg cggaggttct ggcggaggtg gtagtggtgg cggtggaagt       1080

ggtggcggcg gatctgatat cgtgatgaca cagagccctc tgagcctgcc tgtgacactg       1140

ggagaacctg ccagcatcag ctgtagaagc agccagagcc tggtgcacag caacggcaat       1200

acctacctgc actggtatct gcagaagccc ggacagtctc cccagctgct gatctacaag       1260

gtgtccaaca gattcagcgg cgtgcccgat agattttctg gcagcggctc tggcaccgac       1320

ttcaccctga agattagcag agtggaagcc gaggacgtgg gcgtgtacta ctgtagccag       1380

tctacccacg tgccacctac ctttggcggc ggaacaaagc tggaaatcaa g                1431


<210>    73
<211>    706
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    I3F07-TNFai HC heavy chain


<400>    73
Gln Ile Gln Leu Ala Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Pro Asp Tyr
             20                  25                  30 

Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Ser Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Asn Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110 

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125 

Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175 

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
            180                 185                 190 

Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr
        195                 200                 205 

Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro
    210                 215                 220 

Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
225                 230                 235                 240 

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                245                 250                 255 

Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
            260                 265                 270 

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
        275                 280                 285 

Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
    290                 295                 300 

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
305                 310                 315                 320 

Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
                325                 330                 335 

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
            340                 345                 350 

Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
        355                 360                 365 

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
    370                 375                 380 

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
385                 390                 395                 400 

Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
                405                 410                 415 

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
            420                 425                 430 

Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser
        435                 440                 445 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
    450                 455                 460 

Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys
465                 470                 475                 480 

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg
                485                 490                 495 

Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn
            500                 505                 510 

Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile
        515                 520                 525 

Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
    530                 535                 540 

Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu
545                 550                 555                 560 

Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                565                 570                 575 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            580                 585                 590 

Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
        595                 600                 605 

Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
    610                 615                 620 

Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
625                 630                 635                 640 

Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly
                645                 650                 655 

Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
            660                 665                 670 

Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln
        675                 680                 685 

Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu
    690                 695                 700 

Ile Lys
705    


<210>    74
<211>    2118
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    I3F07-TNFai HC heavy chain


<400>    74
cagattcagc tggctcagtc tggcgccgaa cttgtgaaac ctggcgcctc tgtgaagctg         60

agctgcaagg ccagcggctt cacctttcct gactactgga tgcactgggt caagcagagg        120

cctggacagg gactcgaatg gatcggcgag atcgatcctc ctaacggccg gaccaactac        180

aacgagaagt tcaagagcaa ggccacactg accgtggaca gcagcagcaa taccgcctac        240

atgcagctga gcagactgac ctctgaggac agcgccgtgt actactgtgc cagaggcatc        300

tactacgtgg actactgggg ccagggcaca accctgacag tttcttctgc ttccaccaag        360

ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc        420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc        480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc        540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaac        600

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttgagtccaa atatggtccc        660

ccatgcccac catgcccagc acctgagttc ctggggggac catcagtctt cctgttcccc        720

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg        780

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg        840

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc        900

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc        960

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga       1020

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc       1080

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat       1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc       1200

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca       1260

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct       1320

ctgggtaaag gtggtggcgg atctggcggc ggaggaagcg gaggcggagg atccgaagtg       1380

caactggttg aatctggcgg aggactggtg cagcctggaa gaagcctgag actgtcttgt       1440

gccgccagcg gcttcacctt cgatgattat gccatgcact gggtccgaca ggcccctgga       1500

aaaggacttg aatgggtgtc cgccatcacc tggaacagcg gccacatcga ttacgccgat       1560

agcgtggaag gccggttcac catcagcaga gacaacgcca agaacagcct gtacctgcag       1620

atgaactccc tgagagccga ggacaccgcc gtgtactact gtgccaaagt gtcttacctg       1680

agcaccgcct ccagcctgga ttattgggga cagggcacac tggtcacagt gtcctctggt       1740

ggcggaggtt ctggcggagg tggtagtggt ggcggtggaa gtggtggcgg cggatctgat       1800

atccagatga cacagagccc tagcagcctg tctgcctctg tgggcgatag agtgaccatc       1860

acctgtagag ccagccaggg catcagaaac tacctggcct ggtatcagca gaagcccgga       1920

aaggccccta agctgctgat ctatgccgcc tctacactgc agagcggcgt gccatctaga       1980

ttttctggca gcggctctgg caccgacttc accctgacaa tttctagcct gcagcctgag       2040

gacgtggcca cctactactg ccagagatac aacagagccc cttacacctt cggccagggc       2100

accaaggtgg aaatcaag                                                     2118


<210>    75
<211>    482
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    I3F07-TNFai LC light chain


<400>    75
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
  1               5                  10                  15 

Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
             20                  25                  30 

Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                 85                  90                  95 

Thr His Val Pro Pro Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys
            100                 105                 110 

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125 

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140 

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175 

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190 

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205 

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
225                 230                 235                 240 

Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys
                245                 250                 255 

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg
            260                 265                 270 

Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn
        275                 280                 285 

Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile
    290                 295                 300 

Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
305                 310                 315                 320 

Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu
                325                 330                 335 

Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            340                 345                 350 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
        355                 360                 365 

Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
    370                 375                 380 

Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
385                 390                 395                 400 

Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                405                 410                 415 

Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly
            420                 425                 430 

Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
        435                 440                 445 

Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln
    450                 455                 460 

Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu
465                 470                 475                 480 

Ile Lys
       


<210>    76
<211>    1446
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    I3F07-TNFai LC light chain


<400>    76
gatatcgtgc tgacacagag ccctctgagc ctgcctgttt ctctgggaga tcaggccagc         60

atcagctgca gatcctctca gagcctggtg cacagcaacg gcaataccta cctgcactgg        120

tatctgcaga agcccggcca gtctcctaag ctgctgatct acaaggtgtc caacaggttc        180

agcggcgtgc ccgatagatt ttctggctct ggcagcggca ccgacttcac cctgaagatt        240

tctagagtgg aagccgagga cctgggcgtg tacttctgtt ctcagtctac ccacgtgcca        300

cctacctttg gcggcggaag caagctggaa atcaagcgta cggtggcggc gccatctgtc        360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg        420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa        480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc        540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa        600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtggt        660

ggtggcggat ctggcggcgg aggaagcgga ggcggaggat ccgaagtgca actggttgaa        720

tctggcggag gactggtgca gcctggaaga agcctgagac tgtcttgtgc cgccagcggc        780

ttcaccttcg atgattatgc catgcactgg gtccgacagg cccctggaaa aggacttgaa        840

tgggtgtccg ccatcacctg gaacagcggc cacatcgatt acgccgatag cgtggaaggc        900

cggttcacca tcagcagaga caacgccaag aacagcctgt acctgcagat gaactccctg        960

agagccgagg acaccgccgt gtactactgt gccaaagtgt cttacctgag caccgcctcc       1020

agcctggatt attggggaca gggcacactg gtcacagtgt cctctggtgg cggaggttct       1080

ggcggaggtg gtagtggtgg cggtggaagt ggtggcggcg gatctgatat ccagatgaca       1140

cagagcccta gcagcctgtc tgcctctgtg ggcgatagag tgaccatcac ctgtagagcc       1200

agccagggca tcagaaacta cctggcctgg tatcagcaga agcccggaaa ggcccctaag       1260

ctgctgatct atgccgcctc tacactgcag agcggcgtgc catctagatt ttctggcagc       1320

ggctctggca ccgacttcac cctgacaatt tctagcctgc agcctgagga cgtggccacc       1380

tactactgcc agagatacaa cagagcccct tacaccttcg gccagggcac caaggtggaa       1440

atcaag                                                                  1446


<210>    77
<211>    711
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    TNFai- I3F07 HC heavy chain


<400>    77
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
     50                  55                  60 

Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly
    210                 215                 220 

Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser
225                 230                 235                 240 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255 

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
            260                 265                 270 

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285 

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
    290                 295                 300 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
                325                 330                 335 

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350 

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
                405                 410                 415 

Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430 

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
    450                 455                 460 

Ile Gln Leu Ala Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser
465                 470                 475                 480 

Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Pro Asp Tyr Trp
                485                 490                 495 

Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly
            500                 505                 510 

Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys
        515                 520                 525 

Ser Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Asn Thr Ala Tyr Met
    530                 535                 540 

Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala
545                 550                 555                 560 

Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
                565                 570                 575 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            580                 585                 590 

Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Leu
        595                 600                 605 

Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser
    610                 615                 620 

Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr
625                 630                 635                 640 

Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser
                645                 650                 655 

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
            660                 665                 670 

Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly
        675                 680                 685 

Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly
    690                 695                 700 

Gly Ser Lys Leu Glu Ile Lys
705                 710    


<210>    78
<211>    2133
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TNFai- I3F07 HC heavy chain


<400>    78
gaagtgcaac tggttgaatc tggcggagga ctggtgcagc ctggaagaag cctgagactg         60

tcttgtgccg ccagcggctt caccttcgat gattatgcca tgcactgggt ccgacaggcc        120

cctggaaaag gacttgaatg ggtgtccgcc atcacctgga acagcggcca catcgattac        180

gccgatagcg tggaaggccg gttcaccatc agcagagaca acgccaagaa cagcctgtac        240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc caaagtgtct        300

tacctgagca ccgcctccag cctggattat tggggacagg gcacactggt cacagtgtcc        360

tctgcttcca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc        420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg        480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc        540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag        600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag        660

tccaaatatg gtcccccatg cccaccatgc ccagcacctg agttcctggg gggaccatca        720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc        780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg        840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg        900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac        960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc       1020

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc       1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg       1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac       1200

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag       1260

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag       1320

agcctctccc tgtctctggg taaaggtggt ggcggatctg gcggcggagg aagcggaggc       1380

ggaggatccc agattcagct ggctcagtct ggcgccgaac ttgtgaaacc tggcgcctct       1440

gtgaagctga gctgcaaggc cagcggcttc acctttcctg actactggat gcactgggtc       1500

aagcagaggc ctggacaggg actcgaatgg atcggcgaga tcgatcctcc taacggccgg       1560

accaactaca acgagaagtt caagagcaag gccacactga ccgtggacag cagcagcaat       1620

accgcctaca tgcagctgag cagactgacc tctgaggaca gcgccgtgta ctactgtgcc       1680

agaggcatct actacgtgga ctactggggc cagggcacaa ccctgacagt ttcttctggt       1740

ggcggaggtt ctggcggagg tggtagtggt ggcggtggaa gtggtggcgg cggatctgat       1800

atcgtgctga cacagagccc tctgagcctg cctgtttctc tgggagatca ggccagcatc       1860

agctgcagat cctctcagag cctggtgcac agcaacggca atacctacct gcactggtat       1920

ctgcagaagc ccggccagtc tcctaagctg ctgatctaca aggtgtccaa caggttcagc       1980

ggcgtgcccg atagattttc tggctctggc agcggcaccg acttcaccct gaagatttct       2040

agagtggaag ccgaggacct gggcgtgtac ttctgttctc agtctaccca cgtgccacct       2100

acctttggcg gcggaagcaa gctggaaatc aag                                    2133


<210>    79
<211>    477
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    TNFai- I3F07 LC light chain


<400>    79
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Gly Ser Gln Ile Gln Leu Ala Gln Ser Gly Ala Glu Leu
225                 230                 235                 240 

Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe
                245                 250                 255 

Thr Phe Pro Asp Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln
            260                 265                 270 

Gly Leu Glu Trp Ile Gly Glu Ile Asp Pro Pro Asn Gly Arg Thr Asn
        275                 280                 285 

Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Ser Ser
    290                 295                 300 

Ser Asn Thr Ala Tyr Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser
305                 310                 315                 320 

Ala Val Tyr Tyr Cys Ala Arg Gly Ile Tyr Tyr Val Asp Tyr Trp Gly
                325                 330                 335 

Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
            340                 345                 350 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val
        355                 360                 365 

Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala
    370                 375                 380 

Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn
385                 390                 395                 400 

Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu
                405                 410                 415 

Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe
            420                 425                 430 

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val
        435                 440                 445 

Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val
    450                 455                 460 

Pro Pro Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys
465                 470                 475        


<210>    80
<211>    1431
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TNFai- I3F07 LC light chain


<400>    80
gatatccaga tgacacagag ccctagcagc ctgtctgcct ctgtgggcga tagagtgacc         60

atcacctgta gagccagcca gggcatcaga aactacctgg cctggtatca gcagaagccc        120

ggaaaggccc ctaagctgct gatctatgcc gcctctacac tgcagagcgg cgtgccatct        180

agattttctg gcagcggctc tggcaccgac ttcaccctga caatttctag cctgcagcct        240

gaggacgtgg ccacctacta ctgccagaga tacaacagag ccccttacac cttcggccag        300

ggcaccaagg tggaaatcaa gcgtacggtg gcggcgccat ctgtcttcat cttcccgcca        360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat        420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag        480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg        540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc        600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggtggtgg cggatctggc        660

ggcggaggaa gcggaggcgg aggatcccag attcagctgg ctcagtctgg cgccgaactt        720

gtgaaacctg gcgcctctgt gaagctgagc tgcaaggcca gcggcttcac ctttcctgac        780

tactggatgc actgggtcaa gcagaggcct ggacagggac tcgaatggat cggcgagatc        840

gatcctccta acggccggac caactacaac gagaagttca agagcaaggc cacactgacc        900

gtggacagca gcagcaatac cgcctacatg cagctgagca gactgacctc tgaggacagc        960

gccgtgtact actgtgccag aggcatctac tacgtggact actggggcca gggcacaacc       1020

ctgacagttt cttctggtgg cggaggttct ggcggaggtg gtagtggtgg cggtggaagt       1080

ggtggcggcg gatctgatat cgtgctgaca cagagccctc tgagcctgcc tgtttctctg       1140

ggagatcagg ccagcatcag ctgcagatcc tctcagagcc tggtgcacag caacggcaat       1200

acctacctgc actggtatct gcagaagccc ggccagtctc ctaagctgct gatctacaag       1260

gtgtccaaca ggttcagcgg cgtgcccgat agattttctg gctctggcag cggcaccgac       1320

ttcaccctga agatttctag agtggaagcc gaggacctgg gcgtgtactt ctgttctcag       1380

tctacccacg tgccacctac ctttggcggc ggaagcaagc tggaaatcaa g                1431


<210>    81
<211>    447
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ref. Ab heavy chain


<400>    81
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ile Ile Ser Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Thr Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Arg Leu Val Ala Pro Gly Thr Phe Asp Tyr Trp Gly Gln
            100                 105                 110 

Gly Ala Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125 

Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175 

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190 

Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205 

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220 

Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 

Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255 

Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270 

Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285 

Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300 

Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 

Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335 

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350 

Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365 

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380 

Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 

Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415 

Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430 

His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445 




<210>    82
<211>    214
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ref. Ab light chain


<400>    82
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys
    210                


<210>    83
<211>    448
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ref. TNFai heavy chain


<400>    83
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
     50                  55                  60 

Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly
    210                 215                 220 

Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser
225                 230                 235                 240 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255 

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
            260                 265                 270 

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285 

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
    290                 295                 300 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
                325                 330                 335 

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350 

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
                405                 410                 415 

Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430 

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445 




<210>    84
<211>    214
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ref. TNFai light chain


<400>    84
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys
    210                


<210>    85
<211>    710
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    O4L-TNFai HC heavy chain


<400>    85
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ile Ile Ser Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Thr Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Arg Leu Val Ala Pro Gly Thr Phe Asp Tyr Trp Gly Gln
            100                 105                 110 

Gly Ala Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125 

Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175 

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190 

Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205 

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220 

Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 

Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255 

Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270 

Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285 

Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300 

Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 

Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335 

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350 

Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365 

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380 

Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 

Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415 

Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430 

His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly
        435                 440                 445 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val
    450                 455                 460 

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu
465                 470                 475                 480 

Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met
                485                 490                 495 

His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala
            500                 505                 510 

Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly
        515                 520                 525 

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln
    530                 535                 540 

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
545                 550                 555                 560 

Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly
                565                 570                 575 

Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
            580                 585                 590 

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
        595                 600                 605 

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
    610                 615                 620 

Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln
625                 630                 635                 640 

Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr
                645                 650                 655 

Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
            660                 665                 670 

Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr
        675                 680                 685 

Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly
    690                 695                 700 

Thr Lys Val Glu Ile Lys
705                 710


<210>    86
<211>    2130
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    O4L-TNFai HC heavy chain


<400>    86
gaggtgcagc tgctggaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg         60

tcttgcgccg ccagcggctt caccttcaac agctacgcca tgagctgggt ccgacaggcc        120

cctggcaagg gcctggaatg ggtgtccatc atcagcggca gcggcggctt tacctactac        180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagccggac caccctgtac        240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caaggacaga        300

ctggtggccc caggcacctt cgactattgg ggacagggcg ccctcgtgac cgtgtcctct        360

gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag        420

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg        480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca        540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc        600

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc        660

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc        720

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg        780

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat        840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac        900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag        960

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa       1020

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag       1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag       1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc       1200

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg       1260

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc       1320

ctctccctgt ctctgggtaa aggtggtggc ggatctggcg gcggaggaag cggaggcgga       1380

ggatccgaag tgcaactggt tgaatctggc ggaggactgg tgcagcctgg aagaagcctg       1440

agactgtctt gtgccgccag cggcttcacc ttcgatgatt atgccatgca ctgggtccga       1500

caggcccctg gaaaaggact tgaatgggtg tccgccatca cctggaacag cggccacatc       1560

gattacgccg atagcgtgga aggccggttc accatcagca gagacaacgc caagaacagc       1620

ctgtacctgc agatgaactc cctgagagcc gaggacaccg ccgtgtacta ctgtgccaaa       1680

gtgtcttacc tgagcaccgc ctccagcctg gattattggg gacagggcac actggtcaca       1740

gtgtcctctg gtggcggagg ttctggcgga ggtggtagtg gtggcggtgg aagtggtggc       1800

ggcggatctg atatccagat gacacagagc cctagcagcc tgtctgcctc tgtgggcgat       1860

agagtgacca tcacctgtag agccagccag ggcatcagaa actacctggc ctggtatcag       1920

cagaagcccg gaaaggcccc taagctgctg atctatgccg cctctacact gcagagcggc       1980

gtgccatcta gattttctgg cagcggctct ggcaccgact tcaccctgac aatttctagc       2040

ctgcagcctg aggacgtggc cacctactac tgccagagat acaacagagc cccttacacc       2100

ttcggccagg gcaccaaggt ggaaatcaag                                        2130


<210>    87
<211>    477
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    O4L-TNFai LC light chain


<400>    87
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
225                 230                 235                 240 

Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                245                 250                 255 

Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys
            260                 265                 270 

Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp
        275                 280                 285 

Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
    290                 295                 300 

Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
305                 310                 315                 320 

Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser
                325                 330                 335 

Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
            340                 345                 350 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
        355                 360                 365 

Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
    370                 375                 380 

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg
385                 390                 395                 400 

Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                405                 410                 415 

Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe
            420                 425                 430 

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
        435                 440                 445 

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala
    450                 455                 460 

Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
465                 470                 475        


<210>    88
<211>    1431
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    O4L-TNFai LC light chain


<400>    88
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc         60

atcacctgtc gggccagcca gggcatcagc agctggctgg cctggtatca gcagaagccc        120

gagaaggccc ccaagagcct gatctacgcc gccagctctc tgcagagcgg cgtgcccagc        180

agattcagcg gcagcggctc cggcaccgac ttcaccctga ccatcagcag cctgcagccc        240

gaggacttcg ccacctacta ctgccagcag tacaacagct acccctacac cttcggccag        300

ggcaccaagc tggaaatcaa gcgtacggtg gcggcgccat ctgtcttcat cttcccgcca        360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat        420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag        480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg        540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc        600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggtggtgg cggatctggc        660

ggcggaggaa gcggaggcgg aggatccgaa gtgcaactgg ttgaatctgg cggaggactg        720

gtgcagcctg gaagaagcct gagactgtct tgtgccgcca gcggcttcac cttcgatgat        780

tatgccatgc actgggtccg acaggcccct ggaaaaggac ttgaatgggt gtccgccatc        840

acctggaaca gcggccacat cgattacgcc gatagcgtgg aaggccggtt caccatcagc        900

agagacaacg ccaagaacag cctgtacctg cagatgaact ccctgagagc cgaggacacc        960

gccgtgtact actgtgccaa agtgtcttac ctgagcaccg cctccagcct ggattattgg       1020

ggacagggca cactggtcac agtgtcctct ggtggcggag gttctggcgg aggtggtagt       1080

ggtggcggtg gaagtggtgg cggcggatct gatatccaga tgacacagag ccctagcagc       1140

ctgtctgcct ctgtgggcga tagagtgacc atcacctgta gagccagcca gggcatcaga       1200

aactacctgg cctggtatca gcagaagccc ggaaaggccc ctaagctgct gatctatgcc       1260

gcctctacac tgcagagcgg cgtgccatct agattttctg gcagcggctc tggcaccgac       1320

ttcaccctga caatttctag cctgcagcct gaggacgtgg ccacctacta ctgccagaga       1380

tacaacagag ccccttacac cttcggccag ggcaccaagg tggaaatcaa g                1431


<210>    89
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VH CDR 1


<400>    89
Asp Tyr Ala Met His
  1               5


<210>    90
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VH CDR 2


<400>    90
Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu
  1               5                  10                  15 

Gly
   


<210>    91
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VH CDR 3


<400>    91
Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr
  1               5                  10        


<210>    92
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VL CDR 1


<400>    92
Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala
  1               5                  10    


<210>    93
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VL CDR 2


<400>    93
Ala Ala Ser Thr Leu Gln Ser
  1               5        


<210>    94
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Humira VL CDR 3


<400>    94
Gln Arg Tyr Asn Arg Ala Pro Tyr Thr
  1               5                
