               SEQUENCE LISTING

<110> Ablynx NV
      Sanofi

<120> T CELL RECRUITING POLYPEPTIDES BASED ON TCR ALPHA/BETA REACTIVITY

<130> 242224

<150> EP20306608
<151> 2020-12-18

<160> 464

<170> BiSSAP 1.3.6

<210> 1
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 2
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 3
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 4
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 5
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 6
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 7
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Glu Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 8
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 9
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 10
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 11
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 12
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 12
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 13
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 13
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 14
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 14
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 15
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gln Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 16
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Phe 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 17
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Tyr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 18
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Val Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 19
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Phe Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 20
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 21
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 22
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala Val Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 23
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Ala Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 24
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Glu Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 25
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Val Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 26
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 26
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 27
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Ser Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 28
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala Met Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 29
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Glu Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 30
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp His Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 31
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Lys Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 32
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Arg Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 33
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 34
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asn Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 35
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 36
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 37
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 38
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 39
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 40
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Ser Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 41
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Gln Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 42
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Ser Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 43
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Leu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 44
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 45
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 46
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 47
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 48
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 49
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 50
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 50
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 51
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 52
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 53
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 54
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 54
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 55
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 56
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 56
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 57
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 58
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 59
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 60
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 60
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 61
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 62
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 63
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 64
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 64
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 65
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 66
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 66
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 67
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 68
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 68
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 69
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 69
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 70
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 70
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Ser Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 71
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 72
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 72
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 73
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 73
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 74
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 74
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 75
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 75
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 76
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 76
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 77
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 77
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 78
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 78
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 79
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Gln Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 80
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 81
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 81
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 82
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 82
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 83
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 83
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 84
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 84
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 85
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 85
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 86
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 86
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 87
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 87
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 88
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 88
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 89
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 89
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 90
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 90
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 91
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 91
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 92
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 93
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 93
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 94
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 94
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 95
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 95
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 96
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 96
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 97
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 97
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 98
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 98
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 99
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 99
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 100
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 100
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 101
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 101
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Ser Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Tyr Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 102
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 102
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 103
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 103
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 104
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 104
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 105
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 105
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 106
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 106
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 107
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 107
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 108
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 108
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 109
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 109
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 110
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 110
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 111
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 111
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 112
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 112
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 113
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 113
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Glu Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 114
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 114
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 115
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 115
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 116
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 116
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 117
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 117
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Asp Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 118
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 118
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 119
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 119
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 120
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 120
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 121
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 121
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 122
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 122
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 123
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 123
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 124
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 124
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 125
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 125
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 126
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 126
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 127
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 127
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 128
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 128
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Lys Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 129
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 129
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 130
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 130
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 131
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 131
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 132
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 132
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 133
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 133
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Glu Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 134
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 134
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Ala Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 135
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 135
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 136
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 136
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 137
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 137
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Lys Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 138
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 138
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 139
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 139
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 140
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 140
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Gln Leu Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 141
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 141
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 142
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 142
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 143
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 143
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 144
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 144
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 145
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 145
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 146
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 146
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Glu Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 147
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 147
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 148
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 148
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val His Gln Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Tyr Pro Tyr Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 149
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 149
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Ser Val His Gln Leu Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys Arg 
                85                  90                  95      
Ala Met Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 150
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 150
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 151
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 151
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 152
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 152
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 153
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 153
Gly Asp Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 154
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 154
Gly Tyr Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 155
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 155
Gly Asp Val His Lys Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 156
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 156
Gly Glu Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 157
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 157
Gly Ser Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 158
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 158
Gly Ala Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 159
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 159
Trp Asp Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 160
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 160
Tyr Asp Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 161
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 161
Gly Asp Val His Gln Ile Asn Phe Leu Gly 
1               5                   10  

<210> 162
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 162
Gly Asp Val His Lys Leu Asn Phe Leu Gly 
1               5                   10  

<210> 163
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 163
Gly Asp Val His Lys Ile Asn Phe Leu Thr 
1               5                   10  

<210> 164
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 164
Gln Asp Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  

<210> 165
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 165
Gly Asp Val His Lys Ile Phe Phe Leu Gly 
1               5                   10  

<210> 166
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 166
Gly Asp Val His Lys Ile Asn Tyr Leu Gly 
1               5                   10  

<210> 167
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 167
Gly Asp Val His Lys Ile Asn Val Leu Gly 
1               5                   10  

<210> 168
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 168
Gly Asp Val His Lys Ile Asn Phe Phe Gly 
1               5                   10  

<210> 169
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 169
Gly Asp Val His Lys Ile Asn Phe Leu Arg 
1               5                   10  

<210> 170
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 170
Gly Asp Val His Lys Ile Asn Phe Leu Ser 
1               5                   10  

<210> 171
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 171
Gly Tyr Val His Lys Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 172
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 172
Trp Asp Val His Lys Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 173
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 173
Tyr Asp Val His Lys Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 174
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 174
Trp Asp Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 175
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 175
Trp Asp Val His Lys Ile Asn Phe Tyr Thr 
1               5                   10  

<210> 176
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 176
Gly Ser Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 177
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 177
Gly Asp Val His Gln Leu Asn Phe Leu Gly 
1               5                   10  

<210> 178
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 178
Trp Asp Val His Lys Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 179
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 179
Tyr Asp Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 180
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 180
Trp Asp Val His Gln Ile Asn Phe Leu Gly 
1               5                   10  

<210> 181
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 181
Trp Asp Val His Gln Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 182
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 182
Tyr Asp Val His Gln Ile Asn Phe Leu Gly 
1               5                   10  

<210> 183
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 183
Trp Ser Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 184
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 184
Gly Ser Val His Lys Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 185
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 185
Gly Tyr Val His Lys Leu Asn Phe Leu Gly 
1               5                   10  

<210> 186
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 186
Gly Tyr Val His Lys Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 187
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 187
Gly Ser Val His Gln Leu Asn Phe Leu Gly 
1               5                   10  

<210> 188
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 188
Gly Ala Val His Lys Leu Asn Phe Leu Gly 
1               5                   10  

<210> 189
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 189
Gly Ser Val His Gln Ile Asn Phe Leu Gly 
1               5                   10  

<210> 190
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 190
Gly Ser Val His Gln Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 191
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 191
Gly Ala Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 192
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 192
Gly Ala Val His Gln Ile Asn Phe Leu Gly 
1               5                   10  

<210> 193
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 193
Gly Asp Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 194
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 194
Gly Ala Val His Gln Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 195
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 195
Gly Ala Val His Lys Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 196
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 196
Gly Ser Val His Lys Leu Asn Phe Leu Gly 
1               5                   10  

<210> 197
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 197
Gly Ala Val His Lys Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 198
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 198
Gly Ser Val His Lys Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 199
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 199
Gly Tyr Val His Gln Ile Asn Phe Leu Gly 
1               5                   10  

<210> 200
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 200
Trp Ser Val His Gln Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 201
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 201
Gly Tyr Val His Gln Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 202
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 202
Gly Tyr Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 203
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 203
Gly Glu Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 204
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 204
Trp Glu Val His Lys Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 205
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 205
Tyr Ala Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 206
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 206
Tyr Asp Val His Gln Leu Asn Phe Tyr Gly 
1               5                   10  

<210> 207
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 207
Trp Glu Val His Gln Ile Asn Phe Tyr Gly 
1               5                   10  

<210> 208
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 208
Tyr Ser Val His Gln Leu Asn Phe Leu Gly 
1               5                   10  

<210> 209
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 209
His Ile Ser Ile Gly Asp Gln Thr Asp 
1               5                   

<210> 210
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 210
Val Ile Ser Ile Gly Asp Gln Thr Asp 
1               5                   

<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 211
His Ile Ser Ile Ala Asp Gln Thr Asp 
1               5                   

<210> 212
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 212
His Ile Ser Ile Gly Asp Glu Thr Asp 
1               5                   

<210> 213
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 213
His Ile Ser Ile Gly Asp Val Thr Asp 
1               5                   

<210> 214
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 214
His Ile Ser Ile Gly Asp Gln Val Asp 
1               5                   

<210> 215
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 215
His Ile Ser Ile Gly Asp Gln Ser Asp 
1               5                   

<210> 216
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 216
Met Ile Ser Ile Gly Asp Gln Thr Asp 
1               5                   

<210> 217
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 217
His Ile Ser Ile Gly Glu Gln Thr Asp 
1               5                   

<210> 218
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 218
His Ile Ser Ile Gly Asp His Thr Asp 
1               5                   

<210> 219
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 219
His Ile Ser Ile Gly Asp Lys Thr Asp 
1               5                   

<210> 220
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 220
His Ile Ser Ile Gly Asp Arg Thr Asp 
1               5                   

<210> 221
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 221
His Ile Ser Ile Gly Asp Gln Ala Asp 
1               5                   

<210> 222
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 222
His Ile Ser Ile Gly Asp Gln Thr Asn 
1               5                   

<210> 223
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 223
Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr 
1               5                   

<210> 224
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 224
Leu Ser Arg Ile Tyr Pro Tyr Asp Tyr 
1               5                   

<210> 225
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 225
Phe Ser Arg Ile Trp Pro Tyr Asp Tyr 
1               5                   

<210> 226
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 226
Met Ser Arg Ile Tyr Pro Tyr Asp Tyr 
1               5                   

<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 227
Phe Ser Lys Ile Tyr Pro Tyr Asp Tyr 
1               5                   

<210> 228
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 228
Phe Ser Arg Ile Tyr Pro Tyr Asp Trp 
1               5                   

<210> 229
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 229
Phe Ser Ser Ile Tyr Pro Tyr Asp Tyr 
1               5                   

<210> 230
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 230
Phe Ser Arg Ile Tyr Pro Tyr Gln Tyr 
1               5                   

<210> 231
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 231
Phe Ser Arg Ile Tyr Pro Tyr Ser Tyr 
1               5                   

<210> 232
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 232
Phe Ser Arg Ile Tyr Pro Tyr Leu Tyr 
1               5                   

<210> 233
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 233
Phe Ser Arg Ile Tyr Pro Tyr Ala Tyr 
1               5                   

<210> 234
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 234
Phe Ser Arg Ile Tyr Pro Tyr Thr Tyr 
1               5                   

<210> 235
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 235
Leu Ser Arg Ile Trp Pro Tyr Asp Tyr 
1               5                   

<210> 236
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 236
Leu Ser Lys Ile Trp Pro Tyr Asp Tyr 
1               5                   

<210> 237
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 237
Met Ser Lys Ile Trp Pro Tyr Asp Tyr 
1               5                   

<210> 238
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 238
Phe Ser Lys Ile Trp Pro Tyr Asp Tyr 
1               5                   

<210> 239
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 239
Met Ser Lys Ile Tyr Pro Tyr Asp Tyr 
1               5                   

<210> 240
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 240
Met Ser Arg Ile Trp Pro Tyr Asp Tyr 
1               5                   

<210> 241
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 241
Phe Ser Lys Ile Trp Pro Tyr Asp Trp 
1               5                   

<210> 242
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 242
Met Ser Arg Ile Trp Pro Tyr Asp Trp 
1               5                   

<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 243
Phe Ser Arg Ile Trp Pro Tyr Asp Trp 
1               5                   

<210> 244
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 244
Met Ser Lys Ile Trp Pro Tyr Asp Trp 
1               5                   

<210> 245
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 245
Met Ser Lys Ile Tyr Pro Tyr Asp Trp 
1               5                   

<210> 246
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 246
Met Ser Arg Ile Tyr Pro Tyr Asp Trp 
1               5                   

<210> 247
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 247
Leu Ser Lys Ile Tyr Pro Tyr Asp Tyr 
1               5                   

<210> 248
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR1

<400> 248
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  

<210> 249
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR1

<400> 249
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  

<210> 250
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR1

<400> 250
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  

<210> 251
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR2

<400> 251
Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala 
1               5                   10                  

<210> 252
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 252
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          
Ala Val Tyr Phe Cys Arg Ala 
        35                  

<210> 253
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 253
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Phe Cys Arg Ala 
        35                  

<210> 254
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 254
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Phe Cys Arg Ala 
        35                  

<210> 255
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 255
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Tyr Cys Arg Ala 
        35                  

<210> 256
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 256
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Tyr Cys Arg Ala 
        35                  

<210> 257
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 257
Tyr Ala Asp Ser Ala Lys Asp Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Phe Cys Arg Ala 
        35                  

<210> 258
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 258
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Ala Tyr Tyr Cys Arg Ala 
        35                  

<210> 259
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR3

<400> 259
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Thr Tyr Tyr Cys Arg Ala 
        35                  

<210> 260
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> FR4

<400> 260
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 261
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 261
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 262
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 262
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 263
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 263
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 264
<211> 133
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 264
Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         
Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             
Val Thr Val Ser Ser 
    130             

<210> 265
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 265
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Tyr Trp Ser Asn Gly Lys Thr Gln Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ala Asp Lys Asp Glu Thr Gly Phe Arg Thr Leu Pro Ile Ala Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 266
<211> 127
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 266
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         
Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         

<210> 267
<211> 133
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent ISVD

<400> 267
Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         
Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             
Val Thr Val Ser Ser 
    130             

<210> 268
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 268
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            180                 185                 190         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        195                 200                 205             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 269
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 269
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
                165                 170                 175     
Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 270
<211> 428
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 270
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      
Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Pro Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Arg Thr Phe Ser Ser Tyr Val Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         
Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Tyr Trp Ser Asn Gly 
        195                 200                 205             
Lys Thr Gln Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly 
    210                 215                 220                 
Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Asn Pro 
225                 230                 235                 240 
Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala Asp Lys Asp Glu Thr Gly 
                245                 250                 255     
Phe Arg Thr Leu Pro Ile Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
305                 310                 315                 320 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                325                 330                 335     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            340                 345                 350         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        355                 360                 365             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    370                 375                 380                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
385                 390                 395                 400 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                405                 410                 415     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425             

<210> 271
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 271
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            180                 185                 190         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        195                 200                 205             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 272
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 272
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            180                 185                 190         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        195                 200                 205             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 273
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 273
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Trp 
                165                 170                 175     
Asp Val His Lys Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 274
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 274
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Tyr 
                165                 170                 175     
Asp Val His Lys Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 275
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 275
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            180                 185                 190         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        195                 200                 205             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 276
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 276
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
                165                 170                 175     
Tyr Val His Lys Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 277
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 277
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Gln Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            180                 185                 190         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        195                 200                 205             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 278
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 278
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Trp 
                165                 170                 175     
Asp Val His Gln Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 279
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 279
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            180                 185                 190         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        195                 200                 205             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 280
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 280
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Trp 
                165                 170                 175     
Asp Val His Lys Ile Asn Phe Tyr Thr Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 281
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 281
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Trp Asp Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            180                 185                 190         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        195                 200                 205             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 282
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 282
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Trp 
                165                 170                 175     
Asp Val His Lys Ile Asn Phe Tyr Thr Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Lys Ile Trp Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265             

<210> 283
<211> 428
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 283
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Gly Pro Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Arg Thr Phe Ser Ser Tyr Val Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         
Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Tyr Trp Ser Asn Gly 
        195                 200                 205             
Lys Thr Gln Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly 
    210                 215                 220                 
Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Asn Pro 
225                 230                 235                 240 
Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala Asp Lys Asp Glu Thr Gly 
                245                 250                 255     
Phe Arg Thr Leu Pro Ile Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
305                 310                 315                 320 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                325                 330                 335     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            340                 345                 350         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        355                 360                 365             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    370                 375                 380                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
385                 390                 395                 400 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                405                 410                 415     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425             

<210> 284
<211> 428
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 284
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
                165                 170                 175     
Tyr Val His Lys Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        195                 200                 205             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    210                 215                 220                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr 
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Pro Leu 
305                 310                 315                 320 
Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr Val Met 
                325                 330                 335     
Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
            340                 345                 350         
Ile Tyr Trp Ser Asn Gly Lys Thr Gln Tyr Thr Asp Ser Val Lys Gly 
        355                 360                 365             
Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
    370                 375                 380                 
Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala 
385                 390                 395                 400 
Asp Lys Asp Glu Thr Gly Phe Arg Thr Leu Pro Ile Ala Tyr Asp Tyr 
                405                 410                 415     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425             

<210> 285
<211> 442
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 285
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         
Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Asp Gly 
        195                 200                 205             
Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 
Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Thr Ser Thr Asn 
                245                 250                 255     
Pro Gly Ser Tyr Ile Tyr Ile Trp Ala Tyr Asp Tyr Trp Gly Gln Gly 
            260                 265                 270         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 
Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys 
                325                 330                 335     
Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg 
            340                 345                 350         
Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser 
        355                 360                 365             
Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Thr Ser 
                405                 410                 415     
Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp Ala Tyr Asp Tyr Trp Gly 
            420                 425                 430         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        435                 440         

<210> 286
<211> 442
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 286
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         
Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
                165                 170                 175     
Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys 
            180                 185                 190         
Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        195                 200                 205             
Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser 
    210                 215                 220                 
Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val 
225                 230                 235                 240 
Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr 
                245                 250                 255     
Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly 
            260                 265                 270         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 
Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys 
                325                 330                 335     
Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg 
            340                 345                 350         
Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser 
        355                 360                 365             
Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Thr Ser 
                405                 410                 415     
Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp Ala Tyr Asp Tyr Trp Gly 
            420                 425                 430         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        435                 440         

<210> 287
<211> 442
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 287
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         
Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
                165                 170                 175     
Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            180                 185                 190         
Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        195                 200                 205             
Phe Val Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp 
    210                 215                 220                 
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
225                 230                 235                 240 
Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                245                 250                 255     
Tyr Cys Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr 
            260                 265                 270         
Ile Trp Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                325                 330                 335     
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val 
            340                 345                 350         
His Lys Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
        355                 360                 365             
Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala 
    370                 375                 380                 
Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn 
385                 390                 395                 400 
Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu 
                405                 410                 415     
Tyr Tyr Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly 
            420                 425                 430         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        435                 440         

<210> 288
<211> 428
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 288
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Tyr Trp Ser Asn Gly Lys Thr Gln Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ala Asp Lys Asp Glu Thr Gly Phe Arg Thr Leu Pro Ile Ala Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            180                 185                 190         
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        195                 200                 205             
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    210                 215                 220                 
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
225                 230                 235                 240 
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                245                 250                 255     
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
                325                 330                 335     
Tyr Val His Lys Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly 
            340                 345                 350         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        355                 360                 365             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    370                 375                 380                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
385                 390                 395                 400 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr 
                405                 410                 415     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425             

<210> 289
<211> 428
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 289
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ser Lys Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Thr Pro Gly Asn Tyr Arg Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Thr Ala Thr Gly Thr Thr Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Phe Pro Pro Ile Ser Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Leu Val Gln Ala Gly Gly Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     
Arg Thr Phe Ser Ser Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Glu Arg Glu Phe Val Ala Ala Ile Tyr Trp Ser Asn Gly Lys Thr 
        195                 200                 205             
Gln Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn 
    210                 215                 220                 
Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Asn Pro Glu Asp 
225                 230                 235                 240 
Thr Ala Val Tyr Tyr Cys Val Ala Asp Lys Asp Glu Thr Gly Phe Arg 
                245                 250                 255     
Thr Leu Pro Ile Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
                325                 330                 335     
Tyr Val His Lys Ile Asn Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly 
            340                 345                 350         
Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
        355                 360                 365             
Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
    370                 375                 380                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
385                 390                 395                 400 
Ala Leu Tyr Tyr Cys Arg Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr 
                405                 410                 415     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425             

<210> 290
<211> 428
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISVD format

<400> 290
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Tyr Trp Ser Asn Gly Lys Thr Gln Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ala Asp Lys Asp Glu Thr Gly Phe Arg Thr Leu Pro Ile Ala Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
                165                 170                 175     
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            180                 185                 190         
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        195                 200                 205             
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    210                 215                 220                 
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                245                 250                 255     
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
305                 310                 315                 320 
Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                325                 330                 335     
Ser Gly Ile Thr Ser Lys Ile Asn Asp Met Gly Trp Tyr Arg Gln Thr 
            340                 345                 350         
Pro Gly Asn Tyr Arg Glu Trp Val Ala Ser Ile Thr Ala Thr Gly Thr 
        355                 360                 365             
Thr Asn Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    370                 375                 380                 
Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
385                 390                 395                 400 
Asp Thr Thr Val Tyr Tyr Cys Asn Thr Phe Pro Pro Ile Ser Asn Phe 
                405                 410                 415     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425             

<210> 291
<211> 96
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR alpha constant domain (derived from P01848)

<400> 291
Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      



<210> 292
<211> 131
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR beta constant domain (derived from P01850)

<400> 292
Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          
Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser Arg Leu 
65                  70                  75                  80  
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             
Ala Asp Cys 
    130     

<210> 293
<211> 96
<212> PRT
<213> Artificial Sequence


<220> 
<223> cynomolgus TCR-alpha constant domain (derived from AEA41865)

<400> 293
Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Gly Ser 
1               5                   10                  15      
Lys Ser Asn Asp Thr Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Val 
            20                  25                  30          
Met Asn Val Ser Gln Ser Lys Asp Ser Asp Val His Ile Thr Asp Lys 
        35                  40                  45              
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Gly Ala Val 
    50                  55                  60                  
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Thr Ser Ala Phe Lys Asp 
65                  70                  75                  80  
Ser Val Ile Pro Ala Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      



<210> 294
<211> 131
<212> PRT
<213> Artificial Sequence


<220> 
<223> cynomolgus TCR-beta constant domain (derived from AEA41868)

<400> 294
Glu Asp Leu Lys Lys Val Phe Pro Pro Lys Val Ala Val Phe Glu Pro 
1               5                   10                  15      
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          
Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  
Glu Gln Pro Ala Leu Glu Asp Ser Arg Tyr Ser Leu Ser Ser Arg Leu 
65                  70                  75                  80  
Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asp Asp Glu Trp Thr Glu Asp 
            100                 105                 110         
Arg Asp Lys Pro Ile Thr Gln Lys Ile Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             
Ala Asp Cys 
    130     

<210> 295
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is Gly, Trp, Gln, or Tyr

<220> 
<221> VARIANT
<222> 2
<223> Xaa at position 2 is Asp, Glu, Tyr, Ser, or Ala

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is Lys, or Gln

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is Ile, or Leu

<220> 
<221> VARIANT
<222> 7
<223> Xaa at position 7 is Asn, or Phe

<220> 
<221> VARIANT
<222> 8
<223> Xaa at position 8 is Phe, Val, or Tyr

<220> 
<221> VARIANT
<222> 9
<223> Xaa at position 9 is Leu, Tyr, or Phe

<220> 
<221> VARIANT
<222> 10
<223> Xaa at position 10 is Gly, Thr, or Arg

<400> 295
Xaa Xaa Val His Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  

<210> 296
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is His, or Val

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is Gly, or Ala

<220> 
<221> VARIANT
<222> 7
<223> Xaa at position 7 is Gln, Val, or Glu

<220> 
<221> VARIANT
<222> 8
<223> Xaa at position 8 is Thr, Ser, or Val

<400> 296
Xaa Ile Ser Ile Xaa Asp Xaa Xaa Asp 
1               5                   

<210> 297
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is Phe, Leu or Met

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is Arg, Lys, or Ser

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is Tyr, or Trp

<220> 
<221> VARIANT
<222> 8
<223> Xaa at position 8 is Asp, or Gln

<220> 
<221> VARIANT
<222> 9
<223> Xaa at position 9 is Tyr, or Trp

<400> 297
Xaa Ser Xaa Ile Xaa Pro Tyr Xaa Xaa 
1               5                   

<210> 298
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is Gly, Trp, or Tyr

<220> 
<221> VARIANT
<222> 2
<223> Xaa at position 2 is Asp, Glu, Tyr, Ser, or Ala

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is Lys, or Gln

<220> 
<221> VARIANT
<222> 6
<223> Xaa at position 6 is Ile, or Leu

<220> 
<221> VARIANT
<222> 9
<223> Xaa at position 9 is Leu, or Tyr

<220> 
<221> VARIANT
<222> 10
<223> Xaa at position 10 is Gly, or Thr

<400> 298
Xaa Xaa Val His Xaa Xaa Asn Phe Xaa Xaa 
1               5                   10  

<210> 299
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<220> 
<221> VARIANT
<222> 1
<223> Xaa at position 1 is Phe, Leu or Met

<220> 
<221> VARIANT
<222> 3
<223> Xaa at position 3 is Arg, or Lys

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is Tyr, or Trp

<220> 
<221> VARIANT
<222> 9
<223> Xaa at position 9 is Tyr, or Trp

<400> 299
Xaa Ser Xaa Ile Xaa Pro Tyr Asp Xaa 
1               5                   

<210> 300
<211> 171
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human CD3 delta (P04234)

<400> 300
Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      
Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          
Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              
Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  
Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  
Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      
Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         
Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             
Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 
Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 
Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     

<210> 301
<211> 180
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human CD3 gamma (derived from P09693)

<400> 301
Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      
Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          
Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              
Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  
Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  
Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      
Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         
Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             
Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 
Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 
Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     
Asn Gln Leu Arg 
            180 

<210> 302
<211> 205
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human CD3 epsilon (derived from P07766)

<400> 302
Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      
Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          
Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              
Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  
Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  
His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      
Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         
Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             
Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 
Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 
Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     
Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         
Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg 
        195                 200                 205 

<210> 303
<211> 164
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human CD3 zeta (P20963)

<400> 303
Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      
Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          
Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              
Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      
Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 
Leu Pro Pro Arg 
                

<210> 304
<211> 142
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR alpha constant domain (derived from P01848)

<400> 304
Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         

<210> 305
<211> 177
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR beta constant domain (derived from P01850)

<400> 305
Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          
Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser Arg Leu 
65                  70                  75                  80  
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             
Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 
Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     
Phe 
    

<210> 306
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR alpha variable domain derived from 2IAN

<400> 306
Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly Ala 
1               5                   10                  15      
Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu Gln 
            20                  25                  30          
Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr Ile 
        35                  40                  45              
Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val Ala 
    50                  55                  60                  
Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr Asp 
65                  70                  75                  80  
Ser Gly Val Tyr Phe Cys Ala Ala Leu Ile Gln Gly Ala Gln Lys Leu 
                85                  90                  95      
Val Phe Gly Gln Gly Thr Arg Leu Thr Ile Asn 
            100                 105         

<210> 307
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR alpha variable domain derived from 2XN9

<400> 307
Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu Ser Ile Gln Glu Gly Glu 
1               5                   10                  15      
Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser Val Phe Ser Ser Leu Gln 
            20                  25                  30          
Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro Val Leu Leu Val Thr Val 
        35                  40                  45              
Val Thr Gly Gly Glu Val Lys Lys Leu Lys Arg Leu Thr Phe Gln Phe 
    50                  55                  60                  
Gly Asp Ala Arg Lys Asp Ser Ser Leu His Ile Thr Ala Ala Gln Pro 
65                  70                  75                  80  
Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly Ala Gly Ser Gln Gly Asn 
                85                  90                  95      
Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys 
            100                 105             

<210> 308
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR alpha variable domain derived from 3TOE

<400> 308
Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
1               5                   10                  15      
Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
            20                  25                  30          
Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
        35                  40                  45              
Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
    50                  55                  60                  
Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
65                  70                  75                  80  
Leu Arg Asp Ala Ala Val Tyr Tyr Cys Thr Val Tyr Gly Gly Ala Thr 
                85                  90                  95      
Asn Lys Leu Ile Phe Gly Thr Gly Thr Leu Leu Ala Val Gln 
            100                 105                 110 

<210> 309
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR beta variable domain derived from 2IAN

<400> 309
Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Ile Leu Lys Ile Gly 
1               5                   10                  15      
Gln Ser Met Thr Leu Gln Cys Thr Gln Asp Met Asn His Asn Tyr Met 
            20                  25                  30          
Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Lys Leu Ile Tyr Tyr 
        35                  40                  45              
Ser Val Gly Ala Gly Ile Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  
Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Glu Leu 
65                  70                  75                  80  
Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Thr Tyr His 
                85                  90                  95      
Gly Thr Gly Tyr Phe Gly Glu Gly Ser Trp Leu Thr Val Val 
            100                 105                 110 

<210> 310
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR beta variable domain derived from 2XN9

<400> 310
Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly 
1               5                   10                  15      
Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met 
            20                  25                  30          
Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr 
        35                  40                  45              
Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr 
    50                  55                  60                  
Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser 
65                  70                  75                  80  
Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ser Arg 
                85                  90                  95      
Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         



<210> 311
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR beta variable domain derived from 3TOE

<400> 311
Val Val Ser Gln His Pro Ser Trp Val Ile Ala Lys Ser Gly Thr Ser 
1               5                   10                  15      
Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
            20                  25                  30          
Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
        35                  40                  45              
Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
    50                  55                  60                  
Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
65                  70                  75                  80  
Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Gly 
                85                  90                  95      
Gly Ser Tyr Asn Ser Pro Leu His Phe Gly Asn Gly Thr Arg Leu Thr 
            100                 105                 110         
Val Thr 
        

<210> 312
<211> 171
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cyno CD3 delta (NP_001274617)

<400> 312
Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      
Ser Gln Val Ser Pro Phe Lys Ile Pro Val Glu Glu Leu Glu Asp Arg 
            20                  25                  30          
Val Phe Val Lys Cys Asn Thr Ser Val Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              
Gly Thr Leu Leu Thr Asn Asn Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  
Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  
Asp Lys Glu Ser Ala Val Gln Val His Tyr Arg Met Cys Gln Asn Cys 
                85                  90                  95      
Val Glu Leu Asp Pro Ala Thr Leu Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         
Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             
Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 
Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 
Ser Arg Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     

<210> 313
<211> 181
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cyno CD3 gamma (BAJ16168)

<400> 313
Met Glu Gln Gly Lys Gly Leu Thr Gly Phe Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      
Leu Gln Gly Ser Leu Ala Gln Ser Phe Glu Glu Asn Arg Lys Leu Asn 
            20                  25                  30          
Val Tyr Asn Gln Glu Asp Gly Ser Val Leu Leu Thr Cys His Val Lys 
        35                  40                  45              
Asn Thr Asn Ile Thr Trp Phe Lys Glu Gly Lys Met Ile Asp Ile Leu 
    50                  55                  60                  
Thr Ala His Lys Asn Lys Trp Asn Leu Gly Ser Asn Thr Lys Asp Pro 
65                  70                  75                  80  
Arg Gly Val Tyr Gln Cys Lys Gly Ser Lys Asp Lys Ser Lys Thr Leu 
                85                  90                  95      
Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala 
            100                 105                 110         
Thr Ile Leu Gly Phe Val Phe Ala Glu Ile Ile Ser Ile Phe Phe Leu 
        115                 120                 125             
Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln Ser 
    130                 135                 140                 
Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr Gln 
145                 150                 155                 160 
Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly Asn 
                165                 170                 175     
Gln Leu Arg Arg Asn 
            180     

<210> 314
<211> 198
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cyno CD3 epsilon (Q95LI5)

<400> 314
Met Gln Ser Gly Thr Arg Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      
Ile Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr 
            20                  25                  30          
Gln Thr Pro Tyr Gln Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              
Cys Ser Gln His Leu Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys 
    50                  55                  60                  
Asn Lys Glu Asp Ser Gly Asp Arg Leu Phe Leu Pro Glu Phe Ser Glu 
65                  70                  75                  80  
Met Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro 
                85                  90                  95      
Glu Asp Ala Ser His His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn 
            100                 105                 110         
Cys Met Glu Met Asp Val Met Ala Val Ala Thr Ile Val Ile Val Asp 
        115                 120                 125             
Ile Cys Ile Thr Leu Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys 
    130                 135                 140                 
Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly 
145                 150                 155                 160 
Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn 
                165                 170                 175     
Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Gln Asp Leu Tyr Ser Gly 
            180                 185                 190         
Leu Asn Gln Arg Arg Ile 
        195             

<210> 315
<211> 164
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cyno CD3 zeta (XP_005539936)

<400> 315
Met Lys Trp Lys Glu Leu Val Thr Ala Ala Ile Leu Gln Ala Gln Phe 
1               5                   10                  15      
Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          
Tyr Leu Leu Asp Gly Ile Leu Phe Leu Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              
Leu Phe Leu Arg Ala Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      
Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         
Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr 
145                 150                 155                 160 
Leu Pro Pro Arg 
                

<210> 316
<211> 270
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rhesus TCR alpha (AEA41863)

<400> 316
Met Leu Leu Leu Leu Val Leu Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      
Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Ser Val 
            20                  25                  30          
Ser Glu Gly Val Pro Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Phe 
        35                  40                  45              
Ser Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  
Leu Leu Leu Lys Tyr Thr Ser Gly Thr Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  
Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      
Lys Ala Ser Ala His Val Ser Asp Ala Ala Glu Tyr Phe Cys Ala Leu 
            100                 105                 110         
Ala Arg Gly Ala Leu Val Phe Gly Lys Gly Thr Arg Leu Ser Val Ile 
        115                 120                 125             
Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Gly Ser 
    130                 135                 140                 
Lys Ser Asn Asp Thr Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Val 
145                 150                 155                 160 
Met Asn Val Ser Gln Ser Lys Asp Ser Asp Val His Ile Thr Asp Lys 
                165                 170                 175     
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Gly Ala Val 
            180                 185                 190         
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Thr Ser Ala Phe Lys Asp 
        195                 200                 205             
Ser Val Ile Pro Ala Asp Thr Phe Phe Pro Gly Thr Glu Ser Val Cys 
    210                 215                 220                 
Asp Ala Asn Leu Val Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 

<210> 317
<211> 310
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rhesus TCR beta (AEA41864)

<400> 317
Met Gly Phe Trp Thr Leu Cys Cys Val Ser Phe Cys Ile Leu Val Ala 
1               5                   10                  15      
Lys His Thr Asp Ala Gly Val Ile Gln Leu Pro Arg His Glu Val Thr 
            20                  25                  30          
Glu Met Gly Lys Glu Val Thr Leu Arg Cys Glu Pro Ile Ser Gly His 
        35                  40                  45              
Ser Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Phe 
    50                  55                  60                  
Leu Ile Tyr Phe Asn Asn Lys Ser Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  
Lys Asp Arg Phe Ser Ala Thr Met Pro Asp Ala Ser Phe Ser Thr Leu 
                85                  90                  95      
Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         
Ser Thr Pro Gly Gln Gly Arg Glu Lys Leu Phe Phe Gly Ser Gly Thr 
        115                 120                 125             
Gln Leu Ser Val Leu Glu Asp Leu Lys Lys Val Phe Pro Pro Lys Val 
    130                 135                 140                 
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Glu Asp Ser Arg Tyr Cys 
        195                 200                 205             
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
    210                 215                 220                 
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asp Asp 
225                 230                 235                 240 
Glu Trp Thr Glu Asp Arg Asp Lys Pro Ile Thr Gln Lys Ile Ser Ala 
                245                 250                 255     
Glu Val Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
            260                 265                 270         
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Met Leu Met Ala Met 
    290                 295                 300                 
Val Lys Arg Lys Asp Phe 
305                 310 

<210> 318
<211> 281
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR-zipper: alpha chain

<400> 318
Met Asn Met Arg Pro Val Thr Ser Ser Val Leu Val Leu Leu Leu Met 
1               5                   10                  15      
Leu Arg Arg Ser Asn Gly Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu 
            20                  25                  30          
Ser Ile Gln Glu Gly Glu Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser 
        35                  40                  45              
Val Phe Ser Ser Leu Gln Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro 
    50                  55                  60                  
Val Leu Leu Val Thr Val Val Thr Gly Gly Glu Val Lys Lys Leu Lys 
65                  70                  75                  80  
Arg Leu Thr Phe Gln Phe Gly Asp Ala Arg Lys Asp Ser Ser Leu His 
                85                  90                  95      
Ile Thr Ala Ala Gln Pro Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly 
            100                 105                 110         
Ala Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser 
        115                 120                 125             
Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     
Asp Lys Ser Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 
Ser Cys Ser Ser Ala Asp Leu Val Pro Arg Gly Ser Thr Thr Ala Pro 
225                 230                 235                 240 
Ser Ala Gln Leu Lys Lys Lys Leu Gln Ala Leu Lys Lys Lys Asn Ala 
                245                 250                 255     
Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Glu 
            260                 265                 270         
Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        275                 280     

<210> 319
<211> 329
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human TCR-zipper: beta chain

<400> 319
Met Ser Asn Thr Val Leu Ala Asp Ser Ala Trp Gly Ile Thr Leu Leu 
1               5                   10                  15      
Ser Trp Val Thr Val Phe Leu Leu Gly Thr Ser Ser Ala Asp Gly Gly 
            20                  25                  30          
Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn Val 
        35                  40                  45              
Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp Tyr 
    50                  55                  60                  
Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln Ile 
65                  70                  75                  80  
Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val Ser 
                85                  90                  95      
Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln Lys 
            100                 105                 110         
Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ser Arg Ser Ser Tyr 
        115                 120                 125             
Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu 
    130                 135                 140                 
Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
145                 150                 155                 160 
Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
                165                 170                 175     
Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         
Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
        195                 200                 205             
Ala Leu Asn Asp Ser Arg Tyr Ser Leu Ser Ser Arg Leu Arg Val Ser 
    210                 215                 220                 
Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
225                 230                 235                 240 
Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
                245                 250                 255     
Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
            260                 265                 270         
Ser Ser Ala Asp Leu Val Pro Arg Gly Ser Thr Thr Ala Pro Ser Ala 
        275                 280                 285             
Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Glu Asn Ala Gln Leu 
    290                 295                 300                 
Glu Trp Glu Leu Gln Ala Leu Glu Lys Glu Leu Ala Gln Thr Gly His 
305                 310                 315                 320 
His His His His His His His His His 
                325                 

<210> 320
<211> 277
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cyno TCR-zipper: alpha chain (derived from AEA41865)

<400> 320
Met Leu Leu Ile Thr Ser Val Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      
Val Asn Gly Gln Gln Ile Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          
Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              
Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  
Ile Met Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Ile 
65                  70                  75                  80  
Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      
Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Thr Thr Gly Val 
            100                 105                 110         
Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg Leu Thr Val Leu Pro Tyr 
        115                 120                 125             
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Gly Ser Lys Ser 
    130                 135                 140                 
Asn Asp Thr Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Val Met Asn 
145                 150                 155                 160 
Val Ser Gln Ser Lys Asp Ser Asp Val His Ile Thr Asp Lys Thr Val 
                165                 170                 175     
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Gly Ala Val Ala Trp 
            180                 185                 190         
Ser Asn Lys Ser Asp Phe Ala Cys Thr Ser Ala Phe Lys Asp Ser Val 
        195                 200                 205             
Ile Pro Ala Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Ser Ser 
    210                 215                 220                 
Ala Asp Leu Val Pro Arg Gly Ser Thr Thr Ala Pro Ser Ala Gln Leu 
225                 230                 235                 240 
Lys Lys Lys Leu Gln Ala Leu Lys Lys Lys Asn Ala Gln Leu Lys Trp 
                245                 250                 255     
Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Glu Gln Lys Leu Ile 
            260                 265                 270         
Ser Glu Glu Asp Leu 
        275         

<210> 321
<211> 321
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cyno TCR-zipper: beta chain (derived from AEA41866 and AEA41868)

<400> 321
Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          
Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              
Asp Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  
Ile His Tyr Ser Val Gly Glu Gly Ser Thr Glu Lys Gly Glu Val Pro 
65                  70                  75                  80  
Asp Gly Tyr Asn Val Thr Arg Ser Asn Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      
Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         
Ser Tyr Trp Thr Gly Arg Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             
Arg Leu Thr Val Ile Glu Asp Leu Lys Lys Val Phe Pro Pro Lys Val 
    130                 135                 140                 
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Glu Asp Ser Arg Tyr Ser 
        195                 200                 205             
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
    210                 215                 220                 
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asp Asp 
225                 230                 235                 240 
Glu Trp Thr Glu Asp Arg Asp Lys Pro Ile Thr Gln Lys Ile Ser Ala 
                245                 250                 255     
Glu Ala Trp Gly Arg Ala Asp Cys Ser Ser Ala Asp Leu Val Pro Arg 
            260                 265                 270         
Gly Ser Thr Thr Ala Pro Ser Ala Gln Leu Glu Lys Glu Leu Gln Ala 
        275                 280                 285             
Leu Glu Lys Glu Asn Ala Gln Leu Glu Trp Glu Leu Gln Ala Leu Glu 
    290                 295                 300                 
Lys Glu Leu Ala Gln Thr Gly His His His His His His His His His 
305                 310                 315                 320 
His 
    

<210> 322
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 322
Ala Ala Ala 
1           

<210> 323
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 323
Gly Gly Gly Gly Ser 
1               5   

<210> 324
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 324
Ser Gly Gly Ser Gly Gly Ser 
1               5           

<210> 325
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 325
Gly Gly Gly Gly Ser Gly Gly Ser 
1               5               

<210> 326
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 326
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   

<210> 327
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 327
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 328
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 328
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 329
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 329
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Ser 
        

<210> 330
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 330
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210> 331
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 331
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  

<210> 332
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 332
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  

<210> 333
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 333
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          
Gly Gly Ser 
        35  

<210> 334
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 334
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          
Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  

<210> 335
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 335
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210> 336
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 336
Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys 
1               5                   10                  15      
Thr His Thr Cys Pro Pro Cys Pro 
            20                  

<210> 337
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 337
Glu Pro Lys Thr Pro Lys Pro Gln Pro Ala Ala Ala 
1               5                   10          

<210> 338
<211> 62
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 338
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          

<210> 339
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 339
Val Thr Val Ser Ser 
1               5   

<210> 340
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 340
Val Lys Val Ser Ser 
1               5   

<210> 341
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 341
Val Gln Val Ser Ser 
1               5   

<210> 342
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 342
Val Thr Val Lys Ser 
1               5   

<210> 343
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 343
Val Thr Val Gln Ser 
1               5   

<210> 344
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 344
Val Lys Val Lys Ser 
1               5   

<210> 345
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 345
Val Lys Val Gln Ser 
1               5   

<210> 346
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 346
Val Gln Val Lys Ser 
1               5   

<210> 347
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 347
Val Gln Val Gln Ser 
1               5   

<210> 348
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 348
Val Thr Val Ser Ser Ala 
1               5       

<210> 349
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 349
Val Lys Val Ser Ser Ala 
1               5       

<210> 350
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 350
Val Gln Val Ser Ser Ala 
1               5       

<210> 351
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 351
Val Thr Val Lys Ser Ala 
1               5       

<210> 352
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 352
Val Thr Val Gln Ser Ala 
1               5       

<210> 353
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 353
Val Lys Val Lys Ser Ala 
1               5       

<210> 354
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 354
Val Lys Val Gln Ser Ala 
1               5       

<210> 355
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 355
Val Gln Val Lys Ser Ala 
1               5       

<210> 356
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminus

<400> 356
Val Gln Val Gln Ser Ala 
1               5       

<210> 357
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 357
Gly Phe Thr Phe Arg Ser Phe Gly Met Ser 
1               5                   10  

<210> 358
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1

<400> 358
Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
1               5                   10  

<210> 359
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2

<400> 359
Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
1               5                   10  

<210> 360
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3

<400> 360
Gly Gly Ser Leu Ser Arg 
1               5       

<210> 361
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 361
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 362
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 362
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 363
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 363
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 364
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 364
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 365
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 365
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 366
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 366
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 367
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 367
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 368
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 368
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 369
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 369
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 370
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 370
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 371
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 371
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 372
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 372
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 373
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 373
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 374
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 374
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 375
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 375
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 376
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 376
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 377
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 377
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 378
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Serum albumin binding ISVD

<400> 378
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 379
<211> 378
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human CD123 (NP_002174)

<400> 379
Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      
Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          
Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              
Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  
Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  
Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      
Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         
Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             
Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 
Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 
Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     
Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         
Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             
Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 
His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 
Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     
Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         
Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             
Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 
Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 
Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     
Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         
Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             
Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             

<210> 380
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 380
Lys Glu Arg Glu 
1               

<210> 381
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 381
Lys Gln Arg Glu 
1               

<210> 382
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 382
Gly Leu Glu Trp 
1               

<210> 383
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 383
Lys Glu Arg Glu Leu 
1               5   

<210> 384
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 384
Lys Glu Arg Glu Phe 
1               5   

<210> 385
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 385
Lys Gln Arg Glu Leu 
1               5   

<210> 386
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 386
Lys Gln Arg Glu Phe 
1               5   

<210> 387
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 387
Lys Glu Arg Glu Gly 
1               5   

<210> 388
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 388
Lys Gln Arg Glu Trp 
1               5   

<210> 389
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 389
Lys Gln Arg Glu Gly 
1               5   

<210> 390
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 390
Thr Glu Arg Glu 
1               

<210> 391
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 391
Thr Glu Arg Glu Leu 
1               5   

<210> 392
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 392
Thr Gln Arg Glu 
1               

<210> 393
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 393
Thr Gln Arg Glu Leu 
1               5   

<210> 394
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 394
Lys Glu Cys Glu 
1               

<210> 395
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 395
Lys Glu Cys Glu Leu 
1               5   

<210> 396
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 396
Lys Glu Cys Glu Arg 
1               5   

<210> 397
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 397
Lys Gln Cys Glu 
1               

<210> 398
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 398
Lys Gln Cys Glu Leu 
1               5   

<210> 399
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 399
Arg Glu Arg Glu 
1               

<210> 400
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 400
Arg Glu Arg Glu Gly 
1               5   

<210> 401
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 401
Arg Gln Arg Glu 
1               

<210> 402
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 402
Arg Gln Arg Glu Leu 
1               5   

<210> 403
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 403
Arg Gln Arg Glu Phe 
1               5   

<210> 404
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 404
Arg Gln Arg Glu Trp 
1               5   

<210> 405
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 405
Gln Glu Arg Glu 
1               

<210> 406
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 406
Gln Glu Arg Glu Gly 
1               5   

<210> 407
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 407
Gln Gln Arg Glu 
1               

<210> 408
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 408
Gln Gln Arg Glu Trp 
1               5   

<210> 409
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 409
Gln Gln Arg Glu Leu 
1               5   

<210> 410
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 410
Gln Gln Arg Glu Phe 
1               5   

<210> 411
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 411
Lys Gly Arg Glu 
1               

<210> 412
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 412
Lys Gly Arg Glu Gly 
1               5   

<210> 413
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 413
Lys Asp Arg Glu 
1               

<210> 414
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 414
Lys Asp Arg Glu Val 
1               5   

<210> 415
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 415
Asp Glu Cys Lys Leu 
1               5   

<210> 416
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 416
Asn Val Cys Glu Leu 
1               5   

<210> 417
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 417
Gly Val Glu Trp 
1               

<210> 418
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 418
Glu Pro Glu Trp 
1               

<210> 419
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 419
Gly Leu Glu Arg 
1               

<210> 420
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 420
Asp Gln Glu Trp 
1               

<210> 421
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 421
Asp Leu Glu Trp 
1               

<210> 422
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 422
Gly Ile Glu Trp 
1               

<210> 423
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 423
Glu Leu Glu Trp 
1               

<210> 424
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 424
Gly Pro Glu Trp 
1               

<210> 425
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 425
Glu Trp Leu Pro 
1               

<210> 426
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 426
Gly Pro Glu Arg 
1               

<210> 427
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 427
Gly Leu Glu Arg 
1               

<210> 428
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Motif from Table B-2

<400> 428
Glu Leu Glu Trp 
1               

<210> 429
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR

<220> 
<221> VARIANT
<222> 2
<223> Xaa at position 2 is Asp or Glu

<220> 
<221> VARIANT
<222> 5
<223> Xaa at position 5 is Lys or Gln

<400> 429
Gly Xaa Val His Xaa 
1               5   

<210> 430
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR

<400> 430
Gly Asp Val His Lys 
1               5   

<210> 431
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR

<400> 431
Gly Glu Val His Lys 
1               5   

<210> 432
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR

<400> 432
Gly Asp Val His Gln 
1               5   

<210> 433
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR

<400> 433
Gly Glu Val His Gln 
1               5   

<210> 434
<211> 426
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 434
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala 
                165                 170                 175     
Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg Arg Pro 
            180                 185                 190         
Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly Gly Val 
        195                 200                 205             
Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 
Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn Pro Glu 
225                 230                 235                 240 
Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly Pro Arg 
                245                 250                 255     
Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                325                 330                 335     
Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
            340                 345                 350         
Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
        355                 360                 365             
Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    370                 375                 380                 
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
385                 390                 395                 400 
Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
                405                 410                 415     
Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425     

<210> 435
<211> 394
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 435
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala 
    130                 135                 140                 
Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg Arg Pro 
145                 150                 155                 160 
Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly Gly Val 
                165                 170                 175     
Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         
Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn Pro Glu 
        195                 200                 205             
Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly Pro Arg 
    210                 215                 220                 
Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             
Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 
Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
305                 310                 315                 320 
Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
                325                 330                 335     
Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
        355                 360                 365             
Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
    370                 375                 380                 
Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
385                 390                 

<210> 436
<211> 396
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 436
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
                325                 330                 335     
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            340                 345                 350         
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
        355                 360                 365             
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
    370                 375                 380                 
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
385                 390                 395     

<210> 437
<211> 400
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 437
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        115                 120                 125             
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 
Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met 
145                 150                 155                 160 
Thr Trp Val Arg Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr 
                165                 170                 175     
Ile Thr Asn Gly Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg 
            180                 185                 190         
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met 
        195                 200                 205             
Thr Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala 
    210                 215                 220                 
Arg Arg Thr Gly Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly 
225                 230                 235                 240 
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             
Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu 
    290                 295                 300                 
Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 
Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     
Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             
Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 
Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
385                 390                 395                 400 



<210> 438
<211> 411
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 438
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val 
145                 150                 155                 160 
Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg Arg 
                165                 170                 175     
Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly Gly 
            180                 185                 190         
Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             
Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn Pro 
    210                 215                 220                 
Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly Pro 
225                 230                 235                 240 
Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu Val 
                245                 250                 255     
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 
Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 
Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                325                 330                 335     
Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
            340                 345                 350         
Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
    370                 375                 380                 
Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
385                 390                 395                 400 
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410     

<210> 439
<211> 550
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 439
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala 
    290                 295                 300                 
Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met Glu Trp 
305                 310                 315                 320 
Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg Ile Ala 
                325                 330                 335     
Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val Asp Leu 
        355                 360                 365             
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
    370                 375                 380                 
Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        435                 440                 445             
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 
    450                 455                 460                 
Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
465                 470                 475                 480 
Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
                485                 490                 495     
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            500                 505                 510         
Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr 
        515                 520                 525             
Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
    530                 535                 540                 
Val Thr Val Ser Ser Ala 
545                 550 

<210> 440
<211> 535
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 440
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val 
        275                 280                 285             
Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met Glu 
    290                 295                 300                 
Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg Ile 
305                 310                 315                 320 
Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser Val 
                325                 330                 335     
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val Asp 
            340                 345                 350         
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys 
        355                 360                 365             
Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            420                 425                 430         
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        435                 440                 445             
Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
    450                 455                 460                 
Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
465                 470                 475                 480 
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                485                 490                 495     
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu 
            500                 505                 510         
Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
        515                 520                 525             
Leu Val Thr Val Ser Ser Ala 
    530                 535 

<210> 441
<211> 524
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 441
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser 
        275                 280                 285             
Ser Ser Thr Met Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu 
    290                 295                 300                 
Leu Val Ala Arg Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu 
305                 310                 315                 320 
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     
Lys Lys Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         
Gly Val Tyr Phe Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu 
        355                 360                 365             
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                405                 410                 415     
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            420                 425                 430         
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
        435                 440                 445             
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
    450                 455                 460                 
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
465                 470                 475                 480 
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                485                 490                 495     
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
            500                 505                 510         
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        515                 520                 

<210> 442
<211> 550
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 442
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met 
145                 150                 155                 160 
Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg 
                165                 170                 175     
Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser 
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val 
        195                 200                 205             
Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe 
    210                 215                 220                 
Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        275                 280                 285             
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr 
    290                 295                 300                 
Phe Ser Ser Phe Ala Met Thr Trp Val Arg Arg Pro Pro Gly Lys Gly 
305                 310                 315                 320 
Leu Glu Trp Val Ala Thr Ile Thr Asn Gly Gly Val Thr Ser Tyr Arg 
                325                 330                 335     
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
            340                 345                 350         
Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn Pro Glu Asp Thr Ala Val 
        355                 360                 365             
Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly Pro Arg Ala Pro Thr Asp 
    370                 375                 380                 
Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        435                 440                 445             
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 
    450                 455                 460                 
Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
465                 470                 475                 480 
Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
                485                 490                 495     
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            500                 505                 510         
Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr 
        515                 520                 525             
Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
    530                 535                 540                 
Val Thr Val Ser Ser Ala 
545                 550 

<210> 443
<211> 535
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 443
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met 
145                 150                 155                 160 
Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg 
                165                 170                 175     
Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser 
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val 
        195                 200                 205             
Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe 
    210                 215                 220                 
Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     
Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            260                 265                 270         
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe 
        275                 280                 285             
Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg Arg Pro Pro Gly Lys 
    290                 295                 300                 
Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly Gly Val Thr Ser Tyr 
305                 310                 315                 320 
Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                325                 330                 335     
Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn Pro Glu Asp Thr Ala 
            340                 345                 350         
Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly Pro Arg Ala Pro Thr 
        355                 360                 365             
Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            420                 425                 430         
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        435                 440                 445             
Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
    450                 455                 460                 
Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
465                 470                 475                 480 
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                485                 490                 495     
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu 
            500                 505                 510         
Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
        515                 520                 525             
Leu Val Thr Val Ser Ser Ala 
    530                 535 

<210> 444
<211> 524
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 444
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met 
145                 150                 155                 160 
Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg 
                165                 170                 175     
Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser 
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val 
        195                 200                 205             
Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe 
    210                 215                 220                 
Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                245                 250                 255     
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            260                 265                 270         
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
        275                 280                 285             
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
    290                 295                 300                 
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
305                 310                 315                 320 
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
                325                 330                 335     
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
            340                 345                 350         
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
        355                 360                 365             
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                405                 410                 415     
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            420                 425                 430         
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
        435                 440                 445             
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
    450                 455                 460                 
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
465                 470                 475                 480 
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                485                 490                 495     
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
            500                 505                 510         
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        515                 520                 

<210> 445
<211> 396
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 445
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
                325                 330                 335     
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            340                 345                 350         
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
        355                 360                 365             
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
    370                 375                 380                 
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
385                 390                 395     

<210> 446
<211> 550
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 446
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala 
    290                 295                 300                 
Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met Glu Trp 
305                 310                 315                 320 
Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg Ile Ala 
                325                 330                 335     
Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val Asp Leu 
        355                 360                 365             
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
    370                 375                 380                 
Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        435                 440                 445             
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 
    450                 455                 460                 
Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
465                 470                 475                 480 
Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
                485                 490                 495     
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            500                 505                 510         
Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr 
        515                 520                 525             
Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
    530                 535                 540                 
Val Thr Val Ser Ser Ala 
545                 550 

<210> 447
<211> 520
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 447
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Ala Met Thr Trp Val Arg Arg Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Thr Asn Gly Gly Val Thr Ser Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Glu Met Thr Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala 
                85                  90                  95      
Asn Ala Arg Arg Thr Gly Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr 
            100                 105                 110         
Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
    130                 135                 140                 
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
145                 150                 155                 160 
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
                165                 170                 175     
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
            180                 185                 190         
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
        195                 200                 205             
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
    210                 215                 220                 
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                245                 250                 255     
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            260                 265                 270         
Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met 
        275                 280                 285             
Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg 
    290                 295                 300                 
Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser 
305                 310                 315                 320 
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val 
                325                 330                 335     
Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe 
            340                 345                 350         
Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        355                 360                 365             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                405                 410                 415     
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            420                 425                 430         
Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        435                 440                 445             
Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
    450                 455                 460                 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
465                 470                 475                 480 
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
                485                 490                 495     
Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
            500                 505                 510         
Thr Leu Val Thr Val Ser Ser Ala 
        515                 520 

<210> 448
<211> 524
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 448
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala 
    290                 295                 300                 
Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met Glu Trp 
305                 310                 315                 320 
Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg Ile Ala 
                325                 330                 335     
Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val Asp Leu 
        355                 360                 365             
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
    370                 375                 380                 
Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 
Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                405                 410                 415     
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            420                 425                 430         
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
        435                 440                 445             
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
    450                 455                 460                 
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
465                 470                 475                 480 
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                485                 490                 495     
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
            500                 505                 510         
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        515                 520                 

<210> 449
<211> 498
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 449
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
        275                 280                 285             
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
    290                 295                 300                 
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
305                 310                 315                 320 
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                325                 330                 335     
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
            340                 345                 350         
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
        355                 360                 365             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    370                 375                 380                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 
Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met 
                405                 410                 415     
Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu Leu Val Ala Arg 
            420                 425                 430         
Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu Tyr Ala Asp Ser 
        435                 440                 445             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val 
    450                 455                 460                 
Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe 
465                 470                 475                 480 
Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     
Ser Ala 
        

<210> 450
<211> 498
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 450
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser 
        275                 280                 285             
Ser Ser Thr Met Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu 
    290                 295                 300                 
Leu Val Ala Arg Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu 
305                 310                 315                 320 
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     
Lys Lys Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         
Gly Val Tyr Phe Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu 
        355                 360                 365             
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    370                 375                 380                 
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
385                 390                 395                 400 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                405                 410                 415     
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            420                 425                 430         
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        435                 440                 445             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    450                 455                 460                 
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
465                 470                 475                 480 
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     
Ser Ala 
        

<210> 451
<211> 524
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 451
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser 
        275                 280                 285             
Ser Ser Thr Met Glu Trp Tyr Arg Gln Pro Pro Gly Lys Lys Arg Glu 
    290                 295                 300                 
Leu Val Ala Arg Ile Ala Pro Gly Asp Gly Thr Asn Tyr Gly Ala Leu 
305                 310                 315                 320 
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     
Lys Lys Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         
Gly Val Tyr Phe Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu 
        355                 360                 365             
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                405                 410                 415     
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            420                 425                 430         
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
        435                 440                 445             
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
    450                 455                 460                 
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
465                 470                 475                 480 
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                485                 490                 495     
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
            500                 505                 510         
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        515                 520                 

<210> 452
<211> 396
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 452
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Ala Met Thr Trp Val Arg Arg Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Thr Asn Gly Gly Val Thr Ser Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Glu Met Thr Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala 
                85                  90                  95      
Asn Ala Arg Arg Thr Gly Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr 
            100                 105                 110         
Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
    130                 135                 140                 
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
145                 150                 155                 160 
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
                165                 170                 175     
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
            180                 185                 190         
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
        195                 200                 205             
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
    210                 215                 220                 
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
                325                 330                 335     
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            340                 345                 350         
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
        355                 360                 365             
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
    370                 375                 380                 
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
385                 390                 395     

<210> 453
<211> 370
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 453
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Val Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Gly 
                165                 170                 175     
Gly Val Thr Ser Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Thr Ser Leu Asn 
        195                 200                 205             
Pro Glu Asp Thr Ala Val Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
        275                 280                 285             
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
    290                 295                 300                 
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
305                 310                 315                 320 
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                325                 330                 335     
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
            340                 345                 350         
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
        355                 360                 365             
Ser Ala 
    370 

<210> 454
<211> 242
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 454
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        115                 120                 125             
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
145                 150                 155                 160 
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
                165                 170                 175     
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
    210                 215                 220                 
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 
Ser Ala 
        

<210> 455
<211> 381
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 455
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Ala 
                165                 170                 175     
Gly Val Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             
Pro Glu Asp Thr Ala Leu Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         
Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             
Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln 
    290                 295                 300                 
Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
305                 310                 315                 320 
Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     
Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         
Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
        355                 360                 365             
Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    370                 375                 380     

<210> 456
<211> 498
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 456
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Lys 
                165                 170                 175     
Gly Val Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             
Pro Glu Asp Thr Ala Leu Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser 
        275                 280                 285             
Ser Ser Thr Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Lys Arg Glu 
    290                 295                 300                 
Leu Val Ala Arg Ile Ala Pro Gly Glu Gly Thr Tyr Tyr Gly Ala Leu 
305                 310                 315                 320 
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                325                 330                 335     
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            340                 345                 350         
Ala Leu Tyr Tyr Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu 
        355                 360                 365             
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    370                 375                 380                 
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
385                 390                 395                 400 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                405                 410                 415     
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            420                 425                 430         
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        435                 440                 445             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    450                 455                 460                 
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
465                 470                 475                 480 
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     
Ser Ala 
        

<210> 457
<211> 509
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 457
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Ala Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met 
145                 150                 155                 160 
Glu Trp Tyr Arg Gln Ala Pro Gly Lys Lys Arg Glu Leu Val Ala Arg 
                165                 170                 175     
Ile Ala Pro Gly Glu Gly Thr Tyr Tyr Gly Ala Leu Tyr Ala Asp Ser 
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
        195                 200                 205             
Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr 
    210                 215                 220                 
Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     
Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            260                 265                 270         
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             
Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg Arg Pro Pro Gly Lys 
    290                 295                 300                 
Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Ala Gly Val Thr Ser Tyr 
305                 310                 315                 320 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                325                 330                 335     
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
            340                 345                 350         
Leu Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly Pro Arg Ala Pro Thr 
        355                 360                 365             
Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 
Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
385                 390                 395                 400 
Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                405                 410                 415     
Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln 
            420                 425                 430         
Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
        435                 440                 445             
Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    450                 455                 460                 
Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
465                 470                 475                 480 
Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
                485                 490                 495     
Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            500                 505                 

<210> 458
<211> 509
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 458
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Ala Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser Ser Ser Thr Met 
145                 150                 155                 160 
Glu Trp Tyr Arg Gln Ala Pro Gly Lys Lys Arg Glu Leu Val Ala Arg 
                165                 170                 175     
Ile Ala Pro Gly Glu Gly Thr Tyr Tyr Gly Ala Leu Tyr Ala Asp Ser 
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
        195                 200                 205             
Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr 
    210                 215                 220                 
Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     
Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            260                 265                 270         
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             
Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg Arg Pro Pro Gly Lys 
    290                 295                 300                 
Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Lys Gly Val Thr Ser Tyr 
305                 310                 315                 320 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                325                 330                 335     
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
            340                 345                 350         
Leu Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly Pro Arg Ala Pro Thr 
        355                 360                 365             
Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 
Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
385                 390                 395                 400 
Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                405                 410                 415     
Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln 
            420                 425                 430         
Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
        435                 440                 445             
Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    450                 455                 460                 
Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
465                 470                 475                 480 
Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
                485                 490                 495     
Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            500                 505                 

<210> 459
<211> 498
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multivalent polypeptide

<400> 459
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Thr Trp Val Arg 
145                 150                 155                 160 
Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Thr Asn Ala 
                165                 170                 175     
Gly Val Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         
Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             
Pro Glu Asp Thr Ala Leu Tyr Ile Cys Ala Asn Ala Arg Arg Thr Gly 
    210                 215                 220                 
Pro Arg Ala Pro Thr Asp Ile Gly Ser Tyr Arg Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ser Val Phe Ser 
        275                 280                 285             
Ser Ser Thr Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Lys Arg Glu 
    290                 295                 300                 
Leu Val Ala Arg Ile Ala Pro Gly Glu Gly Thr Tyr Tyr Gly Ala Leu 
305                 310                 315                 320 
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                325                 330                 335     
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            340                 345                 350         
Ala Leu Tyr Tyr Cys Ala Ser Gly Val Ala Trp Gly Gln Gly Thr Leu 
        355                 360                 365             
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    370                 375                 380                 
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
385                 390                 395                 400 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                405                 410                 415     
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            420                 425                 430         
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        435                 440                 445             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    450                 455                 460                 
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
465                 470                 475                 480 
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     
Ser Ala 
        

<210> 460
<211> 508
<212> PRT
<213> Artificial Sequence


<220> 
<223> TCRαβ-CD33-CD123 multispecific ISVD construct

<400> 460
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        115                 120                 125             
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 
Arg Leu Ser Cys Ala Ala Ser Gly Gly Val Phe Arg Leu Asn Ser Met 
145                 150                 155                 160 
Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ile 
                165                 170                 175     
Ile Thr Ser Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         
Phe Thr Ile Ser Arg Asp Gln Ala Lys Asn Thr Val Tyr Leu Gln Met 
        195                 200                 205             
Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Gln Ile Thr 
    210                 215                 220                 
Tyr Ser Thr Ser Ser Tyr Ser Phe Pro Ile Asn Thr Trp Gly Gln Gly 
225                 230                 235                 240 
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                245                 250                 255     
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
            260                 265                 270         
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ile Phe Ser Gly Asn 
        275                 280                 285             
Val Met Gly Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp 
    290                 295                 300                 
Val Ala Ala Ile Ala Glu Gly Gly Ser Ile Leu Tyr Arg Asp Ser Val 
305                 310                 315                 320 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
                325                 330                 335     
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
            340                 345                 350         
Asn Ser His Pro Pro Val Leu Pro Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
385                 390                 395                 400 
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                405                 410                 415     
Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
            420                 425                 430         
Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
        435                 440                 445             
Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    450                 455                 460                 
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
465                 470                 475                 480 
Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
                485                 490                 495     
Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            500                 505             

<210> 461
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> TCRαβ building block

<400> 461
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Val His Lys Ile Asn 
            20                  25                  30          
Phe Tyr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              
Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Arg 
                85                  90                  95      
Ala Leu Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 462
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent CD123 building block

<400> 462
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ile Phe Ser Gly Asn 
            20                  25                  30          
Val Met Gly Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp 
        35                  40                  45              
Val Ala Ala Ile Ala Glu Gly Gly Ser Ile Leu Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Asn Ser His Pro Pro Val Leu Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 463
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> monovalent CD33 building block

<400> 463
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Val Phe Arg Leu Asn 
            20                  25                  30          
Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Ile Ile Thr Ser Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Gln Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Gln 
                85                  90                  95      
Ile Thr Tyr Ser Thr Ser Ser Tyr Ser Phe Pro Ile Asn Thr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 464
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ALB23002

<400> 464
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

