                               SEQUENCE LISTING

<110> MOLECULAR PARTNERS AG
 
<120> NOVEL SLOW-RELEASE PRODRUGS

<130> 13081.0027-00304

<140>
<141>2021-12-16

<150> 63/182,394
<151> 2021-04-30

<150> EP 20216705
<151> 2020-12-22

<150> 63/126,356
<151> 2020-12-16

<160> 55    

<170> PatentIn version 3.5

<210> 1
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 1
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Phe Lys Gly Leu Thr Pro Leu His Leu Ala Ala Ala His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Val Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Ala Ser Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Trp Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ser His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 2
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 2
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Phe Lys Gly Leu Thr Pro Leu His Leu Ala Ala Ala His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Val Tyr Gly Trp Thr Pro Leu His Trp Ala Ala Ala Ser Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Trp Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ser His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 3
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 3
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Phe Lys Gly Leu Thr Pro Leu His Leu Ala Ala Ala His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Val Tyr Gly Trp Thr Pro Leu His Trp Ala Ala Ala Lys Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Trp Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ser His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 4
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 4
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Phe Lys Gly Leu Thr Pro Leu His Leu Ala Ala Glu His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Val Tyr Gly Trp Thr Pro Leu His Trp Ala Ala Ala Lys Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Trp Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ser His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 5
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 5
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


His Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Gln Ile Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Trp Ile Gly Tyr Thr Pro Leu His Leu Ala Ala Ser His Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Val Ser Gly Lys Thr Pro Leu His Val Ala Ala Ala His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 6
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 6
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Gln Tyr Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Ser Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Trp Val Gly Trp Thr Pro Leu His Leu Ala Ala Ser His Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Glu Ala Gly Arg Thr Pro Leu His Ile Ala Ala Lys Gln Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 7
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 7
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


His Tyr Gly Trp Thr Pro Leu His Leu Ala Ala Ala Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Trp Ile Gly Tyr Thr Pro Leu His Ile Ala Ala Ser His Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Ser Ser Gly Lys Thr Pro Leu His Ile Ala Ala Gln His Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 8
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 8
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


His Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Gln Arg Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Trp Leu Gly Trp Thr Pro Leu His Val Ala Ala Ser His Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Leu Ser Gly Arg Thr Pro Leu His Ile Ala Ala Arg Gln Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 9
<211> 159
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 9
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


His Tyr Gly Trp Thr Pro Leu His Leu Ala Ala Ser Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Trp Ile Gly Trp Thr Pro Leu His Leu Ala Ala Ser Phe Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Val Ser Gly Lys Thr Pro Leu His Ile Ala Ala Arg Gln Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Leu Gln Lys Ala Ala 
145                 150                 155                 


<210> 10
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Designed ankyrin repeat domain"

<400> 10
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


His Tyr Gly Trp Thr Pro Leu His Leu Ala Ala Ser Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Trp Ile Gly Trp Thr Pro Leu His Leu Ala Ala Ser Phe Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Val Ser Gly Lys Thr Pro Leu His Ile Ala Ala Arg Gln Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 


Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         


<210> 11
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD3-specific binding domain"

<400> 11
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          


Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              


Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         


His Gly Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 


<210> 12
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD3-specific binding domain"

<400> 12
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Ser Gln Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              


Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         


His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 


<210> 13
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD3-specific binding domain"

<400> 13
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          


Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              


Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         


His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 


<210> 14
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD3-specific binding domain"

<400> 14
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          


Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              


Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         


His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 


<210> 15
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD3-specific binding domain"

<400> 15
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          


Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              


Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Thr Asn Lys Arg Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Arg Asp Thr Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         


His Arg Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 


<210> 16
<211> 471
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Nucleic acid encoding a designed ankyrin repeat domain"

<400> 16
gacttaggaa agaaattgct gcaagccgca cgcgccggtc aacttgatga ggtgcgcgaa       60

ttattgaagg caggtgcaga cgtgaacgct aaagacttta agggacttac tcctttacac      120

ttagcggccg cacatggtca tttggaaatt gtggaggtcc tgttgaaggc tggcgccgac      180

gtgaacgcca aagatgttta cggttggacc ccattacaca ttgctgccgc ctcgggacat      240

ctggaaattg ttgaggttct gcttaaagct ggcgcagacg ttaatgccaa ggactggttg      300

gggattacgc ccttacacct ggccgcgtca catggacatt tagagattgt agaagtcctg      360

ttaaaggcgg gcgcggacgt taatgcccaa gacaaaagtg gcaaaacacc agcggatctg      420

gccgctcgtg ctggacacca ggacattgct gaagtgctgc agaaggcagc g               471


<210> 17
<211> 471
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Nucleic acid encoding a designed ankyrin repeat domain"

<400> 17
gacttaggaa agaaattgct gcaagccgca cgcgccggtc aacttgatga ggtgcgcgaa       60

ttattgaagg caggtgcaga cgtgaacgct aaagacttta agggacttac tcctttacac      120

ttagcggccg agcatggtca tttggaaatt gtggaggtcc tgttgaaggc tggcgccgac      180

gtgaacgcca aagatgttta cggttggacc ccattacact gggctgccgc caagggacat      240

ctggaaattg ttgaggttct gcttaaagct ggcgcagacg ttaatgccaa ggactggttg      300

gggattacgc ccttacacct ggccgcgtca catggacatt tagagattgt agaagtcctg      360

ttaaaggcgg gcgcggacgt taatgcccaa gacaaaagtg gcaaaacacc agcggatctg      420

gccgctcgtg ctggacacca ggacattgct gaagtgctgc agaaggcagc g               471


<210> 18
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Nucleic acid encoding a designed ankyrin repeat domain"

<400> 18
gacttgggga aaaaactgct tcaggctgca cgcgctggtc agttagatga ggtgcgtgag       60

ttgttaaaag ctggagcgga cgtaaatgct aaagatcatt acggatggac acccctgcat      120

cttgcagcgt cagaaggtca ccttgaaatc gtcgaggtcc ttttgaaagc aggggcagat      180

gtcaacgcca aggactggat cggttggacc cctcttcatt tagctgcttc gttcggtcat      240

ctggagattg tagaagtttt attaaaagcc ggtgcggatg tgaatgcaaa agatgtctca      300

gggaaaaccc cgttacacat cgccgctcgt caagggcatt tagagatcgt cgaggtactg      360

ttgaaagcgg gcgcagatgt caatgcacag gacaagtccg gcaaaactcc agcggattta      420

gctgcgcgcg caggacacca agacattgcg gaagtcttac aactgcagaa ggcagcg         477


<210> 19
<211> 471
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Nucleic acid encoding a designed ankyrin repeat domain"

<400> 19
gacttgggga aaaaactgct tcaggctgca cgcgctggtc agttagatga ggtgcgtgag       60

ttgttaaaag ctggagcgga cgtaaatgct aaagatcatt acggatggac acccctgcat      120

cttgcagcgt cagaaggtca ccttgaaatc gtcgaggtcc ttttgaaagc aggggcagat      180

gtcaacgcca aggactggat cggttggacc cctcttcatt tagctgcttc gttcggtcat      240

ctggagattg tagaagtttt attaaaagcc ggtgcggatg tgaatgcaaa agatgtctca      300

gggaaaaccc cgttacacat cgccgctcgt caagggcatt tagagatcgt cgaggtactg      360

ttgaaagcgg gcgcagatgt caatgcacag gacaagtccg gcaaaactcc agcggattta      420

gctgcgcgcg caggacacca agacattgcg gaagtcctgc agaaggcagc g               471


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="His-tag"

<400> 20
Met Arg Gly Ser His His His His His His Gly Ser 
1               5                   10          


<210> 21
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="N-terminal capping module"

<400> 21
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  


<210> 22
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="N-terminal capping module"

<400> 22
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  


<210> 23
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="N-terminal capping module"

<400> 23
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  


<210> 24
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="N-terminal capping module"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(12)
<223> Any amino acid

<400> 24
Asp Leu Gly Xaa Lys Leu Leu Gln Ala Ala Xaa Xaa Gly Gln Leu Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  


<210> 25
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<400> 25
Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 26
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Any amino acid

<400> 26
Lys Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 27
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Any amino acid

<400> 27
Lys Asp Xaa Xaa Gly Xaa Thr Pro Leu His Xaa Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 28
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="C-terminal capping module"

<400> 28
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
1               5                   10                  15      


His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            20                  25              


<210> 29
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="C-terminal capping module"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<400> 29
Xaa Asp Xaa Xaa Gly Xaa Thr Pro Ala Asp Xaa Ala Ala Arg Xaa Gly 
1               5                   10                  15      


His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            20                  25              


<210> 30
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 30
Lys Asp Phe Lys Gly Leu Thr Pro Leu His Leu Ala Ala Ala His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 31
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 31
Lys Asp Val Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Ala Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 32
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 32
Lys Asp Trp Leu Gly Ile Thr Pro Leu His Leu Ala Ala Ser His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 33
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 33
Lys Asp Val Tyr Gly Trp Thr Pro Leu His Trp Ala Ala Ala Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 34
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 34
Lys Asp Val Tyr Gly Trp Thr Pro Leu His Trp Ala Ala Ala Lys Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 35
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 35
Lys Asp Phe Lys Gly Leu Thr Pro Leu His Leu Ala Ala Glu His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 36
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 36
Lys Asp Val Tyr Gly Trp Thr Pro Leu His Trp Ala Ala Ala Lys Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 37
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 37
Lys Asp His Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Gln Ile Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 38
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 38
Lys Asp Trp Ile Gly Tyr Thr Pro Leu His Leu Ala Ala Ser His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 39
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 39
Lys Asp Val Ser Gly Lys Thr Pro Leu His Val Ala Ala Ala His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 40
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 40
Lys Asp Gln Tyr Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 41
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 41
Lys Asp Trp Val Gly Trp Thr Pro Leu His Leu Ala Ala Ser His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 42
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 42
Lys Asp Glu Ala Gly Arg Thr Pro Leu His Ile Ala Ala Lys Gln Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 43
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 43
Lys Asp His Tyr Gly Trp Thr Pro Leu His Leu Ala Ala Ala Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 44
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 44
Lys Asp Trp Ile Gly Tyr Thr Pro Leu His Ile Ala Ala Ser His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 45
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 45
Lys Asp Ser Ser Gly Lys Thr Pro Leu His Ile Ala Ala Gln His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 46
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 46
Lys Asp His Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Gln Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 47
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 47
Lys Asp Trp Leu Gly Trp Thr Pro Leu His Val Ala Ala Ser His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 48
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 48
Lys Asp Leu Ser Gly Arg Thr Pro Leu His Ile Ala Ala Arg Gln Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 49
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 49
Lys Asp His Tyr Gly Trp Thr Pro Leu His Leu Ala Ala Ser Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 50
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 50
Lys Asp Trp Ile Gly Trp Thr Pro Leu His Leu Ala Ala Ser Phe Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 51
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"

<400> 51
Lys Asp Val Ser Gly Lys Thr Pro Leu His Ile Ala Ala Arg Gln Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 52
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(15)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(19)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Any amino acid

<400> 52
Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Xaa Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Xaa Leu Val Xaa Val Leu Leu Xaa Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 53
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ankyrin repeat module"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Any amino acid

<400> 53
Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Glx Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210> 54
<211> 421
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TCE (without a half-life extending moiety)"

<400> 54
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          


Trp Leu Gly His Thr Pro Leu His Leu Ala Ala Tyr Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ile 
    50                  55                  60                  


Asp Asp Asn Asn Gly Phe Thr Pro Leu His Leu Ala Ala Ile Asp Gly 
65                  70                  75                  80  


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
            100                 105                 110         


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro 
        115                 120                 125             


Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
    130                 135                 140                 


Thr Pro Thr Gly Ser Asp Leu Gly Asp Lys Leu Leu Leu Ala Ala Thr 
145                 150                 155                 160 


Ser Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp 
                165                 170                 175     


Val Asn Ala Lys Asp Tyr Asp Gly Asp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         


Asp Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             


Asp Val Asn Ala Lys Asp Tyr Ser Gly Ser Thr Pro Leu His Ala Ala 
    210                 215                 220                 


Ala Ala Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 


Ala Asp Val Asn Ala Gln Asp Val Phe Gly Tyr Thr Pro Ala Asp Leu 
                245                 250                 255     


Ala Ala Tyr Val Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
            260                 265                 270         


Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
        275                 280                 285             


Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu 
    290                 295                 300                 


Glu Ala Ala Trp Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
305                 310                 315                 320 


Ala Gly Ala Asp Val Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu 
                325                 330                 335     


His Thr Ala Ala Gln Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu 
            340                 345                 350         


Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro 
        355                 360                 365             


Leu His Leu Ala Ala Ala Leu Gly His Leu Glu Ile Val Glu Val Leu 
    370                 375                 380                 


Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr 
385                 390                 395                 400 


Pro Ala Asp Leu Ala Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val 
                405                 410                 415     


Leu Gln Lys Ala Ala 
            420     


<210> 55
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TCE (with a half-life extending moiety)"

<400> 55
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              


Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Ala Asp Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         


His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             


Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 


Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 


Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     


Asn Ala Leu Asp Trp Leu Gly His Thr Pro Leu His Leu Ala Ala Tyr 
            180                 185                 190         


Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Ile Asp Asp Asn Asn Gly Phe Thr Pro Leu His Leu Ala 
    210                 215                 220                 


Ala Ile Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly 
225                 230                 235                 240 


Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
                245                 250                 255     


Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala 
            260                 265                 270         


Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
        275                 280                 285             


Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Asp Lys Leu Leu 
    290                 295                 300                 


Leu Ala Ala Thr Ser Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Ala 
305                 310                 315                 320 


Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Asp Gly Asp Thr Pro Leu 
                325                 330                 335     


His Leu Ala Ala Asp Glu Gly His Leu Glu Ile Val Glu Val Leu Leu 
            340                 345                 350         


Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Ser Gly Ser Thr Pro 
        355                 360                 365             


Leu His Ala Ala Ala Ala Tyr Gly His Leu Glu Ile Val Glu Val Leu 
    370                 375                 380                 


Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Val Phe Gly Tyr Thr 
385                 390                 395                 400 


Pro Ala Asp Leu Ala Ala Tyr Val Gly His Glu Asp Ile Ala Glu Val 
                405                 410                 415     


Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
            420                 425                 430         


Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
        435                 440                 445             


Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp Glu Val Arg 
    450                 455                 460                 


Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Ser Arg Gly 
465                 470                 475                 480 


Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu Glu Ile Phe 
                485                 490                 495     


Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Asp Lys 
            500                 505                 510         


Arg Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His Leu Glu Ile 
        515                 520                 525             


Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Arg Asp Ser 
    530                 535                 540                 


Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly His Gln Asp 
545                 550                 555                 560 


Ile Ala Glu Val Leu Gln Lys Ala Ala 
                565                 


