<110>    NUON BIO Co.,Ltd.

<120>    Compositions for treating or preventing muscle diseases, obesity
         or diabetes

<130>    PP210072

<160>    4

<170>    KoPatentIn 3.0

<210>    1
<211>    967
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    ADAMTS1


<400>    1
Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser
  1               5                  10                  15 

Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro
             20                  25                  30 

Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp
         35                  40                  45 

Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu
     50                  55                  60 

Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala
 65                  70                  75                  80 

Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu
                 85                  90                  95 

Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu
            100                 105                 110 

Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr
        115                 120                 125 

Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly
    130                 135                 140 

Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro
145                 150                 155                 160 

Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys
                165                 170                 175 

Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly
            180                 185                 190 

Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr
        195                 200                 205 

Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Gly Glu Asp
    210                 215                 220 

Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly
225                 230                 235                 240 

Gln Pro Thr Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser
                245                 250                 255 

His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met Ala Glu
            260                 265                 270 

Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe Ser Val
        275                 280                 285 

Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu
    290                 295                 300 

Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu
305                 310                 315                 320 

Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln
                325                 330                 335 

Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Thr
            340                 345                 350 

Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp
        355                 360                 365 

Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser Arg Ser
    370                 375                 380 

Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala
385                 390                 395                 400 

His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln
                405                 410                 415 

Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser
            420                 425                 430 

Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala
        435                 440                 445 

Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met
    450                 455                 460 

Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Thr
465                 470                 475                 480 

Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe Gly Glu Asp Ser
                485                 490                 495 

Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr Leu Trp Cys Thr
            500                 505                 510 

Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys His Phe Pro Trp
        515                 520                 525 

Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys
    530                 535                 540 

Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr Pro Phe His Gly
545                 550                 555                 560 

Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly
                565                 570                 575 

Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn Pro Val Pro Lys
            580                 585                 590 

Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys
        595                 600                 605 

Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr Phe Arg Glu Glu
    610                 615                 620 

Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly
625                 630                 635                 640 

Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp
                645                 650                 655 

Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val
            660                 665                 670 

Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser Pro Asp Ser Thr
        675                 680                 685 

Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile
    690                 695                 700 

Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn
705                 710                 715                 720 

Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr Ser Ala Lys Pro
                725                 730                 735 

Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala Thr Asn Ile Glu
            740                 745                 750 

Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu
        755                 760                 765 

Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn Gly Asp Tyr Thr
    770                 775                 780 

Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg
785                 790                 795                 800 

Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro
                805                 810                 815 

Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val Gly Asn Ala Leu
            820                 825                 830 

Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys Lys Lys Glu Ser
        835                 840                 845 

Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile Glu Glu Trp Gly
    850                 855                 860 

Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu
865                 870                 875                 880 

Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val
                885                 890                 895 

Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp
            900                 905                 910 

Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys Gly Lys Gly Tyr
        915                 920                 925 

Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser
    930                 935                 940 

His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe
945                 950                 955                 960 

Cys Thr Met Ala Glu Cys Ser
                965        


<210>    2
<211>    382
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    M3


<400>    2
Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser
  1               5                  10                  15 

Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro
             20                  25                  30 

Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp
         35                  40                  45 

Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu
     50                  55                  60 

Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala
 65                  70                  75                  80 

Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu
                 85                  90                  95 

Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu
            100                 105                 110 

Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr
        115                 120                 125 

Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly
    130                 135                 140 

Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro
145                 150                 155                 160 

Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys
                165                 170                 175 

Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly
            180                 185                 190 

Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr
        195                 200                 205 

Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Arg Phe Val
    210                 215                 220 

Ser Ser His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met
225                 230                 235                 240 

Ala Glu Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe
                245                 250                 255 

Ser Val Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val
            260                 265                 270 

Ser Leu Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly
        275                 280                 285 

Pro Glu Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn
    290                 295                 300 

Trp Gln Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr
305                 310                 315                 320 

Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr
                325                 330                 335 

Cys Asp Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser
            340                 345                 350 

Arg Ser Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr
        355                 360                 365 

Thr Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp
    370                 375                 380 




<210>    3
<211>    2904
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    ADAMTS1


<400>    3
atgcagcgag ctgtgcccga ggggttcgga aggcgcaagc tgggcagcga catggggaac         60

gcggagcggg ctccggggtc tcggagcttt gggccagtac ccacgctgct gctgctcgcc        120

gcggcgctac tggccgtgtc ggacgcactc gggcgcccct ccgaggagga cgaggagcta        180

gtggtgccgg agctggagcg cgccccggga cacgggacca cgcgcctccg cctgcacgcc        240

tttgaccagc agctggatct ggagctgcgg cccgacagca gctttttggc gcccggcttc        300

acgctccaga acgtggggcg caaatccggg tccgagacgc cgcttccgga aaccgacctg        360

gcgcactgct tctactccgg caccgtgaat ggcgatccca gctcggctgc cgccctcagc        420

ctctgcgagg gcgtgcgcgg cgccttctac ctgctggggg aggcgtattt catccagccg        480

ctgcccgccg ccagcgagcg cctcgccacc gccgccccag gggagaagcc gccggcacca        540

ctacagttcc acctcctgcg gcggaatcgg cagggcgacg tcggcggcac gtgcggggtc        600

gtggacgacg agccccggcc gactgggaaa gcggagaccg aagacgagga cgaagggact        660

gagggcgagg acgaaggggc tcagtggtcg ccgcaggacc cggcactgca aggcgtagga        720

cagcccacag gaactggaag cataagaaag aagcgatttg tgtccagtca ccgctatgtg        780

gaaaccatgc ttgtggcaga ccagtcgatg gcagaattcc acggcagtgg tctaaagcat        840

taccttctca cgttgttttc ggtggcagcc agattgtaca aacaccccag cattcgtaat        900

tcagttagcc tggtggtggt gaagatcttg gtcatccacg atgaacagaa ggggccggaa        960

gtgacctcca atgctgccct cactctgcgg aacttttgca actggcagaa gcagcacaac       1020

ccacccagtg accgggatgc agagcactat gacacagcaa ttcttttcac cagacaggac       1080

ttgtgtgggt cccagacatg tgatactctt gggatggctg atgttggaac tgtgtgtgat       1140

ccgagcagaa gctgctccgt catagaagat gatggtttac aagctgcctt caccacagcc       1200

catgaattag gccacgtgtt taacatgcca catgatgatg caaagcagtg tgccagcctt       1260

aatggtgtga accaggattc ccacatgatg gcgtcaatgc tttccaacct ggaccacagc       1320

cagccttggt ctccttgcag tgcctacatg attacatcat ttctggataa tggtcatggg       1380

gaatgtttga tggacaagcc tcagaatccc atacagctcc caggcgatct ccctggcacc       1440

tcgtacgatg ccaaccggca gtgccagttt acatttgggg aggactccaa acactgcccc       1500

gatgcagcca gcacatgtag caccttgtgg tgtaccggca cctctggtgg ggtgctggtg       1560

tgtcaaacca aacacttccc gtgggcggat ggcaccagct gtggagaagg gaaatggtgt       1620

atcaacggca agtgtgtgaa caaaaccgac agaaagcatt ttgatacgcc ttttcatgga       1680

agctggggaa tgtgggggcc ttggggagac tgttcgagaa cgtgcggtgg aggagtccag       1740

tacacgatga gggaatgtga caacccagtc ccaaagaatg gagggaagta ctgtgaaggc       1800

aaacgagtgc gctacagatc ctgtaacctt gaggactgtc cagacaataa tggaaaaacc       1860

tttagagagg aacaatgtga agcacacaac gagttttcaa aagcttcctt tgggagtggg       1920

cctgcggtgg aatggattcc caagtacgct ggcgtctcac caaaggacag gtgcaagctc       1980

atctgccaag ccaaaggcat tggctacttc ttcgttttgc agcccaaggt tgtagatggt       2040

actccatgta gcccagattc cacctctgtc tgtgtgcaag gacagtgtgt aaaagctggt       2100

tgtgatcgca tcatagactc caaaaagaag tttgataaat gtggtgtttg cgggggaaat       2160

ggatctactt gtaaaaaaat atcaggatca gttactagtg caaaacctgg atatcatgat       2220

atcatcacaa ttccaactgg agccaccaac atcgaagtga aacagcggaa ccagagggga       2280

tccaggaaca atggcagctt tcttgccatc aaagctgctg atggcacata tattcttaat       2340

ggtgactaca ctttgtccac cttagagcaa gacattatgt acaaaggtgt tgtcttgagg       2400

tacagcggct cctctgcggc attggaaaga attcgcagct ttagccctct caaagagccc       2460

ttgaccatcc aggttcttac tgtgggcaat gcccttcgac ctaaaattaa atacacctac       2520

ttcgtaaaga agaagaagga atctttcaat gctatcccca ctttttcagc atgggtcatt       2580

gaagagtggg gcgaatgttc taagtcatgt gaattgggtt ggcagagaag actggtagaa       2640

tgccgagaca ttaatggaca gcctgcttcc gagtgtgcaa aggaagtgaa gccagccagc       2700

accagacctt gtgcagacca tccctgcccc cagtggcagc tgggggagtg gtcatcatgt       2760

tctaagacct gtgggaaggg ttacaaaaaa agaagcttga agtgtctgtc ccatgatgga       2820

ggggtgttat ctcatgagag ctgtgatcct ttaaagaaac ctaaacattt catagacttt       2880

tgcacaatgg cagaatgcag ttaa                                              2904


<210>    4
<211>    1146
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    M3


<400>    4
atgcagcgag ctgtgcccga ggggttcgga aggcgcaagc tgggcagcga catggggaac         60

gcggagcggg ctccggggtc tcggagcttt gggccagtac ccacgctgct gctgctcgcc        120

gcggcgctac tggccgtgtc ggacgcactc gggcgcccct ccgaggagga cgaggagcta        180

gtggtgccgg agctggagcg cgccccggga cacgggacca cgcgcctccg cctgcacgcc        240

tttgaccagc agctggatct ggagctgcgg cccgacagca gctttttggc gcccggcttc        300

acgctccaga acgtggggcg caaatccggg tccgagacgc cgcttccgga aaccgacctg        360

gcgcactgct tctactccgg caccgtgaat ggcgatccca gctcggctgc cgccctcagc        420

ctctgcgagg gcgtgcgcgg cgccttctac ctgctggggg aggcgtattt catccagccg        480

ctgcccgccg ccagcgagcg cctcgccacc gccgccccag gggagaagcc gccggcacca        540

ctacagttcc acctcctgcg gcggaatcgg cagggcgacg tcggcggcac gtgcggggtc        600

gtggacgacg agccccggcc gactgggaaa gcggagaccg aagacgagga cgaagggact        660

gagcgatttg tgtccagtca ccgctatgtg gaaaccatgc ttgtggcaga ccagtcgatg        720

gcagaattcc acggcagtgg tctaaagcat taccttctca cgttgttttc ggtggcagcc        780

agattgtaca aacaccccag cattcgtaat tcagttagcc tggtggtggt gaagatcttg        840

gtcatccacg atgaacagaa ggggccggaa gtgacctcca atgctgccct cactctgcgg        900

aacttttgca actggcagaa gcagcacaac ccacccagtg accgggatgc agagcactat        960

gacacagcaa ttcttttcac cagacaggac ttgtgtgggt cccagacatg tgatactctt       1020

gggatggctg atgttggaac tgtgtgtgat ccgagcagaa gctgctccgt catagaagat       1080

gatggtttac aagctgcctt caccacagcc catgaattag gccacgtgtt taacatgcca       1140

catgat                                                                  1146
