                         SEQUENCE LISTING

<110>  Merus N.V.
 
<120>  Treatment of cancers with an antibody that binds LGR5 and EGFR

<130>  P129068PC00

<140>  PCT/NL2021/050763
<141>  2021-12-15

<150>  NL 2027118
<151>  2020-12-15

<160>  142   

<170>  PatentIn version 3.5

<210>  1
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


<210>  2
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  3
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 3370

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg His Trp His Trp Trp Leu Asp Ala Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  4
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 3755

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asp Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Arg Phe Leu Glu Trp Leu His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  5
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 4280

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Tyr Gly Lys Thr Phe Phe Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Ala Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Gly Tyr Tyr Glu Thr Thr Thr Tyr Tyr Tyr Asn Leu Phe 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 4289

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Thr Thr Asn Thr Gly Asp Pro Thr Tyr Ala Pro Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Tyr His Trp Ile Arg Gly Phe Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5790

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Ser 
            20                  25                  30          


Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Thr Tyr Ser Ser Ser Trp Asp Gly Val Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  8
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5803

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Ser Ile Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Tyr Tyr Thr Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Ile Val Val Val Pro Ala Ala Arg Asp Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5805

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ala Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser His 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Lys Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Val Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asn Ser Gly Ser Pro Arg Tyr Phe Glu Phe Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5808

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Glu Tyr Tyr Tyr Gly Ser Gly Ser Pro Ser Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5809

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Asp Ser Phe Ile Ser His 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Val Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Trp Glu Leu Leu Gly Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5814

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5816

<400>  13

Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5817

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Arg Asn Tyr Ala Gln Ile Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Leu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asp Glu Gly Asp Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 5818

<400>  15

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 3370

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 3370

<400>  17

Ser Tyr Gly Ile Ser 
1               5   


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 3370

<400>  18

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 3370

<400>  19

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 3370

<400>  20

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 3370

<400>  21

Asp Arg His Trp His Trp Trp Leu Asp Ala Phe Asp Tyr 
1               5                   10              


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 3370

<400>  22

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 3755

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asp Phe Thr 
            20                  25                  30  


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 3755

<400>  24

Asn Tyr Ala Met Asn 
1               5   


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 3755

<400>  25

Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 3755

<400>  26

Trp Ile Asn Ala Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 3755

<400>  27

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 3755

<400>  28

Glu Arg Phe Leu Glu Trp Leu His Phe Asp Tyr 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 3755

<400>  29

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 4280

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30  


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 4280

<400>  31

Glu Leu Ser Met His 
1               5   


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 4280

<400>  32

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 4280

<400>  33

Gly Phe Asp Pro Glu Tyr Gly Lys Thr Phe Phe Ala Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 4280

<400>  34

Arg Val Thr Met Thr Glu Asp Thr Ser Ala Asp Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 4280

<400>  35

Glu Gly Tyr Tyr Glu Thr Thr Thr Tyr Tyr Tyr Asn Leu Phe Asp Ser 
1               5                   10                  15      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 4280

<400>  36

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 4289

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 4289

<400>  38

Asp Tyr Ala Met Thr 
1               5   


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 4289

<400>  39

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 4289

<400>  40

Trp Ile Thr Thr Asn Thr Gly Asp Pro Thr Tyr Ala Pro Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 4289

<400>  41

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 4289

<400>  42

Val Tyr His Trp Ile Arg Gly Phe Glu Phe 
1               5                   10  


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 4289

<400>  43

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  44
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5790

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser 
            20                  25                  30  


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5790

<400>  45

Ser Ser Ser Ser Tyr Trp Gly 
1               5           


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5790

<400>  46

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5790

<400>  47

Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5790

<400>  48

Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5790

<400>  49

Gln Thr Tyr Ser Ser Ser Trp Asp Gly Val Leu Tyr Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5790

<400>  50

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  51
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5803

<400>  51

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Ser Ile Ser 
            20                  25                  30  


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5803

<400>  52

Thr Tyr Tyr Trp Ser 
1               5   


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5803

<400>  53

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5803

<400>  54

Tyr Val Tyr Tyr Thr Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  55
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5803

<400>  55

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Asn 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  56
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5803

<400>  56

Gly Gly Ile Val Val Val Pro Ala Ala Arg Asp Tyr Tyr Tyr Tyr Met 
1               5                   10                  15      


Asp Val 
        


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5803

<400>  57

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  58
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5805

<400>  58

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ala Cys Lys Gly Ser Gly Phe Ser Phe Thr 
            20                  25                  30  


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5805

<400>  59

Ser His Trp Ile Gly 
1               5   


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5805

<400>  60

Trp Val Arg Gln Lys Pro Gly Arg Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5805

<400>  61

Val Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5805

<400>  62

Gln Val Thr Val Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5805

<400>  63

Pro Asn Ser Gly Ser Pro Arg Tyr Phe Glu Phe 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5805

<400>  64

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  65
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5808

<400>  65

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser 
            20                  25                  30  


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5808

<400>  66

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5808

<400>  67

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5808

<400>  68

Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  69
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5808

<400>  69

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5808

<400>  70

Gln Glu Tyr Tyr Tyr Gly Ser Gly Ser Pro Ser Tyr Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5808

<400>  71

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  72
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5809

<400>  72

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Asp Ser Phe Ile 
            20                  25                  30  


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5809

<400>  73

Ser His Trp Ile Ala 
1               5   


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5809

<400>  74

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5809

<400>  75

Ile Val Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5809

<400>  76

Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5809

<400>  77

His Glu Trp Glu Leu Leu Gly Pro Phe Asp Tyr 
1               5                   10      


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5809

<400>  78

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  79
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5814

<400>  79

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr 
            20                  25                  30  


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5814

<400>  80

Asn Asp Ala Ile Ser 
1               5   


<210>  81
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5814

<400>  81

Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5814

<400>  82

Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5814

<400>  83

Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5814

<400>  84

Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5814

<400>  85

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  86
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5816

<400>  86

Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5816

<400>  87

Ser Tyr Thr Met Asn 
1               5   


<210>  88
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5816

<400>  88

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5816

<400>  89

Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5816

<400>  90

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe Leu Gln 
1               5                   10                  15      


Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  91
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5816

<400>  91

Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly Tyr Glu 
1               5                   10                  15      


Asp Tyr 
        


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5816

<400>  92

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  93
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5817

<400>  93

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Arg 
            20                  25                  30  


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5817

<400>  94

Ser Tyr Ala Ile Ser 
1               5   


<210>  95
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5817

<400>  95

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5817

<400>  96

Gly Ile Ile Pro Ile Phe Asp Thr Arg Asn Tyr Ala Gln Ile Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5817

<400>  97

Arg Val Thr Ile Thr Ala Asp Leu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5817

<400>  98

Gly Ser Asp Glu Gly Asp Trp Phe Asp Pro 
1               5                   10  


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5817

<400>  99

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  100
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW1 5818

<400>  100

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30  


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 5818

<400>  101

Asn Tyr Ala Ile Ser 
1               5   


<210>  102
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW2 5818

<400>  102

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 5818

<400>  103

Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  104
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW3 5818

<400>  104

Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 5818

<400>  105

Glu Tyr Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser 
1               5                   10          


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FW4 5818

<400>  106

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  107
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1337

<400>  107
gaggtgcagc tggtggagac tggggctgag gtgaagaagc cgggggcctc agtgaaggtc       60

tcctgcaagg cttctgacta catcttcacc aaatatgaca tcaactgggt gcgccaggcc      120

cctggacaag ggcttgaatg gatgggatgg atgagcgcta acactggaaa cacgggctat      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccataaa cacagcctac      240

atggagctga gcagcctgac atctggtgac acggccgttt atttctgtgc gaggagtagt      300

cttttcaaga cagagacggc gccctactat cacttcgctc tggacgtctg gggccaaggg      360

accacggtca ccgtctccag t                                                381


<210>  108
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3370

<400>  108
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggctgtgt attactgtgc aaaagatcgt      300

cattggcatt ggtggctgga cgcctttgat tattggggcc aaggtaccct ggtcaccgtc      360

tccagt                                                                 366


<210>  109
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3755

<400>  109
caggtgcagc tggtgcagtc tgggtctgag ttgaagaagc ctggggcctc agtgaagatt       60

tcctgcaagg cttctggata cgacttcact aactatgcta tgaattgggt gcgacaggcc      120

cctggacacg ggcttgagtg gatgggatgg atcaacgcca acactgggga cccaacgtat      180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagtttaaa ggctgaggac tctgccgtgt attactgtac gagagagcga      300

tttttggagt ggttacactt tgactactgg ggccagggaa ccctggtcac cgtctccagt      360


<210>  110
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF4280

<400>  110
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacaggct      120

cctggtaaag ggcttgaatg gatgggaggc tttgatcctg agtatggtaa aacattcttc      180

gcacagaact tccagggcag agtcaccatg accgaggaca catctgcaga cacagcctac      240

atggagctaa gcagcctgag atctgaggac acggccgtgt attactgtgc aacagagggg      300

tattatgaga ctactactta ttactacaac ctttttgact cctggggcca gggaaccctg      360

gtcaccgtct ccagt                                                       375


<210>  111
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF4289

<400>  111
caggtgcagc tggtgcaatc tgggtctgaa ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaaga cttctggata caccttcact gactatgcta tgacttgggt gcgacaggcc      120

cctggacaag ggcttgaatg gatgggatgg atcaccacca acactgggga cccaacgtat      180

gccccgggct tcacaggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggccgaggac actgccgtat attactgtgc gagagtgtat      300

cattggatac ggggatttga gttttggggc cagggaaccc tggtcaccgt ctccagt         357


<210>  112
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5790

<400>  112
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccttcagc agtagtagtt cctactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtttct attatagtgg gaacacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgaag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagacag      300

acgtatagca gcagctggga cggggtcctg tactactttg actactgggg ccagggaacc      360

ctggtcaccg tctccagt                                                    378


<210>  113
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5803

<400>  113
caggtgcagc tgcaggagtc ggggccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctaatgg ctccatcagt acttactact ggagctggat ccggcagccc      120

ccagggaagg ggctggagtg gattggatat gtctattaca ctgggcgcac caagtacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aacctgagtt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agggggtatt      300

gtagtagtcc cagctgcgcg ggactattac tactacatgg acgtctgggg caaagggacc      360

acggtcaccg tctccagt                                                    378


<210>  114
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5805

<400>  114
gaggtgcaac tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

gcctgtaagg gttctggatt cagttttacc agccactgga tcggctgggt gcgccagaag      120

cccgggagag gcctggagtg gatgggggtc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccgtc tcagccgaca agtccatcaa taccgcctac      240

ctgcagtgga acagcctgaa ggcctcggac accgccatat attactgtgc gagaccgaac      300

agtgggagtc cccggtactt cgagttctgg ggccgtggca ccctggtcac cgtctccagt      360


<210>  115
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5808

<400>  115
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtttct attatagtgg gaacacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagacag      300

gagtattact atggttcggg gagtccttcg tactactttg actactgggg ccagggaacc      360

ctggtcaccg tctccagt                                                    378


<210>  116
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5809

<400>  116
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggaga cagttttatc agccactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc gtctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcac caccgcctac      240

ttgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacacgag      300

tgggaactac ttggcccctt tgactactgg ggccagggaa ccctggtcac cgtctccagt      360


<210>  117
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5814

<400>  117
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg cacctccact aacgatgcta tcagttgggt gcgacagacc      120

cctggacaag ggcttgagtg gatgggaagt atcatcccta tccttgatac aacagaccac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgaa cacagcctac      240

atggagctga acagcctgag atctgatgac acggccgtgt attactgtgc gagagagcat      300

atagcagctc gtcaggacta ctttgactat tggggccagg gaaccctggt caccgtctcc      360

agt                                                                    363


<210>  118
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5816

<400>  118
gaggtgcagc tggtgcagtc tgggtctaaa ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatacta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacaccg acactgggga cccaacgtat      180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cctctgtcag cacggcattt      240

ctacagatca acagcctaaa ggctgaggac actgccgtat attactgtgc gagaggagat      300

tgtgatagta ccagctgcta tagatacagt tatggttacg aggactactg gggccaggga      360

accctggtca ccgtctccag t                                                381


<210>  119
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5817

<400>  119
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg tttctggagg caccttcagg agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttgatac aagaaactac      180

gcacagattc ttcagggcag agtcacgatt accgcggact tatccacgag cacagcctac      240

atggagctga acagtctgag atctgaggac acggccattt attactgtgc gagagggagc      300

gacgaggggg actggttcga cccctggggc caaggaaccc tggtcaccgt ctccagt         357


<210>  120
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5818

<400>  120
gaggtgcagc tggtgcagtc tgggactgag gtgaggaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc aactatgcta tcagctgggt gcgacaggcc      120

cctggacagg ggcttgagtg gatgggaagt atcatcccta tccttggaac aacagaccac      180

gcacagaagt tccaggacag agtcacgatt accgcggaca aatcctcgaa cacaacctac      240

atggagctga gcagcctgag atctgatgac acggccgtat attactgtgc gagagagtat      300

atagcagctc gtctggacta ctttgactct tggggccagg gaaccctggt caccgtctcc      360

agt                                                                    363


<210>  121
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  common light chain

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV1-39/jk1 variable region

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  123
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV1-39/jk1 variable region

<400>  123
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctacttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccaac gttcggccaa      300

gggaccaagg tggagatcaa a                                                321


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain constant region

<400>  124

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  125
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain constant region

<400>  125
gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg       60

gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt      120

ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca      180

gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga      240

aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga      300

gcttcaacag gggagagtgt                                                  320


<210>  126
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-region IGKV1-39A

<400>  126

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  127
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 LC

<400>  127

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  128
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 LC

<400>  128

Ala Ala Ser 
1           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 LC

<400>  129

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  130
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1

<400>  130
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtcgtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agtt            294


<210>  131
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1

<400>  131

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  132
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  132
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gccca                       45


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  133

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  134
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH2

<400>  134

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  135
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH2

<400>  135
gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc       60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      300

cccatcgaga aaaccatctc caaagccaaa                                       330


<210>  136
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3 L351K  and  T366K

<400>  136

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  137
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH3 L351K  and  T366K

<400>  137
gggcagcccc gagaaccaca ggtgtacacc aagcccccat cccgggagga gatgaccaag       60

aaccaggtca gcctgaagtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      120

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      180

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg      240

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      300

ctctccctgt ctccgggttg a                                                321


<210>  138
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3:  L351D  and  L368E

<400>  138

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Glu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  139
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH3:  L351D  and  L368E

<400>  139
gggcagcccc gagaaccaca ggtgtacacc gaccccccat cccgggagga gatgaccaag       60

aaccaggtca gcctgacctg cgaggtcaaa ggcttctatc ccagcgacat cgccgtggag      120

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      180

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg      240

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      300

ctctccctgt ctccgggttg a                                                321


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 LC

<400>  140

Gln Gln Ser Tyr Ser Thr Pro 
1               5           


<210>  141
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  141
gggccggggc gcgg                                                         14


<210>  142
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  142

Arg Ala Gly Ala Arg 
1               5   


