                         SEQUENCE LISTING

<110>  New York Genome Center, Inc.
       New York University
 
<120>  CHEMICALLY MODIFIED CRISPR-CAS13 GUIDE RNAS

<130>  NYG-LIPP130PCT

<140>  PCT/US2021/063314
<141>  2021-12-14

<150>  US 63/125,220
<151>  2020-12-14

<150>  US 63/148,966
<151>  2021-12-02

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucg              53


<210>  2
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sythetic construct

<400>  2
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugc              53


<210>  3
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucguuu           56


<210>  4
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugcuuu           56


<210>  5
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucguuu           56


<210>  6
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugcuuu           56


<210>  7
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucguuu           56


<210>  8
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugcuuu           56


<210>  9
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucgt             54


<210>  10
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugct             54


<210>  11
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucg              53


<210>  12
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugc              53


<210>  13
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucg              53


<210>  14
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugc              53


<210>  15
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15
aaccccuacc aacuggucgg gguuugaaac uccccgagga ggggcagcgc cgc              53


<210>  16
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16
aaccccuacc aacuggucgg gguuugaaac uccccgagga ggggcagcgc cgcuuu           56


<210>  17
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17
aaccccuacc aacuggucgg gguuugaaac uccccgagga ggggcagcgc cgcuuu           56


<210>  18
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18
aaccccuacc aacuggucgg gguuugaaac uccccgagga ggggcagcgc cgcuuu           56


<210>  19
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19
aaccccuacc aacuggucgg gguuugaaac uccccgagga ggggcagcgc cgct             54


<210>  20
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20
aaccccuacc aacuggucgg gguuugaaac uccccgagga ggggcagcgc cgc              53


<210>  21
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21
aaccccuacc aacuggucgg gguuugaaac uccccgagga ggggcagcgc cgc              53


<210>  22
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22
aaccccuacc aacuggucgg gguuugaaac cgagccaggc ugaaccgggu aua              53


<210>  23
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23
aaccccuacc aacuggucgg gguuugaaac cgagccaggc ugaaccgggu auauuu           56


<210>  24
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24
aaccccuacc aacuggucgg gguuugaaac cgagccaggc ugaaccgggu auauuu           56


<210>  25
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25
aaccccuacc aacuggucgg gguuugaaac cgagccaggc ugaaccgggu auauuu           56


<210>  26
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26
aaccccuacc aacuggucgg gguuugaaac cgagccaggc ugaaccgggu auat             54


<210>  27
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27
aaccccuacc aacuggucgg gguuugaaac cgagccaggc ugaaccgggu aua              53


<210>  28
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28
aaccccuacc aacuggucgg gguuugaaac cgagccaggc ugaaccgggu aua              53


<210>  29
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gau              53


<210>  30
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gauuuu           56


<210>  31
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gauuuu           56


<210>  32
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gauuuu           56


<210>  33
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gaut             54


<210>  34
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gau              53


<210>  35
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gau              53


<210>  36
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugc              53


<210>  37
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugc              53


<210>  38
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugc              53


<210>  39
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39
uuuaaccccu accaacuggu cgggguuuga aacgcggcgg ccgggaggcu ccaugc           56


<210>  40
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40
uuuaaccccu accaacuggu cgggguuuga aacgcggcgg ccgggaggcu ccaugcuuu        59


<210>  41
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41
aaccccuacc aacuggucgg gguuugaaac gcggcggccg ggaggcucca ugcuuu           56


<210>  42
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42
uuuaaccccu accaacuggu cgggguuuga aacgcggcgg ccgggaggcu ccaugc           56


<210>  43
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucg              53


<210>  44
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  44
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucg              53


<210>  45
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucg              53


<210>  46
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46
uuuaaccccu accaacuggu cgggguuuga aacagacaau ugugucgcug ccaucg           56


<210>  47
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47
uuuaaccccu accaacuggu cgggguuuga aacagacaau ugugucgcug ccaucguuu        59


<210>  48
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48
aaccccuacc aacuggucgg gguuugaaac agacaauugu gucgcugcca ucguuu           56


<210>  49
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49
uuuaaccccu accaacuggu cgggguuuga aacagacaau ugugucgcug ccaucg           56


<210>  50
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50
accccuacca acuggucggg guuugaaacu acuuaccuaa ugcgcgguag au               52


<210>  51
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gau              53


<210>  52
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gau              53


<210>  53
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53
uuuaaccccu accaacuggu cgggguuuga aacuacuuac cuaaugcgcg guagau           56


<210>  54
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gauuuu           56


<210>  55
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55
aaccccuacc aacuggucgg gguuugaaac uacuuaccua augcgcggua gauuuu           56


<210>  56
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  56
uuuaaccccu accaacuggu cgggguuuga aacuacuuac cuaaugcgcg guagau           56


<210>  57
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  57
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc caguuu           56


<210>  58
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  58
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uaguuu           56


<210>  59
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  59
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc cag              53


<210>  60
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  60
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc caguuu           56


<210>  61
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  61
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc caguuu           56


<210>  62
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  62
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc cagt             54


<210>  63
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  63
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc cag              53


<210>  64
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  64
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc cag              53


<210>  65
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  65
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uag              53


<210>  66
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  66
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uaguuu           56


<210>  67
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  67
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uaguuu           56


<210>  68
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  68
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uagt             54


<210>  69
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  69
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uag              53


<210>  70
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  70
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uag              53


<210>  71
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  71
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc cag              53


<210>  72
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  72
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc cag              53


<210>  73
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  73
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc cag              53


<210>  74
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  74
uuuaaccccu accaacuggu cgggguuuga aacgaucacu gaguccuucu cgccag           56


<210>  75
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  75
uuuaaccccu accaacuggu cgggguuuga aacgaucacu gaguccuucu cgccaguuu        59


<210>  76
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  76
aaccccuacc aacuggucgg gguuugaaac gaucacugag uccuucucgc caguuu           56


<210>  77
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  77
uuuaaccccu accaacuggu cgggguuuga aacgaucacu gaguccuucu cgccag           56


<210>  78
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  78
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uag              53


<210>  79
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  79
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uag              53


<210>  80
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  80
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uag              53


<210>  81
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  81
uuuaaccccu accaacuggu cgggguuuga aaccgaucac agcaauaguc ccauag           56


<210>  82
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  82
uuuaaccccu accaacuggu cgggguuuga aaccgaucac agcaauaguc ccauaguuu        59


<210>  83
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  83
aaccccuacc aacuggucgg gguuugaaac cgaucacagc aauaguccca uaguuu           56


<210>  84
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  84
uuuaaccccu accaacuggu cgggguuuga aaccgaucac agcaauaguc ccauag           56


<210>  85
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  85
aaccccuacc aacuggucgg gguuugaaac auaacaauca cagcaaugac ccat             54


<210>  86
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  86
aaccccuacc aacuggucgg gguuugaaac auaacaauca cagcaaugac cca              53


<210>  87
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  87
aaccccuacc aacuggucgg gguuugaaac ucacaaauag uauggguggc aagt             54


<210>  88
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  88
aaccccuacc aacuggucgg gguuugaaac ucacaaauag uauggguggc aag              53


<210>  89
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  89
aaccccuacc aacuggucgg gguuugaaac acuccacugg acagagcugc cugt             54


<210>  90
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  90
aaccccuacc aacuggucgg gguuugaaac acuccacugg acagagcugc cug              53


<210>  91
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  91
aaccccuacc aacuggucgg gguuugaaac gcaagcccau gguuacuagc guct             54


<210>  92
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  92
aaccccuacc aacuggucgg gguuugaaac gcaagcccau gguuacuagc guc              53


<210>  93
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  93
aaccccuacc aacuggucgg gguuugaaac uccaucauuc ugaacugcca cact             54


<210>  94
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  94
aaccccuacc aacuggucgg gguuugaaac uccaucauuc ugaacugcca cac              53


<210>  95
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  95
aaccccuacc aacuggucgg gguuugaaac caaguuucaa uaggagagcu gugt             54


<210>  96
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  96
aaccccuacc aacuggucgg gguuugaaac caaguuucaa uaggagagcu gug              53


<210>  97
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  97
aaccccuacc aacuggucgg gguuugaaac agaacagauc uacaagagau cga              53


<210>  98
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  98
aaccccuacc aacuggucgg gguuugaaac aaguugguug guuuguuacc ugg              53


<210>  99
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  99
aaccccuacc aacuggucgg gguuugaaac acaagagauc gaaaguuggu ugg              53


