                         SEQUENCE LISTING

<110>  BioArdis, LLC
 
<120>  GPC3 BINDING MOLECULES AND USES THEREOF

<130>  BWGB.010WO

<150>  US 63/127885
<151>  2020-12-18

<150>  US 63/262307
<151>  2021-10-08

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D04 HCDR1

<400>  1

Gly Phe Ile Phe Gly Phe Tyr Ala Met 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-E02 HCDR1

<400>  2

Gly Phe Ile Tyr Asp Ser Tyr Ile Met 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-A03 HCDR1

<400>  3

Gly Phe Ile Tyr Ser Ser Tyr Ala Met 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D01 HCDR1

<400>  4

Gly Phe Ile Tyr Ser Val Tyr Leu Met 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G01 HCDR1

<400>  5

Gly Arg Thr Phe Ser Tyr Asn Pro Met 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G02 HCDR1

<400>  6

Gly Ser Ile Phe Asp His Asn Val Met 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-H04 HCDR1

<400>  7

Gly Ser Ile Phe Arg Asp Tyr Ile Met 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-B03 HCDR1

<400>  8

Gly Ser Thr Leu Ser Asp Tyr Phe Met 
1               5                   


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A01 HCDR1

<400>  9

Gly Ser Ile Leu Ser Ile Tyr Val 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C01 HCDR1

<400>  10

Gly Phe Thr Phe Gly Phe Tyr Ser 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G01 HCDR1

<400>  11

Gly Phe Ile Phe Asn Phe Tyr Ser 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C02 HCDR1

<400>  12

Gly Phe Ile Ser Ser Asn Tyr Leu 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F02 HCDR1

<400>  13

Gly Phe Thr Leu Ser Pro Tyr Leu 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-B03 HCDR1

<400>  14

Gly Phe Ile Phe Arg Ser Tyr Ser 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G03 HCDR1

<400>  15

Gly Ser Thr Ser Asn Asn Asn Ile 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A04 HCDR1

<400>  16

Gly Phe Ile Phe Asp Asn Tyr Leu 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-D04 HCDR1

<400>  17

Gly Phe Ile Phe Arg Asn Tyr Ser 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F04 HCDR1

<400>  18

Gly Gly Ile Phe Asp Asp Tyr Ile 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G04 HCDR1

<400>  19

Gly Ser Thr Phe Ser Tyr Asn Pro 
1               5               


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D04 HCDR2

<400>  20

Ala Thr Ile Asn Pro Asn Asp Asp Ser Thr Tyr 
1               5                   10      


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-E02 HCDR2

<400>  21

Ala Ile Ser Arg Thr Gly Gly Ser Thr 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-A03 HCDR2

<400>  22

Ala Ile Ser Arg Thr Gly Gly Ser Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D01 HCDR2

<400>  23

Ala Ile Ser Arg Thr Gly Gly Ser Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G01 HCDR2

<400>  24

Ala Ile Ser Arg Thr Gly Gly Ser Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G02 HCDR2

<400>  25

Ala Ile Ser Arg Thr Gly Gly Ser Thr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-H04 HCDR2

<400>  26

Ser Ile Asn Ser Phe Ser Asp Ile Thr 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-B03 HCDR2

<400>  27

Ala Ile Ser Arg Thr Gly Gly Ser Thr 
1               5                   


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A01 HCDR2

<400>  28

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C01 HCDR2

<400>  29

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G01 HCDR2

<400>  30

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C02 HCDR2

<400>  31

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F02 HCDR2

<400>  32

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-B03 HCDR2

<400>  33

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G03 HCDR2

<400>  34

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A04 HCDR2

<400>  35

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-D04 HCDR2

<400>  36

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F04 HCDR2

<400>  37

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G04 HCDR2

<400>  38

Ile Ser Arg Thr Gly Gly Ser Thr 
1               5               


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D04 HCDR3

<400>  39

Ala Phe Trp Val Phe Asp Phe Asn Tyr Gly Tyr Trp 
1               5                   10          


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-E02 HCDR3

<400>  40

Val Ile Arg His Asn Arg Thr Met Arg Asn Pro Phe Asp Leu Asn Tyr 
1               5                   10                  15      


Trp 
    


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-A03 HCDR3

<400>  41

Val Ala Val Ile Asn Gln Trp Tyr Asn Tyr Trp 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D01 HCDR3

<400>  42

Ala Lys Thr Arg Tyr Arg Arg Phe Asn Tyr Trp 
1               5                   10      


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G01 HCDR3

<400>  43

Ala Thr Leu Pro Val Gln Val His Arg Ser His Asn Tyr Trp 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G02 HCDR3

<400>  44

Ala Asn Pro Ser Val Ser Gly Arg Ser Ser Phe Asn Tyr Trp 
1               5                   10                  


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-H04 HCDR3

<400>  45

Ala Trp His Ser Phe Ser Trp Arg Gly Gln Gln Arg Trp Tyr Asn Tyr 
1               5                   10                  15      


Trp 
    


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-B03 HCDR3

<400>  46

Ala Tyr Phe Arg Thr Gly Ser Tyr Ala Gly His Asp Tyr Trp 
1               5                   10                  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A01 HCDR3

<400>  47

Ala Asn Trp Tyr Phe Thr Glu Leu Ser Tyr 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C01 HCDR3

<400>  48

Ala Leu Asp Thr Arg Trp Gly Leu Asn Tyr 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G01 HCDR3

<400>  49

Val Leu Asp Gln Val Tyr Gly Leu Ser Tyr 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C02 HCDR3

<400>  50

Ala Gly Lys Pro Tyr Glu Thr His Gly Tyr 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F02 HCDR3

<400>  51

Ala Lys Arg Met Gly Glu Ile Phe Asn Tyr 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-B03 HCDR3

<400>  52

Val Leu Asp Ser Thr Tyr Gly Phe Gly Tyr 
1               5                   10  


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G03 HCDR3

<400>  53

Val Gly Gly Gly Arg Gly Arg Leu Asn Ser His Gly Tyr 
1               5                   10              


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A04 HCDR3

<400>  54

Ala Lys Phe Pro Trp Lys Val Phe Asp Tyr 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-D04 HCDR3

<400>  55

Val Ala Val Thr Arg Glu Trp Tyr Asn Tyr 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F04 HCDR3

<400>  56

Ala Lys Val Pro Tyr His Pro Phe Asn Tyr 
1               5                   10  


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G04 HCDR3

<400>  57

Val Arg Lys Phe His Met Tyr Asn Pro Met Met Met Phe Leu Asn Tyr 
1               5                   10                  15      


<210>  58
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D04 VH

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Phe Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Thr Ile Asn Pro Asn Asp Asp Ser Thr Tyr Tyr Tyr Pro Asp 
    50                  55                  60                  


Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Phe Trp Val Phe Asp Phe Asn Tyr Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-E02 VH

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Tyr Asp Ser Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ile Arg His Asn Arg Thr Met Arg Asn Pro Phe Asp Leu Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  60
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-A03 VH

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Tyr Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ala Val Ile Asn Gln Trp Tyr Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  61
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-D01 VH

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Tyr Ser Val Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Thr Arg Tyr Arg Arg Phe Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  62
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G01 VH

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Tyr Asn 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Leu Pro Val Gln Val His Arg Ser His Asn Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  63
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-G02 VH

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asp His Asn 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Pro Ser Val Ser Gly Arg Ser Ser Phe Asn Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  64
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-H04 VH

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Asp Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Phe Ser Asp Ile Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Trp His Ser Phe Ser Trp Arg Gly Gln Gln Arg Trp Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G-B03 VH

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Ser Asp Tyr 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Phe Arg Thr Gly Ser Tyr Ala Gly His Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  66
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A01 VH

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Ser Ile Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Trp Tyr Phe Thr Glu Leu Ser Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  67
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C01 VH

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Phe Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Leu Asp Thr Arg Trp Gly Leu Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  68
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G01 VH

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Phe Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Leu Asp Gln Val Tyr Gly Leu Ser Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Ser Asp Tyr Lys Asp Asp 
        115                 120                 125     


<210>  69
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-C02 VH

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Ser Ser Asn Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Lys Pro Tyr Glu Thr His Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  70
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F02 VH

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Pro Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Arg Met Gly Glu Ile Phe Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  71
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-B03 VH

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Leu Asp Ser Thr Tyr Gly Phe Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  72
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G03 VH

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ser Asn Asn Asn 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Gly Gly Arg Gly Arg Leu Asn Ser His Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  73
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-A04 VH

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asn Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Phe Pro Trp Lys Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  74
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-D04 VH

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ala Val Thr Arg Glu Trp Tyr Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-F04 VH

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ile Phe Asp Asp Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Val Pro Tyr His Pro Phe Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  76
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-G04 VH

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Tyr Asn 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Lys Phe His Met Tyr Asn Pro Met Met Met Phe Leu Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


